A vaccine adjuvant filtration device

Abstract

The present application relates to a kind of vaccine adjuvant filtering device, including the support for supporting equipment, the top of support is equipped with filter, the inside of filter is equipped with filtering mechanism.The present application is used, the adjuvant of external grinding and preparation is input from inlet pipe, and after filtering, it is output to qualified liquid collection end from outlet pipe.In use for a period of time, the pressure of outlet pipe end decreases, prove that the filtering capacity of filter block decreases, system automatically or manually starts motor, drives rotating ring structure to rotate fixed angle, and filter block is replaced.After replacement is completed, flushing pipe is filled with cleaning fluid, and the material in filter block is washed out in reverse, and is directly output to external grinding and stirring equipment through recovery pipe to be reprocessed, thereby effectively solve the problem that existing vaccine adjuvant is filtered, filter block replacement needs to be disassembled and is easily caused by adjuvant pollution, and have the effect of recycling and reprocessing, can save production cost.

Description

Technical Field

[0001] This invention relates to the field of filtration technology in vaccine production, specifically to a vaccine adjuvant filtration device. Background Technology

[0002] Vaccine adjuvants are substances that can non-specifically alter or enhance the body's specific immune response to antigens, playing a supportive role. Adjuvants can induce a long-term, highly effective specific immune response, improving the body's protective ability, while simultaneously reducing the amount of immune substances required and lowering vaccine production costs.

[0003] Currently, there is no unified international standard for the classification of adjuvants. Based on different chemical compositions, they can be divided into several categories, such as aluminum salt adjuvants, protein adjuvants, nucleic acid adjuvants, lipid adjuvants, and mixed adjuvants. In the vaccine production process, both chemical and biological adjuvants need to be filtered to control the uniformity of the particles inside the adjuvant, ensure that the vaccine matrix can be evenly attached, and ensure the best immune effect.

[0004] Vaccine adjuvants are inactive components of vaccines, primarily used as auxiliary ingredients to enhance the vaccine's immune effect. To ensure the quality and purity of vaccine adjuvants, filtration technology is typically employed during the production process.

[0005] Filtration removes microorganisms, impurities, and other contaminants from adjuvants. Vaccine adjuvants are typically in solution form, and filtration technology effectively removes insoluble or particulate matter. During vaccine production, various contaminants can affect the adjuvant, such as air, water, and equipment. Using filters effectively removes these contaminants, reducing the risk of contamination. The selection and optimization of filtration technology can significantly improve the quality of vaccine adjuvants, enhancing vaccine safety and efficacy.

[0006] Existing technologies, such as patent application number CN202121963385.3, employ a diversion filtration method to filter the vaccine adjuvant carrier. This filtration method has the disadvantage of requiring the filter to be disassembled for cleaning. During the disassembly and cleaning process, impurities, viruses, or bacteria in the air can easily be adsorbed inside the filter, causing contamination of the adjuvant during re-filtration. In view of the above problems, a vaccine adjuvant filtration device is proposed. Summary of the Invention

[0007] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a vaccine adjuvant filtration device, which effectively solves the problem that the existing vaccine adjuvants are easily contaminated when the filter screen needs to be disassembled during filtration and replacement. It also has the function of recycling and reprocessing, which can save production costs.

[0008] To achieve the above objectives, the main technical solutions adopted by the present invention include:

[0009] A vaccine adjuvant filtration device includes a support bracket for supporting the device, a filter mounted on the top of the support bracket, and a filtration mechanism mounted inside the filter. The filter includes a housing, and a fixing shell is welded to the outer side of the housing. The filtration mechanism includes a rotating ring structure, with mounting holes evenly arranged inside the rotating ring structure. Cylindrical filter blocks are mounted inside the mounting holes. An outlet pipe and a flushing pipe are staggered and fitted onto the front end of the outer surface of the mounting hole, with the same number of outlet pipes and flushing pipes. An inlet pipe is fitted onto the rear end of the outer surface of the mounting hole corresponding to the outlet pipe.

[0010] Alternatively, the bracket includes a base, the upper surface of which is fitted with a support rod, the top end of which is fitted onto the lower surface of the filter.

[0011] Optionally, the outer surface of the housing is provided with a second mounting hole, the interior of which is sealed and fitted onto the outer surface of the flushing pipe, the outlet pipe and the inlet pipe respectively.

[0012] Optionally, the flushing pipe, the outlet pipe, and the inlet pipe are all equipped with check valves. The internal liquid transmission direction of the flushing pipe is opposite to that of the outlet pipe, and the liquid transmission direction of the outlet pipe is the same as that of the inlet pipe.

[0013] Further optionally, the number of mounting holes is preferably 8, and the preferred number of filter blocks used is 8.

[0014] Optionally, the outer surface of the rotating ring structure is provided with a gear groove, and a gear meshes with the outer surface of the gear groove. A motor is mounted at the center of the gear, and the output end of the motor passes through the fixed shell and is mounted at the center of the gear.

[0015] Further optionally, the outer shell and the fixed shell are preferably made of transparent pressure-resistant materials, such as tempered glass or transparent polyethylene plastic.

[0016] Optionally, the inner ends of the flushing pipe, the outlet pipe, and the inlet pipe each have an outwardly extending annular plate, and a sealing ring is fitted on the inner side of the annular plate. The outer ends of the flushing pipe, the outlet pipe, and the inlet pipe each have a threaded structure.

[0017] Optionally, a pressure sensor or pressure gauge may be fitted in the middle of the external connecting pipe of the liquid outlet pipe.

[0018] Alternatively, a recycling pipe may be welded to the bottom of the outer casing.

[0019] The vaccine adjuvant filtration device of the present invention has the following beneficial effects:

[0020] (1) The present invention provides a filtration device with a ring-shaped rotating filter block. When in use, the externally ground and prepared adjuvant is input from the inlet pipe, and after filtration, it is output from the outlet pipe to the qualified liquid collection end. After a period of use, the pressure at one end of the outlet pipe decreases, indicating that the filtration capacity of the filter block has decreased. The system automatically or manually starts the motor to drive the rotating ring structure to rotate at a fixed angle to replace the filter block. After replacement, the flushing pipe is filled with cleaning liquid to flush out the material inside the filter block in reverse. The material is directly output through the recycling pipe to the external grinding and stirring equipment for reprocessing. The cleaned filter block is ready for the next cycle of use. This effectively solves the problem that the existing vaccine adjuvants require disassembly when the filter block is replaced, which can easily cause the adjuvant to be contaminated. It also has the function of recycling and reprocessing, which can save production costs.

[0021] (2) By setting the fixed shell to a transparent pressure-resistant material, the present invention can also directly observe the filtration status of the filter device, check whether there is blockage or contamination, and can better filter the vaccine adjuvant when used with the filter device, while also facilitating the adjustment of the filter device. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the structure of an embodiment of the present invention;

[0023] Figure 2 This is a schematic diagram of the cross-sectional structure of the filter according to an embodiment of the present invention;

[0024] Figure 3 This is an assembly diagram of the filtration mechanism according to an embodiment of the present invention;

[0025] Figure 4 This is a schematic diagram of the filter mechanism assembly according to an embodiment of the present invention;

[0026] Figure 5 This is a cross-sectional assembly diagram of the filter mechanism according to an embodiment of the present invention.

[0027] [Explanation of Labels in the Attached Image]

[0028] 1. Bracket; 11. Base; 12. Support rod; 2. Filter; 21. Housing; 22. Fixing housing; 23. Second mounting hole; 24. Recovery pipe; 3. Filtering mechanism; 31. Rotary ring structure; 32. Mounting hole; 33. Filter block; 34. Flushing pipe; 35. Liquid outlet pipe; 36. Liquid inlet pipe; 37. Gear; 38. Motor. Detailed Implementation

[0029] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0030] It should be noted that the following detailed descriptions are illustrative and intended to provide further explanation of this application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains.

[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] Please see Figures 1-5 This invention provides a vaccine adjuvant filtration device, comprising a support 1 for supporting the device, a filter 2 mounted on the top of the support 1, and a filtration mechanism 3 mounted inside the filter 2; the filter 2 includes a housing 21, and a fixing shell 22 welded to the outer side of the housing 21. The filtration mechanism 3 includes a rotating ring structure 31, with mounting holes 32 uniformly arranged inside the rotating ring structure 31, and filter blocks 33 mounted inside the mounting holes 32. An outlet pipe 35 and a flushing pipe 34 are alternately fitted to the front end of the outer surface of the mounting holes 32, with the same number of outlet pipes 35 and flushing pipes 34. An inlet pipe 36 is attached to the rear end of the outer surface of the mounting holes 32 corresponding to the outlet pipes 35.

[0033] This invention provides a filtration device with a rotating annular filter block 33. During use, externally ground and prepared adjuvant is input through the inlet pipe 36, filtered, and output through the outlet pipe 35 to a qualified liquid collection end. After a period of use, the pressure at one end of the outlet pipe 36 decreases, indicating a decline in the filtration capacity of the filter block 33. The system automatically or manually starts the motor 38, driving the rotating ring structure 31 to rotate at a fixed angle to replace the filter block 33. After replacement, the flushing pipe 34 is filled with cleaning fluid, flushing out the material inside the filter block 33 in reverse. This material is then directly output through the recovery pipe 24 to external grinding and stirring equipment for reprocessing. This effectively solves the problem of adjuvant contamination caused by the disassembly of filter blocks during existing vaccine adjuvant filtration processes, and also allows for recycling and reprocessing, saving production costs.

[0034] Furthermore, the bracket 1 includes a base 11, with a support rod 12 mounted on the upper surface of the base 11, and the top end of the support rod 12 mounted on the lower surface of the filter 2. The size of the bracket 1 needs to be set according to the installation position of the filter 2, and it has the effect of saving space with its small size, making it very convenient to use.

[0035] Furthermore, the outer surface of the outer casing 21 is uniformly provided with second mounting holes 23. The interior of the second mounting holes 23 is respectively sealed and fitted onto the outer surfaces of the flushing pipe 34, the outlet pipe 35, and the inlet pipe 36.

[0036] Furthermore, check valves are installed in the flushing pipe 34, the outlet pipe 35, and the inlet pipe 36. The internal liquid transmission direction of the flushing pipe 34 is opposite to that of the outlet pipe 35, while the liquid transmission direction of the outlet pipe 35 is the same as that of the inlet pipe 36. By using the flushing pipe 34 with its opposite transmission direction, when flushing liquid is injected, materials with unqualified particle sizes that are blocked inside the filter block 33 can be flushed out from the other end, resulting in good flushing effect and fast flushing speed.

[0037] In this embodiment, the number of mounting holes 32 is preferably 8, and the preferred number of filter blocks 33 is 8. Four sets of inlet pipes 36 and outlet pipes 35 are symmetrically arranged. This way, the normal filtration of the equipment will not be affected when the cleaning work is carried out after conversion. The number of mounting holes 32 is the same as the number of filter blocks 33 used, and the number of filter blocks 33 used is twice that of outlet pipes 35, ensuring that the filtration and rinsing do not conflict with each other.

[0038] Furthermore, a gear groove is formed on the outer surface of the rotating ring structure 31, and a gear 37 meshes with the outer surface of the gear groove. A motor 38 is mounted at the center of the gear 37, and the output end of the motor 38 passes through the fixed shell 22 and is mounted at the center of the gear 37. A stepper motor or servo motor with a worm gear reducer with a self-locking function is mounted at the front end of the motor 38, which can lock the gear 37 after it has finished rotating, ensuring that the rotating ring structure 31 will not rotate passively, thus ensuring normal filtration and rinsing effects.

[0039] Furthermore, the preferred materials for the outer casing 21 and the fixed casing 22 are transparent and pressure-resistant materials, such as tempered glass or transparent polyethylene plastic, to facilitate observation of the internal operation of the equipment. As long as the filtration pressure can be maintained, the outer casing 21 is preferably made of a transparent material.

[0040] Furthermore, the inner ends of the flushing pipe 34, the outlet pipe 35, and the inlet pipe 36 all have outwardly extending annular plates. A sealing ring is fitted inside the annular plate, and threaded structures are provided at the outer ends of the flushing pipe 34, the outlet pipe 35, and the inlet pipe 36. The annular plates ensure a tight seal at the contact points between the flushing pipe 34, the outlet pipe 35, and the inlet pipe 36 and the rotating ring structure 31, preventing leakage.

[0041] Furthermore, a pressure sensor or pressure gauge is installed in the middle of the external connecting pipe of the liquid outlet pipe 35. The pressure sensor, together with the background control computer, can realize the automatic control of the motor 38, thereby achieving an automated flushing effect. Alternatively, the pressure gauge alarm can be used to achieve the effect of manual start control.

[0042] Furthermore, a recycling tube 24 is welded to the bottom end of the outer casing 21.

[0043] Based on the aforementioned technical features, the working principle of the vaccine adjuvant filtration device provided in this application in practical application scenarios is as follows:

[0044] After a period of use, the pressure at one end of the outlet pipe 36 decreases, indicating that the filtration capacity of the filter block 33 has declined. The system automatically or manually starts the motor 38, driving the rotating ring structure 31 to rotate at a fixed angle to replace the filter block 33. After replacement, the flushing pipe 34 is filled with cleaning fluid, which flushes out the material inside the filter block 33 in reverse, and outputs it directly to the external grinding and mixing equipment for reprocessing through the recovery pipe 24.

[0045] Unless otherwise specifically stated, the relative arrangement of components illustrated in these embodiments does not limit the scope of the invention. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following figures denote similar items; therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0046] In the description of this invention, it should be understood that the orientation or positional relationship indicated by directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" is generally based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing this invention and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this invention; the directional terms "inner" and "outer" refer to the inner and outer contours relative to the outline of each component itself.

[0047] For ease of description, spatial relative terms such as "above," "on top of," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation beyond the orientation of the device as described in the figures. For example, if the device in the figures were inverted, a device described as "above" or "on top of" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0048] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0049] It should be noted that the terms "first," "second," etc., used in the specification, claims, and accompanying drawings of this application are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this application described herein can be implemented in sequences other than those illustrated or described herein.

[0050] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A vaccine adjuvant filtration device, characterized in that, Includes a support bracket (1) for supporting the equipment, the top of which is fitted with a filter (2), and the filter (2) is fitted with a filtration mechanism (3) inside; The filter (2) includes a housing (21), and a fixed shell (22) is welded to the outside of the housing (21); The filtration mechanism (3) includes a rotating ring structure (31). The rotating ring structure (31) has uniformly arranged mounting holes (32) inside. The mounting holes (32) are fitted with cylindrical filter blocks (33). The front end of the outer surface of the mounting holes (32) is respectively staggered with an outlet pipe (35) and a flushing pipe (34). The number of outlet pipes (35) and flushing pipes (34) is the same. The rear end of the outlet pipe (35) is attached to the outer surface of the mounting hole (32) of the corresponding outlet pipe (35). The outer surface of the outer shell (21) is uniformly provided with second mounting holes (23), and the interior of the second mounting holes (23) is respectively sealed and assembled on the outer surface of the flushing pipe (34), the liquid outlet pipe (35) and the liquid inlet pipe (36); The flushing pipe (34), the outlet pipe (35) and the inlet pipe (36) are all equipped with check valves. The internal liquid transmission direction of the flushing pipe (34) is opposite to that of the outlet pipe (35), and the liquid transmission direction of the outlet pipe (35) is the same as that of the inlet pipe (36). The inner ends of the flushing pipe (34), the outlet pipe (35) and the inlet pipe (36) are all provided with outwardly extending annular plates, and sealing rings are installed on the inner side of the annular plates. The outer ends of the flushing pipe (34), the outlet pipe (35) and the inlet pipe (36) are all provided with threaded structures. The number of mounting holes (32) is 8, and the number of filter blocks (33) used is 8; The outer surface of the rotating ring structure (31) is provided with a gear groove, and a gear (37) meshes with the outer surface of the gear groove. A motor (38) is assembled at the center of the gear (37), and the output end of the motor (38) passes through the fixed shell (22) and is assembled at the center of the gear (37).

2. The vaccine adjuvant filtration device according to claim 1, characterized in that: The bracket (1) includes a base (11), the upper surface of which is fitted with a support rod (12), the top end of which is fitted to the lower surface of the filter (2).

3. The vaccine adjuvant filtration device according to claim 1, characterized in that: The preferred materials for the outer shell (21) and the fixed shell (22) are transparent and pressure-resistant materials.

4. The vaccine adjuvant filtration device according to claim 1, characterized in that: A pressure sensor or pressure gauge is installed in the middle of the external connecting pipe of the outlet pipe (35).

5. The vaccine adjuvant filtration device according to claim 1, characterized in that: A recycling tube (24) is welded to the bottom end of the outer shell (21).

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