A liquid path distribution system, a liquid supply method and a fully automatic biochemical analyzer

Abstract

The present invention discloses a liquid path distribution system, a liquid supply method and a fully automatic biochemical analyzer. The liquid path distribution system includes a deionized water storage device, an alkaline cleaning liquid storage device, a cleaning needle assembly and a distribution liquid path. The cleaning needle assembly includes an alkaline cleaning needle and a conventional cleaning needle. The distribution liquid path includes an alkaline cleaning liquid supply liquid path, a deionized water supply liquid path and a branch. One end of the alkaline cleaning liquid supply liquid path is connected to the alkaline cleaning needle, and the other end is connected to the alkaline cleaning liquid storage device. One end of the deionized water supply liquid path is connected to the conventional cleaning needle, and the other end is connected to the deionized water storage device. The branch is connected between the alkaline cleaning liquid supply liquid path and the deionized water supply liquid path. The present invention simplifies the liquid path structure, reduces the control difficulty of the electrical system for the liquid path system, improves the stability of the liquid path system, and reduces the cost.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnosis, and particularly to a liquid path distribution system, a liquid supply method and a fully automatic biochemical analyzer. Background Art

[0002] In clinical detection, biochemical analysis is a very important test, and biochemical analysis tests are usually completed by a biochemical analyzer. A biochemical analyzer is an instrument that uses the principle of photoelectric colorimetry to measure a specific chemical component in body fluid. With the development of science and technology, fully automatic biochemical analyzers are widely used in the detection of routine biochemical indicators such as liver function and kidney function. In terms of cleaning, in addition to normally completing the work of adding deionized water to multiple cuvettes, a small amount of alkaline cleaning solution needs to be injected into the cuvettes through one of the cleaning needles. The common method on the market to complete the injection of alkaline cleaning solution is to add a pump and a solenoid valve to the pipeline through which the alkaline cleaning solution flows, so that it can separately supply the alkaline cleaning solution for a single cleaning needle. This method not only increases the requirements for liquid path electrical control, but also greatly increases the complexity of the liquid path system, reduces the fault tolerance rate, and increases the cost. Summary of the Invention

[0003] In order to solve the above problems, the present invention discloses a liquid path distribution system, a liquid supply method and a fully automatic biochemical analyzer to solve the problem of complex liquid path system in the prior art.

[0004] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0005] A liquid path distribution system includes a deionized water storage device, an alkaline cleaning solution storage device, a cleaning needle assembly, and a distribution liquid path; the cleaning needle assembly includes an alkaline solution cleaning needle and a conventional cleaning needle; the distribution liquid path includes an alkaline cleaning solution supply liquid path, a deionized water supply liquid path, and a branch; one end of the alkaline cleaning solution supply liquid path is connected to the alkaline solution cleaning needle, and the other end is connected to the alkaline cleaning solution storage device; one end of the deionized water supply liquid path is connected to the conventional cleaning needle, and the other end is connected to the deionized water storage device; the branch is connected between the alkaline cleaning solution supply liquid path and the deionized water supply liquid path.

[0006] Further, the branch includes a first branch and a second branch; one end of the first branch is connected to the alkaline cleaning solution supply liquid path, and the other end is connected to the deionized water supply liquid path; one end of the second branch is connected to the first branch, and the other end is connected to the deionized water supply liquid path.

[0007] Further, along the flow direction of deionized water, a two-way valve Sv11 and a pump P0 are sequentially arranged on the deionized water supply line; along the flow direction of the alkaline cleaning solution, a two-way valve Sv10 and a two-way valve Sv3 are sequentially arranged on the alkaline cleaning solution supply line; a three-way valve Sv9 is arranged on the first branch; one end of the first branch is connected to the deionized water supply line between the pump P0 and the two-way valve Sv11, and the other end is connected to the alkaline cleaning solution supply line between the two-way valve Sv3 and the two-way valve Sv10; the deionized water supply line on the side of the pump P0 away from the two-way valve Sv11 is connected to the three-way valve Sv9 through a second branch.

[0008] Further, two conventional cleaning needles are provided, and are respectively connected to the deionized water supply line through a first elbow Q3 and a second elbow Q5; a two-way valve Sv5 is arranged on the pipeline of the first elbow Q3, and a two-way valve SV4 is arranged on the pipeline of the second elbow Q5; the alkaline solution cleaning needle is connected to the two-way valve Sv3 through a third elbow Q7.

[0009] Further, it further includes a probe assembly and a probe cleaning pool; the probe assembly is connected to the deionized water storage device through a probe liquid line; the probe cleaning pool is connected to the deionized water supply line through the deionized water supply line.

[0010] A liquid supply method for a liquid line, the liquid line includes an alkaline cleaning solution supply line, a deionized water supply line and a branch; the branch is connected between the alkaline cleaning solution supply line and the deionized water supply line; the method includes the following steps:

[0011] Extract the alkaline cleaning solution to flow from the alkaline cleaning solution supply line to the branch.

[0012] Extract deionized water to flow through the deionized water supply line to the branch, and the deionized water carries the alkaline cleaning solution on the branch and flows through the alkaline cleaning solution supply line to the alkaline solution cleaning needle.

[0013] Further, the branch includes a first branch and a second branch; one end of the first branch is connected to the alkaline cleaning solution supply line, and the other end is connected to the deionized water supply line; one end of the second branch is connected to the first branch, and the other end is connected to the deionized water supply line;

[0014] When extracting the alkaline cleaning solution, the alkaline cleaning solution flows from the alkaline cleaning solution supply line to the first branch.

[0015] When extracting deionized water, the deionized water flows through the deionized water supply line and the second branch to the first branch, and the deionized water carries the alkaline cleaning solution on the first branch and flows through the alkaline cleaning solution supply line to the alkaline solution cleaning needle.

[0016] Further, a pump P0 is provided between the connection nodes of the first branch, the second branch and the deionized water supply liquid path; a three-way valve Sv9 is provided at the connection node of the first branch and the second branch;

[0017] When extracting the alkaline cleaning liquid, the alkaline cleaning liquid is extracted by the pump P0 and flows from the alkaline cleaning liquid supply liquid path to the three-way valve Sv9;

[0018] When extracting deionized water, the deionized water is extracted by the pump P0 and flows through the deionized water supply liquid path, the second branch, and the three-way valve Sv9 to the first branch. The deionized water carries the alkaline cleaning liquid on the first branch and flows through the alkaline cleaning liquid supply liquid path to the alkaline solution cleaning needle.

[0019] A fully automatic biochemical analyzer includes the liquid path distribution system described above.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] By connecting a branch between the alkaline cleaning liquid supply liquid path and the deionized water supply liquid path, the present invention enables the alkaline cleaning liquid and deionized water to be sequentially supplied to the alkaline solution cleaning needle through the branch and the alkaline cleaning liquid supply liquid path; the supply of the alkaline cleaning liquid and the deionized water for the alkaline solution cleaning needle share the same pipeline, which not only ensures the supply of the alkaline cleaning liquid but also simplifies the liquid path system and reduces the cost. Description of the Drawings

[0022] Figure 1 It is a schematic diagram of the liquid path distribution system of the present invention.

[0023] Reference numerals: 1 - deionized water storage device; 2 - alkaline cleaning liquid storage device; 3 - probe assembly; 4 - cleaning needle assembly; 5 - probe cleaning pool; 6 - alkaline cleaning liquid supply liquid path; 7 - deionized water supply liquid path; 8 - first branch; 9 - second branch; 10 - high-concentration waste liquid recovery tank; 11 - low-concentration waste liquid recovery tank. Specific Embodiments

[0024] To make the purpose, technical solutions and advantages of the present invention clearer and more definite, the present invention will be further described in detail below with reference to the drawings and by way of examples.

[0025] Such as Figure 1As shown in the figure, a liquid path distribution system includes a deionized water storage device 1, an alkaline cleaning solution storage device 2, a probe assembly 3, a cleaning needle assembly 4, a probe cleaning pool 5, and a distribution liquid path. The probe assembly 3 is connected to the deionized water storage device 1 through a probe liquid path, and a pump P3, double-pass valves Sv1, and Sv1 are provided on the probe liquid path. The cleaning needle assembly 4 includes an alkaline cleaning needle and a conventional cleaning needle. When cleaning the colorimetric cup, the alkaline cleaning needle is used to sequentially add a small amount of alkaline cleaning solution and deionized water to the colorimetric cup for cleaning. When cleaning the colorimetric cup, the conventional cleaning needle only provides deionized water for cleaning. The distribution liquid path includes an alkaline cleaning solution supply liquid path 6, a deionized water supply liquid path 7, and a branch. One end of the alkaline cleaning solution supply liquid path 6 is connected to the alkaline cleaning needle, and the other end is connected to the alkaline cleaning solution storage device 2. One end of the deionized water supply liquid path 7 is connected to the conventional cleaning needle and the probe cleaning pool 5 respectively, and the other end is connected to the deionized water storage device 1. The branch is connected between the alkaline cleaning solution supply liquid path 6 and the deionized water supply liquid path 7. The distribution liquid path is used to distribute and supply deionized water to the cleaning needle assembly 4 and the probe cleaning pool 5 or supply alkaline cleaning solution to the cleaning needle assembly 4.

[0026] The probe assembly 3 is used to aspirate a sample or a reagent and add the sample or the reagent into a colorimetric cup for a biochemical reaction. After each aspiration and ejection of the sample or the reagent by the probe assembly 3, deionized water is inhaled through the probe liquid path to clean its interior, and at the same time, its exterior is cleaned through the probe cleaning pool 5.

[0027] The branch includes a first branch 8 and a second branch 9. One end of the first branch 8 is connected to the alkaline cleaning solution supply liquid path 6, and the other end is connected to the deionized water supply liquid path 7. One end of the second branch is connected to the first branch 8, and the other end is connected to the deionized water supply liquid path 7.

[0028] Along the flow direction of the deionized water, a double-pass valve Sv11 and a pump P0 are sequentially provided on the deionized water supply liquid path 7. Along the flow direction of the alkaline cleaning solution, a double-pass valve Sv10 and a double-pass valve Sv3 are sequentially provided on the alkaline cleaning solution supply liquid path 6. A three-way valve Sv9 is provided on the first branch 8. One end of the first branch 8 is connected to the deionized water supply liquid path 7 between the pump P0 and the double-pass valve Sv11, and the other end is connected to the alkaline cleaning solution supply liquid path 6 between the double-pass valve Sv3 and the double-pass valve Sv10. The deionized water supply liquid path 7 on the side of the pump P0 away from the double-pass valve Sv11 is connected to the three-way valve Sv9 through the second branch 9. Other double-pass valves are also provided on the deionized water supply liquid path 7 between the conventional cleaning needle and the probe cleaning pool 5. The three-way valve Sv9 is a normally closed three-way solenoid valve.

[0029] Specifically, the cleaning needle assembly 4 in this embodiment includes one lye cleaning needle, two conventional cleaning needles, and two drying cleaning needles; the two conventional cleaning needles are respectively connected to the deionized water supply line 7 through the first elbow Q3 and the second elbow Q5; the lye cleaning needle is connected to the alkaline cleaning solution supply line 6 through the third elbow Q7. The two drying cleaning needles, the two conventional cleaning needles, and the lye cleaning needle are respectively connected to the high-concentration waste liquid recovery tank 10 through the first waste liquid elbow Q1, the second waste liquid elbow Q2, the third waste liquid elbow Q4, and the fourth waste liquid elbow Q6.

[0030] A two-way valve Sv5 is provided on the pipeline of the first elbow Q3, a two-way valve Sv4 is provided on the pipeline of the second elbow Q5, and a two-way valve Sv3 of the third elbow Q7 is connected to the alkaline cleaning solution supply line 7.

[0031] Through the pipeline systems corresponding to the two-way valves Sv3, Sv4, and Sv5, deionized water can be independently extracted and injected into the corresponding colorimetric cups, or they can work simultaneously. Among them, the injection of alkaline cleaning solution can also be controlled in the pipeline systems corresponding to the two-way valves Sv3 and Sv10.

[0032] In this embodiment, the probe assembly 3 is set to two, namely probe R1 and probe R2. The probe cleaning pools 5 corresponding to probe R1 and probe R2 are the first probe cleaning pool and the second probe cleaning pool respectively; both the first probe cleaning pool and the second probe cleaning pool are connected to the deionized water supply line 7 through corresponding pipelines; a two-way valve Sv6 is provided on the corresponding pipeline between the first probe cleaning pool and the pump P0, and a two-way valve Sv7 is provided on the corresponding pipeline between the second probe cleaning pool and the pump P0; at the same time, the first probe cleaning pool and the second probe cleaning pool are also connected to the low-concentration waste liquid recovery tank 11.

[0033] When extracting the alkaline cleaning solution, the two-way valves Sv3 and Sv11 are in the normally closed state, and the three-way valve Sv9 and the two-way valve Sv10 are in the working state through electrical control. One of the two-way valves Sv4, Sv5, Sv6, and Sv7 is in the working state, and the others are in the closed state.

[0034] For example, the two-way valves Sv3, Sv4, Sv5, Sv7, and Sv11 are in the normally closed state, and the two-way valves Sv6, the three-way valve Sv9, and the two-way valve Sv10 are in the working state through electrical control. At this time, the second branch 9 where the three-way valve Sv9 is located is in the closed state, and the first branch 8 where the three-way valve Sv9 is located is in the open state. When the pump P0 is turned on, the alkaline cleaning liquid can flow along the two-way valve Sv10, the three-way valve Sv9, the pump P0, and the two-way valve Sv6 towards the probe R1 cleaning tank under the action of the pump P0. Before the alkaline cleaning liquid enters the three-way valve Sv9, the pump P0 is turned off, so that a small amount of alkaline cleaning liquid remains in the pipeline between the three-way valve Sv9 and the two-way valve Sv10, and the content of the small amount of alkaline cleaning liquid is controlled by the working suction time of the pump P0.

[0035] When transporting the alkaline cleaning liquid, the three-way valve Sv9 and the two-way valve Sv10 are in the normally closed state, and the two-way valves Sv3, Sv4, Sv5, Sv11, and the pump P0 are in the working state through electrical control. At this time, the second branch 9 where the three-way valve Sv9 is located is in the open state, and the first branch 8 where the three-way valve Sv9 is located is in the closed state. Deionized water flows through the two-way valve Sv11 under the action of the P0 pump, passes through the P0 pump, and part of the deionized water enters the conventional cleaning needle to clean the colorimetric cup through the two-way valves Sv4 and Sv5. Another part of the deionized water flows through the three-way valve Sv9 and pushes the previously stored small amount of alkaline cleaning liquid into the alkaline cleaning needle through the two-way valve Sv3 to clean the colorimetric cup, achieving the purpose of cleaning the colorimetric cup under the alkaline cleaning needle first with alkaline liquid and then with deionized water.

[0036] The present invention controls the transportation of deionized water and alkaline cleaning liquid through the two-way valves Sv11, Sv4, Sv5, Sv3, Sv10, Sv6, Sv7, the pump P0, and the three-way valve Sv9. The above solenoid valves and pumps are electrically connected to respectively complete the control of the on-off of the liquid path and the power source of the liquid path transportation, and only rely on them to realize the cleaning of the colorimetric cup and the probe, and at the same time add alkaline cleaning liquid to the colorimetric cup at a single position for cleaning. The alkaline cleaning liquid only enters the colorimetric cup through the third elbow Q7 each time, and there will be no alkaline cleaning liquid in the adjacent cleaning position and the probe cleaning tank, which not only realizes the supply of alkaline cleaning liquid for a single cleaning needle, but also has a simple structure and low cost.

[0037] The present invention realizes the injection of alkaline cleaning liquid for a single cleaning needle through the three-way solenoid valve Sv9 and the pump P0, with a simple structure, greatly saving costs, reducing the complexity of the liquid path, and improving the stability of the liquid path system.

[0038] The present invention also discloses a liquid supply method for a liquid path, and the method includes the following steps:

[0039] The extracted alkaline cleaning solution flows from the alkaline cleaning solution supply liquid path to the branch; the extracted deionized water flows from the deionized water supply liquid path to the branch, and the deionized water carries the alkaline cleaning solution on the branch and flows through the alkaline cleaning solution supply liquid path to the alkaline solution cleaning needle.

[0040] Specifically, when extracting the alkaline cleaning solution, the alkaline cleaning solution flows from the alkaline cleaning solution supply liquid path to the first branch; when extracting the deionized water, the deionized water flows through the deionized water supply liquid path and the second branch to the first branch, and the deionized water carries the alkaline cleaning solution on the first branch and flows through the alkaline cleaning solution supply liquid path to the alkaline solution cleaning needle.

[0041] Further, when extracting the alkaline cleaning solution, the alkaline cleaning solution is extracted by the pump P0 and flows from the alkaline cleaning solution supply liquid path to the three-way valve Sv9; when extracting the deionized water, the deionized water is extracted by the pump P0 and flows through the deionized water supply liquid path, the second branch, and the three-way valve Sv9 to the first branch, and the deionized water carries the alkaline cleaning solution on the first branch and flows through the alkaline cleaning solution supply liquid path to the alkaline solution cleaning needle.

[0042] The above are only the embodiments of the present invention and are not used to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention are included in the scope of the claims of the present invention pending approval.

Claims

1. A liquid path distribution system, characterized in that, It includes a deionized water storage device, an alkaline cleaning solution storage device, a cleaning needle assembly, and a dispensing liquid path; the cleaning needle assembly includes an alkaline solution cleaning needle and a conventional cleaning needle; The dispensing liquid path includes an alkaline cleaning solution supply liquid path, a deionized water supply liquid path, and a branch; one end of the alkaline cleaning solution supply liquid path is connected to the alkaline solution cleaning needle, and the other end is connected to the alkaline cleaning solution storage device; One end of the deionized water supply liquid path is connected to the conventional cleaning needle, and the other end is connected to the deionized water storage device; the branch is connected between the alkaline cleaning solution supply liquid path and the deionized water supply liquid path; the branch includes a first branch and a second branch; one end of the first branch is connected to the alkaline cleaning solution supply liquid path and the other end is connected to the deionized water supply liquid path; one end of the second branch is connected to the first branch and the other end is connected to the deionized water supply liquid path; along the flowing direction of the deionized water, a two-way valve Sv11 and a pump P0 are sequentially arranged on the deionized water supply liquid path; along the flowing direction of the alkaline cleaning solution, a two-way valve Sv10 and a two-way valve Sv3 are sequentially arranged on the alkaline cleaning solution supply liquid path; a three-way valve Sv9 is arranged on the first branch.

2. The liquid path distribution system according to claim 1, wherein One end of the first branch is connected to the deionized water supply liquid path between the pump P0 and the two-way valve Sv11, and the other end is connected to the alkaline cleaning solution supply liquid path between the two-way valve Sv3 and the two-way valve Sv10; the deionized water supply liquid path on the side of the pump P0 away from the two-way valve Sv11 is connected to the three-way valve Sv9 through the second branch.

3. A liquid path distribution system according to claim 2, characterized in that, There are two conventional cleaning needles, which are respectively connected to the deionized water supply liquid path through a first elbow Q3 and a second elbow Q5; a two-way valve Sv5 is arranged on the pipeline of the first elbow Q3, and a two-way valve Sv4 is arranged on the pipeline of the second elbow Q5; the alkaline solution cleaning needle is connected to the two-way valve Sv3 through a third elbow Q7.

4. A liquid path distribution system according to any one of claims 1-3, characterized in that, It further includes a probe assembly and a probe cleaning pool; the probe assembly is connected to the deionized water storage device through a probe liquid path; the probe cleaning pool is connected to the deionized water supply liquid path through the deionized water supply liquid path.

5. A liquid supply method for a liquid path, characterized in that, The liquid path includes an alkaline cleaning solution supply liquid path, a deionized water supply liquid path, and a branch; the branch is connected between the alkaline cleaning solution supply liquid path and the deionized water supply liquid path; the method includes the following steps: Extract the alkaline cleaning solution to flow from the alkaline cleaning solution supply liquid path to the branch; Extract deionized water to flow through the deionized water supply liquid path to the branch, and the deionized water carries the alkaline cleaning solution on the branch to flow through the alkaline cleaning solution supply liquid path to the alkaline solution cleaning needle; The branch includes a first branch and a second branch; one end of the first branch is connected to the alkaline cleaning solution supply liquid path and the other end is connected to the deionized water supply liquid path; one end of the second branch is connected to the first branch and the other end is connected to the deionized water supply liquid path; When extracting the alkaline cleaning solution, the alkaline cleaning solution flows from the alkaline cleaning solution supply liquid path to the first branch; When extracting deionized water, the deionized water flows through the deionized water supply liquid path and the second branch to the first branch, and the deionized water carries the alkaline cleaning solution on the first branch to flow through the alkaline cleaning solution supply liquid path to the alkaline solution cleaning needle; A pump P0 is provided between the connection nodes of the first branch, the second branch and the deionized water supply liquid path; a three-way valve Sv9 is provided at the connection node of the first branch and the second branch; When extracting the alkaline cleaning liquid, the alkaline cleaning liquid is extracted by the pump P0 and flows from the alkaline cleaning liquid supply liquid path to the three-way valve Sv9; When extracting deionized water, the deionized water is extracted by the pump P0 and flows through the deionized water supply liquid path, the second branch, and the three-way valve Sv9 to the first branch. The deionized water carries the alkaline cleaning liquid on the first branch and flows through the alkaline cleaning liquid supply liquid path to the alkaline cleaning needle.

6. An automatic biochemical analyzer, characterized in that, It includes the liquid path distribution system according to any one of claims 1-4.

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