Interventional devices and medical equipment for implanting electrodes into the brain through blood vessels

Abstract

The present disclosure relates to an interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a vascular channel and a vascular wall. The interventional device comprises: a first guide, the distal end of which is capable of distally moving within the vascular channel and establishing a first support point in the vascular channel; a second guide, the distal end of which is capable of passing through the first guide, distally moving within the vascular channel, and establishing a second support point in the vascular channel, such that the second guide extends in an arcuate manner between the first and second support points; and a puncture kit for carrying an electrode, the distal end of which is capable of passing through the first guide, distally moving within the vascular channel, and puncturing the vascular wall in a target puncture area between the first and second support points, thereby implanting the carried electrode into the brain. The present disclosure also relates to a medical device.

Description

Technical Field

[0001] The present disclosure relates to the field of medical devices, and more particularly, to an interventional device for implanting an electrode into the brain through a blood vessel and a medical apparatus. Background Art

[0002] In the field of brain-computer interface technology, electrodes (such as flexible electrode wires) are widely used. Electrodes can be implanted into the brain to collect neuronal signals near the electrodes. The current solution for implanting electrodes in the brain is to first perform bone removal and windowing on the skull through surgery, open the dura mater to expose the target implantation area on the cerebral cortex, and then implant the electrodes by machine or manually. However, when such a solution for implanting electrodes in the brain encounters a target implantation area that is a functional area deep in the brain rather than the cortex, it will inevitably lead to damage to nerve cells in non-target areas and may even cause brain damage. Therefore, it is necessary to find a new solution for implanting electrodes into the brain, especially deep in the brain. Summary of the Invention

[0003] A brief overview of the present disclosure is provided below to provide a basic understanding of some aspects of the present disclosure. However, it should be understood that this overview is not an exhaustive overview of the present disclosure. It is not intended to identify key or important parts of the present disclosure, nor is it intended to limit the scope of the present disclosure. Its purpose is simply to present certain concepts of the present disclosure in a simplified form as a prelude to the more detailed description that will be given later.

[0004] According to a first aspect of the present disclosure, an interventional device for implanting an electrode into the brain through a blood vessel is provided, wherein the blood vessel has a vascular channel and a vascular wall, wherein the interventional device includes: a first guide, the distal end of the first guide being capable of moving distally within the vascular channel and establishing a first support point in the vascular channel; a second guide, the distal end of the second guide being capable of passing through the first guide, moving distally within the vascular channel, and establishing a second support point in the vascular channel, so that the second guide extends in an arc shape between the first support point and the second support point; and a puncture kit, the puncture kit being used to carry the electrode, and the distal end of the puncture kit being capable of passing through the first guide, moving distally within the vascular channel, and puncturing the vascular wall in a target puncture area between the first support point and the second support point, thereby implanting the carried electrode into the brain.

[0005] According to a second aspect of the present disclosure, there is provided an interventional device for implanting an electrode into the brain through a blood vessel, the blood vessel comprising a first blood vessel segment and a second blood vessel segment extending in different directions, the interventional device comprising: a first guide, the distal end of the first guide being capable of moving distally within the vascular channel of the first blood vessel segment and reaching a first position, the first position being in the first blood vessel segment and located near the connection between the first and second blood vessel segments; a second guide, the distal end of the second guide being capable of moving distally in the first guide and continuing to move distally after reaching the distal end of the first guide, so as to pass through the connection between the first and second blood vessel segments and enter the second blood vessel segment, thereby reaching and being fixed at the second position; and a puncture kit, the puncture kit being used to carry the electrode, and the distal end of the puncture kit being capable of moving distally in the first guide and continuing to move distally after reaching the distal end of the first guide, so as to puncture the blood vessel wall between the first position and the second position, thereby implanting the carried electrode into the brain.

[0006] According to a third aspect of the present disclosure, an interventional device for implanting an electrode into the brain through a blood vessel is provided, wherein the blood vessel comprises a first blood vessel segment and a second blood vessel segment that are connected and extend in different directions, the connection between the first blood vessel segment and the second blood vessel segment is near the brain, and the interventional device comprises: a first catheter, the first catheter is configured so that its distal end can reach and float at a first position located in the first blood vessel segment, and the opening of the distal end of the first catheter is basically facing a first direction, the first position is located near the connection, and the first direction is the direction in which the first blood vessel segment extends near the connection; a stent assembly, the stent assembly comprises a stent located at the distal end and a stent pushing rod connected to the stent, the stent assembly is configured so that the stent can reach the distal end of the first catheter along the lumen of the first catheter, pass through the connection and enter the second blood vessel segment, and be fixed at a second position located in the second blood vessel segment so that the stent pushing rod can The first position and the second position extend along the branch direction of the blood vessel, and the opening of the distal end of the first catheter is deflected toward the second direction under the action of the stent pushing rod, and the second direction is the direction of extension of the second blood vessel segment near the connection; the third catheter, the third catheter is configured so that its distal end can reach and extend from the distal end of the first catheter along the lumen of the first catheter to approach the puncture position on the blood vessel wall; and the puncture kit, the puncture kit is used to carry the electrode, and the puncture kit is configured so that its distal end can approach the distal end of the third catheter along the lumen of the third catheter, wherein the third catheter is also configured so that after the distal end of the puncture kit approaches the distal end of the third catheter, the distal end of the third catheter can puncture the blood vessel wall at the puncture position and reach outside the blood vessel but not enter the brain, and the puncture kit is also configured so that after the distal end of the third catheter reaches outside the blood vessel, it continues to move along the lumen of the third catheter and passes through the distal end of the third catheter to enter the brain, thereby implanting the carried electrode into the brain.

[0007] According to a fourth aspect of the present disclosure, an interventional device for implanting an electrode into the brain via a blood vessel is provided, wherein the blood vessel comprises a first blood vessel segment and a second blood vessel segment that are connected and extend in different directions, the connection between the first blood vessel segment and the second blood vessel segment is near the brain, and the interventional device comprises: a first catheter, the first catheter is configured so that its distal end can reach and be located in a first position in the first blood vessel segment, the first position being located near the connection; a stent assembly, the stent assembly comprising a stent at the distal end and a stent pushing rod connected to the stent, the stent assembly being configured so that the stent can reach the distal end of the first catheter along the lumen of the first catheter and pass through the connection The stent is connected to the stent and enters the second blood vessel segment, and is fixed at a second position in the second blood vessel segment, so that the stent pushing rod extends between the first position and the second position; a second catheter, the second catheter is configured to be able to be sleeved outside the stent pushing rod and the distal end of the second catheter can reach and be located at a specific position between the first position and the second position; and a puncture kit, the puncture kit is used to carry the electrode, and the puncture kit is configured so that its distal end can reach the distal end of the second catheter along the lumen of the second catheter and continue to move after passing the distal end of the second catheter, so as to puncture the blood vessel wall at the puncture position corresponding to the specific position and enter the brain, thereby implanting the carried electrode into the brain.

[0008] According to a fifth aspect of the present disclosure, an interventional device for implanting an electrode into the brain via a blood vessel is provided, wherein the blood vessel comprises a first blood vessel segment and a second blood vessel segment that are connected and extend in different directions, the connection between the first blood vessel segment and the second blood vessel segment is near the brain, and the interventional device comprises: a first catheter, the first catheter is configured so that its distal end can reach and float at a first position located in the first blood vessel segment, and the opening of the distal end of the first catheter is substantially facing a first direction, the first position is located near the connection, and the first direction is the direction in which the first blood vessel segment extends near the connection; a stent assembly, the stent assembly comprises a stent located at the distal end and a stent pushing rod connected to the stent, and the stent assembly is configured The stent is capable of reaching the distal end of the first catheter along the lumen of the first catheter, passing through the connection and entering the second blood vessel segment, and being fixed at a second position in the second blood vessel segment, so that the stent pushing rod extends along the branch direction of the blood vessel between the first position and the second position, and the opening of the distal end of the first catheter is deflected toward a second direction under the action of the stent pushing rod, and the second direction is the direction in which the second blood vessel segment extends near the connection; and an electrode guide needle, the distal end of the electrode guide needle is constructed to carry an electrode, and the electrode guide needle is configured so that its distal end can reach and extend from the distal end of the first catheter along the lumen of the first catheter, pass through the blood vessel wall at the puncture position on the blood vessel wall to enter the brain, thereby implanting the carried electrode into the brain.

[0009] According to a sixth aspect of the present disclosure, a medical device is provided, comprising an interventional apparatus for implanting an electrode into the brain through a blood vessel according to the present disclosure.

[0010] Other features and advantages of the present disclosure will become more apparent from the following detailed description of exemplary embodiments of the present disclosure with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] The accompanying drawings, which constitute a part of the specification, illustrate embodiments of the present disclosure and, together with the description, serve to explain the principles of the present disclosure. The embodiments illustrated in the drawings are illustrative and exemplary in nature and are not intended to limit the present disclosure. The following detailed description of the exemplary embodiments will be clearly understood when read in conjunction with the following drawings, in which like structures are indicated by like 1, and in which:

[0012] Figure 1 is a perspective view schematically illustrating a human brain;

[0013] Figure 2 is a perspective view schematically illustrating an interventional device for implanting an electrode into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure;

[0014] Figure 3 is a perspective view schematically illustrating an interventional device for implanting an electrode into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure, wherein the electrode has been implanted into the brain;

[0015] Figures 4A to 4C Three exemplary electrode guide needles of an interventional device for implanting an electrode into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure are respectively shown;

[0016] Figures 5A to 5C Three exemplary occluders provided with an interventional device for implanting an electrode into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure are respectively shown;

[0017] Figures 6A to 6G is a schematic diagram schematically illustrating the use of an interventional device for implanting an electrode into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure;

[0018] 7A to 7F FIG2 is a schematic diagram schematically illustrating the use of an interventional device for implanting an electrode into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure.

[0019] Figure 8A and Figure 8B Schematic diagram showing a puncture kit according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0020] Various exemplary embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings. It should be noted that unless otherwise specifically stated, the relative arrangements of components and steps, numerical expressions and numerical values ​​set forth in these embodiments do not limit the scope of the present disclosure.

[0021] The following description of at least one exemplary embodiment is merely illustrative and is not intended to limit the present disclosure, its application, or use. In other words, the structures and methods herein are presented in an exemplary manner to illustrate various embodiments of the structures and methods of the present disclosure. However, those skilled in the art will appreciate that these are merely exemplary of the disclosure that may be implemented, and are not exhaustive. Furthermore, the drawings are not necessarily drawn to scale, and some features may be exaggerated to illustrate details of specific components.

[0022] In addition, technologies, methods and devices known to ordinary technicians in the relevant field may not be discussed in detail, but where appropriate, such technologies, methods and devices should be considered part of the authorization specification.

[0023] In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not limiting. Therefore, other examples of the exemplary embodiments may have different values.

[0024] Figure 1 The human brain is shown schematically.

[0025] like Figure 1 As shown, in the present disclosure, in order to facilitate the explanation of the technical solution, the human brain is schematically divided into a superficial brain area 1 located in the superficial layer (surface layer) of the brain and a deep brain area 5 located in the deep layer of the brain. The superficial brain area 1 may include the cerebral cortex (cerebral cortex). In the cerebral cortex, there are functional areas such as movement and vision. The deep brain area 5 may include deep brain nuclei, which include important functional areas such as the nucleus accumbens, caudate nucleus, putamen, globus pallidus, red nucleus, dentate nucleus, ventroposterior lateral nucleus, ventroposterior medial nucleus, and ventroposterior nucleus. In addition, it can be understood that there are multiple blood vessels in the superficial brain area 1 and the deep brain area 5 of the human brain. The multiple blood vessels may include a main blood vessel 3, a branch blood vessel 4, and a transition area 2 between the main blood vessel 3 and the branch blood vessel 4. Among them, the branch blood vessel 4 extends from the main blood vessel 3 to the branch, and the connection between the main blood vessel and the branch blood vessel (see Figure 6A The connection C) is located near the brain (eg, deep brain region 5). Each blood vessel has a vascular channel 6 and a vascular wall 7.

[0026] refer to Figure 1Those skilled in the art of brain-computer interfaces will understand that the technical solution for implanting electrodes 32 through craniotomy described at the beginning of this article is only applicable to implanting electrodes 32 into the superficial brain region 1, and is not applicable to implanting electrodes 32 into the deep brain region 5. Furthermore, such a technical solution requires both craniotomy and deep brain region implantation surgery, which not only causes significant trauma to the patient but also places a huge workload on the doctor.

[0027] To this end, the present disclosure provides an interventional device 100 for implanting an electrode 32 into the brain via a blood vessel (e.g., a cerebral vein, etc.). The interventional device can implant an electrode 32 into the brain of a living organism (e.g., a human or animal) through at most two vascular punctures, such as a jugular vein puncture and an intracranial vein puncture. This not only significantly reduces the trauma caused to the patient (only two vascular puncture openings are required), but also reduces the workload of the physician. Moreover, since blood vessels are distributed in almost all areas of the brain, the electrode 32 can be implanted into almost any area of ​​the brain through the corresponding blood vessels. Taking the subthalamic nucleus (STN) in the deep brain region 5 as an example, the interventional device 100 can establish an electrode implantation path starting from the jugular vein, passing through the sigmoid sinus to the transverse sinus, then through the sinus confluence to the straight sinus, and finally through the vein of Galen and the thalamostriatal vein, implanting the electrode 32 into the subthalamic nucleus. Furthermore, the electrodes implanted using the interventional device 100 of the present disclosure can have both the function of collecting neuronal signals and the function of stimulating neurons. Therefore, the interventional device 100 according to the present disclosure not only supports the acquisition of neuronal signals and stimulation of neurons in the superficial brain region 1, but also supports the acquisition of neuronal signals and stimulation of neurons in the deep brain region 5. In addition, the interventional device 100 according to the present disclosure can specifically set or adjust the needle insertion direction or target puncture area of ​​the puncture needle in the puncture kit by determining or adjusting the positions of the first support point a and the second support point b, thereby providing a relatively stable puncture track for the electrode guide needle 103 of the interventional device 100, thereby improving the accuracy of electrode 32 implantation.

[0028] The following will be combined with the Figures 2 to 5C The following describes in detail an interventional device 100 for implanting an electrode 32 into the brain via a blood vessel according to various embodiments of the present disclosure. It is understood that the actual interventional device 100 may have other components, and to avoid obscuring the key points of the present disclosure, these other components are not shown in the drawings and will not be discussed herein. It should also be noted that, in this document, reference to the "distal end" or "distal side" refers to the end or side that is away from the operator / surgeon (usually a physician), and reference to the "proximal end" or "proximal side" refers to the end or side that is closer to the operator / surgeon (usually a physician).

[0029] Figure 2 and Figure 3 The figure schematically shows an interventional device 100 for implanting an electrode 32 into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure, wherein: Figure 2 It is mainly used to illustrate the arrangement structure of the interventional device 100. Figure 3 It is mainly used to illustrate the electrode 32 implanted in the brain and the occluder 103 - 8 for blocking the punctured blood vessel wall 7 .

[0030] like Figure 2 As shown, an interventional device 100 for implanting an electrode 32 into the brain through a blood vessel according to the present disclosure may include a first guide member 101, a second guide member 102, and an electrode guide needle 103. The first guide member 101 may be configured to be capable of percutaneous intervention in a blood vessel of a living body (e.g., a human body or an animal body), and has a distal end 101-1 and a proximal end 101-2 opposite to the distal end 101-1. The distal end 101-1 of the first guide member 101 is capable of distally moving within a vascular channel 6 of the blood vessel and establishing a first support point a in the vascular channel 6. Similar to the first guide member 101, the second guide member 102 also has a distal end 102-1 and a proximal end 102-2 opposite to the distal end 102-1, and the electrode guide needle 103 also has a distal end 103-1 and a proximal end 103-2 opposite to the distal end 103-1. The distal end 102-1 of the second guide member 102 can pass through the first guide member 101 and move distally in the vascular channel 6 of the blood vessel, and establish a second support point b in the vascular channel 6, so that the second guide member 102 extends in an arc between the first support point a and the second support point b. The distal end of the electrode guide needle 103 is constructed to carry the electrode 32, and the distal end of the electrode guide needle 103 can pass through the first guide member 101 and move distally in the vascular channel 6 and puncture the vascular wall 7 of the blood vessel in the target puncture area between the first support point a and the second support point b, thereby implanting the carried electrode 32 into the brain. In some embodiments, the electrode 32 can be a flexible electrode, such as an electrode wire. The electrode 32 should have a sufficient length so that the proximal end of the electrode can be connected to an external data interface, so that the neuronal signals collected by the brain can be transmitted to the data interface. It can be understood that although Figure 2 The cross-sectional shapes of the bodies of the first guide 101, the second guide 102 and the electrode guide needle 103 are illustrated as circles, but this is merely exemplary and not restrictive, and the bodies of the first guide 101, the second guide 102 and the electrode guide needle 103 may have any suitable cross-sectional shape.

[0031] In some embodiments, as Figure 1As shown, the blood vessel may include a main blood vessel 3 and a branch blood vessel 4. The first support point a may be established in the main blood vessel 3, and the second support point b may be established in the branch blood vessel 4. Here, the main blood vessel 3 may be a blood vessel with a diameter of approximately 3 mm to 6 mm, and the branch blood vessel 4 may be a blood vessel with a diameter of less than 2 mm to 3 mm. Thus, the interventional device 100 may establish the first support point a and the second support point b at the natural bifurcation structure of the blood vessel, so that the second guide member 102 extends in an arc shape between the first support point a and the second support point b. Considering that the second guide member 102 forms a nested structure with the first guide member 101, the arc-shaped extension direction of the second guide member 102 may cause the distal end 101-1 of the first guide member 101 to be slightly bent toward the second guide 102, for example, see Figure 2 and Figure 3 . Considering that the electrode guide needle 103 and the first guide member 101 also form a nested structure, when the first guide member 101 determines the extension direction of its main body, especially its distal end 101-1, the insertion direction of the electrode guide needle 103 or the target puncture area is also basically determined accordingly. Here, the insertion direction of the electrode guide needle 103 or the target puncture area is basically in the angle area h formed by the central axis 101-4 of the first guide member 101 and the second guide member 102. When the first support point a is located in the main vessel 3 and the second support point b is located in the branch vessel 4, the target puncture area can be located in the transition area 2 between the main vessel 3 and the branch vessel 4. Therefore, according to the interventional device 100 of the present disclosure, the insertion direction of the electrode guide needle or the target puncture area can be set or adjusted in a targeted manner by determining or adjusting the positions of the first support point a and the second support point b. Based on this, the interventional device 100 according to the present disclosure can provide a relatively stable puncture track for the electrode guide needle 103, thereby improving the accuracy of the electrode 32 implantation.

[0032] In some embodiments, the first guide member 101 can be configured as a supporting catheter, wherein the outer diameter of the distal end 101-1 of the supporting catheter is substantially equal to the inner diameter of the blood vessel at the first supporting point a, so as to establish the first supporting point a in the blood vessel channel 6. In other embodiments, such as Figure 2As shown, the outer diameter of the distal end 101-1 of the support catheter can also be configured to be smaller than the inner diameter of the blood vessel at the first support point a. Furthermore, the support catheter can have a hollow structure to provide a first working channel (not shown) for the second guide member 102 and a second working channel (not shown) for the electrode guide needle 103 within the support catheter. That is, the second guide member 102 and the electrode guide needle 103 are removably disposed within their respective working channels. Thus, the second guide member 102 and the electrode guide needle 103 can be guided independently within the support catheter. In some alternative embodiments, the support catheter can also provide a third working channel within the support catheter for the second guide member 102 and the electrode guide needle 103. That is, the second guide member 102 and the electrode guide needle 103 are removably disposed within a common working channel. This simplifies the structure of the support catheter. The support catheter can be made of any suitable material, for example, a biomedical metal material, including but not limited to one or more of stainless steel, synthetic fiber, carbon fiber, titanium alloy, gold, silver, and the like. To facilitate bending of the distal end 101-1 of the support catheter, the distal end 101-1 of the support catheter may have a lower material hardness than the proximal end 101-2 of the support catheter. In some embodiments, the distal end 101-1 of the support catheter may be configured with a first imaging mark to facilitate positioning of the first support point a under imaging.

[0033] In some embodiments, the second guide member 102 can be supported or tensioned on the blood vessel wall 7 at the second support point b, so that the blood vessel wall 7 at the second support point b is tightened. Thereby, a fixed or anchored second support point b is established in the blood vessel channel 6. On the other hand, the tightening of the blood vessel wall 7 helps the electrode guide needle 103 to smoothly pierce the blood vessel wall 7 (or, as described below, pass through the blood vessel wall 7 with the help of the puncture needle 21). In some embodiments, in order to establish the second support point b, the second guide member 102 can be constructed as a stent assembly, which includes a guide wire (not shown), a guide catheter 102-3 and a support stent 102-4, wherein the guide wire is used to guide the guide catheter 102-3, the guide catheter 102-3 is used to guide the support stent 102-4, and the support stent 102-4 is used to support the blood vessel wall 7. Specifically, the stent assembly can establish the second support point b through the following steps: first, the distal end of the guide guidewire of the stent assembly is delivered to the second support point b through the working channel of the supporting catheter; then, the distal end of the guide catheter 102-3 of the stent assembly is delivered to the second support point b along the guide guidewire, and the guide guidewire is withdrawn, but the guide catheter 102-3 is retained; then, the supporting stent 102-4 of the stent assembly is pushed to the second support point b, and the guide catheter 102-3 is withdrawn, so that the supporting stent 102-4 is opened at the second support point b and supported on the blood vessel wall 7.

[0034] The guide wire can have any suitable elongated structure. In some embodiments, the guide wire can have a tapered outer diameter, for example, tapering from the proximal end to the distal end. The guide wire can be made of a metal material, including but not limited to stainless steel, aluminum alloy, tungsten, etc. In addition, to facilitate pushing, the proximal end of the guide wire can have a greater material hardness than the distal end of the guide wire. Furthermore, the distal end of the guide wire can also be shaped.

[0035] In some embodiments, in order to deliver the distal end of the guide catheter 102-3 to the second support point b along the guide wire, the guide catheter 102-3 can be sleeved on the guide wire and can move along the guide wire. In order to be sleeved on the guide wire, the inner diameter of the guide catheter 102-3 can be configured to be greater than or equal to the outer diameter of the guide wire. In addition, in order to facilitate pushing, the proximal end of the guide catheter 102-3 can have a greater material hardness than the distal end of the guide catheter 102-3. The guide catheter 102-3 can be made of any suitable material, for example, it can be made of one or more of the following materials: acrylonitrile butadiene styrene (ABS), polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), polymethylpentene (PMP), polymethyl methacrylate (PMMA); polycarbonate (PC), polyphenylene oxide (PPO), modified phenylene oxide (modified PPO), polyphenylene ether (PPE); polyimide (PI), polybenzimidazole (PBI); polyphenylene sulfide (PPS), polyetheretherketone (PEEK); fluorinated ethylene-propylene (FEP), ethylene-chlorotrifluoroethylene (ECTFE), ethylene, ethylene-tetrafluoroethylene (ETFE), polychlorotrifluoroethylene (PCTFE), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), polyvinylidene fluoride (PVDF); elastomeric silicone polymer, polyether front segment amide or thermoplastic copolyether (PEBAX); metal (such as stainless steel and nickel titanium alloy), etc. The distal end of the guide catheter 102 - 3 may be configured with a second visualization marker to facilitate positioning under imaging.

[0036] In some instances, in order for the support stent 102-4 to automatically expand after the guide catheter 102-3 is withdrawn, the support stent 102-4 may be constructed as a self-expanding stent. The self-expanding stent may include a first pushing rod on the proximal side and a stent body 102-4-1 on the distal side, wherein the first pushing rod is used to push the stent body 102-4-1 through the guide catheter 102-3, and the stent body 102-4-1 can rely on the self-expansion force to radially open and support on the blood vessel wall 7 after leaving the guide catheter 102-3. In order for the stent body 102-4-1 to leave the guide catheter 102-3, the guide catheter 102-3 may be withdrawn, or the stent body 102-4-1 may be further pushed distally by the first pushing rod. In order to form a self-expanding force, the stent body 102-4-1 of the self-expanding stent may be made of a memory alloy material. In some embodiments, such as Figure 2 As shown, the stent body 102-4-1 can include multiple closed-loop mesh units and multiple open-loop mesh units. To ensure smooth passage of the self-expanding stent through the guide catheter 102-3, the outer diameter of the self-expanding stent in its compressed state can be configured to be smaller than or substantially equal to the inner diameter of the guide catheter 102-3. A third imaging marker can be configured on the stent body 102-4-1 of the self-expanding stent to facilitate imaging and locating the second support point b.

[0037] Figures 4A to 4C The electrode guide needle 103 of the interventional device 100 for implanting the electrode 32 into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure is schematically shown. Figures 4A to 4C The embodiment of the present invention differs only in the mating portion 103-7. Therefore, in order to facilitate the reader's understanding and comparison, Figures 4A to 4C The same reference numerals are used in FIG.

[0038] In some embodiments, as Figure 2 and Figures 4A to 4C As shown, the electrode guide needle 103 can be removably disposed in the working channel of the supporting catheter and can include a proximal second push rod 103-6 and a distal mating portion 103-7 for the electrode 32. In order to achieve mating between the electrode 32 and the electrode guide needle 103, a hole can be constructed on the electrode 32; the mating portion 103-7 of the electrode guide needle 103 can be constructed as a tip, which can pass through the hole of the electrode 32. In some embodiments, as Figure 4A and Figure 4B As shown in FIG, the tip may have a stepped structure so that the tip can carry the electrode 32 when it moves distally, and the electrode 32 can fall off the tip when it is retracted proximally after being implanted in the brain. Figure 4CAs shown, the tip may also have a cone-shaped structure. The electrode guide needle 103 may be made of any suitable metal material, for example, it may be made of biomedical metal materials, including but not limited to stainless steel or tungsten. In some embodiments, as Figure 2 As shown, the electrode guide needle 103 can be equipped with a puncture catheter 103-5 for guiding the puncture needle 103 to the target puncture area. In some embodiments, the puncture needle 103 can first be guided to a position about 0.5 mm, 1 mm, 1.5 mm or 2 mm from the target puncture area by the puncture catheter 103-5 and then stopped, and then the second pushing rod 103-6 of the puncture needle 103 is quickly pushed to make the puncture needle 103 pierce the blood vessel wall 7. In some embodiments, as Figure 2 As shown, the puncture catheter 103-5 can be sheathed on the puncture needle 103 and can puncture the blood vessel wall 7. The puncture catheter 103-5 can be formed of the same material as the first guide member 101 configured to support the catheter.

[0039] In some embodiments, Figure 2 The reference numeral 103-5 in the figure may be a puncture needle provided for the electrode guide needle 103. The puncture needle has a tip that can pierce the wall of a blood vessel, and has a cavity inside to accommodate the electrode guide needle 103 carrying the electrode. The puncture needle is used to pierce the blood vessel so that the electrode guide needle 103 carrying the electrode passes directly through the puncture hole, which can protect the electrode guide needle 103 and the electrode it carries. The puncture needle can be made of any suitable metal material, for example, it can be made of biomedical metal materials, including but not limited to one or more of stainless steel, synthetic fiber, carbon fiber, titanium alloy, gold, silver, tungsten, etc. The puncture needle and the electrode guide needle 103 together constitute a puncture kit. In some embodiments, a needle sheath can also be provided for the puncture needle. The needle sheath is placed on the outside of the puncture needle to protect the tip of the puncture needle to prevent the tip of the puncture needle from puncturing the catheter (such as the first guide 101).

[0040] Figures 5A to 5C Several exemplary occluders 103-8 are shown for use in a puncture kit of an interventional device 100 for implanting an electrode 32 into the brain through a blood vessel according to one or more exemplary embodiments of the present disclosure. Figures 5A to 5C The embodiment of the present invention differs only in the blocking structure 103-8-2. Therefore, in order to facilitate the reader's understanding and comparison, Figures 5A to 5C The same reference numerals are used in FIG.

[0041] In some embodiments, the puncture kit can be equipped with an occluder 103-8 for occluding the punctured vessel wall 7. This ensures that blood and emboli do not penetrate the punctured vessel wall 7 into non-vascular areas. In some embodiments, the occluder 103-8 can be configured as a self-expanding occluder, comprising a proximal third push rod 103-8-1 and a distal blocking structure 103-8-2. The third push rod 103-8-1 is used to push the blocking structure 103-8-2 through the puncture catheter 103-5. After leaving the puncture catheter 103-5, the blocking structure 103-8-2 can radially expand and adhere to the punctured vessel wall 7 due to its self-expansion force. To allow the blocking structure 103-8-2 to exit the puncture catheter 103-5, the puncture catheter 103-5 can be withdrawn, or the third push rod 103-8-1 can push the blocking structure 103-8-2 distally. In some embodiments, the occluding structure 103-8-2 can be located on the inner side (not shown) or the outer side (see FIG. Figure 2 ) is attached to the punctured blood vessel wall 7. In order to block the outside of the blood vessel wall 7, the puncture catheter 103-5 can be as follows Figure 2 In order to form a self-expanding force, the occluding structure 103-8-2 of the self-expanding occluder can be made of a memory alloy material. Figures 5A to 5C As shown, the blocking structure 103-8-2 of the occluder 103-8 may have a flower-shaped structure, wherein: Figure 5A The middle is in the shape of a three-petal flower. Figure 5B The middle is in the shape of a four-petal flower. Figure 5C The figure depicts a five-petal flower shape. It will be appreciated that these various flower shapes are merely exemplary and non-restrictive. The occluding structure 103-8-2 of the occluder 103-8 may also have other suitable shapes, such as an umbrella, disc, ring, cylinder, or funnel. Furthermore, in some embodiments, an electrolytic release portion may be configured at the distal end of the third push rod 103-8-1 to release the occluding structure 103-8-2 from the third push rod 103-8-1 upon application of power. This allows the third push rod 103-8 to be withdrawn from the blood vessel.

[0042] According to the interventional device 100 of various embodiments of the present disclosure, the electrode 32 is implanted into the brain by establishing an electrode implantation path in the blood vessel, thereby not only reducing the trauma caused to the patient, but also reducing the workload of the doctor. Moreover, since blood vessels are distributed in almost all areas of the brain, the electrode 32 can be implanted into almost any area of ​​the brain through the corresponding blood vessels. In addition, according to the interventional device 100 of the present disclosure, the needle insertion direction or the target puncture area of ​​the puncture kit can be set or adjusted in a targeted manner by determining or adjusting the positions of the first support point a and the second support point b, thereby providing a relatively stable puncture track for the puncture kit of the interventional device 100, thereby improving the accuracy of the electrode 32 implantation. In addition, according to the interventional device 100 of the present disclosure, a closure device 103-8 for blocking the punctured blood vessel wall 7 can be provided, thereby ensuring that blood and embolism will not penetrate into the non-vascular area through the punctured blood vessel wall 7.

[0043] Figures 6A to 6G Schematically shows a schematic diagram of the use of an interventional device for implanting an electrode into the brain through a blood vessel according to another exemplary embodiment of the present disclosure. Figure 6A As shown, the direction in which the main blood vessel 3 extends near the connection point C with the branch blood vessel 4 is the first direction D1, and the direction in which the branch blood vessel 4 extends near the connection point C is the second direction D2. Figure 6B As shown, the first guide member 101 (also referred to as the "first catheter 101" in this exemplary embodiment) travels in the lumen of the main vessel 3, and its distal end is able to reach and float at a first position P1 located in the main vessel 3. The first position P1 is located near the connection C, which can correspond to the first support point a in the above-mentioned embodiment. Being "near" the connection C means that it cannot be too far away from the connection C, so that the first position P1 is suitable for other components to enter the branch vessel 4 from the first position P1 via the connection C. At this time, due to the mechanical strength of the first catheter 101 itself and the blood flow in the lumen of the main vessel 3, the opening of the distal end of the first catheter 101 is basically facing the first direction D1. The outer diameter of the distal end of the first catheter 101 is smaller than the inner diameter of the main vessel 3, so that the distal end of the first catheter 101 can float radially in the main vessel 3 to a limited extent, so that the direction of the opening of the distal end of the first catheter 101 can be changed in subsequent steps.

[0044] like Figure 6CAs shown, the stent 102-4-1 at the distal end of the stent assembly (i.e., the stent body 102-4-1 in the above embodiment) can reach the distal end of the first catheter 101 along the lumen of the first catheter 101, pass through the connection C and enter the branch blood vessel 4, and be fixed at the second position P2 located in the branch blood vessel 4. The second position P2 can also be located near the connection C, which can correspond to the second support point b in the above embodiment. The operation process of fixing the stent 102-4-1 to the second position P2 can be referred to below in conjunction with Figures 7A to 7D The operation process described. The stent assembly also includes a stent pushing rod 102-4-2 connected to the stent 102-4-1. After the stent 102-4-1 is fixed at the second position P2, the stent pushing rod 102-4-2 connected to the rear of the stent 102-4-1 is able to extend between the first position P1 and the second position P2 along the branch direction of the blood vessel, so that the opening at the distal end of the first catheter 101 is deflected toward the second direction D2 under the action of the stent pushing rod 102-4-2. In this way, the opening at the distal end of the first catheter 101 is facing the third direction D3, and the third direction D3 is in the angle region between the first direction D1 and the second direction D2 (which may be similar to the angle region h in the above embodiment).

[0045] The third catheter 103-5 is inserted from the first catheter 101 so that the distal end of the third catheter 103-5 reaches and extends out of the distal end of the first catheter 101 along the lumen of the first catheter 101 to approach the puncture position P3 on the blood vessel wall. Then, before the third catheter 103-5 pierces the blood vessel wall, the electrode guide needle 103 can be inserted into the third catheter 103-5 and the distal end of the electrode guide needle 103 can be approached to the distal end of the third catheter 103-5 along the lumen of the third catheter 103-5. After the distal end of the electrode guide needle 103 approaches the distal end of the third catheter 103-5 (it can be in the lumen of the third catheter 103-5 without extending out of the lumen, or it can be slightly extended out of the lumen of the third catheter 103-5), the distal end of the electrode guide needle 103 does not continue to move forward to avoid puncturing the blood vessel wall at this time; and, as Figure 6D As shown, the distal end of the third catheter 103-5 pierces the blood vessel wall at the puncture position P3 and reaches outside the blood vessel but does not enter the brain, and the electrode guide needle 103 continues to move along the lumen of the third catheter 103-5 and passes through the distal end of the third catheter 103-5 to enter the brain 5, thereby implanting the carried electrode 32 into the brain 5.

[0046] After the electrodes 32 are implanted in the brain 5, Figure 6FAs shown, the electrode guide needle 103 is quickly withdrawn along the lumen of the third catheter 103-5, and the occluder assembly 103-8 is sent into the third catheter 103-5, so that the blocking structure 103-8-2 included in the occluder assembly 103-8 for blocking the puncture hole on the blood vessel wall reaches the distal end of the third catheter 103-5 along the lumen of the third catheter 103-5 and opens after extending from the distal end of the third catheter 103-5. Figure 6G As shown, the third catheter 103-5 is withdrawn, and the occluder pushing rod connected to the occluding structure 103-8-2 included in the occluder assembly 103-8 is withdrawn, so that the occluding structure 103-8-2 is attached to the blood vessel wall to block the puncture hole.

[0047] 7A to 7F Schematic diagrams of the use of interventional devices for implanting electrodes into the brain through blood vessels according to other exemplary embodiments of the present disclosure are shown. In these exemplary embodiments, the interventional devices can be combined with the above Figure 6A and Figure 6B After the distal end of the first catheter 101 reaches the first position P1, the guide wire 102-5 can be inserted into the first catheter 101 and allowed to follow the lumen of the first catheter 101 to the distal end of the first catheter 101, pass through the junction C, enter the branch vessel 4, and reach the vicinity of the second position P2. Figure 7A In the example shown, the distal end of guide wire 102-5 reaches a position in branch vessel 4 that is beyond second position P2 (i.e., further than second position P2). Those skilled in the art will appreciate that in other examples, the distal end of guide wire 102-5 may reach exactly second position P2, or a position slightly closer to second position P2 in branch vessel 4. Guide wire 102-5 is relatively thin, and its distal end has good shapeability, making it easier for it to enter branch vessel 4 from main vessel 3 via junction C.

[0048] Afterwards, if Figure 7B As shown, the second catheter 102-3 is sheathed over the guide wire 102-5 and extended into the first catheter 101, and the distal end of the second catheter 102-3 is able to reach at least the second position P2 along the extension trajectory of the guide wire 102-5, that is, to the second position P2 or a position farther than the second position P2 in the branch vessel 4. Those skilled in the art will appreciate that in other embodiments, under the guidance of the guide wire 102-5, the distal end of the second catheter 102-3 may travel slightly farther than the distal end of the guide wire 102-5.

[0049] like Figure 7CAs shown, after the distal end of the second catheter 102-3 reaches at least the second position P2, the guide wire 102-5 is withdrawn along the lumen of the second catheter 102-3 so that the stent assembly can enter the second catheter 102-3. The stent assembly enters the second catheter 102-3 and the stent 102-4-1 reaches the second position P2 along the lumen of the second catheter 102-3. After the stent 102-4-1 reaches the second position P2, the second catheter 102-3 is withdrawn along the trajectory of the stent push rod 102-4-2 so that the stent 102-4-1 is exposed outside the second catheter 102-3, so that the stent 102-4-1 is fixed at the second position P2 after self-expansion; and the second catheter 102-3 is withdrawn so that the distal end of the second catheter 102-3 reaches and is at the first specific position P4-1, as shown Figure 7D As shown. The first specific position P4-1 corresponds to the first puncture position P3-1. The electrode guide needle 103 is inserted into the second catheter 102-3, and the distal end of the electrode guide needle 103 is allowed to reach the distal end of the second catheter 102-3 along the lumen of the second catheter 102-3, and continues to move after passing the distal end of the second catheter 102-3 to puncture the blood vessel wall at the first puncture position P3-1 corresponding to the first specific position P4-1, thereby entering the brain 5 to implant the carried electrode into the brain 5. It should be understood by those skilled in the art that the third catheter 103-5 can also be inserted into the second catheter 102-3 and puncture the blood vessel wall at the first puncture position P3-1, and then the electrode guide needle 103 is inserted from the third catheter 103-5 so that the electrode guide needle 103 finally reaches the brain 5.

[0050] like Figure 7E As shown, the second catheter 102-3 is retracted again, so that the distal end of the second catheter 102-3 reaches and is located at the second specific position P4-2, which corresponds to the second puncture position P3-2. The electrode guide needle 103 (or the third catheter 103-5) is inserted into the second catheter 102-3, and the distal end of the electrode guide needle 103 is moved along the lumen of the second catheter 102-3 and punctures the blood vessel wall at the second puncture position P3-2. Figure 7F As shown, the second catheter 102-3 is retracted again, so that the distal end of the second catheter 102-3 reaches and is located at the third specific position P4-3, which corresponds to the third puncture position P3-3. The electrode guide needle 103 (or the third catheter 103-5) is inserted into the second catheter 102-3, and the distal end of the electrode guide needle 103 is moved along the lumen of the second catheter 102-3 and punctures the blood vessel wall at the third puncture position P3-3.

[0051] In the case where the third catheter 103-5 is present, the occluder assembly is used in the same manner as in the above embodiment. In the case where the third catheter 103-5 is not present, for example Figures 7D to 7F In the situation shown, after the electrode guide needle 103 completes the puncture and before its distal end is withdrawn into the blood vessel, the occluder assembly can be extended into the second catheter 102-3, and the occluding structure can be moved along the lumen of the second catheter 102-3 to the distal end of the second catheter 102-3, and after passing the distal end of the second catheter 102-3, it can continue to move to the vicinity of the puncture position (a corresponding one of P3-1 to P3-3). After the distal end of the electrode guide needle 103 is withdrawn into the blood vessel, the occluding structure is quickly passed through the puncture hole at the puncture position through the blood vessel wall, and after reaching the outside of the blood vessel, it opens and adheres to the blood vessel wall to block the puncture hole. Compared to Figure 6F The occlusion method shown in the figure shortens the exposure time of the puncture hole (the time from when the electrode guide needle 103 is withdrawn from the puncture hole to when the occlusion structure occludes the puncture hole) by using the occlusion device.

[0052] In some embodiments, 7A to 7F The electrode guide needle 103 in the depicted embodiment may be implemented as Figure 8A and Figure 8B The puncture kit shown in FIG. The puncture kit includes a puncture needle 21, a needle sheath 22, and an electrode guide needle 23 for carrying an electrode 24. Figures 6A to 6G The electrode guide needle 103 in the depicted embodiment may be implemented as Figure 8A and Figure 8B The electrode guide needle 23 and the third catheter 103-5 in the puncture kit shown can be implemented as follows: Figure 8A and Figure 8B The puncture needle 21 in the puncture kit shown. The distal end of the puncture needle 21 has a tip for puncturing the blood vessel wall and the internal structure is a cavity. The puncture needle 21 can be made of any suitable metal material, for example, it can be made of biomedical metal materials, including but not limited to one or more of stainless steel, synthetic fiber, carbon fiber, titanium alloy, gold, silver, etc. The needle sheath 22 is sleeved on the outside of the puncture needle 21 to protect the tip of the puncture needle 21 to prevent the tip of the puncture needle 21 from puncturing the catheter outside the puncture needle 21. The needle sheath 22 can be made of a material softer than metal, such as the same material as the catheter. In addition, the needle sheath 22 can also be formed of metal, but is constructed to have no tip to avoid puncturing the catheter. The electrode guide needle 23 is located in the cavity of the puncture needle, and its distal end has a mating portion constructed to carry an electrode. The electrode 24 carried by the electrode guide needle 23 can be carried inside the puncture needle 21 (such as Figure 8A As shown), it can also be carried outside the puncture needle 21 and the needle sheath 22 (as shown Figure 8B shown).

[0053] The following combination 7A to 7FThe illustrated embodiment illustrates the operation of the puncture kit. The puncture kit is inserted into the second catheter 102-3, and the distal end of the puncture needle 21, the distal end of the needle sheath 22, and the distal end of the electrode guide needle 23 in the puncture kit are advanced together along the lumen of the second catheter 102-3 to reach the distal end of the second catheter 102-3. After passing (or extending beyond) the distal end of the second catheter 102-3, the distal end of the needle sheath 22 stops advancing, while the distal ends of the puncture needle 21 and the distal ends of the electrode guide needle 23 continue advancing together, extending from the needle sheath 22 and approaching the puncture site. After reaching the puncture site, the distal end of the puncture needle 21 pierces the blood vessel wall at the puncture site and exits the vessel. The distal end of the puncture needle 21 stops moving after reaching outside the blood vessel, while the distal end of the electrode guide needle 23 continues moving in the cavity of the puncture needle 21 and passes through the distal end of the puncture needle 21 to enter the brain, thereby implanting the carried electrode into the brain.

[0054] In the above description of the various embodiments of the present disclosure, the operation of the interventional device 100 is described using a scenario near the connection between a main vessel 3 and a branch vessel 4 extending from the main vessel 3. In fact, the interventional device 100 according to any of the above embodiments of the present disclosure can also operate in a scenario at the connection between a non-main vessel 3 and a branch vessel 4. For example, in other embodiments, the operation scenario of the interventional device 100 can be near the connection between a first vessel segment and a second vessel segment, where the first vessel segment extends along a first direction and the second vessel segment extends along a second direction different from the first direction. For example, the first vessel segment and the second vessel segment can be connected to form a portion of a single vessel with a curved curve and no branches.

[0055] On the other hand, the present disclosure further provides a medical device, which may include the interventional device 100 according to any of the above embodiments of the present disclosure, which will not be described in detail here.

[0056] The words "left," "right," "front," "back," "top," "bottom," "up," "down," "high," "low," and the like, if any, in the specification and claims, are used for descriptive purposes and are not necessarily intended to describe invariant relative positions. It should be understood that the words so used are interchangeable under appropriate circumstances so that the embodiments of the present disclosure described herein, for example, can operate in other orientations than those shown or otherwise described herein. For example, when the device in the figures is turned over, features previously described as "above" other features could now be described as "below" the other features. The device can also be otherwise oriented (rotated 90 degrees or in other orientations) and relative spatial relationships will be interpreted accordingly.

[0057] In the specification and claims, when an element is referred to as being "on," "attached" to, "connected" to, "coupled" to, "coupled to," or "in contact with," the element may be directly on, directly attached to, directly connected to, directly coupled to, directly coupled to, or directly in contact with, another element, or one or more intervening elements may be present. In contrast, when an element is referred to as being "directly" "on," "directly attached" to, "directly connected" to, "directly coupled" to, "directly coupled to," or "in direct contact with," another element, there may be no intervening elements. In the specification and claims, when a feature is arranged "adjacent" to another feature, it may mean that the feature has a portion that overlaps with the adjacent feature or a portion that is located above or below the adjacent feature.

[0058] As used herein, the word "exemplary" means "serving as an example, instance, or illustration," rather than as a "model" to be precisely copied. Any implementation described as exemplary is not necessarily to be construed as preferred or advantageous over other implementations. Furthermore, this disclosure is not to be bound by any expressed or implied theory presented in the technical field, background, summary, or detailed description.

[0059] As used herein, the term "substantially" is intended to encompass any minor variations due to design or manufacturing imperfections, device or component tolerances, environmental influences, and / or other factors. The term "substantially" also allows for deviations from a perfect or ideal condition due to parasitic effects, noise, and other practical considerations that may be present in actual implementations.

[0060] Additionally, terms such as "first," "second," and the like may also be used herein for reference purposes only and are not intended to be limiting. For example, the terms "first," "second," and other numerical terms referring to structures or elements do not imply a sequence or order unless the context clearly indicates otherwise.

[0061] It should also be understood that when the term “include / comprises” is used in this document, it indicates the presence of the specified features, integers, steps, operations, units and / or components, but does not exclude the presence or addition of one or more other features, integers, steps, operations, units and / or components and / or their combinations.

[0062] In this disclosure, the term "provide" is used in a broad sense to cover all ways of obtaining an object, and thus "providing an object" includes but is not limited to "purchasing", "preparing / manufacturing", "arranging / setting up", "installing / assembling", and / or "ordering" an object, etc.

[0063] As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the present disclosure. As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

[0064] Those skilled in the art will appreciate that the boundaries between the above-mentioned operations are merely illustrative. Multiple operations can be combined into a single operation, a single operation can be distributed among additional operations, and operations can be performed at least partially overlapping in time. Moreover, alternative embodiments can include multiple instances of a particular operation, and the order of operations can be changed in various other embodiments. However, other modifications, variations, and replacements are also possible. Aspects and elements of all embodiments disclosed above can be combined in any manner and / or in combination with aspects or elements of other embodiments to provide multiple additional embodiments. Therefore, this specification and the accompanying drawings should be considered illustrative, not restrictive.

[0065] Although some specific embodiments of the present disclosure have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the present disclosure. The various embodiments disclosed herein may be combined in any manner without departing from the spirit and scope of the present disclosure. It should also be understood by those skilled in the art that various modifications may be made to the embodiments without departing from the scope and spirit of the present disclosure. The scope of the present disclosure is defined by the appended claims.

Claims

1. An interventional device for implanting an electrode into the brain through a blood vessel, wherein the blood vessel has a vascular channel and a vascular wall, characterized in that: The blood vessels include main blood vessels and branch blood vessels, and the interventional device includes: a first guide member, wherein a distal end of the first guide member is movable distally in the vascular channel and establishes a first support point in the vascular channel, wherein the first support point is located in the main blood vessel; a second guide member, the distal end of which is capable of passing through the first guide member and moving distally in the vascular channel to establish a second support point in the vascular channel, such that the second guide member extends in an arc between the first support point and a second support point, the second support point being located in the branch vessel; and A puncture kit is used to carry an electrode, and the distal end of the puncture kit can pass through a first guide member, move distally in a blood vessel channel, and puncture the blood vessel wall in a target puncture area between a first support point and a second support point, thereby implanting the carried electrode into the brain, wherein the target puncture area is located in an angle area formed by a central axis of the first guide member and the second guide member, and the direction along which the blood vessel wall is punctured is adjusted based on the positions of the first support point and the second support point. The second guide and the puncture kit can be guided independently of each other in the first guide.

2. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 1, wherein: The first guide is configured as a supporting catheter, wherein a distal outer diameter of the supporting catheter is substantially equal to an inner diameter of the blood vessel at a first supporting point, so as to establish a first supporting point in the blood vessel channel.

3. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 2, wherein: The support catheter has a first working channel for the second guide and has a second working channel for the puncture kit.

4. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 2, wherein: The distal end of the support conduit has a lower material hardness than the proximal end of the support conduit.

5. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 2, wherein: The distal end of the supporting catheter is configured with a first visual marker.

6. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 1, wherein: The second guide member is configured as a stent assembly, which includes a guide wire, a guide catheter, and a support stent. The guide wire is used to guide the guide catheter, the guide catheter is used to guide the support stent, and the support stent is used to support the blood vessel wall.

7. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The distal end of the guide wire can be shaped.

8. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The guide wire gradually becomes thinner from the proximal end to the distal end.

9. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The guide wire is made of metal material.

10. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The guide catheter is sleeved on the guide wire and can move along the guide wire.

11. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The inner diameter of the guide catheter is configured to be greater than or equal to the outer diameter of the guide wire.

12. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The distal end of the guide catheter is configured with a second visualization marker.

13. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The proximal end of the guide catheter has a greater material hardness than the distal end of the guide catheter.

14. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The guide catheter is made of one or more of the following materials: acrylonitrile butadiene styrene (ABS), polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), polymethylpentene (PMP), polymethyl methacrylate (PMMA); polycarbonate (PC), polyphenylene oxide (PPO), modified phenylene oxide (modified PPO), polyphenylene ether (PPE); polyimide (PI), polybenzimidazole (PBI); polyphenylene sulfide (PPS), polyetheretherketone (PEEK); fluorinated ethylene-propylene (FEP), ethylene-chlorotrifluoroethylene (ECTFE), ethylene, ethylene-tetrafluoroethylene (ETFE), polychlorotrifluoroethylene (PCTFE), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), polyvinylidene fluoride (PVDF); elastomeric silicone polymer, polyether pre-segment amide or thermoplastic copolyether (PEBAX); metal.

15. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 6, wherein: The support stent is constructed as a self-expanding stent, which includes a first proximal pushing rod and a distal stent body. The first pushing rod is used to push the stent body through the guide catheter. After leaving the guide catheter, the stent body can rely on self-expansion force to radially open and support on the blood vessel wall.

16. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 15, characterized in that: The stent body of the self-expanding stent can be moved out of the guide catheter by withdrawing the guide catheter or by pushing the stent body distally with a first pushing rod.

17. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 15, wherein: The stent body of the self-expanding stent is made of memory alloy material.

18. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 15, wherein: A third development mark is configured on the stent body of the self-expanding stent.

19. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 15, wherein: The stent body of the self-expanding stent includes a plurality of closed-loop network units and a plurality of open-loop network units.

20. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 15, wherein: The outer diameter of the self-expanding stent in a compressed state is smaller than or equal to the inner diameter of the guide catheter.

21. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 1, wherein: The puncture kit includes: a puncture needle with a tip for puncture at the distal end and a hollow interior structure, a needle sheath sleeved over the puncture needle for protecting the tip of the puncture needle, and an electrode guide needle located in the cavity of the puncture needle, wherein the distal end of the electrode guide needle has a mating portion for carrying an electrode.

22. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 21, wherein: The matching portion of the electrode guide needle is configured as a tip, and the tip can pass through a hole configured in the electrode for matching with the electrode guide needle.

23. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 22, wherein: The tip has a stepped or tapered structure so that the tip can carry the electrode when it moves distally, and the electrode can fall off the tip when the tip is withdrawn proximally after being implanted in the brain.

24. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 21, wherein: The electrode guide needle is made of metal material.

25. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 1, wherein: The puncture kit is equipped with a puncture catheter for guiding the puncture kit to the target puncture area.

26. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 25, wherein: The puncture kit is equipped with an occluder for sealing the punctured blood vessel wall.

27. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 26, wherein: The occluder is constructed as a self-expanding occluder, which includes a proximal third pushing rod and a distal occluding structure. The third pushing rod is used to push the occluding structure through the puncture catheter. After leaving the puncture catheter, the occluding structure can rely on self-expansion force to radially open and adhere to the punctured blood vessel wall.

28. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 27, wherein: The occluding structure of the occluder is a flower-shaped, umbrella-shaped, disc-shaped, ring-shaped, cylindrical or funnel-shaped structure.

29. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 27, wherein: An electric release portion is configured at the distal end of the third pushing rod for causing the blocking structure to fall off from the third pushing rod when electricity is supplied.

30. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 1, wherein: The electrodes are flexible electrodes.

31. The interventional device for implanting an electrode into the brain through a blood vessel according to claim 1, characterized in that: The second guide member is supported on the blood vessel wall at the second support point, so that the blood vessel wall at the second support point is tightened.

32. An interventional device for implanting an electrode into the brain via a blood vessel, wherein the blood vessel comprises a first blood vessel segment and a second blood vessel segment extending in different directions, characterized in that: The interventional device comprises: a first guide member, wherein a distal end of the first guide member is movable distally within the vascular channel of the first blood vessel segment and reaches a first position in the first blood vessel segment and near a connection between the first blood vessel segment and the second blood vessel segment; a second guide member, the distal end of which is capable of moving distally in the first guide member and continuing to move distally after reaching the distal end of the first guide member, so as to pass through a connection between the first and second blood vessel segments and enter the second blood vessel segment, thereby reaching and being fixed at a second position; and A puncture kit is configured to carry an electrode, wherein the distal end of the puncture kit is capable of moving distally in a first guide and continuing to move distally after reaching the distal end of the first guide to puncture a blood vessel wall between a first position and a second position, thereby implanting the carried electrode into the brain. The region where the blood vessel wall is punctured is within an angle region formed by a central axis of the first guide and the second guide, and the direction along which the blood vessel wall is punctured is adjusted based on the first position and the second position. The second guide and the puncture kit can be guided independently of each other in the first guide.

33. An interventional device for implanting an electrode into the brain via a blood vessel, wherein: The blood vessel includes a first blood vessel segment and a second blood vessel segment that are connected and extend in different directions, wherein a connection between the first blood vessel segment and the second blood vessel segment is near the brain, and the interventional device includes: a first catheter, wherein a distal end of the first catheter is configured to be able to reach and float at a first position located in a first blood vessel segment, and an opening of the distal end of the first catheter is substantially oriented in a first direction, the first position being located near the junction, and the first direction being a direction in which the first blood vessel segment extends near the junction; A stent assembly, the stent assembly comprising a stent at a distal end and a stent pushing rod connected to the stent, the stent assembly being configured such that the stent can be advanced along a lumen of a first catheter to the distal end of the first catheter, pass through the junction, enter a second blood vessel segment, and be fixed at a second position in the second blood vessel segment, such that the stent pushing rod extends along a branching direction of the blood vessel between the first position and the second position, and such that an opening at the distal end of the first catheter is deflected in a second direction by the stent pushing rod, the second direction being a direction in which the second blood vessel segment extends near the junction; a third catheter, wherein the distal end of the third catheter is configured to be able to reach along the lumen of the first catheter and extend beyond the distal end of the first catheter to approach a puncture site on the blood vessel wall; and The puncture kit is used to carry the electrode, and the puncture kit is configured so that its distal end can approach the distal end of the third catheter along the lumen of the third catheter, wherein, The third catheter is further configured such that, after the distal end of the puncture kit approaches the distal end of the third catheter, the distal end of the third catheter can puncture the blood vessel wall at the puncture position and reach outside the blood vessel but not enter the brain, the puncture position being within an angle formed by the central axis of the first catheter and the stent pushing rod, and the direction along which the blood vessel wall is punctured is adjusted based on the first position and the second position. The puncture kit is further configured to, after the distal end of the third catheter reaches outside the blood vessel, continue to move along the lumen of the third catheter and pass through the distal end of the third catheter to enter the brain, thereby implanting the carried electrode into the brain. The stent assembly and the puncture kit can be guided independently of each other in the first catheter.

34. The interventional device of claim 33, further comprising: a guide wire, wherein the distal end of the guide wire is configured to be able to follow the lumen of the first catheter to the distal end of the first catheter, pass through the connection, enter the second blood vessel segment, and reach the vicinity of the second position before the stent is fixed at the second position; as well as The second catheter is configured to be able to be sleeved over the guide wire after the distal end of the guide wire reaches the vicinity of the second position and before the stent is fixed at the second position, and the distal end of the second catheter can reach at least the second position along the extension trajectory of the guide wire, wherein, The guide wire is further configured to be retracted along the lumen of the second catheter after the distal end of the second catheter reaches at least the second position so that the stent assembly can enter the second catheter. The stent assembly is further configured to be able to enter the second catheter and enable the stent to reach the second position along the lumen of the second catheter. The second catheter is further configured to be retracted after the stent reaches the second position so as to allow the stent to self-expand and thus be fixed in the second position.

35. The interventional device according to claim 33 or 34, further comprising: The occluder assembly includes a occluder structure located at the distal end for occluding the puncture hole on the blood vessel wall and an occluder push rod connected to the occluder structure, wherein: The puncture kit is further configured to be able to be withdrawn along the lumen of the third catheter after the electrode carried by the kit is implanted into the brain so that the occluder assembly can enter the third catheter. The occluder assembly is further configured such that the occluding structure can reach the distal end of the third catheter along the lumen of the third catheter, and after extending from the distal end of the third catheter, it opens and adheres to the blood vessel wall to occlude the puncture hole.

36. The interventional device according to claim 33 or 34, wherein: The outer diameter of the distal end of the first catheter is smaller than the inner diameter of the first blood vessel segment.

37. The interventional device according to claim 33 or 34, wherein: The first blood vessel segment is a main blood vessel, and the second blood vessel segment is a branch blood vessel extending from the main blood vessel.

38. An interventional device for implanting an electrode into the brain via a blood vessel, wherein: The blood vessel includes a first blood vessel segment and a second blood vessel segment that are connected and extend in different directions, wherein a connection between the first blood vessel segment and the second blood vessel segment is near the brain, and the interventional device includes: a first catheter, wherein a distal end of the first catheter is configured to reach and be located at a first position in a first blood vessel segment, the first position being located near the junction; a second catheter, wherein the distal end of the second catheter is configured to be able to follow the lumen of the first catheter to the distal end of the first catheter, pass through the junction to enter the second blood vessel segment, and reach a second position located in the second blood vessel segment, and the distal end of the second catheter is further configured to be able to be withdrawn from the second position to a specific position between the first position and the second position; a stent assembly, the stent assembly comprising a stent at a distal end and a stent pushing rod connected to the stent, the stent assembly being configured such that the stent can be moved along the lumen of the second catheter to the distal end of the second catheter after the distal end of the second catheter reaches the second position, and is fixed at the second position after passing the distal end of the second catheter, so that the stent pushing rod extends between the first position and the second position; and The puncture kit is used to carry the electrode. The puncture kit is configured so that its distal end can, after the distal end of the second catheter is withdrawn from the second position to the specific position, reach the distal end of the second catheter along the lumen of the second catheter and continue to move after passing the distal end of the second catheter, so as to puncture the blood vessel wall at the puncture position corresponding to the specific position and enter the brain, thereby implanting the carried electrode into the brain.

39. The interventional device of claim 38, further comprising: The guide wire is configured such that its distal end can reach the distal end of the first catheter along the lumen of the first catheter, pass through the connection, enter the second blood vessel segment, and reach the vicinity of the second position before the stent is fixed at the second position, wherein, The second catheter is further configured to be able to be sheathed over the guide wire before the stent is fixed at the second position, and the distal end of the second catheter can reach at least the second position along the extension trajectory of the guide wire. The guide wire is further configured to be retracted along the lumen of the second catheter after the distal end of the second catheter reaches at least the second position so that the stent assembly can enter the second catheter. The stent assembly is further configured to be able to enter the second catheter and enable the stent to reach the second position along the lumen of the second catheter. The second catheter is further configured to be withdrawn after the stent reaches the second position so as to allow the stent to self-expand and be fixed at the second position, and to enable the distal end of the second catheter to reach and be located at the specific position.

40. The interventional device according to claim 38 or 39, wherein There are one or more specific locations, so that the distal end of the puncture kit can puncture the blood vessel wall at one or more puncture locations corresponding to the one or more specific locations and enter the brain, thereby implanting the one or more electrodes carried by the kit into the brain.

41. The interventional device according to claim 38 or 39, further comprising: The occluder assembly includes a closure structure located at the distal end for occluding the puncture hole in the blood vessel wall and an occluder push rod connected to the closure structure. The occluder assembly is configured as follows: The blocking structure can move along the lumen of the second catheter to the distal end of the second catheter, and then continue to move after passing the distal end of the second catheter to reach the vicinity of the puncture site, and After at least part of the puncture kit is withdrawn into the blood vessel, the blocking structure can penetrate the blood vessel wall from the puncture hole at the puncture position, and after reaching outside the blood vessel, it opens and adheres to the blood vessel wall to block the puncture hole.

42. The interventional device according to claim 38 or 39, wherein The puncture kit includes: a puncture needle with a tip at the distal end for puncturing the blood vessel wall and a hollow interior structure, a needle sheath arranged outside the puncture needle for protecting the tip of the puncture needle to prevent the tip of the puncture needle from puncturing the second catheter, and an electrode guide needle located in the cavity of the puncture needle, wherein the distal end of the electrode guide needle has a mating portion structured to carry an electrode.

43. The interventional device according to claim 42, wherein The puncture kit is configured as follows: The distal end of the puncture needle, the distal end of the needle sheath and the distal end of the electrode guide needle can reach the distal end of the second catheter along the lumen of the second catheter; After passing the distal end of the second catheter, the distal end of the needle sheath can stop moving, while the distal ends of the puncture needle and the electrode guide needle can continue moving to extend from the needle sheath and approach the puncture site; The distal end of the puncture needle is capable of piercing the blood vessel wall at the puncture site and reaching outside the blood vessel but not entering the brain; The distal end of the puncture needle can stop moving after reaching outside the blood vessel, while the distal end of the electrode guide needle can continue moving in the cavity of the puncture needle and pass through the distal end of the puncture needle to enter the brain, thereby implanting the carried electrode into the brain.

44. The interventional device of claim 43, further comprising: The occluder assembly includes a occluder structure located at the distal end for occluding the puncture hole on the blood vessel wall and an occluder push rod connected to the occluder structure, wherein: The electrode guide needle is further configured to be able to be withdrawn along the cavity of the puncture needle after the electrode carried by the needle is implanted into the brain so that the occluder assembly can enter the cavity of the puncture needle. The occluder assembly is further configured such that the occluding structure can reach the distal end of the puncture needle along the cavity of the puncture needle, and after extending from the distal end of the puncture needle, it opens and adheres to the blood vessel wall to seal the puncture hole.

45. The interventional device according to claim 38 or 39, wherein The first blood vessel segment is a main blood vessel, and the second blood vessel segment is a branch blood vessel extending from the main blood vessel.

46. ​​An interventional device for implanting an electrode into the brain via a blood vessel, wherein: The blood vessel includes a first blood vessel segment and a second blood vessel segment that are connected and extend in different directions, wherein a connection between the first blood vessel segment and the second blood vessel segment is near the brain, and the interventional device includes: a first catheter, wherein a distal end of the first catheter is configured to be able to reach and float at a first position located in a first blood vessel segment, and an opening of the distal end of the first catheter is substantially oriented in a first direction, the first position being located near the junction, and the first direction being a direction in which the first blood vessel segment extends near the junction; a stent assembly, the stent assembly comprising a stent at a distal end and a stent pushing rod connected to the stent, the stent assembly being configured such that the stent can be advanced along a lumen of a first catheter to the distal end of the first catheter, pass through the junction, enter a second blood vessel segment, and be fixed at a second position in the second blood vessel segment, such that the stent pushing rod extends along a branching direction of the blood vessel between the first position and the second position, and such that an opening at the distal end of the first catheter is deflected in a second direction by the stent pushing rod, the second direction being a direction in which the second blood vessel segment extends near the junction; and An electrode guide needle, wherein the distal end of the electrode guide needle is constructed to carry an electrode, and the electrode guide needle is configured so that its distal end can reach and extend from the distal end of the first catheter along the lumen of the first catheter, penetrate the blood vessel wall at a puncture position on the blood vessel wall to enter the brain, thereby implanting the carried electrode into the brain, wherein the puncture position is within the angle region formed by the central axis of the first catheter and the stent pushing rod, and the insertion direction of the electrode guide needle is adjusted based on the first position and the second position. The support assembly and the electrode guide needle can be guided independently of each other in the first catheter.

47. The interventional device of claim 46, further comprising: a puncture needle having a tip and an internal cavity for puncturing a blood vessel wall, the puncture needle being configured to be sheathed over the electrode guide needle and having its distal end capable of extending along the lumen of the first catheter together with the distal end of the electrode guide needle to the distal end of the first catheter, and the distal end of the puncture needle being capable of puncturing the blood vessel wall at the puncture location and reaching outside the blood vessel without entering the brain, and The electrode guide needle is further configured to, after the distal end of the puncture needle reaches outside the blood vessel, continue to move along the inner cavity of the puncture needle and pass through the distal end of the puncture needle to enter the brain, thereby implanting the carried electrode into the brain.

48. The interventional device according to claim 47, wherein The puncture needle cover is provided with a needle sheath, and the needle sheath is configured to be sheathed outside the puncture needle to protect the tip of the puncture needle to prevent the tip of the puncture needle from puncturing the first catheter.

49. A medical device, characterized in that The medical device comprises an interventional apparatus for implanting an electrode into the brain through a blood vessel according to any one of claims 1 to 48.

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