An upwardly transmissible non-systemic pesticide nanogel suspending agent and a preparation method thereof

Abstract

The present application relates to a kind of non-systemic pesticide nanogel suspending agent capable of conducting upwards and its preparation method.The nanogel suspending agent is composed of pesticide microspheres and dispersant, compared with non-systemic pesticide microemulsion under the same concentration, can increase 6.9 times of the effect of conducting upwards, improve 30% of leaf surface enrichment concentration.In addition, the present application can be extended to the drug delivery system of a variety of non-systemic insecticide, fungicide, plant growth regulator, can be well realized non-systemic pesticide in the crop in vivo conducting upwards, provide new theory and technology for improving pesticide utilization rate.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of pesticide formulations, in particular to an upwardly transmissible non-systemic pesticide nanogel suspension and a preparation method thereof. BACKGROUND

[0002] Pesticides are widely used to control pests in agriculture, ensuring the increasing demand for food production with the growth of global population. According to the latest data, nearly 3 billion kilograms of pesticides are used worldwide every year to reduce the harm of pests and the resulting economic losses. However, during the application of pesticides, most of them cannot reach the target site due to inevitable drift, splash, roll, volatilization and degradation, which not only reduces the utilization rate of pesticides, but also causes serious environmental impact by leaving residues in the environment. It is reported that pollution of two or more active ingredients of pesticides will put about 64% of the global agricultural land at risk of pollution, and 31% of the land at high risk of pollution. Therefore, how to improve the delivery efficiency of pesticides and reduce the amount of pesticides has become a top priority in the field of agriculture.

[0003] Increasing the contact probability of pesticides and targets is an important strategy to improve the utilization rate of pesticides. Recently, soil application to control above-ground pests has gradually entered people's field of vision. Compared with foliar spraying, most of the main factors leading to pesticide loss, such as spray drift, splash, roll, volatilization, etc. can be avoided by soil application. In addition, pesticides can be applied in soil at a higher concentration, which facilitates the continuous absorption of crops, not only prolongs the persistence of pesticides, but also to a certain extent, can reduce the input of labor. At the same time, since the active ingredients are almost not diffused in the air, soil application can also reduce the impact of pesticides on beneficial organisms such as bees, spiders and ladybugs, and is more environmentally friendly.

[0004] In the process of soil application, the absorption and migration of pesticides in soil are crucial to the final control efficiency, which is usually affected by the physicochemical properties of active ingredients, plant species, soil water content and organic matter adsorption. Among them, the physicochemical properties of active ingredients are one of the prominent factors affecting soil application. Generally speaking, according to the different absorption and transmission behaviors of pesticides in plants, they can be divided into systemic pesticides and non-systemic pesticides. For systemic insecticides such as neonicotinoids, after contacting with plant roots, they can penetrate into the interior of plant roots and circulate to various parts of the plant. The uniform distribution in the plant body improves the contact probability of active ingredients with targets and reduces the waste of pesticides. However, for non-systemic pesticides, due to their high octanol-water partition coefficient and other reasons, they cannot be transmitted upwards after being absorbed by plant roots, resulting in that they cannot be applied in soil to control above-ground pests, which greatly limits the application of non-systemic pesticides. At present, people need to continuously develop new systemic pesticides to meet the needs of soil application and control. However, it is quite difficult to develop a new pesticide, which not only needs a lot of manpower and material resources, but also takes several years or even decades of time from synthesis to industrial production and formulation, which is a time-consuming and laborious process. SUMMARY

[0005] In view of the defects in the prior art, the purpose of the present application is to provide a non-systemic pesticide nanogel suspension capable of upward transmission, which can make non-systemic pesticides transmit upwards to various tissues of plants after being absorbed by roots, increase the retention of non-systemic pesticides in plants and prolong their effective period.

[0006] To achieve the above purpose, the technical scheme adopted by the present application is:

[0007] A non-systemic pesticide nanogel suspension capable of upward transmission, characterized in that it comprises pesticide microspheres and a dispersant; the pesticide microspheres are composed of a carrier and a pesticide active ingredient, and the dispersant is composed of a surfactant and water.

[0008] The pesticide active ingredient is 0.2-2.5% by weight, the carrier is 7.0-7.31% by weight, the surfactant is 28.0-29.3% by weight, and the rest is water.

[0009] On the basis of the above scheme,

[0010] The average particle size of the pesticide microspheres is 17-60 nm;

[0011] The pesticide active ingredient is one of the following formulations or a combination of several thereof;

[0012] Fungicides: including tebuconazole, chlorothalonil, pyrrolnitrin, pyraclostrobin, prochloraz;

[0013] Insecticides: including bifenthrin, metaflumizone, lambda-cyhalothrin, abamectin;

[0014] Herbicides: including chlorthal-dimethyl, pretilachlor, benzfuryl, flurichloralin.

[0015] On the basis of the above scheme,

[0016] The carrier is a random copolymer of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate.

[0017] Another object of the present application is to provide a preparation method of the non-systemic pesticide nanogel suspension capable of upward conduction.

[0018] To achieve the above object, the technical scheme adopted by the present application is:

[0019] The preparation method of the non-systemic pesticide nanogel suspension capable of upward conduction, characterized in that it comprises the following steps:

[0020] Step 1, dissolving the pesticide active ingredient in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate to form an oil phase solution;

[0021] Step 2, dissolving the initiator in water to form an aqueous phase solution;

[0022] Step 3, adding the above oil phase solution to the aqueous phase solution, and adding the surfactant dropwise until the system forms a microemulsion; after removing the oxygen in the microemulsion, heating to carry out the reaction to obtain the nanogel suspension.

[0023] On the basis of the above scheme,

[0024] In step 1, the proportion of each component in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate is: 32.5-33.8wt% octyl acrylate, 24.0wt% N-vinyl caprolactam and 42.2-43.5wt% methoxy polyethylene glycol acrylate; the pesticide active ingredient is 2.8-35.7wt% of the above mixture;

[0025] In step 2, the initiator is ammonium persulfate;

[0026] In step 3, the surfactant is a mixture of Tween 80 and n-butanol, and the mass ratio of Tween to n-butanol is 2:1;

[0027] In step 3, the reaction condition is 60℃ for 12h.

[0028] The non-systemic pesticide nanogel suspension agent capable of upward conduction and the preparation method thereof have the following beneficial effects:

[0029] 1. The preparation method provided by the application obtains a new type of suspension agent with extremely small and stable particle size and has a long sustained-release effect.

[0030] 2. The application can endow oil-soluble non-systemic pesticides such as lambda-cyhalothrin with upward conduction capacity, which is beneficial to expand the use mode of traditional pesticides, improve the utilization rate of pesticides, and save manpower and material resources.

[0031] 3. The application can prevent high-concentration active ingredients from causing root phytotoxicity, which is beneficial to protect the agricultural ecological environment and reduce the negative impact on food crops. BRIEF DESCRIPTION OF DRAWINGS

[0032] The application has the following drawings:

[0033] Figure 1 It is a nanogel morphology characterization diagram of lambda-cyhalothrin, which includes the appearance of the non-systemic pesticide nanogel suspension agent and the transmission electron microscope diagram of the nanogel.

[0034] Figure 2 It is a release curve diagram of lambda-cyhalothrin nanogel in a dispersion phase methanol: water = 4:6 solution.

[0035] Figure 3 It is a storage stability analysis diagram of lambda-cyhalothrin nanogel.

[0036] Figure 4 It is a change in the appearance of the vicia faba seedling root after the vicia faba seedling is cultured for 1, 3 and 5 days using lambda-cyhalothrin microemulsion and nanogel suspension agent dilution liquid.

[0037] Figure 5 It is a lambda-cyhalothrin residual concentration analysis diagram of the top leaf part after the vicia faba seedling is cultured for 1, 3 and 5 days using lambda-cyhalothrin microemulsion and nanogel suspension agent dilution liquid.

[0038] Figure 6 It is a lambda-cyhalothrin residual concentration analysis diagram of the root after the vicia faba seedling is cultured for 1, 3 and 5 days using lambda-cyhalothrin microemulsion and nanogel suspension agent dilution liquid.

[0039] Figure 7 It is a comparison of the calculation results of the lambda-cyhalothrin transport factor in the vicia faba seedling after the vicia faba seedling is cultured for 1, 3 and 5 days using lambda-cyhalothrin microemulsion and nanogel suspension agent dilution liquid, and the calculation method is the lambda-cyhalothrin residual concentration in the leaf divided by the lambda-cyhalothrin residual concentration in the root. DETAILED DESCRIPTION

[0040] The application will be further described in detail below with reference to the accompanying drawings.

[0041] The application will be further described in detail below with reference to the accompanying drawings.

[0042] Example 1 2.5% lambda-cyhalothrin nanogel suspension

[0043]

[0044]

[0045] In the above formula, the proportions of the components in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate are: 33 wt% octyl acrylate, 24.0 wt% N-vinyl caprolactam and 42.9 wt% methoxy polyethylene glycol acrylate; the pesticide active ingredient is 35.7 wt% of the above mixture.

[0046] The 2.5% lambda-cyhalothrin nanogel suspension is prepared according to the above formula, and the preparation steps are as follows:

[0047] a. 0.625 g of lambda-cyhalothrin is ultrasonically dissolved in a mixed solvent of 0.58 g of octyl acrylate, 0.42 g of N-vinyl caprolactam and 0.75 g of methoxy polyethylene glycol acrylate to form an oil phase solution.

[0048] b. 0.021 g of ammonium persulfate is dissolved in 15 g of water to form an aqueous phase solution.

[0049] c. The aqueous phase solution obtained in step b is added to the oil phase solution obtained in step a, and the surfactant is added dropwise under stirring until a microemulsion is formed; nitrogen gas is passed through the obtained microemulsion for 10 minutes to remove oxygen in the system, and then the reaction is continued for 12 h at 60°C under continuous stirring.

[0050] d. The solution obtained in step c is cooled to room temperature to obtain a light yellow transparent 2.5% lambda-cyhalothrin nanogel suspension.

[0051] In the above lambda-cyhalothrin nanogel suspension, the lambda-cyhalothrin is 2.5 wt%, the carrier is 7.0 wt%, and the surfactant is 28.0 wt%.

[0052] The final obtained nanogel suspension is characterized in terms of morphology, release performance, storage stability and upward transmission ability,

[0053] Figure 1 Figure 1 is a morphology characterization chart of lambda-cyhalothrin nanogel, including appearance of the nanogel suspension and its transmission electron microscope characterization chart, the scale is 200 nm.

[0054] First, we observed the appearance of the obtained lambda-cyhalothrin nanogel suspension and characterized it by transmission electron microscope, and the results are shown in Figure 1. Figure 1 As the particle size of the nanomicrosphere therein is extremely small, the suspension is in a transparent state, and the average particle size of the nanomicrosphere is 17 nm.

[0055] Figure 2 Figure 2 is a release curve chart of lambda-cyhalothrin nanogel in a methanol: water = 4:6 solution in the dispersed phase. After characterization of the release performance of the lambda-cyhalothrin nanogel suspension, we found that 41.2% was released in the first 96 hours, and the rest was slowly released in the subsequent process. This is due to the fact that the nanogel slows down the diffusion of lambda-cyhalothrin. Because of the higher concentration difference, the release speed of lambda-cyhalothrin is faster in the initial stage, while after 96 h, the concentration difference is basically flat, and the overall release rate decreases significantly.

[0056] Figure 3 Figure 3 is an analysis chart of the storage stability of the lambda-cyhalothrin nanogel suspension. In order to test the storage stability of the nanogel preparation, the nanogel suspension was packaged in an ampoule, and stored at 0±2, 25±2 and 54±2℃ respectively for 14 days. The particle size and distribution of the sample were tested every 2 days. As shown in Figure 3, under cold storage, normal temperature and hot storage, the particle size of the nanogel did not change significantly with time, the average particle size fluctuated between 16-21 nm, and the PDI value was less than 0.22, indicating that the nanogel has good storage stability. Figure 3

[0057] Figure 4 Figure 4 shows the changes in the appearance of the root of the Vicia faba seedlings after 1, 3 and 5 days of culture with lambda-cyhalothrin microemulsion and nanogel suspension dilutions. The average particle size of the lambda-cyhalothrin microemulsion used is 17 nm. As shown in the figure, after 1, 3 and 5 days of culture in the lambda-cyhalothrin microemulsion dilution, the roots of the Vicia faba seedlings gradually turned black and the growth became weak; while after 1, 3 and 5 days of culture in the lambda-cyhalothrin nanogel suspension dilution, the roots of the Vicia faba seedlings remained healthy, indicating that the lambda-cyhalothrin nanogel can avoid the phytotoxicity caused by the large accumulation of lambda-cyhalothrin in the roots.

[0058] Figure 5 Figure 5 shows the residual concentration of lambda-cyhalothrin in the top leaf part after 1, 3 and 5 days of culture with lambda-cyhalothrin microemulsion and nanogel suspension dilutions.

[0059] ​Figure 6 Residual concentration of lambda-cyhalothrin in roots after 1, 3, 5 days of culturing Vicia faba seedlings with lambda-cyhalothrin microemulsion and nanogel suspension concentrate dilutions.

[0060] Figure 7 Comparison of calculated results of lambda-cyhalothrin transport factor in Vicia faba seedlings after 1, 3, 5 days of culturing Vicia faba seedlings with lambda-cyhalothrin microemulsion and nanogel suspension concentrate dilutions, calculated by dividing the concentration of lambda-cyhalothrin in leaves by the concentration of lambda-cyhalothrin in roots.

[0061] It can be found through detection that lambda-cyhalothrin in the microemulsion treatment group is strongly absorbed by the roots, and the concentration of lambda-cyhalothrin in the roots reached 452.8 mg / L on the 5th day, while the concentration of lambda-cyhalothrin in the leaf part was only 35.2 mg / L, and the transport factor was only 0.08, indicating that the uncoated lambda-cyhalothrin has very poor upward transmission ability, and once high-concentration is applied, it will damage the roots of crops and cause phytotoxicity. In comparison with the nanogel suspension concentrate treatment group, the concentration of lambda-cyhalothrin in the roots was maintained at about 70 mg / L, the concentration in the leaf part was maintained at about 46 mg / L, and the transport factor increased to 0.63, indicating that the lambda-cyhalothrin coated by the nanogel has the ability to transmit upward, and can avoid damage to the roots of crops caused by high-concentration liquid.

[0062] Example 2 Pyraclostrobin nanogel suspension concentrate 2.5%

[0063]

[0064] In the above formula, the proportions of the components in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate are: 33 wt% octyl acrylate, 24.0 wt% N-vinyl caprolactam and 42.9 wt% methoxy polyethylene glycol acrylate; the active ingredient of the pesticide is 35.7 wt% of the above mixture.

[0065] The pyraclostrobin nanogel suspension concentrate 2.5% is prepared according to the above formula. The preparation steps are as follows:

[0066] a. Dissolve 0.625 g of pyraclostrobin in a mixed solvent of 0.58 g of octyl acrylate, 0.42 g of N-vinyl caprolactam and 0.75 g of methoxy polyethylene glycol acrylate to form an oil phase solution.

[0067] b. Dissolve 0.021 g of ammonium persulfate in 15.6 g of water to form an aqueous phase solution.

[0068] c. To the oil phase solution obtained in step a, the water phase solution obtained in step b was added, and the surfactant was added dropwise under stirring until the system formed a microemulsion; the obtained microemulsion was protected by nitrogen for 10 min to remove the oxygen in the system, and then the reaction was continued at 60°C for 12 h under continuous stirring.

[0069] d. The solution obtained in step c was cooled to room temperature, and a light yellow transparent 2.5% pyraclostrobin nanogel suspension was obtained.

[0070] In the above pyraclostrobin nanogel suspension, the pyraclostrobin was 2.5 wt%, the carrier was 7.0 wt%, and the surfactant was 28.0 wt%. The average particle size of the nanomicrosphere in the obtained pyraclostrobin nanogel suspension was 56 nm.

[0071] The upward transmission ability of the obtained pyraclostrobin nanogel suspension was compared with that of pyraclostrobin suspension, and the average particle size of the pyraclostrobin suspension used was 800 nm. The results are as follows:

[0072] Table 2. Statistical analysis of the upward transmission results of 2.5% pyraclostrobin nanogel suspension

[0073]

[0074] Example 3 0.2% abamectin nanogel suspension

[0075]

[0076]

[0077] In the above formula, the proportions of the components in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate are: 32.5 wt% octyl acrylate, 24.0 wt% N-vinyl caprolactam and 43.5 wt% methoxy polyethylene glycol acrylate; the pesticide active ingredient is 2.8 wt% of the above mixture.

[0078] The 0.2% abamectin nanogel suspension was prepared according to the above formula. The preparation steps are as follows:

[0079] a. 0.049 g of abamectin was ultrasonically dissolved in a mixed solvent of 0.57 g of octyl acrylate, 0.42 g of N-vinyl caprolactam and 0.76 g of methoxy polyethylene glycol acrylate to form an oil phase solution.

[0080] b. 0.024 g of ammonium persulfate was dissolved in 15.1 g of water to form a water phase solution.

[0081] c. To the oil phase solution obtained in step a, the water phase solution obtained in step b was added, and the surfactant was added dropwise under stirring until the system formed a microemulsion; the resulting microemulsion was protected by nitrogen for 10 min to remove the oxygen in the system, and then the reaction was continued at 60°C for 12 h under continuous stirring.

[0082] d. The solution obtained in step c was cooled to room temperature to obtain a light yellow transparent 2.5% abamectin nanogel suspension.

[0083] In the above abamectin nanogel suspension, the abamectin is 0.2% by weight, the carrier is 7.31% by weight, and the surfactant is 29.3% by weight. The average particle size of the nanomicrosphere in the obtained abamectin nanogel suspension is 58 nm.

[0084] The upward transmission capacity of the obtained abamectin nanogel suspension and abamectin microcapsule suspension was compared, and the average particle size of the microcapsule in the abamectin microcapsule suspension used was 416 nm. The results are as follows:

[0085] Table 3. Statistical analysis of the upward transmission results of 0.2% abamectin nanogel suspension

[0086]

[0087] Example 4 1.8% prochloraz nanogel suspension

[0088]

[0089] In the above formula, the proportions of the components in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate are: 33.8% by weight of octyl acrylate, 24.0% by weight of N-vinyl caprolactam and 42.2% by weight of methoxy polyethylene glycol acrylate; the pesticide active ingredient is 25.4% by weight of the above mixture.

[0090] According to the above formula, 1.8% prochloraz nanogel suspension was prepared. The preparation steps are as follows:

[0091] a. 0.421 g of prochloraz was ultrasonically dissolved in a mixed solvent of 0.56 g of octyl acrylate, 0.4 g of N-vinyl caprolactam and 0.7 g of methoxy polyethylene glycol acrylate to form an oil phase solution.

[0092] b. 0.022 g of ammonium persulfate was dissolved in 14.2 g of water to form a water phase solution.

[0093] c. To the oil phase solution obtained in step a, the water phase solution obtained in step b was added, and the surfactant was added dropwise under stirring until the system formed a microemulsion; the obtained microemulsion was protected by nitrogen for 10 min to remove the oxygen in the system, and then the reaction was continued at 60°C for 12 h under continuous stirring.

[0094] d. The solution obtained in step c was cooled to room temperature to obtain a light yellow transparent 1.8% propanil nanogel suspension.

[0095] In the above propanil nanogel suspension, the propanil is 1.8% by weight, the carrier is 7.23% by weight, and the surfactant is 29.0% by weight. The average particle size of the nanomicrosphere in the obtained propanil nanogel suspension is 32 nm.

[0096] The upward transmission capacity of the obtained propanil nanogel suspension and propanil suspension was compared, and the average particle size of the propanil suspension used was 632 nm, and the results were as follows:

[0097] Table 4. Statistical analysis of the upward transmission results of 1.8% propanil nanogel suspension

[0098]

[0099] The upward transmission experiment results of each comparative material in Examples 2-4 show that when the average particle size of the microparticle exceeds the nanomaterial size range (100 nm), the upward transmission capacity will be greatly reduced.

[0100] Example 5 2.5% abamectin · lambda-cyhalothrin nanogel suspension

[0101]

[0102]

[0103] In the above formula, the ratio of each component in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate is: 33% by weight of octyl acrylate, 24.0% by weight of N-vinyl caprolactam and 42.9% by weight of methoxy polyethylene glycol acrylate; the pesticide active ingredient is 35.7% by weight of the above mixture.

[0104] According to the above formula, 2.5% abamectin · lambda-cyhalothrin nanogel suspension was prepared, and the preparation steps were as follows:

[0105] a. 0.31 g of lambda-cyhalothrin and 0.31 g of abamectin were dissolved in 0.58 g of octyl acrylate, 0.42 g of N-vinyl caprolactam and 0.75 g of methoxy polyethylene glycol acrylate to form an oil phase solution.

[0106] b. 0.021 g of ammonium persulfate was dissolved in 15.6 g of water to form an aqueous phase solution.

[0107] c. The aqueous phase solution obtained in step b was added to the oil phase solution obtained in step a, and the surfactant was added dropwise under stirring until the system formed a microemulsion; the obtained microemulsion was protected by nitrogen for 10 min to remove oxygen in the system, and then the reaction was continued at 60 °C for 12 h under continuous stirring.

[0108] d. The solution obtained in step c was cooled to room temperature to obtain a light yellow transparent 2.5% abamectin·lambda-cyhalothrin nanogel suspension.

[0109] In the above abamectin·lambda-cyhalothrin nanogel suspension, the abamectin is 1.25 wt%, the lambda-cyhalothrin is 1.25 wt%, the carrier is 7.06 wt%, and the surfactant is 28.2 wt%. The average particle size of the nanomicrosphere in the obtained abamectin·lambda-cyhalothrin nanogel suspension is 60 nm.

[0110] The upward transmission ability of the obtained abamectin·lambda-cyhalothrin nanogel suspension was compared with that of abamectin·lambda-cyhalothrin microemulsion, and the average particle size of the abamectin·lambda-cyhalothrin microemulsion was 38 nm. The results are as follows:

[0111] Table 5. 2.5% abamectin·lambda-cyhalothrin nanogel suspension

[0112]

[0113] The above Table 5 shows that if the active ingredient is not coated by the carrier material, but is free in the oil phase solvent in a dissolved state, even if the average particle size is smaller than the average particle size of the nanomicrosphere in the nanogel suspension, the systemic effect is poorer.

[0114] Example 6 2.5% lambda-cyhalothrin nanogel suspension

[0115]

[0116] In the above formulation, the ratio of each component in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate is: 33 wt% octyl acrylate, 24.0 wt% N-vinyl caprolactam and 42.9 wt% methoxy polyethylene glycol acrylate; the pesticide active ingredient is 35.7 wt% of the above mixture.

[0117] According to the above formulation, 2.5% lambda-cyhalothrin nanogel suspension is prepared, and the preparation steps are as follows:

[0118] a. Dissolve 0.62 g of lambda-cyhalothrin in a mixed solvent of 0.58 g of octyl acrylate, 0.42 g of N-vinyl caprolactam and 0.75 g of methoxy polyethylene glycol acrylate to form an oil phase solution.

[0119] b. Dissolve 0.021 g of ammonium persulfate in 15.6 g of water to form an aqueous phase solution.

[0120] c. Add the aqueous phase solution obtained in step b to the oil phase solution obtained in step a, and add the surfactant dropwise under stirring until the system forms a microemulsion; pass nitrogen through the obtained microemulsion for 10 min to remove oxygen in the system, and then continue to react for 12 h at 60°C under continuous stirring.

[0121] d. Cool the solution obtained in step c to room temperature to obtain a turbid yellow 2.5% lambda-cyhalothrin nanogel suspension.

[0122] In the above lambda-cyhalothrin nanogel suspension, the lambda-cyhalothrin is 2.5 wt%, the carrier is 7.06 wt% and the surfactant is 16.1 wt% by weight. The average particle size of the nanoscale microspheres in the obtained lambda-cyhalothrin nanogel suspension is 960 nm.

[0123] Example 7 2.5% abamectin nanogel suspension

[0124]

[0125] In the above formulation, the ratio of each component in the mixture of octyl acrylate, N-vinyl caprolactam and methoxy polyethylene glycol acrylate is: 28.1 wt% octyl acrylate, 23.7 wt% N-vinyl caprolactam and 48.2 wt% methoxy polyethylene glycol acrylate; the pesticide active ingredient is 45.9 wt% of the above mixture.

[0126] According to the above formulation, 2.5% abamectin nanogel suspension is prepared. The preparation steps are as follows:

[0127] a. 0.62 g of abamectin was dissolved in 0.38 g of octyl acrylate, 0.32 g of N-vinyl caprolactam and 0.65 g of methoxy polyethylene glycol acrylate to form an oil phase solution.

[0128] b. 0.024 g of ammonium persulfate was dissolved in 15.5 g of water to form an aqueous phase solution.

[0129] c. The aqueous phase solution obtained in step b was added to the oil phase solution obtained in step a, and the surfactant was added dropwise under stirring until the system formed a microemulsion; the obtained microemulsion was protected by nitrogen for 10 min to remove the oxygen in the system, and then the reaction was continued at 60°C for 12 h under continuous stirring.

[0130] d. The solution obtained in step c was cooled to room temperature to obtain a yellowish turbid 2.5% abamectin nanogel suspension with a large amount of precipitated particles at the bottom.

[0131] In the above abamectin nanogel suspension, the abamectin was 2.5 wt%, the carrier was 5.51 wt%, and the surfactant was 28.6 wt%. The average particle size of the precipitated particles in the obtained abamectin nanogel suspension was 2.41 μm, which was beyond the nanometer level and could not be suspended in water.

[0132] The experimental results of the modified raw material ratio in Examples 6-7 show that when the fixed raw material ratio is exceeded, the nanomicrosphere in the target particle size range cannot be obtained.

[0133] The pesticide active ingredients in the above Examples 1-5 can be replaced by various non-systemic insecticides, fungicides and herbicides with high oil-water partition coefficient and difficult to dissolve in water, or a combination of any two or more of these formulations. The above formulations include: tebuconazole, chlorothalonil, pyrrolnitrin, pyraclostrobin, prochloraz (fungicide); bifenthrin, metaflumizone, lambda cyhalothrin, abamectin (insecticide); chlorthiamid, propachlor, fomesafen, fluoroglycofen (herbicide), etc.

[0134] The various embodiments provided by the present application can be combined with each other in any manner as needed, and the technical solutions obtained by such combination are also within the scope of the present application. Obviously, those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application also includes these modifications and variations.

[0135] The contents not described in detail in the specification belong to the prior art known to those skilled in the art.

Claims

1. A non-systemic pesticide nanogel suspension capable of upward conduction, characterized in that, This includes pesticide microspheres and dispersants; pesticide microspheres consist of a carrier and pesticide active ingredients, while dispersants consist of surfactants and water. The active ingredient of the pesticide is 0.2-2.5% by weight, the carrier is 7.0-7.31% by weight, the surfactant is 28.0-29.3% by weight, and the remainder is water; The average particle size of the pesticide microspheres is 17-60 nm; The active ingredient of the pesticide is one or a combination of several of the following formulations; Fungicides include tebuconazole, chlorothalonil, pyrrolizamide, pyraclostrobin, and prochloraz. Insecticides: including bifenthrin, cyhalofop-p-ethyl, lambda-cyhalothrin, and abamectin; Herbicides: including chlorpyrifos, pretilachlor, flumetsulam, and ethoxysulfuron; The carrier is a random copolymer of octyl acrylate, N-vinylcaprolactam, and methoxy polyethylene glycol acrylate, wherein the proportions of each component in the random copolymer are: 32.5-33.8 wt% octyl acrylate, 24.0 wt% N-vinylcaprolactam, and 42.2-43.5 wt% methoxy polyethylene glycol acrylate.

2. A method for preparing an upwardly conductive, non-systemic pesticide nanogel suspension as described in claim 1, characterized in that, Includes the following steps: Step 1: Dissolve the active pesticide ingredient in a mixture of octyl acrylate, N-vinylcaprolactam and methoxy polyethylene glycol acrylate to form an oil phase solution; Step 2: Dissolve the initiator in water to form an aqueous solution; Step 3: Add the above oil phase solution to the aqueous phase solution, and add surfactant dropwise until a microemulsion is formed in the system; remove oxygen from the microemulsion and then heat to react, to obtain a nanogel suspension.

3. The method for preparing the upwardly conductive non-systemic pesticide nanogel suspension as described in claim 2, characterized in that: The proportions of each component in the mixture of octyl acrylate, N-vinylcaprolactam, and methoxy polyethylene glycol acrylate described in step 1 are: 32.5-33.8 wt% octyl acrylate, 24.0 wt% N-vinylcaprolactam, and 42.2-43.5 wt% methoxy polyethylene glycol acrylate; the active pesticide ingredient is 2.8-35.7 wt% of the above mixture. The initiator mentioned in step 2 is ammonium persulfate; The surfactant mentioned in step 3 is a mixture of Tween 80 and n-butanol, with a mass ratio of Tween to n-butanol of 2:1; The reaction conditions described in step 3 are: reaction at 60°C for 12 hours.

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