Reagent bottles, reagent kits, cleaning systems and cleaning methods

Abstract

This invention relates to the field of medical device technology, and particularly to a reagent bottle, reagent kit, cleaning system, and cleaning method. A first sealing plate is provided inside the bottle, dividing the bottle's interior into a receiving space for holding reagents and a cleaning space located above the receiving space. A first through hole is formed on the first sealing plate, connecting the receiving space and the cleaning space. An opening communicating with the cleaning space is formed at the top of the bottle. A suction tube is installed in the receiving space, with its top communicating with the first through hole and its bottom extending downwards and communicating with the receiving space. A first sealing cap is then used to cover and seal the opening, allowing a reagent needle to pass sequentially through the first sealing cap, the cleaning space, and the first through hole before being engaged in the suction tube to draw reagents stored in the receiving space. This avoids contamination of the outer wall of the reagent needle by the reagent, reduces cleaning time, improves cleaning efficiency, and ensures the accuracy of test results.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a reagent bottle, reagent kit, cleaning system, and cleaning method. Background Technology

[0002] In gene sequencing equipment, reagents of different components need to be pumped into the biochip via an external power pump to carry out a reaction at a specific time. During this process, the reagent bottle or kit needs to be kept at a certain temperature to maintain the biological activity of the reagent components inside.

[0003] After sequencing is completed, the pumping system is cleaned to avoid cross-contamination.

[0004] A pumping system typically consists of a reagent needle, tubing, a selector valve, a power source, and a motion mechanism. Most current mainstream pumping systems insert the reagent needle directly into the reagent vial or the bottom of the kit, keeping it stationary throughout the sequencing process. Thorough cleaning of the pumping system is crucial; inadequate cleaning can lead to abnormal test results.

[0005] In existing technologies, there are three main categories of cleaning solutions after testing:

[0006] First, after sequencing is complete, manually place the cleaning reagent bottle or kit into the instrument for automatic cleaning.

[0007] Secondly, after sequencing is completed, the instrument automatically cleans the reagent needles using a specific cleaning module, without the need for manual intervention;

[0008] Third, by reducing the contact between the reagent needle and the reagent, the residual amount is controlled. Instead of cleaning the reagent needle immediately after sequencing, the user manually performs the cleaning process every once in a while.

[0009] The first approach thoroughly cleans both the inner and outer walls of the reagent needle, but requires the operator to manually change the cleaning kit multiple times, making the process cumbersome and time-consuming. The second approach avoids the tedious manual kit changes, but the need for a specific cleaning module increases system complexity and instrument costs. The third approach also requires users to manually perform the cleaning process periodically, only reducing the frequency. While this approach reduces the contact area, it still cannot completely eliminate a small amount of residual reagent. Although problems may not be immediately apparent, over time, additional cleaning is necessary; otherwise, unpredictable results such as decreased sequencing quality may occur.

[0010] Therefore, it can be seen that the commonly used cleaning methods for pumping systems and reagent kits in the existing technology have the drawbacks of time-consuming cleaning, incomplete cleaning, and reagent residues that affect the accuracy of test results. Summary of the Invention

[0011] The main objective of this invention is to provide a reagent bottle that addresses the technical problems in related technologies, such as time-consuming cleaning, incomplete cleaning leaving reagent residues that affect the accuracy of test results.

[0012] To achieve the above objectives, in a first aspect, the present invention provides a reagent bottle comprising:

[0013] The bottle body has a first sealing plate inside, which divides the inner cavity of the bottle body into a receiving space for containing reagents and a cleaning space located above the receiving space. A first through hole is formed on the first sealing plate to connect the receiving space and the cleaning space. An opening is formed on the top of the bottle body to connect with the cleaning space.

[0014] A suction tube, wherein the suction tube is installed within the receiving space, the top of the suction tube communicating with the first through hole, and the bottom of the suction tube extending downward and communicating with the receiving space; and,

[0015] A first sealing cap, which closes and seals the opening;

[0016] The reagent needle tip can pass sequentially through the first sealing cap, the cleaning space, and the first through hole before being engaged in the suction tube to draw up the reagent stored in the storage space; or,

[0017] The reagent needle can discharge cleaning fluid into the cleaning space when its tip retracts from the suction tube into the cleaning space, so as to clean the reagent needle.

[0018] Optionally, the aspirator includes a cleaning section, a flow guiding section, and a snap-fit ​​section arranged sequentially from top to bottom. The top of the cleaning section is connected to the first through hole, the snap-fit ​​section can snap and seal with the needle tip of the reagent needle, and the bottom of the snap-fit ​​section is connected to the receiving space and close to the inner bottom wall of the reagent bottle.

[0019] Optionally, the inner diameter of the cleaning section is larger than the inner diameter of the snap-fit ​​section, and the inner diameter of the guide section gradually decreases from top to bottom.

[0020] Optionally, the cleaning section is further provided with a flexible seal, which is located close to the flow guiding section. The reagent needle passes sequentially through the first sealing cap, the cleaning space, the first through hole, and the flexible seal, and then engages with the engaging section to draw reagent stored in the storage space through the engaging section; or...

[0021] The reagent needle can discharge cleaning fluid into the cleaning space when its tip passes through the snap-fit ​​section, the guide section, and the flexible seal and retracts into the cleaning section, so as to clean the reagent needle.

[0022] Optionally, the first sealing plate is further provided with a second through hole spaced apart from the first through hole. The second through hole connects the receiving space and the cleaning space. When the reagent needle is retracted into the cleaning section after passing through the snap-fit ​​section, the flow guide section and the flexible seal, the cleaning section, the cleaning space, the second through hole and the receiving space form a cleaning flow path for the cleaning fluid to flow.

[0023] Optionally, the first sealing plate is inclined, and the second through hole is formed at the lower part of the first sealing plate.

[0024] Optionally, the second through hole is also used for inserting an air vent needle to vent air into the receiving space through the air vent needle.

[0025] Optionally, the reagent bottle further includes a second sealing plate, which is stacked on top of the first sealing plate. The second sealing plate has an insertion hole for inserting the reagent needle at the position opposite to the first through hole. When the reagent needle is inserted into the cleaning section through the insertion hole, a gap is formed between the outer wall of the reagent needle and the edge of the insertion hole to connect the cleaning section with the cleaning space and allow the cleaning liquid to flow.

[0026] Optionally, the reagent bottle further includes a second sealing cap, which forms the bottom wall of the bottle body, and the inner bottom wall of the second sealing cap has a liquid collection groove formed at the position corresponding to the snap-fit ​​section.

[0027] Based on the same technical concept, in a second aspect, the present invention also proposes a reagent kit having a placement space therein, in which a variety of reagent bottles as described in the first aspect are inserted side by side, and the tops of all the reagent bottles extend upward and are exposed outside the reagent kit.

[0028] Based on the same technical concept, in a third aspect, the present invention also proposes a reagent kit having a plurality of reagent bottles as described in the first aspect, the tops of all the reagent bottles extending upwards outside the reagent kit.

[0029] Optionally, the outer wall of the reagent kit is provided with an observation window.

[0030] Based on the same technical concept, in a fourth aspect, the present invention also proposes a cleaning system, comprising:

[0031] The reagent bottle as described in the first aspect;

[0032] reagent needles; and,

[0033] A power pump is connected to the reagent needle, and the power pump is connected to a storage tank for storing cleaning solution and / or a gas source through two pipelines, so that the power pump can pump cleaning solution and / or gas into the reagent needle.

[0034] Optionally,

[0035] The cleaning system also includes a lifting mechanism, on which the reagent needle is mounted. The lifting drive mechanism can drive the reagent needle to move downward and pass through the first sealing cap, the cleaning space, and the first through hole in sequence before engaging in the suction tube; or drive the reagent needle to move upward to retract from the suction tube into the cleaning space.

[0036] or,

[0037] The cleaning system also includes a lifting mechanism, on which the reagent needle is mounted. The lifting mechanism can drive the reagent kit to move upward so that the reagent needle passes through the first sealing cap, the cleaning space and the first through hole in sequence and is then engaged in the aspiration tube.

[0038] Alternatively, the reagent kit can be driven downwards to retract the reagent needle from the aspirator into the cleaning space.

[0039] Optionally, the cleaning system further includes an exhaust needle that can penetrate the receiving space and / or the cleaning space, communicating the receiving space and / or the cleaning space with the outside of the reagent bottle.

[0040] Based on the same technical concept, in a fifth aspect, the present invention also proposes a cleaning method that uses the cleaning system described in the third aspect;

[0041] The cleaning method includes the following steps:

[0042] After the reagent needle has been inserted into the reagent tube and the reagent has been drawn, the needle tip is retracted into the cleaning space.

[0043] The cleaning solution is pumped into the reagent needle using the power pump to clean the reagent needle within the cleaning space.

[0044] Optionally, after the step of pumping cleaning fluid into the reagent needle using the power pump to complete the cleaning of the reagent needle within the cleaning space, the method further includes:

[0045] Air is pumped into the reagent needle using the power pump to dry the reagent needle within the cleaning space.

[0046] The present invention has the following beneficial effects:

[0047] This invention comprises a bottle body, a suction tube, and a first sealing cap. A first sealing plate is installed inside the bottle body, dividing the inner cavity of the bottle body into a reagent-containing space and a cleaning space above the reagent-containing space. A first through-hole is formed on the first sealing plate, connecting the reagent-containing space and the cleaning space. An opening communicating with the cleaning space is formed at the top of the bottle body. This allows the invention to complete cleaning within the cleaning space during use, eliminating the need to clean the reagent-containing space separately and preventing contamination of the cleaning space by the reagent in the reagent-containing space. The suction tube is then installed within the reagent-containing space, with its top communicating with the first through-hole and its bottom extending downwards and communicating with the reagent-containing space. This allows the reagent placed in the reagent-containing space to be suctioned out during use, further preventing contamination of the cleaning space by the reagent. Finally, the first sealing cap is used to close and seal the bottle. The device has an opening, allowing the reagent needle to pass sequentially through the first sealing cap, the cleaning space, and the first through hole before being engaged in the suction tube to draw up the reagent stored in the storage space. Furthermore, during use, the reagent needle can be used to draw the reagent out of the suction tube. Because the reagent needle is engaged in the suction tube, the contact area between the needle and the reagent is reduced, preventing contamination of the outer wall of the needle. This allows the needle to directly discharge cleaning fluid into the cleaning space as its tip retracts from the suction tube, cleaning both the outer and inner walls of the needle. This reduces cleaning time and effectively improves cleaning efficiency. Since the cleaning process is completed within the cleaning space, the amount of cleaning fluid used is reduced, thus preventing contamination of the needle by residual time within the storage space, resulting in more thorough cleaning and ensuring the accuracy of the test results. Attached Figure Description

[0048] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0049] Figure 1 This is a schematic diagram of the side structure of a reagent bottle as an example of the present invention;

[0050] Figure 2 for Figure 1 A schematic diagram of the disassembled state of the reagent bottle in the example;

[0051] Figure 3 This is a schematic diagram of the structure of the kit as an example of the present invention;

[0052] Figure 4 for Figure 3 A schematic diagram of another embodiment of the kit shown in the example;

[0053] Figure 5 for Figure 3 A side view of the sample kit;

[0054] Figure 6 This is a flowchart illustrating the cleaning method of the present invention;

[0055] Figure 7 This is a schematic diagram of the structure during liquid aspiration according to the present invention;

[0056] Figure 8 This is a schematic diagram showing the flow direction of the cleaning fluid during the cleaning process according to the present invention.

[0057] Explanation of reference numerals in the attached figures:

[0058]

[0059] The objectives, features, and advantages of this invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0060] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0061] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative positional relationship and movement of the mechanisms in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indication will also change accordingly.

[0062] In this invention, unless otherwise explicitly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "fixed" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0063] Furthermore, if the embodiments of this invention involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the meaning of "and / or" throughout the text includes three parallel solutions; for example, "A and / or B" includes solution A, solution B, or a solution where both A and B are satisfied simultaneously. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0064] The inventive concept of the present invention will be further explained below with reference to some specific embodiments.

[0065] This invention proposes a reagent bottle.

[0066] like Figures 1 to 8 As shown, an embodiment of the reagent bottle, reagent kit, cleaning system, and cleaning method of the present invention is presented.

[0067] In this embodiment, please refer to Figure 1 , Figure 2 This type of reagent bottle 10 includes:

[0068] The bottle body 100 has a first sealing plate 200 inside. The first sealing plate 200 divides the inner cavity of the bottle body 100 into a receiving space 110 for receiving reagents and a cleaning space 120 located above the receiving space 110. A first through hole 210 is formed on the first sealing plate 200 to connect the receiving space 110 and the cleaning space 120. An opening communicating with the cleaning space 120 is formed on the top of the bottle body 100.

[0069] A suction tube 300 is installed within the receiving space 110. The top of the suction tube 300 communicates with the first through hole 210, and the bottom of the suction tube 300 extends downward and communicates with the receiving space 110; and,

[0070] First sealing cover 400, the first sealing cover 400 closes and seals the opening;

[0071] The reagent needle tip can pass sequentially through the first sealing cap 400, the cleaning space 120, and the first through hole 210 before being snapped into the suction tube 300 to draw reagents stored in the storage space; or,

[0072] The reagent needle can be cleaned by discharging cleaning fluid into the cleaning space 120 when its tip retracts from the suction tube 300 into the cleaning space 120.

[0073] In this embodiment, by providing a bottle body 100, a suction tube 300, and a first sealing cap 400, a first sealing plate 200 is provided inside the bottle body 100. The first sealing plate 200 divides the inner cavity of the bottle body 100 into a receiving space 110 for containing reagents and a cleaning space 120 located above the receiving space 110. A first through hole 210 is formed on the first sealing plate 200 to connect the receiving space 110 and the cleaning space 120. An opening communicating with the cleaning space 120 is formed on the top of the bottle body 100, making the present invention... The present invention allows cleaning to be completed within the cleaning space 120 during use, eliminating the need to clean the containing space 110 and preventing contamination of the cleaning space 120 by the reagents in the containing space 110. Furthermore, a suction tube 300 is installed within the containing space 110, with its top connected to the first through hole 210 and its bottom extending downwards and connecting to the containing space 110. This allows the present invention to extract reagents placed in the containing space 110 using the suction tube 300 during use. This further prevents the reagent from contaminating the cleaning space 120. Then, a first sealing cap 400 is used to cover and seal the opening, allowing the reagent needle to pass sequentially through the first sealing cap 400, the cleaning space 120, and the first through hole 210 before being engaged in the suction tube 300 to draw the reagent stored in the storage space. This further enables the present invention to use the reagent needle to draw the reagent out of the suction tube 300 during use. Furthermore, because the reagent needle is engaged in the suction tube 300 during reagent draw, contamination of the cleaning space 120 by the reagent needle is also prevented. The contamination on the outer wall of the reagent needle allows the cleaning solution to be directly discharged into the cleaning space 120 as the needle tip retracts from the suction tube 300 into the cleaning space 120. This completes the cleaning of both the outer and inner walls of the reagent needle, reducing cleaning time and effectively improving cleaning efficiency. Since the cleaning process is completed within the cleaning space 120, the contamination of the reagent needle by residual time in the containment space 110 is avoided, resulting in a more thorough cleaning and ensuring the accuracy of the test results.

[0074] It should be specifically and clearly stated that, in this embodiment, the reagent bottle 10 can be discarded directly after the reagent is drawn and the reagent needle is cleaned, and the containing space 110 of the reagent bottle 10 is no longer considered for cleaning.

[0075] In some specific embodiments, the aspiration tube 300 includes a cleaning section 310, a flow guiding section 320 and a snap-fit ​​section 330 arranged sequentially from top to bottom. The top of the cleaning section 310 is connected to the first through hole 210. The snap-fit ​​section 330 can snap and seal with the needle tip of the reagent needle. The bottom of the snap-fit ​​section 330 is connected to the receiving space 110 and close to the inner bottom wall of the reagent bottle 10.

[0076] In this embodiment, the aspiration tube 300 is configured as a cleaning section 310, a flow guiding section 320, and a snap-fit ​​section 330 connected sequentially from top to bottom. The cleaning section 310 is connected to the first through hole 210, and the bottom of the snap-fit ​​section 330 is connected to the receiving space 110 and extends to the inner bottom wall of the reagent bottle 10. At the same time, the reagent needle can be snapped into the snap-fit ​​section 330. This allows the reagent needle to be snapped into the snap-fit ​​section 330 when drawing reagents, thus avoiding contamination of the reagent needle by the reagent. Meanwhile, the flow guiding section 320 is provided between the cleaning section 310 and the snap-fit ​​section 330, so that the invention can avoid contamination of the cleaning section 310 by residual reagents when using the invention.

[0077] It should be specifically and clearly stated that, in this embodiment, during specific implementation, the inner diameter of the cleaning section 310 should be larger than the inner diameter of the snap-fit ​​section 330, and the inner diameter of the guide section 320 should gradually decrease from top to bottom. Simultaneously, the connection between the guide section 320 and the cleaning section 310 should be a smooth transition.

[0078] In some specific embodiments, a flexible seal 500 is also provided in the cleaning section 310. The flexible seal 500 is located close to the guide section 320. The reagent needle passes through the first sealing cap 400, the cleaning space 120, the first through hole 210, and the flexible seal 500 in sequence, and then snaps into the snap-fit ​​section 330 to draw the reagent stored in the storage space through the snap-fit ​​section 330; or,

[0079] The reagent needle can discharge cleaning fluid into the cleaning space 120 to clean the reagent needle when its tip passes through the snap-fit ​​section 330, the guide section 320 and the flexible seal 500 and returns to the cleaning section 310.

[0080] In this embodiment, by providing a flexible seal 500 in the cleaning section 310, the present invention can separate the cleaning section 310 from the guide section 320 during use, thereby preventing the reagent bottle 10 of the present invention from flowing from the snap-fit ​​section 330 through the guide section 320 into the cleaning section 310 and causing contamination of the cleaning section 310 and the cleaning space 120.

[0081] In some specific embodiments, the first sealing plate 200 is also provided with a second through hole 220 spaced apart from the first through hole 210. The second through hole 220 connects the receiving space 110 and the cleaning space 120. When the reagent needle can retract into the cleaning section 310 after passing through the snap-fit ​​section 330, the guide section 320 and the flexible seal 500, the cleaning section 310, the cleaning space 120, the second through hole 220 and the receiving space 110 form a cleaning flow path for the cleaning fluid to flow.

[0082] In this embodiment, by providing second through holes 220 spaced apart from the first through holes 210 in the first sealing plate 200, the second through holes 220 connect the cleaning space 120 and the receiving space 110, and the cleaning section 310, the cleaning space 120, the second through holes 220 and the receiving space 110 form a cleaning flow path for the cleaning fluid to flow. This allows the cleaning fluid after cleaning the reagent needle to flow into the receiving space 110 from the cleaning flow path during use, thus realizing the function of storing the cleaning fluid after cleaning the reagent needle. It also ensures that after cleaning the reagent needle, there is no excess cleaning fluid remaining in the cleaning space 120, so that the reagent needle can be dried more effectively when it needs to be dried.

[0083] In some preferred embodiments, the first sealing plate 200 is inclined, and the second through hole 220 is formed at the lower part of the first sealing plate 200.

[0084] In this embodiment, the first sealing plate 200 is inclined and the second through hole 220 is formed at the lower part of the first sealing plate 200, so that the cleaning fluid can flow into the receiving space 110 more quickly through the second through hole 220 when the invention is in use.

[0085] In some specific embodiments, the reagent bottle 10 further includes a second sealing plate 600, which is stacked on top of the first sealing plate 200. The second sealing plate 600 has an insertion hole for inserting a reagent needle at the position opposite to the first through hole 210. When the reagent needle is inserted into the cleaning section 310 through the insertion hole, a gap is formed between the outer wall of the reagent needle and the edge of the insertion hole to connect the cleaning section 310 and the cleaning space 120 and allow the cleaning liquid to flow.

[0086] In this embodiment, a second sealing plate 600 is provided inside the reagent bottle 10, and the second sealing plate 600 is stacked on top of the first sealing plate 200. Then, an insertion hole for inserting a reagent needle is formed on the second sealing plate 600 at the position opposite to the first through hole 210. When the reagent needle is inserted into the cleaning section 310, a gap is formed between the outer wall of the reagent needle and the edge of the insertion hole, which connects the cleaning section 310 and the cleaning space 120 and allows the cleaning liquid to flow. Thus, when the reagent needle is cleaned in the cleaning section 310, the cleaning liquid in the cleaning section 310 can flow from the gap and flow into the receiving space 110 through the second through hole 220.

[0087] It should be specifically and clearly stated that in this embodiment, the second sealing plate 600 of the example also has a hole formed at the position opposite to the second through hole 220 to connect the cleaning space 120 and the second through hole 220. At the same time, in order to make the cleaning fluid have a better flow effect, the second sealing plate 600 is also inclined and the hole is located at the lower end of the second sealing plate 600.

[0088] In some specific embodiments, the second through hole 220 is also used for the insertion of the venting needle 30 to vent air into the receiving space 110 through the venting needle 30.

[0089] In this embodiment, during the specific implementation, when using the reagent needle to draw out the reagent from the containing space 110, the vent needle 30 needs to be inserted into the second vent hole to discharge air into the containing space 110 through the vent needle 30, so that the reagent in the containing space 110 is drawn out from the suction tube 300 by the reagent needle; during the stage of retracting the reagent needle from the snap-fit ​​section 330 into the cleaning space 120 and cleaning the reagent needle in the cleaning space 120, the vent needle 30 needs to be retracted from the second through hole 220 into the cleaning space 120 to discharge the air in the cleaning space 120 and the containing space 110.

[0090] In some specific embodiments, the reagent bottle 10 further includes a second sealing cap 700, which forms the bottom wall of the bottle body 100, and a liquid collection groove 800 is formed on the inner bottom wall of the second sealing cap 700 at the position corresponding to the snap-fit ​​section 330.

[0091] In this embodiment, by making the second sealing cap 700 form the bottom wall of the bottle body 100, and installing a liquid collection tank 800 for collecting liquid on the inner side of the second sealing cap 700, the present invention can make the reagent collect in the liquid collection tank 800 during use, which is convenient for aspiration.

[0092] Of course, it should be clearly emphasized that, in the preferred embodiment, the example reagent bottle 10 and all its components are made of a transparent material that meets medical standards. Furthermore, the inner bottom wall and side wall of the example reagent bottle 10 have a smooth transition, or the bottom wall of the reagent bottle 10 is hemispherical. In this embodiment, by providing the collection tank 800, the present invention avoids creating dead volume at the bottom of the reagent bottle during consumption, thus improving the utilization rate of the reagent bottle.

[0093] Based on the same technical concept, in a second aspect, the present invention also proposes a reagent kit 20, wherein a placement space is formed within the reagent kit 20, and various reagent bottles 10 such as those in the first aspect are inserted side by side in the placement space, wherein the tops of all reagent bottles 10 extend upward and are exposed outside the reagent kit 20.

[0094] In this embodiment, by forming a placement space within the reagent kit 20 and inserting various reagent bottles 10 as exemplified in the previous embodiments side by side within the placement space, the present invention enables the placement of different types of reagent bottles 10 within the reagent kit 20 to complete the aspiration and detection of reagents contained in the reagent bottles 10, and facilitates the replacement of reagent bottles 10.

[0095] It should be specifically and clearly stated that, in actual implementation, the top of the reagent kit 20 is provided with multiple spaced placement holes that are all connected to the placement space, and each placement hole corresponds to the placement of a reagent bottle 10.

[0096] Based on the same technical concept, in a third aspect, the present invention also proposes a reagent kit 20, wherein a plurality of reagent bottles 10 as in the first aspect are formed within the reagent kit 20, and the tops of all reagent bottles 10 extend upward to the outside of the reagent kit 20.

[0097] In this embodiment, by forming various reagent bottles 10 as exemplified in the previous embodiments within the reagent kit 20, the structure of the reagent kit 20 of the present invention can be integrally formed, which facilitates manufacturing.

[0098] It should be clarified that both types of reagent kits 20 exemplified in this embodiment are sequencing kits for medical use.

[0099] In some specific embodiments, an observation window 21 is formed on the outer wall of the reagent kit 20.

[0100] In this embodiment, by forming an observation window 21 on the outer wall of the reagent kit 20, the reagent kit 20 of the present invention can be better observed during use.

[0101] Based on the same technical concept, in a fourth aspect, the present invention also proposes a cleaning system, comprising:

[0102] For example, reagent bottle 10 in the first aspect;

[0103] reagent needles; and,

[0104] A power pump is connected to the reagent needle, and the power pump is connected to a storage tank for storing cleaning solution and / or a gas source through two pipelines, so that the power pump can pump cleaning solution and / or gas into the reagent needle.

[0105] In this embodiment, by setting up a reagent bottle 10, a reagent needle, and a power pump, the power pump pumps cleaning liquid or air into the reagent needle, thereby enabling the present invention to achieve automated cleaning and drying functions.

[0106] It should be specifically and clearly stated that, in this embodiment, the power pump is an existing device or apparatus that is already in use. Its specific structure and working principle have not been improved or designed in this embodiment, so they will not be described in detail here.

[0107] In this embodiment, the cleaning system also includes a lifting mechanism. The reagent needle is installed in the lifting mechanism. The lifting drive mechanism can drive the reagent needle to move downward and pass through the first sealing cover 400, the cleaning space 120 and the first through hole 210 in sequence before being engaged in the suction tube 300; or drive the reagent needle to move upward so as to retract from the suction tube 300 into the cleaning space 120.

[0108] or,

[0109] The cleaning system also includes a lifting mechanism. The reagent needle is installed in the lifting mechanism. The lifting mechanism can drive the reagent kit 20 to move upward so that the reagent needle passes through the first sealing cap 400, the cleaning space 120 and the first through hole 210 in sequence and is then engaged in the aspiration tube 300.

[0110] Alternatively, the reagent kit 20 can be driven downwards to retract the reagent needle from the pipette 300 into the cleaning space 120.

[0111] By setting up a lifting mechanism and installing the reagent needle on the lifting mechanism, the present invention enables the reagent needle to automatically lift and lower during use, effectively improving work efficiency.

[0112] Of course, in an exemplary embodiment, the cleaning system also includes an exhaust needle 30, which can penetrate the receiving space 110 and / or the cleaning space 120 to communicate with the outside of the reagent bottle 10.

[0113] Based on the same technical concept, in a fifth aspect, the present invention also proposes a cleaning method that applies the cleaning system of the third aspect;

[0114] The cleaning method includes the following steps:

[0115] S100: After the reagent needle has been inserted into the reagent tube and the reagent has been drawn, retract the needle tip into the cleaning space 120.

[0116] S200: Use a power pump to pump cleaning fluid into the reagent needle to complete the cleaning of the reagent needle within the cleaning space 120.

[0117] S300: Use a power pump to pump air into the reagent needle to dry the reagent needle within the cleaning space 120.

[0118] This invention comprises a bottle body 100, a suction tube 300, and a first sealing cap 400. A first sealing plate 200 is provided inside the bottle body 100, dividing the inner cavity of the bottle body 100 into a receiving space 110 for holding reagents and a cleaning space 120 located above the receiving space 110. A first through hole 210 is formed on the first sealing plate 200, connecting the receiving space 110 and the cleaning space 120. An opening communicating with the cleaning space 120 is formed at the top of the bottle body 100. This allows the invention to... The cleaning process can be completed within the cleaning space 120, eliminating the need to clean the containing space 110 and preventing contamination of the cleaning space 120 by the reagents in the containing space 110. Furthermore, a suction tube 300 is installed within the containing space 110. The top of the suction tube 300 communicates with the first through hole 210, and the bottom of the suction tube 300 extends downwards and communicates with the containing space 110. This allows the reagents placed in the containing space 110 to be suctioned out during use. This first step avoids contamination of the cleaning space 120 by the reagent. Then, a first sealing cap 400 is used to cover and seal the opening, allowing the reagent needle to pass sequentially through the first sealing cap 400, the cleaning space 120, and the first through-hole 210 before being engaged in the suction tube 300 to draw the reagent stored in the storage space. Furthermore, this invention allows the reagent needle to be used to draw the reagent out of the suction tube 300 during use. And because the reagent needle is engaged in the suction tube 300 during reagent drawout, contamination of the reagent with the test tube is also avoided. The contamination on the outer wall of the reagent needle allows the cleaning solution to be directly discharged into the cleaning space 120 as the needle tip retracts from the suction tube 300 into the cleaning space 120. This completes the cleaning of both the outer and inner walls of the reagent needle, reducing cleaning time and effectively improving cleaning efficiency. Since the cleaning process is completed within the cleaning space 120, the contamination of the reagent needle by residual time in the containment space 110 is avoided, resulting in a more thorough cleaning and ensuring the accuracy of the test results.

[0119] The above description is merely an optional embodiment of the present invention and does not limit the patent scope of the present invention. All equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A reagent bottle, characterized in that, include: The bottle body has a first sealing plate inside, which divides the inner cavity of the bottle body into a receiving space for containing reagents and a cleaning space located above the receiving space. A first through hole is formed on the first sealing plate to connect the receiving space and the cleaning space. An opening is formed on the top of the bottle body to connect with the cleaning space. A suction tube, installed within the receiving space, with its top communicating with the first through hole and its bottom extending downwards and communicating with the receiving space, the suction tube comprising a cleaning section, a guiding section, and a snap-fit ​​section arranged sequentially from top to bottom. The top of the cleaning section communicates with the first through hole, the snap-fit ​​section engages with and seals against the tip of the reagent needle, and the bottom of the snap-fit ​​section communicates with the receiving space and is close to the inner bottom wall of the reagent bottle; and... A first sealing cap, which closes and seals the opening; The cleaning section is also provided with a flexible seal. The flexible seal is located close to the flow guide section. The reagent needle passes through the first sealing cover, the cleaning space, the first through hole and the flexible seal in sequence and then snaps into the snap-fit ​​section to draw the reagent stored in the storage space through the snap-fit ​​section. After the reagent is drawn up, the reagent needle can discharge cleaning fluid into the cleaning space as its tip passes through the snap-fit ​​section, the guide section and the flexible seal and retracts into the cleaning section to clean the reagent needle. The reagent bottle also includes a second sealing plate, which is stacked on top of the first sealing plate. The second sealing plate has an insertion hole for inserting the reagent needle at the position opposite to the first through hole. When the reagent needle is inserted into the cleaning section through the insertion hole, a gap is formed between the outer wall of the reagent needle and the edge of the insertion hole to connect the cleaning section with the cleaning space and allow the cleaning liquid to flow.

2. The reagent bottle as described in claim 1, characterized in that, The inner diameter of the cleaning section is larger than the inner diameter of the snap-fit ​​section, and the inner diameter of the guide section gradually decreases from top to bottom.

3. The reagent bottle as described in claim 2, characterized in that, The first sealing plate is also provided with a second through hole spaced apart from the first through hole. The second through hole connects the accommodating space and the cleaning space. When the needle tip of the reagent needle retracts into the cleaning section after passing through the snap-fit ​​section, the flow guiding section and the flexible seal, the cleaning section, the cleaning space, the second through hole and the accommodating space form a cleaning flow path for the cleaning fluid to flow.

4. The reagent bottle as described in claim 3, characterized in that, The first sealing plate is inclined, and the second through hole is formed at the lower part of the first sealing plate.

5. The reagent bottle as described in claim 4, characterized in that, The second through hole is also used for the insertion of an air vent needle to vent air into the receiving space through the air vent needle.

6. The reagent bottle according to any one of claims 1 to 5, characterized in that, The reagent bottle also includes a second sealing cap, which forms the bottom wall of the bottle body. The inner bottom wall of the second sealing cap has a liquid collection groove formed at the position of the snap-fit ​​section.

7. A reagent kit, characterized in that, The reagent kit has a placement space within which multiple reagent bottles as described in any one of claims 1 to 6 are inserted side by side, and the tops of all the reagent bottles extend upward and are exposed outside the reagent kit.

8. A reagent kit, characterized in that, The kit contains a plurality of reagent bottles as described in any one of claims 1 to 6, the tops of all of the reagent bottles extending upwards beyond the kit.

9. The kit as described in claim 7 or 8, characterized in that, The outer wall of the reagent kit has an observation window.

10. A cleaning system, characterized in that, include: The reagent bottle as described in any one of claims 1 to 6; reagent needle; as well as, A power pump is connected to the reagent needle, and the power pump is connected to a storage tank for storing cleaning solution and a gas source through two pipelines, so that the power pump can pump cleaning solution and gas into the reagent needle.

11. The cleaning system as described in claim 10, characterized in that, The cleaning system also includes a lifting mechanism, and the reagent needle is mounted on the lifting mechanism.

12. The cleaning system as described in claim 11, characterized in that, The cleaning system also includes an exhaust needle that can penetrate the receiving space and / or the cleaning space, connecting the receiving space and / or the cleaning space to the outside of the reagent bottle.

13. A cleaning method, characterized in that, Apply the cleaning system as described in any one of claims 10 to 12; The cleaning method includes the following steps: After the reagent needle has been inserted into the reagent tube and the reagent has been drawn, the needle tip is retracted into the cleaning space. The cleaning solution is pumped into the reagent needle using the power pump to clean the reagent needle within the cleaning space.

14. The cleaning method as described in claim 13, characterized in that, After the step of pumping cleaning fluid into the reagent needle using the power pump to complete the cleaning of the reagent needle within the cleaning space, the method further includes: Air is pumped into the reagent needle using the power pump to dry the reagent needle within the cleaning space.

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