An imine small molecule and application thereof as a fluorescent probe in detection of heavy metal ions and A beta peptide

By developing imine-based small molecule fluorescent probes, the problem of simultaneously detecting multiple heavy metal ions and Aβ peptides in existing technologies has been solved, achieving high sensitivity and selectivity in multiplex detection, which has significant application prospects.

CN117430604BActive Publication Date: 2026-05-29GUANGDONG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG UNIV OF TECH
Filing Date
2023-10-23
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Most existing fluorescent probes can only be used for the detection of a single heavy metal, making it difficult to detect multiple heavy metal ions and Aβ peptides simultaneously, and they also have shortcomings in detection sensitivity and selectivity.

Method used

A small-molecule fluorescent probe based on imine was developed, capable of simultaneously detecting Zn2+, Cu2+ and Fe2+ heavy metal ions, and exhibiting specific binding ability to Aβ peptide, distinguishing different aggregation states through fluorescence response.

Benefits of technology

It achieves high sensitivity and selectivity in the detection of Zn2+, Cu2+, and Fe2+, with detection thresholds lower than drinking water standards, and can distinguish different aggregation states of Aβ peptides, providing a tool for Alzheimer's disease research.

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Abstract

The application belongs to the technical field of small-molecule fluorescent materials, and particularly relates to an imine small molecule and application of the imine small molecule as a fluorescent probe in detection of heavy metal ions and A beta peptide. 2+ In order to mine a multifunctional fluorescent material with a simple synthesis method, high sensitivity and a low detection limit, the application provides an imine small-molecule compound. 2+ The small molecule has high sensitivity and selectivity to Zn 2+ , Cu 2+ and Fe 2+ , wherein the small molecule shows a fluorescence 'off' effect to Cu 2+ and Fe 2+ , and shows a fluorescence 'on' effect to Zn 2+ . In addition, the small molecule can selectively combine with A beta peptide to produce a fluorescence 'on' effect, and the fluorescence is continuously enhanced with protein aggregation, so that different aggregation states of amyloid A beta can be distinguished. Therefore, the small molecule as the fluorescent probe can be used for simultaneously detecting Zn 2+ , Cu 2+ 0> , Fe 2+ 1> and amyloid beta aggregates, and has a wide application prospect.
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