A reagent cup cleaning device

By designing a multi-station cleaning device and optimizing the structure of the injection and aspiration needles, the problem of poor reagent cup cleaning effect was solved, achieving efficient cleaning and accurate detection.

CN117531797BActive Publication Date: 2026-03-24QINGDAO HIGHTOP BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-12-27
Publication Date
2026-03-24

AI Technical Summary

Technical Problem

The existing technology has poor reagent cup cleaning effect, resulting in inaccurate test results.

Method used

A reagent cup cleaning device was designed, including a plate, a drive unit, a liquid injection unit, a liquid aspiration unit, and a shaking unit. Through multiple cleaning and shaking operations, combined with the design of the liquid injection needle and the liquid aspiration needle, the cleaning effect and detection accuracy are ensured.

Benefits of technology

It achieves efficient reagent cup cleaning, reduces the erroneous discharge of the target substance, improves the accuracy of the test results, and increases the shaking efficiency and the service life of the device.

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Abstract

The application discloses a reagent cup cleaning device, a disc body, a first driving unit, a liquid injection unit, a liquid suction unit and a shaking unit, the disc body comprises a plurality of cup holders arranged circumferentially and used for accommodating reagent cups, a first station, a second station and a third station are sequentially arranged close to the disc body, the first driving unit is used for driving the disc body to rotate, the liquid injection unit is used for injecting liquid into the reagent cups at the first station and the second station, and the liquid injection unit comprises a liquid injection needle, the liquid suction unit is used for sucking solution in the reagent cups at the second station and the third station, and the liquid suction unit comprises a liquid suction needle, the shaking unit is arranged close to the first station or the second station and is used for shaking the reagent cups after liquid injection, wherein a liquid outlet of the liquid injection needle faces an outer wall surface of the liquid suction needle, so that the liquid suction needle after liquid suction can be conveniently cleaned. The application has reasonable structure, good cleaning effect and is favorable for the accuracy of detection results.
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Description

Technical Field

[0001] This invention relates to the field of reagent testing technology, specifically to a reagent cup cleaning device. Background Technology

[0002] Reagent testing is widely used in modern production. Regardless of the testing method used, it usually includes steps such as sample addition and cleaning. Generally speaking, the more times the cleaning is done, the more beneficial it is to reduce the amount of impurities. However, excessive cleaning may also cause the target substance to be mistakenly discharged. Therefore, how to ensure the cleaning effect while improving the accuracy of the test results has become an urgent problem to be solved. Summary of the Invention

[0003] This invention discloses a reagent cup cleaning device, which solves the technical problems of poor reagent cup cleaning effect and its detrimental effect on improving the accuracy of test results in the prior art. It has the technical advantages of reasonable structure, good cleaning effect, and improved accuracy of test results. The technical solution adopted is as follows:

[0004] A reagent cup cleaning device, comprising

[0005] The disc body includes several cup holders arranged circumferentially for holding reagent cups, and a first station, a second station and a third station are arranged sequentially along the rotation direction of the disc body. The first station is the operation start position, there are one or more second stations, and the third station is the operation end position.

[0006] The first driving unit can drive the disc to rotate in a stepwise manner, so that the reagent cups in each cup holder pass through the first station, the second station and the third station in sequence.

[0007] The liquid injection unit is used to inject liquid into reagent cups at the first and second work stations. It includes multiple liquid injection mounting plates, which are arranged corresponding to the positions of the first or second work stations. Each liquid injection mounting plate is equipped with an injection needle, which can inject liquid into the reagent cup at the corresponding position.

[0008] A liquid aspiration unit is used to aspirate solutions from reagent cups at the second and third work stations. It includes a liquid aspiration drive and multiple liquid aspiration mounting plates. The liquid aspiration drive is used to move the liquid aspiration mounting plates up and down. The multiple liquid aspiration mounting plates are arranged corresponding to the positions of the second or third work stations. Each liquid aspiration mounting plate is equipped with a liquid aspiration needle, which can aspirate solutions from reagent cups at the corresponding positions. The outlet of the liquid aspiration needle faces the outer wall of the liquid aspiration needle to facilitate cleaning of the liquid aspiration needle after aspiration.

[0009] A shaking unit is located near the first or second work station and is used to shake the reagent cup after liquid injection.

[0010] Based on the above technical solution, it also includes a movable seat and a liquid level sensing needle. The movable seat is movably connected to the liquid aspiration mounting plate through an elastic element. The liquid aspiration needle and the liquid level sensing needle are arranged side by side on the movable seat. The liquid level sensing needle is connected to an external controller for monitoring the liquid level in the test reagent cup.

[0011] Based on the above technical solution, a liquid suction hole is provided on the liquid injection mounting plate corresponding to the second work station position, and the liquid suction needle and liquid level sensing needle can be vertically inserted into the reagent cup through the liquid suction hole.

[0012] Based on the above technical solution, the injection mounting plate has multiple injection needle positions for fixing injection needles, and the injection needle positions are arranged around the liquid suction through hole.

[0013] Based on the above technical solution, there are two second workstations, and the intervals between adjacent first and second workstations, between two second workstations, and between the second and third workstations are consistent.

[0014] Based on the above technical solution, a magnetic strip is also provided on the periphery of the disc body, and the magnetic strip avoids the working position corresponding to the shaking unit.

[0015] Based on the above technical solution, the shaking unit includes a shaking drive, a power slide shaft, and a shaking sleeve. The shaking drive is fixedly installed and can transmit rotational motion to the power slide shaft. The lower side wall of the shaking sleeve includes a spirally extending groove. The power slide shaft extends into the groove and can contact the inner wall surface of the groove. The upper part of the shaking sleeve includes a shaking cavity with an upward opening and an eccentric arrangement. The bottom surface of the liquid injection mounting plate is provided with a protrusion corresponding to the position of the shaking unit. The shaking cavity can lift the reagent cup upward so that the mouth of the reagent cup abuts against the protrusion. When the shaking drive drives the power slide shaft to rotate, the power slide shaft can cause the shaking sleeve to rotate while displacing along its axial direction to lift and shake the reagent cup.

[0016] Based on the above technical solution, the shaking sleeve forming the chute includes an outer cylinder and an inner cylinder. The outer cylinder is made of metal, and the inner cylinder is made of wear-resistant nylon. It also includes a horizontal magnetic field. The shaking sleeve passes through the magnetic field, and when the chute passes through the magnetic field, the outer cylinder cuts the magnetic field lines to provide an Ampere force to overcome the gravity of the shaking sleeve.

[0017] Based on the above technical solution, the number of the sliding grooves is multiple and arranged around the circumference of the rocking sleeve, and the power sliding shaft is arranged in a one-to-one correspondence with the sliding groove.

[0018] Based on the above technical solution, the lower part of the shaking sleeve includes a hollow cavity, the sliding groove is formed on the side wall of the hollow cavity, the rotor end of the shaking drive is coaxially fixed with a bushing, the power sliding shaft is fixed on the upper end of the bushing, the bushing extends upward into the hollow wall, and the power sliding shaft extends radially along the bushing and extends into the sliding groove.

[0019] Beneficial effects

[0020] This invention features a rational structure with multiple stations arranged sequentially along the disc body to complete multiple cleaning operations. Furthermore, the outlet of the injection needle faces the outer wall of the aspiration needle, allowing the injection needle to simultaneously flush away reagent residue left on the outer wall of the aspiration needle after the previous aspiration. This reduces the accidental discharge of the target analyte from the test solution and ensures that the loss of the target analyte after multiple cleanings remains within the error range. Additionally, the aspiration needle and liquid level sensing needle can extend into the reagent cup through the aspiration through-hole on the injection mounting plate, resulting in a compact structure. Moreover, the aspiration needle and liquid level sensing needle are connected to the aspiration mounting plate via an elastic element, allowing the aspiration needle to flexibly contact the bottom of the reagent cup during aspiration, ensuring complete aspiration and improving cleaning efficiency. Simultaneously, the liquid level sensing needle moves synchronously with the aspiration needle, monitoring whether the liquid level has dropped to indicate whether the aspiration needle is blocked, thus improving the accuracy of the test results.

[0021] This invention includes magnetic strips disposed around the periphery of the disc, with the magnetic strips avoiding the work position corresponding to the shaking unit. The shaking unit has an eccentrically positioned shaking cavity, and the shaking sleeve includes a spirally extending groove. When the shaking drive rotates the power sliding shaft, the outer wall of the power sliding shaft abuts against the inner wall of the groove, thereby driving the shaking sleeve to rotate and move up and down simultaneously. This allows it to lift the reagent cup upwards to contact the protrusion on the liquid injection mounting plate, effectively shaking the reagent cup, or to move downwards to detach from the reagent cup. The structure is ingenious and low-cost. The single-drive method avoids switching drives, which greatly improves shaking efficiency and increases the detection speed. In addition, the power sliding shaft is rotatably connected to the rotor end of the drive unit, so that it can roll and contact the inner wall of the groove, avoiding jamming.

[0022] The shaking sleeve forming the groove in this invention includes a metal outer cylinder and a magnetic field. When the shaking sleeve lifts the reagent cup upwards to its upper limit, the outer cylinder rotates and cuts the magnetic field lines, generating a motional electromotive force. Electrons inside the outer cylinder move directionally under the action of the Lorentz force, generating a current, which in turn generates an upward Ampere force. This force overcomes the gravity of the shaking sleeve, allowing it to stably maintain itself at the upper limit, thus stably lifting the reagent cup for shaking. This design avoids overcoming the weight of the shaking sleeve by increasing its rotation speed, demonstrating ingenious design. Furthermore, the outer cylinder is fitted with a nylon inner cylinder, which has good wear resistance and can slide vertically to connect with the bushing, thus improving service life and reducing the weight of the shaking sleeve. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only one embodiment of the present invention. For those skilled in the art, other embodiments can be derived from the provided drawings without creative effort.

[0024] Figure 1 : A three-dimensional structural schematic diagram of the present invention;

[0025] Figure 2 : A schematic diagram of the disk's structure;

[0026] Figure 3 : A schematic diagram of the liquid injection unit and liquid suction unit at the second workstation;

[0027] Figure 4 Schematic diagram of the exploded structure of the liquid absorption unit;

[0028] Figure 5 : A three-dimensional structural diagram of the shaking unit;

[0029] Figure 6 : A three-dimensional structural diagram of the shaft assembly fitted onto the shaking drive;

[0030] Figure 7 : A three-dimensional structural diagram of the shaking sleeve;

[0031] Figure 8 : A three-dimensional structural diagram of the fixed base and magnetic block after assembly; Detailed Implementation

[0032] The following description and accompanying drawings fully illustrate specific embodiments described herein to enable those skilled in the art to practice them. Some embodiments may include or substitute parts and features of other embodiments. The scope of the embodiments herein encompasses the entire scope of the claims and all available equivalents thereof. Throughout this document, the terms “first,” “second,” etc., are used only to distinguish one element from another without requiring or implying any actual relationship or order between the elements. Indeed, a first element can also be referred to as a second element, and vice versa. Furthermore, the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a structure, apparatus, or device that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a structure, apparatus, or device. Without further limitation, an element defined by the phrase “comprising one…” does not exclude the presence of other identical elements in the structure, apparatus, or device that includes said element. The various embodiments described herein are presented in a progressive manner, with each embodiment focusing on its differences from other embodiments; similar or identical parts between embodiments can be referred to interchangeably.

[0033] The terms "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer" used in this document to indicate orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings. They are used solely for the convenience of describing the document and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. In the description herein, unless otherwise specified and limited, the terms "installed," "connected," and "linked" should be interpreted broadly. For example, they can refer to mechanical or electrical connections, or internal connections between two elements; they can be direct connections or indirect connections through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances.

[0034] In this document, unless otherwise stated, the term "multiple" means two or more.

[0035] In this article, the character " / " indicates that the objects before and after it are in an "or" relationship. For example, A / B means: A or B.

[0036] In this article, the term "and / or" describes an association between objects, indicating that three relationships can exist. For example, A and / or B means: A or B, or A and B.

[0037] This embodiment uses the cleaning of reagent cups for reagent detection using chemiluminescence immunoassay as an example. In a chemiluminescence immunoassay analyzer, the detection target immunoassay is generally separated from the target by a cleaning process. After removing unbound components from the reactants, the luminescence reaction is completed on the basis of the immunoassay, thereby finally obtaining the detection and analysis results.

[0038] like Figures 1-8 The reagent cup cleaning device shown includes a disc body 1, a first driving unit 2, a liquid injection unit 3, a liquid suction unit 4, and a shaking unit 5.

[0039] The disc body 1 includes several cup holders arranged circumferentially for holding reagent cups. The reagent cups can extend into the cup holders to move with the disc body 1, such as... Figure 1 As shown, a first station, two second stations, and a third station are sequentially arranged along the rotation direction of the disc body 1. The first station is the starting position of the operation. In this embodiment, the number of second stations is preferably two. The third station is the ending position of the operation, so that three effective cleaning operations can be completed. In addition, the intervals between adjacent first and second stations, between two second stations, and between second and third stations are consistent, which facilitates automated control. In this embodiment, the disc body 1 includes several support wheels 13, an inner disc 11, and an outer disc 12. The inner disc 11 is fixedly set, and the outer disc 12 is rotatably connected to the inner disc 11 through a bearing. A second gear is sleeved on the outer circumferential surface of the outer disc 12, and several cup holders are formed on the outer disc 12 for holding reagent cups. Several support wheels 13 are arranged circumferentially. Each support wheel 13 includes a shaft that is vertically fixed on the inner disk 11. A roller is rotatably connected to the shaft. The roller surface of the roller is concave inward and has an arc surface. The roller surface of the roller abuts against and matches the inner wall surface of the outer disk 12, thus guiding the outer disk 12 to rotate stably.

[0040] The first driving unit 2 can drive the disk body 1 to rotate in a step-by-step manner, so that the reagent cups in each cup holder pass through the first station, the second station and the third station in sequence. Specifically, the first driving unit 2 includes a first motor that is fixedly set. The rotor end of the first motor is coaxially fixedly connected to a first gear. The first gear meshes with a second gear, so that the rotational motion can be transmitted to the disk body 1. In this embodiment, the patent end of the first motor is coaxially fixedly connected to a first baffle. The outer edge of the first baffle is provided with a plurality of circumferentially arranged first slots. In addition, it also includes a first optocoupler set near the first baffle. The first optocoupler can identify the first slots and send signals to an external controller to monitor the running steps of the first motor, which helps to improve the running accuracy and prevent the occurrence of step loss.

[0041] The liquid injection unit 3 is used to inject liquid into reagent cups at the first and second workstations. It includes three liquid injection mounting plates 31, which are fixedly mounted on the inner plate 11 of the tray body 1 and located above the tray body 1. The liquid injection mounting plates 31 are positioned corresponding to the positions of the first or second workstations. Figure 1 As shown, at least the liquid injection mounting plate 31 corresponding to the second working position is provided with a liquid suction hole 32. In addition, the liquid injection mounting plate 31 is also provided with two liquid injection needle positions for fixing the liquid injection needle. The liquid injection needle positions are arranged around the liquid suction hole. Liquid injection needles 33 are installed on both liquid injection needle positions. In this embodiment, under normal working conditions, only one liquid injection needle 33 injects liquid into the reagent cup at the corresponding position. When the liquid injection needle is blocked, the other liquid injection needle 33 starts to work.

[0042] The liquid aspiration unit 4 is used to aspirate solutions from reagent cups at the second and third workstations. It includes a liquid aspiration drive and three liquid aspiration mounting plates 41. The liquid aspiration drive moves the three liquid aspiration mounting plates up and down synchronously. Specifically, the liquid aspiration drive includes a fixed second motor, and the three liquid aspiration mounting plates 41 are fixedly connected by an arc-shaped plate. It also includes a fixed vertical plate, and the arc-shaped plate is slidably connected to the vertical plate. The second motor can drive the arc-shaped plate to move up and down on the vertical plate through a synchronous belt pulley structure. In addition, a second stop bar is fixedly connected to the arc-shaped plate. The second stop bar extends vertically and has several second slots along its axial direction. It also includes a second optocoupler located near the second stop bar. The second optocoupler can identify the second slots and send signals to an external controller to monitor the running steps of the second motor, which helps to improve running accuracy and prevent the occurrence of step loss.

[0043] Three liquid suction mounting plates 41 are set corresponding to the positions of the second or third working station, such as... Figure 4As shown, each liquid suction mounting plate 41 is equipped with a liquid suction needle 42 and a liquid level sensing needle 43. It also includes a movable seat 44 and a sleeve 46. The sleeve 46 is fixedly connected to the liquid suction mounting plate 41 upwards. The movable seat 44 is fitted inside the sleeve 46 and is slidably connected to the liquid suction mounting plate 41. In this embodiment, the movable seat 44 is cylindrical and fitted with an elastic element 45. The elastic element 45 includes a spring; one end of the spring is fixedly connected to the liquid suction mounting plate 41, and the other end of the spring is fixedly connected to the movable seat 44. The movable seat 44 is fixedly connected to press its bottom surface tightly against the inner bottom surface of the sleeve 46. The aspiration needle 42 and the liquid level sensing needle 43 are arranged side-by-side on the movable seat 44 and pass through the sleeve 46. This allows the aspiration needle 42 to flexibly contact the bottom of the reagent cup during aspiration, ensuring complete aspiration and improving cleaning efficiency. Simultaneously, the liquid level sensing needle 43 moves synchronously with the aspiration needle 42, monitoring whether the liquid level has dropped, indicating whether the aspiration needle 42 is blocked, thus improving the accuracy of the test results. Furthermore, the liquid level sensing needle is existing technology and will not be described in detail here. It is connected to an external controller to monitor the liquid level inside the test reagent cup. Additionally, the aspiration needle 42 and the liquid level sensing needle 43 can vertically penetrate the aspiration through-hole 32 into the reagent cup, resulting in a more compact structure.

[0044] like Figure 3 As shown, the outlet of the injection needle 33 faces the outer wall of the aspiration needle 42 to facilitate cleaning of the aspiration needle 42 after aspiration. This can reduce the accidental discharge of the target substance in the test solution and ensure that the loss of the target substance after multiple cleanings is within the error range.

[0045] The shaking unit 5 is located near the first or second station and is used to shake the reagent cup after liquid injection. It also includes a magnetic strip 6 located around the plate 1, and the magnetic strip 6 avoids the station corresponding to the shaking unit 5, so that the shaking unit 5 can effectively shake the reagent in the reagent cup.

[0046] In this embodiment, as Figures 5-8 As shown, the shaking unit 5 includes a mounting base 58, a shaking drive 51, a power sliding shaft 52, and a shaking sleeve 54, with the mounting base 58 fixedly installed.

[0047] like Figure 6 As shown, the shaking drive 51 includes a motor, which is fixed on the mounting base 58 via a motor mount. The motor includes a rotor end. It also includes a bushing 53. The rotor end of the shaking drive 51 is coaxially fixed to the bushing 53. The power sliding shaft 52 is disposed on the bushing 53 and is located near the upper end of the bushing 53. Thus, the rotor end of the shaking drive 51 can transmit rotational motion to the power sliding shaft 52 through the bushing 53. The power sliding shaft 52 is horizontally disposed and extends radially along the rotor end.

[0048] like Figure 7As shown, the lower sidewall of the shaking sleeve 54 includes a spirally extending groove 541. Specifically, the lower part of the shaking sleeve 54 includes a hollow cavity that extends downward and forms a lower opening on the bottom surface of the shaking sleeve 54. The groove 541 is formed on the sidewall of the hollow cavity. In this embodiment, there are two grooves 541 arranged symmetrically. The two power sliding shafts 52 are shaft-shaped and integrally formed through the bushing 53, that is, the two ends of the power sliding shafts 52 extend into the two grooves 541 respectively. In other embodiments of the present invention, there may be more than two grooves 541 arranged circumferentially around the shaking sleeve 54, wherein the power sliding shafts 52 and the grooves 541 are arranged in a one-to-one correspondence. In addition, to reduce the friction between the power sliding shaft 52 and the inner wall of the groove 541, the power sliding shaft 52 is rotatably connected to the bushing 53. In this embodiment, the outer circumferential surface of the bushing 53 is stepped shaft-shaped, which makes it convenient for the lower end of the bushing 53 to be fitted onto the outside of the rotor end and fixed to the rotor end, and at the same time makes it convenient for the upper end of the bushing 53 to extend upward into the hollow cavity, thereby allowing both ends of the power sliding shaft 52 to extend into the groove 541.

[0049] In addition, the shaking sleeve forming the groove 541 includes an outer cylinder 5402 and an inner cylinder 5401. The outer cylinder 5402 is made of metal. In this embodiment, the outer cylinder 5402 is made of hard aluminum alloy, which has low density, high strength and high surface smoothness, so that the outer cylinder has a larger wall thickness under the same weight. The inner cylinder 5401 is made of wear-resistant nylon material, which has good stability. Even if the shaking sleeve moves up and down frequently and quickly, it still has good stability.

[0050] like Figure 7 As shown, the upper part of the shaking sleeve 54 includes a shaking cavity 542 with the opening facing upward and eccentrically arranged. The reagent cup can be placed in the shaking cavity 542, so that the shaking cavity lifts the reagent cup upward. The bottom surface of the liquid injection mounting plate is provided with a protrusion corresponding to the position of the shaking unit. Specifically, when the shaking drive 1 drives the power slide shaft 52 to rotate, the outer wall surface of the power slide shaft 52 abuts against the inner wall surface of the slide groove 541, so that the shaking sleeve 54 rotates while moving along its axial direction to lift the reagent cup upward, and make the upper port of the reagent cup abut against the fixed protrusion upward, shaking the reagent cup, or moving downward and disengaging from the reagent cup. Before the shaking sleeve 54 is completely disengaged from the reagent cup, the reagent cup can still be shaken, which is beneficial to improving the shaking effect.

[0051] like Figure 5 and 8As shown, a fixed seat 55 is also fixedly connected to the mounting base 58. The fixed seat 55 is sleeved on the outside of the shaking sleeve 54 and has a clearance fit with the shaking sleeve 54. Two symmetrically arranged magnetic blocks 56 are embedded in the fixed seat 55. The two magnetic blocks 56 are respectively arranged outside the shaking sleeve 54 and form a magnetic field between the two magnetic blocks 56. The magnetic field includes a number of magnetic field lines. The shaking sleeve 54 passes through the magnetic field. When the shaking sleeve 54 slides to the upper limit of its stroke, the shaking sleeve 54 and the motor rotor end rotate synchronously. In this embodiment, the shaking sleeve 54 and the electronic rotor end rotate counterclockwise synchronously at this time, causing the sliding groove to... 541 continuously cuts the magnetic field lines, and the electrons inside the aluminum alloy material move directionally from the inside out under the action of Lorentz force, forming a motional electromotive force, generating a continuous weak current, providing an Ampere force to overcome the gravity of the shaking sleeve 54. At the same time, the frictional force generated by the contact between the power sliding shaft 2 and the sliding groove 541 acts together on the shaking sleeve 54, so that the shaking sleeve 54 is stably maintained at the upper limit of its stroke, thereby stably supporting the reagent cup for shaking operation. This avoids overcoming the weight of the shaking sleeve 54 by increasing the rotational acceleration of the shaking sleeve 54, which is a clever design.

[0052] The portion of the shaking sleeve 54 extending upwards beyond the fixed base 55 is fixedly connected to an annular wing plate 57. When the shaking sleeve 54 slides to the lower limit position, the annular wing plate 57 can abut downwards against the fixed base 55 to limit the axial sliding of the shaking sleeve 54.

[0053] In addition, it also includes a shaking optical coupler 59, which is fixed on the mounting base 58. The shaking optical coupler 59 is electrically connected to an external controller and can identify the lower end of the shaking sleeve 54 to monitor the position status of the shaking sleeve 54. The optical coupler is existing technology and will not be described in detail here. Those skilled in the art can purchase it according to their needs.

[0054] Work process

[0055] Under normal operating conditions, the disc rotates in one step, allowing multiple workstations to operate simultaneously.

[0056] At the first station, the injection needle 33 first injects cleaning solution into the reagent cup at the corresponding position. At the next station, the shaking unit 5 shakes the reagent cup.

[0057] At the two second stations, the aspiration needle 42 and the liquid level sensing needle 43 move downward to perform aspiration on the reagent cup at the corresponding position. During aspiration, under the action of the spring, the end of the aspiration needle 42 flexibly abuts against the inner bottom surface of the reagent cup to completely aspirate the liquid. At the same time, the liquid level sensing needle monitors whether the liquid level has dropped. After the aspiration is completed, the aspiration needle 42 and the liquid level sensing needle 43 move upward synchronously to the initial position. Then, the injection needle 33 at the second station injects liquid. The injection needle 33 also flushes the end of the aspiration needle 42 to avoid loss of the effective target analyte. After the injection is completed, the reagent cup is transported to the next station, where the shaking unit 5 shakes the reagent cup.

[0058] At the third station, the aspiration needle 42 and the liquid level sensing needle 43 move downward to perform aspiration on the reagent cup at the corresponding position. During aspiration, under the action of the spring, the end of the aspiration needle 42 flexibly contacts the inner bottom surface of the reagent cup to completely aspirate the liquid. At the same time, the liquid level sensing needle 43 monitors whether the liquid level drops. After the aspiration is completed, the aspiration needle 42 and the liquid level sensing needle 43 move upward synchronously to the initial position.

[0059] Thus, the cleaning operation is completed, and the reagent cup continues to be transported forward for testing.

[0060] The working process of the shaking unit 5 is as follows:

[0061] Two sliding grooves 541 extend spirally, including an upper end and a lower end; under its own weight, the shaking sleeve 54 is at the lower limit of its stroke, the power sliding shaft 52 is at the upper end of the sliding groove 541 and abuts against the inner wall of the sliding groove 541, the external controller controls the motor to rotate counterclockwise, at this time the power sliding shaft 52 abuts against the inner wall of the sliding groove 541, driving the shaking sleeve 54 to rotate counterclockwise and move upward to the upper limit;

[0062] When the shaking sleeve 54 moves to the upper limit of its stroke, the slide groove 541 cuts the magnetic field lines, generating a motional electromotive force. Electrons in the outer cylinder 5402 move directionally from the inside to the outside under the action of the Lorentz force, generating a motional electromotive force, forming a current, and then generating an upward Ampere force. At the same time, the frictional force generated by the contact between the power slide shaft 2 and the slide groove 541 together overcomes the gravity of the shaking outer cylinder 54 and does work, so that the shaking sleeve 54 is stably held at the upper limit, thus stably supporting the reagent cup. At this time, the upper port of the reagent cup is in contact with the fixed protrusion, which facilitates stable shaking operation.

[0063] After the shaking operation is completed, the external controller rotates in the opposite direction, the slide 541 cuts the magnetic field lines and generates a downward Ampere force, causing the shaking sleeve 54 to quickly fall back to the lower limit. This can shorten the time interval between the next shaking operation and greatly improve the efficiency of the shaking operation.

[0064] This cycle repeats itself.

[0065] The present invention has been described above by way of example, but the present invention is not limited to the specific embodiments described above. Any modifications or variations made based on the present invention shall fall within the scope of protection claimed by the present invention.

Claims

1. A reagent cup cleaning device, characterized by, Comprising a disc body (1) comprising a plurality of cup holders arranged circumferentially for accommodating reagent cups, sequentially provided with a first station, a second station and a third station in the rotation direction of the disc body, the first station being an operation starting station, the second station having one or more, and the third station being an operation ending station; a first driving unit (2) capable of driving the disc body (1) to rotate step by step so that the reagent cups in each of the cup holders sequentially pass through the first station, the second station and the third station; a liquid injection unit (3) for injecting liquid into the reagent cups at the first station and the second station, comprising a plurality of liquid injection mounting plates (31) provided in correspondence with the positions of the first station or the second station, each of the liquid injection mounting plates (31) being provided with a liquid injection needle (33) capable of injecting liquid into the reagent cup at the corresponding position; a liquid suction unit (4) for sucking solution in the reagent cups at the second station and the third station, comprising a liquid suction drive (46) for driving a plurality of liquid suction mounting plates (41) to move up and down, and the plurality of liquid suction mounting plates (41) being provided in correspondence with the positions of the second station or the third station, each of the liquid suction mounting plates (41) being provided with a liquid suction needle (42) capable of sucking solution in the reagent cup at the corresponding position, and the liquid injection needle (33) having an outlet facing the outer wall of the liquid suction needle (42) to facilitate cleaning of the liquid suction needle (42) after suction; a shaking unit (5) provided close to the first station or the second station for shaking the reagent cup after liquid injection; a magnetic strip (6) provided on the circumferential side of the disc body, and the magnetic strip (6) avoiding the station corresponding to the shaking unit (5); the shaking unit (5) comprising a shaking drive (51), a power slide shaft (52) and a shaking sleeve (54), the shaking drive (51) being fixedly provided and capable of transmitting rotary motion to the power slide shaft (52), the side wall of the lower part of the shaking sleeve (54) comprising a spiral-shaped sliding groove (541), the power slide shaft (52) extending into the sliding groove (541) and being capable of contacting the inner wall of the sliding groove (541), the upper part of the shaking sleeve (54) comprising a shaking cavity (542) having an upward opening and being eccentrically provided, the bottom surface of the liquid injection mounting plate being provided with a protrusion corresponding to the position of the shaking unit, the shaking cavity (542) being capable of lifting the reagent cup upward so that the cup opening of the reagent cup abuts against the protrusion, and when the shaking drive (51) drives the power slide shaft (52) to rotate, the power slide shaft (52) can make the shaking sleeve (54) rotate while moving in the axial direction thereof to lift and shake the reagent cup; The mixing sleeve (54) forming the chute (541) comprises an outer sleeve (5402) made of metal and an inner sleeve (5401) made of wear-resistant nylon, and a horizontal magnetic field, the mixing sleeve (54) passes through the magnetic field, and when the chute (541) passes through the magnetic field, the outer sleeve (5402) cuts the magnetic field magnetic lines to provide the ampere force overcoming the gravity of the mixing sleeve (54).

2. The reagent cup washing apparatus according to claim 1, characterized by The device further comprises a movable seat (44) and a liquid level sensing needle (43), the movable seat (44) is movably connected with the liquid suction mounting plate (41) by an elastic member (45), the liquid suction needle (42) and the liquid level sensing needle (43) are arranged on the movable seat (44) side by side, and the liquid level sensing needle (43) is connected with an external controller for monitoring the liquid level in the reagent cup.

3. The reagent cup washing apparatus according to claim 2, characterized by The liquid suction mounting plate (31) corresponding to the second station position is provided with a liquid suction through hole (32), and the liquid suction needle (42) and the liquid level sensing needle (43) can vertically pass through the liquid suction through hole (32) and extend into the reagent cup.

4. The reagent cup washing apparatus according to claim 3, characterized by The liquid injection mounting plate (31) is provided with a plurality of liquid injection needle positions for fixing the liquid injection needle (33), and the liquid injection needle positions are arranged around the liquid suction through hole (32).

5. The reagent cup washing apparatus according to claim 1, wherein The second station has two, the distance between the adjacent first station and second station, between the two second stations, and between the second station and the third station is consistent.

6. The reagent cup cleaning apparatus according to any one of claims 1 to 4, characterized by The number of the chute (541) is multiple and is arranged circumferentially around the mixing sleeve (54), and the power sliding shaft (52) is arranged one-to-one corresponding to the chute (541).

7. The reagent cup washing apparatus according to claim 6, characterized by The lower part of the mixing sleeve (54) comprises a hollow cavity, the chute (541) is formed on the side wall of the hollow cavity, the rotor end of the mixing drive (51) is coaxially fixed with a shaft sleeve (53), the power sliding shaft (52) is fixedly arranged on the upper end of the shaft sleeve (53), the shaft sleeve (53) extends upward into the hollow wall, and the power sliding shaft (52) extends along the radial direction of the shaft sleeve and extends into the chute (541).

Citation Information

Patent Citations

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