A class of chromone derivatives and their preparation method and application

By extracting and isolating the chromone derivative Sonnerachromone AG from the fruit of Sonneratia apetala, the problem of lack of active ingredients for delaying aging in the existing technology was solved, and the lifespan and health status of Caenorhabditis elegans were significantly extended.

CN117534680BActive Publication Date: 2025-09-05GUANGXI UNIV OF CHINESE MEDICINE
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Patent Information

Application Number
CN202311476066.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-11-07
Publication Date
2025-09-05
Estimated Expiration
2043-11-07

AI Technical Summary

Technical Problem

There is little research on the medicinal active ingredients of the Sonneratia apetala fruit in the prior art, especially no reports on chromone compounds with anti-aging effects, and there is a lack of effective life-extending ingredients.

Method used

Chromone derivatives were extracted from the fruits of Sonneratia apetala, and the compound Sonnerachromone AG was prepared by ethanol extraction and separation on silica gel and gel chromatography columns. The compound was then added to NGM culture medium to extend the lifespan of Caenorhabditis elegans.

Benefits of technology

Sonnerachromone AG compounds significantly extend the lifespan of Caenorhabditis elegans, improve its healthy lifespan and mobility, and some compounds have better anti-aging activity than the positive control group.

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Abstract

The present invention relates to the field of utilization of marine medicinal biological resources, and in particular to a class of chromone derivatives, a preparation method and an application thereof. The present invention obtains chromone derivatives SonnerachromoneA-G (1-7) by extracting and separating the fruit of Sonneratia apetala, a mangrove tree. The chromone derivatives SonnerachromoneA-G are natural active ingredients and are new compounds. It is found that the chromone derivatives SonnerachromoneA-G all have good nematode aging activity, and some compounds have better aging activity than a positive control group. The chromone derivatives can be used alone or in combination as medicinal or non-medicinal anti-aging products, and have good medicinal and dietary supplement prospects.
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