Composite nanometer luminescent material, preparation method and application thereof, nanometer detection label and immunochromatographic test strip

By layer-by-layer modification of the surface of molybdenum disulfide nanosheets with cationic polymers and negatively charged quantum dots, composite nanoluminescent materials were prepared, enabling dual-mode detection of colorimetry and fluorescence. This solved the problem of low sensitivity in traditional colorimetric immunochromatography and improved detection sensitivity and multi-target analysis capabilities.

CN117586770BActive Publication Date: 2026-02-24JIANGSU MEDOMICS MEDICAL TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202311540643.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-11-20
Publication Date
2026-02-24
Estimated Expiration
2043-11-20

AI Technical Summary

Technical Problem

Traditional colorimetric immunochromatographic detection methods have low sensitivity and poor quantitative ability, and cannot directly read fluorescence signals with the naked eye, which limits their application in trace substance detection, especially in resource-scarce areas.

Method used

A composite nanoluminescent material, including molybdenum disulfide nanosheets and a fluorescent layer loaded on their surface, is prepared by a layer-by-layer self-assembly method. Combining colorimetric and fluorescence dual-mode detection, the colorimetric ability of molybdenum disulfide nanosheets and the fluorescence properties of quantum dots are utilized to achieve colorimetric/fluorescence dual-mode analysis.

Benefits of technology

It improves detection sensitivity, achieving a detection limit as low as 0.1 ng/mL for colorimetric signal observation, and increases fluorescence detection sensitivity by at least 46 times, broadening the detection range and making it suitable for multi-target analysis in complex food and experimental samples.

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Abstract

The application belongs to the technical field of immunochromatographic detection, and particularly relates to a composite nanoluminescent material, a preparation method and application thereof, a nanodetection label and an immunochromatographic test strip. The composite nanoluminescent material comprises molybdenum disulfide nanosheets and a fluorescent layer loaded on the surface of the molybdenum disulfide nanosheets, and the fluorescent layer is composed of a plurality of fluorescent unit layers, and each fluorescent unit layer comprises a cationic polymer self-assembly layer and a negative quantum dot layer which are arranged in a stack. The application utilizes the molybdenum disulfide nanosheets to load quantum dots to generate a co-enhanced colorimetric fluorescence signal, and exhibits a powerful ability of flexible, super-sensitive and multiplex detection of common agricultural drugs in competitive lateral flow immunoassay (LFA). The application can flexibly and simultaneously monitor two pesticides (clothianidin and carbendazim) and two veterinary drugs (kanamycin and chloramphenicol) in complex food and experimental samples, and widens the application range of the existing LFA technology.
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