A device for ensuring that a suspension is mixed and delivered without damage

Abstract

The application relates to the field of medicine production and discloses a device for guaranteeing mixing and lossless conveying of suspension liquid, which comprises a lifting platform, a shaking table, a control cabinet and a suspension support; the lifting platform comprises an upper platform layer, a lower platform layer and an internal lifting mechanism, the lower platform layer is a hollow structure, the upper platform layer is lifted to be separated from the lower platform layer or is lowered to be nested in the lower platform layer under the action of the internal lifting mechanism; the shaking table is placed on the upper platform layer; the control cabinet is provided with a power socket, a lifting button and a lowering button; and the suspension support comprises a vertical rod and a horizontal rod at the top of the vertical rod. The lifting platform and the shaking table are matched and used, the mixing effect of the suspension liquid with active substances such as cells is fully guaranteed when the liquid is conveyed, the uniformity of the sub-packaging is improved, the shaking table is lifted by the lifting platform, the liquid is conveyed by relying on the gravitational potential energy, the foam generated by external shaking is avoided, and the loss of the active substances such as cells caused by the extrusion of a peristaltic pump is avoided.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical production, and specifically to a device for ensuring the uniform mixing and lossless delivery of suspensions. Background Technology

[0002] Currently, pharmaceutical manufacturing primarily uses plastic or stainless steel containers and disposable bags, with silicone tubing used for liquid transport. When storing and transporting suspensions in plastic or stainless steel containers, compressed air is required as a power source, and external shaking is necessary to ensure uniform dispersion. However, vigorous shaking generates a large amount of foam, which can easily damage the cells and other active substances within the suspension. When storing and transporting suspensions in disposable bags, a shaker is used for mixing. Because disposable bags cannot be powered by compressed air, a peristaltic pump is required; however, the squeezing action of the peristaltic pump can easily cause the loss of cells and other active substances within the suspension. Summary of the Invention

[0003] To overcome the shortcomings of existing technologies, this invention provides a device for ensuring uniform mixing and lossless transport of suspensions, the technical solution of which is as follows:

[0004] A device for ensuring uniform mixing and lossless transport of a suspension includes a lifting platform, a shaking table, a control cabinet, and a suspension bracket. The lifting platform includes an upper platform, a lower platform, and an internal lifting mechanism. The lower platform is a hollow structure. The upper platform is raised or lowered by the internal lifting mechanism to be nested within the lower platform. A height fixing mechanism is provided between the upper and lower platforms to fix the upper platform at a corresponding height position. The shaking table is placed on the upper platform. The control cabinet is installed on the side of the lower platform and is equipped with a power socket, an up button, and a down button. The control cabinet is electrically connected to the shaking table and the internal lifting mechanism. The suspension bracket includes a vertical rod installed on the side of the lower platform and a horizontal rod at its top. The end of the horizontal rod is equipped with a hook for suspending a liquid storage bag.

[0005] Furthermore, the internal lifting mechanism includes a scissor lift, a hydraulic cylinder, a hydraulic pump, and a motor. The upper end of the scissor lift is hinged to the upper layer of the platform, and the lower end is hinged to the bottom of the lower layer of the platform. The hydraulic cylinder is installed at the lower part of the scissor lift and is hinged to the middle of the scissor lift through a piston rod. The hydraulic pump is connected to the hydraulic cylinder through an oil pipe, and the motor drives the hydraulic pump.

[0006] Furthermore, the vertical rod of the suspension bracket includes an upper rod and a lower rod, the lower rod being a hollow structure, and the upper rod being inserted into the lower rod; the upper rod and the lower rod are provided with corresponding bracket pin holes, and the upper rod can be fixed at the corresponding height position by means of matching pins.

[0007] Furthermore, the contact surfaces between the upper and lower layers of the platform are provided with fumigation-resistant silicone sealing strips; the upper layer of the platform is surrounded by guardrails; the upper part of the lower layer of the platform is provided with handrails, and the control cabinet is installed on one side of the handrails.

[0008] Furthermore, the height fixing mechanism includes platform pin holes and matching pins corresponding to the upper and lower layers of the platform.

[0009] Furthermore, the lower layer of the platform is equipped with omnidirectional casters.

[0010] Furthermore, the swivel casters are oil-free casters that are resistant to fumigation and disinfectants.

[0011] Furthermore, the control cabinet is equipped with an emergency stop button.

[0012] Furthermore, the outer surfaces of the upper platform, lower platform, control cabinet, suspension bracket, and shaking table are all made of stainless steel.

[0013] Furthermore, the shaker is a shaker or agitator that mixes the particles by oscillation.

[0014] The basic working principle of this invention is as follows:

[0015] To use, lower the lifting platform to its lowest position using the descent button. Place the suspension on the shaker of the lifting platform, connect the shaker to the power socket of the control cabinet, and start the shaker. Raise the lifting platform to its highest position using the descent button and insert the latch. This allows the liquid to mix evenly at the highest point and drain from the outlet pipe of the storage bag using gravitational potential energy. If a small amount of suspension remains in the storage bag and cannot be completely drained, suspend the storage bag on the hook at the end of the horizontal bar of the suspension bracket. Insert the vertical bar of the suspension bracket from the upper bar into the lower bar and use the matching latch to fix the upper bar at the appropriate height until the liquid in the bag is completely drained.

[0016] Compared with the prior art, the present invention has the following main advantages:

[0017] 1. This invention uses a lifting platform in conjunction with a shaking table. When transporting suspensions containing cells and other active substances, it not only ensures a good mixing effect and improves the uniformity of dispensing, but also raises the shaking table by lifting the platform and transports the liquid by relying on gravitational potential energy, thus avoiding the loss of cells and other active substances caused by foam generated by external shaking and the squeezing of the peristaltic pump.

[0018] 2. The upper platform of this invention is raised and lowered by a scissor-type hydraulic lifting structure, making it simple, flexible, and efficient to operate. A motor drives a hydraulic pump, which in turn applies mechanical energy to the scissor lift via a hydraulic cylinder. The scissor lift then moves the upper platform up and down. The raising and lowering of the upper platform is controlled by the forward and reverse rotation of the motor. When the upper platform is at its lowest position, it is mostly nested within the lower platform structure. When the upper platform rises, the scissor lift slowly raises it to its highest position, at which point a locking pin needs to be inserted. The upper platform can be raised or lowered to any position as needed.

[0019] 3. Compact structure and high level of automation.

[0020] 4. It can be easily moved to different work locations via swivel casters. Attached Figure Description

[0021] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0022] Figure 2 This is a schematic diagram of the internal lifting mechanism of the lifting platform of the present invention;

[0023] Figure 3 This is a schematic diagram of the main view of the present invention;

[0024] Figure 4 This is a schematic diagram of the left side of the present invention;

[0025] Figure 5 This is a top view of the present invention;

[0026] In the diagram: 1-shaking bed, 2-hook, 3-crossbar, 4-upper platform, 5-platform pin hole, 6-bracket pin hole, 7-lower platform, 8-vertical bar, 8.1-upper bar, 8.2-lower bar, 9-silicone sealing strip, 10-swivel casters, 11-raise button, 12-handrail, 13-power socket, 14-lower button, 15-guardrail, 16-scissor lift, 17-hydraulic cylinder, 18-hydraulic pump, 19-motor, 20-oil pipe. Detailed Implementation

[0027] The present invention will now be described in detail with reference to the embodiments and accompanying drawings. Example 1

[0028] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5A device for ensuring uniform mixing and lossless transport of a suspension includes a lifting platform, a shaking table 1, a control cabinet, and a suspension bracket. The lifting platform includes an upper platform 4, a lower platform 7, and an internal lifting mechanism. The lower platform 7 is a hollow structure. The upper platform 4 is raised or lowered to be nested within the lower platform 7 by the internal lifting mechanism. A height fixing mechanism is provided between the upper platform 4 and the lower platform 7 to fix the upper platform 4 at a corresponding height position. The shaking table 1 is placed on the upper platform 4. The control cabinet is installed on the side of the lower platform 7 and is equipped with a power socket 13, an up button 11, and a down button 14. The control cabinet is electrically connected to the shaking table 1 and the internal lifting mechanism. The suspension bracket includes a vertical rod 8 installed on the side of the lower platform 7 and a horizontal rod 3 at its top. The end of the horizontal rod 3 is provided with a hook 2 for suspending a liquid storage bag. Example 2

[0029] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 A device for ensuring uniform mixing and lossless transport of a suspension, based on the technical solution described in Example 1, includes an internal lifting mechanism comprising a scissor lift 16, a hydraulic cylinder 17, a hydraulic pump 18, and a motor 19. The upper end of the scissor lift 16 is hinged to the upper platform 4, and the lower end is hinged to the bottom of the lower platform 7. The hydraulic cylinder 17 is installed at the lower part of the scissor lift 16 and is hinged to the middle of the scissor lift 16 via a piston rod. The hydraulic pump 18 is connected to the hydraulic cylinder 17 via an oil pipe 20, and the motor 19 drives the hydraulic pump 18. Example 3

[0030] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 A device for ensuring uniform mixing and lossless transport of a suspension, based on the technical solution described in Embodiment 1, wherein the vertical rod 8 of the suspension bracket includes an upper rod 8.1 and a lower rod 8.2, the lower rod 8.2 being a hollow structure, and the upper rod 8.1 being inserted into the lower rod 8.2; the upper rod 8.1 and the lower rod 8.2 are provided with corresponding bracket pin holes 6, and the upper rod 8.1 can be fixed at the corresponding height position by means of matching pins. Example 4

[0031] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5A device for ensuring uniform mixing and damage-free transport of suspension, based on the technical solution described in Example 1, wherein the contact surface between the upper platform 4 and the lower platform 7 is provided with a fumigation-resistant silicone sealing strip 9 to reduce cleaning dead corners; a guardrail 15 is provided around the upper platform 4 to prevent slippage; a handrail 12 is provided on the upper part of the lower platform 7, and a control cabinet is installed on one side of the handrail 12. Example 5

[0032] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 A device for ensuring uniform mixing and lossless transport of a suspension, based on the technical solution described in Example 1, includes a height fixing mechanism comprising platform pin holes 5 and their matching pins correspondingly provided on the upper platform 4 and the lower platform 7. Example 6

[0033] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 A device for ensuring uniform mixing and lossless transport of suspension, based on the technical solution described in Example 1, wherein the lower layer 7 of the platform is provided with casters 10 for convenient and flexible movement; the casters 10 are preferably oil-free casters that are resistant to fumigation and disinfectants, do not produce shed material, and do not affect the environment of the clean area. Example 7

[0034] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 A device for ensuring uniform mixing and lossless transport of a suspension, based on the technical solution described in Example 1, includes an emergency stop button on the control cabinet so that operation can be stopped at any time in case of equipment malfunction. Example 8

[0035] See Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 A device for ensuring uniform mixing and lossless transport of suspension, based on the technical solution described in Example 1, wherein the outer surfaces of the upper platform 4, the lower platform 7, the control cabinet, the suspension bracket and the shaker 1 are all made of stainless steel, which is convenient to wipe without dead corners; the shaker 1 adopts a shaker or agitator that mixes by vibration.

[0036] The above division of embodiments is relative, and the technical solutions between embodiments can be flexibly combined according to the actual situation.

[0037] To enable those skilled in the art to better understand the present invention, its specific working process is briefly described below:

[0038] First, connect the shaker 1 to the power socket 13 of the device. Then, operate the lowering button 14 on the control cabinet to lower the upper level 4 of the lifting platform to its lowest point. Transfer the disposable bag containing the suspension to the shaker 1 on the lifting platform and start the shaker 1 to continuously mix the suspension in the disposable bag.

[0039] Operate the control cabinet's up button 11 to slowly raise the upper platform 4 of the lifting platform. After reaching the highest position, insert the pin into the platform's pin hole 5. The suspension in the disposable bag remains mixed under the influence of the shaker 1, and the suspension in the bag is discharged by gravity. When a small amount of liquid remains in the bag, first remove the pin from the platform's pin hole 5, and operate the control cabinet's down button 14 to lower the upper platform 4 of the lifting platform to its lowest point. Remove the disposable bag, suspend the end of the disposable bag at the end hook 2 of the suspension bracket's crossbar 3, with the liquid outlet of the disposable bag facing downwards. Then, lift the upper rod 8.1 from the lower rod 8.2 to a suitable height and fix it with the pin inserted into the bracket's pin hole 6, allowing the liquid to continue to be discharged by gravity.

Claims

1. A device for ensuring uniform mixing and lossless transport of a suspension, characterized in that, The system includes a lifting platform, a shaking table, a control cabinet, and a suspension bracket. The lifting platform comprises an upper platform, a lower platform, and an internal lifting mechanism. The lower platform is a hollow structure. The upper platform is raised by the internal lifting mechanism to leave the lower platform or lowered to nest within the lower platform. A height-fixing mechanism is provided between the upper and lower platforms to fix the upper platform at a corresponding height position. The shaking table is placed on the upper platform. The control cabinet is installed on the side of the lower platform and is equipped with a power socket, an up button, and a down button. The control cabinet is electrically connected to the shaking table and the internal lifting mechanism. The suspension bracket includes a vertical rod installed on the side of the lower platform and a horizontal rod at its top. The end of the horizontal rod is equipped with a hook for suspending a liquid storage bag. The internal lifting mechanism includes a scissor lift, a hydraulic cylinder, a hydraulic pump, and a motor. The upper end of the scissor lift is hinged to the upper layer of the platform, and the lower end is hinged to the bottom of the lower layer of the platform. The hydraulic cylinder is installed at the lower part of the scissor lift and is hinged to the middle part of the scissor lift through a piston rod. The hydraulic pump is connected to the hydraulic cylinder through an oil pipe, and the motor drives the hydraulic pump. The vertical rod of the suspension bracket includes an upper rod and a lower rod. The lower rod is a hollow structure, and the upper rod is inserted into the lower rod. The upper rod and the lower rod are provided with corresponding bracket pin holes, and the upper rod can be fixed at the corresponding height position by means of matching pins. The height fixing mechanism includes platform pin holes and matching pins correspondingly provided on the upper and lower layers of the platform. The outer surfaces of the upper and lower platforms, control cabinet, suspension bracket, and shaking table are all made of stainless steel. The shaker is a type of shaker that mixes particles through oscillation.

2. The device for ensuring uniform mixing and lossless transport of a suspension according to claim 1, characterized in that, The contact surfaces between the upper and lower levels of the platform are equipped with fumigation-resistant silicone sealing strips; the upper level of the platform is surrounded by guardrails; the upper part of the lower level of the platform is equipped with handrails, and the control cabinet is installed on one side of the handrails.

3. The device for ensuring uniform mixing and lossless transport of a suspension according to claim 1, characterized in that, The platform is equipped with omnidirectional casters on its lower level.

4. The device for ensuring uniform mixing and lossless transport of a suspension according to claim 3, characterized in that, The swivel casters are oil-free casters that are resistant to fumigation and disinfectants.

5. The device for ensuring uniform mixing and lossless transport of a suspension according to claim 1, characterized in that, The control cabinet is equipped with an emergency stop button.

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