A vacuum concentration device for preparing S-adenosyl methionine p-toluene sulfonic acid sulfate

Abstract

The present application relates to the technical field of vacuum concentration equipment, in particular to a vacuum concentration device for preparing S-adenosyl methionine p-toluenesulfonic acid sulfate, which comprises a vacuum pump, the gas outlet end of the vacuum pump is rotatably connected and communicated with a first gas guide pipe, the other end of the first gas guide pipe is fixedly connected and communicated with a condensation tank, one end of the vacuum pump is fixedly connected with a continuous device fixedly connected and communicated with the gas inlet end of the vacuum pump, and the other end of the continuous device is fixedly connected and communicated with constant temperature heating tanks arranged in a ring shape; the continuous device comprises an electric turntable fixedly connected to one end of the vacuum pump; by arranging the continuous device, the operator can divide the concentrated solution into several parts and fill them in the corresponding constant temperature heating tanks, and the vacuum pump can quickly extract the air and steam in the constant temperature heating tanks connected thereto under lower load.

Description

Technical Field

[0001] This invention relates to the field of vacuum concentration equipment technology, and in particular to a vacuum concentration apparatus for the preparation of S-adenosylmethionine p-toluenesulfonic acid sulfate. Background Technology

[0002] S-Adenosylmethionine p-toluenesulfonic acid sulfate (SAM-T) is a natural molecule found in all cells of the human body. It is present in high concentrations in the liver, adrenal glands, and pineal gland, and is evenly distributed in the brain. SAM-T provides multiple protective effects on hepatocytes through mechanisms such as anti-oxidation of free radicals and promotion of hepatocyte regeneration. Recent studies have also found that SAM-T can increase the fluidity of neuronal membranes in the brain of patients and promote the production of excitatory neurotransmitters, playing an important dual role in improving the mood of patients with liver disease and treating depression. Currently, manufacturers mostly use vacuum concentration equipment to concentrate and purify SAM-T solutions.

[0003] Because a large amount of solution needs to be added when concentrating and purifying S-adenosylmethionine p-toluenesulfonate solution, although this can increase the single extraction yield of S-adenosylmethionine p-toluenesulfonate sulfate, the large solution volume in the vacuum concentration device also leads to long evaporation time and uneven evaporation. Furthermore, as the evaporation time increases, S-adenosylmethionine p-toluenesulfonate sulfate crystals are more likely to coke on the inner wall of the vacuum concentration device, which not only affects the quality of S-adenosylmethionine p-toluenesulfonate sulfate, but also increases the cleaning burden on production personnel and the downtime maintenance time of the vacuum concentration device. Summary of the Invention

[0004] The purpose of this invention is to provide a vacuum concentration apparatus for the preparation of S-adenosylmethionine p-toluenesulfonate sulfate in order to solve the above-mentioned problems. This apparatus improves upon the existing vacuum concentration apparatus, which suffers from long concentration times, uneven evaporation, and a tendency for S-adenosylmethionine p-toluenesulfonate sulfate to crystallize and coke.

[0005] This invention achieves the above-mentioned objective through the following technical solution: a vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate, comprising a vacuum pump, a first gas guide pipe rotatably connected and connected to the outlet end of the vacuum pump, a condenser tank fixedly connected and connected to the other end of the first gas guide pipe, a continuous device fixedly connected and connected to the inlet end of the vacuum pump fixedly connected to one end of the vacuum pump, and a constant temperature heating tank arranged in a ring fixedly connected and connected to the other end of the continuous device; the continuous device includes an electric rotary table fixedly connected to one end of the vacuum pump, an opening and closing adjustment mechanism fixedly connected and connected to the inlet end of the vacuum pump sleeved on the surface of the vacuum pump, a second gas guide pipe fixedly connected and connected to the surface of the opening and closing adjustment mechanism, a sealing cover fixedly connected and connected to the vacuum pump fixedly connected to the other end of the second gas guide pipe, the constant temperature heating tank threadedly connected to the other end of the sealing cover, and a ring-shaped heating tank installed inside the opening and closing adjustment mechanism. The pressure relief mechanism is distributed in a circular pattern. One end of the pressure relief mechanism passes through the opening and closing adjustment mechanism and extends into the interior of the sealing cover. Inside the sealing cover is an anti-coking mechanism that engages with the constant-temperature heating tank. By setting up a continuous device, the operator can divide the concentrated solution into several portions and fill them into corresponding constant-temperature heating tanks. The vacuum pump can then quickly extract air and steam from the connected constant-temperature heating tank under a low load. Compared to existing designs that directly place a large amount of solution inside the vacuum concentration device, this reduces the volume of a single container. This not only reduces the vacuum pump's vacuuming burden, greatly improving its vacuuming efficiency and quality, but also reduces the depth of the solution that can be contained in a single container. This not only reduces the evaporation time of the solution but also allows substances reaching their boiling point inside the solution to evaporate more fully, reducing uneven evaporation and resulting in a higher concentration and fewer impurities in the vacuum-concentrated solution.

[0006] Preferably, the opening and closing adjustment mechanism includes a ring frame fitted onto the surface of the vacuum pump. A first arc groove is formed at one end of the ring frame, and a second arc groove communicating with the first arc groove is formed at the other end of the ring frame. The first and second arc grooves together form a circle. The depth of the first arc groove is greater than the depth of the second arc groove. Uniformly distributed guide balls are slidably connected to the inner walls of both the first and second arc grooves. A guide rod is fixedly connected to one end of each guide ball. The other end of the guide rod passes through either the first or second arc groove and the sealing cover, extending to the outside of the sealing cover. A mounting frame is fixedly connected to the other end of the guide rod. A rack is fixedly connected to one of the vertical inner walls of the mounting frame. A spur gear is meshed with the surface of the rack. The top of the spur gear, which is aligned with the first arc groove, contacts the inner top wall of the mounting frame, and the bottom of the spur gear, which is aligned with the second arc groove, contacts the inner bottom wall of the mounting frame. The rack can drive the spur gear to rotate at an effective angle of 90 degrees. One end of the spur gear is fixedly connected to a drive shaft. A spherical box is rotatably connected to the surface of the drive shaft. The air inlet of the vacuum pump and one end of the second air guide pipe are both fixedly connected and connected to the adjacent spherical box. The air inlet of the vacuum pump and one end of the second air guide pipe are symmetrically distributed on both sides of the center point of the spherical box. A sealing circular plate is fixedly connected to the surface of the drive shaft. The sealing circular plate, which is set on the same vertical line as the first arc groove, is parallel to the horizontal plane. The sealing circular plate, which is set on the same vertical line as the second arc groove, is perpendicular to the horizontal plane. Through the use of an electric turntable and an opening and closing adjustment mechanism, the constant temperature heating tank containing the solution can be connected and disconnected from the vacuum pump in sequence, so that the vacuum concentration operation can be carried out continuously. This effectively makes up for the disadvantage of low single effective concentration, so that the vacuum concentration device can simultaneously ensure the effective extraction amount and purity of S-adenosylmethionine p-toluenesulfonic acid sulfate solution.

[0007] Preferably, a sealing ring cover is rotatably connected to the other end of the ring frame. The top of the sealing ring cover has guide holes distributed in a ring shape. The other end of the guide rod extends through the outside of the guide holes. This can seal the first and second arc grooves without affecting the normal lifting and lowering of the guide rod, so as to prevent external dust, debris and other solid impurities from entering and reduce the operating burden of the guide ball.

[0008] Preferably, a rubber bellows is fixedly connected to the surface of the guide rod, and the other end of the rubber bellows is fixedly connected to the sealing ring cover. The guide hole is located inside the adjacent rubber bellows, which can seal the guide hole without affecting the normal lifting and lowering of the guide rod, further blocking dust.

[0009] Preferably, the surfaces of the guide ball and the guide rod are provided with interconnected guide channels. One end of the sealing cover is provided with a pressure relief hole communicating with the constant temperature heating tank. The pressure relief mechanism includes a T-shaped sealing plug, which is inserted into the pressure relief hole. The other end of the T-shaped sealing plug is fixedly connected to an n-shaped strip, the other end of which penetrates into the interior of the adjacent guide channel. The other end of the n-shaped strip is fixedly connected to an adjusting member, the other end of which passes through one of the guide channels and the other guide channel in sequence and contacts the inner bottom wall of the first or second arc groove. The adjusting member includes an arc strip and a connecting rod. The arc strip is fixedly connected to the inner bottom wall of the second arc groove. The length ratio of the arc strip to the second arc groove is 2:3. The arc strip is located on the side of the adjacent guide ball away from the adjacent guide rod. The connecting rod is fixedly connected to the other end of the n-shaped strip. An adjusting rod is slidably connected to the adjacent guide channel. The other end of the adjusting rod passes through one and the other guide channels in sequence and contacts the inner bottom wall of the first arc groove or the other end of the arc strip. The distance between the other end of the n-shaped strip, which is staggered with the arc strip, and one end of the adjacent adjusting rod is the same as the depth difference between the first and second arc grooves. The other end of the n-shaped strip, which is set on the same vertical line as the arc strip, contacts one end of the adjacent adjusting rod. By setting a pressure relief mechanism, when the constant temperature heating tank with the vacuum concentrated solution moves above the arc strip, the arc strip drives the T-shaped sealing plug to quickly separate from the pressure relief hole through the adjusting rod and the n-shaped strip, so that the air pressure inside the constant temperature heating tank quickly returns to normal. This not only allows the staff to quickly remove the constant temperature heating tank, but also shortens the time for replacing the constant temperature heating tank, thereby ensuring the overall working efficiency of the device.

[0010] Preferably, the adjusting component further includes a mounting bracket and a spring. The mounting bracket is slidably connected to the surface of the n-shaped strip, the T-shaped sealing plug is disposed inside the mounting bracket, and the spring is sleeved on the surface of the n-shaped strip. The spring is positioned between the mounting bracket and the T-shaped sealing plug, and the spring is always in a compressed state. This helps the T-shaped sealing plug to quickly and accurately connect with the pressure relief hole after losing resistance, eliminating the need for manual adjustment by the operator and further reducing the operator's workload.

[0011] Preferably, a filter screen is embedded in the surface of the mounting bracket, and the T-shaped sealing plug and spring are both located inside the filter screen. This can prevent air from carrying solid impurities into the constant temperature heating tank and reduce the probability of the solution inside the constant temperature heating tank being contaminated.

[0012] Preferably, the vertical inner wall of the constant temperature heating tank has two mounting slots. The anti-coking mechanism includes a mounting strip disposed inside the constant temperature heating tank. Both ends of the mounting strip penetrate into the mounting slots and are inserted into them. Two rotating seats are rotatably connected to the surface of the mounting strip. A fan impeller is rotatably connected between the two rotating seats. Both ends of the fan impeller penetrate to the outside of the rotating seats. A driving bevel gear is fixedly connected to both ends of the fan impeller. The other end of the driving bevel gear meshes with a driven bevel gear. The other end of the driven bevel gear is fixedly connected to a stirring shaft rotatably connected to the mounting strip. The other end of the stirring shaft passes through the mounting strip and extends into the interior of the constant temperature heating tank. By setting an anti-coking mechanism, during the process of the vacuum pump rapidly expelling the gas and steam inside the constant temperature heating tank, the airflow drives the impeller to rotate. The impeller drives the stirring shaft to rapidly stir the solution inside the constant temperature heating tank through the active bevel gear and the driven bevel gear, so that the substances inside the solution are stirred and rotated. Even if there is crystallized S-adenosylmethionine p-toluenesulfonate sulfate, the S-adenosylmethionine p-toluenesulfonate sulfate crystals will rotate with the solution under the action of stirring, reducing the probability of S-adenosylmethionine p-toluenesulfonate sulfate crystals coking on the inner wall of the constant temperature heating tank.

[0013] Preferably, the inner bottom wall of the sealing cover has an arc-shaped guide cavity that communicates with the second air guide tube. The surface of the fan impeller extends into the interior of the arc-shaped guide cavity. The connection between the second air guide tube and the arc-shaped guide cavity intersects with the axis of the fan impeller. This limits the airflow to entering the second air guide tube only through one side of the fan impeller axis, thus ensuring that the anti-coking mechanism can function properly for stirring.

[0014] The beneficial effects of this invention are:

[0015] 1. By setting up a continuous device, the operator can divide the concentrated solution into several portions and fill them into corresponding constant temperature heating tanks. At this time, the vacuum pump can quickly extract the air and steam inside the connected constant temperature heating tank under a low load. Compared with the existing design of directly placing a large amount of solution inside the vacuum concentration device, this reduces the volume of a single container of solution. This not only reduces the vacuum pump's vacuuming burden, greatly improving the vacuum pump's vacuuming efficiency and quality, but also reduces the depth of the solution that can be contained in a single container. This not only reduces the evaporation time of the solution, but also allows substances that have reached the boiling point inside the solution to be evaporated more fully, reducing uneven evaporation and resulting in a higher concentration and fewer impurities in the vacuum-concentrated solution.

[0016] 2. The electric turntable and the opening and closing adjustment mechanism work together to connect and disconnect the constant temperature heating tank containing the solution and the vacuum pump in sequence, so that the vacuum concentration operation can be carried out continuously. This effectively makes up for the shortcomings of low single effective concentration, and the vacuum concentration device can simultaneously ensure the effective extraction amount and purity of S-adenosylmethionine p-toluenesulfonic acid sulfate solution.

[0017] 3. By setting up a pressure relief mechanism, when the constant temperature heating tank with the vacuum concentrated solution moves above the arc strip, the arc strip drives the T-shaped sealing plug to quickly separate from the pressure relief hole through the adjusting rod and the n-shaped strip, so that the air pressure inside the constant temperature heating tank can quickly return to normal. This not only allows the staff to quickly remove the constant temperature heating tank, but also shortens the time for replacing the constant temperature heating tank, thereby ensuring the overall working efficiency of the device.

[0018] 4. By setting up an anti-coking mechanism, during the process of the vacuum pump rapidly expelling the gas and steam inside the constant temperature heating tank, the airflow drives the impeller to rotate. The impeller drives the stirring shaft to quickly stir the solution inside the constant temperature heating tank through the driving bevel gear and the driven bevel gear, so that the substances inside the solution are stirred and rotated. Even if there is crystallized S-adenosylmethionine p-toluenesulfonate sulfate, the S-adenosylmethionine p-toluenesulfonate sulfate crystals will rotate with the solution under the action of stirring, reducing the probability of S-adenosylmethionine p-toluenesulfonate sulfate crystals coking on the inner wall of the constant temperature heating tank. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of the present invention;

[0020] Figure 2 This is a schematic diagram of the continuous device in this invention;

[0021] Figure 3 This is a cross-sectional schematic diagram of the continuous device and the constant temperature heating tank in this invention;

[0022] Figure 4 for Figure 3 Enlarged view of A in the middle;

[0023] Figure 5 This is an exploded view of a partial section of the opening and closing adjustment mechanism and adjustment component in this invention;

[0024] Figure 6 This is a schematic diagram showing the connection between a partial cut-off structure of the opening and closing adjustment mechanism and the pressure relief mechanism in this invention;

[0025] Figure 7 This is a cross-sectional schematic diagram of the constant temperature heating tank, the second gas guide pipe, the sealing cover, and the anti-coking mechanism in this invention;

[0026] Figure 8 This is a cross-sectional schematic diagram of the opening and closing adjustment mechanism, the constant temperature heating tank, the second air guide pipe, the sealing cover, the pressure relief mechanism, and the anti-coking mechanism in this invention.

[0027] Figure 9 This is a cross-sectional schematic diagram of the T-shaped sealing plug, the partially cut n-shaped strip, and the partially cut adjustment component structure in this invention;

[0028] Figure 10 This is a schematic diagram of the anti-coking mechanism in this invention.

[0029] In the diagram: 1. Vacuum pump; 2. First gas guide pipe; 3. Condenser; 4. Continuous device; 5. Constant temperature heating tank; 501. Mounting slot; 6. Electric turntable; 7. Opening and closing adjustment mechanism; 701. Ring frame; 702. First arc groove; 703. Second arc groove; 704. Guide ball; 705. Guide rod; 706. Mounting frame; 707. Rack; 708. Spur gear; 709. Drive shaft; 710. Spherical box; 711. Sealing plate; 712. Sealing ring cover; 713. Guide hole; 714. Rubber bellows; 715. Guide channel; 8. Second gas guide pipe; 9. Sealing cover;

[0030] 901. Pressure relief hole; 902. Arc-shaped guide cavity; 10. Pressure relief mechanism; 1001. T-shaped sealing plug; 1002. N-shaped strip; 1003. Adjusting component; 10031. Arc strip; 10032. Connecting rod; 10033. Adjusting rod; 10034. Mounting bracket; 10035. Spring; 10036. Filter screen; 11. Anti-coking mechanism; 1101. Mounting strip; 1102. Rotating seat; 1103. Fan impeller; 1104. Driving bevel gear; 1105. Driven bevel gear; 1106. Stirring shaft. Detailed Implementation

[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0032] In practical implementation: such as Figure 1-10As shown, a vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate includes a vacuum pump 1. The outlet end of the vacuum pump 1 is rotatably connected to and communicates with a first gas guide pipe 2. The other end of the first gas guide pipe 2 is fixedly connected to and communicates with a condenser 3. One end of the vacuum pump 1 is fixedly connected to a continuous device 4, which is fixedly connected to and communicates with the inlet end of the vacuum pump 1. The other end of the continuous device 4 is fixedly connected to and communicates with a ring-shaped constant-temperature heating tank 5. The continuous device 4 includes an electric rotary table 6 fixedly connected to one end of the vacuum pump 1. The surface of the vacuum pump 1 is fitted with a vacuum pump 1... An opening and closing adjustment mechanism 7 is fixedly connected and communicated to the air inlet end of the air pump 1. A second air guide pipe 8 is fixedly connected and communicated to the surface of the opening and closing adjustment mechanism 7. The other end of the second air guide pipe 8 is fixedly connected and communicated to a sealing cover 9 fixedly connected to the vacuum pump 1. The constant temperature heating tank 5 is threadedly connected to the other end of the sealing cover 9. A pressure relief mechanism 10 distributed in a ring is installed inside the opening and closing adjustment mechanism 7. The other end of the pressure relief mechanism 10 passes through the opening and closing adjustment mechanism 7 and extends into the interior of the sealing cover 9. An anti-coking mechanism 11 that engages with the constant temperature heating tank 5 is installed inside the sealing cover 9.

[0033] like Figure 3-8As shown, the opening and closing adjustment mechanism 7 includes a ring frame 701, which is fitted onto the surface of the vacuum pump 1. A first arc groove 702 is formed at one end of the ring frame 701, and a second arc groove 703 communicating with the first arc groove 702 is formed at the other end of the ring frame 701. The first arc groove 702 and the second arc groove 703 together form a circle. The depth of the first arc groove 702 is greater than the depth of the second arc groove 703. Uniformly distributed guide balls 704 are slidably connected to the inner walls of both the first arc groove 702 and the second arc groove 703. A guide rod 705 is fixedly connected to one end of each guide ball 704, and the other end of the guide rod 705 passes through the first arc groove 702 in sequence. 2 or the second arc groove 703 and the sealing cover 9 and extending to the outside of the sealing cover 9, the other end of the guide rod 705 is fixedly connected to the mounting frame 706, one of the vertical inner walls of the mounting frame 706 is fixedly connected to the rack 707, the surface of the rack 707 is meshed with the spur gear 708, the top of the spur gear 708 which is set on the same vertical line as the first arc groove 702 contacts the inner top wall of the mounting frame 706, the bottom of the spur gear 708 which is set on the same vertical line as the second arc groove 703 contacts the inner bottom wall of the mounting frame 706, the effective angle by which the rack 707 can drive the spur gear 708 to rotate is ninety degrees, one end of the spur gear 708 is fixedly connected to A drive shaft 709 is provided, and a spherical box 710 is rotatably connected to the surface of the drive shaft 709. The air inlet end of the vacuum pump 1 and one end of the second air guide pipe 8 are both fixedly connected to and communicate with the adjacent spherical box 710. The air inlet end of the vacuum pump 1 and one end of the second air guide pipe 8 are symmetrically distributed on both sides of the center point of the spherical box 710. A sealing circular plate 711 is fixedly connected to the surface of the drive shaft 709. The sealing circular plate 711, which is set on the same vertical line as the first arc groove 702, is parallel to the horizontal plane, and the sealing circular plate 711, which is set on the same vertical line as the second arc groove 703, is perpendicular to the horizontal plane. The vertical cross-sectional shapes of the first arc groove 702 and the second arc groove 703 are matched. The convex shape of the guide ball 704 has the same diameter as the maximum cross-sectional inner diameter of the first arc groove 702 and the second arc groove 703. The inner wall of the connection between the first arc groove 702 and the second arc groove 703 is smooth and the corners are rounded. The other end of the ring frame 701 is rotatably connected to the sealing ring cover 712. The top of the sealing ring cover 712 is provided with a ring-shaped guide hole 713. The other end of the guide rod 705 extends through the outside of the guide hole 713. A rubber bellows 714 is fixedly connected to the surface of the guide rod 705. The other end of the rubber bellows 714 is fixedly connected to the sealing ring cover 712. The guide hole 713 is located inside the adjacent rubber bellows 714.

[0034] like Figure 3-9As shown, both the guide ball 704 and the guide rod 705 have interconnected guide channels 715 on their surfaces. One end of the sealing cover 9 has a pressure relief hole 901 that communicates with the constant temperature heating tank 5. The pressure relief mechanism 10 includes a T-shaped sealing plug 1001, which is inserted into the pressure relief hole 901. The other end of the T-shaped sealing plug 1001 is fixedly connected to an n-shaped strip 1002, and the other end of the n-shaped strip 1002 extends into the interior of the adjacent guide channel 715. The other end of the strip 1002 is fixedly connected to an adjusting member 1003. The other end of the adjusting member 1003 passes through one guide channel 715 and the other guide channel 715 in sequence and contacts the inner bottom wall of the first arc groove 702 or the second arc groove 703 {the center points of the n-shaped strip 1002 and the second arc groove 703 are set on the same vertical line}; the adjusting member 1003 includes an arc strip 10031 and a connecting rod 10032, the arc strip 10031 being fixedly connected to the second arc groove 702. The inner bottom wall of the arc groove 703 has an arc strip 10031 whose length ratio to the second arc groove 703 is 2:3. The arc strip 10031 is located on the side of the adjacent guide ball 704 away from the adjacent guide rod 705. The connecting rod 10032 is fixedly connected to the other end of the n-shaped strip 1002. The surface of the connecting rod 10032 is slidably connected to an adjusting rod 10033 that is slidably connected to the adjacent guide channel 715. The other end of the adjusting rod 10033 passes through one of the guide channels in sequence. Channel 715 and another guide channel 715 are in contact with the inner bottom wall of the first arc groove 702 or the other end of the arc strip 10031. The distance between the other end of the n-shaped strip 1002, which is staggered with the arc strip 10031, and one end of the adjacent adjusting rod 10033 is the same as the depth difference between the first arc groove 702 and the second arc groove 703. The other end of the n-shaped strip 1002, which is set on the same vertical line as the arc strip 10031, is in contact with one end of the adjacent adjusting rod 10033.Adjusting component 1003 also includes mounting bracket 10034 and spring 10035. Mounting bracket 10034 is slidably connected to the surface of n-shaped strip 1002. T-shaped sealing plug 1001 is disposed inside mounting bracket 10034. Spring 10035 is sleeved on the surface of n-shaped strip 1002. Spring 10035 is positioned between mounting bracket 10034 and T-shaped sealing plug 1001. Spring 10035 is always in a compressed state. {When guide ball 704 is not in the first arc groove 702 and second arc groove 703 on the arc strip} During the movement within the range of 10031, the guide ball 704 drives the adjusting rod 10033 to move through the guide channel 715. The adjusting rod 10033 is in contact with the inner bottom wall of the first arc groove 702 and the second arc groove 703. Even if the adjusting rod 10033 moves upward along the connection between the first arc groove 702 and the second arc groove 703, the adjusting rod 10033 can only move upward along the connecting rod 10032. When the guide ball 704 is completely inside the second arc groove 703, the end of the connecting rod 10032 is also just... When the adjusting rod 10033 contacts the n-shaped strip 1002, as it moves along the second arc groove 703 towards the arc strip 10031, it also moves upwards along the arc strip 10031. This causes the n-shaped strip 1002 to move upwards, and the n-shaped strip 1002 moves the T-shaped sealing plug 1001 out of the pressure relief hole 901. At this point, the interior of the constant temperature heating tank 5 is connected to the outside, and outside air quickly rushes into the constant temperature heating tank 5, causing the gas inside the constant temperature heating tank 5 to quickly return to normal. When the adjusting rod... When adjustment rod 10033 moves down along the arc strip 10031 back into the second arc groove 703, it drives the n-shaped strip 1002 down, which in turn drives the T-shaped sealing plug 1001 down. Spring 10035 quickly inserts the T-shaped sealing plug 1001 into the pressure relief hole 901, resealing it. A filter screen 10036 is embedded in the surface of the mounting bracket 10034, with the T-shaped sealing plug 1001 and spring 10035 both located inside the filter screen 10036.

[0035] like Figure 7 , Figure 8 and Figure 10As shown, the vertical inner wall of the constant temperature heating tank 5 has two mounting slots 501. The anti-coking mechanism 11 includes a mounting strip 1101, which is disposed inside the constant temperature heating tank 5. Both ends of the mounting strip 1101 pass through the interior of the mounting slot 501 and are inserted into the mounting slot 501. Two rotating seats 1102 are rotatably connected to the surface of the mounting strip 1101. A fan impeller 1103 is rotatably connected between the two rotating seats 1102. Both ends of the fan impeller 1103 are... The fan impeller 1103 extends to the outside of the rotating seat 1102. Both ends of the impeller 1103 are fixedly connected to a driving bevel gear 1104. The other end of the driving bevel gear 1104 is meshed with a driven bevel gear 1105. The other end of the driven bevel gear 1105 is fixedly connected to a stirring shaft 1106 that is rotatably connected to the mounting strip 1101. The other end of the stirring shaft 1106 passes through the mounting strip 1101 and extends into the interior of the constant temperature heating tank 5. The inner bottom wall of the sealing cover 9 has an arc-shaped guide cavity that communicates with the second air guide pipe 8. 902, the surface of the impeller 1103 extends into the interior of the arc-shaped guide cavity 902. The connection between the second air guide pipe 8 and the arc-shaped guide cavity 902 intersects with the axis of the impeller 1103. During the process of the vacuum pump 1 rapidly discharging gas and steam from the constant-temperature heating tank 5, the impeller 1103 blocks the necessary path of the airflow. The airflow directly impacts one side of the impeller 1103, causing it to rotate under the push of the airflow. The impeller 1103 drives the active bevel gear 1104 to rotate. The driving bevel gear 1104 drives the driven bevel gear 1105 to rotate, and the driven bevel gear 1105 drives the stirring shaft 1106 to quickly stir the solution inside the constant temperature heating tank 5, so that the substances inside the solution are stirred and rotated. Even if there is crystallized S-adenosylmethionine p-toluenesulfonate sulfate, the S-adenosylmethionine p-toluenesulfonate sulfate crystals will rotate with the solution under the action of stirring, reducing the probability of S-adenosylmethionine p-toluenesulfonate sulfate crystals coking on the inner wall of the constant temperature heating tank 5.

[0036] The operating procedure of this invention is as follows: First, the operator removes the empty constant temperature heating tank 5. Then, the solution to be concentrated is added into the constant temperature heating tank 5. Next, the constant temperature heating tank 5 is screwed onto the bottom of the sealing cap 9, which is directly above the second arc groove 703, and the constant temperature heating tank 5 is tightened onto the bottom of the sealing cap 9. Then, the constant temperature heating tank 5 and the electric turntable 6 are turned on simultaneously. The constant temperature heating tank 5 rapidly heats the solution to the specified temperature. Simultaneously, the electric turntable 6 drives the vacuum pump 1 to rotate. The vacuum pump 1 simultaneously drives all the spherical boxes 710 and the sealing cap 9 to rotate. The sealing cap 9 simultaneously drives the guide rod 705 and the constant temperature heating tank 5 to rotate. The guide rod 705 drives the guide ball 704 to enter the first arc groove 703 along the second arc groove 703. In step 2, during this process, the guide ball 704 moves rapidly downwards along the connection between the second arc groove 703 and the first arc groove 702. The guide ball 704 drives the guide rod 705 to move downwards, the guide rod 705 drives the mounting frame 706 to move downwards, the mounting frame 706 drives the rack 707 to move downwards, the rack 707 drives the spur gear 708 to rotate, the spur gear 708 drives the drive shaft 709 to rotate, and the drive shaft 709 drives the sealing disc 711 to rotate. When the guide ball 704 is completely inside the first arc groove 702, the sealing disc 711 is just in a horizontal state, and the interior of the spherical box 710 is no longer obstructed. The air inlet of the vacuum pump 1 is connected to the second air guide pipe 8 through the spherical box 710, and the vacuum pump 1 is connected to the second air guide pipe 8 through the second air guide pipe 8. The arc-shaped guide cavity 902 rapidly extracts air from the constant temperature heating tank 5, causing a sudden drop in air pressure inside the tank. This also rapidly lowers the boiling point of the solution. At this point, all substances in the solution except S-adenosylmethionine p-toluenesulfonic acid sulfate reach their boiling points and rapidly vaporize into steam. This steam is quickly discharged by the vacuum pump 1 through the arc-shaped guide cavity 902 and the second gas guide pipe 8 into the first gas guide pipe 2. The first gas guide pipe 2 guides the steam into the condenser tank 3, where it condenses into liquid. As the guide ball 704 moves along the first arc groove 702 to the second arc groove 703, it moves upwards along the connection between the first and second arc grooves. The guide ball 704 drives the guide rod 705 upwards. The mounting frame 706 moves upward, which in turn moves the rack 707 upward. The rack 707 drives the spur gear 708 to rotate in the opposite direction, which in turn drives the transmission shaft 709 to rotate in the opposite direction. The transmission shaft 709 drives the sealing disc 711 to rotate in the opposite direction. When the guide ball 704 is fully inside the second arc groove 703, the sealing disc 711 is in a vertical position. The sealing disc 711 cuts off the air inlet of the vacuum pump 1 from one end of the second air guide pipe 8, thus disconnecting the vacuum pump 1 from the second air guide pipe 8. At this point, the operator can unscrew the constant temperature heating tank 5 containing the solution concentrated to the corresponding concentration, and then screw the constant temperature heating tank 5 containing the solution to be concentrated back onto the other end of the empty sealing cover 9.

[0037] Compared to existing designs that directly place a large amount of solution inside a vacuum concentration device, this device can vacuum concentrate and purify S-adenosylmethionine p-toluenesulfonic acid sulfate solution in batches. Because the extraction volume per batch is reduced, the operating load of vacuum pump 1 is lower, the vacuuming efficiency is higher, and the depth of the solution that can be contained in a single container is also reduced. This not only reduces the evaporation time of the solution, but also allows substances that have reached the boiling point inside the solution to be evaporated more fully, reducing uneven evaporation. This results in a higher concentration of the vacuum-concentrated solution with fewer impurities. Furthermore, this device can continuously concentrate and purify S-adenosylmethionine p-toluenesulfonic acid sulfate solution, effectively compensating for the purification efficiency of the device.

[0038] It should be noted that the vacuum pump 1, condenser 3, constant temperature heating tank 5, and electric turntable 6 mentioned above are all devices with relatively mature existing technology. The specific models can be selected according to actual needs. At the same time, the vacuum pump 1, condenser 3, constant temperature heating tank 5, and electric turntable 6 can be powered by the built-in power supply or by the mains power. The specific power supply method should be selected according to the situation, and will not be elaborated here.

[0039] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate, comprising a vacuum pump (1), characterized in that: The outlet end of the vacuum pump (1) is rotatably connected to and connected to a first gas guide pipe (2), the other end of the first gas guide pipe (2) is fixedly connected to and connected to a condenser (3), one end of the vacuum pump (1) is fixedly connected to a continuous device (4) which is fixedly connected to and connected to the inlet end of the vacuum pump (1), and the other end of the continuous device (4) is fixedly connected to and connected to a constant temperature heating tank (5) arranged in a ring. The continuous device (4) includes an electric turntable (6) fixedly connected to one end of the vacuum pump (1). The surface of the vacuum pump (1) is fitted with an opening and closing adjustment mechanism (7) fixedly connected and communicating with the air inlet end of the vacuum pump (1). The surface of the opening and closing adjustment mechanism (7) is fixedly connected and communicating with a second air guide pipe (8). The other end of the second air guide pipe (8) is fixedly connected and communicating with a sealing cover (9) fixedly connected to the vacuum pump (1). The constant temperature heating tank (5) is threadedly connected to the other end of the sealing cover (9). The opening and closing adjustment mechanism (7) is equipped with a pressure relief mechanism (10) arranged in a ring shape. The other end of the pressure relief mechanism (10) passes through the opening and closing adjustment mechanism (7) and extends into the interior of the sealing cover (9). The interior of the sealing cover (9) is equipped with an anti-coking mechanism (11) that engages with the constant temperature heating tank (5). The opening and closing adjustment mechanism (7) includes a ring frame (701), which is fitted onto the surface of the vacuum pump (1). A first arc groove (702) is formed at one end of the ring frame (701), and a second arc groove (703) is formed at the other end of the ring frame (701) communicating with the first arc groove (702). The first arc groove (702) and the second arc groove (703) together form a circle. The depth of the first arc groove (702) is greater than the depth of the second arc groove (703). The inner wall of 03 is slidably connected with evenly distributed guide balls (704). One end of each guide ball (704) is fixedly connected to a guide rod (705). The other end of the guide rod (705) passes through the first arc groove (702) or the second arc groove (703) and the sealing cover (9) and extends to the outside of the sealing cover (9). The other end of the guide rod (705) is fixedly connected to a mounting frame (706). One of the vertical inner walls of the mounting frame (706) is fixedly connected to a rack (707). The surface of the rack (707) is meshed with a spur gear. 708), the top of the spur gear (708) which is set on the same vertical line as the first arc groove (702) contacts the inner top wall of the mounting frame (706), and the bottom of the spur gear (708) which is set on the same vertical line as the second arc groove (703) contacts the inner bottom wall of the mounting frame (706). The effective angle by which the rack (707) can drive the spur gear (708) to rotate is ninety degrees. One end of the spur gear (708) is fixedly connected to a drive shaft (709), and a spherical box (710) is rotatably connected to the surface of the drive shaft (709). The air inlet end of the vacuum pump (1) and one end of the second air guide pipe (8) are both fixedly connected and communicated with the adjacent spherical box (710). The air inlet end of the vacuum pump (1) and one end of the second air guide pipe (8) are symmetrically distributed on both sides of the center point of the spherical box (710). A sealing circular plate (711) is fixedly connected to the surface of the drive shaft (709). The sealing circular plate (711) which is set on the same vertical line as the first arc groove (702) is parallel to the horizontal plane, and the sealing circular plate (711) which is set on the same vertical line as the second arc groove (703) is perpendicular to the horizontal plane.

2. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 1, characterized in that: The other end of the ring frame (701) is rotatably connected to a sealing ring cover (712). The top of the sealing ring cover (712) is provided with a guide hole (713) distributed in a ring shape. The other end of the guide rod (705) extends through the outside of the guide hole (713).

3. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 2, characterized in that: A rubber bellows (714) is fixedly connected to the surface of the guide rod (705), and the other end of the rubber bellows (714) is fixedly connected to the sealing ring cover (712). The guide hole (713) is located inside the adjacent rubber bellows (714).

4. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 1, characterized in that: The surfaces of the guide ball (704) and the guide rod (705) are provided with interconnected guide channels (715). One end of the sealing cover (9) is provided with a pressure relief hole (901) that communicates with the constant temperature heating tank (5). The pressure relief mechanism (10) includes a T-shaped sealing plug (1001). The T-shaped sealing plug (1001) is inserted into the interior of the pressure relief hole (901). The other end of the T-shaped sealing plug (1001) is fixedly connected to an n-shaped strip (1002). The other end of the n-shaped strip (1002) extends into the interior of the adjacent guide channel (715). The other end of the n-shaped strip (1002) is fixedly connected to an adjusting member (1003). The other end of the adjusting member (1003) passes through one of the guide channels (715) and the other guide channel (715) in sequence and contacts the inner bottom wall of the first arc groove (702) or the second arc groove (703).

5. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 4, characterized in that: The adjusting component (1003) includes an arc strip (10031) and a connecting rod (10032). The arc strip (10031) is fixedly connected to the inner bottom wall of the second arc groove (703). The length ratio of the arc strip (10031) to the second arc groove (703) is 2:

3. The arc strip (10031) is located on the side of the adjacent guide ball (704) away from the adjacent guide rod (705). The connecting rod (10032) is fixedly connected to the other end of the n-shaped strip (1002). The surface of the connecting rod (10032) is slidably connected to the adjusting rod (1003) which is slidably connected to the adjacent guide channel (715). 3) The other end of the adjusting rod (10033) passes through one of the guide channels (715) and the other guide channel (715) in sequence and contacts the inner bottom wall of the first arc groove (702) or the other end of the arc strip (10031). The distance between the other end of the n-shaped strip (1002) which is staggered with the arc strip (10031) and one end of the adjacent adjusting rod (10033) is the same as the depth difference between the first arc groove (702) and the second arc groove (703). The other end of the n-shaped strip (1002) which is set on the same vertical line as the arc strip (10031) contacts one end of the adjacent adjusting rod (10033).

6. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 5, characterized in that: The adjusting component (1003) further includes a mounting bracket (10034) and a spring (10035). The mounting bracket (10034) is slidably connected to the surface of the n-shaped strip (1002). The T-shaped sealing plug (1001) is disposed inside the mounting bracket (10034). The spring (10035) is sleeved on the surface of the n-shaped strip (1002). The spring (10035) is positioned between the mounting bracket (10034) and the T-shaped sealing plug (1001). The spring (10035) is always in a compressed state.

7. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 6, characterized in that: A filter screen (10036) is embedded in the surface of the mounting bracket (10034), and the T-shaped sealing plug (1001) and the spring (10035) are both located inside the filter screen (10036).

8. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 1, characterized in that: The constant temperature heating tank (5) has two mounting slots (501) on its vertical inner wall. The anti-coking mechanism (11) includes a mounting strip (1101), which is disposed inside the constant temperature heating tank (5). Both ends of the mounting strip (1101) pass through the interior of the mounting slot (501) and are inserted into the mounting slot (501). Two rotating seats (1102) are rotatably connected to the surface of the mounting strip (1101), and a fan impeller (1103) is rotatably connected between the two rotating seats (1102). Both ends of the impeller (1103) extend to the outside of the rotating seat (1102). Both ends of the impeller (1103) are fixedly connected to a driving bevel gear (1104). The other end of the driving bevel gear (1104) is meshed with a driven bevel gear (1105). The other end of the driven bevel gear (1105) is fixedly connected to a stirring shaft (1106) that is rotatably connected to the mounting strip (1101). The other end of the stirring shaft (1106) extends through the mounting strip (1101) and into the interior of the constant temperature heating tank (5).

9. The vacuum concentration apparatus for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 8, characterized in that: The inner bottom wall of the sealing cover (9) is provided with an arc-shaped guide cavity (902) that communicates with the second air guide tube (8). The surface of the fan impeller (1103) extends into the interior of the arc-shaped guide cavity (902). The connection between the second air guide tube (8) and the arc-shaped guide cavity (902) intersects with the axis of the fan impeller (1103).

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