A rhodamine derivative-based high-selectivity copper ion ratio fluorescent probe, a preparation method and application thereof

By preparing a copper ion ratiometric fluorescent probe based on rhodamine derivatives, the problems of low sensitivity and poor selectivity in copper ion detection in the prior art were solved, and rapid and accurate copper ion detection and imaging were achieved.

CN117659030BActive Publication Date: 2026-06-30UNIV OF JINAN
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
UNIV OF JINAN
Filing Date
2023-10-24
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing fluorescent probe methods for detecting copper ions suffer from problems such as low sensitivity, poor selectivity, long response time, and significant interference from complex environmental factors, making it difficult to achieve rapid and accurate copper ion detection.

Method used

A highly selective copper ion ratio fluorescent probe based on rhodamine derivatives was prepared by reacting compound (I) with 2-hydroxyethylhydrazine to form fluorescent probe (I). The ratio of its fluorescence intensity at different wavelengths was used to identify copper ions, exhibiting high selectivity and high sensitivity.

Benefits of technology

It achieves highly selective recognition of copper ions, has strong anti-interference ability, rapid response, and can be applied under physiological conditions, making it suitable for fluorescence imaging of samples and cells.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN117659030B_ABST
    Figure CN117659030B_ABST
Patent Text Reader

Abstract

This invention discloses a highly selective copper ion ratiometric fluorescent probe based on a rhodamine derivative, its preparation method, and its applications, belonging to the field of fluorescent probes. Specifically, the probe of this invention can be used to measure, detect, or screen copper ions, achieving selective recognition of copper ions with strong anti-interference capabilities; it enables rapid and highly sensitive analysis of copper ions; it has colorimetric capabilities, thus facilitating visual detection of copper ions; it is a ratiometric fluorescent probe, eliminating the influence of various environmentally irrelevant factors and improving its sensitivity; it has low cytotoxicity, which is beneficial for application under physiological conditions; and it also has the advantages of simple synthesis, stable properties, and commercial application.
Need to check novelty before this filing date? Find Prior Art