A mouse isolator

Abstract

The application discloses a mouse isolator and particularly relates to the technical field of isolation experiment instruments, which comprises an isolation box plate for support, an isolation assembly is arranged on the isolation box plate, and the isolation assembly comprises two transparent isolation barrels arranged on the isolation box plate and used for separation. The second through hole and the first through hole are communicated with each other, the structures are easily communicated with each other, the convenience of sample storage and experiment is improved, the convenience in use is improved, sample escape can be avoided, the reinforced hollow isolation boxes can be moved to the first through hole one by one, different samples can be placed in the corresponding reinforced hollow isolation boxes through the first through hole by the staff, the confusion of sample information can be avoided, the opening of the reinforced hollow isolation box and the mesh plate can be closely combined with the inner wall of the transparent isolation barrel, the reinforced hollow isolation box and the mesh plate can not be loose, the isolation stability of the device in use is ensured, and the device is convenient to use and has good practicability.

Description

Technical Field

[0001] This invention relates to the field of isolation experimental equipment technology, and more specifically, to an isolator for rats. Background Technology

[0002] Gene editing, also known as genome editing or genome engineering, is a relatively new and precise genetic engineering technology or process that can modify specific target genes in an organism's genome. Gene editing relies on genetically engineered nucleases, also known as molecular scissors, to create site-specific double-strand breaks at specific locations in the genome, inducing the organism to repair them through non-homologous end joining or homologous recombination. Because this repair process is prone to errors, it can lead to targeted mutations.

[0003] In gene editing, laboratory mice are used as experimental subjects. During routine observation and breeding of these mice, isolators are used for isolation and culture to ensure their healthy growth. To maintain a sterile environment, the number of times the isolators are opened should be minimized to prevent the introduction of pathogens.

[0004] Among them, a search revealed that patent application number CN202222327791.1 discloses a large soft-pack isolator suitable for raising albino mice, including a stainless steel support frame and a soft pack. The soft pack is fixedly installed on the stainless steel support frame. The soft pack is provided with a docking mechanism for transfer. The side wall of the soft pack is provided with a ventilation mechanism. The docking mechanism includes a circular pipe, and the end of the circular pipe is threaded onto the soft pack.

[0005] When using this structure, during daytime working hours, the working lighting intensity inside the isolator is too strong for albino mice. The presence of the soft padding on this isolation bag can effectively reduce the transmittance of ambient light, thereby maintaining a suitable light intensity for animal rearing within the isolation bag. Outside of working hours, the illuminance is lower, and the presence of the soft padding on this isolation bag can ensure high light transmittance under low ambient light intensity, generally maintaining the light intensity requirements for animal rearing. However, this structure is not easy to isolate different samples during use, nor is it easy to remove different samples individually, making it inconvenient to use. Summary of the Invention

[0006] In order to overcome the above-mentioned defects of the prior art, the present invention provides a rodent isolator, which aims to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A rodent isolator includes an isolation box plate for support, on which an isolation assembly is provided. The isolation assembly includes two transparent, hollow-structured compartments disposed on the isolation box plate. A support column is located in the center of each transparent compartment. Several reinforced hollow compartments are distributed around the outer side of the column and along its circumference. A horizontal plate is provided on one side of each reinforced hollow compartment. Several support poles are provided at the top and bottom of each horizontal plate, and a ventilation mesh is provided on one side of each support pole. The plate, the top and bottom of the reinforced hollow compartment are provided with clip covers that are detachably connected to the reinforced hollow compartment. One side of each of the two clip covers is movably connected with a limiting shaft seat for support. The outer side of the limiting shaft seat is provided with a reinforcing frame extending to the column, and each of the two adjacent limiting shaft seats is provided with a limiting shaft for limiting. The outer side of the column and along the circumference of the column's axis are a number of extension columns located on one side of the corresponding mesh plate, and one end of each extension column is provided with a limiting plate for support. The top and one side of the limiting plate are provided with springs installed on the mesh plate.

[0009] As can be seen, in the above technical solution, each reinforced hollow compartment can be moved to the first through hole one by one, making it easy for staff to place different samples into the corresponding reinforced hollow compartments through the first through hole, avoiding sample information confusion. Furthermore, when the reinforced hollow compartment rotates, the reinforced hollow compartment and the mesh plate can be driven by the elasticity of the spring itself to rotate along the axis point at the connection between the cover and the limiting shaft seat, so that the opening of the reinforced hollow compartment and the mesh plate can fit tightly against the inner wall of the transparent compartment, preventing the reinforced hollow compartment and the mesh plate from becoming loose, and ensuring the isolation stability of the device during use.

[0010] Both transparent partitions are provided with access frame plates on their outer sides. The access frame plates are provided with outer clamping plates for support on their outer sides. A sliding plate for blocking is provided between the access frame plates and the outer clamping plates. The outer sides of the transparent partitions, located at the top and bottom of the horizontal plate, are provided with first through holes extending to one side of the access frame plates. The access frame plates, outer clamping plates, and sliding plates are all provided with second through holes that communicate with each other. Two guide blocks, both located on the outer sides of the sliding plate, are provided between the access frame plates and the outer clamping plates. The guide blocks are provided with guide grooves that are slidably connected to the sliding plate.

[0011] As can be seen, in the above technical solution, the sliding plate is moved on the guide block and the storage frame plate by the guide groove, so that the second through hole on the sliding plate can be connected with the second through hole and the first through hole on the outer card plate and the storage frame plate. This facilitates the connection of various structures, improves the convenience of sample storage and retrieval and experimentation, and enhances the convenience of use. Subsequently, the sliding plate can also block the second through hole on the storage frame plate and the outer card plate by its own weight, preventing the sample from escaping.

[0012] Both transparent partitions are provided with protective covers at their top for partitioning, and each protective cover is provided with a partition in the middle. Several second guide holes are distributed around the outer side of the protective cover and along the circumference of the protective cover's axis. A clamping plate is provided at the bottom of the partition and is installed on the top of the transparent partition and engaged with the transparent partition. Several first guide holes for guiding flow are distributed around the clamping plate and along the circumference of the clamping plate's axis. A fan for heat dissipation and ventilation is provided at the bottom of the clamping plate. Blades are provided on one side of the inner wall of the first guide holes.

[0013] As can be seen, in the above technical solution, the airflow inside the transparent partition is discharged through the first guide hole and the second guide hole by the operation of the fan, and the airflow inside the transparent partition can be discharged through the mesh plate for ventilation treatment when the device is in use.

[0014] The technical effects and advantages of this invention are as follows:

[0015] 1. When in use, the slide plate is pulled and moved on the guide block and the access frame plate by the guide groove, so that the second through hole on the slide plate can be connected with the second through hole and the first through hole on the outer card plate and the access frame plate, which facilitates the connection of various structures, improves the access of samples and the convenience of experiments, and improves the convenience of use.

[0016] 2. In this invention, during sample storage and retrieval, the sliding plate can also block the second through hole on the storage frame plate and the outer card plate by its own weight, thus preventing the sample from escaping;

[0017] 3. The present invention drives multiple reinforced hollow compartments to rotate and shift along the axis of the column by rotating the column, so that each reinforced hollow compartment can be moved to the first through hole one by one. This makes it easy for staff to place different samples into the corresponding reinforced hollow compartments through the first through hole, avoiding the situation of sample information confusion.

[0018] 4. In this invention, the reinforced hollow partition and the mesh plate can be driven by the elasticity of the spring to rotate along the axis point at the connection between the cover and the limiting shaft seat, so that the opening of the reinforced hollow partition and the mesh plate can be tightly fitted to the inner wall of the transparent partition, avoiding the reinforcement of the hollow partition and the mesh plate from becoming loose, ensuring the isolation stability of the device during use, and the airflow inside the transparent partition can be discharged through the mesh plate for ventilation during use of the device;

[0019] In summary, the overall design is simple and the structure is reasonable. Through the corresponding cooperation of various structures, the second through hole and the first through hole are interconnected, which facilitates the connection of various structures, improves the convenience of sample storage and retrieval and experiments, and enhances the ease of use. The sliding plate can also seal the first through hole by its own weight, preventing sample escape. Each reinforced hollow compartment can be moved to the first through hole one by one, making it easy for staff to place different samples into the corresponding reinforced hollow compartment through the first through hole, avoiding sample information confusion. The openings of the reinforced hollow compartments and the mesh plate can fit tightly against the inner wall of the transparent compartment, preventing the reinforced hollow compartments and the mesh plate from becoming loose, ensuring the isolation stability of the device during use, and providing both ease of use and good practicality. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in this disclosure, the accompanying drawings used in some embodiments of this disclosure will be briefly described below. Obviously, the drawings described below are only drawings of some embodiments of this disclosure, and those skilled in the art can obtain other drawings based on these drawings. In addition, the drawings described below can be regarded as schematic diagrams and are not intended to limit the actual size of the product, the actual flow of the method, the actual timing of the signals, etc. involved in the embodiments of this disclosure.

[0021] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0022] Figure 2 This is a front view of the isolation component of the present invention.

[0023] Figure 3 This is a front view of the various structures on the access frame of the present invention.

[0024] Figure 4 This is a top view of the isolation component of the present invention.

[0025] Figure 5 The front view of the reinforced hollow compartment and the column installed on the outside of the column is shown in the present invention.

[0026] Figure 6 This is a front view of the various structures on the protective cover and card plate of the present invention.

[0027] In the diagram: 1. Isolation box plate; 101. Protective cover; 102. Partition plate; 103. Clamping plate; 104. First guide hole; 105. Blade; 106. Fan; 107. Second guide hole;

[0028] 2. Transparent partition cylinder; 201. Column; 202. Reinforced hollow partition box; 203. Horizontal plate; 204. Mesh plate; 205. Upright pole; 206. Cover; 207. Limiting shaft seat; 208. Reinforcing frame; 209. Limiting shaft; 210. Extension column; 211. Limiting plate; 212. Spring;

[0029] 3. Storage frame plate; 301. Outer card plate; 302. Slide plate; 303. First through hole; 304. Second through hole; 305. Guide block; 306. Guide groove. Detailed Implementation

[0030] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0031] The terms "first," "second," and "third" used in the embodiments of this application are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first," "second," or "third" may explicitly or implicitly include at least one of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products, or devices.

[0032] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a mutually exclusive, independent, or alternative embodiment. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0033] As attached Figure 1-6The rat isolator shown here, through the isolation components set on the isolation box plate 1, allows the second through hole 304 and the first through hole 303 to be interconnected, which facilitates the connection of various structures, improves the accessibility of samples and the convenience of experiments, and enhances the ease of use. The slide plate 302 can also block the first through hole 303 by its own weight, preventing the sample from escaping. Each reinforced hollow compartment 202 can be moved to the first through hole 303 one by one, making it easy for staff to place different samples into the corresponding reinforced hollow compartment 202 through the first through hole 303, avoiding the confusion of sample information. The openings of the reinforced hollow compartment 202 and the mesh plate 204 can be tightly fitted to the inner wall of the transparent compartment 2, preventing the reinforced hollow compartment 202 and the mesh plate 204 from becoming loose, ensuring the isolation stability of the device during use. It is convenient to use and has good practicality. The specific structural settings of the components are as follows.

[0034] The isolation assembly includes two transparent cylinders 2 for separation, mounted on an isolation box plate 1. Each transparent cylinder 2 has a hollow structure, and a support column 201 is located in the center of each cylinder 2. Several reinforced hollow compartments 202 for separation are distributed around the outer side of the support column 201 and along its circumference. A horizontal plate 203 for separation is located on one side of each reinforced hollow compartment 202. Several support poles 205 are located at the top and bottom of each horizontal plate 203, and a ventilation mesh 204 is located on one side of each support pole 205. The top and bottom of each reinforced hollow compartment 202 are also equipped with [missing information - likely related to ventilation]. 202 Detachable cover 206, one side of each cover 206 is movably connected with a limiting shaft seat 207 for support, the outer side of the limiting shaft seat 207 is provided with a reinforcing frame 208 extending to the column 201, and each pair of adjacent limiting shaft seats 207 is provided with a limiting shaft 209 for limiting, the outer side of the column 201 and along the circumference of the axis of the column 201 are provided with several extension columns 210 located on one side of the corresponding mesh plate 204, and one end of each extension column 210 is provided with a limiting plate 211 for support, and the top and one side of the limiting plate 211 are provided with springs 212 installed on the mesh plate 204;

[0035] Both transparent partitions 2 are provided with access frame plates 3 on their outer sides. Access frame plates 3 are provided with outer card plates 301 for support on their outer sides. Access frame plates 3 and outer card plates 301 are provided with sliding plates 302 for blocking between them. The outer side of the transparent partition 2 and the top and bottom of the horizontal plate 203 are provided with first through holes 303 extending to one side of the access frame plate 3. Access frame plates 3, outer card plates 301 and sliding plates 302 are provided with second through holes 304 that are interconnected. Access frame plates 3 and outer card plates 301 are provided with two guide blocks 305 located on the outer side of the sliding plates 302. Guide blocks 305 are provided with guide grooves 306 that are slidably connected to the sliding plates 302.

[0036] Both transparent partition cylinders 2 are provided with protective covers 101 for partitioning at the top, and each protective cover 101 is provided with a partition plate 102 in the middle. Several second guide holes 107 are distributed on the outer side of the protective cover 101 and around the circumference of the axis of the protective cover 101. A clamping plate 103 is provided at the bottom of the partition plate 102, which is installed on the top of the transparent partition cylinder 2 and is engaged with the transparent partition cylinder 2. Several first guide holes 104 for guiding flow are distributed on the clamping plate 103 and around the circumference of the axis of the clamping plate 103. A fan 106 for heat dissipation and ventilation is provided at the bottom of the clamping plate 103. Blades 105 are provided on one side of the inner wall of the first guide hole 104.

[0037] According to the above structure, when in use, the staff installs the device at the designated location. When conducting experiments or culturing samples, the staff pulls the slide plate 302 and moves it on the guide block 305 and the storage frame plate 3 through the guide groove 306. This allows the second through hole 304 on the slide plate 302 to communicate with the second through hole 304 and the first through hole 303 on the outer card plate 301 and the storage frame plate 3. This facilitates the connection of various structures, improves the convenience of sample storage and retrieval and experiments, and enhances the ease of use.

[0038] Subsequently, the sliding plate 302 can also block the second through hole 304 on the storage frame plate 3 and the outer card plate 301 by falling under its own weight, thus preventing the sample from escaping;

[0039] Meanwhile, after the second through hole 304 and the first through hole 303 are connected, the rotating column 201 drives multiple reinforced hollow compartments 202 to rotate and move along the axis of the column 201, so that each reinforced hollow compartment 202 can be moved to the first through hole 303 one by one. This makes it easy for staff to place different samples into the corresponding reinforced hollow compartments 202 through the first through hole 303, avoiding the situation of sample information confusion.

[0040] Furthermore, when the reinforced hollow compartment 202 rotates, the reinforced hollow compartment 202 and the mesh plate 204 can be driven by the elasticity of the spring 212 itself to rotate along the axis point at the connection between the cover 206 and the limiting shaft seat 207, so that the opening of the reinforced hollow compartment 202 and the mesh plate 204 can fit tightly against the inner wall of the transparent compartment 2, avoiding the situation of the reinforced hollow compartment 202 and the mesh plate 204 becoming loose, and ensuring the isolation stability of the device during use;

[0041] Meanwhile, when the device is in use, the airflow inside the transparent partition 2 can be discharged through the first guide hole 104 and the second guide hole 107 by the operation of the fan 106, and the airflow inside the transparent partition 2 can be discharged through the mesh plate 204 for ventilation treatment when the device is in use.

[0042] Unlike existing technologies, this application discloses a rat isolator that is interconnected with the first through-hole 303 via a second through-hole 304. This facilitates the connection of various structures, improving sample access and experimental convenience, and enhancing ease of use. The sliding plate 302 can also seal the first through-hole 303 by its own weight, preventing sample escape. Each reinforced hollow compartment 202 can be moved to the first through-hole 303 one by one, allowing staff to easily place different samples into their respective reinforced hollow compartments 202 through the first through-hole 303, avoiding sample information confusion. The openings of the reinforced hollow compartments 202 and the mesh plate 204 can fit tightly against the inner wall of the transparent partition 2, preventing the reinforced hollow compartments 202 and the mesh plate 204 from becoming loose, ensuring the isolation stability of the device during use. It is convenient to use and has good practicality.

[0043] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A rodent isolator, comprising an isolation box plate (1) for support, characterized in that: An isolation assembly is provided on the isolation box plate (1); the isolation assembly includes two transparent cylinders (2) for separation provided on the isolation box plate (1), the transparent cylinders (2) are hollow in structure, and a support column (201) is provided in the middle of the transparent cylinders (2), a number of reinforced hollow compartments (202) for separation are distributed on the outside of the support column (201) and around the axis of the support column (201), and a horizontal plate (203) for separation is provided on one side of each of the multiple reinforced hollow compartments (202); an access frame plate (3) is provided on the outside of the two transparent cylinders (2), an outer card plate (301) for support is provided on the outside of the access frame plate (3), and a sliding plate (302) for blocking is provided between the access frame plate (3) and the outer card plate (301); The top of each of the two transparent partitions (2) is provided with a protective cover (101) for blocking, and a partition (102) is provided in the middle of each of the protective covers (101). A number of second guide holes (107) are distributed on the outer side of the protective cover (101) and around the axis of the protective cover (101). The bottom of the partition (102) is provided with a card plate (103) installed on the top of the transparent partition (2) and engaged with the transparent partition (2). A plurality of first guide holes (104) for guiding flow are distributed on the card plate (103) and along the circumference of the card plate (103). The top and bottom of the horizontal plate (203) are provided with a number of support poles (205), and each of the support poles (205) is provided with a mesh plate (204) for ventilation on one side.

2. The rodent isolator according to claim 1, characterized in that: The bottom of the card plate (103) is provided with a fan (106) for heat dissipation and ventilation, and a blade (105) is provided on one side of the inner wall of the first guide hole (104).

3. The rodent isolator according to claim 1, characterized in that: The top and bottom of the reinforced hollow compartment (202) are provided with clips (206) that are detachably connected to the reinforced hollow compartment (202), and one side of each clip (206) is movably connected with a limiting shaft seat (207) for support.

4. The rodent isolator according to claim 3, characterized in that: The outer side of the limiting shaft seat (207) is provided with a reinforcing frame (208) extending to the column (201), and each pair of adjacent limiting shaft seats (207) is provided with a limiting shaft (209) for limiting.

5. The rodent isolator according to claim 4, characterized in that: On the outside of the column (201) and around the circumference of the axis of the column (201), there are several extension columns (210) located on one side of the corresponding mesh plate (204), and one end of each extension column (210) is provided with a limiting plate (211) for support. The top and one side of the limiting plate (211) are provided with springs (212) installed on the mesh plate (204).

6. The rodent isolator according to claim 1, characterized in that: The transparent partition (2) has a first through hole (303) extending to one side of the access frame plate (3) on the outside of the horizontal plate (203) and at the top and bottom. The access frame plate (3), the outer card plate (301) and the slide plate (302) are all provided with a second through hole (304) that communicates with each other.

7. The rodent isolator according to claim 6, characterized in that: Two guide blocks (305) are provided between the access frame plate (3) and the outer card plate (301), both located outside the slide plate (302). The guide blocks (305) are provided with guide grooves (306) that are slidably connected to the slide plate (302).

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