A process for the recovery of 5-(n-ethyl-n-hydroxyethyl)-2-aminopentane

By adjusting the pH value and using organic solvent extraction, 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane in the wastewater from the synthesis of hydroxychloroquine sulfate was recovered, solving the pollution and waste problems of residues in the wastewater and achieving efficient resource reuse and environmental protection.

CN117820137BActive Publication Date: 2025-12-12WUHAN WUYAO PHARMA
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Patent Information

Application Number
CN202211196227.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-29
Publication Date
2025-12-12
Estimated Expiration
2042-09-29

AI Technical Summary

Technical Problem

In the existing process for synthesizing hydroxychloroquine sulfate, 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane remains in the wastewater, causing industrial pollution and waste of raw materials, and increasing production costs.

Method used

5-(N-ethyl-N-hydroxyethyl)-2-aminopentane was recovered by adjusting the pH of the wastewater to 12-14, adding organic solvent for extraction, vacuum concentration and distillation. The specific steps included adjusting the pH, adding organic solvent for extraction, vacuum concentration and distillation, using dichloromethane, toluene or ethyl acetate as solvents.

Benefits of technology

It has achieved high-purity recovery of 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane, with a purity of 98% or higher, reducing production costs and alleviating environmental pressure.

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Abstract

The application discloses a method for recycling 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane, which comprises the following steps: 1) adjusting the pH value of wastewater to 12-14 to obtain a first mixed solution; 2) adding an organic solvent to the first mixed solution for extraction to obtain an organic phase containing 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane; 3) performing vacuum concentration on the organic phase to obtain a concentrated solution; and 4) performing vacuum distillation on the concentrated solution, heating to 195-210 DEG C, and collecting a fraction at 190-200 DEG C to obtain 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane, wherein the wastewater is generated in the post-treatment stage of an amination reaction of hydroxychloroquine synthesis, and the organic solvent is at least one selected from dichloromethane, toluene and ethyl acetate. Thus, 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane in the wastewater can be recycled, the purity of the recycled substance reaches 98% or above, the recycled 5-(N-ethyl-N-hydroxyethyl)-2-aminopentane can be reused, and a large amount of production cost can be saved.
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