Arrangement device for culture apparatus for drug screening

Abstract

The present invention relates to the field of medical device storage technology, specifically to an arrangement device for a culture device for drug screening, comprising an arrangement storage box, an adaptation component, a synchronization component and a control component. A plurality of arrangement storage cavities are symmetrically opened in the arrangement storage box, and a plurality of stabilization control rollers are horizontally symmetrically provided on one side of the plurality of arrangement storage cavities. Microfluidic chips are arranged and stored by providing an arrangement storage cavity with a plurality of stabilization control rollers and a second flexible roller in the arrangement storage box, and a sealing cover with an identification plate is provided above the arrangement storage cavity to facilitate search and use by experimenters. When taking and placing the microfluidic chip, the adaptation component, the synchronization component and the control component are used to stably support and clamp the microfluidic chip according to its own size. The taking and placing operation is simple and convenient, and the arrangement storage box is provided with an ultraviolet lamp to disinfect the plurality of microfluidic chips to avoid unnecessary contamination of the microfluidic chips.

Description

Technical Field

[0001] The present invention relates to the technical field of medical device storage, in particular to an arrangement device for culture devices used for drug screening. Background Art

[0002] Microfluidic chips integrate basic operational units such as sample preparation, reaction, separation, and detection in biological, chemical, and medical analytical processes onto a single chip. Their effective structures (channels, reaction chambers, and other functional components) for accommodating fluids are micrometer-scale in at least one dimension. Due to this micrometer-scale structure, fluids exhibit and produce unique properties distinct from those at the macroscale, thus developing unique analytical capabilities. In the field of breast cancer targeted drug screening research, the combination of microfluidic chips and microplate readers has enabled biomimetic co-culture of bone and breast cancer cells and the screening of tumor drugs.

[0003] Microfluidic chips are mainly made of directly observable transparent materials such as silicon, glass, and polymer materials. Because they have micron-scale liquid channels inside, they are often sealed in independent boxes to avoid unnecessary wear and contamination during storage. However, existing microfluidic chip storage boxes have a single function. When storing chips of different sizes, special storage boxes are required. When used in places where microfluidic chips are used frequently, it is inconvenient for experimenters to take and put them, which in turn affects experimental efficiency and is inconvenient to use. Summary of the Invention

[0004] The object of the present invention is to provide an arrangement device for culture apparatus for drug screening to solve the problems raised in the above-mentioned background technology.

[0005] To achieve the above-mentioned object, the present invention provides the following technical solution: an arrangement device for a culture apparatus for drug screening, the arrangement device for a culture apparatus for drug screening comprising:

[0006] An arrangement storage box is provided with a plurality of arrangement storage cavities symmetrically formed therein, a plurality of stabilizing control rollers are symmetrically provided on one side of the plurality of arrangement storage cavities, a rotating shaft is symmetrically provided on the center of both sides of the stabilizing control rollers, a driving groove is provided on each side of the arrangement storage box close to the arrangement storage cavity, a rotating shaft on one side of the stabilizing control roller is inserted into the driving groove and sleeved with a first rotating wheel;

[0007] An adaptable assembly, the adaptable assembly comprising a plurality of adaptable shafts, the plurality of adaptable shafts being disposed on one side of the arrangement storage chamber, a second flexible roller being movably sleeved on the adaptable shaft, and a microfluidic chip being vertically disposed between the plurality of second flexible rollers and the plurality of stabilizing control rollers;

[0008] A synchronization component is disposed in the driving groove, the synchronization component includes a connecting belt, and one side of the connecting belt is connected to the plurality of first rotating wheels;

[0009] The control component is arranged on the side of the storage box close to the drive groove. The control component includes a support block, a drive pulley, a rotating shaft, a switching block and a prismatic control rod. The drive pulley is movably plugged into one side of the support block, and the drive pulley is connected to one side of the connecting belt.

[0010] Preferably, an access window is vertically opened at the upper end of the arrangement storage cavity, a sealing card slot is horizontally opened at the upper end of the access window, a sealing cover is horizontally inserted in the sealing card slot, and an identification plate is inclined at the upper end of the sealing cover.

[0011] Preferably, several of the second flexible rollers and several stabilizing control rollers are staggered, and a light trough is provided in the arrangement storage box and is horizontally connected to one side of the arrangement storage cavity. An ultraviolet lamp tube is coiled on the inner wall of the light trough, and the height inside the arrangement storage cavity is greater than the length of the microfluidic chip.

[0012] Preferably, adaptive slide grooves are horizontally opened on both sides of the adaptive shaft in the arrangement storage cavity, spring guide rods are horizontally provided in the adaptive slide grooves, and two adaptive slide grooves are respectively inserted into the two sides of the adaptive shaft and movably sleeved.

[0013] Preferably, an adaptive spring is sleeved on one side of the spring guide rod, the adaptive spring is arranged away from the microfluidic chip, and the two sides of the adaptive spring are respectively arranged to abut one side of the adaptive slide groove and the adaptive axis. The length of the second flexible roller and the stable control roller is greater than the width of the microfluidic chip, and the outer peripheral sides of the second flexible roller and the stable control roller are provided with elastic silicone anti-slip patterns.

[0014] Preferably, a plurality of rotating shafts are symmetrically provided on one side of the driving groove, a second rotating wheel is movably sleeved on one side of each rotating shaft, the second rotating wheels and the first rotating wheels are arranged in the same vertical direction, and the second rotating wheels and the first rotating wheels are spaced apart from each other.

[0015] Preferably, one side of the connecting belt is arranged around one side of the plurality of first rotating wheels and the second rotating wheels, and both sides of the connecting belt that are in contact with the first rotating wheels and the second rotating wheels are provided with anti-slip grooves.

[0016] Preferably, a bearing groove is opened in the center of the support block, a rotation groove is opened on one side of the bearing groove, the driving pulley and one side of the rotating shaft are respectively rotated and plugged into the rotation groove and the bearing groove, and the inner ring diameter of the driving pulley is larger than the diameter of the first magnetic ring.

[0017] Preferably, the inner ring of the driving pulley is provided with a spline ring, one side of the rotating shaft is provided with a prismatic structure, the switching block is sleeved on one side of the prismatic structure of the rotating shaft, a spline block is provided on one side of the switching block, the spline block of the switching block is inserted into the spline ring, and constraint rings are provided on both sides of the rotating shaft located in the prismatic structure. The two constraint rings are respectively embedded with a first magnetic ring and a second magnetic ring on one side close to the switching block, and after the spline block of the switching block is inserted into the spline ring, one side of the switching block is magnetically connected to the first magnetic ring.

[0018] Preferably, a support plate is vertically provided on one side of the arrangement storage box, a control plate is vertically provided on one side of the support plate through a bearing, a prismatic control rod is horizontally provided through the center of one side of the control plate and passes through the support plate, a prismatic groove is opened through the centers of several rotating shafts, and one side of the prismatic control rod moves horizontally through the prismatic grooves of several rotating shafts.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] The microfluidic chips are arranged and stored by arranging an arrangement storage chamber with several stable control rollers and a second flexible roller in the arrangement storage box, and a sealing cover with an identification plate is provided above the arrangement storage chamber to facilitate the experimenters to find and use. When taking and placing the microfluidic chips, the adaptation component, the synchronization component and the control component are used to stably support and clamp the microfluidic chips according to their own sizes. The taking and placing operations are simple and convenient. In addition, the arrangement storage box is equipped with an ultraviolet lamp to disinfect several microfluidic chips to avoid unnecessary contamination of the microfluidic chips. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the structure of the present invention;

[0022] Figure 2 For the present invention Figure 1 Schematic diagram of part A;

[0023] Figure 3 This is a schematic diagram of the drive slot structure of the present invention;

[0024] Figure 4 For the present invention Figure 3 Schematic diagram of part B;

[0025] Figure 5 This is a side-section schematic diagram of the arrangement of storage chamber positions in the present invention;

[0026] Figure 6 For the present invention Figure 5 Schematic diagram of the C part;

[0027] Figure 7 This is a schematic diagram of the spring guide rod connection structure of the present invention;

[0028] Figure 8 For the present invention Figure 7 Schematic diagram of the D part;

[0029] Figure 9 This is a cross-sectional view of the support block connection of the present invention;

[0030] Figure 10 For the present invention Figure 9 Schematic diagram of part E;

[0031] Figure 11 This is an exploded schematic diagram of the drive pulley control structure of the present invention.

[0032] In the figure: the storage box 1 is arranged, the storage cavity 2 is arranged, the stabilizing control roller 3, the adapting shaft 4, the second flexible roller 5, the driving groove 6, the first rotating wheel 7, the rotating shaft 8, the second rotating wheel 9, the support block 10, the driving pulley 11, the connecting belt 12, the adapting slide groove 13, the spring guide rod 14, the adapting spring 15, the inlet and outlet window 16, the sealing cover 17, the identification plate 18, the microfluidic chip 19, the ultraviolet lamp 20, the rotating shaft 21, the first magnetic ring 22, the second magnetic ring 23, the switching block 24, the spline ring 25, the prismatic groove 26, the support disk 27, the control disk 28, and the prismatic control rod 29. DETAILED DESCRIPTION

[0033] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the technical solutions in the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0034] Please see the attached Figure 1-11 , this application provides the following three preferred embodiments.

[0035] Example 1

[0036] A device for culturing a drug screening apparatus comprises: an arrangement storage box 1 symmetrically provided with a plurality of arrangement storage chambers 2; a plurality of stabilizing control rollers 3 are horizontally symmetrically provided on one side of the plurality of arrangement storage chambers 2; a rotating shaft is horizontally symmetrically provided on the centers of both sides of the stabilizing control rollers 3; a driving groove 6 is provided on each side of the arrangement storage box 1 close to the arrangement storage chamber 2; a rotating shaft on one side of the stabilizing control roller 3 is inserted into the driving groove 6 and is sleeved with a first rotating wheel 7; an adaptable component comprises a plurality of adaptable shafts 4; the plurality of adaptable shafts 4 are placed on one side of the arrangement storage chamber 2; a second flexible roller 5 is movably sleeved on the adaptable shaft 4; and a microfluidic chip 19 is vertically provided between the plurality of second flexible rollers 5 and the plurality of stabilizing control rollers 3; an inlet and outlet window 16 is vertically provided through the upper end of the arrangement storage chamber 2; a sealing card slot is horizontally provided on the upper end of the inlet and outlet window 16; a sealing cover 17 is horizontally inserted in the sealing card slot, and an identification plate 18 is tilted on the upper end of the sealing cover 17; the sealing cover 17 is elastically sleeved by the spring commonly used in the prior art The flexible parts are snap-fitted and fixed with the sealing slot, a plurality of second flexible rollers 5 and a plurality of stabilizing control rollers 3 are staggered, a lamp slot is horizontally connected to one side of the arrangement storage chamber 2 in the arrangement storage box 1, an ultraviolet lamp tube 20 is coiled on the inner wall of the lamp slot, and the height of the arrangement storage chamber 2 is greater than the length of the microfluidic chip 19, and adaptive slide grooves 13 are horizontally opened on both sides of the adaptation axis 4 in the arrangement storage chamber 2, and spring guide rods 14 are horizontally provided in the adaptation slide grooves 13, and two adaptation slide grooves 13 are respectively inserted into the two sides of the adaptation axis 4 and movably sleeved, and an adaptive spring 15 is sleeved on one side of the spring guide rod 14, and the adaptive spring 15 is arranged away from the microfluidic chip 19, and the two sides of the adaptive spring 15 are respectively abutted against one side of the adaptation slide groove 13 and the adaptation axis 4, the length of the second flexible roller 5 and the stabilizing control roller 3 is greater than the width of the microfluidic chip 19, and the outer peripheral sides of the second flexible roller 5 and the stabilizing control roller 3 are provided with elastic silicone anti-slip patterns;

[0037] When the microfluidic chip 19 needs to be stored, the sealing cover 17 is removed, and the microfluidic chip 19 is directly inserted vertically into the arrangement storage cavity 2 from the position of the access window 16. During the descent of the microfluidic chip 19, under the pushing action of the adaptation spring 15 on the adaptation shaft 4, the distance between the second flexible roller 5 and the stabilizing control roller 3 is adaptively matched with the thickness of the microfluidic chip 19, thereby realizing the stable storage of microfluidic chips 19 of multiple sizes. In addition, the self-rotating stabilizing control roller 3 and the first rotating wheel 7 with a flexible contact surface will not cause wear during the storage process of the microfluidic chip 19, and the operation is simple and convenient.

[0038] The arrangement device of a culture apparatus for drug screening disclosed in the second embodiment of the present invention has a structure that is basically the same as that in the first embodiment, except that: a plurality of stabilizing control rollers 3 are synchronously driven to rotate, so that the microfluidic chip 19 can move up and down in the arrangement storage chamber 2 and extend out of the access window 16, which is convenient for the operator to take out the microfluidic chip 19; a synchronization component is arranged in the driving groove 6, and the synchronization component includes a connecting belt 12, and one side of the connecting belt 12 is connected to a plurality of first rotating wheels 7; a plurality of rotating shafts 8 are symmetrically provided on one side of the driving groove 6, and a second rotating wheel 9 is movably sleeved on one side of the plurality of rotating shafts 8; the plurality of second rotating wheels 9 and the plurality of first rotating wheels 7 are arranged in the same vertical direction, and the plurality of The second self-rotating wheel 9 and several first self-rotating wheels 7 are arranged at intervals from each other, and one side of the connecting belt 12 is arranged in a roundabout way on one side of several first self-rotating wheels 7 and second self-rotating wheels 9, and both sides of the connecting belt 12 that are in contact with the first self-rotating wheels 7 and second self-rotating wheels 9 are provided with anti-slip grooves, and the rotation shaft 8 is arranged between the two first self-rotating wheels 7. When the connecting belt 12 passes through the first self-rotating wheel 7 and the rotation shaft 8 in a roundabout way, the connecting belt 12 moves to control the two first self-rotating wheels 7 to rotate in the same direction, and the second self-rotating wheel 9 rotates along the rotation shaft 8, and the rotation direction is opposite to that of the first self-rotating wheel 7. Under the roundabout support of the second self-rotating wheel 9, the connecting belt 12 can stably control the rotation of the first self-rotating wheel 7 and the stable control roller 3, and slipping is unlikely to occur.

[0039] The arrangement device of a culture instrument for drug screening disclosed in Example 3 of the present invention has a structure that is basically the same as that in Example 2, except that: the rotation of the stabilizing control roller 3 is driven and controlled, and the control component is arranged on the side of the arrangement storage box 1 close to the drive groove 6. The control component includes a support block 10, a drive pulley 11, a rotating shaft 21, a switching block 24 and a prismatic control rod 29. The drive pulley 11 is movably plugged into one side of the support block 10, and the drive pulley 11 is connected to one side of the connecting belt 12. A bearing groove is provided in the center of the support block 10, and a rotation groove is provided on one side of the bearing groove. The drive pulley 11 and one side of the rotating shaft 21 are respectively rotatably plugged into the rotation groove and the bearing groove, and the inner ring diameter of the drive pulley 11 is larger than the diameter of the first magnetic ring 22. The inner ring of the drive pulley 11 is provided with a spline ring 25, and one side of the rotating shaft 21 is prismatic. The structure is set up, the switching block 24 is sleeved on one side of the prismatic structure of the rotating shaft 21, and a spline block is provided on one side of the switching block 24, and the spline block of the switching block 24 is inserted into the spline ring 25. The rotating shaft 21 is located on both sides of the prismatic structure. Constraint rings are provided, and the two constraint rings are respectively embedded with a first magnetic ring 22 and a second magnetic ring 23 on one side close to the switching block 24. After the spline block of the switching block 24 is inserted into the spline ring 25, one side of the switching block 24 is magnetically connected to the first magnetic ring 22. A support plate 27 is vertically provided on one side of the storage box 1, and a control plate 28 is vertically provided on one side of the support plate 27 through a bearing. A prismatic control rod 29 is horizontally provided on one side of the control plate 28 through the support plate 27. The centers of the several rotating shafts 21 are all penetrated with prismatic grooves 26, and one side of the prismatic control rod 29 is horizontally movable through the prismatic grooves 26 of the several rotating shafts 21;

[0040] When the driving pulley 11 rotates, the driving pulley 11 drives the connecting belt 12 to circulate. At this time, the connecting belt 12 can control the rotation of the first rotating wheels 7 and the second rotating wheels 9, thereby realizing the forward and reverse rotation of the stable control roller 3, and then controlling the up and down movement of the microfluidic chip 19 through the stable control roller 3;

[0041] When the control disk 28 drives the prismatic control rod 29 to rotate, the prismatic control rod 29 simultaneously controls the plurality of rotating shafts 21 to rotate. At this time, the rotating shaft 21, under the action of the prismatic structure, drives the switching block 24 to rotate synchronously. At this time, when the spline block of the switching block 24 is away from the spline ring 25 of the driving pulley 11, the rotation of the rotating shaft 21 will not drive the driving pulley 11 to rotate. When the microfluidic chip 19 is inserted into the arrangement storage cavity 2, the stabilizing control roller 3, the second flexible roller 5 and the driving pulley 11 are in a free movable state, and the rotating shaft 21 will not affect the rotation of the driving pulley 11.

[0042] When the spline block of the switching block 24 is inserted into the spline ring 25 of the driving pulley 11, the rotating shaft 21 rotates, which can control the driving pulley 11 connected to the corresponding switching block 24 to rotate, thereby realizing the rotation of a plurality of stable control rollers 3 in a single or multiple arrangement storage chambers 2, thereby realizing the control of ejecting a microfluidic chip 19 from the arrangement storage box 1 individually, or ejecting multiple microfluidic chips 19 from the arrangement storage box 1;

[0043] When the ultraviolet lamp 20 in the arrangement storage box 1 is irradiating and sterilizing the microfluidic chip 19, the spline blocks of the plurality of switching blocks 24 can be connected to the spline rings 25 of the corresponding drive pulleys 11. At this time, the control disk 28 rotates back and forth to control the microfluidic chip 19 to move up and down in the arrangement storage chamber 2, thereby preventing the second flexible roller 5 from blocking the sterilization effect and improving the sterilization quality and efficiency.

[0044] In addition, a small hot air drying device can be connected to one side of the lamp trough, and the structure of connecting several arrangement storage cavities 2 through the lamp trough can dehumidify the several arrangement storage cavities 2 in the arrangement storage box 1 to prevent the arrangement storage box 1 from being contaminated by moisture.

[0045] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. An arrangement device for culture apparatus for drug screening, characterized in that: The arrangement device of the drug screening culture apparatus comprises: An arrangement storage box (1) is provided with a plurality of arrangement storage cavities (2) symmetrically formed therein, a plurality of stabilizing control rollers (3) are symmetrically provided on one side of the plurality of arrangement storage cavities (2), a rotating shaft is symmetrically provided on both sides of the center of the stabilizing control rollers (3), a driving groove (6) is provided on each side of the arrangement storage box (1) close to the arrangement storage cavity (2), a rotating shaft on one side of the stabilizing control rollers (3) is inserted into the driving groove (6) and is sleeved with a first rotating wheel (7); An adaptable component, the adaptable component comprising a plurality of adaptable shafts (4), the plurality of adaptable shafts (4) being disposed on one side of the arrangement storage cavity (2), a second flexible roller (5) being movably sleeved on the adaptable shaft (4), and a microfluidic chip (19) being vertically disposed between the plurality of second flexible rollers (5) and the plurality of stabilizing control rollers (3); A synchronization component is provided in the driving groove (6), the synchronization component includes a connecting belt (12), and one side of the connecting belt (12) is connected to a plurality of first rotating wheels (7); A control assembly, wherein the control assembly is arranged on a side of the arrangement storage box (1) close to the drive slot (6), and the control assembly includes a support block (10), a drive pulley (11), a rotating shaft (21), a switching block (24) and a prismatic control rod (29), wherein the drive pulley (11) is movably plugged into one side of the support block (10), and the drive pulley (11) is connected to one side of the connecting belt (12); Adaptive slide grooves (13) are horizontally provided on both sides of the adaptable shaft (4) in the arrangement storage cavity (2), and spring guide rods (14) are horizontally provided in the adaptable slide grooves (13). The two sides of the adaptable shaft (4) are respectively inserted into the two adaptable slide grooves (13) and movably sleeved in the two adaptable slide grooves (13); An adaptable spring (15) is sleeved on one side of the spring guide rod (14), and the adaptable spring (15) is arranged away from the microfluidic chip (19). Both sides of the adaptable spring (15) are respectively arranged to abut against one side of the adaptable slide groove (13) and the adaptable shaft (4). The length of the second flexible roller (5) and the stabilizing control roller (3) is greater than the width of the microfluidic chip (19), and the outer peripheral sides of the second flexible roller (5) and the stabilizing control roller (3) are provided with elastic silicone anti-slip grooves. A plurality of self-rotating shafts (8) are symmetrically arranged on one side of the driving groove (6), and a second self-rotating wheel (9) is movably sleeved on one side of each of the self-rotating shafts (8). The second self-rotating wheels (9) and the first self-rotating wheels (7) are arranged in the same vertical direction, and the second self-rotating wheels (9) and the first self-rotating wheels (7) are spaced apart from each other. One side of the connecting belt (12) is arranged on one side of the plurality of first self-rotating wheels (7) and the second self-rotating wheels (9), and both sides of the connecting belt (12) in contact with the first self-rotating wheels (7) and the second self-rotating wheels (9) are provided with anti-slip grooves.

2. The arrangement device of a culture apparatus for drug screening according to claim 1, characterized in that: An access window (16) is vertically provided at the upper end of the arrangement storage cavity (2), a sealing slot is horizontally provided at the upper end of the access window (16), a sealing cover (17) is horizontally inserted into the sealing slot, and an identification plate (18) is tilted at the upper end of the sealing cover (17).

3. The arrangement device of a culture apparatus for drug screening according to claim 2, characterized in that: A plurality of the second flexible rollers (5) and a plurality of stabilizing control rollers (3) are arranged in an interlaced manner, and a light trough is provided in the arrangement storage box (1) and is horizontally connected to one side of the arrangement storage cavity (2). An ultraviolet lamp tube (20) is wound around the inner side wall of the light trough, and the height of the arrangement storage cavity (2) is greater than the length of the microfluidic chip (19).

4. The arrangement device of a culture apparatus for drug screening according to claim 3, characterized in that: A bearing groove is provided at the center of the support block (10), a rotation groove is provided on one side of the bearing groove, and the driving pulley (11) and the rotating shaft (21) are respectively rotatably connected to the rotation groove and the bearing groove, and the inner ring diameter of the driving pulley (11) is larger than the diameter of the first magnetic ring (22).

5. The arrangement device of a culture apparatus for drug screening according to claim 4, characterized in that: The inner ring of the driving pulley (11) is provided with a spline ring (25), one side of the rotating shaft (21) is provided with a prismatic structure, the switching block (24) is sleeved on the one side of the prismatic structure of the rotating shaft (21), one side of the switching block (24) is provided with a spline block, the spline block of the switching block (24) is inserted into the spline ring (25), and the rotating shaft (21) is provided with constraint rings on both sides of the prismatic structure. The two constraint rings are respectively embedded with a first magnetic ring (22) and a second magnetic ring (23) on one side close to the switching block (24), and after the spline block of the switching block (24) is inserted into the spline ring (25), one side of the switching block (24) is magnetically connected to the first magnetic ring (22).

6. The arrangement device of a culture apparatus for drug screening according to claim 5, characterized in that: A support plate (27) is vertically provided on one side of the arrangement storage box (1), a control plate (28) is vertically provided on one side of the support plate (27) through a bearing, a prismatic control rod (29) is horizontally provided at the center of one side of the control plate (28) and passes through the support plate (27), a prismatic groove (26) is provided at the center of each of the plurality of rotating shafts (21), and one side of the prismatic control rod (29) is horizontally movable and passes through the prismatic grooves (26) of the plurality of rotating shafts (21).

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