A promoting blood circulation to remove blood stasis and moisturizing massage oil, its preparation method and application

Abstract

An embodiment of the present invention discloses a promoting blood circulation to remove blood stasis and moisturizing massage oil, its preparation method and application. A promoting blood circulation to remove blood stasis and moisturizing massage oil, the raw materials include the following components by weight: 12-18 parts of Carthamus tinctorius L., 18-22 parts of Borneol, 18-22 parts of Paeonia lactiflora Pall. var. spontanea (Rehd.) W. T. Wang, 12-18 parts of Angelica sinensis (Oliv.) Diels. The promoting blood circulation to remove blood stasis and moisturizing massage oil provided by the present invention has the effects of relieving pain and stopping bleeding, promoting blood circulation to remove blood stasis, removing necrosis and promoting granulation. It has been proved by a large number of clinical trials that it has good therapeutic effects on pressure injuries of blanching erythema, stage I, and deep tissue injury stage (without ulceration). The promoting blood circulation to remove blood stasis and moisturizing massage oil provided by the present invention has easily available raw materials, low cost, a simple and easy-to-operate preparation method, and is safe and reliable, and has good popularization and application value.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of traditional Chinese medicine, and particularly to a promoting blood circulation to remove blood stasis and moisturizing massage oil, its preparation method and application. Background Art

[0002] Pressure Ulcers, also known as bedsore, refer to a series of lesions in which the skin and soft tissues undergo ischemia, hypoxia, necrosis and inflammation due to long-term local pressure. Pressure ulcers usually occur in bony prominences, joint activity sites, areas lacking fat and muscle protection, and areas where medical devices or equipment are used and compressed. According to the depth and stage, pressure ulcers are divided into: stage 1 pressure ulcers, where the local skin is intact and there is a non-blanchable erythema; deep tissue injury stage pressure ulcers, where there is a persistent non-blanchable dark red, maroon or purple color in the intact or broken local skin, or the epidermal separation presents a black wound bed or hemorrhagic blisters. Blanchable erythema refers to the local skin being intact and showing a blanchable erythema.

[0003] Currently, for the pressure ulcers (without rupture) of blanchable erythema, stage 1 and deep tissue injury stage, the product clinically used is Acticoat from France, whose main components are peroxy corn oil (accounting for 99%) and anise (accounting for 1%). The usage method is to spray 1 - 2 drops of liquid dressing on the dangerous skin area and gently massage with fingertips for 1 minute, 6 - 7 times a day. Acticoat is relatively expensive, and for patients with long-term prevention of pressure ulcers, they need to bear a certain economic burden and there are no clinically irreplaceable related products.

[0004] Traditional Chinese herbal medicine preparations have certain advantages in protecting the skin and treating pressure ulcers, such as low cost, significant curative effect, high safety, etc. Summary of the Invention

[0005] Therefore, the embodiments of the present invention provide a promoting blood circulation to remove blood stasis and moisturizing massage oil, its preparation method and application.

[0006] In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:

[0007] According to the first aspect of the embodiments of the present invention, the present invention provides a promoting blood circulation to remove blood stasis and moisturizing massage oil, and the raw materials are composed of the following components by weight: 12 - 18 parts of Carthamus tinctorius L., 18 - 22 parts of Borneol, 18 - 22 parts of Paeonia lactiflora Pall. var. spontanea Rehd., 12 - 18 parts of Angelica sinensis (Oliv.) Diels.

[0008] Further, the raw materials are composed of the following components by weight: 15 parts of Carthamus tinctorius L., 20 parts of Borneol, 20 parts of Paeonia lactiflora Pall. var. spontanea Rehd., 15 parts of Angelica sinensis (Oliv.) Diels.

[0009] According to the second aspect of the embodiments of the present invention, the present invention provides a preparation method of the promoting blood circulation to remove blood stasis and moisturizing massage oil as described above, and the method includes:

[0010] Safflower, borneol, Paeonia lactiflora Pall. var. whittmanniana (DC.) Stern and Angelica sinensis (Oliv.) Diels are irradiated by ultraviolet rays, and then placed in a wall breaker and crushed to obtain medicinal powder.

[0011] Place the medicinal powder in a dry and airtight container, pour olive oil until the medicinal powder is completely submerged, cover the lid, seal it with plastic wrap, place the airtight container in warm water for warm soaking, filter it with gauze and then bottle it for use.

[0012] Further, the temperature of the warm soaking is 55 - 65 °C and the time is 24 hours.

[0013] According to the third aspect of the embodiments of the present invention, the present invention provides the application of the promoting blood circulation to remove blood stasis and moisturizing massage oil as described above in the preparation of products for treating white macules due to finger pressure and pressure injuries.

[0014] Further, the pressure injuries include stage 1 non - ulcerated pressure injuries and deep tissue injury stage non - ulcerated pressure injuries.

[0015] The using method of the promoting blood circulation to remove blood stasis and moisturizing massage oil of the present invention is as follows: In case of skin - related problems such as white macules due to finger pressure, stage 1 pressure injuries, and deep tissue injury stage pressure injuries (non - ulcerated), please immediately use this massage oil. Press the spray button, spray 1 - 3 drops of the massage oil on the problem skin area, gently massage with fingertips for 1 minute, use it 3 - 4 times a day on the problem area, and use this massage oil every time when changing positions or as needed.

[0016] The embodiments of the present invention have the following advantages:

[0017] The traditional Chinese medicine composition for treating white macules due to finger pressure, stage 1, and deep tissue injury stage pressure injuries (non - ulcerated) provided by the present invention: Angelica sinensis (Oliv.) Diels: The dried root of the Umbelliferae plant Angelica sinensis (Oliv.) Diels, sweet, pungent, bitter in taste, warm in nature, has the effects of enriching blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relaxing bowel movements, and is the monarch drug; Safflower, a plant of the genus Carthamus in the Compositae family, also known as Carthamus tinctorius L. and Common Safflower, the part of safflower used as medicine is the tubular florets, pungent in taste, warm in nature, belonging to the heart and liver meridians, having the effects of promoting blood circulation through the channels and dissipating stasis to relieve pain; Paeonia lactiflora Pall. var. whittmanniana (DC.) Stern, a plant of the genus Paeonia in the Ranunculaceae family in the plant kingdom, a perennial herb, the rhizome has medicinal value, belonging to the liver meridian, bitter, slightly cold, having the effects of clearing heat and detoxifying, promoting blood circulation to remove blood stasis, and detumescence and relieving pain, and the above two kinds of medicines together are the monarch drugs; Borneol, colorless transparent or white semi - transparent flaky brittle crystals, belonging to the heart, spleen, and lung meridians, pungent, bitter, slightly cold, having the effects of resuscitating the consciousness and clearing heat and relieving pain, and is the adjuvant drug. The above four kinds of medicines have the effects of clearing heat and detoxifying, detumescence and hemostasis, and promoting blood circulation to remove blood stasis. It has been proved by a large number of clinical trials that it has good therapeutic effects on white macules due to finger pressure, stage 1, and deep tissue injury stage (non - ulcerated) pressure injuries.

[0018] The raw materials of the promoting blood circulation to remove blood stasis and moisturizing massage oil provided by the present invention are easily available, with low cost. The preparation method is simple and easy to operate, and is safe and reliable, having good popularization and application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only exemplary, and for those of ordinary skill in the art, without creative efforts, other implementation drawings can also be obtained according to the provided drawings.

[0020] Figure 1 It is the process flow chart for the preparation of the promoting blood circulation to remove blood stasis and moisturizing massage oil provided by the present invention;

[0021] Figure 2 It is the comparison chart before and after using the product of the present invention for the problem area of the patient in Case 1 of the present invention;

[0022] Figure 3 It is the photo of the problem area of the patient in Case 2 of the present invention after using the product of the present invention;

[0023] Figure 4 It is the photo of the problem area of the patient in Case 3 of the present invention after using the product of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] The following specific embodiments illustrate the embodiments of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.

[0025] Example 1

[0026] This example provides a promoting blood circulation to remove blood stasis and moisturizing massage oil, and its preparation method includes:

[0027] 120 g of Carthamus tinctorius L., 220 g of Borneol, 180 g of Paeonia veitchii Lynch, and 160 g of Angelica sinensis (Oliv.) Diels are irradiated by ultraviolet rays for 30 min, then placed in a wall breaker and crushed. The obtained medicinal powder is placed in a dry and airtight container, 1950 ml of olive oil is poured in to completely immerse the medicinal powder, covered, and sealed with plastic wrap. The sealed container is placed in warm water at 60 °C, and after warm soaking for 24 hours, it is filtered with gauze and bottled for use.

[0028] Example 2

[0029] This embodiment provides a promoting blood circulation to remove blood stasis and moisturizing massage oil, and its preparation method includes:

[0030] 150 g of Carthamus tinctorius L., 200 g of Borneol, 200 g of Paeonia lactiflora Pall., and 150 g of Angelica sinensis are irradiated by ultraviolet rays for 30 min, then placed in a wall breaker and crushed. The obtained medicinal powder is placed in a dry and airtight container, 2000 ml of olive oil is poured in to completely immerse the medicinal powder, the lid is covered, and it is sealed with plastic wrap. The sealed container is placed in warm water at 60 °C, soaked for 24 hours, filtered with gauze, and then bottled for use.

[0031] Example 3

[0032] This embodiment provides a promoting blood circulation to remove blood stasis and moisturizing massage oil, and its preparation method includes:

[0033] 160 g of Carthamus tinctorius L., 220 g of Borneol, 200 g of Paeonia lactiflora Pall., and 120 g of Angelica sinensis are irradiated by ultraviolet rays for 30 min, then placed in a wall breaker and crushed. The obtained medicinal powder is placed in a dry and airtight container, 2000 ml of olive oil is poured in to completely immerse the medicinal powder, the lid is covered, and it is sealed with plastic wrap. The sealed container is placed in warm water at 60 °C, soaked for 24 hours, filtered with gauze, and then bottled for use.

[0034] Test Example 1

[0035] In order to illustrate the therapeutic effect of the traditional Chinese medicine composition of the present invention on finger pressure blanching erythema and pressure injury, the following efficacy tests were carried out for the present invention.

[0036] 1. Patient information

[0037] Twenty patients with blanching erythema on pressure and 40 patients with pressure injuries admitted to our hospital from June 2021 to June 2023 were randomly divided into Observation Groups 1 - 3 and the control group, with 15 cases in each group. In Observation Group 1, there were 6 females and 9 males, aged 60 - 80 years, with an average age of (72 ± 4.8) years and an average disease course of (13 ± 4.5) d, including 5 cases of blanching erythema on pressure, 7 cases of stage 1 pressure injury, and 3 cases of deep tissue injury stage (without ulceration) pressure injury; in Observation Group 2, there were 7 females and 8 males, aged 62 - 79 years, with an average age of (75 ± 5.5) years and an average disease course of (15 ± 3.6) d, including 6 cases of blanching erythema on pressure, 5 cases of stage 1 pressure injury, and 4 cases of deep tissue injury stage (without ulceration) pressure injury; in Observation Group 3, there were 10 females and 5 males, aged 65 - 85 years, with an average age of (78 ± 6.2) years and an average disease course of (16 ± 5.2) d, including 3 cases of blanching erythema on pressure, 10 cases of stage 1 pressure injury, and 2 cases of deep tissue injury stage (without ulceration) pressure injury; in the control group, there were 4 females and 11 males, aged 62 - 80 years, with an average age of (74 ± 4.5) years and an average disease course of (14 ± 4.2) d, including 6 cases of blanching erythema on pressure, 6 cases of stage 1 pressure injury, and 3 cases of deep tissue injury stage (without ulceration) pressure injury. There were no significant differences in the general data of the patients in each group (P > 0.05), and they were comparable.

[0038] 2. Efficacy evaluation criteria

[0039] Cured: The skin completely returns to normal, and the skin color restores to normal or forms dry crusts.

[0040] Effective: The color of the non - fading erythema becomes lighter when pressed; the area of pressure injury decreases.

[0041] Ineffective: The skin shows no change or deteriorates.

[0042] 3. Treatment methods

[0043] Observation Group 1: The promoting blood circulation to remove blood stasis and moisturizing massage oil of Example 1 was adopted, and the usage method was as follows: Press the spray button at the problem skin area, spray 1 - 3 drops of massage oil on the problem skin area, gently massage with fingertips for 1 minute, use it 3 - 4 times a day on the problem area, and use this massage oil when changing positions each time or as needed.

[0044] Observation Group 2: The promoting blood circulation to remove blood stasis and moisturizing massage oil of Example 2 was adopted, and the usage method was the same as that of Observation Group 1.

[0045] Observation Group 3: The promoting blood circulation to remove blood stasis and moisturizing massage oil of Example 3 was adopted, and the usage method was the same as that of Observation Group 1.

[0046] Control group: Algosteril was adopted, and the usage method was the same as that of Observation Group 1.

[0047] Duration of treatment: 2 weeks.

[0048] 4. Results

[0049] The comparison of clinical treatment effects of each group is shown in Table 1 below.

[0050] Table 1

[0051] Group Number of cases Cured Effective Ineffective Total effective rate Observation group 1 15 12 2 1 93.3％ Observation group 2 15 13 2 0 100％ Observation group 3 15 12 2 1 93.3％ Control group 15 12 2 1 93.3％

[0052] The results show that the blood-activating, blood-stasis-removing and moisturizing massage oil provided in the embodiments of the present invention can effectively treat pressure-induced erythema, stage 1 and deep tissue injury pressure injuries, among which Example 2 has the best effect.

[0053] Typical cases:

[0054] Case 1: Female patient, 73 years old, was admitted to the hospital with cerebral infarction by outpatient department due to speech impediment and poor appetite for 2 days. The patient was clear-headed, mentally sound, speech impediment, coughing when drinking water, poor appetite, unfavorable lower limb activities, pain in the waist and outer thigh, pain score: 2 points, poor sleep, constipation, frequent urination, red tongue, thin white greasy tongue coating, stringy pulse. Left upper limb strength 4, left lower limb strength 4-, right upper limb strength 5, right lower limb strength 5-, left limb strength without clipping. NIHSS score 2 points. Kubota drinking water test 2, Glasgow score 15 points, MRS score 4 points. The patient brought in 3.5cm×2cm deep tissue injury in the sole of the foot outside the hospital. The massage oil for promoting blood circulation and removing blood stasis and moisturizing of Example 2 was given to the patient and healed after 7 days.

[0055] Case 2: A 66-year-old male patient was admitted to our department with multiple cerebral infarctions due to poor left limb activity for 1 week and worsening for 1 day. The patient was clear-headed, mentally sound, hoarse, poor left limb activity, limited lifting, left limb muscle strength level 2, sweating, normal appetite and sleep, bowel movement once a day, a catheter was brought in from outside the hospital, yellow urine, red tongue, yellow and greasy tongue coating, normal tongue body, and stringy pulse. The patient brought in a 2×3cm 1st stage pressure injury to the sacrum and coccyx from outside the hospital. The patient was healed after 3 days of being given the blood circulation and stasis moisturizing massage oil of Example 2.

[0056] Case 3: A male patient, 83 years old, was admitted to our department by several people for cerebral infarction 13 hours after weakness of both lower limbs and speech impairment. The patient was clear-headed, weak-spirited, weak right limbs, poor mobility, limited comprehension, unable to speak, able to sleep, normal bowel movements, unable to extend tongue, and stringy and fine pulse. The patient brought in a 5×4cm erythema on the sacrum and coccyx that turned white by finger pressure from outside the hospital. The patient was cured after 1 day of the massage oil for promoting blood circulation and removing blood stasis and moisturizing in Example 2.

[0057] Although the present invention has been described in detail above with general descriptions and specific embodiments, based on the present invention, some modifications or improvements can be made, which are obvious to those skilled in the art. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A promoting blood circulation to remove blood stasis and moisturizing massage oil, characterized in that, The raw materials are composed of the following components by weight: 12-18 parts of Carthamus tinctorius L., 18-22 parts of Borneol, 18-22 parts of Paeonia lactiflora Pall. var. spontanea W. T. Wang, 12-18 parts of Angelica sinensis (Oliv.) Diels. The preparation method of the promoting blood circulation to remove blood stasis and moisturizing massage oil includes: Carthamus tinctorius L., Borneol, Paeonia lactiflora Pall. var. spontanea W. T. Wang and Angelica sinensis (Oliv.) Diels are irradiated by ultraviolet rays and then placed in a wall breaker to be crushed to obtain medicinal powder; The medicinal powder is placed in a dry and airtight container, olive oil is poured until the medicinal powder is completely immersed, the lid is covered, and it is sealed with plastic wrap. The airtight container is immersed in warm water, filtered with gauze and then bottled for use.

2. The promoting blood circulation to remove blood stasis and moisturizing massage oil according to claim 1, characterized in that The raw materials are composed of the following components by weight: 15 parts of Carthamus tinctorius L., 20 parts of Borneol, 20 parts of Paeonia lactiflora Pall. var. spontanea W. T. Wang, 15 parts of Angelica sinensis (Oliv.) Diels.

3. The promoting blood circulation to remove blood stasis and moisturizing massage oil according to claim 1, wherein The temperature of the warm immersion is 55-65 °C and the time is 24 hours.

4. Application of the promoting blood circulation to remove blood stasis and moisturizing massage oil according to claim 1 in the preparation of products for treating finger pressure blanching erythema and pressure injury.

5. The application according to claim 4, characterized in that The pressure injury includes stage 1 pressure injury and non-ulcerated pressure injury in the deep tissue injury stage.

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