A compound mosquito larvae killing composition containing cyprodinil and its application

Abstract

The invention discloses a compound mosquito larvae killing composition containing cyproflumizone and its application, comprising: 1% to 5% of active ingredients, 0% to 5% of liquid original drug adsorbent, 2% to 10% of slow-release coating agent (containing 1% to 5% of dispersant, 0.5% to 3% of wetting agent, 0.5% to 2% of binder) and the remainder carrier. The active ingredient is composed of active ingredient A and active ingredient B, active ingredient A is cyproflumizone, and active ingredient B is selected from any one of pyriproxyfen, fenthion, dimethoate, fenoxycarb, S-methoprene, dimethomorph, thiamethoxam, acetamiprid, imidacloprid, nitenpyram, cyanamide, and chlorantraniliprole. The present invention compounds active ingredient A and active ingredient B, processes them into granules, and is used for mosquito larvae control. The granules have good lethal effect, long lasting effect, slow release effect, and reduced labor costs. The granules can be widely used in sewage ditches, sewers and other places, and are particularly effective in controlling mosquito larvae.

Description

Technical Field

[0001] The invention relates to a sanitary insecticide, in particular to a compound mosquito larvae killing composition containing cyprodinil and application thereof. Background Art

[0002] Mosquitoes are the most familiar and important health pests. Mosquito control generally adopts environmental management, biological control and chemical control. Chemical control is currently the most commonly used control method. Among them, outdoor space spraying, which is commonly used to kill adult mosquitoes, can quickly reduce the density of mosquitoes. Killing larvae is also an important auxiliary measure to control mosquitoes. Outdoor stagnant water places such as abandoned tires, concrete floors, fire barrels, sewage ditches, septic tanks, rainwater wells, etc. are very easy to breed mosquito larvae. If the stagnant water cannot be removed or cannot be cleared for a while, chemical means can be used to kill the larvae.

[0003] Currently, mosquito larvae control mainly includes two categories. One is hormone products, which kill mosquitoes by inhibiting the normal molting or emergence of mosquito larvae. The other is to directly kill the larvae through contact or stomach poisoning, thereby achieving the purpose of control.

[0004] At present, the registered drugs for the control of mosquito larvae in my country are still mainly single agents, and the specific active ingredients involved include pyriproxyfen, dimethoate, fenthion, methyl pyrifos, ethomethrin, imidacloprid, Bacillus thuringiensis, Bacillus sphaericus, S-methoprene, etc., and the number of compound registrations is relatively small. The long-term use of a single agent to control mosquito larvae will inevitably make the mosquito larvae develop a certain resistance to some agents, which will greatly reduce the control effect of the agent.

[0005] Cyprosulfuron is a diamide insecticide with a novel mechanism of action and a broad insecticide spectrum. Studies have shown that cyprosulfuron has excellent control effects on lepidopteran stem borer, rice leaf roller, beet armyworm, diamondback moth, fall armyworm, coleopteran flea beetle, and some thrips, and has the characteristics of high efficiency, rapid effect, and long-lasting effect. It is safe for aquatic organisms such as fish and shrimp. There are no related reports on the control of cyprosulfuron in sanitary pests such as mosquito larvae.

[0006] At present, granules are still the main method for controlling mosquito larvae, and the preparation of granules mainly adopts carrier coating method and carrier adsorption method. The coating method is to coat the solid raw drug on the carrier to make granules, and the liquid raw drug cannot be directly coated; while the adsorption method mainly uses porous carriers to adsorb the liquid raw drug, the solid raw drug cannot be directly adsorbed, and the raw drug is simply adsorbed on the carrier, the drug is released quickly after application, and the lasting effect is poor. The present invention uses an adsorbent to adsorb the liquid raw drug, and the effective ingredient is coated on the surface of the carrier by a sustained-release coating agent, which solves the problem that the liquid raw drug cannot be coated, and has a sustained-release effect.

[0007] The present invention has found through experiments that the combination of ciprofloxacin and some insecticides has a synergistic effect on the prevention and treatment of sanitary pests mosquito larvae, which can effectively alleviate the problem of drug resistance of mosquito larvae that may be caused by long-term use of a single agent, while also improving the prevention and treatment effect, having a long lasting effect and a slow-release effect. Summary of the invention

[0008] The technical problem to be solved by the present invention is to provide a compound mosquito larvae killing composition containing ciprofloxacin and its application in view of the deficiencies in the prior art. The present invention compounds ciprofloxacin with some insecticides, wherein the active ingredients contain ciprofloxacin and active ingredient B, and the insecticidal effect is good. The dual mechanism compound has synergistic effect and is not easy to produce drug resistance.

[0009] In order to achieve the above object, the present invention adopts the following technical solution:

[0010] The present invention first provides a compound mosquito larvae killing composition containing ciprofloxacin, wherein the active ingredient is compounded from an active ingredient A and an active ingredient B, wherein the total weight of the active ingredient A and the active ingredient B accounts for 1% to 5% of the compound mosquito larvae killing composition, and the remainder is an adjuvant;

[0011] The active ingredient A is cyprodinil; the active ingredient B is selected from any one of pyriproxyfen, fenthion, dimethoate, fenoxycarb, S-methoprene, dinotefuran, thiamethoxam, acetamiprid, imidacloprid, nitenpyram, cyantraniliprole and chlorantraniliprole.

[0012] In the above technical solution, the weight ratio of the active ingredient A to the active ingredient B is 1:10 to 10:1.

[0013] In the above technical solution, the weight ratio of cyfluthrin and pyriproxyfen is 1:2 to 5:1.

[0014] In the above technical solution, the weight ratio of cyfluthrin and fenthion is 1:6 to 4:1.

[0015] In the above technical solution, the weight ratio of cyfluthrin and dinotefuran is 1:4 to 2:1.

[0016] In the above technical scheme, the auxiliary agent includes a liquid original drug adsorbent, a slow-release coating agent and a carrier; the compound mosquito larvae killing composition containing ciprofloxacin is in the form of granules; the granules, wherein the percentage of each component granule in the total weight is: 1% to 5% of the active ingredient, 0% to 5% of the liquid original drug adsorbent, 2% to 10% of the slow-release coating agent, and the carrier is supplemented to 100%.

[0017] In the above technical solution, the 2% to 10% sustained-release coating agent comprises 1% to 5% of a dispersant, 0.5% to 3% of a wetting agent, and 0.5% to 2% of a binder.

[0018] In the above technical solution, the liquid technical adsorbent is selected from any one of white carbon black, diatomaceous earth, attapulgite and bentonite.

[0019] In the above technical solution, the dispersant is selected from: sodium alkylbenzene sulfonate, sodium naphthalene sulfonate formaldehyde condensate, sodium methylene bis naphthalene sulfonate, sodium naphthalene sulfonate, sodium lignin sulfonate, and sodium polyacrylate.

[0020] In the above technical solution, the wetting agent is selected from: sodium butylnaphthalene sulfonate, sodium lauryl sulfate, sodium fatty acid ester sulfate, octylphenol polyoxyethylene ether-50, and sodium dihydroxybiphenyl sulfonate.

[0021] In the above technical solution, the binder is selected from: polyvinyl acetate, polyvinyl alcohol, sodium carboxymethyl cellulose, gum arabic, and sodium silicate.

[0022] In the above technical solution, the carrier is selected from: silica sand, quartz sand, marble, and granular calcium carbonate.

[0023] The present invention also provides a method for preparing the composite mosquito larvae killing composition containing ciprofloxacin, comprising the following steps:

[0024] (1) Mixing the dispersant, wetting agent and binder in the above weight percentages with an appropriate amount of water to prepare a sustained-release coating agent (since the water will be dried off later, there is no need to specifically limit the amount used, as long as the dispersant, wetting agent and binder can be fully dissolved);

[0025] (2) If the active ingredient B is a solid, the active ingredients A and B in the weight percentage are mixed evenly, and then mixed by air flow for later use; if the active ingredient B is a liquid, the active ingredient B in the weight percentage is adsorbed into a powder by a liquid technical adsorbent, and then mixed evenly with the active ingredient A in the weight percentage, and then mixed by air flow for later use;

[0026] (3) mixing the carrier and the sustained-release coating agent in the above weight percentage, stirring and coating, so that the sustained-release coating agent is evenly coated on the surface of the carrier; then adding the powder obtained in step (2) into the carrier coated with the sustained-release coating agent, stirring and coating evenly; finally drying the coated particles.

[0027] The present invention also provides an application of the compound mosquito larvae killing composition containing cyprodinil in killing sanitary pests in mosquito larvae breeding areas.

[0028] In the above technical solution, the sanitary pests are mosquito larvae.

[0029] In the above technical solution, the mosquito larvae breeding grounds are sewage ditches, sewers and other places.

[0030] The technical solution of the present invention has the advantages that the compound mosquito larvae killing composition of the present invention has good insecticidal effect, the dual mechanism compound has synergistic effect, and is not easy to produce drug resistance. DETAILED DESCRIPTION

[0031] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0032] Unless otherwise specified, the percentages in the following examples are by weight.

[0033] The present invention will be described below in conjunction with specific embodiments:

[0034] Formulation Example 1: 4.5% cyprodinil·pyriproxyfen granules

[0035] Cyprodinil 3%, pyriproxyfen 1.5%, sodium naphthalenesulfonate 3.5%, octylphenol polyoxyethylene ether-50 1.5%, gum arabic 1.2%, and quartz sand to 100%.

[0036] Formulation Example 2: 1% cyprodinil·pyriproxyfen granules

[0037] Cyprodinil 0.5%, pyriproxyfen 0.5%, sodium methylenebisnaphthalene sulfonate 1%, sodium fatty acid ester sulfate 0.5%, sodium carboxymethyl cellulose 0.5%, marble to 100%.

[0038] Formulation Example 3: 3% cyprodinil·fenthion granules

[0039] 0.5% cyprodinil, 2.5% fenthion, 4% sodium polyacrylate, 1% sodium dihydroxybiphenyl sulfonate, 3.5% attapulgite, 1.5% sodium silicate, and quartz sand to make up to 100%.

[0040] Formulation Example 4: 4% cyprodinil·fenthion granules

[0041] Cyprodinil 1%, fenthion 3%, sodium naphthalenesulfonate 3%, sodium butylnaphthalenesulfonate 1%, white carbon black 4%, polyvinyl alcohol 1%, and silica sand to 100%.

[0042] Formulation Example 5: 4.2% cyprodinil·dimethoate granules

[0043] Cyprodinil 0.6%, dimethoate 3.6%, sodium lignin sulfonate 5%, octylphenol polyoxyethylene ether-503%, diatomaceous earth 5%, gum arabic 2%, and granular calcium carbonate to 100%.

[0044] Formulation Example 6: 3.6% cyprodinil·dimethoate granules

[0045] Cyprodinil 2.4%, dimethoate 1.2%, sodium naphthalenesulfonate formaldehyde condensate 2.5%, sodium sulfate of fatty acid ester 1.5%, bentonite 3%, gum arabic 1.2%, granular calcium carbonate to 100%.

[0046] Formulation Example 7: 5% ciprofloxacin·fenoxycarb granules

[0047] Cyprodinil 1%, fenoxycarb 4%, sodium alkylbenzene sulfonate 4%, sodium lauryl sulfate 1%, gum arabic 1.5%, and quartz sand to 100%.

[0048] Formulation Example 8: 3% ciprofloxacin·fenoxycarb granules

[0049] Cyprodinil 1.5%, fenoxycarb 1.5%, sodium lignin sulfonate 3%, sodium lauryl sulfate 1%, sodium silicate 1%, and granular calcium carbonate are supplemented to 100%.

[0050] Formulation Example 9: 2.4% cyprodinil·S-methoprene granules

[0051] Cyprodinil 1.8%, S-methoprene 0.6%, sodium naphthalenesulfonate formaldehyde condensate 4%, octylphenol polyoxyethylene ether-50 2.5%, diatomaceous earth 3%, polyvinyl alcohol 1.5%, and quartz sand to 100%.

[0052] Formulation Example 10: 1.2% cyprodinil·S-methoprene granules

[0053] Cyprodinil 0.8%, S-methoprene 0.4%, sodium alkylbenzene sulfonate 4%, sodium dihydroxybiphenyl sulfonate 1.5%, white carbon black 1.5%, polyvinyl acetate 0.8%, granular calcium carbonate supplemented to 100%.

[0054] Formulation Example 11: 1.8% cyprodinil·dinotefuran granules

[0055] Cyprodinil 0.6%, dinotefuran 1.2%, sodium lignin sulfonate 3%, sodium butylnaphthalene sulfonate 1%, polyvinyl acetate 1%, and silica sand to 100%.

[0056] Formulation Example 12: 4.2% cyprodinil·dinotefuran granules

[0057] Cyprodinil 2.8%, dinotefuran 1.4%, sodium naphthalenesulfonate formaldehyde condensate 2.5%, sodium butylnaphthalenesulfonate 1%, gum arabic 1.8%, and quartz sand to 100%.

[0058] Formulation Example 13: 3.3% cyprodinil·thiamethoxam granules

[0059] Cyprodinil 1.1%, thiamethoxam 2.2%, sodium methylenebisnaphthalene sulfonate 1.5%, sodium sulfate of fatty acid ester 1%, sodium silicate 2%, granular calcium carbonate supplemented to 100%.

[0060] Formulation Example 14: 4.4% cyprodinil·thiamethoxam granules

[0061] Cyprodinil 2.2%, thiamethoxam 2.2%, sodium lignin sulfonate 5%, sodium dihydroxybiphenyl sulfonate 3%, sodium silicate 1.5%, granular calcium carbonate supplemented to 100%.

[0062] Formulation Example 15: 4% cyprodinil-acetamiprid granules

[0063] Cyprodinil 2%, acetamiprid 2%, sodium methylenebisnaphthalene sulfonate 5%, sodium fatty acid ester sulfate 2%, sodium carboxymethyl cellulose 2%, and granular calcium carbonate supplemented to 100%.

[0064] Formulation Example 16: 2.8% cyprodinil·acetamiprid granules

[0065] Cyprodinil 0.7%, acetamiprid 2.1%, sodium naphthalenesulfonate 4%, sodium lauryl sulfate 1%, polyvinyl acetate 1.3%, marble made up to 100%.

[0066] Formulation Example 17: 2.2% cyprodinil·imidacloprid granules

[0067] Cyprodinil 0.6%, imidacloprid 1.8%, sodium alkylbenzene sulfonate 2.5%, octylphenol polyoxyethylene ether-50 1.5%, bentonite 4%, polyvinyl alcohol 0.5%, granular calcium carbonate supplemented to 100%.

[0068] Formulation Example 18: 2.5% cyprodinil·imidacloprid granules

[0069] Cyprodinil 2%, imidacloprid 0.5%, sodium polyacrylate 3.5%, sodium lauryl sulfate 0.6%, gum arabic 1.2%, and silica sand to 100%.

[0070] Formulation Example 19: 3.2% cyprodinil·nitenpyram granules

[0071] Cyprodinil 0.8%, nitenpyram 2.4%, sodium lignin sulfonate 4.5%, sodium dihydroxybiphenyl sulfonate 1%, polyvinyl alcohol 1.2%, marble made up to 100%.

[0072] Formulation Example 20: 1.2% cyprodinil·nitenpyram granules

[0073] Cyprodinil 0.8%, nitenpyram 0.4%, sodium polyacrylate 3%, sodium dihydroxybiphenyl sulfonate 1%, sodium silicate 1%, marble made up to 100%.

[0074] Formulation Example 21: 3.6% cyfluthrin-cyanamide granules

[0075] Cyprodinil 2.7%, cyantraniliprole 0.9%, sodium alkylbenzene sulfonate 4%, sodium sulfate of fatty acid ester 1.5%, sodium carboxymethyl cellulose 1.5%, and silica sand to 100%.

[0076] Formulation Example 22: 3% cyfluthrin-cyanamide granules

[0077] Cyprodinil 1%, cyantraniliprole 2%, sodium lignin sulfonate 4%, sodium butylnaphthalene sulfonate 2%, sodium carboxymethyl cellulose 1.5%, and quartz sand to 100%.

[0078] Formulation Example 23: 4.2% cyprodinil·chlorfenapyr granules

[0079] Cyprodinil 2.8%, chlorfenapyr 1.4%, sodium polyacrylate 5%, sodium lauryl sulfate 2%, sodium carboxymethyl cellulose 2%, and quartz sand to 100%.

[0080] Formulation Example 24: 1.5% cyfluthrin-chlorfenapyr granules

[0081] Cyprodinil 0.5%, chlorfenapyr 1%, sodium alkylbenzene sulfonate 1.5%, octylphenol polyoxyethylene ether-50 0.5%, polyvinyl acetate 0.5%, marble supplemented to 100%.

[0082] Application Example 1: Efficacy test for controlling mosquito larvae

[0083] Test target: Late third and early fourth instar larvae of Culex pipiens pallens

[0084] Test method: Add 5L of dechlorinated water to a plastic bucket, weigh the granules and put them into the water to make the active ingredient concentration 1mg / L. After one day, measure 200mL of the water with medicine into a 250mL beaker and put 30 Culex pipiens pallens larvae. The test insects are raised under the experimental conditions of (25±1)℃ and relative humidity (60±10)%, and repeated three times. The number of deaths is counted after 7 days. The larvae are considered dead if they do not move or just tremble when gently touched with the tip of tweezers. Larvae that have already pupated but do not move or just tremble when gently touched with the tip of tweezers are also considered dead.

[0085] Test treatment: Formulation examples 1, 3, 7, 9, 11, and 21 were used to treat water bodies with a total active ingredient concentration of 1 mg / L;

[0086] Control sample 1: 5% cyprodinil granules (prepared according to the method of Formulation Example 1) diluted to 1 mg / L;

[0087] Control sample 2: 5% pyriproxyfen granules (prepared according to the method of Formulation Example 1 of the present invention) diluted to 1 mg / L;

[0088] Control sample 3: 5% fenthion granules (prepared according to the method of Formulation Example 3 of the present invention) diluted to 1 mg / L;

[0089] Control sample 4: 5% fenoxycarb granules (prepared according to the method of formulation example 7 of the present invention) diluted to 1 mg / L;

[0090] Control sample 5: 5% S-methoprene granules (prepared according to the method of Formulation Example 9 of the present invention) diluted to 1 mg / L;

[0091] Control sample 6: 5% dinotefuran granules (prepared according to the method of Formulation Example 11 of the present invention) diluted to 1 mg / L;

[0092] Control sample 7: 5% cyantraniliprole granules (prepared according to the method of Formulation Example 21 of the present invention) diluted to 1 mg / L;

[0093] Blank control: 200 mL dechlorinated water

[0094] The test results show that the lethality of the control samples 1-7 to mosquito larvae is lower than that of the preparation of the present invention, and the lethality of the preparation examples 1, 3, 7, 9, 11, and 21 of the present invention to mosquito larvae is good. (See Table 1)

[0095] Table 1 Efficacy test of formulation examples 1, 3, 7, 9, 11, 21 for controlling mosquito larvae

[0096] deal with Fatality rate (%) Preparation Example 1 97.8 Formulation Example 3 98.9 Formulation Example 7 97.8 Preparation Example 9 98.9 Preparation Example 11 100 Preparation Example 21 100 Control sample 1 92.2 Control sample 2 87.8 Control sample 3 88.9 Control sample 4 86.7 Control sample 5 87.8 Control sample 6 86.7 Control sample 7 85.6 Blank control /

[0097] The remaining preparation examples were further subjected to the same efficacy test, and the lethal effect was good.

[0098] Application Example 2: Sustained-release and sustained-effect test for controlling mosquito larvae

[0099] Test target: Late third and early fourth instar larvae of Culex pipiens pallens

[0100] Test method: Add 5L of dechlorinated water into a plastic bucket, weigh the granules and put them into the water to make the active ingredient concentration 1mg / L. After leaving it for 1 day, measure 200mL of the medicated water into a 250mL beaker; put 30 Culex pipiens larvae into the beaker. The test insects are raised under the experimental conditions of (25±1)℃ and relative humidity (60±10)%. Repeat three times. Count the number of deaths after 7 days. Touch the larvae lightly with the tip of tweezers. If they do not move or just tremble, they are considered dead. Larvae that have already pupated but do not move or just tremble when touched lightly with the tip of tweezers are also considered dead. On the 14th day, pour out the water from the plastic bucket containing the medicine, leaving the granules, add fresh dechlorinated water, let it stand for 1 day, then measure 200mL of the medicine-containing water into a 250mL beaker, and conduct the same efficacy test. Similarly, pour out the water on the 29th day, add fresh dechlorinated water, let it stand for 1 day, then measure 200mL of the medicine-containing water into a 250mL beaker, and conduct the efficacy test.

[0101] Preparation of control sample: The preparation method of the control sample of this test is as follows: a certain amount of solvent is used to dissolve the solid technical drug, and a porous carrier (volcanic rock particles) is used to absorb the solution containing the solid technical drug and the liquid technical drug. After sufficient mixing, stirring and absorption, the granules are completely prepared.

[0102] Test treatment: Formulation examples 2, 5, 8, 10, 13, and 23 were used to treat water bodies with a total active ingredient concentration of 1 mg / L;

[0103] Control sample 8: Granules of the same concentration as in Preparation Example 2 (prepared by porous carrier adsorption method) diluted to 1 mg / L;

[0104] Control sample 9: granules of the same concentration as in Example 5 (prepared by porous carrier adsorption method) diluted to 1 mg / L;

[0105] Control sample 10: granules of the same concentration as in Preparation Example 8 (prepared by porous carrier adsorption method) diluted to 1 mg / L;

[0106] Control sample 11: granules of the same concentration as in Preparation Example 10 (prepared by porous carrier adsorption method) diluted to 1 mg / L;

[0107] Control sample 12: granules of the same concentration as in Preparation Example 13 (prepared by porous carrier adsorption method) diluted to 1 mg / L;

[0108] Control sample 13: granules of the same concentration as in Preparation Example 23 (prepared by porous carrier adsorption method) diluted to 1 mg / L;

[0109] Test results:

[0110] The test results show that the preparation of the present invention has a good lethality on the 1st day, the 15th day and the 30th day during the effective period, and has a sustained release effect. The lethality on the 15th day and the 30th day is better than that of the control sample 8-13 to mosquito larvae. The control sample 8-13 has a good lethality on the 1st day, but due to the use of a simple porous carrier for adsorption, the release rate of the effective ingredient is fast, and the lethality on the 15th day and the 30th day is poor; the preparation examples 2, 5, 8, 10, 13, and 23 of the present invention have good lethality, good persistence, and a sustained release effect (see Table 2)

[0111] Table 2 Sustained release and sustained effect test of formulation examples 2, 5, 8, 10, 13, 23 for controlling mosquito larvae

[0112]

[0113]

[0114]

[0115] The remaining formulation examples were further subjected to the same efficacy test, and the lethal effect was good and the lasting effect was good.

[0116] Application Example 3: Outdoor efficacy test on breeding ground mosquito larvae

[0117] Target: Mosquito larvae

[0118] Test method: Sprinkle the pesticide in the sewage ditch and record the decrease rate of mosquito larvae density in 24 hours;

[0119] Test treatment: Formulation examples 4, 15, 17, 19, 22 were spread at a rate of 2 g / m 2 ;

[0120] Test results:

[0121] The test results show that the preparation of the present invention has a significant effect in killing mosquito larvae, and the density reduction rate of mosquito larvae is high (see Table 3).

[0122] Table 3 Outdoor efficacy test on breeding ground mosquito larvae

[0123] deal with Density reduction rate (%) Formulation Example 4 98.3 Preparation Example 15 96.7 Preparation Example 17 97.1 Formulation Example 19 97.9 Preparation Example 22 96.7

[0124] Application Example 4: Determination of the co-toxicity coefficient of cyfluthrin and other active ingredients to mosquito larvae

[0125] Test target: Late third and early fourth instar larvae of Culex pipiens pallens

[0126] Test method: Dilute the agent with acetone to 5 to 7 concentration gradients, draw 1 mL and add it to a beaker containing 149 mL of dechlorinated water, stir evenly, and repeat three times. Then draw 30 Culex pipiens pallens together with 50 mL of dechlorinated water and add them to the above water body, a total of 200 mL of water body for testing. The test insects are raised under the experimental conditions of (25±1)℃ and relative humidity (60±10)%. The number of deaths is counted after 24 hours. The larvae are gently touched with the tip of tweezers. If they do not move or just tremble, they are considered dead. If the larvae have already pupated, but they do not move or just tremble when gently touched with the tip of tweezers, they are also considered dead.

[0127] The data were used to calculate the median lethal concentration (LC50) using the linear weighted regression method, and the co-toxicity coefficient was calculated with reference to Sun Yunpei's method.

[0128] The test results show that, through indoor efficacy tests and calculations, the insecticidal composition of the present invention has a good synergistic effect on the lethality of mosquito larvae after compounding. The specific results are shown in the following table:

[0129] Table 4 Determination of the co-toxicity coefficient of cyprodinil and pyriproxyfen (for Culex pipiens larvae)

[0130]

[0131] As shown in Table 4, when the combination ratio of ciprofloxacin and pyriproxyfen was 1:7-7:1, the co-toxicity coefficient against mosquito larvae was greater than 100, especially when the combination ratio was 1:2-5:1, the co-toxicity coefficient exceeded 120, showing a significant synergistic effect.

[0132] Table 5 Determination of the co-toxicity coefficient of cyprodinil and fenthion (for Culex pipiens larvae)

[0133]

[0134]

[0135] As shown in Table 5, when the combination ratio of ciprofloxacin and fenthion was 1:8-8:1, the co-toxicity coefficient against mosquito larvae was greater than 100, especially when the combination ratio was 1:6-4:1, the co-toxicity coefficient exceeded 120, showing a significant synergistic effect.

[0136] Table 6 Determination of the co-toxicity coefficient of cyprodinil and dinotefuran (for Culex pipiens pallens larvae)

[0137]

[0138] As shown in Table 6, when the combination ratio of ciprofloxacin and dinotefuran was 1:8-6:1, the co-toxicity coefficient against mosquito larvae was greater than 100, especially when the combination ratio was 1:4-2:1, the co-toxicity coefficient exceeded 120, showing a significant synergistic effect.

[0139] Table 7 Optimal co-toxicity coefficient of cyprodinil and other active ingredients B (for Culex pipiens larvae)

[0140]

[0141]

[0142] As can be seen from Table 7, the optimal ratio of ciprofloxacin combined with other active ingredients B has a co-toxicity coefficient of more than 120, and the synergistic effect is obvious.

[0143] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A composite mosquito larvae killing composition containing ciprofloxacin, characterized in that: The active ingredient is compounded by active ingredient A and active ingredient B, and the total weight of active ingredient A and active ingredient B accounts for 1% to 5% of the compound mosquito larvae killing composition by weight, and the balance is adjuvant; The active ingredient A is cyprodinil; the active ingredient B is pyriproxyfen; and the weight ratio of the active ingredient A to the active ingredient B is 1:2 to 5:

1.

2. The composite mosquito larvae killing composition according to claim 1, characterized in that: The auxiliary agent comprises a liquid original drug adsorbent, a slow-release coating agent and a carrier; the compound mosquito larvae killing composition containing ciprofloxacin is in the form of a granule; the granule, wherein the percentage of each component granule in the total weight is: 1% to 5% of the active ingredient, 0% to 5% of the liquid original drug adsorbent, 2% to 10% of the slow-release coating agent, and the carrier is supplemented to 100%.

3. The composite mosquito larvae killing composition according to claim 2, characterized in that: The 2% to 10% sustained-release coating agent comprises 1% to 5% of a dispersant, 0.5% to 3% of a wetting agent, and 0.5% to 2% of a binder.

4. The composite mosquito larvae killing composition according to claim 2, characterized in that: The liquid technical adsorbent is selected from any one of white carbon black, diatomaceous earth, attapulgite and bentonite; the carrier is selected from one of silica sand, quartz sand, marble and granular calcium carbonate.

5. The composite mosquito larvae killing composition according to claim 3, characterized in that: The dispersant is selected from the group consisting of sodium alkylbenzene sulfonate, sodium naphthalene sulfonate formaldehyde condensate, sodium methylene bis-naphthalene sulfonate, sodium naphthalene sulfonate, sodium lignin sulfonate, and sodium polyacrylate; the wetting agent is selected from the group consisting of sodium butyl naphthalene sulfonate, sodium lauryl sulfate, sodium fatty acid ester sulfate, octylphenol polyoxyethylene ether-50, and sodium dihydroxybiphenyl sulfonate; the binder is selected from the group consisting of polyvinyl acetate, polyvinyl alcohol, sodium carboxymethyl cellulose, gum arabic, and sodium silicate.

6. Use of the composite mosquito larvicidal composition containing cyprodinil as claimed in claim 1 in killing sanitary pests in mosquito larvae breeding areas, characterized in that: The sanitary pests are mosquito larvae; the breeding grounds of the mosquito larvae are sewage ditches and sewers.

Images