A traditional Chinese medicine oil and its preparation method and application

Abstract

The invention discloses a traditional Chinese medicine oil, a preparation method, and an application thereof, belonging to the technical field of traditional Chinese medicine. The raw materials of the traditional Chinese medicine oil, measured by mass, include: 60-65 parts of frankincense, 60-65 parts of myrrh, 55-65 parts of red peony root, 30-40 parts of lithospermum officinale, 15-25 parts of angelica dahurica, 10-15 parts of rhubarb, 10-15 parts of sanguisorba officinalis, 12-15 parts of dragon's blood, 10-15 parts of calcined pearl powder, 10-15 parts of catechu, 36-42 parts of liquorice, 90-120 parts of white beeswax, 15-30 parts of honeysuckle, and 500-550 parts of sesame oil. Clinical verification shows that the Chinese medicinal oil gauze prepared from the Chinese medicinal oil of the present invention has good therapeutic effects on bedsores, diabetic foot, postoperative wounds that do not heal, varicose ulcers of the lower limbs, tuberculous ulcers, arterial ulcers, cancerous ulcers, radiation ulcers, inflammatory ulcers, and chronic skin ulcers with fistulas and sinus tracts, with a total effective rate of over 95%.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine oil and a preparation method and application thereof. Background Art

[0002] Chronic skin ulcers (CSU) are wounds that persist for more than one month without significant healing or that frequently recur. Due to their persistent nature and high recurrence rate after healing, CSU is a common and complex skin disease in clinical practice. Western medicine primarily uses anti-inflammatory drugs, debridement, and skin grafting as treatment options, but these treatments are long, expensive, and can even lead to cancer. CSU places a significant burden on patients and their families, and carries a high disability rate. Clinical treatment is challenging and remains a significant challenge.

[0003] Traditional Chinese medicine usually classifies CSU as "sores and ulcers", and recognized and treated it early, and gradually formed unique treatment principles and methods. Summary of the Invention

[0004] The present invention aims to provide a Chinese medicine oil and its preparation method and application. The present invention improves upon the experience of predecessors and develops an empirical formula for treating CSU with analgesic and myogenic oil gauze, which has significant clinical effects, low price, and no obvious toxic and side effects.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] One of the technical solutions of the present invention is to provide a traditional Chinese medicine oil. The raw materials, calculated by weight, include: 60-65 parts of frankincense, 60-65 parts of myrrh, 55-65 parts of red peony root, 30-40 parts of lithospermum erythrorhizon, 15-25 parts of angelica dahurica, 10-15 parts of rhubarb, 10-15 parts of sanguisorba officinalis, 12-15 parts of dragon's blood, 10-15 parts of calcined pearl powder, 10-15 parts of catechu, 36-42 parts of liquorice, 90-120 parts of white beeswax, 15-30 parts of honeysuckle and 500-550 parts of sesame oil.

[0007] Preferably, the composition comprises 60 parts of frankincense, 60 parts of myrrh, 50 parts of red peony root, 30 parts of lithospermum officinale, 15 parts of angelica dahurica, 12 parts of dragon's blood, 10 parts of rhubarb, 10 parts of calcined pearl powder, 10 parts of raw sanguisorba officinalis, 10 parts of catechu, 36 parts of liquorice, 90 parts of white beeswax, 15 parts of honeysuckle and 500 parts of sesame oil.

[0008] The second technical solution of the present invention is to provide a method for preparing the above-mentioned Chinese medicine oil, comprising the following steps:

[0009] Add frankincense, myrrh, red peony root, rhubarb, lithospermum officinale, angelica dahurica, raw sanguisorba officinalis, licorice and catechu to the sesame oil and soak, then heat until the angelica dahurica and licorice are black on the outside and yellow on the inside, stop heating, immediately add honeysuckle, and filter out all the drugs after 30s-60s; melt white beeswax and add it to the above medicinal oil, heat until fully blended, cool, and when the temperature drops to 80-90℃, add dragon's blood powder and calcined pearl powder, stir evenly, and filter to obtain the final Chinese medicinal oil.

[0010] Preferably, the soaking temperature is 20-25° C. and the soaking time is 3-5 days.

[0011] Preferably, when the angelica dahurica and liquorice are heated until they are black on the outside and yellow on the inside, the heating temperature is 180-200°C.

[0012] The third technical solution of the present invention is to provide a Chinese medicine oil gauze, the active ingredient of which is the above-mentioned Chinese medicine oil.

[0013] The fourth technical solution of the present invention is to provide a method for preparing the above-mentioned Chinese medicine oil gauze, comprising the following steps: soaking sterile gauze with Chinese medicine oil and sterilizing it to obtain the Chinese medicine oil gauze.

[0014] The fifth technical solution of the present invention: provides an application of the above-mentioned traditional Chinese medicine oil in the preparation of a preparation for treating chronic skin ulcers.

[0015] Technical solution six of the present invention: provides an application of the above-mentioned traditional Chinese medicine oil gauze in the preparation of a preparation for treating chronic skin ulcers.

[0016] The beneficial technical effects of the present invention are as follows:

[0017] In the Chinese medicinal oil of the present invention, frankincense and myrrh are reused as the main medicines. This pair of medicines is also the fine product of this prescription. Frankincense has a pungent and bitter flavor and is warm in nature. The pungent fragrance can move qi and relieve stagnation, activate blood circulation and eliminate blood stasis, and promote the growth of new flesh by removing blood stasis. Myrrh has a bitter and pungent taste and is neutral in nature. It can disperse blood and eliminate blood stasis, reduce swelling and relieve pain. Frankincense is mainly effective in promoting blood circulation, while myrrh is partial in dispersing blood. The combination of frankincense and myrrh has stronger analgesic, swelling-reducing and muscle-building effects.

[0018] The ministerial herbs are red peony root and raw sanguisorba officinalis. Among them, red peony root is bitter in taste and slightly cold in nature. It can dissipate and promote circulation, clear away heat and cool blood, disperse blood stasis and relieve pain. It specifically enters the blood and has the functions of promoting blood circulation, removing blood stasis and relieving pain. Raw sanguisorba officinalis is bitter and sour in taste, cold in nature, non-toxic, and enters the liver, lung, kidney and large intestine meridians. It has the functions of clearing heat and cooling blood, detoxifying and reducing swelling, and astringing sores and relieving pain.

[0019] The assistant herbs include Angelica dahurica and Sanguisorba officinalis. Angelica dahurica has a pungent and fragrant smell, dissipates stagnation, relieves pain by entering blood, nourishes the skin, and is fragrant and pungent, moisturizing. Its texture is smooth and lubricating, and it can harmonize and benefit the blood vessels, dispel wind, and erode pus. It has a strong warming effect, and can open the orifices and move the surface. It is the main herb for dispelling wind and dampness in the Foot Yangming Meridian, and has the effects of dispersing wind and dampness, opening the orifices and relieving pain, and reducing swelling and discharging pus. Sanguisorba officinalis has a sweet and salty taste and is neutral in nature. It can promote blood circulation, dissipate blood stasis, relieve pain, stop bleeding, promote tissue regeneration, and heal sores. It is a key herb for dispersing blood stasis and generating new blood. The above four herbs together enhance the effects of the main herb in promoting blood circulation, relieving pain, discharging pus, and heal sores.

[0020] The adjuvants are lithospermum, honeysuckle, rhubarb, catechu, and calcined pearl powder to enhance the effects of clearing heat and detoxifying, astringing sores and relieving pain; among them, catechu tastes bitter and astringent, is neutral in nature, clears heat and removes dampness, astringes sores and promotes tissue regeneration, stops bleeding and relieves pain; honeysuckle is cold in nature and sweet in taste, has the effects of clearing heat and detoxifying, anti-inflammatory, tonifying deficiency and treating wind, and is mainly used to treat bloating, fever due to febrile diseases, carbuncles and tumors caused by heat toxins, and has been praised as a good medicine for clearing heat and detoxifying since ancient times; rhubarb tastes slightly bitter and is cold in nature, and enters the stomach, large intestine, liver, and spleen meridians, and has the effects of guiding blood stasis, breaking up tumors, dispersing hard masses, relieving pain, defeating carbuncle heat toxins, and reducing swelling; lithospermum is sweet and salty in taste, is cold in nature, cools blood and promotes blood circulation, clears heat and detoxifies; calcined pearl powder is sweet and salty in taste, is cold in nature, clears heat and detoxifies, promotes tissue regeneration, astringes sores, resolves knots and toxins, transforms malignant sores, and shrinks internal ulcers.

[0021] The ingredients are licorice, beeswax, and sesame oil. Licorice is sweet and neutral in nature, clearing away heat and detoxifying, relieving urgency and relieving pain, and harmonizing the other ingredients. White beeswax is sweet and slightly warm in nature, promoting tissue regeneration, stopping bleeding, relieving pain, replenishing deficiency, strengthening tendons and bones, warming the meridians and unblocking collaterals, relieving pain and promoting tissue regeneration, and healing sores. Sesame oil is sweet and cold in nature, and has the power to clear heat, detoxify, cool blood, relieve pain, reduce swelling, and promote tissue regeneration. Therefore, this prescription focuses on relieving pain and promoting tissue regeneration. The combination of these ingredients can achieve the effects of detoxification, reducing swelling, promoting tissue regeneration, and relieving pain.

[0022] Clinical trials have shown that the Chinese medicinal oil gauze prepared by the present invention has good therapeutic effects on bedsores, diabetic foot, non-healing postoperative wounds, varicose ulcers of the lower limbs, tuberculous ulcers, arterial ulcers, cancerous ulcers, radiation ulcers, inflammatory ulcers, and chronic skin ulcers with fistulas and sinus tracts, with a total effective rate of over 95%. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 The following are the changes in the wound of a typical case before and after medication, where A to F represent the changes in the wound respectively.

[0024] Figure 2 This is a diagram of the wound changes before and after medication in typical case 2, where A to I represent the wound changes respectively.

[0025] Figure 3 The following are the changes in the wound before and after medication in typical case three, where A to F represent the changes in the wound respectively.

[0026] Figure 4The following are the changes in the wound before and after medication in typical case 4, where A to F represent the changes in the wound respectively.

[0027] Figure 5 The following are the changes in the wound before and after medication in typical case 5, where A to F represent the changes in the wound respectively.

[0028] Figure 6 The following are the changes in the wound before and after medication in typical case 6, where A to E represent the changes in the wound respectively.

[0029] Figure 7 The following are the changes in the wound of typical case 7 before and after medication, among which A to F are the changes in the wound respectively.

[0030] Figure 8 The following are the changes in the wound before and after medication in typical case 8, where A to F represent the changes in the wound respectively.

[0031] Figure 9 The following are the changes in the wound before and after medication in typical case 9, where A to F represent the changes in the wound respectively.

[0032] Figure 10 The following is a diagram showing the changes in the wound before and after medication in typical case nine, where A to D represent the changes in the wound respectively.

[0033] Figure 11 The following are the changes in the wound of a typical case before and after medication, where A to D represent the changes in the wound respectively.

[0034] Figure 12 The following are the changes in the wound of a typical case before and after medication, where A to D represent the changes in the wound respectively.

[0035] Figure 13 The following is a diagram showing the changes in the wound before and after medication in a typical case 11, where A to F represent the changes in the wound respectively. DETAILED DESCRIPTION

[0036] Various exemplary embodiments of the present invention are now described in detail. This detailed description should not be considered as a limitation of the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention. It should be understood that the terms used in the present invention are only for describing specific embodiments and are not intended to limit the present invention.

[0037] In addition, for numerical ranges in the present invention, it is understood that each intervening value between the upper and lower limits of the range is also specifically disclosed. Each smaller range between any stated value or stated range, and any other stated value or intervening value in the stated range, is also included in the present invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.

[0038] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Although preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention.

[0039] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0040] Example 1

[0041] Preparation of Chinese medicine oil gauze:

[0042] (1) Prepare the following ingredients: 60 parts of frankincense, 60 parts of myrrh, 50 parts of red peony root, 30 parts of lithospermum officinale, 15 parts of angelica dahurica, 12 parts of dragon's blood, 10 parts of rhubarb, 10 parts of calcined pearl powder, 10 parts of raw sanguisorba officinalis, 10 parts of catechu, 36 parts of liquorice, 90 parts of white beeswax, 15 parts of honeysuckle and 500 parts of sesame oil.

[0043] (2) Add frankincense, myrrh, red peony root, rhubarb, lithospermum officinale, angelica dahurica, raw sanguisorba officinalis, licorice and catechu to the sesame oil and soak at 20℃ for 3 days;

[0044] (3) Deep-fry all the herbs soaked in sesame oil at 200°C until the angelica and licorice are black on the outside and yellow on the inside. After turning off the heat, add honeysuckle immediately. After 1 minute, filter out all the herbs and set aside.

[0045] (4) Heat and melt white beeswax separately. After it is completely melted, add it to the above oil, heat it again until it is fully dissolved, and then cool it. When the temperature drops to 80-90°C, add the dragon's blood powder and calcined pearl powder in a clockwise direction, stir thoroughly, filter, remove the residue, and cool.

[0046] (5) After the temperature of the mixed drug oil drops to 50°C, pour it into a sterile box filled with sterile gauze. Each piece of sterile gauze is 9*7cm and 8 layers thick. The sterile gauze is evenly stacked in the sterile box. The amount of drug oil poured in should be sufficient to fully penetrate the sterile gauze and exceed 5mm. Finally, cover and sterilize under high pressure for later use.

[0047] Effect verification:

[0048] 1. General Information:

[0049] A total of 300 patients with chronic skin ulcers who visited the First Hospital of Shanxi Medical University were selected, including 100 patients with bedsores (pressure sores), 100 patients with venous ulcers (ecthyma), and 100 patients with postoperative wound failure.

[0050] 2. Diagnostic criteria:

[0051] (1) Bed sores: According to the Traditional Chinese Medicine Industry Standard of the People’s Republic of China, “Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases”.

[0052] It is common in areas where bony protrusions such as the sacrum, spine, elbows and ankles are prone to compression and friction; initially, brown erythema and slight swelling appear on the skin, followed by dark purple edema, necrosis and ulceration; when secondary infection occurs, tissue necrosis occurs rapidly, pus oozes, and gluteal pain occurs in the corresponding areas; it is more common in patients who are bedridden for a long time due to coma, paralysis, fractures, large-area burns, etc.

[0053] According to the American Pressure Ulcer Association, pressure ulcers are divided into four stages:

[0054] Stage I is the bruise and redness stage, which is the early stage of pressure sores and refers to the red spots that do not fade when pressed and appear in the same area for two consecutive observation days;

[0055] Stage II is the inflammatory infiltration stage, which means that the epidermis and / or dermis are damaged, and the ulcer is superficial, manifested as skin damage, blisters or shallow crater-like ulcers;

[0056] Stage III is the superficial ulcer stage, which refers to ulceration or necrosis of subcutaneous tissue, which may invade the deep fascia. Stage I clinically manifests as a deep crater-like ulcer with or without damage to adjacent tissues.

[0057] Stage IV is the necrotic ulcer stage, which is the severe stage of pressure sores. It means that the deep tissue is destroyed and can reach the muscle layer, bones or their supporting structures (such as tendons and joint capsules).

[0058] (2) Venous ulcer: According to the Traditional Chinese Medicine Industry Standard of the People's Republic of China "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases".

[0059] It is more common on the medial side of the lower leg; the local area is often itchy at first and then painful, with redness and erosion, and quickly turns into ulcers; the ulcers vary in size, are grayish white or dark red, and may be covered with yellow pus on the surface, with a foul smell of pus; with a long illness, the edges of the ulcers become thicker and higher, the skin around them is dark, and they are diffusely swollen or accompanied by eczema, and are prone to recurrence after healing; it is more common in patients with varicose veins in the lower limbs.

[0060] (3) Postoperative wound failure: Patients whose wounds fail to heal 10 days after surgery due to foreign matter, dead space left during suturing, poor closure, fat liquefaction, etc.; there is yellow, purulent and bloody secretion at the incision site, and there is necrotic tissue, but there is no tenderness, redness or swelling.

[0061] 3. Inclusion criteria:

[0062] (1) Bed sores: The diagnostic and staging criteria for bedsores refer to the National Bed Ulcer Assessment Program (NPUAP) of the United States and select patients in stages III to IV; blood pressure and blood sugar are stable, and antibiotics are not used for infection control.

[0063] (2) Venous ulcer: confirmed as VLU, meeting the diagnostic criteria of VLU in Western medicine "Surgery" and Traditional Chinese Medicine "Surgery"; unilateral limb disease; ulcer area 2-9 cm 2 .

[0064] (3) Postoperative wound non-healing: history of surgical operation; patients with postoperative wound non-healing, skin ulcer or sinus tract, with a wound area of ​​1-10 cm 2 The sinus tract is about 0.5-5 cm deep (the result obtained by probe exploration).

[0065] 4. Exclusion criteria:

[0066] (1) Bed sores: patients with infection who are taking antibiotics; patients with abnormal coagulation function; patients who are allergic to this patented Chinese medicine; patients with skin tumors; patients who are taking hormones for a long time; patients with poor compliance and inability to fully cooperate.

[0067] (2) Venous ulcers: patients with a history of lower limb surgery / trauma; patients with severe heart, liver, and kidney dysfunction, coagulation dysfunction; patients with diabetes; patients with autoimmune diseases; patients with malignant tumors; patients with allergic constitutions; patients with mental disorders; patients who do not cooperate with the researchers; and patients with incomplete clinical data.

[0068] (3) Non-healing of postoperative wounds: patients who received antibiotics for wound infection after surgery; patients whose postoperative wound sinus tracts were connected to the abdominal cavity or thoracic cavity.

[0069] 5. Treatment method: According to the patient's sore surface and sore surrounding conditions, choose to change the dressing once a day or every other day. First, use chlorhexidine for routine disinfection. Then, according to the size of the wound, apply a layer of the same size of the Chinese medicine oil gauze of the present invention. Then cover it with three pieces of gauze (9cm×7cm), and finally fix it with non-irritating adhesive tape.

[0070] 6. Results:

[0071] The treatment results are shown in Table 1. In Table 1, the standard for cure is complete healing of the wound surface; the standard for marked effect is a significant reduction of the wound area by ≥75%; the standard for effectiveness is a reduction of the wound area by ≥25% and <75%; the standard for ineffectiveness is: the wound area is reduced by <25% or even expanded.

[0072] Table 1

[0073]

[0074] Typical cases cured by the Chinese medicinal oil gauze prepared by the present invention are as follows:

[0075] Typical Case 1: Patient Mao, an 80-year-old male, suffered skin ulceration after scratching his head and face, with the right eye and right forehead being the most affected. His right eye and eyebrow were red, swollen, ulcerated, and eroded, with complete eyebrow loss. Granulation tissue was stale, with abundant purulent secretions and abundant pus crusts. He had irregular skin ulcers measuring approximately 5.0 x 2.5 cm, 2.5 x 1.0 cm, and 1.5 x 1.5 cm on his right forehead and above the hairline, with acceptable granulation tissue. His right nose wing had an area measuring approximately 1.5 x 1.5 cm, with fresh granulation tissue and tenderness (+). He used this analgesic and myogenic oil gauze dressing on August 23, 24, 25, 26, 28, and 30, 2023. Pain was significantly relieved after four consecutive dressing changes. He then changed the dressing every other day and recovered within a week.

[0076] Figure 1 The following are the changes in the wound of a typical case before and after medication, where A to F represent the changes in the wound respectively.

[0077] Typical case 2: Patient Qiao, male, 81 years old, long-term bedridden, had two pressure sores on the left buttocks, measuring 5*3cm and 7*4cm respectively. The surrounding skin was dark red, with 4*2.5cm of black necrotic tissue. Granulation tissue was acceptable, with a small amount of exudate and tenderness (+). He was given analgesic and myogenic oil gauze for external application, with dressing changes every other day. From December 18, 2023 to February 7, 2024, a total of 24 dressing changes were performed, and the sores were healed. The patient was advised to turn over frequently.

[0078] Figure 2 This is a diagram of the wound changes before and after medication in typical case 2, where A to I represent the wound changes respectively.

[0079] Typical case three: Patient Bai Moumou, male, 46 years old, a chef in a hotel, suffered from repeated lower limb ulcers for nearly 20 years due to long-term standing work. He was diagnosed with venous ulcers in an external hospital. This time, the left lower limb ulcer lasted for more than 2 months. He did not see any obvious effect by changing the dressing at home, and the pain gradually increased, so he came to our department for treatment. Physical examination: The patient had an irregular skin ulcer in the foot boot area of ​​the left lower limb, with a range of about 5*2cm, redness and swelling, pigmentation, accompanied by itching, obvious pain, stale granulation tissue, a small amount of purulent secretions, and rough and desquamated skin around the wound. I used the analgesic and myogenic oil gauze of the present invention for external dressing change every other day, and applied pressure bandage with external elastic bandage. The patient recovered after 14 treatments.

[0080] Figure 3 The following are the changes in the wound before and after medication in typical case three, where A to F represent the changes in the wound respectively.

[0081] Typical case 4: Patient Liu, female, 90 years old, was bedridden for a long time after cerebral hemorrhage, resulting in a sacral pressure ulcer. The patient is the grandmother of an employee of our hospital. She took a photo to consult in April 2023. At that time, a sacral pressure ulcer of about 10*10cm was visible on the sacral pressure ulcer, covered with a large amount of black and purulent eschar. She was unable to come to the hospital for treatment, so she asked to take the analgesic and myogenic oil gauze home to change the dressing by herself, and asked the patient to use the cannibalization debridement method and analgesic and myogenic oil gauze dressing to gradually remove the necrotic tissue, and asked her to supplement nutrition, control blood sugar, turn over frequently, and keep the area around the wound clean and dry. During this period, the staff of our hospital intermittently came to our department for dressing guidance. After debridement and nutrition supplementation, granulation tissue grew rapidly until fresh granulation tissue appeared. Then, the analgesic and myogenic oil gauze was used alone for dressing change, every other day. The patient's family persisted for half a year, and it was completely healed until October 2023.

[0082] Figure 4 The following are the changes in the wound before and after medication in typical case 4, where A to F represent the changes in the wound respectively.

[0083] Case 5: Guo, a 38-year-old female, underwent cerebellar herniation surgery at a Beijing hospital in October 2023. Due to poor postoperative wound healing, she was referred to our department on November 20, 2023. Physical examination revealed a 5-cm longitudinal incision at the back of the patient's head, covered with a large amount of slough tissue and pus scab. After thorough debridement, four sinus tracts were discovered. Granulation tissue was not fresh, grayish-white, with a small amount of purulent discharge and significant tenderness. Three sutures had been removed intermittently. Gauze dressings with analgesic and myogenic oil were applied every other day, and the wound healed after 12 days.

[0084] Figure 5 The following are the changes in the wound before and after medication in typical case 5, where A to F represent the changes in the wound respectively.

[0085] Typical Case 6: Patient Sun, a 35-year-old female, underwent right breast cancer surgery and was pathologically diagnosed with mucinous breast carcinoma. She received chemotherapy after surgery. After the fourth round of chemotherapy, she developed an ulcer on her right foot, which continued to enlarge and assume irregular shapes, measuring 5 x 5 cm, 7 x 2 cm, and 1 x 1 cm. Self-treatment with iodine-containing disinfectant failed to improve. She subsequently sought medical attention and received topical Bactroban, but continued to shrink. Due to the persistent wound healing, she was unable to proceed with the next round of chemotherapy. She became anxious and sought treatment from our department. Physical examination revealed irregular, patchy skin ulcers on the medial side of her right foot. Granulation tissue was still fresh, with a thin, pale yellow discharge and significant pain. The ulcer was dark in color, with pale pink epithelial tissue at the edge, and significant adhesion of the gauze to the skin. She was treated with double-layered gauze strips of pain-relieving and myogenic oil every other day, and recovered after seven dressing changes.

[0086] Figure 6 The following are the changes in the wound before and after medication in typical case 6, where A to E represent the changes in the wound respectively.

[0087] Typical case seven: Qin Moumou, female, 59 years old, an inpatient in the Department of Urology, underwent left adrenalectomy in the Department of Urology of our hospital in May 2023. The postoperative wound healing was poor and accompanied by fat liquefaction, so we asked for consultation. The patient had diabetes in the past. Physical examination: obese body, a longitudinal incision of about 10 cm can be seen in the left lower abdomen, 2.5 cm of the upper edge of the incision has not healed, deep into the fascia layer, about 3 cm deep, with a lot of secretions, granulation tissue is still fresh, and obvious pain. The analgesic and myogenic oil gauze dressing of the present invention was given every other day. After half a month, the patient was significantly improved and discharged. After discharge, the dressing of the present invention was continued until recovery.

[0088] Figure 7 The following are the changes in the wound of typical case 7 before and after medication, among which A to F are the changes in the wound respectively.

[0089] Typical case eight: Patient Guo Moumou, female, 71 years old, had nasal redness, swelling and pain without obvious cause on September 30, 2023, and then ulcerated and suppurated on her own to seek medical treatment. Physical examination: The nose was red and swollen, the skin temperature was high, and a sinus tract was visible near the left nostril. The wound range was about 1 cm in diameter and about 3 cm deep. A large amount of purulent secretions were discharged, and the texture was thick. The granulation tissue at the edge of the sore was fresh and tender. Cefdinir capsules were routinely given for anti-inflammatory treatment, and the analgesic and myogenic oil gauze of the present invention was given for daily dressing change. The redness, swelling and secretions of the nose gradually subsided, the pain was significantly relieved, and the patient recovered after 22 days of treatment.

[0090] Figure 8 The following are the changes in the wound before and after medication in typical case 8, where A to F represent the changes in the wound respectively.

[0091] Typical case nine: Du Moumou, male, 70 years old, was admitted to our department in August 2023. Patient's left lower limb skin ulcers were repeated for more than 20 years. It was diagnosed as venous stasis ulcer of lower limbs in local hospital. There was no obvious improvement in hospitalization for half a month. It was suggested to transfer to a higher-level hospital for diagnosis and treatment, so the patient went to our department for outpatient treatment on August 9. Physical examination: left lower limb was dark brown pigmentation, and the peripheral skin was rough, desquamated, thickened, or even lichenified, with slight edema, black eschar, and five irregular skin ulcers were visible, namely 2*1cm, 5*2cm, 2*2cm, 2*2cm, 1*0.5cm, and the granulation tissue was not fresh, easily bleeding, tenderness (+). With the analgesic and myogenic oil gauze of the present invention, the patient's ulcer mouth was obviously reduced after half a month. After being discharged from hospital, the patient took this medicine and changed the dressing at home voluntarily. The outpatient clinic visit was once a week and recovered from the disease on September 13.

[0092] Figure 9 The following are the changes in the wound before and after medication in typical case 9, where A to F represent the changes in the wound respectively.

[0093] Figure 10 The following is a diagram showing the changes in the wound before and after medication in typical case nine, where A to D represent the changes in the wound respectively. Figure 10 A~D are Figure 9 Changes in the wound after F.

[0094] Typical case ten: patient Chen, male, 54 years old, in early December 2023, found a furuncle in the middle of the two shoulder blades of the back, with occasional itching and tingling. The patient did not pay attention to the untreated area, and the redness and swelling range gradually increased, and the pain became more and more serious. Therefore, he went to the general surgery department of a certain hospital for treatment. After hospitalization, he was given abscess incision and drainage under local anesthesia after completing relevant examinations. At the same time, intravenous drip of cefoperazone sulbactam sodium was used for anti-infection treatment for 5 days. The patient was discharged from the hospital and changed the dressing at home by himself. The patient had a history of diabetes in the past and was worried that the wound would not heal. Therefore, he came to our hospital for treatment 10 days after the operation. Physical examination: the incision in the middle of the two shoulder blades of the back was about 6cm long and about 1cm deep. The granulation tissue was okay, scattered in a little white slough, and the amount of purulent secretions was large, tenderness (+). The analgesic and myogenic oil gauze of the present invention was used for daily dressing treatment. The wound gradually shrank, and purulent secretions and pain were gradually alleviated. He recovered after treatment for 32 days.

[0095] Figure 11 The following are the changes in the wound of a typical case before and after medication, where A to D represent the changes in the wound respectively.

[0096] Figure 12 The following are the changes in the wound of a typical case before and after medication, where A to D represent the changes in the wound respectively. Figure 12 A~D are Figure 11 Changes in the wound after F.

[0097] Typical Case 11: Patient Wu, a 76-year-old female, suffered a burn on the dorsum of her left foot during moxibustion treatment one month prior. Initially, blisters developed, which ruptured to form an ulcer approximately the size of a one-yuan coin. She disinfected the ulcer with iodine at home, but it did not improve. The area surrounding the ulcer became red, swollen, and painful, with increasing amounts of slough and purulent discharge. She presented to our outpatient clinic. Physical examination revealed a 3x2 cm ulcer on the dorsum of her left foot, with stale granulation tissue, redness, swelling, and tenderness (+). Analgesic and myogenic gauze dressings were administered, with dressings changed every other day for 11 times before recovery.

[0098] Figure 13 The following is a diagram showing the changes in the wound before and after medication in a typical case 11, where A to F represent the changes in the wound respectively.

[0099] The embodiments described above are merely descriptions of preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Without departing from the spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by persons skilled in the art should fall within the scope of protection defined by the claims of the present invention.

Claims

1. A Chinese medicinal oil for treating chronic skin ulcers, characterized in that: The invention is prepared from the following raw materials in parts by weight: 60-65 parts of frankincense, 60-65 parts of myrrh, 55-65 parts of red peony root, 30-40 parts of lithospermum erythrorhizon, 15-25 parts of angelica dahurica, 10-15 parts of rhubarb, 10-15 parts of sanguisorba officinalis, 12-15 parts of dragon's blood, 10-15 parts of calcined pearl powder, 10-15 parts of catechu, 36-42 parts of liquorice, 90-120 parts of white beeswax, 15-30 parts of honeysuckle and 500-550 parts of sesame oil.

2. A method for preparing the Chinese medicinal oil for treating chronic skin ulcers according to claim 1, characterized in that: The following steps are involved: Add frankincense, myrrh, red peony root, rhubarb, lithospermum officinale, angelica dahurica, raw sanguisorba officinalis, licorice and catechu to the sesame oil and soak, then heat until the angelica dahurica and licorice turn black on the outside and yellow on the inside, stop heating, immediately add honeysuckle, and filter after 30s-60s to remove all the drugs; melt white beeswax and add it to the above medicinal oil, heat until fully blended, cool, and when the temperature drops to 80-90℃, add dragon's blood powder and calcined pearl powder, stir evenly, and filter to obtain the final Chinese medicinal oil for treating chronic skin ulcers.

3. The method for preparing a Chinese medicinal oil for treating chronic skin ulcers according to claim 2, wherein: The soaking temperature is 20-25° C. and the soaking time is 3-5 days.

4. The method for preparing a Chinese medicinal oil for treating chronic skin ulcers according to claim 2, wherein: Heat angelica dahurica and licorice until they turn black on the outside and yellow on the inside at a temperature of 180-200°C.

5. A Chinese medicine oil gauze for treating chronic skin ulcers, characterized in that: The active ingredient is the traditional Chinese medicine oil for treating chronic skin ulcers as claimed in claim 1.

6. The method for preparing the Chinese medicinal oil gauze for treating chronic skin ulcers according to claim 5, characterized in that: The following steps are involved: The Chinese medicinal oil for treating chronic skin ulcers is soaked in sterile gauze and sterilized to obtain the Chinese medicinal oil gauze for treating chronic skin ulcers.

7. Use of the traditional Chinese medicine oil for treating chronic skin ulcers according to claim 1 in preparing a preparation for treating chronic skin ulcers.

8. Use of the Chinese medicinal oil gauze for treating chronic skin ulcers according to claim 5 in preparing a preparation for treating chronic skin ulcers.

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