Bruise composition and method of making same, bruise oil

Abstract

The application discloses a composition for treating traumatic injury and a preparation method thereof, and a traumatic oil yarn. The composition for treating traumatic injury comprises black soybean oil and a compound extract mixed with the black soybean oil, wherein the compound extract comprises oil extracts of the following traditional Chinese medicinal materials: pinellia ternate, prepared wujiabaicang, prepared asters, prepared aconite, ginseng, saposhnicovia divaricata, borneol, safflower, dipsacus asper, paris polyphylla, radix paeoniae, salix caprea leaf and radix scrophulariae. The composition for treating traumatic injury is prepared by compounding the oil extracts of the various traditional Chinese medicinal materials with the black soybean oil, so that the black soybean oil and the extracts of the various traditional Chinese medicinal materials play a mutual synergistic effect, the composition for treating traumatic injury is effectively enhanced in the effects of promoting blood circulation to remove blood stasis, relieving swelling and relieving pain on the tibia sprain, and the composition for treating traumatic injury also has the effect of promoting the healing of broken skin.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicinal materials, and particularly relates to a composition for treating traumatic injury and a preparation method thereof and a composition for treating traumatic injury. BACKGROUND

[0002] Traumatic injury is a common disease, which is mainly caused by falling, hitting, knocking and bumping. Traumatic injury includes sprain, contusion and abrasion. For patients with traumatic injury, early blood circulation and swelling pain relief are needed to relieve pain, reduce ecchymosis and reduce the degree of tissue swelling.

[0003] The existing blood circulation and swelling pain relief drugs in the clinic have poor swelling and blood stasis relieving effect, and most of the existing blood circulation and swelling pain relief drugs in the clinic are external drugs, which need to contact the skin of the injury site and are prone to cause skin allergy and other problems.

[0004] In addition, traumatic injury such as contusion is often accompanied by skin damage. The skin damage caused by traumatic injury is different from the skin damage caused by sharp objects such as knives. The skin damage caused by traumatic injury has no neat incision, and the wound is wide, accompanied by subcutaneous blood vessel damage, blood seeps into the tissue space to cause congestion, and traumatic injury may also cause one or more layers of the epidermis to be abraded, thereby exposing the dermis or subcutaneous tissue. The existing external drugs are not suitable for promoting the repair of damaged skin caused by traumatic injury, and even have certain irritation to the damaged skin, which aggravates the skin damage accompanied by traumatic injury, and even further causes the skin of the damaged part to be red, swollen and suppurative. SUMMARY

[0005] The purpose of the present application is to provide a composition for treating traumatic injury to solve the technical problems of poor effect, easy skin allergy and unsuitable for promoting the healing of damaged skin of the existing blood circulation and swelling pain relief external drugs.

[0006] In a first aspect, the present application provides a composition for treating traumatic injury. The composition for treating traumatic injury of the present application comprises black soybean oil and a compound extract mixed with the black soybean oil, wherein the compound extract comprises oil extracts of traditional Chinese medicinal materials in the following weight proportions:

[0007] Radix et Rhizoma Aconiti Lateralis Preparata 80-120 parts, Radix et Rhizoma Aconiti Carmichaeli Preparata 80-120 parts, Radix et Rhizoma Aconiti Kweichowense Preparata 80-120 parts, Radix et Rhizoma Ginseng 80-120 parts, Radix Saposhnikoviae 80-120 parts, Borneolum Syntheticum 40-60 parts, Flos Carthami 40-60 parts, Radix et Rhizoma Dipsaci 80-120 parts, Rhizoma Paridis 80-120 parts, Radix Paeoniae Alba 40-60 parts, Folium Salicis 80-120 parts, Radix Scophulariae 40-60 parts.

[0008] The traumatic injury composition of the present application embodiment is compounded with multiple Chinese medicinal materials and black bean oil, so that the black bean oil and the oil extracts of each Chinese medicinal material have a synergistic effect, effectively enhancing the blood circulation, blood stasis, swelling and analgesic efficacy of the traumatic injury composition for traumatic injuries and tibial sprains, and also enabling the traumatic injury composition to promote the healing of damaged skin.

[0009] In a second aspect, the present invention provides a method for preparing a traumatic injury composition. The method for preparing a traumatic injury composition according to the present invention comprises the following steps:

[0010] Provide prescription quantities of Chinese herbal medicines;

[0011] The Chinese medicinal materials are subjected to oil-roasting treatment using black bean oil, and then soaked to obtain a mixture containing medicinal residues;

[0012] The mixture is subjected to solid-liquid separation, and the medicinal residue is removed to obtain a traumatic injury composition.

[0013] The preparation method of the present application embodiment uses black soybean oil to oil-roast and soak Chinese medicinal materials, allowing the black soybean oil to interact with the Chinese medicinal materials, effectively extracting the active ingredients from the Chinese medicinal materials, and compounding the black soybean oil with the Chinese medicinal materials to enhance the blood circulation and blood stasis, swelling and analgesic efficacy of the traumatic injury composition for traumatic injuries and tibial sprains, and also enables the traumatic injury composition to promote the healing of damaged skin. In addition, the preparation method of the present application embodiment has a few process steps and controllable process parameters, making it suitable for large-scale industrial production and application of the traumatic injury composition.

[0014] In a third aspect, the present application provides an embodiment of a traumatic injury oil gauze. The traumatic injury oil gauze of the embodiment of the present application comprises a traumatic injury composition and a fiber carrier, wherein the traumatic injury composition is loaded on the fiber carrier, and the traumatic injury composition is the traumatic injury composition of the first aspect or the traumatic injury composition prepared by the preparation method of the second aspect.

[0015] Since the traumatic injury oil gauze in the embodiment of the present application includes the traumatic injury composition described above, it has good medicinal effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain for traumatic injuries and tibial trauma, and can also effectively promote the healing of damaged skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments or descriptions of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained like these drawings without any creative work.

[0017] Figure 1 This is a process flow chart of the preparation method of the traumatic injury composition according to the embodiment of the present application. DETAILED DESCRIPTION

[0018] In order to make the technical problems, technical solutions and beneficial effects to be solved in the present application clearer, the present application will be further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only intended to explain the present application and not to limit the present application.

[0019] In the present application, the term "and / or" describes the association relationship of the associated objects, which means that there can be three kinds of relationships, for example, A and / or B can mean that A exists alone, A and B exist together, and B exists alone. Wherein A and B can be singular or plural. The character " / " generally represents that the associated objects before and after it are in an "or" relationship.

[0020] In the present application, "at least one" means one or more, and "multiple" means two or more. "At least one of the following" or similar expressions means any combination of these items, including any combination of single item or multiple items. For example, "at least one of a, b, or c", or "at least one of a, b, and c", can mean a, b, c, a-b (i.e. a and b), a-c, b-c, or a-b-c, wherein a, b, and c can be single or multiple.

[0021] It should be understood that in various embodiments of the present application, the size of the sequence number of the above processes does not mean the order of execution, and part or all of the steps can be executed in parallel or in sequence, and the execution order of each process should be determined according to its function and inherent logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0022] The terms used in the embodiments of the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application. The singular forms "a" and "the" used in the embodiments of the present application and the appended claims are also intended to include the plural forms, unless the context clearly indicates otherwise.

[0023] The weight of the related components mentioned in the specification of the embodiments of the present application can not only refer to the specific content of each component, but also represent the weight ratio relationship between each component, therefore, as long as the content of the related components in the specification of the embodiments of the present application is enlarged or reduced in proportion, it is within the scope disclosed in the specification of the embodiments of the present application. Specifically, the mass in the specification of the embodiments of the present application can be μg, mg, g, kg and other mass units commonly known in the chemical field.

[0024] In a first aspect, the embodiments of the present application provide a composition for treating traumatic injury. The composition for treating traumatic injury comprises black bean oil and a compound extract mixed with the black bean oil, wherein the compound extract comprises oil extract of the following weight fractions of Chinese medicinal materials:

[0025] Ginger pinellia 80-120 parts, prepared grass wu 80-120 parts, prepared southern star 80-120 parts, prepared Sichuan wu 80-120 parts, ginseng 80-120 parts, silvertop 80-120 parts, borneol 40-60 parts, safflower 40-60 parts, continue to break 80-120 parts, cymbidium 80-120 parts, yellow root 40-60 parts, willow bean leaf 80-120 parts, yellow 40-60 parts.

[0026] In the application embodiment, the traditional Chinese medicine materials as the source of the compound extract constitute a traditional Chinese medicine compound prescription. The mixing with black bean oil means that the compound extract is arranged in the black bean oil in the form of dissolution and / or dispersion.

[0027] The yellow root in the traditional Chinese medicine compound prescription is also known as dog bone wood, which is the dried root of Rubiaceae; the willow bean leaf is also known as the leaf of the bean plant, which is the dried leaf of the bean plant; and the black bean oil is the oil obtained from black beans.

[0028] The application embodiment of the composition for treating traumatic injury is prepared by compounding the black bean oil with the traditional Chinese medicine materials such as the yellow root, the willow bean leaf, the yellow 40-60 parts, and the ginger pinellia, and controlling the proportion of each traditional Chinese medicine material, so that the black bean oil and the oil extract of each traditional Chinese medicine material play a mutual synergistic effect, effectively enhancing the efficacy of promoting blood circulation to remove blood stasis, detumescence and analgesia of the composition for treating traumatic injury. In addition, the composition for treating traumatic injury also has the effect of promoting the repair of damaged skin accompanying traumatic injury, and can greatly reduce the occurrence of skin allergic reactions.

[0029] In some embodiments, the weight fraction of ginger pinellia can also be 90-110 parts. In the exemplary examples, the weight fraction of ginger pinellia can be 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts, 105 parts, 108 parts, 110 parts, 112 parts, 115 parts, 118 parts, 120 parts, and the like typical but non-limiting weight fractions or any two weight fraction ranges. The ginger pinellia in this content range can improve the prescription compounding effect between ginger pinellia and other components on the basis of exerting its single drug function of eliminating mass and resolving nodes, further improving the efficacy of the composition for treating traumatic injury.

[0030] In some embodiments, the weight fraction of prepared grass wu can also be 90-110 parts. In the exemplary examples, the weight fraction of prepared grass wu can be 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts, 105 parts, 108 parts, 110 parts, 112 parts, 115 parts, 118 parts, 120 parts, and the like typical but non-limiting weight fractions or any two weight fraction ranges. The prepared grass wu in this content range can improve the prescription compounding effect between prepared grass wu and other components on the basis of exerting its single drug function of dredging meridians, further improving the efficacy of the composition for treating traumatic injury.

[0031] In some embodiments, the weight fraction of Rhizoma Arisaematis can also be 90-110 parts. In exemplary examples, the weight fraction of Rhizoma Arisaematis can be 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts, 105 parts, 108 parts, 110 parts, 112 parts, 115 parts, 118 parts, 120 parts, and the like typical but non-limiting weight fractions or fractions between any two weight fraction ranges. Rhizoma Arisaematis in this content range can improve the prescription compounding effect between Rhizoma Arisaematis and other components on the basis of exerting its single drug function of resolving masses and dissipating swelling, further improving the efficacy of the bruise composition.

[0032] In some embodiments, the weight fraction of Radix et Rhizoma Aconiti can also be 90-110 parts. In exemplary examples, the weight fraction of Radix et Rhizoma Aconiti can be 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts, 105 parts, 108 parts, 110 parts, 112 parts, 115 parts, 118 parts, 120 parts, and the like typical but non-limiting weight fractions or fractions between any two weight fraction ranges. Radix et Rhizoma Aconiti in this content range can improve the prescription compounding effect between Radix et Rhizoma Aconiti and other components on the basis of exerting its single drug function of warming meridians and relieving pain, further improving the efficacy of the bruise composition.

[0033] In some embodiments, the weight fraction of Radix et Rhizoma Aconiti can also be 90-110 parts. In exemplary examples, the weight fraction of Radix et Rhizoma Aconiti can be 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts, 105 parts, 108 parts, 110 parts, 112 parts, 115 parts, 118 parts, 120 parts, and the like typical but non-limiting weight fractions or fractions between any two weight fraction ranges. Radix et Rhizoma Aconiti in this content range can improve the prescription compounding effect between Radix et Rhizoma Aconiti and other components on the basis of exerting its single drug function of warming meridians and relieving pain, further improving the efficacy of the bruise composition.

[0034] In some embodiments, the weight fraction of Radix et Rhizoma Aconiti can also be 90-110 parts. In exemplary examples, the weight fraction of Radix et Rhizoma Aconiti can be 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts, 98 parts, 100 parts, 102 parts, 105 parts, 108 parts, 110 parts, 112 parts, 115 parts, 118 parts, 120 parts, and the like typical but non-limiting weight fractions or fractions between any two weight fraction ranges. Radix et Rhizoma Aconiti in this content range can improve the prescription compounding effect between Radix et Rhizoma Aconiti and other components on the basis of exerting its single drug function of warming meridians and relieving pain, further improving the efficacy of the bruise composition.

[0035] The main component of borneol is borneol. In some embodiments, the weight percentage of borneol can also be 45-55 parts. In exemplary embodiments, the weight percentage of borneol can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, and the like, typical but non-limiting weight percentages or parts between any two weight percentage ranges. The borneol in this content range can improve the prescription compounding effect between borneol and other components on the basis of its single drug heat-clearing and detoxifying, swelling and pain-relieving functions, further improving the efficacy of the composition for treating sprains and strains.

[0036] In some embodiments, the weight percentage of safflower can also be 45-55 parts. In exemplary embodiments, the weight percentage of safflower can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, and the like, typical but non-limiting weight percentages or parts between any two weight percentage ranges. Safflower is a blood-activating and stasis-removing drug that can improve the prescription compounding effect between safflower and other components on the basis of its single drug blood-activating and stasis-removing, blood-activating and pain-relieving functions, further improving the efficacy of the composition for treating sprains and strains.

[0037] In some embodiments, the weight percentage of safflower can also be 45-55 parts. In exemplary embodiments, the weight percentage of safflower can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, and the like, typical but non-limiting weight percentages or parts between any two weight percentage ranges. Safflower is a blood-activating and stasis-removing drug that can improve the prescription compounding effect between safflower and other components on the basis of its single drug blood-activating and stasis-removing, blood-activating and pain-relieving functions, further improving the efficacy of the composition for treating sprains and strains.

[0038] In some embodiments, the weight percentage of safflower can also be 45-55 parts. In exemplary embodiments, the weight percentage of safflower can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, and the like, typical but non-limiting weight percentages or parts between any two weight percentage ranges. Safflower is a blood-activating and stasis-removing drug that can improve the prescription compounding effect between safflower and other components on the basis of its single drug blood-activating and stasis-removing, blood-activating and pain-relieving functions, further improving the efficacy of the composition for treating sprains and strains.

[0039] In some embodiments, the weight fraction of the root of the Chinese weeping forsythia can also be 45-55 parts. In exemplary embodiments, the weight fraction of the root of the Chinese weeping forsythia can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, and the like typical but non-limiting weight fractions or fractions between any two weight fraction ranges. The root of the Chinese weeping forsythia in this content range, on the basis of exerting its single-drug function of removing blood stasis and generating new blood, can improve the compounding effect between the root of the Chinese weeping forsythia and other components of the prescription, and further improve the efficacy of the composition for treating traumatic injury.

[0040] In some embodiments, the weight fraction of the root of the Chinese weeping forsythia can also be 45-55 parts. In exemplary embodiments, the weight fraction of the root of the Chinese weeping forsythia can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, and the like typical but non-limiting weight fractions or fractions between any two weight fraction ranges. The root of the Chinese weeping forsythia in this content range, on the basis of exerting its single-drug function of removing blood stasis and generating new blood, can improve the compounding effect between the root of the Chinese weeping forsythia and other components of the prescription, and further improve the efficacy of the composition for treating traumatic injury.

[0041] In some embodiments, the weight fraction of the root of the Chinese weeping forsythia can also be 45-55 parts. In exemplary embodiments, the weight fraction of the root of the Chinese weeping forsythia can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts, and the like typical but non-limiting weight fractions or fractions between any two weight fraction ranges. The root of the Chinese weeping forsythia in this content range, on the basis of exerting its single-drug function of removing blood stasis and generating new blood, can improve the compounding effect between the root of the Chinese weeping forsythia and other components of the prescription, and further improve the efficacy of the composition for treating traumatic injury.

[0042] It should be noted that each Chinese medicinal material in the Chinese herbal compound prescription in the embodiments of the present application is a Chinese medicinal material meeting the relevant provisions of the Chinese Pharmacopoeia. When the Chinese Pharmacopoeia does not collect the Chinese medicinal material, the Chinese medicinal material can be inspected and tested according to the local Chinese medicinal material standard.

[0043] In some embodiments, the concentration of the compound extract in the bruise composition can be controlled by the oil extract contained in the black bean oil. In further embodiments, the total weight of the oil extract extracted from the Chinese medicinal materials contained in 1 kg of black bean oil is 400-500 g, which can be optionally 420-480 g. In exemplary embodiments, the total weight of the Chinese medicinal materials used to extract the oil extract contained in 1 kg of black bean oil can be 400 g, 410 g, 420 g, 430 g, 440 g, 450 g, 460 g, 470 g, 480 g, 490 g, 500 g, or any weight within the range of any two values. Controlling the total weight of the Chinese medicinal materials used to extract the oil extract contained in 1 kg of black bean oil within the range, and further controlling the content of the compound extract in the black bean oil, can promote the synergistic effect between the black bean oil and the compound extract, and further improve the blood-activating and stasis-removing, swelling-relieving and pain-relieving effects of the bruise composition, and further improve the healing effect of the bruise composition on broken skin.

[0044] In some embodiments, the oil extract of the Chinese medicinal materials can be a black bean oil extract, i.e., an oil extract obtained by extraction with black bean oil as the solvent. The black bean oil extract of the Chinese medicinal materials is beneficial to further improve the blood-activating and stasis-removing, swelling-relieving and pain-relieving, and broken skin healing effects of the bruise composition.

[0045] In a second aspect, the embodiments of the present application provide a preparation method of the bruise composition described above. The preparation method of the embodiments of the present application comprises the following steps:

[0046] Step S10, providing a prescribed amount of Chinese medicinal materials;

[0047] Step S20, performing oil roasting treatment on the Chinese medicinal materials with black bean oil, and then performing soaking treatment to obtain a mixture containing residues;

[0048] Step S30, performing solid-liquid separation on the mixture to remove the residues and obtain the bruise composition.

[0049] The preparation method of the embodiments of the present application extracts the active ingredients in the Chinese medicinal materials by oil roasting treatment and soaking treatment, and effectively improves the efficacy of the bruise composition by compounding the black bean oil with the Chinese medicinal materials, so that the prepared bruise composition has good therapeutic effect on bruise and muscle and bone injury, can quickly and efficiently achieve the effects of blood-activating and stasis-removing, swelling-relieving and pain-relieving at the site of muscle and bone injury, and in particular, when the bruise and muscle and bone injury is accompanied by broken skin, the bruise composition not only has the effects of blood-activating and stasis-removing, swelling-relieving and pain-relieving, but also can promote the repair of broken skin. In addition, the preparation method of the embodiments of the present application has few process steps and controllable process parameters, and is suitable for large-scale industrial production and application of the bruise composition.

[0050] Step S10:

[0051] The Chinese medicinal material is provided in a prescribed amount according to the prescription in the above. The Chinese medicinal material is the pinellia ternata, prepared aconite, prepared rhizoma anemarrhena asphodeloides, etc. in the above Chinese medicinal compound prescription, which will not be repeated here.

[0052] In some embodiments, the Chinese medicinal material can also be pretreated. In embodiments, water can be used to wet and soften the inside of the Chinese medicinal material. In further embodiments, water can be used to soak and steam the Chinese medicinal material. In specific examples, the Chinese medicinal material can be packaged one dose per bag, and after packaging, each bag of Chinese medicinal material is soaked in water and then steamed in a water bath. In specific examples, the time for the water bath can be 0.5 h, 1 h, 2 h, 3 h, etc. typical but non-limiting time or any time between any two time ranges. The water bath is to steam the Chinese medicinal material above the boiling water. After the water bath, the Chinese medicinal material is dried, and the wet Chinese medicinal material is obtained. The inside of the Chinese medicinal material is soaked by the wetting treatment, and after the water bath, the structure of the inside of the Chinese medicinal material is softened, so that the oil can better penetrate into the inside of the Chinese medicinal material in the subsequent oil frying process, thereby improving the effect of oil frying and enhancing the efficacy of the composition for treating sprains and strains.

[0053] Step S20:

[0054] In step S20, the Chinese medicinal material is treated with black bean oil, and after the oil frying treatment, the Chinese medicinal material is soaked in the black bean oil treated by oil frying to promote the interaction between the black bean oil and the Chinese medicinal material and the extraction of effective components in the Chinese medicinal material, and a mixture containing residues is obtained.

[0055] In some embodiments, the black bean oil is extracted from black beans, and the extraction method of the black bean oil can include mechanical oil pressing, solvent extraction, liquid ion exchange, supercritical fluid method, etc. without limitation. The black bean oil can also be commercially available.

[0056] In some embodiments, the black bean oil and the Chinese medicinal materials are mixed in a mass ratio of 11:(23-25) during the oil roasting process. In some exemplary embodiments, the mass ratio of the total mass of the Chinese medicinal materials to the mass of the black bean oil can be 11:23, 11:23.5, 11:24, 11:24.5, 11:25, or any ratio within the range of any two of the above ratios. Controlling the mass ratio of the total mass of the Chinese medicinal materials to the mass of the black bean oil within the range can enable the Chinese medicinal materials to be immersed in the black bean oil during the subsequent oil roasting and soaking processes, thereby promoting the interaction between the black bean oil and the Chinese medicinal materials and improving the extraction efficiency of the effective components in the Chinese medicinal materials. In addition, controlling the mass ratio of the black bean oil and the Chinese medicinal materials within the range can further improve the content of the compound extract in the black bean oil, promote the compounding of the black bean oil and the compound extract, and further improve the efficacy of the composition for treating traumatic injuries.

[0057] In some embodiments, the oil roasting process can be performed at a temperature of 200-230°C, or 220-230°C. In some exemplary embodiments, the oil roasting process can be performed at a temperature of 200°C, 205°C, 210°C, 215°C, 220°C, 225°C, 230°C, or any temperature within the range of any two of the above temperatures. Controlling the temperature of the oil roasting process within the range can further improve the interaction between the black bean oil and the Chinese medicinal materials, thereby further improving the efficacy of the composition for treating traumatic injuries. After the oil roasting process, the surface of the wooden Chinese medicinal materials is carbonized, and the inside of the Chinese medicinal materials is brown.

[0058] In some embodiments, the container used for the oil roasting process can be a ceramic container. Performing the oil roasting process in a ceramic container can reduce the introduction of metal ions during the oil roasting process.

[0059] In some embodiments, a condensing device can be used to condense the components volatilized during the oil roasting process, thereby reducing the volatilization of the black bean oil and the effective components during the oil roasting process.

[0060] In some embodiments, the soaking process can be performed at a temperature of 10-30°C, or 10-20°C. In some exemplary embodiments, the soaking process can be performed under cool conditions. In other exemplary embodiments, the soaking process can be performed at a temperature of 10°C, 11°C, 12°C, 13°C, 14°C, 15°C, 16°C, 17°C, 18°C, 19°C, 20°C, 21°C, 22°C, 23°C, 24°C, 25°C, 26°C, 27°C, 28°C, 29°C, 30°C, or any temperature within the range of any two of the above temperatures.

[0061] In some embodiments, the soaking treatment can be performed for 30-45 days, optionally for 30-40 days. In exemplary embodiments, the soaking treatment can be performed for 30 days, 32 days, 35 days, 38 days, 40 days, 42 days, 45 days, or any other exemplary but non-limiting time or time range.

[0062] The temperature and time of the soaking treatment are controlled within a range to allow the black bean oil to sufficiently infiltrate the inside of the Chinese medicinal material, to promote the interaction between the black bean oil and the Chinese medicinal material, to increase the content of the compound extract in the black bean oil, and to reduce the volatilization of the black bean oil and the compound extract during the soaking treatment, thereby further improving the efficacy of the composition for treating traumatic injuries.

[0063] In some embodiments, stirring can be performed during the soaking treatment to allow the components in the mixture to be sufficiently mixed and homogenized, thereby further improving the extraction rate of the effective components.

[0064] In some embodiments, the soaking treatment can be performed in a ceramic container, such as a ceramic jar.

[0065] Step S30:

[0066] The mixture is subjected to solid-liquid separation by step S30 to remove the dregs of the Chinese medicinal material from the mixture, and the liquid is collected to obtain the composition for treating traumatic injuries. The solid-liquid separation can be performed by filtration, centrifugation, or the like, and the specific method is not limited as long as the dregs of the Chinese medicinal material are removed.

[0067] In a third aspect, the embodiments of the present application provide a composition for treating traumatic injuries in the form of an oil-soaked gauze. The oil-soaked gauze comprises the composition for treating traumatic injuries and a fibrous carrier, and the composition for treating traumatic injuries is loaded on the fibrous carrier.

[0068] The oil-soaked gauze of the present application has good effects on traumatic injuries and injuries of muscles and bones, and can quickly and efficiently achieve the effects of promoting blood circulation to remove blood stasis, reducing swelling, and relieving pain at the site of the injured muscles and bones. In addition, the oil-soaked gauze can also effectively promote the repair of damaged skin accompanying traumatic injuries and injuries of muscles and bones.

[0069] In some embodiments, the fibrous carrier can comprise gauze, and the composition for treating traumatic injuries can infiltrate the gauze in the oil-soaked gauze.

[0070] In some embodiments, the oil-soaked gauze can be prepared by placing the gauze in the composition for treating traumatic injuries so that the gauze is completely soaked by the composition for treating traumatic injuries.

[0071] In some embodiments, the specification of the fibrous carrier of the oil-soaked gauze can be set according to actual needs. In exemplary embodiments, the specification of the fibrous carrier can be 7*10 cm.

[0072] The oil gauze can be externally applied, and in some embodiments, 2-4 pieces of the oil gauze are externally applied each time of use, once every 3 days. In other embodiments, the oil gauze can be externally applied and continue to be fixed with a splint, and the patient is advised to pay attention to lifting the affected limb, and the dressing is changed after 1 week.

[0073] To enable the above-described implementation details and operations of the present application to be clearly understood by those skilled in the art, and to further demonstrate the significant performance of the bruise composition and the preparation method thereof, and the oil gauze, the following examples are used to illustrate the above technical solutions.

[0074] 1. Bruise composition and preparation method thereof

[0075] Example A1

[0076] The present example provides a bruise composition, which comprises black bean oil and a compound extract mixed with the black bean oil, the compound extract being extracted from traditional Chinese medicinal materials shown in Table 1. The raw materials for preparing the bruise composition of the present example are shown in Table 1.

[0077] The preparation method of the bruise composition of the present example is as follows:

[0078] Step S1, provide the traditional Chinese medicinal materials shown in Table 1, without powdering treatment, directly package the traditional Chinese medicinal materials shown in Table 1 according to one dose per bag, after adding an appropriate amount of water to each bag of medicinal materials for wetting and soaking, place it in a water bath for 1 hour, and dry it.

[0079] Step S2, place the dried traditional Chinese medicinal materials of step S1 into a pottery jar, add 230°C boiling black bean oil to the pottery jar according to the weight shown in Table 1, and perform oil roasting treatment on the traditional Chinese medicinal materials. After the oil roasting treatment, the surface of the medicinal materials is carbonized, and the inside of the medicinal materials is brown. After the oil roasting treatment, place the pottery jar containing the mixture of the traditional Chinese medicinal materials and the black bean oil in a cool place, so that the traditional Chinese medicinal materials are soaked in the black bean oil, and stir once a week. Soak for one month.

[0080] Step S3, after the pottery jar in step S2 is placed in a cool place for one month, take out the mixture in the pottery jar, filter it with double-layer gauze, take the filtrate, and obtain the bruise composition of the present example.

[0081] Examples A2 to A5

[0082] Examples A2 to A5 are each a bruise composition, and the bruise composition and the preparation method thereof of Examples A2 to A5 are basically the same as those of Example A1, except that the traditional Chinese medicinal materials in the bruise composition of Examples A2 to A5 are shown in Table 1, and the temperature of the black bean oil added to the pottery jar during the preparation of the bruise composition of Example A5 is 210°C.

[0083] Comparative Example A1

[0084] The present comparative example provides a composition for treating traumatic injury. The composition for treating traumatic injury of the present comparative example and the method for preparing the same are substantially the same as those of Example Al, except that soybean oil is used instead of black bean oil in the present comparative example.

[0085] Comparative Example A2

[0086] The present comparative example provides a composition for treating traumatic injury. The composition for treating traumatic injury of the present comparative example and the method for preparing the same are substantially the same as those of Example Al, except that the Chinese medicinal materials used in the present comparative example do not contain Huanggen.

[0087] Comparative Example A3

[0088] The present comparative example provides a composition for treating traumatic injury. The composition for treating traumatic injury of the present comparative example and the method for preparing the same are substantially the same as those of Example Al, except that the Chinese medicinal materials used in the present comparative example do not contain Liandouye.

[0089] Comparative Example A4

[0090] The present comparative example provides a composition for treating traumatic injury. The composition for treating traumatic injury of the present comparative example and the method for preparing the same are substantially the same as those of Example Al, except that the Chinese medicinal materials used in the present comparative example do not contain Huangqi.

[0091] Comparative Example A5

[0092] The present comparative example provides a composition for treating traumatic injury. The composition for treating traumatic injury of the present comparative example and the method for preparing the same are substantially the same as those of Example Al, except that soybean oil is used instead of black bean oil in the present comparative example, and the Chinese medicinal materials used in the present comparative example do not contain Huanggen, Liandouye, and Huangqi.

[0093] Table 1: Amount of raw materials used in the preparation of the composition for treating traumatic injury (g)

[0094]

[0095]

[0096] 3. Oil for treating traumatic injury

[0097] Example Bl

[0098] The present example provides an oil for treating traumatic injury. The oil for treating traumatic injury of the present example comprises the composition for treating traumatic injury of Example Al and gauze, and the composition for treating traumatic injury is loaded on the gauze. The method for preparing the oil for treating traumatic injury of the present example is as follows:

[0099] Take 150 pieces of 7 x 10 cm gauze and put them into the composition of Example Al to make the gauze fully soaked by the composition, thus obtaining the gauze of the present example.

[0100] Examples B1 to B5 and Comparative Examples B1 to B4

[0101] Examples B1 to B5 and Comparative Examples B1 to B4 respectively provide a gauze for treating traumatic injury. The gauze for treating traumatic injury of Examples B1 to B5 and Comparative Examples B1 to B4 and the method for preparing the same are substantially the same as the gauze for treating traumatic injury of Example Bl, except that the composition for treating traumatic injury contained in the gauze for treating traumatic injury of Example Bl is the composition for treating traumatic injury provided in Example Al, the composition for treating traumatic injury contained in the gauze for treating traumatic injury of Example B2 is the composition for treating traumatic injury provided in Example A2, and so on, and the composition for treating traumatic injury contained in the gauze for treating traumatic injury of Comparative Example B3 is the composition for treating traumatic injury provided in Comparative Example A4.

[0102] 3. Efficacy investigation

[0103] Tension blister is a common complication in limb fracture, especially in closed fracture. The clinical manifestation is very similar to that of Ⅱ degree scald blister, which is very easy to break and its content can be light yellow transparent liquid, bloody liquid, and occasionally purulent turbid liquid. The existence of tension blister affects the healing of the fracture site of the patient and increases the risk of infection. Therefore, in clinical practice, it is very important to quickly and effectively solve the tension blister and eliminate the swelling of the local tissue to make the skin of the patient heal as soon as possible.

[0104] Select 44 cases of closed fracture of limbs, of which 36 cases are divided into 6 groups, namely Group Al to Group A6, 6 cases in each group, and the gauze for treating traumatic injury of Example Bl, Comparative Example Bl to Comparative Example B4 is applied to the cases in different groups according to Table 1, and the other 8 cases are divided into 4 groups, 2 cases in each group, namely Group Bl to Group B4, wherein Group Bl applies the gauze for treating traumatic injury of Example B2, wherein Group B2 applies the gauze for treating traumatic injury of Example B3, wherein Group B3 applies the gauze for treating traumatic injury of Example B4, and wherein Group B4 applies the gauze for treating traumatic injury of Example B5. Among them, the recovery conditions of typical cases in Group Al and Group A6 are as follows:

[0105] Group Al (Example Bl)

[0106] The 6 cases in Group Al apply the gauze for treating traumatic injury of Example Bl, and the observation process of a typical case is as follows:

[0107] Zheng, male, 32 years old, 1 day ago fell and caused left wrist swelling, deformity, to our hospital emergency treatment, DR examination, show: left distal radius fracture, manual reduction and small splint fixation. 1 day later, the splint fixation appeared blisters, local skin damage, so to our hospital orthopedic clinic, after removing the splint, see: left upper limb local swelling, local tenderness, activity limitation, skin lines disappear, skin taut, blisters at the fracture site, edge redness, blisters see yellow transparent liquid, the largest about 2cm*3cm, multiple blisters have broken, the base of red, with yellow liquid out. Diagnosis: left distal radius fracture after tension blisters. With a sterile needle to pick up the water blister drainage after the black bean oil gauze, continue to splint fixation, patients pay attention to elevate the affected limb, 1 week later dressing change.

[0108] 1 week after recheck: patients left upper limb pain significantly reduced, splint fixation in place. Physical examination: left upper limb local swelling significantly eased, tenderness significantly reduced, activity still limited, skin lines exist, broken water blisters no exudation, edge slightly red and swollen, no broken water blisters absorption, water blisters are all scab formation. Dressing change, continue to use the oil gauze, 1 week later dressing change.

[0109] 2 weeks after recheck: patients left upper limb slightly painful, splint fixation in place. Physical examination: left upper limb no obvious swelling, light tenderness, activity slightly limited, water blisters are all scab, local scab off. Dressing change, continue to use the black bean gauze, 1 week later dressing change.

[0110] 3 weeks after recheck: patients left upper limb no pain, splint fixation in place. Physical examination: left upper limb no swelling, tenderness not obvious, activity slightly limited, water blisters are all scab off. Dressing change, continue to use the black bean gauze, 1 week later dressing change.

[0111] 4 weeks after recheck: patients left upper limb no pain, splint fixation in place. Physical examination: left upper limb no swelling, no obvious tenderness, activity no obvious limited. Remove the splint, patients pay attention to rest, appropriate weight, appropriate function exercise, no intense exercise.

[0112] The case observation process of the remaining 5 patients in group A1 is similar to the case observation process of the typical case Zheng, as shown in Table 2, 1 week after recheck, the pain of the affected area was significantly reduced, physical examination showed that the broken water blisters had no exudation, the edge was slightly red and swollen, the unbroken water blisters were absorbed, and the water blisters were all scabbed. 2 weeks after recheck, the affected area was slightly painful, physical examination showed that the affected area had no obvious swelling, light tenderness, and slight activity limitation, and the water blisters were all scabbed, with local scab off. 3 weeks after recheck, the affected area was painless, physical examination showed that the affected area had no swelling, no obvious tenderness, and slight activity limitation, and the water blisters were all scabbed off. 4 weeks after recheck, the affected area was painless, physical examination showed that the affected area had no swelling, no obvious tenderness, and no obvious activity limitation.

[0113] Group A2 (Comparative Example B1)

[0114] 6 cases in group A2 used the dipu oil gauze outside, in which the typical case observation process was as follows:

[0115] Li, male, 42 years old, 2 days ago when climbing stairs, fell and hit the right wrist, there was right wrist swelling, deformity, to the hospital, DR examination showed: right distal radius fracture, after manual reduction, fixed with small splint. 1 day later, the splint fixed place appeared blisters, local skin damage, so to the orthopedic clinic of our hospital, after removing the splint, see: right upper limb local swelling, local tenderness, limited activity, skin lines disappeared, skin taut, four blisters were seen at the fracture site, with red edge, yellow transparent liquid was seen in the blister, the largest was about 2cm*2cm, two blisters had broken, the base was red, with yellow liquid flowing out. Diagnosis: right distal radius fracture and tension blisters. The blisters were picked and the dipu oil gauze was applied, and the patient was advised to elevate the affected limb, and the dressing was changed after 1 week.

[0116] 1 week later: the patient's right upper limb pain was significantly reduced, and the splint was in place. Physical examination showed that the right upper limb swelling was relieved, the tenderness was significantly reduced, the activity was still limited, the skin lines were present, the blisters were not exuding, the edge was slightly red and swollen, and the unbroken blisters were absorbed, with local scab formation. Dressing change, continue to apply dipu oil gauze, change dressing after 1 week.

[0117] 2 weeks later: the patient's right upper limb was slightly painful, and the splint was in place. Physical examination showed that the right upper limb was slightly swollen, with light tenderness, and the activity was slightly limited. The blisters were scabbed. Dressing change, continue to apply dipu oil gauze, change dressing after 1 week.

[0118] 3 weeks later: the patient's right upper limb was painless, and the splint was in place. Physical examination showed that the right upper limb had no obvious swelling, the tenderness was not obvious, the activity was slightly limited, the blisters were scabbed, and the local scab fell off. Dressing change, continue to apply dipu oil gauze, change dressing after 1 week.

[0119] 4 weeks later: the patient's right upper limb was painless, and the splint was in place. Physical examination showed that the right upper limb had no swelling, no obvious tenderness, and no obvious limitation of activity. The blisters were scabbed and fell off. Remove the splint, advise the patient to rest, appropriate weight bearing, and appropriate functional exercise, avoid strenuous exercise.

[0120] The case observation process of the remaining 5 patients in group A2 is similar to that of the typical case of Li, as shown in Table 2. After 1 week, the patient returned for a follow-up visit and the pain in the affected area was significantly reduced. Physical examination showed that the local swelling was relieved, the tenderness was significantly reduced, the activity was still limited, the skin lines on the affected limb were present, the blister on the broken area had no exudation, the edge was slightly red and swollen, the blister on the unbroken area was absorbed, and local scab formation occurred. After 2 weeks, the patient returned for a follow-up visit and the affected area was slightly painful. Physical examination showed that the affected area was slightly swollen, with light tenderness and slightly limited activity. The blisters were all scabbed. After 3 weeks, the patient returned for a follow-up visit and the affected area was painless. Physical examination showed that the affected area was not significantly swollen, with no obvious tenderness and slightly limited activity. The blisters were all scabbed and the local scab fell off. After 4 weeks, the patient returned for a follow-up visit and the affected area was painless. Physical examination showed that the affected area was not swollen, with no obvious tenderness and no obvious limitation of activity. The blisters were all scabbed and fell off.

[0121] Group A3 (Comparative Example B2)

[0122] The 6 cases in group A3 used Comparative Example B2, and the typical case observation process is as follows:

[0123] Sun, male, 35 years old, 1 day ago, accidentally hit by heavy object, right upper limb swelling, deformity, to our hospital emergency treatment, DR examination, show: right hand distal radius fracture, manual reduction after fixed with small splint. 1 day later, the splint fixed water blister, local skin damage, to our hospital orthopedic clinic, after removing the splint, see: right upper limb local swelling, local tenderness, limited activity, skin lines on the affected limb disappeared, skin tightness bright, fracture site see multiple water blisters, edge red and swollen, water blisters see yellow transparent liquid, the largest about 2cm*2cm, multiple water blisters have broken, base red, with yellow liquid flow out. Diagnosis: right distal radius fracture after tension blister formation. Pick the water blister with added black bean yarn, adjust the splint, ask the patient to pay attention to elevate the affected limb, 1 week later change dressing.

[0124] 1 week later: the patient's right upper limb pain was relieved, and the splint was in place. Physical examination showed that the right upper limb local swelling was relieved, the tenderness was significantly reduced, the activity was still limited, the skin lines on the affected limb were present, the broken water blister had slight exudation, the edge was red and swollen, the unbroken water blister was absorbed, and local scab formation occurred. Change dressing, continue to use added black bean yarn, 1 week later change dressing.

[0125] 2 weeks later: the patient's right upper limb pain was significantly improved, and the splint was in place. Physical examination showed that the right upper limb was slightly swollen, with light tenderness, the skin lines on the affected limb were present, the activity was slightly limited, the edge was slightly red and swollen, and the blisters were all scabbed. Change dressing, continue to use added black bean yarn, 1 week later change dressing.

[0126] Week 3: The patient's right upper limb was painless, and the splint was in place. Physical examination showed that the right upper limb was not obviously swollen, and the tenderness was not obvious. The activity was slightly limited, and the scab at the blister site was shed. The dressing was changed, and the modified black bean yarn was continued to be applied externally, and the dressing was changed after 1 week.

[0127] Week 4: The patient's right upper limb was painless, and the splint was in place. Physical examination showed that the right upper limb was not swollen, and the tenderness was not obvious. The activity was not obviously limited, and the scab at the blister site was shed. The splint was removed, and the patient was advised to rest, bear weight appropriately, and perform functional exercise without intense exercise.

[0128] The case observation process of the remaining 5 patients in group A3 was similar to that of the typical case of Sun, as shown in Table 2. After 1 week, the patient's pain was relieved, and physical examination showed that the local swelling was relieved, the tenderness was significantly reduced, the activity was still limited, the skin lines were present, the blister was slightly oozing, the edge was slightly red and swollen, and the unbroken blister was absorbed and formed a local scab. After 2 weeks, the patient's pain was significantly improved, and physical examination showed that the limb was slightly swollen, the tenderness was slight, the skin lines were present, the activity was slightly limited, the edge was slightly red and swollen, and the blister was scabbed. After 3 weeks, the patient had no pain, and physical examination showed that there was no obvious swelling, no obvious tenderness, slight limitation of activity, and scabbed blisters. After 4 weeks, the patient had no pain, and physical examination showed that there was no swelling, no obvious tenderness, no obvious limitation of activity, and scabbed blisters.

[0129] Group A4 (Comparative Example B3)

[0130] In group A4, 6 cases were treated with Comparative Example B3, and the typical case observation process was as follows:

[0131] Liu, female, 28 years old, 1 day ago, fell on the right wrist, and had right wrist swelling and pain, deformity. She went to the local emergency department for treatment, and DR examination showed that the right distal radius was fractured. The patient was treated with plaster fixation. After 1 day, water blisters, local skin damage, and oozing occurred at the plaster fixation site. The patient went to the orthopedic clinic of our hospital, and after the plaster was removed, the right upper limb was found to be obviously swollen, the local tenderness was obvious, the activity was limited, the skin lines of the affected limb disappeared, the skin was tight and shiny, multiple water blisters were found at the fracture site, the edge was red and swollen, and the largest water blister was about 2 cm*2 cm. The water blisters had broken, the base was red, and yellow liquid flowed out. The diagnosis was tension blisters after right distal radius fracture. Modified black bean yarn was applied externally, and the patient was advised to elevate the affected limb. The dressing was changed after 1 week.

[0132] 1 week later: The patient's right upper limb pain was less than before, and the plaster was in place. Physical examination showed that the local swelling of the right upper limb was relieved, the tenderness was significantly reduced, the activity was still limited, the skin lines of the affected limb existed, the water blisters of the broken part slightly leaked, the edge was slightly red and swollen, the water blisters of the unbroken part were absorbed, and local scab formation. Change medicine, continue to apply flavored black bean yarn, change medicine after 1 week.

[0133] 2 weeks later: The patient's right upper limb pain was significantly improved, and the plaster was in place. Physical examination showed that the right upper limb was slightly swollen, with light tenderness, the skin lines of the affected limb existed, the activity was slightly limited, the edge was slightly red and swollen, and the water blisters were scabbed. Change medicine, continue to apply flavored black bean yarn, change medicine after 1 week.

[0134] 3 weeks later: The patient's right upper limb had no pain, and the plaster was in place. Physical examination showed that the right upper limb had no obvious swelling, the tenderness was not obvious, the activity was slightly limited, the water blisters were scabbed, and the local scab fell off. Change medicine, continue to apply flavored black bean yarn, change medicine after 1 week.

[0135] 4 weeks later: The patient's right upper limb had no pain, and the plaster was in place. Physical examination showed that the right upper limb had no swelling, no obvious tenderness, and no obvious activity limitation, and the water blisters were scabbed and fell off. Remove the plaster, and advise the patient to rest, bear weight appropriately, and do functional exercise properly, without intense exercise.

[0136] The case observation process of the remaining 5 patients in group A4 was similar to that of the typical case Liu, as shown in Table 2. After 1 week, the patient's pain was less than before, and the physical examination showed that the local swelling of the affected limb was relieved, the tenderness was significantly reduced, the activity was still limited, the skin lines of the affected limb existed, the water blisters of the broken part slightly leaked, the edge was slightly red and swollen, the water blisters of the unbroken part were absorbed, and local scab formation. After 2 weeks, the patient's pain was significantly improved, and the physical examination showed that the affected part was slightly swollen, with light tenderness, the skin lines of the affected limb existed, the activity was slightly limited, the edge was slightly red and swollen, and the water blisters were scabbed. After 3 weeks, the patient had no pain, and the physical examination showed that the affected part had no obvious swelling, the tenderness was not obvious, the activity was slightly limited, the water blisters were scabbed, and the local scab fell off. After 4 weeks, the patient had no pain, and the physical examination showed that the affected part had no swelling, no obvious tenderness, and no obvious activity limitation, and the water blisters were scabbed and fell off.

[0137] Group A5 (Comparative Example B3)

[0138] The 6 cases in group A5 used Comparative Example B4, and the typical case observation process was as follows:

[0139] Zhang, male, 35 years old, 1 day ago was accidentally hit by an electric car left hand, namely left wrist swelling, deformity, to our hospital emergency treatment, DR examination showed: left distal radius fracture, after routine manual reduction with small splint fixation treatment. 1 day later, the splint fixation appeared blisters, local skin damage, exudation, to our hospital orthopedic clinic, after removing the splint, see: left upper limb local swelling, local tenderness, limited activity, skin lines disappear, skin taut, blisters, edge redness, clear yellow transparent liquid, the largest about 2 cm*3 cm, multiple blisters have broken, the base of red, with yellow liquid outflow. Diagnosis: left distal radius fracture after tension blisters. With the addition of black bean yarn, continue to use the splint fixation, the patient is advised to pay attention to elevate the affected limb, 1 week later dressing change.

[0140] 1 week after recheck: the patient's left upper limb pain than before, splint fixation in place. Physical examination showed: left upper limb local swelling than before ease, tenderness than before significantly reduced, activity is still limited, the presence of skin lines, broken blisters slightly exudation, edge redness, unbroken water blisters absorption, local scab formation. Dressing change, continue to use the addition of black bean yarn, 1 week later dressing change.

[0141] 2 weeks after recheck: the patient's left upper limb pain than before significantly improved, splint fixation in place. Physical examination showed: left upper limb slightly swollen, light tenderness, the presence of skin lines, activity slightly limited, edge slightly red and swollen, blisters are scabbed. Dressing change, continue to use the addition of black bean yarn, 1 week later dressing change.

[0142] 3 weeks after recheck: the patient's left upper limb no pain, splint fixation in place. Physical examination showed: left upper limb no obvious swelling, tenderness is not obvious, activity slightly limited, blisters are scabbed, local scab off. Dressing change, continue to use the addition of black bean yarn, 1 week later dressing change.

[0143] 4 weeks after recheck: the patient's left upper limb no pain, splint fixation in place. Physical examination showed: left upper limb no swelling, no obvious tenderness, activity no obvious limited, blisters are scabbed off. Remove the splint treatment, the patient is advised to rest, appropriate weight, appropriate function exercise, do not exercise.

[0144] The case observation process of the remaining 5 patients in Group A5 is similar to that of the typical case of Zhang, as shown in Table 2. After 1 week, the patient returned for a follow-up visit and reported that the pain in the affected area had decreased. Physical examination revealed that the local swelling had improved, and the tenderness had significantly decreased. The patient still had limited mobility, and the skin markings on the affected limb were still present. The blisters on the broken skin had slightly oozed, and the edges were red and swollen. The blisters on the unbroken skin had absorbed, and local scab formation had occurred. After 2 weeks, the patient returned for a follow-up visit and reported that the pain in the affected area had significantly improved. Physical examination revealed that the affected area was slightly swollen, and the tenderness was mild. The skin markings on the affected limb were still present, and the mobility was slightly limited. The edges were slightly red and swollen, and the blisters had all scabbed over. After 3 weeks, the patient returned for a follow-up visit and reported that there was no pain in the affected area. Physical examination revealed that there was no significant swelling or tenderness, and the mobility was slightly limited. The blisters had all scabbed over, and the local scabs had fallen off. After 4 weeks, the patient returned for a follow-up visit and reported that there was no pain in the affected area. Physical examination revealed that there was no swelling or tenderness, and the mobility was not significantly limited. The blisters had all scabbed over and fallen off.

[0145] Group A6 (Comparative Example B5)

[0146] The 6 patients in Group A6 used Comparative Example B5, which was applied externally as a liniment. The typical case observation process is as follows:

[0147] Wang, a 30-year-old woman, fell off her electric bike and hit her right hand 1 day ago, causing swelling and pain in the right upper limb. There was no skin damage, so she went to the emergency department of our hospital for treatment. DR examination showed that the distal radius of the right hand was fractured. The patient was treated with emergency routine manipulation and plaster fixation. This morning, the patient's pain in the plaster fixation area gradually increased, and there was a little oozing on the local gauze. She went to the orthopedic clinic for treatment. After the plaster was removed, it was found that the right upper limb was significantly swollen, and the local tenderness was obvious. The mobility was limited, and the skin markings on the affected limb had disappeared. The skin was tight and shiny, and multiple blisters were found on the fracture site. The edges were red and swollen, and the blisters contained a clear yellow liquid. The largest blister was about 2 cm x 3 cm. Multiple blisters had broken, and the base was red with a yellow liquid flowing out. Diagnosis: Post-fracture tension blisters on the distal radius of the right hand. After routine alcohol disinfection, the blisters were broken with a syringe needle to drain the water, and the liniment was applied externally. The patient was advised to elevate the affected limb, and the dressing was changed after 1 week.

[0148] After 1 week, the patient returned for a follow-up visit and reported that the pain in the right upper limb had significantly improved. The plaster fixation was in place. Physical examination revealed that the local swelling in the right upper limb had improved, and the tenderness had decreased. The mobility was still limited, and the skin markings on the affected limb were still present. The oozing from the broken blisters had decreased, and local granulation tissue had formed. The edges were red, and the unbroken blisters had absorbed. The blister walls were wrinkled. The dressing was changed, and the liniment was continued to be applied externally. The dressing was changed after 1 week.

[0149] After 2 weeks, the patient returned for a follow-up visit and reported that the pain in the right upper limb was not significant. The plaster fixation was in place. Physical examination revealed that the local swelling in the right upper limb had significantly improved, and the tenderness was mild. The mobility had improved, and the skin markings on the affected limb were still present. The broken blisters had no oozing, and the edges were not red and swollen. The unbroken blisters had absorbed, and local scab formation had occurred. The dressing was changed, and the liniment was continued to be applied externally. The dressing was changed after 1 week.

[0150] Week 3: The patient had no obvious pain in the right upper limb, and the plaster was in place. Physical examination showed that the right upper limb was slightly swollen, with light tenderness, and slightly limited movement. The blisters were scabbed. The dressing was changed, and the liniment was continued to be applied externally. The dressing was changed again after 1 week.

[0151] Week 4: The patient had no pain in the right upper limb, and the plaster was in place. Physical examination showed that the right upper limb had no obvious swelling, no tenderness, and no obvious limitation of movement. The blisters were scabbed. The plaster was removed, and the patient was advised to rest, to bear weight appropriately, and to perform functional exercise, but not to perform strenuous exercise.

[0152] The case observation processes of the remaining 5 patients in Group A6 were similar to that of the typical case of Wang, as shown in Table 2. After 1 week, the patients had obvious relief of pain, and physical examination showed that the local swelling was relieved, the tenderness was reduced, the movement was still limited, the skin lines were present, the blisters of the broken skin were reduced, the local granulation tissue was generated, the edge was red, the unbroken skin blisters were absorbed, and the blister wall was wrinkled. After 2 weeks, the patients had no obvious pain, and physical examination showed that the local swelling was obviously improved, there was slight tenderness, the movement limitation was reduced, the skin lines were present, the blisters of the broken skin had no exudation, the edge had no redness and swelling, the unbroken skin blisters were absorbed, and the local scab was formed. After 3 weeks, the patients had no obvious pain, and physical examination showed that the affected area was slightly swollen, with light tenderness, and slightly limited movement. The blisters were scabbed. After 4 weeks, the patients had no pain, and physical examination showed that the affected area had no obvious swelling, no tenderness, and no obvious limitation of movement. The blisters were scabbed.

[0153] Table 2

[0154]

[0155]

[0156] As shown in the recovery of the cases in Groups A1 to A6, the recovery of the patients in Group A1 applying the liniment of Example B1 was obviously better than that of the patients in Groups A2 to A5, and the recovery of the patients in Groups A2 to A5 was better than that of the patients in Group A6. For example, after 1 week, the patients in Group A1 had obvious relief of pain, the blisters of the broken skin had no exudation, the edge was slightly red and swollen, the unbroken skin blisters were absorbed, and the blisters were scabbed. During the recovery process, no granulation tissue was generated. The patients in Groups A2 to A5 had skin lines in the affected limb after 1 week, the blisters of the broken skin had slight exudation, the edge was red and swollen, the unbroken skin blisters were absorbed, and the local scab was formed. After 3 weeks, the blisters were scabbed. The patients in Group A6 had skin lines in the affected limb after 1 week, the blisters of the broken skin had reduced exudation, the local granulation tissue was generated, the edge was red, the unbroken skin blisters were absorbed, and the blister wall was wrinkled. After 2 weeks, the scab was formed. After 3 weeks, the blisters were scabbed. Moreover, the blisters and nodules were not completely shed within 4 weeks.

[0157] The recovery status of patients in Group A1 to Group A6 shows that the traumatic oil gauze in the embodiment of the present application effectively enhances the efficacy of the traumatic composition in promoting blood circulation, removing blood stasis, reducing swelling and relieving pain through the synergistic effect between black bean oil and the oil extracts of various Chinese medicinal materials, and has the efficacy of promoting the repair of damaged skin associated with traumatic injuries and reducing the occurrence of allergic reactions.

[0158] The case observations of patients in groups B1 to B4 were similar to those in group A1, indicating that changing the dosage of Chinese medicinal materials within the scope of the examples of the present application can enhance the mutual effect between black soybean oil and the oil extracts of various Chinese medicinal materials.

[0159] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. A traumatic injury composition, characterized in that: The compound extract obtained by extracting black soybean oil is used as the active ingredient, and the compound extract is prepared from the following Chinese medicinal materials in parts by weight: 80-120 parts of Pinellia ternata, 80-120 parts of processed Aconitum kusnezoffii, 80-120 parts of processed Rhizoma Aconiti Kusnezoffii, 80-120 parts of processed Rhizoma Aconiti Kusnezoffii, 80-120 parts of Radix Ginseng, 80-120 parts of Saposhnikovia divaricata, 40-60 parts of Borneolum Syndrome, 40-60 parts of Carthamus tinctorius, 80-120 parts of Dipsacus asper, 80-120 parts of Paris polyphylla, 40-60 parts of Rhizoma Xanthophyllae, 80-120 parts of Salix leucoderma leaves, and 40-60 parts of Scutellaria baicalensis.

2. The traumatic injury composition according to claim 1, wherein The weight parts of the Chinese medicinal materials are as follows: 90-110 parts of Rhizoma Pinelliae Rhizoma, 90-110 parts of processed Radix Aconiti Kusnezoffii, 90-110 parts of processed Rhizoma Arisaematis, 90-110 parts of processed Radix Aconiti Kusnezoffii, 90-110 parts of Radix Ginseng, 90-110 parts of Saposhnikoviae Saposhnikoviae, 45-55 parts of Borneolum Syndrome, 45-55 parts of Carthamus Tinctorius, 90-110 parts of Dipsacus Asper, 90-110 parts of Paris Polygoni Multiflori, 45-55 parts of Rhizoma Xanthophyllae, 90-110 parts of Folium Ligusticum Wallichii, and 45-55 parts of Radix Scutellariae.

3. The traumatic injury composition according to claim 2, wherein: The weight parts of the Chinese medicinal materials are as follows: 100 parts of Rhizoma Pinelliae Rhizoma, 100 parts of processed Radix Aconiti Kusnezoffii, 100 parts of processed Rhizoma Arisaematis, 100 parts of processed Radix Aconiti Lateralis Preparata, 100 parts of Radix Ginsengs, 100 parts of Saposhnikoviae Radix, 50 parts of Borneolum Syntheticum, 50 parts of Flos Carthami, 100 parts of Radix Dipsaci, 100 parts of Rhizoma Parispinii, 50 parts of Radix Phellodendri, 100 parts of Folium Ligusticum Wallichii, and 50 parts of Radix Scutellariae.

4. The traumatic injury composition according to any one of claims 1 to 3, characterized in that: The traumatic injury composition comprises black soybean oil, and each 1 kg of the black soybean oil contains 400 g to 500 g of the compound extract.

5. The method for preparing the compound extract according to any one of claims 1 to 4, wherein: The steps include: Provide prescription quantities of Chinese herbal medicines; The Chinese medicinal materials are subjected to oil-roasting treatment using black bean oil, followed by soaking treatment to obtain a mixture containing medicinal residues; The mixture is subjected to solid-liquid separation, and the medicinal residue is removed to obtain a compound extract.

6. The preparation method according to claim 5, wherein The oil-roasting treatment satisfies at least one of the following (1) to (3): (1) Temperature is 200-230°C; (2) After the oil-roasting treatment, the surface of the wooden Chinese medicinal material is carbonized and the interior is brown; (3) The oil roasting process is carried out in a ceramic container.

7. The preparation method according to claim 5 or 6, characterized in that The soaking treatment is performed at a temperature of 10 to 30° C. and for a time of 30 to 45 days.

8. The preparation method according to claim 5 or 6, characterized in that A stirring process is also performed during the soaking process.

9. The preparation method according to claim 5 or 6, characterized in that: The soaking treatment is carried out in a ceramic container.

10. The preparation method according to claim 5 or 6, characterized in that: During the oil-roasting process, the black bean oil and the Chinese medicinal materials are mixed in the following mass ratios to obtain: The mass ratio of the total mass of the Chinese medicinal materials to the black soybean oil is 11:(23-25).

11. The preparation method according to claim 5 or 6, characterized in that: Before the oil-roasting process, the method further comprises the following steps: The Chinese medicinal materials are soaked and moistened with water, and the water-soaked Chinese medicinal materials are subjected to a water bath treatment to obtain moistened Chinese medicinal materials.

12. A traumatic injury gauze, characterized in that: The traumatic injury composition according to any one of claims 1 to 4 is loaded on a fiber carrier as an effective component to prepare an oil yarn.

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