An oil-controlling and acne-removing raw material composition, a preparation method and application thereof

Abstract

The present application relates to a kind of oil control acne raw material composition, preparation method and its application, composition includes the following components according to concentration percentage: 70%-80% hydroxyapatite, 5%-15% salicylic acid, 6%-6.5% amylopectin, 3%-7% dextrin and 2.75%-4.75% xanthan gum.The preparation method of composition includes the following steps: step 1, preparation SA-200, salicylic acid solution is mixed with dextrin aqueous solution, and linear amylopectin and xanthan gum are added to the mixed solution, ultrasonic treatment 10min, after 120min stationary SA-200 solution is obtained;Step 2, preparation hydroxyapatite aqueous solution;Step 3, using hydroxyapatite embedding SA-200, SA-200 solution is mixed with hydroxyapatite aqueous solution, ultrasonic treatment 10min, after 120min stationary oil control acne raw material composition is obtained.It is by using hydroxyapatite as carrier, carries out secondary embedding treatment, aims at improving the light stability of salicylic acid, the stability in cosmetics, improves skin feeling and enhances the oil control performance to skin.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a composition of an oil-controlling and acne-removing raw material, a preparation method and application thereof. BACKGROUND

[0002] Salicylic acid, as a widely used ingredient in cosmetics, has significant antibacterial, acne-removing and oil-controlling functions. However, traditional salicylic acid has a series of problems in application, including difficulty in dissolving in water, high skin irritation, narrow pH application range and poor light stability.

[0003] In the prior art, a Chinese patent with publication number CN114028265A discloses a supermolecular embedded salicylic acid and a preparation method thereof. The supermolecular embedded salicylic acid includes 35% salicylic acid, 45% dextrin and 20% sesame amino acid in terms of concentration percentage. The dextrin is a supermolecular cyclodextrin. The preparation method of the supermolecular embedded salicylic acid includes the following steps: (1) preparing a salicylic acid solution; (2) preparing a dextrin aqueous solution; (3) preparing a sesame amino acid aqueous solution; (4) mixing the salicylic acid solution, the dextrin aqueous solution and the sesame amino acid aqueous solution, at this time the concentration percentages of salicylic acid, dextrin and sesame amino acid in the mixed aqueous solution are 35%, 45% and 20% respectively, ultrasonic treatment for 5 min, and standing for 90 min to obtain a supermolecular embedded salicylic acid solution.

[0004] The prior art in the above has the following defects: although the salicylic acid wrapped by dextrin (SA-200) in the above solves the solubility problem to some extent, it still cannot fully solve the above challenges. Traditional salicylic acid is difficult to dissolve in water, and needs to be neutralized into sodium salicylate with NaOH first, and then reversed to weak acid conditions. The salicylic acid wrapped by dextrin (SA-200) solves the problem of poor solubility of salicylic acid, but at the same time, it also has problems such as easy discoloration under light, precipitation under acidic conditions and sticky skin feel. For example, the pH application range is relatively narrow, there is a risk of precipitation when the system pH is lower than 4.0, and the stability is poor, the salicylic acid solution will turn yellow under long-term light conditions, thereby causing the problems of cosmetic and sticky skin feel. SUMMARY

[0005] In view of the deficiencies of the prior art, the purpose of the present application is to provide a composition of an oil-controlling and acne-removing raw material, a preparation method and application thereof, which uses hydroxyapatite as a carrier and carries out secondary embedding treatment, aiming to improve the light stability and stability in cosmetics of salicylic acid, improve the skin feel and enhance the oil-controlling performance on the skin. The hydroxyapatite forms a cavity structure to embed SA200 inside, thereby effectively protecting and releasing the salicylic acid, improving the application effect and user experience of the salicylic acid in skin care products.

[0006] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0007] A composition of oil-controlling and acne-removing raw materials comprises the following components, calculated by concentration percentage: 70%-80% of hydroxyapatite, 5%-15% of salicylic acid, 6%-6.5% of amylopectin, 3%-7% of dextrin, and 2.75%-4.75% of xanthan gum.

[0008] As a further technical solution of the present invention: the following components are included in terms of concentration percentage: 75% hydroxyapatite, 10% salicylic acid, 6.25% pullulan, 5% dextrin and 3.75% xanthan gum.

[0009] The method for preparing the above-mentioned composition of oil-controlling and acne-removing raw materials comprises the following steps:

[0010] Step 1: Prepare SA-200 by mixing a salicylic acid solution with a dextrin aqueous solution, and adding amylose and xanthan gum to the mixture. The concentrations of salicylic acid, amylopectin, dextrin, and xanthan gum in the mixed aqueous solution are 35%-45%, 20%-30%, 15%-25%, and 10%-20%, respectively. Ultrasonic treatment is performed for 10 minutes, and the mixture is allowed to stand for 120 minutes to obtain a SA-200 solution.

[0011] Step 2, preparing a hydroxyapatite aqueous solution;

[0012] Step 3: Using hydroxyapatite to embed SA-200, the SA-200 solution is mixed with the hydroxyapatite aqueous solution, wherein the concentration percentages of SA-200 and hydroxyapatite in the mixed aqueous solution are 20%-30% and 70%-80%, respectively. The mixture is ultrasonically treated for 10 minutes and allowed to stand for 120 minutes to obtain a composition of oil-controlling and acne-removing raw materials.

[0013] As a further technical solution of the present invention: in step 1, the concentration percentages of salicylic acid, pullulan, dextrin and xanthan gum in the mixed aqueous solution are 40%, 25%, 20% and 15% respectively.

[0014] As a further technical solution of the present invention, it is characterized in that, in step 3, the concentration percentages of SA-200 and hydroxyapatite in the mixed aqueous solution are 25% and 75% respectively.

[0015] For example, the use of a composition of oil-controlling and acne-removing raw materials in the preparation of skin care products for improving acne-prone skin and oil-controlling skin care products.

[0016] For example, the use of the above-mentioned composition of oil-controlling and acne-removing raw materials in the preparation of anti-aging and anti-wrinkle skin care products or cosmetics.

[0017] For example, the use of the above-mentioned composition of oil-controlling and acne-removing raw materials in the preparation of skin-rejuvenating and brightening skin care products or cosmetics.

[0018] For example, the use of the above-mentioned composition of oil-controlling and acne-removing raw materials in the preparation of whitening and spot-lightening skin care products or cosmetics.

[0019] For example, the use of the above-mentioned composition of oil-controlling and acne-removing raw materials in the preparation of skin care products or cosmetics for improving the skin barrier.

[0020] In summary, the present invention includes at least one of the following beneficial technical effects:

[0021] 1. The present invention discloses a composition, preparation method, and application of an oil-control and acne-removing raw material. Using hydroxyapatite as a carrier and undergoing a secondary encapsulation treatment, the composition aims to improve the photostability and cosmetic stability of salicylic acid, enhance skin feel, and enhance its oil-control properties. Hydroxyapatite forms a cavitated structure, encapsulating SA200 within it, effectively protecting and sustaining the release of salicylic acid, enhancing its application effectiveness and user experience in skincare products.

[0022] 2. The pH stability and salicylic acid precipitation tests conducted in this invention are expected to demonstrate the excellent stability of hydroxyapatite-encapsulated SA200 in acidic conditions, significantly reducing salicylic acid precipitation. This encapsulation technology effectively enhances the potential for salicylic acid applications in low-pH environments, providing new possibilities for the development of cosmetics for sensitive skin.

[0023] 3. In photostability testing, hydroxyapatite-encapsulated SA200 is expected to exhibit low photosensitivity and excellent color retention. This demonstrates that this technology can effectively resist UV-induced chemical degradation, extend the shelf life of the product, and maintain the stability of its active ingredients.

[0024] 4. Testing of the texture, skin feel, and stability of the present formulation is expected to demonstrate that hydroxyapatite-encapsulated SA200 provides superior skin feel and user experience in cosmetic formulations while maintaining formulation stability. In particular, actual user evaluation is expected to demonstrate significant advantages over traditional salicylic acid products in terms of oil control and anti-acne effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 The figure is a statistical comparison of pH changes of the composition of the present invention, standard salicylic acid and SA-200 after being placed for 28 days at a test pH of 2.

[0026] Figure 2 The figure is a statistical comparison of pH changes of the composition of the present invention, standard salicylic acid and SA-200 after being placed at a test pH of 3 for 28 days.

[0027] Figure 3 The figure is a statistical comparison of pH changes of the composition of the present invention, standard salicylic acid and SA-200 after being placed for 28 days at a test pH of 4.

[0028] Figure 4 This is a statistical chart comparing the pH changes of the composition of the present invention, standard salicylic acid, and SA-200 when the pH value is 5 for 28 days.

[0029] Figure 5 The figure is a statistical comparison of the salicylic acid content in the filtrate of the composition of the present invention, standard salicylic acid and SA-200 after being placed for 28 days at a test pH of 2.

[0030] Figure 6 The figure is a statistical comparison of the salicylic acid content in the filtrate of the composition of the present invention, standard salicylic acid and SA-200 after being placed for 28 days at a test pH of 3.

[0031] Figure 7 The figure is a statistical comparison of the salicylic acid content in the filtrate of the composition of the present invention, standard salicylic acid and SA-200 after being placed for 28 days at a test pH of 4.

[0032] Figure 8 The figure is a statistical comparison of the salicylic acid content in the filtrate of the composition of the present invention, standard salicylic acid and SA-200 after being placed for 28 days at a test pH of 5.

[0033] Figure 9 This is a color change trend diagram of standard salicylic acid after being irradiated by UV light in the experimental example of the present invention.

[0034] Figure 10 This is a color change trend diagram of SA-200 after being irradiated by UV light in the experimental example of the present invention.

[0035] Figure 11 This is a color change trend diagram of the hydroxyapatite-embedded salicylic acid composition in the experimental example of the present invention after being irradiated by UV light. DETAILED DESCRIPTION

[0036] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application; it is obvious that the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0037] Example 1:

[0038] A composition of oil-controlling and acne-removing raw materials comprises the following components, calculated by concentration percentage: 75% of hydroxyapatite, 10% of salicylic acid, 6.25% of amylopectin, 5% of dextrin and 3.75% of xanthan gum.

[0039] The method for preparing the above-mentioned composition of oil-controlling and acne-removing raw materials comprises the following steps:

[0040] Step 1: Prepare SA-200 by mixing a salicylic acid solution with a dextrin aqueous solution, and adding amylose and xanthan gum to the mixture. The concentrations of salicylic acid, amylopectin, dextrin, and xanthan gum in the mixed aqueous solution are 40%, 25%, 20%, and 15%, respectively. Ultrasonic treatment is performed for 10 minutes, and the mixture is allowed to stand for 120 minutes to obtain a SA-200 solution.

[0041] Step 2, preparing a hydroxyapatite aqueous solution;

[0042] Step 3: SA-200 is embedded in hydroxyapatite, and the SA-200 solution is mixed with the hydroxyapatite aqueous solution. At this time, the concentration percentages of SA-200 and hydroxyapatite in the mixed aqueous solution are 25% and 75%, respectively. The mixture is ultrasonically treated for 10 minutes and allowed to stand for 120 minutes to obtain a composition of oil-controlling and acne-removing raw materials.

[0043] In this embodiment, the specific formula of the composition of oil-controlling and acne-removing raw materials is shown in Table 1:

[0044] Table 1

[0045]

[0046] Example 2:

[0047] A composition of oil-controlling and acne-removing raw materials comprises the following components, calculated by concentration percentage: 80% of hydroxyapatite, 8% of salicylic acid, 6% of amylopectin, 3% of dextrin, and 3% of xanthan gum.

[0048] The method for preparing the above-mentioned composition of oil-controlling and acne-removing raw materials comprises the following steps:

[0049] Step 1: Prepare SA-200 by mixing a salicylic acid solution with a dextrin aqueous solution, and adding amylose and xanthan gum to the mixture. The concentrations of salicylic acid, amylopectin, dextrin, and xanthan gum in the mixed aqueous solution are 45%, 30%, 15%, and 10%, respectively. Ultrasonic treatment is performed for 10 minutes, and the mixture is allowed to stand for 120 minutes to obtain a SA-200 solution.

[0050] Step 2, preparing a hydroxyapatite aqueous solution;

[0051] Step 3: SA-200 is embedded in hydroxyapatite, and the SA-200 solution is mixed with the hydroxyapatite aqueous solution. At this time, the concentration percentages of SA-200 and hydroxyapatite in the mixed aqueous solution are 20% and 80%, respectively. The mixture is ultrasonically treated for 10 minutes and allowed to stand for 120 minutes to obtain a composition of oil-controlling and acne-removing raw materials.

[0052] Example 3:

[0053] A composition of oil-controlling and acne-removing raw materials comprises the following components, calculated by concentration percentage: 70% hydroxyapatite, 12% salicylic acid, 6.5% amylopectin, 7% dextrin and 4.5% xanthan gum.

[0054] The method for preparing the above-mentioned composition of oil-controlling and acne-removing raw materials comprises the following steps:

[0055] Step 1: Prepare SA-200 by mixing a salicylic acid solution with a dextrin aqueous solution, and adding amylose and xanthan gum to the mixture. The concentrations of salicylic acid, amylopectin, dextrin, and xanthan gum in the mixed aqueous solution are 35%, 30%, 25%, and 10%, respectively. Ultrasonic treatment is performed for 10 minutes, and the mixture is allowed to stand for 120 minutes to obtain a SA-200 solution.

[0056] Step 2, preparing a hydroxyapatite aqueous solution;

[0057] Step 3: SA-200 is embedded in hydroxyapatite, and the SA-200 solution is mixed with the hydroxyapatite aqueous solution. At this time, the concentration percentages of SA-200 and hydroxyapatite in the mixed aqueous solution are 30% and 70%, respectively. The mixture is ultrasonically treated for 10 minutes and allowed to stand for 120 minutes to obtain a composition of oil-controlling and acne-removing raw materials.

[0058] Experimental example:

[0059] This R&D project designed three sets of experiments to verify the improved performance of salicylic acid using hydroxyapatite-encapsulated technology. In practical applications, the oil-control and acne-removing raw material composition and preparation method described in Example 1 were preferred. These included testing the salicylic acid's release under acidic conditions, stability under light, and texture, skin feel, and stability within the formulation. The expected results showed that the hydroxyapatite-encapsulated SA200 formulation exhibited superior performance in all tests compared to traditional salicylic acid and SA200.

[0060] In order to supplement the “Experimental Design and Expected Results” section in detail, we will delve into the specific experimental methods and expected results of hydroxyapatite-embedded salicylic acid (SA200).

[0061] Experimental design:

[0062] Experiment 1: pH stability and salicylic acid release test Purpose: To evaluate the release behavior and stability of SA200 embedded in hydroxyapatite under different acidic conditions. Method:

[0063] 1. Prepare three samples: pure salicylic acid solution, SA200 aqueous solution, and SA200 aqueous solution embedded in hydroxyapatite (HAPS in the figure). Ensure that the mass fraction of salicylic acid in the three samples is equal.

[0064] 2. Set the pH gradient: 2.0, 3.0, 4.0, 5.0, and use a pH meter to accurately adjust the pH value of the sample solution.

[0065] 3. Place in a constant temperature light-proof condition (25°C) for 30 days, and regularly sample to analyze the release amount of salicylic acid and the change of sample pH.

[0066] 4. Use high performance liquid chromatography (HPLC) to analyze the salicylic acid concentration in the sample at each time point.

[0067] Figures 1 to 4 The actual salicylic acid content of the configuration solution is 0.5%, and other additives: citric acid (analytical pure) and sodium citrate (analytical pure), anhydrous ethanol (analytical pure), primary purified water.

[0068] Conclusion: Referring to Figures 1-4 From the above four figures, it can be analyzed that the SA200 embedded in hydroxyapatite can maintain a good stable state between pH 2-5 during the test, while SA-200 combined Figure 1-Figure 3 It can be found that part of the salicylic acid is released, i.e. the structure is destroyed.

[0069] Considering the actual application, the method of determining the content of salicylic acid by high performance liquid chromatography is in accordance with the "Cosmetic Safety Technical Specification" 2015 edition Chapter IV Physicochemical test method limited component test method.

[0070] Electronic balance: LE204E type, graduation value is 0.0001g, Switzerland Mettler-Toledo Group.

[0071] Salicylic acid: purity is 99.3%, Sigma Aldrich (Shanghai) Trading Co., Ltd.

[0072] MCE membrane filter, Sigma Aldrich (Shanghai) Trading Co., Ltd.

[0073] Water for experiment: primary purified water. Methanol, chromatographic pure. Phosphoric acid, chromatographic pure. Ammonia water, chromatographic pure, content 25.0%.

[0074] Methanol aqueous solution: methanol + water (3:1).

[0075] SK5200HP type table ultrasonic cleaner.

[0076] Digital vortex shaker, Thermo Fisher Scientific.

[0077] Chromatographic conditions Chromatographic column: acid-resistant C8 column (150 mm x 4.6 mm, 5 μm) Dikma;

[0078] SPD-M20A diode array detector, Shimadzu, Japan.

[0079] Preparation of mobile phase: ① Phosphoric acid solution: 11.5 g of phosphoric acid was weighed to 0.01 g, 950 mL of water was added, and the pH was adjusted to 2.3-2.5 with ammonia water, and then water was added to 1000 mL. ② Mobile phase A solution: 200.0 mL of the phosphoric acid solution was measured and diluted to 1000 mL with water. ③ Mobile phase B solution: 250.0 mL of the phosphoric acid solution was measured and diluted to 1000 mL with methanol. The gradient elution program of the mobile phase is shown in Table 2. The flow rate was 1.2 mL·min-1, the column temperature was 25 °C, and the injection volume was 10 μL.

[0080] Table 2 Gradient elution program of mobile phase

[0081]

[0082]

[0083] Salicylic acid standard stock solution (ρ = 1.0 g·L-1): 0.05 g of salicylic acid was weighed to 0.0001 g in a 50 mL brown volumetric flask, dissolved with methanol water solution and diluted to 50 mL, to obtain a salicylic acid standard stock solution with a mass concentration of 1 mg·mL-1.

[0084] Gradient series concentration salicylic acid standard solution: a series of salicylic acid standard working solutions with mass concentrations of 5 μg·mL-1, 50 μg·mL-1, 100 μg·mL-1, 150 μg·mL-1 and 200 μg·mL-1 were prepared.

[0085] Sample treatment: 0.25 g of sample was weighed to 0.001 g and placed in a 25 mL colorimetric tube with a stopper, 20 mL of methanol water solution (methanol: water = 75:25) was added, vortexed for 60 s, uniformly dispersed, ultrasonically extracted (power: 400 W) for 15 min, cooled to room temperature, diluted to the 25 mL mark with methanol water solution, vortexed and shaken, filtered the mixture, the filtrate was diluted with methanol water solution as needed, and stored in a 2 mL brown sample bottle as a sample solution to be tested.

[0086] Determination:

[0087] According to the above chromatographic conditions, a series of salicylic acid standard solutions were injected separately, and the content of salicylic acid was calculated based on the calculated regression equation.

[0088] =(A 样 -intercept)÷slope R 2 =(0.9998)

[0089] ω=(D×ρ×V×100)÷(m×10 6 )

[0090] Where: ω——mass fraction of salicylic acid in cosmetics, %;

[0091] D——sample dilution factor (1 if not diluted);

[0092] ρ——mass concentration of salicylic acid obtained from standard solution, g / mL;

[0093] V——sample volume, mL;

[0094] m——sample sampling volume, g.

[0095] The obtained data are made into a bar graph, refer to Figure 5-Figure 8 .

[0096] Conclusion: From Figure 5-Figure 8 It can be seen that the structure of salicylic acid embedded in hydroxyapatite is stable, the content of non-ionized salicylic acid in the sample determination is high, and the pH tolerance is wide, which is better than ordinary salicylic acid and SA-200.

[0097] Expected effects: Hydroxyapatite-encapsulated SA200 is expected to show lower salicylic acid precipitation and higher stability at low pH values ​​compared with pure salicylic acid and SA200 aqueous solution.

[0098] Experiment 2: Photostability test Purpose: To evaluate the photoprotective effect of hydroxyapatite-encapsulated SA200 against salicylic acid.

[0099] method:

[0100] 1. Prepare the same three samples as in Experiment 1 and place them under a UV lamp to simulate sunlight.

[0101] 2. Set the experimental period to 28 days, with 8 hours of irradiation per day.

[0102] 3. Take samples every 7 days and observe the color changes of the samples.

[0103] 4. Record data and analyze the effect of hydroxyapatite embedding on the photostability of salicylic acid.

[0104] Test based on Experiment 1:

[0105] Figures 9-11 The results showed that during the test, UV irradiation caused SA-200 and ordinary salicylic acid to have similar discoloration trends, and light had a greater impact. However, the hydroalcoholic solution sample of MAHC hydroxyapatite-embedded salicylic acid had good light stability.

[0106] Expected effect: Hydroxyapatite-encapsulated SA200 is expected to exhibit better photostability and reduce the degradation of salicylic acid under long-term light exposure, with significant differences compared to the control group.

[0107] Experiment 3: Texture, skin feel and stability testing of the formula system (10-15 people)

[0108] Subjective evaluation, oiled probe Purpose: To evaluate the effect of hydroxyapatite-embedded SA200 in actual cosmetic formulations.

[0109] method:

[0110] 1. Add the three samples to the same formula of facial cream to ensure that the final mass fraction of salicylic acid is consistent.

[0111] 2. Conduct stability testing for up to 30 days, including texture observation, pH monitoring, and microbiological testing.

[0112] 3. Organize 10-15 internal testers to conduct blind tests to evaluate the product's skin feel, absorbency, and sensory satisfaction after use.

[0113] 4. Collect usage feedback through questionnaires and conduct statistical analysis.

[0114] Expected effect: The hydroxyapatite-embedded SA200 formula is expected to be superior to traditional salicylic acid and SA200 formulas in terms of skin feel, absorbability and long-term stability, providing a more comfortable and long-lasting usage experience.

[0115] Summarize:

[0116] These three experiments were designed to comprehensively evaluate the improvements made to the hydroxyapatite-encapsulated SA200 technology. Through these experiments, we anticipate gaining a deeper understanding of the technology's impact on the properties of salicylic acid, particularly regarding solubility, stability, and skin feel.

[0117] Analysis of expected experimental results

[0118] 1. pH stability and salicylic acid precipitation testing is expected to demonstrate the excellent stability of hydroxyapatite-encapsulated SA200 in acidic conditions, significantly reducing salicylic acid precipitation. This result will prove that the encapsulation technology effectively enhances the application potential of salicylic acid in low pH environments, providing new possibilities for the development of cosmetics for sensitive skin.

[0119] 2. In photostability testing, hydroxyapatite-encapsulated SA200 is expected to show low photosensitivity and good color retention. This demonstrates that the technology can effectively resist UV-induced chemical degradation, extend the shelf life of the product, and maintain the stability of its active ingredients.

[0120] 3. Texture, skin feel, and stability testing within the formulation system is expected to demonstrate that hydroxyapatite-encapsulated SA200 provides superior skin feel and user experience in cosmetic formulations while maintaining formula stability. In particular, actual user evaluations are expected to demonstrate its significant advantages over traditional salicylic acid products in terms of oil control and anti-acne effects.

[0121] Conclusion and Outlook:

[0122] Through this series of experimental designs and analysis of expected results, the hydroxyapatite-encapsulated SA200 technology is expected to provide a new solution for the cosmetics industry, particularly in products that require improved active ingredient stability and user sensory experience. Furthermore, the successful application of this technology may trigger a new wave of cosmetic formulation innovation, particularly in skincare and therapeutic products that pursue high efficacy and stability.

[0123] Ultimately, the results of these experiments will provide a solid scientific foundation for the commercial application of hydroxyapatite encapsulation technology, helping companies develop a new generation of cosmetic products that are safer, more effective, and offer a better user experience. Further research may explore the application of this technology in different types of cosmetic formulations and how to optimize hydroxyapatite carrier design to achieve the stabilization and controlled release of a wider range of active ingredients.

[0124] Cosmetics Industry Applications: Hydroxyapatite-encapsulated salicylic acid not only improves the effectiveness of salicylic acid but also provides a new material option for the cosmetics industry, particularly suitable for the formulation of acne-prone skincare and oil-control skincare products. Applications include, but are not limited to, anti-aging and wrinkle reduction, skin rejuvenation and brightening, whitening and spot reduction, and skin barrier improvement.

[0125] Conclusion: Hydroxyapatite encapsulation technology offers a new solution for salicylic acid in cosmetic applications, improving stability, enhancing skin feel, and enhancing efficacy, resulting in a superior skincare experience. Future development and application of this technology is expected to have a broad and positive impact in the cosmetics field.

[0126] This patent document outlines the uniqueness, experimental design, efficacy verification, and potential applications of hydroxyapatite-encapsulated salicylic acid technology, aiming to protect and promote this innovative technology. By demonstrating its superiority through carefully designed experiments, further development and application of this technology is expected to broaden its use in a variety of cosmetic formulations, thereby meeting the high standards of efficacy, stability, and safety for diverse consumers of skincare products. Hydroxyapatite-encapsulated technology not only significantly enhances the photostability and chemical stability of salicylic acid, but also optimizes skin feel and release through its unique cavitation structure, making the active ingredient gentler and more long-lasting.

[0127] As consumers increasingly focus on the safety and effectiveness of cosmetic ingredients and pursue innovative, high-performance products, this technology offers a high-value solution for the cosmetics industry. In particular, in areas such as anti-acne, oil control, and anti-aging, the application of hydroxyapatite-encapsulated salicylic acid can meet market demands for an effective, safe, and comfortable skincare experience.

[0128] Furthermore, the development and application of this technology will encourage the cosmetics industry to further explore and utilize the innovative opportunities presented by advanced materials science for traditional ingredients. By further deepening research on the co-encapsulation of hydroxyapatite with other active ingredients, it is possible to develop a series of new, targeted cosmetic formulations, further promoting the development of personalized skincare and precision treatment solutions.

[0129] Ultimately, the commercialization of hydroxyapatite-encapsulated salicylic acid technology will rely on continued R&D investment, market validation, and consumer education. To this end, the preparation of this patent document aims to lay the foundation for the protection, promotion, and future commercial application of this technology. By demonstrating its superiority through carefully designed experiments, this technology is expected to become a major milestone in the cosmetics industry, providing consumers with a safer, more effective, and more enjoyable skincare experience.

[0130] The present invention is based on the following principles: It discloses a composition, preparation method, and application of an oil-control and acne-removing ingredient. Using hydroxyapatite as a carrier and undergoing a secondary encapsulation treatment, the invention aims to improve the photostability and cosmetic stability of salicylic acid, enhance skin feel, and enhance its oil-control properties. Hydroxyapatite forms a porous structure, encapsulating SA200 within it, effectively protecting and sustaining the release of salicylic acid, enhancing its effectiveness and user experience in skincare products.

[0131] The embodiments of this specific implementation method are all preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Therefore, any equivalent changes made based on the structure, shape, and principle of the present invention should be included in the scope of protection of the present invention.

Claims

1. A composition of oil-controlling and acne-removing raw materials, characterized in that: Calculated by concentration percentage, it includes the following components: 70%-80% hydroxyapatite, 5%-15% salicylic acid, 6%-6.5% pullulan, 3%-7% dextrin and 2.75%-4.75% xanthan gum; The preparation method of the composition comprises the following steps: Step 1: Prepare SA-200 by mixing a salicylic acid solution with an aqueous dextrin solution, and adding pullulan and xanthan gum to the mixture. The concentrations of salicylic acid, pullulan, dextrin, and xanthan gum in the mixed aqueous solution are 35%-45%, 20%-30%, 15%-25%, and 10%-20%, respectively. Ultrasonicate for 10 minutes and let stand for 120 minutes to obtain an SA-200 solution. Step 2, preparing a hydroxyapatite aqueous solution; Step 3: Encapsulate SA-200 with hydroxyapatite, mix the SA-200 solution with the hydroxyapatite aqueous solution, wherein the concentration percentages of SA-200 and hydroxyapatite in the mixed aqueous solution are 20%-30% and 70%-80%, respectively. Ultrasonic treatment is performed for 10 minutes, and the mixture is allowed to stand for 120 minutes to obtain a composition of oil-controlling and acne-removing raw materials.

2. The composition of the oil-control and acne-removing raw material according to claim 1, characterized in that: The composition comprises the following components in terms of concentration percentage: 75% hydroxyapatite, 10% salicylic acid, 6.25% pullulan, 5% dextrin and 3.75% xanthan gum.

3. The composition of the oil-controlling and acne-removing raw material according to claim 1, characterized in that: In step 1, the concentration percentages of salicylic acid, pullulan, dextrin and xanthan gum in the mixed aqueous solution are 40%, 25%, 20% and 15%, respectively.

4. The composition of oil-controlling and acne-removing raw materials according to any one of claims 1 to 3, characterized in that: In step 3, the concentration percentages of SA-200 and hydroxyapatite in the mixed aqueous solution are 25% and 75%, respectively.

5. The use of a composition of oil-controlling and acne-removing raw materials according to any one of claims 1 to 2, characterized in that: The above composition is used in the preparation of skin care products for improving acne skin and oil-controlling skin care products.

6. The use of a composition of oil-controlling and acne-removing raw materials according to any one of claims 1 to 2, characterized in that: The above composition is used in the preparation of anti-aging and anti-wrinkle skin care products or cosmetics.

7. The use of a composition of oil-controlling and acne-removing raw materials according to any one of claims 1 to 2, characterized in that: The above composition is used in preparing skin care products or cosmetics for skin rejuvenation and brightening.

8. The use of a composition of oil-controlling and acne-removing raw materials according to any one of claims 1 to 2, characterized in that: The above composition is used in preparing skin care products or cosmetics for whitening and lightening spots.

9. The use of a composition of oil-controlling and acne-removing raw materials according to any one of claims 1 to 2, characterized in that: It is characterized by: Application of the above composition in the preparation of skin care products or cosmetics for improving skin barrier.

Images