A traditional Chinese medicine composition for treating viral pneumonia of pathogenic heat obstructing the lungs and its preparation method

Abstract

The present invention belongs to the technical field of traditional Chinese medicine preparations, and specifically relates to a traditional Chinese medicine composition for treating viral pneumonia of the evil-heat obstructing lung type and a preparation method thereof. The traditional Chinese medicine composition comprises the following medicinal materials in parts by weight: 8-12 parts of northern bupleurum, 8-12 parts of scutellaria baicalensis slices, 8-10 parts of French pinellia, 8-12 parts of pseudoginseng, 10-20 parts of forsythia, 10-20 parts of honeysuckle, 3-7 parts of siler, 8-12 parts of astragalus, 11-13 parts of bran-fried atractylodes, 8-12 parts of liquorice slices, 3-7 parts of ginger, 3-7 parts of jujube, 8-12 parts of platycodon, 8-12 parts of schizonepeta, 4-8 parts of cicada slough, 8-10 parts of cyperus rotundus, 20-40 parts of reed rhizome, and 20-40 parts of imperata rhizome. The invention is a pure Chinese medicine preparation, which has the effects of clearing away heat from the interior, invigorating qi and strengthening the body, has a precise therapeutic effect, few side effects, can achieve the effect of treating both the symptoms and the root cause, and the preparation method has the advantages of being suitable for industrial production, and is easy to develop and apply.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for viral pneumonia of the evil-heat obstructing lung type and a preparation method thereof. Background Art

[0002] Viral pneumonia (VP) is an inflammatory disease caused by a virus that affects the trachea, bronchi, bronchioles, alveoli, and interstitial lungs. It typically occurs in winter and spring, and can occur sporadically or in large, densely populated settings. Viruses account for 90% of acute respiratory infections, including adenovirus, respiratory syncytial virus, rhinovirus, influenza virus, and coronavirus. In addition, several highly contagious and highly fatal VP outbreaks have occurred in the past two decades. VP presents clinically with fever, dry cough, fatigue, and even high fever, wheezing, and cyanosis, which can be life-threatening in severe cases. Although VP has not yet established a standardized disease name based on its clinical symptoms, Traditional Chinese Medicine (TCM) defines it as "warm poison," "wind-heat lung heat," "external syndrome," and "asthma syndrome," based on its onset and clinical symptoms. Furthermore, due to its infectious, epidemic, and seasonal nature, it can also be classified as an epidemic or pandemic. It is generally believed that being affected by external pathogens is the direct and main factor in contracting wind-heat diseases, which are mainly characterized by wind-heat and phlegm-heat syndromes.

[0003] Ye Tianshi was the first to propose the concept of "warm pathogens" and, in his Treatise on Warm and Reproductive Diseases, first mentioned that "warm pathogens, when received from above, first attack the lungs." VP is often characterized by "phlegm-heat." This is often caused by exogenous heat pathogens scorching the lung metal, or by wind-cold invading the interior, transforming into heat, which then stagnates and transforms into fire, becoming toxic. The accumulation of pathogenic heat burns the body fluids into phlegm, which accumulates in the lungs, causing lung qi to malfunction and descend, resulting in cough and yellow phlegm. Stagnation of phlegm-heat causes fever, while stagnation of phlegm-heat obstructs lung qi, causing chest tightness and pain. Pang Anshi of the Song Dynasty wrote in Treatise on Febrile Diseases: "When a patient is initially injured by wind and then further injured by heat, the combination of wind and heat causes wind-heat, resulting in paralysis of the limbs, headache, fever, and frequent spontaneous sweating." This clearly outlines the etiology, pathogenesis, and clinical manifestations of wind-heat. Ye Tianshi, a renowned Qing Dynasty expert on warm diseases, proposed in his Treatise on Warm and Reproductive Diseases: "Wind-heat is caused by exposure to wind in spring, when the qi is already warm." He believed that wind-heat is caused by the invasion of warm and heat pathogens in spring. Wu Jutong also pointed out, "Wind-heat syndrome is caused by the initial emergence of Yang Qi in early spring, the Jueyin meridian taking control, and wind mixed with warmth." Traditional Chinese medicine generally understands the etiology of wind-heat lung heat as being caused by the six exogenous pathogenic toxins, which lead to the failure of the lungs to clear and purify, resulting in a disordered Qi mechanism and the accumulation of pathological products such as phlegm, pathogenic heat, and toxic blood stasis in the lungs. Therefore, treatment focuses on clearing heat, penetrating the interior, and replenishing Qi to strengthen the body.

[0004] Currently, modern medicine lacks specific treatment for most viruses. Treatment for VP includes antiviral, immunomodulatory, hormone, symptomatic support, etc., but there are difficulties in treatment such as strong viral variability and lack of specific drugs.

[0005] Therefore, it is of great significance to develop a method for treating VP of the pathogenic heat obstructing lung type by combining traditional Chinese medicine. At the same time, the market also urgently needs a traditional Chinese medicine preparation that is non-toxic, can be fully absorbed by the body, reduces the physical and mental burden of patients, and can effectively treat VP of the pathogenic heat obstructing lung type. Summary of the Invention

[0006] In order to solve the above-mentioned problems existing in the prior art, the present invention provides a traditional Chinese medicine composition for viral pneumonia of the evil-heat obstructing lung type and a preparation method thereof. The present invention is a pure traditional Chinese medicine preparation, which has the effects of clearing away heat from the interior, invigorating qi and strengthening the body, has a definite therapeutic effect, few side effects, and can achieve the effect of treating both the symptoms and the root cause. In addition, the preparation method has the advantages of being suitable for industrial production and is easy to develop and apply.

[0007] In order to achieve the above-mentioned purpose, the technical solution of the present invention is as follows.

[0008] A traditional Chinese medicine composition for viral pneumonia of the evil-heat obstructing lung type comprises the following medicinal materials in parts by weight: 8-12 parts of northern bupleurum, 8-12 parts of scutellaria baicalensis slices, 8-10 parts of French pinellia, 8-12 parts of pseudoginseng, 10-20 parts of forsythia, 10-20 parts of honeysuckle, 3-7 parts of siler, 8-12 parts of astragalus, 11-13 parts of bran-fried atractylodes, 8-12 parts of liquorice slices, 3-7 parts of ginger, 3-7 parts of jujube, 8-12 parts of platycodon, 8-12 parts of schizonepeta, 4-8 parts of cicada slough, 8-10 parts of cyperus rotundus, 20-40 parts of reed rhizome, and 20-40 parts of imperata rhizome.

[0009] Preferably, the traditional Chinese medicine composition for viral pneumonia of evil heat blocking the lungs is prepared by including the following medicinal materials in parts by weight: 10 parts of northern bupleurum, 10 parts of scutellaria tablets, 9 parts of French pinellia, 10 parts of pseudostellaria, 15 parts of forsythia, 15 parts of honeysuckle, 5 parts of siler, 10 parts of astragalus, 12 parts of fried white atractylodes, 10 parts of licorice tablets, 5 parts of ginger, 5 parts of jujube, 10 parts of platycodon, 10 parts of schizonepeta, 6 parts of cicada shells, 9 parts of smilax china, 30 parts of reed rhizome, and 30 parts of imperata rhizome.

[0010] Wherein, the preparation is a Chinese medicine mixture dosage form, that is, an oral preparation.

[0011] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating viral pneumonia of pathogenic heat obstructing the lungs, comprising the following steps:

[0012] Step 1: Pretreatment of medicinal materials;

[0013] Step 2: add 10 times the amount of water of the total medicinal materials and decoct twice, each time for 80 minutes, filter, combine the filtrate, concentrate to 1000 ml, package, and sterilize to obtain a traditional Chinese medicine composition for treating viral pneumonia of evil heat obstructing the lungs.

[0014] Furthermore, the medicinal materials are quality-checked before being put into use, and all the medicinal preparations in the prescription are put into use after being checked to ensure that they comply with the provisions of the first volume of the 2020 edition of the Pharmacopoeia of the People's Republic of China under each medicinal material.

[0015] Northern Bupleurum: This product is the dried root of Bupleurum chinense DC. or Bupleurum corzonerifolium Willd. of the Umbelliferae family.

[0016] The Bupleurum chinense in the prescription meets the requirements under Bupleurum chinense on page 293 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0017] Scutellaria baicalensis tablets: This product is the dried root of Scutellaria baicalensis Georgi, a plant of the Lamiaceae family; it is dug up in spring and autumn, the fibrous roots and mud and sand are removed, and the rough skin is knocked off after being exposed to the sun and dried.

[0018] The Scutellaria baicalensis tablets in the prescription meet the requirements under Scutellaria baicalensis on page 314 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0019] French Pinellia: This product is a processed product of the dried tubers of Pinellia ternata (Thunb.) Breit., a plant of the Araceae family.

[0020] The French Pinellia in the prescription complies with the requirements under the French Pinellia item on page 124 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0021] Pseudostellaria heterophylla: This product is the dried tuberous root of Pseudostellaria heterophylla (Miq.) Pax exPax et Hoffm. of the Caryophyllaceae family.

[0022] The Pseudostellaria baicalensis in the prescription should comply with the requirements under Pseudostellaria baicalensis on page 69 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0023] Forsythia: This product is the dried fruit of Forsythia suspensa (Thunb.) Vahl, a plant of the Oleaceae family.

[0024] The Forsythia suspensa in the prescription should comply with the requirements under Forsythia suspensa on page 177 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0025] Honeysuckle: This product is the dried buds or initially opened flowers of Lonicera japonica Thunb. of the Caprifoliaceae family.

[0026] The honeysuckle in the prescription should comply with the requirements under honeysuckle on page 230 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0027] Saposhnikovia: This product is the dried root of Saposhnikovia divaricata (Turcz.) Schischk. of the Umbelliferae family.

[0028] The Fangfeng in the prescription should comply with the requirements under Fangfeng on page 156 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0029] Astragalus: This product is the dried root of Astragalus membranaceus (Fisch.) Bge.var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. of the legume family.

[0030] The Astragalus in the prescription should comply with the requirements under Astragalus on page 315 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0031] Fried Atractylodes with gluten: This product is a processed product of the dried rhizome of Atractylodes macrocephala Koidz., a plant of the Asteraceae family.

[0032] The stir-fried Atractylodes macrocephala in the prescription should comply with the requirements under Atractylodes macrocephala on page 187 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0033] Licorice tablets: This product is the dried roots and rhizomes of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the legume family.

[0034] The licorice tablets in the prescription should comply with the requirements under licorice on page 88 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0035] Ginger: This product is the fresh rhizome of Zingiber officinale Rose., a plant of the Zingiberaceae family.

[0036] The ginger in the prescription should comply with the requirements under ginger on page 104 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0037] Jujube: This product is the dried mature fruit of Ziziphus jujuba Mill., a plant of the Rhamnaceae family.

[0038] The jujubes in the prescription should comply with the requirements under the jujube item on page 23 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0039] Platycodon: This product is the dried root of Platycodon grandiflorum (Jacq.) A.DC., a plant of the Plantain family.

[0040] The Platycodon grandiflorum in the prescription should comply with the requirements under Platycodon grandiflorum on page 289 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0041] Schizonepeta: This product is the dried above-ground part of Schizonepeta tenuifolia Briq., a plant of the Lamiaceae family.

[0042] The Schizonepeta tenuifolia in the prescription should comply with the requirements under Schizonepeta tenuifolia on page 243 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0043] Cicada molt: This product is the skin shell shed by the nymphs of the black grasshopper Cryptotympana pustulata Fabricius. of the family Acipenser family when they emerge from their shells.

[0044] The cicada shells in the prescription should comply with the requirements of the cicada shells on page 385 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0045] Mianma Guanzhong: This product is the dried rhizome and petiole residues of Dryopteris crassirhizoma Nakai, a plant of the Dryopteris family.

[0046] The Mian Ma Guan Zhong in the prescription complies with the requirements for Mian Ma Guan Zhong on page 344 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0047] Reed rhizome: This product is the fresh or dried rhizome of Phragmites communis Trin., a grass plant.

[0048] The reed root in the prescription should comply with the requirements under reed root on page 171 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0049] Imperata root: This product is the dried rhizome of Imperata cylindrica Beauv.var.major (Nees) CE Hubb., a plant of the Poaceae family.

[0050] The Imperata Root in the prescription should comply with the requirements under Imperata Root on page 111 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0051] The Chinese medicine mixture of the present invention is a Chinese medicine dosage form improved and developed on the basis of traditional decoctions, which retains the advantages of traditional decoctions of fast absorption and rapid effect to the greatest extent, can be mass-produced, avoids the trouble of decocting medicines before use, and is easy to use. In combination with clinical application and the limitations of existing equipment conditions, this prescription is selected to be made into a mixture.

[0052] The effects of the components of a traditional Chinese medicine composition for viral pneumonia caused by pathogenic heat obstructing the lungs are as follows:

[0053] Northern Bupleurum is bitter in taste and slightly cold in nature. It enters the liver and gallbladder meridians. It has the effects of harmonizing the exterior and relieving the interior, soothing the liver, and raising yang. It is the main medicine.

[0054] Scutellaria baicalensis is bitter in taste and cold in nature. It enters the lung, gallbladder, spleen, large intestine and small intestine meridians. It has the effects of clearing heat and dampness, purging fire and detoxifying, stopping bleeding and calming the fetus. It is the minister medicine.

[0055] French Pinellia is pungent in taste and warm in nature. It enters the spleen, stomach and lung meridians. It has the effects of drying dampness and resolving phlegm, relieving adverse reactions and stopping vomiting, and promoting digestion and dispersing stagnation.

[0056] Prince ginseng tastes sweet and slightly bitter, is neutral in nature, and enters the spleen and lung meridians. It has the effects of invigorating qi and strengthening the spleen, promoting fluid production and moistening the lungs.

[0057] Forsythia suspensa tastes bitter and is slightly cold in nature. It enters the lung, heart, and small intestine meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules.

[0058] Honeysuckle tastes sweet and is cold in nature. It enters the lung, heart, and stomach meridians. It has the effects of clearing away heat, detoxifying, and dispersing wind-heat. Honeysuckle and Forsythia are used together to clear away heat, detoxify, and dispersing wind-heat.

[0059] Fangzhi tastes pungent and sweet, and is slightly warm in nature. It enters the bladder, liver, and spleen meridians. It has the effects of dispelling wind and relieving exterior symptoms, eliminating dampness and relieving pain, and stopping spasms.

[0060] Astragalus is sweet in taste and warm in nature. It enters the lung and spleen meridians. It has the effects of replenishing qi and strengthening the exterior, promoting diuresis and detoxification, discharging pus, and healing sores and promoting tissue regeneration.

[0061] Fried Atractylodes macrocephala tastes bitter and dry, is warm in nature, and enters the spleen and stomach meridians. It has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus.

[0062] Licorice is sweet and neutral in nature, and enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain, and harmonizing various herbs. Ginger is pungent and slightly warm in nature, and enters the lung, spleen, and stomach meridians. It has the effects of dispelling cold, warming the middle and stopping vomiting, and resolving phlegm and relieving cough.

[0063] Astragalus nourishes Qi and benefits the exterior, while Atractylodes strengthens the spleen, and the wind-proof function is further enhanced. The defensive Qi is firmly fixed in the exterior, and the body fluids cannot be lost, which has the effect of improving immunity.

[0064] Jujubes are sweet and warm in nature. They enter the spleen, stomach, and heart meridians. They have the effects of tonifying the middle and replenishing qi, nourishing blood and calming the mind.

[0065] Platycodon grandiflorum tastes bitter and spicy, is neutral in nature, and enters the lung meridian. It has the effects of clearing the lungs, relieving sore throat, removing phlegm, and discharging pus.

[0066] Schizonepeta tenuifolia tastes pungent and slightly bitter, and is warm in nature. It enters the lung and liver meridians and has the effects of dispelling wind, clearing rashes, and eliminating sores.

[0067] Cicada slough tastes sweet and salty, is cool in nature, and enters the lung and liver meridians. It has the effects of dispersing wind-heat, clearing rashes and relieving sore throats, removing cataracts and improving eyesight, and dispelling wind and stopping spasms.

[0068] Guanzhong tastes bitter and astringent, is slightly cold in nature, and is slightly toxic. It enters the liver and stomach meridians and has the effects of killing insects, clearing heat, detoxifying, cooling blood and stopping bleeding.

[0069] Reed root is sweet in taste and cold in nature. It enters the lung and stomach meridians. It has the effects of clearing away heat and purging fire, promoting fluid production and quenching thirst, relieving restlessness, stopping vomiting, and promoting diuresis.

[0070] Imperata root is sweet and cold in nature, entering the lung, stomach, and bladder meridians. It has the effects of cooling blood, stopping bleeding, clearing heat, and promoting urination. Imperata root and Phragmites australis root, one clearing and one penetrating, are used together to treat lung-heat-induced coughs and wheezing, clearing lung and stomach heat. Their combined use can clear both qi and blood, induce sweating, relieve exterior symptoms, clear heat and promote urination, and enhance the ability to promote fluid production and quench thirst.

[0071] The combination of these herbs can clear the interior and penetrate the exterior, replenish qi and strengthen the body. It is suitable for people with pathogenic heat entering the interior, raging lung heat, and severe pathogenic heat invading the lungs. Symptoms include high fever, cough, chest and flank fullness and stuffiness, irritability, thirst, spontaneous sweating, dry stool, difficulty urinating, red tongue with yellow fur, and rapid pulse, which are viral pneumonia caused by pathogenic heat blocking the lungs.

[0072] Compared with the prior art, the present invention has the following beneficial effects.

[0073] It can clear the interior and penetrate the exterior, invigorate Qi and strengthen the body, and has a significant and definite effect on the treatment of viral pneumonia of the evil heat blocking the lungs type. It can achieve the effect of treating both the symptoms and the root causes, has few toxic and side effects, simple preparation process, and is suitable for industrial production. It is easy to use and easy to develop and apply, providing patients with a new choice and has good application prospects. DETAILED DESCRIPTION

[0074] The present invention is further described in detail below with reference to specific embodiments.

[0075] A traditional Chinese medicine composition for viral pneumonia of the evil-heat obstructing lung type comprises the following medicinal materials in parts by weight: 8-12 parts of northern bupleurum, 8-12 parts of scutellaria baicalensis slices, 8-10 parts of French pinellia, 8-12 parts of pseudoginseng, 10-20 parts of forsythia, 10-20 parts of honeysuckle, 3-7 parts of siler, 8-12 parts of astragalus, 11-13 parts of bran-fried atractylodes, 8-12 parts of liquorice slices, 3-7 parts of ginger, 3-7 parts of jujube, 8-12 parts of platycodon, 8-12 parts of schizonepeta, 4-8 parts of cicada slough, 8-10 parts of cyperus rotundus, 20-40 parts of reed rhizome, and 20-40 parts of imperata rhizome.

[0076] Furthermore, 10 parts of northern bupleurum, 10 parts of scutellaria slices, 9 parts of French pinellia, 10 parts of pseudoginseng, 15 parts of forsythia, 15 parts of honeysuckle, 5 parts of siler, 10 parts of astragalus, 12 parts of bran-fried atractylodes, 10 parts of liquorice slices, 5 parts of ginger, 5 parts of jujube, 10 parts of platycodon, 10 parts of schizonepeta, 6 parts of cicada shells, 9 parts of mianma cyperus, 30 parts of reed rhizomes, and 30 parts of imperata rhizomes.

[0077] The preparation method of the above-mentioned traditional Chinese medicine composition for treating viral pneumonia of pathogenic heat obstructing the lungs comprises the following steps:

[0078] Step 1: Pretreatment of medicinal materials;

[0079] Step 2: add 10 times the amount of water of the total medicinal materials and decoct twice, each time for 80 minutes, filter, combine the filtrate, concentrate to 1000 ml, package, and sterilize to obtain a traditional Chinese medicine composition for treating viral pneumonia of evil heat obstructing the lungs.

[0080] Example 1.

[0081] A traditional Chinese medicine composition for viral pneumonia of the evil-heat obstructing lung type is prepared from the following medicinal materials: 10 parts of northern bupleurum, 10 parts of scutellaria baicalensis slices, 9 parts of French pinellia, 10 parts of pseudostellaria, 15 parts of forsythia, 15 parts of honeysuckle, 5 parts of siler, 10 parts of astragalus, 12 parts of bran-fried white atractylodes, 10 parts of liquorice slices, 5 parts of ginger, 5 parts of jujube, 10 parts of platycodon, 10 parts of schizonepeta, 6 parts of cicada slough, 9 parts of cyperus rotundus, 30 parts of reed rhizome, and 30 parts of imperata rhizome.

[0082] The preparation method thereof comprises the following steps:

[0083] Step 1: Pretreatment of medicinal materials:

[0084] The quality of the medicinal slices of Chaiqin Qingre Mixture is checked before use. All the medicinal slices in the prescription are checked to be in compliance with the provisions of the Pharmacopoeia of the People's Republic of China (2020 edition) under each medicinal material item before use.

[0085] Bupleurum chinense DC. or Bupleurum corzonerifolium Willd., both of the Apiaceae family, are dried roots.

[0086] The Bupleurum chinense in the prescription complies with the requirements under Bupleurum chinense on page 293 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China. Huangqin tablets: This product is the dried root of Scutellaria baicalensis Georgi, a plant of the Lamiaceae family. It is harvested in spring and autumn, the fibrous roots and mud and sand are removed, the skin is peeled off after sun-drying, and the Huangqin tablets in the prescription comply with the requirements under Huangqin on page 314 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0087] French Pinellia: This product is a processed product of the dried tuber of Pinellia ternata (Thunb.) Breit., a plant of the Araceae family; the French Pinellia in the prescription complies with the requirements of the French Pinellia on page 124 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China; Pseudostellaria heterophylla: This product is a dried root tuber of Pseudostellaria heterophylla (Miq.) Paxex Pax et Hoffm., a plant of the Caryophyllaceae family; the Pseudostellaria heterophylla in the prescription should comply with the requirements of the Pseudostellaria heterophylla on page 69 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China;

[0088] Forsythia suspensa: This product is the dried fruit of Forsythia suspensa (Thunb.) Vahl, a plant of the Oleaceae family. The Forsythia suspensa in the prescription should comply with the requirements of the Forsythia suspensa section on page 177 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0089] Honeysuckle: This product is the dried buds or early blooming flowers of Lonicera japonica Thunb. of the Caprifoliaceae family. The honeysuckle in the prescription should comply with the requirements of the "Pharmacopoeia of the People's Republic of China" Volume 1, page 230, under the honeysuckle.

[0090] Saposhnikovia divaricata (Turcz.) Schischk., a plant of the Umbelliferae family, is a dried root of Saposhnikovia divaricata (Turcz.). The Saposhnikovia in the prescription should comply with the requirements of Saposhnikovia divaricata on page 156 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0091] Astragalus: This product is the dried root of Astragalus membranaceus (Fisch.) Bge.var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. of the Leguminosae family. The Astragalus in the prescription should comply with the requirements under Astragalus on page 315 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0092] Stir-fried Atractylodes macrocephala with bran: This product is a processed product of the dried rhizome of Atractylodes macrocephala Koidz. of the Asteraceae family. The stir-fried Atractylodes macrocephala in the prescription should comply with the requirements under Atractylodes macrocephala on page 187 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0093] Licorice tablets: This product is the dried roots and rhizomes of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat., or Glycyrrhiza glabra L., all of the legume family. Licorice tablets in prescriptions should comply with the requirements for licorice on page 88 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0094] Ginger: This product is the fresh rhizome of Zingiber officinale Rose. (Zingiber officinale Rose). The ginger in the prescription should comply with the requirements for ginger on page 104 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0095] Jujube: This product is the dried mature fruit of Ziziphus jujuba Mill., a plant of the Rhamnaceae family. The jujube in the prescription should comply with the requirements under jujube on page 23 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0096] Platycodon grandiflorum: This product is the dried root of Platycodon grandiflorum (Jacq.) A.DC. of the family Plantain family. The Platycodon grandiflorum in the prescription should comply with the requirements of the Platycodon grandiflorum in the Pharmacopoeia of the People's Republic of China, Volume 1, page 289, 2020 edition.

[0097] Schizonepeta: This product is the dried aerial part of Schizonepeta tenuifolia Briq., a plant of the Lamiaceae family. The Schizonepeta in the prescription should comply with the requirements of Schizonepeta on page 243 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0098] Cicada slough: This product is the skin shed by the nymphs of the black grasshopper Cryptotympana pustulata Fabricius. of the family Aphididae when they emerge from their shells. The cicada slough in the prescription should comply with the requirements of the "Pharmacopoeia of the People's Republic of China" Volume 1, page 385, 2020 edition.

[0099] Mianma Guanzhong: This product is the dried rhizome and petiole residues of Dryopteris crassirhizoma Nakai, a plant of the Dryopteris family. The Mianma Guanzhong in the prescription meets the requirements for Mianma Guanzhong on page 344 of Volume 1 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0100] Phragmites rhizome: This product is the fresh or dried rhizome of Phragmites communis Trin. (Grape family); the Phragmites rhizome in the prescription should comply with the requirements for Phragmites rhizome in the Pharmacopoeia of the People's Republic of China, Volume 1, page 171, 2020 edition.

[0101] Imperata cylindrica root: This product is the dried rhizome of Imperata cylindrica Beauv. var. major (Nees) CE Hubb., a grass family plant. The Imperata cylindrica root in the prescription should comply with the requirements of Imperata cylindrica root on page 111 of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

[0102] Step 2: add 10 times the amount of the total medicinal materials into water and boil twice, each time for 80 minutes, filter, combine the filtrates, concentrate, package and sterilize to obtain the product.

[0103] Example 2.

[0104] 1. Sample

[0105] The Chinese medicine composition for viral pneumonia of pathogenic heat obstructing the lungs prepared in Example 1 is 500 ml per bottle, 50 ml each time, three times a day.

[0106] 2. Subjects

[0107] 2.1 Diagnostic criteria

[0108] Western medicine diagnosis refers to the diagnostic criteria for viral pneumonia in Internal Medicine (7th Edition) (edited by Lu Zaiying and Zhong Nanshan, People's Medical Publishing House, 2008).

[0109] (1) It is more common during the season when viral diseases are prevalent.

[0110] (2) The onset is acute, with prominent symptoms such as fever, headache, body aches, and fatigue. Before the acute influenza symptoms subside, coughing occurs, which is mostly dry cough with little sputum or white mucus sputum, sore throat and other respiratory symptoms.

[0111] (3) There may be no obvious chest signs, or dry or wet rales may be heard.

[0112] (4) The white blood cell count is normal, slightly high or low, the erythrocyte sedimentation rate is normal, the white blood cells seen in the sputum smear are mostly monocytes, and no pathogenic bacteria grow in the sputum culture.

[0113] (5) Chest X-ray examination shows increased lung markings, small patchy infiltration or extensive infiltration,

[0114] (6) Nasal swab, throat swab virus antigen positive or virus isolation test positive or specific antibody test positive or serum virus antibody titer increased by 4 times or more. The TCM diagnostic standards refer to the "National Standard Application - TCM Internal Medicine Disease Diagnosis and Treatment Routine"

[0115] Pathogenic Heat Obstructing the Lung Syndrome: Primary symptoms include persistent high fever, cough, rusty or thick yellow sputum, chest pain, and shortness of breath. Secondary symptoms include thirst and irritability, dry stool, and dark yellow urine. Tongue and pulse include a red tongue with a yellow coating and a slippery or rapid pulse. Patients must present with two primary symptoms plus two secondary symptoms, or one primary symptom plus three secondary symptoms. This syndrome is diagnosed based on the tongue and pulse.

[0116] 2.2 Inclusion criteria

[0117] (1) Meet the above diagnostic criteria;

[0118] (2) Aged 18 to 80 years old, regardless of gender;

[0119] (3) The patients understood and voluntarily participated in this study and signed the informed consent form.

[0120] 2.3 Exclusion criteria

[0121] (1) Combined with malignant tumors, blood diseases, and severe immune system diseases;

[0122] (2) combined with severe liver and kidney dysfunction;

[0123] (3) Those who are allergic to the ingredients of this study drug;

[0124] (4) Severe mental illness or inability to cooperate with the trial;

[0125] (5) Pregnant or lactating women

[0126] 2.4 Rejection criteria

[0127] (1) Subjects who did not take the medication at the prescribed time and dosage;

[0128] (2) Incomplete data or serious complications that affect the judgment of efficacy or safety;

[0129] (3) The subject is unable to cooperate or actively requests to terminate the trial.

[0130] 3. Experimental Design and Grouping

[0131] 3.1 Trial Grouping

[0132] Thirty subjects were included in the self-controlled before-after study.

[0133] 3.2 Treatment methods

[0134] The medicinal composition for viral pneumonia of the evil-heat obstructing lung type is used for treatment, 50 ml each time, once in the morning, noon and evening every day, and the treatment time is 10 days.

[0135] 3.3 Observation indicators

[0136] (1) Record the TCM symptom scores of the subjects' pathogenic heat obstructing the lungs before and 10 days after treatment;

[0137] (2) Efficacy evaluation: Calculate the symptom score reduction using the following formula: (pre-treatment score - post-treatment score) / pre-treatment score × 100%. A larger value indicates a better efficacy. ≥70% is considered markedly effective, >30% to 70% is considered effective, and ≤30% is considered ineffective. The total markedly effective rate = number of markedly effective cases / total number of cases × 100%.

[0138] 3.4 Data processing and result determination

[0139] Data were processed and analyzed using SPSS 25.0 statistical software. Enumeration data were expressed as rate or composition ratio (%), and the chi-square test was used. 2 Measurement data were expressed as mean ± standard deviation (`x±s) and compared using independent sample t-test. P < 0.05 was considered statistically significant.

[0140] 4 Results

[0141] 4.1 Analysis of general data of subjects

[0142] There were no dropouts or withdrawals during the observation period. The general information of the subjects before treatment is shown in Table 1.

[0143] Table 1 Comparison of gender distribution of subjects in the two groups.

[0144] category Number of cases Gender (male / female) Age (years) General Information 30 14 / 16 59.13±12.06

[0145] 4.2 Main TCM symptom scores before and after treatment

[0146] Table 2 Comparison of main TCM symptom scores before and after treatment.

[0147]

[0148] As shown in Table 2, the TCM symptom scores and TCM syndrome scores for persistent high fever, cough, rusty or thick yellow sputum, chest pain, and shortness of breath after treatment were compared with those before treatment using an independent sample t-test, and the differences were statistically significant (P < 0.05). This indicates that the TCM herbal medicine of the present invention has a significant effect on improving TCM symptoms in patients with phlegm-heat congestion in the lungs type of viral pneumonia.

[0149] 4.3 Minor TCM symptom scores before and after treatment

[0150] Table 3 Comparison of minor TCM symptom scores before and after treatment.

[0151] symptom Pre-treatment score Post-treatment score t-value P-value Thirst and irritability 8.27±1.26 0.86±1.01 4.75 0.000 dry stools 1.53±1.35 0.53±1.04 3.20 0.002 Yellow or dark urine 1.73±1.14 0.73±0.98 3.63 0.001

[0152] As shown in Table 3, the TCM symptom scores and TCM syndrome scores for thirst and irritability, dry stool, and dark urine after treatment were compared with those before treatment using an independent sample t-test, and the differences were statistically significant (P < 0.05). This indicates that the TCM symptom-improving effect of the present invention is significant for patients with phlegm-heat congestion in the lung type of viral pneumonia.

[0153] 4.4 Comparison of efficacy assessment

[0154] Table 4 Comparison of efficacy judgment between the two groups of subjects.

[0155] type Significant effect efficient invalid Efficiency Efficacy assessment 17(56.67％) 12(40.00％) 1(3.33％) 96.67％

[0156] As shown in Table 4, 17 cases showed marked effect, 12 cases showed effective effect, and the effective rate was 96.67% (29 / 30), indicating that the Chinese medicine of the present invention has a significant effect on improving the symptoms of patients with phlegm-heat congestion in the lungs.

[0157] Example 3.

[0158] Case 1.

[0159] Mr. Li, male, 33 years old, employee, came to the clinic on April 8, 2024.

[0160] Symptoms: Suffering from viral pneumonia of evil heat blocking the lungs, the main symptoms are high fever, cough, a small amount of yellow sputum, fullness and stuffiness in the chest and flanks, irritability, thirst, spontaneous sweating, etc.

[0161] Application: Use the Chinese medicine composition of Example 1; take 50 ml each time, morning, noon and evening, for 10 days as a course of treatment.

[0162] Efficacy: After 10 days of administration of the drug, the patient's symptoms of persistent high fever, cough, yellow sputum, chest and flank fullness, irritability, thirst, spontaneous sweating, etc. were basically eliminated.

[0163] Case 2.

[0164] Sun, female, 54 years old, worker, came to the clinic on January 1, 2023.

[0165] Symptoms: Suffering from viral pneumonia of evil heat blocking the lungs, the main symptoms are high fever, cough, a small amount of yellow sputum, fullness and stuffiness in the chest and flanks, irritability, thirst, spontaneous sweating, etc.

[0166] Application: Use the Chinese medicine composition of Example 1; take 50 ml each time, morning, noon and evening, for 10 days as a course of treatment.

[0167] Efficacy: After 10 days of administration of the present invention, the patient's symptoms of persistent high fever, cough, yellow sputum, chest and flank fullness, irritability, thirst, spontaneous sweating, etc. were almost cured.

[0168] The above description is merely a preferred embodiment of the present application and is not intended to limit the present application. Various modifications and variations are possible for those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present application shall be included within the scope of protection of the present application.

Claims

1. A Chinese medicine composition for treating viral pneumonia of pathogenic heat obstructing the lungs, characterized in that: The invention is composed of the following medicinal materials in parts by weight: 8-12 parts of northern bupleurum, 8-12 parts of scutellaria slices, 8-10 parts of French pinellia, 8-12 parts of pseudoginseng, 10-20 parts of forsythia, 10-20 parts of honeysuckle, 3-7 parts of siler, 8-12 parts of astragalus, 11-13 parts of bran-fried atractylodes, 8-12 parts of liquorice slices, 3-7 parts of ginger, 3-7 parts of jujube, 8-12 parts of platycodon, 8-12 parts of schizonepeta, 4-8 parts of cicada slough, 8-10 parts of cyperus rotundus, 20-40 parts of reed rhizome, and 20-40 parts of imperata rhizome.

2. A Chinese medicine composition for treating viral pneumonia of pathogenic heat obstructing the lungs, characterized in that: The invention is composed of the following medicinal materials in parts by weight: 10 parts of northern bupleurum, 10 parts of scutellaria slices, 9 parts of French pinellia, 10 parts of pseudoginseng, 15 parts of forsythia, 15 parts of honeysuckle, 5 parts of siler, 10 parts of astragalus, 12 parts of stir-fried white atractylodes, 10 parts of liquorice slices, 5 parts of ginger, 5 parts of jujube, 10 parts of platycodon, 10 parts of schizonepeta, 6 parts of cicada slough, 9 parts of cyperus rotundus, 30 parts of reed rhizome and 30 parts of imperata rhizome.

3. A method for preparing a Chinese medicine composition for treating viral pneumonia of pathogenic heat obstructing the lungs according to any one of claims 1 to 2, characterized in that: The steps include: Step 1: Pretreatment of medicinal materials; Step 2: add 10 times the amount of water of the total medicinal materials and decoct twice, each time for 80 minutes, filter, combine the filtrate, concentrate to 1000 ml, package, and sterilize to obtain a traditional Chinese medicine composition for treating viral pneumonia of evil heat obstructing the lungs.

4. The preparation method according to claim 3, characterized in that In the step 1, the medicinal materials are quality checked before being put into use, and all the medicinal pieces in the prescription are put into use after being checked to be in compliance with the provisions of each medicinal material under Part I of the 2020 edition of the Pharmacopoeia of the People's Republic of China.

5. The preparation method according to claim 3, characterized in that The Chinese medicine composition is a Chinese medicine mixture.

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