Tetrapeptides with improved cognitive function and uses thereof

By developing a Lys-Gly-Phe-Pro tetrapeptide that binds to GABABR, the cAMP/PKA/CREB signaling pathway is activated, addressing cognitive impairment caused by neurodegenerative diseases and achieving the effect of improving the vitality and cognitive function of senescent cells.

CN118702769BActive Publication Date: 2026-06-09HANGZHOU KANGYUAN FOOD SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU KANGYUAN FOOD SCI & TECH
Filing Date
2024-08-29
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing technologies have failed to effectively address cognitive impairment caused by neurodegenerative diseases, particularly by inhibiting GABABR to promote GABA release and activating the cAMP/PKA/CREB signaling pathway to improve age-induced cognitive impairment.

Method used

A tetrapeptide with the amino acid sequence Lys-Gly-Phe-Pro was developed to improve cognitive function. By binding to GABABR, it regulates the specific interactions of amino acid residues on the nerve cell membrane, activates the cAMP/PKA/CREB signaling pathway, promotes the release of the inhibitory neurotransmitter GABA, and increases the expression of antioxidant enzymes and neurotrophic factors.

Benefits of technology

It significantly enhances the vitality of senescent cells and improves cognitive function by inhibiting GABABR expression, activating the cAMP/PKA/CREB signaling pathway, promoting GABA release, increasing antioxidant enzyme activity, protecting nerve cells, and improving age-induced cognitive impairment.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to the field of bioactive peptide technology, and discloses a tetrapeptide with cognitive-improving function and its applications. The primary amino acid sequence of the tetrapeptide is Lys-Gly-Phe-Pro, and its molecular weight is 489.2587 Da. The tetrapeptide of this invention can be chemically synthesized or directionally prepared from sea cucumber protease hydrolysates. The tetrapeptide of this invention exhibits cognitive-improving activity, mainly through inhibiting GABA. B The expression of R activates the cAMP / PKA / CREB signaling pathway, promotes the release of the inhibitory neurotransmitter GABA, reduces oxidative stress damage, increases the gene expression of neurotrophic factors Bdnf and Nt3, and significantly upregulates the gene expression of antioxidant enzymes Sod1 and Gpx1, thereby exerting a neuroprotective effect and improving age-induced cognitive impairment.
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