A traditional Chinese medicine composition for preventing and treating gouty arthritis and application thereof
The treatment of gouty arthritis using a combination of traditional Chinese medicine ingredients, including honeysuckle, chicory, daylily, and eucommia leaves, addresses the issues of weakened efficacy and severe side effects associated with long-term use of Western medicine. This approach effectively lowers uric acid levels, reduces inflammation, and improves arthritis symptoms and kidney damage.
Patent Information
- Application Number
- CN202411023239.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-29
- Publication Date
- 2026-01-20
- Estimated Expiration
- 2044-07-29
AI Technical Summary
Current Western medicine treatments for gouty arthritis suffer from reduced efficacy and significant side effects after long-term use. There is a need for a long-term effective treatment with fewer side effects.
A traditional Chinese medicine composition using honeysuckle, chicory, daylily, and eucommia leaves as the main ingredients is prepared into an oral or injectable formulation based on the traditional Chinese medicine theory of "clearing heat and dampness, unblocking the meridians and relieving pain" for the treatment of gouty arthritis.
It significantly reduces blood uric acid levels in patients with gouty arthritis, improves joint swelling and inflammation, reduces kidney damage, improves quality of life, and has no obvious toxic side effects.
Smart Images
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for preventing and treating gouty arthritis and application thereof. BACKGROUND
[0002] Gout is a disease caused by the disorder of uric acid metabolism in the body, which is divided into primary and secondary. Primary gout is mainly related to genetic defects, and is usually inherited in families. The main symptoms of primary gout include joint pain, swelling and inflammation. If not treated in time, gouty tophi will gradually form, which can affect joint function and even cause disability. Secondary gout is a kind of gout caused by other diseases or conditions, which often appears with other diseases, such as kidney disease, hypertension, diabetes, etc. The symptoms of secondary gout are various, which may include joint pain, swelling, fever, fatigue, etc. These symptoms may be similar to those of other diseases, so they are often misdiagnosed. The prominent features of primary and secondary gout are hyperuricemia and deposition of sodium urate crystals in connective tissue structures (especially cartilage and synovial membrane).
[0003] Gouty arthritis (GA) is a disease caused by deposition of urate crystals in the joint cavity, which causes acute inflammatory reaction. According to the site of onset, gouty arthritis can be divided into foot gouty arthritis, hand gouty arthritis, etc. The damaged site of gouty arthritis is red, swollen, hot and painful. Once the joint capsule, bursa and cartilage of the ankle joint and its foot joints are severely damaged, deformity of the damaged site will occur. And with the change of dietary structure, the incidence of gouty arthritis is increasing year by year, which seriously affects the daily life of patients.
[0004] At present, the principles of western medicine in treating gouty arthritis are as follows: (1) Inhibition of uric acid production: some western medicines such as allopurinol and febuxostat can inhibit the production of uric acid by inhibiting the activity of xanthine oxidase and reducing the production of uric acid; (2) Promoting uric acid excretion: some western medicines such as probenecid and benzbromarone can increase the excretion of uric acid by increasing the glomerular filtration rate and the excretion of uric acid in urine, thereby reducing the blood uric acid level; (3) Anti-inflammatory analgesic: some non-steroidal anti-inflammatory drugs and colchicine can relieve inflammation and pain caused by gout by inhibiting the metabolic pathway of arachidonic acid and reducing the production of prostaglandin E2; (4) Immune regulation: some immunosuppressants such as glucocorticoids can regulate immune response and reduce inflammation of joints caused by gout. Western medicine plays an effective role in treating gouty arthritis to a certain extent, but with the prolongation of medication course, the drug efficacy decreases, drug safety and adverse reactions of the drug to the body gradually attract people's attention. For example, long-term use of uric acid-lowering drugs or anti-inflammatory drugs may cause liver and kidney damage, allergic reactions and other health problems.
[0005] Gouty arthritis patients need long-term treatment, so it is necessary to find a long-term effective and less toxic side effects of therapy. The invention group has long been committed to the treatment of gouty arthritis in TCM research, for the present stage gouty arthritis patients in need of long-term anti-gouty arthritis drug, the status quo, accidentally obtained a kind of Chinese medicine composition for preventing and treating gouty arthritis. SUMMARY
[0006] The primary object of the present application is to provide a kind of Chinese medicine composition for preventing and treating gouty arthritis, the Chinese medicine composition includes the following raw medicine: honeysuckle, chrysanthemum, day lily, papaya, eucommia leaf.
[0007] Preferably, the Chinese medicine composition includes the following weight parts of raw medicine: honeysuckle 24 parts, chrysanthemum 24 parts, day lily 24 parts, papaya 12 parts, eucommia leaf 24 parts
[0008] Preferably, the Chinese medicine composition is composed of the following weight parts of raw medicine: honeysuckle 24 parts, chrysanthemum 24 parts, day lily 24 parts, papaya 12 parts, eucommia leaf 24 parts.
[0009] Preferably, add pharmaceutically acceptable adjuvant, preparation into oral preparation or injection preparation.
[0010] Preferably, the oral preparation includes tablet, capsule, granule, pill, syrup, oral solution, oral suspension or oral emulsion.
[0011] Preferably, the injection preparation includes injection or powder injection.
[0012] The second object of the present application is to provide a kind of medicine, including the Chinese medicine composition.
[0013] The third object of the present application is to provide the application of the Chinese medicine composition in preparing for preventing and treating gouty arthritis.
[0014] The important composition is guided by the TCM theory of "clearing heat and dampness, dredging collaterals and relieving pain", the honeysuckle has the effects of dispelling evil, dispelling wind and dampness, clearing heat and relieving pain, and the chrysanthemum can clear liver and gallbladder, invigorate the stomach and resolve food, and the two are the monarch drugs and can clear heat and dampness; the day lily has the effects of relieving depression, damp heat, diuresis, stopping bleeding and cooling blood, and can enhance the effect of clearing heat and dampness of the monarch drug, and is the minister drug; the chaenomeles can relax the meridians and the eucommia leaf has the effects of relieving inflammation and pain, and the two can enhance the effect of clearing heat and dampness of the monarch and minister drugs, and can also relax the meridians, and are the assistant drugs. The whole prescription is based on the pathogenesis and clinical characteristics of "damp heat accumulation and meridian obstruction", and can clear heat and dampness, dredge collaterals and relieve pain. The monarch and minister drugs in the traditional Chinese medicine composition of Jingu Qubi granules are appropriate, the ratio is reasonable, the blood uric acid level of the rats can be significantly improved, the serum inflammatory factors are significantly reduced, and the joint swelling degree and gait score are obviously improved. The traditional Chinese medicine composition is applied to the clinical patients, and the TCM clinical symptoms of the patients are significantly improved, and the life quality scores are significantly higher than those before treatment.
[0015] The application has the beneficial effects that the application provides a traditional Chinese medicine composition for preventing and treating gouty arthritis, the traditional Chinese medicine composition comprises the following raw medicinal materials: honeysuckle, chrysanthemum, day lily, chaenomeles and eucommia leaf, the traditional Chinese medicine composition can significantly reduce the serum uric acid, IL-1β, IL-6 and TNF-α indexes of rats, can reduce the uric acid level of gouty arthritis patients, has the anti-inflammatory effect and analgesic effect, can treat gouty arthritis, can effectively improve the kidney damage of gouty arthritis rats, has no toxic side effects, and has a wide application prospect. DETAILED DESCRIPTION
[0016] The technical solutions of the application will be described clearly and completely in combination with the embodiments. Obviously, the described embodiments are part of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the application. Embodiment one, traditional Chinese medicine composition for treating gouty arthritis
[0017] 1 Experimental process
[0018] 1.1 Establishment of the gouty arthritis model of rats and grouping
[0019] 110 8-week-old SD male rats weighing 300 ± 20 g were purchased from the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences and were raised in the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences. After 1 week of adaptive feeding, a hyperuricemia model was established by intragastrically administering adenine (100 mg / kg) and ethambutol hydrochloride (250 mg / kg) for 21 days. One hour after the last intragastric administration, the rats in each group were anesthetized, a 6-gauge needle was inserted into the right ankle joint cavity at an angle of 45° between the tibia and the upper front side of the needle opening, and 0.2 mL of 0.5 g / mL MSU solution was injected into each group except the normal group, which was injected with the same volume of normal saline. An acute gouty arthritis model was replicated in rats. Except for the blank control group, the rats were randomly divided into a model group, a low-dose traditional Chinese medicine group, a medium-dose traditional Chinese medicine group, a high-dose traditional Chinese medicine group, a positive drug control group of Tongfengsh tablets, a positive drug control group of febuxostat, a positive drug control group of colchicine, a patent 1 group, a patent 2 group, and a patent 3 group, with 10 rats in each group. The dosages of Jinquzhbi granules were converted according to the body surface area coefficient of humans and rats in the Pharmacological Research Methodology of Traditional Chinese Medicine. The model group was administered with adenine 100 mg / kg and ethambutol hydrochloride 250 mg / kg, the low-dose group was administered with 0.6075 g / kg, the medium-dose group was administered with 1.215 g / kg, the high-dose group was administered with 2.43 g / kg, the positive drug control group of Tongfengsh tablets was administered with 324 mg / kg, the positive drug control group of febuxostat was administered with 7.2 mg / kg, the positive drug control group of colchicine was administered with 0.27 mg / kg, the blank control group was administered with the same volume of distilled water, the patent 1 group was administered with honeysuckle 2 parts, chicory 2 parts, and papaya 1 part at a dosage of 0.675 g / kg, the patent 2 group was administered with eucommia leaf 2 parts at a dosage of 0.27 g / kg, and the patent 3 group was administered with day lily 2 parts at a dosage of 0.27 g / kg. Each group of rats was intragastrically administered for 2 weeks.
[0020] 1.2 Observation indicators and measurement methods
[0021] (1) General observation of rats: The hair, diet, water intake, and excretion of rats in each group were observed and recorded every day, and the body weight of rats was recorded every week during the experiment.
[0022] (2) Observation of joint swelling in rats: Before modeling with sodium urate (on day 21), the swelling degree of the rat's foot was measured using the circumference method, and the circumference of the rat's right hind foot ankle joint at 0.5 cm was measured using a tape measure (with a minimum scale of 0.5 mm). Three experimenters each measured once and recorded, and the average value was taken as the final result. The joint swelling degree was calculated using the formula: right hind foot joint swelling degree at different times after modeling = circumference value at different times after modeling - circumference value before modeling.
[0023] (3) Body weight and organ index analysis: After the end of drug intervention, the body weight of the rats was weighed, the liver and kidney of the rats were taken out, the connective tissue around the clean organs was removed, and the weight was immediately weighed. The organ index (%) was calculated according to the following formula: organ index (%) = organ weight (mg) / body weight (g) x 100%.
[0024] (4) Hematology index detection: After the end of drug intervention, blood was taken after sodium pentobarbital injection anesthesia, and after blood collection, the supernatant was collected after low-speed centrifugation at 3000 rpm for 10 min, and the blood uric acid value was determined on the animal automatic biochemical analyzer. The contents of inflammatory factors IL-1β, IL-6 and TNF-α in the serum of rats were detected by ELISA method.
[0025] 2. Experimental results
[0026] 2.1 General observation of rats
[0027] As shown in Table 1, the body weight of rats in each group had no statistical difference before modeling.
[0028] Table 1 Body weight of rats in different groups
[0029]
[0030] 2.2 Observation of joint swelling degree of rats
[0031] As shown in Table 2, compared with the blank group, the ankle joint of the rats in the model group showed obvious joint swelling, and the difference was statistically significant (P<0.01), which indicated that the modeling was successful.
[0032] Table 2 Change of joint swelling degree of rats in different groups
[0033]
[0034] 2.3 Liver and kidney index of rats
[0035] As shown in Table 3, the liver organ coefficient of rats in each group had no obvious change, and the difference was not statistically significant (P>0.05); as shown in Table 4, compared with the blank group, the kidney organ coefficient of rats in the model group was significantly increased, and the kidney organ index coefficient of rats in the remaining groups was significantly reduced, among which the non-busilast group and the medium dose group of Jinju Qubi Granules had the best effect, and the difference was statistically significant (P<0.01). It was indicated that the traditional Chinese medicine composition for preventing and treating gouty arthritis in the application could effectively improve the kidney damage of rats with gouty arthritis.
[0036] Table 3 Liver index of rats in different groups
[0037]
[0038] Table 4 Kidney index of rats in different groups
[0039]
[0040] 2.4 Rat Hematology Index
[0041] As shown in Tables 5-8, compared with the blank group, the serum uric acid, IL-1β, IL-6, TNF-α indexes of the model group rats were significantly increased, and compared with the model group, the indexes of each drug group were significantly decreased, among which, in serum uric acid, the effects of the non-busilast group and the Chinese medicine medium dose group were most obvious (P<0.01), and in IL-1β, IL-6, TNF-α, the effects of the colchicine group and the Chinese medicine medium dose group were most obvious (P<0.01). It is proved that the Chinese medicine composition for preventing and treating gouty arthritis of the application can effectively improve the blood uric acid level and inflammatory indexes of rats with gouty arthritis.
[0042] Table 5 Change of serum uric acid of rats in different groups
[0043]
[0044] Table 6 Change of serum IL-1β of rats in different groups
[0045]
[0046] Table 7 Change of serum IL-6 of rats in different groups
[0047]
[0048] Table 8 Change of serum TNF-α of rats in different groups
[0049]
[0050] In summary, the application provides a Chinese medicine composition for preventing and treating gouty arthritis, which comprises the following raw medicinal materials: honeysuckle, chicory, day lily, papaya, eucommia leaf, the Chinese medicine composition for treating gouty arthritis, the serum uric acid, IL-1β, IL-6, TNF-α indexes of rats are significantly decreased, which proves that the Chinese medicine composition can reduce the uric acid level of patients with gouty arthritis and play its anti-inflammatory effect and analgesic effect, so as to treat gouty arthritis, and can effectively improve the kidney damage of rats with gouty arthritis, has no toxic side effects, and has a broad application prospect.
Claims
1. A traditional Chinese medicine composition for the prevention and treatment of gouty arthritis, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: honeysuckle 24 parts, chicory 24 parts, daylily 24 parts, papaya 12 parts, and eucommia leaf 24 parts.
2. The traditional Chinese medicine composition as described in claim 1, characterized in that, Pharmaceutically acceptable excipients are added to prepare oral or injectable formulations.
3. The traditional Chinese medicine composition as described in claim 2, characterized in that, The oral preparations include tablets, capsules, granules, pills, syrups, oral solutions, oral suspensions, or oral emulsions.
4. The traditional Chinese medicine composition as described in claim 2, characterized in that, The injectable formulation includes an injection solution or a powder for injection.
5. A drug for the prevention and treatment of gouty arthritis, characterized in that, It is prepared from the traditional Chinese medicine composition according to claim 1.
6. The use of the traditional Chinese medicine composition as described in claim 1 in the preparation of a drug for the prevention and treatment of gouty arthritis.