A traditional Chinese medicine preparation for treating hyperlipidemia

Abstract

The application discloses a kind of traditional Chinese medicine preparation for treating hyperlipidemia, which is prepared from the following raw medicinal materials: radix codonopsis 10-20 g, astragalus 25-35 g, gynostemma pentaphyllum 10-20 g, atractylodes 10-20 g, zanthoxylum 3-8 g, monascus 10-15 g, and galangal 10-20 g. When treating, it is orally taken, one dose per day, taken twice, taken half an hour after breakfast and dinner, and continuously taken for 4 weeks as a treatment course. The traditional Chinese medicine preparation for treating hyperlipidemia has the advantages that it is helpful to improve hyperlipidemia, and the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and other indicators of patients after treatment are obviously better than those of the control group (oral atorvastatin), with statistical significance (P<0.05). The traditional Chinese medicine preparation for treating hyperlipidemia has the advantages of remarkable curative effect, good safety, low price and simple prescription, and has high clinical popularization value.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of traditional Chinese medicine preparation for treating hyperlipidemia, belong to traditional Chinese medicine preparation technical field. BACKGROUND

[0002] Hyperlipidemia is also called lipid metabolism disorder or abnormality, which is a metabolic disease caused by various reasons, and is characterized by the increase of one or more lipid levels in plasma, such as total cholesterol, triglyceride and low-density lipoprotein cholesterol, or the decrease of high-density lipoprotein cholesterol. It is recognized as an independent risk factor for the onset of various internal diseases. With the improvement of people's living standards and the change of eating habits, the prevalence of hyperlipidemia is increasing. Hyperlipidemia in China is becoming younger and younger. How to better prevent and treat hyperlipidemia is crucial to reduce the incidence of cardiovascular and cerebrovascular events. At present, the most widely used drugs for treating hyperlipidemia in modern medicine are statins, fibrates and niacin drugs. Although the efficacy is positive, adverse reactions such as liver damage and gastrointestinal reactions are often reported.

[0003] Traditional Chinese medicine is profound and has great advantages in the treatment of hyperlipidemia. There is no disease name of hyperlipidemia in traditional Chinese medicine, which can be classified into "phlegm", "obesity", "blood stasis", "dampness" and "dizziness" in traditional Chinese medicine. The main organs involved in the pathogenesis are spleen, kidney and liver, and the main pathological mechanism is "deficiency in root and excess in branch". The deficiency of qi, blood, yin and yang is the root, and the phlegm and blood stasis are the branch. The pathological state of hyperlipidemia is summarized as "cream", "fat" and "turbidity". It belongs to the category of fat cream in blood, and the thick one is fat and the thin one is cream. "Ganfei Guiren is a disease of cream and grain. Isolation, blockage and closure, and the obstruction of upper and lower channels, are the diseases of worry". "Ling Shu · Five Leukorrhea and Body Fluids Differentiation Third Thirty-six" has "the body fluid of five cereals, and the cream is mixed and infiltrated into the bone space, supplements the brain marrow, and flows down to the femoral shadow". Therefore, further research is needed to find the exact traditional Chinese medicine compound preparation to meet the needs of domestic and foreign markets. SUMMARY

[0004] In view of the above prior art, the present application provides a traditional Chinese medicine preparation for treating hyperlipidemia.

[0005] The present application is realized by the following technical scheme:

[0006] A kind of traditional Chinese medicine preparation for treating hyperlipidemia is prepared from the following raw materials: 10-20 g of radix codonopsis, 25-35 g of radix astragali, 10-20 g of gynostemma pentaphyllum, 10-20 g of atractylodes, 3-8 g of zanthoxylum bungeanum, 10-15 g of monascus, and 10-20 g of high-quality ginger.

[0007] Preferably, the following raw medicinal materials are used: Dangshen 15 g, Huangqi 30 g, Jiaogulian 15 g, Baizhu 15 g, Huajiao 5 g, Hongqu 12 g, Gaoliangjiang 15 g.

[0008] The preparation method of the Chinese medicine preparation for treating hyperlipidemia is as follows: the raw medicinal materials are mixed, soaked in water for 20-40 minutes, decocted for 30-50 minutes, and the decoction is poured out, which is the first decoction; the residue is added with water, decocted for 30-50 minutes again, and the decoction is poured out, which is the second decoction; and the two decoctions are mixed together to obtain the Chinese medicine preparation for treating hyperlipidemia.

[0009] Further, the soaking time is 30 minutes.

[0010] Further, the decocting time is 40 minutes.

[0011] The Chinese medicine preparation for treating hyperlipidemia has the following treatment idea: the patients with hyperlipidemia are mostly caused by the deficiency of spleen qi, the internal generation of phlegm turbidity, the blood stasis caused by long-term disease, and the deficiency as an important link in the onset. If the healthy qi is deficient, the blood lipid metabolism is not sufficient, and the blood lipid is condensed in the blood vessels. Therefore, the phlegm, stasis and deficiency are important pathological factors of the disease. Dangshen is sweet and flat, and is returned to the spleen meridian. It can tonify the spleen and nourish the stomach, and can invigorate the middle qi. It can invigorate the spleen without dryness, nourish the stomach without dampness, and can boost the clear yang and invigorate the middle qi without the disadvantages of dryness. The neutral healthy qi is suitable for the five zang organs. Huangqi is sweet and slightly warm, and is a tonic for the healthy qi and the spleen and stomach. The combination of Dangshen and Huangqi can treat the deficiency of the spleen and stomach, invigorate the spleen and stomach, and make the qi and blood unobstructed. Jiaogulian is bitter and slightly sweet, and is cool. It can invigorate the spleen and regulate qi, and can benefit qi and activate blood. Baizhu is bitter and sweet, and is warm. It is returned to the spleen and stomach meridians. It can warm and tonify the healthy qi, invigorate the spleen and benefit qi, and can also dry dampness and drain water. It can treat the blood stasis and the internal generation of phlegm turbidity. Huajiao is pungent and warm. It can enter the spleen to remove dampness, and can enter the right kidney to tonify fire. Its pungent and warm properties can tonify yang qi, and can disperse the cloudy and damp. The addition of Hongqu can invigorate the spleen, benefit qi and warm the middle. It is a symptomatic treatment, and has the effects of reducing blood pressure and blood lipid, activating blood and resolving stasis, invigorating the spleen and digesting food. Gaoliangjiang is pungent and hot, and is a key medicine for removing cold and dampness and warming the spleen and stomach. The combination of all the medicines can enter the spleen and stomach meridians. The onset of hyperlipidemia is caused by the dysfunction of the spleen and stomach. The medicines for reducing blood lipid are also added. The cold and heat are used together, and the healthy qi is tonified. The combination can reduce blood lipid.

[0012] The Chinese medicine preparation for treating hyperlipidemia has the following characteristics:

[0013] 1. Comprehensive regulation, multi-target effect: The traditional Chinese medicine preparation of the present application is different from modern lipid-lowering drugs of single component. It uses multiple Chinese medicines such as radix ginseng, radix astragali, gynostemma pentaphyllum and atractylodes to comprehensively regulate the body's qi and blood, spleen and stomach functions, and promote lipid metabolism to reduce blood lipids. This multi-target and multi-mechanism mode is more in line with the principles of TCM "holistic concept" and "differential treatment", and helps to more comprehensively improve the physical condition of patients with dyslipidemia.

[0014] 2. Selecting monascus to strengthen the lipid-lowering effect: The present application specifically selects monascus as one of the components because monascus is rich in natural statins (such as lovastatin), which have been confirmed by modern research to have significant lipid-lowering effect and are relatively safe with few side effects. Monascus combined with other raw materials such as radix astragali and radix ginseng can not only enhance the overall lipid-lowering effect, but also further promote the metabolism and excretion of blood lipids through mechanisms such as regulating immune function and improving blood circulation, forming a synergistic effect.

[0015] 3. Unique combination of high-quality ginger and zanthoxylum: The traditional Chinese medicine preparation of the present application introduces high-quality ginger and zanthoxylum, which are commonly used in traditional Chinese medicine to warm the center, dispel cold, move qi and relieve pain. However, their ingenious use in the present application reflects a deep understanding of lipid metabolism. High-quality ginger can promote blood circulation and accelerate the removal of lipids from the blood vessel wall, while zanthoxylum can promote digestion and reduce fat absorption. The combination of the two not only helps to improve the distribution and metabolism of blood lipids in the body, but also reduces the generation of blood lipids from the source, embodying the TCM concept of "preventing disease before it occurs". Both are warm herbs, which can prevent the excessive coldness of monascus from affecting the spleen and stomach, and enhance its lipid-lowering effect.

[0016] 4. Synergistic effect of gynostemma pentaphyllum and atractylodes: Gynostemma pentaphyllum is known as "southern ginseng" and has multiple effects such as lowering blood lipids, regulating blood pressure and anti-fatigue. Atractylodes can invigorate the spleen and replenish qi, promote the recovery of spleen and stomach function, and enhance the body's absorption and utilization of nutrients. The combination of the two not only enhances the lipid-lowering effect, but also takes into account the regulation of the spleen and stomach, making the reduction of blood lipids more persistent and stable.

[0017] In summary, the unique features of the traditional Chinese medicine preparation of the present application in lowering blood lipids lie in its comprehensive regulation, multi-target effect, and the use of monascus, high-quality ginger and zanthoxylum, as well as the ingenious combination of gynostemma pentaphyllum and atractylodes, forming a unique lipid-lowering mechanism and effect, providing a safer and more effective TCM treatment for patients with dyslipidemia.

[0018] The traditional Chinese medicine preparation for treating hyperlipidemia of the present application is orally taken (the drug is absorbed through the gastrointestinal mucosa to play a therapeutic role), one dose (the amount of each raw material as described above is the amount of one dose) per day, taken twice, taken half an hour after breakfast and dinner, and continuously taken for 4 weeks as a course of treatment.

[0019] The traditional Chinese medicine preparation for treating hyperlipidemia of the present application is clinically proven to help improve hyperlipidemia, and the serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), etc. of the patients after treatment are significantly better than those of the control group (oral atorvastatin), with statistical significance (P<0.05). The traditional Chinese medicine preparation for treating hyperlipidemia of the present application has remarkable curative effect, good safety, low price and simple prescription, and has high clinical popularization value.

[0020] The various terms and phrases used in the present application have the general meanings known to those skilled in the art. DETAILED DESCRIPTION

[0021] The present application will be further described below in conjunction with examples. However, the scope of the present application is not limited to the following examples. Those skilled in the art can understand that various changes and modifications can be made to the present application without departing from the spirit and scope of the present application.

[0022] The instruments, reagents, and materials involved in the following examples are all conventional instruments, reagents, and materials existing in the prior art, and can be obtained through regular commercial channels, unless otherwise specified. The experimental methods and detection methods involved in the following examples are all conventional experimental methods and detection methods existing in the prior art, unless otherwise specified.

[0023] Example 1 Preparation of a traditional Chinese medicine preparation for treating hyperlipidemia

[0024] The components are as follows: Radix Codonopsis 15 g, Radix Astragali 30 g, Gynostemma pentaphyllum 15 g, Atractylodes 15 g, Zanthoxylum 5 g, Red Yeast Rice 12 g, and Rhizoma Galangae 15 g.

[0025] The preparation method is as follows: the raw materials are mixed, soaked in water for 30 minutes, decocted for 40 minutes, and the decoction is poured out, which is the first decoction; the residue is added with water, decocted for 40 minutes again, and the decoction is poured out, which is the second decoction; the two decoctions are mixed together, and the traditional Chinese medicine preparation for treating hyperlipidemia is obtained.

[0026] Clinical research data

[0027] The research group of the present inventors showed that the present prescription can significantly improve the lipid metabolism related indicators of patients with hyperlipidemia, and has good safety, fully embodies the advantages of traditional Chinese medicine in treating hyperlipidemia, and provides a safe and effective guarantee for the clinical popularization and application of the present invention based on the summary of the inventors' clinical experience for many years.

[0028] 1. Clinical data

[0029] 1.1 Diagnostic criteria

[0030] 1.1.1 Western medicine diagnostic criteria

[0031] According to the "Guidelines for Prevention and Treatment of Dyslipidemia in Chinese Adults (2016 Revised Edition)", the following meets any one of the diagnostic criteria: under normal diet, after fasting for 12-14 h, the total cholesterol is ≥5.2 mmol / L; triglyceride (TG) is ≥1.7 mmol / L and / or low-density lipoprotein cholesterol is ≥3.4 mmol / L; high-density lipoprotein cholesterol (HDL-C) is <1.04 mmol / L.

[0032] 1.1.2 TCM diagnostic criteria and quantitative criteria

[0033] According to the "Guidelines for Clinical Research of Traditional Chinese Medicine New Drugs for Treating Hyperlipidemia", dampness and turbidity obstruction syndrome is selected as the observation syndrome type.

[0034] Main symptoms: dizziness or headache, drowsiness, and increased symptoms on rainy days.

[0035] Secondary symptoms: abdominal distension, vomiting, salivation, heaviness of limbs, sticky mouth without thirst, facial edema, poor appetite, and constipation.

[0036] Tongue and pulse: tongue with tooth marks, greasy fur, and soft pulse.

[0037] According to the tongue and pulse of the patient, one main symptom or two secondary symptoms can be identified as dampness and turbidity obstruction syndrome.

[0038] 1.2 Inclusion criteria

[0039] (1) Meet the above diagnostic criteria;

[0040] (2) Age 25-75 years old, gender not limited;

[0041] (3) No lipid-lowering treatment, and promise not to take other related drugs voluntarily during treatment;

[0042] (4) Voluntarily participate in this study, and can continuously treat for more than 1 month and review blood lipid routine.

[0043] 1.3 Exclusion Criteria

[0044] (1) Patients who are taking other medications;

[0045] (2) Pregnant and lactating women;

[0046] (3) Patients with allergic constitution or allergic to the drug;

[0047] (4) Patients who have suffered from stroke, severe trauma, acute myocardial infarction, severe illness after coronary stent implantation or slow postoperative recovery within 6 months;

[0048] (5) Patients with hyperlipidemia secondary to nephrotic syndrome, hypothyroidism, gout and other diseases;

[0049] (6) Patients with acute cardiovascular and cerebrovascular diseases;

[0050] (7) Patients with hyperlipidemia caused by drug side effects, such as the use of phenothiazines, heparin or other drugs that cause abnormal lipid metabolism;

[0051] (8) Patients with severe dysfunction or primary diseases of liver, kidney, immune system, etc;

[0052] (9) Patients with mental illness, alcohol or drug dependence;

[0053] (10) Patients with malignant tumors or related history.

[0054] 1.4 Termination and Withdrawal Criteria

[0055] (1) Patients who do not use the drug as required during the experiment;

[0056] (2) Patients who have serious adverse reactions or changes in condition;

[0057] (3) Patients who voluntarily withdraw from the experiment;

[0058] (4) Patients who voluntarily take related drugs during treatment. Patients with allergic constitution or allergic to the drug.

[0059] 1.4 Exclusion Criteria

[0060] (1) Patients who are found to be not in line with the inclusion criteria or in line with the exclusion criteria after inclusion;

[0061] (2) Patients who are found to have poor compliance and cannot strictly follow the treatment plan after inclusion;

[0062] (3) Patients who randomly use prohibited drugs during treatment after inclusion.

[0063] 1.5 Dropout Criteria

[0064] (1) Compliance is poor or non-regulated range of combination therapy, affect the efficacy and safety of judgment;

[0065] (2) Allergic reactions or serious adverse events, not suitable for continued treatment;

[0066] (3) Various reasons leading to clinical trials can not continue, quit or stop the trial.

[0067] 1.6General information

[0068] The patients included were from January 2022 to January 2024 in the outpatient department, aged 25-75 years old, diagnosed with hyperlipidemia, a total of 200 cases. Randomized controlled principle is divided into oral traditional Chinese medicine preparation lipid-regulating recipe group, atorvastatin group, each 100 cases. There is no significant difference in age between each group, with baseline consistency (P>0.05).

[0069] 2.Methods

[0070] 2.1Treatment method

[0071] Treatment group: lipid-regulating recipe (i.e. the traditional Chinese medicine preparation of the application, prepared in example 1), 1 dose per day, half an hour after breakfast and dinner. Take continuously for 4 weeks.

[0072] Control group: atorvastatin calcium tablets (Pfizer Pharmaceutical Co., Ltd., 20 mg / tablet), oral, 1 time / night, continuously take for 4 weeks.

[0073] 2.2Observation index

[0074] 2.2.1General information observation

[0075] Observe and record the patient's age, waist circumference, abdominal circumference, body mass index.

[0076] 2.2.2Evaluation of treatment effect (record once before and after treatment)

[0077] Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) were calculated, non-HDL-C=TC-HDL-C.

[0078] 2.2.3Safety evaluation

[0079] Patients should pay attention to monitor blood pressure, heart rate and other vital signs during treatment. Before and after treatment, blood, urine, stool routine and liver and kidney function tests were performed in time.

[0080] 2.3Efficacy determination standard

[0081] 2.3.1Western medical efficacy standard

[0082] TC, TG, LDL-C, non-HDL-C and other lipid metabolism levels are used to judge the treatment effect.

[0083] 2.3.2 TCM efficacy criteria

[0084] TCM symptom score is formulated according to the relevant contents of “Clinical Disease Diagnosis Basis Cure and Improvement Criteria” and “Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine (Trial)”.

[0085] 2.3.3 Safety evaluation criteria

[0086] Grade 1: safe, no adverse reactions. Grade 2: relatively safe, does not affect continued administration and does not require special treatment. Grade 3: safety issues, moderate adverse reactions, can continue administration after treatment. Grade 4: serious adverse reactions, discontinue the trial.

[0087] 2.3.4 Adverse event severity criteria

[0088] Mild: tolerable, does not affect treatment and recovery, and does not require special treatment. Moderate: intolerable, requires immediate discontinuation or special treatment, and has an impact on recovery. Severe: life-threatening, requires immediate discontinuation or emergency treatment.

[0089] 2.4 Medical ethics control

[0090] When patients are included in the clinical study, the researchers inform the patients or their families in detail about the following matters, including the patient's Chinese and Western medical diagnosis, TCM syndrome differentiation type, further treatment plan, expected treatment purpose, and possible adverse reactions. The patient's address and phone number are recorded in detail for clinical follow-up treatment. When the patient's symptoms worsen or discomfort occurs after treatment, the researcher is contacted by phone in a timely manner to stop treatment, symptomatic treatment, and withdraw from the study. The entire process adheres to the principles of voluntary participation and voluntary withdrawal.

[0091] 2.5 Statistical methods

[0092] All data are statistically analyzed using SPSS 26.0 software. Two-sided tests are used for general statistical tests, and differences are considered statistically significant when P<0.05. Count data are described using X 2 tests, frequency, percentage, or constituent ratio; ordinal data are described using constituent ratio or rate; measurement data are first analyzed for normality using K-S tests. Measurement data that meet normality or approximate normality are represented by mean ± standard deviation (X(—)±S), and measurement data that do not meet normality are represented by median (quartile), i.e. M(Q1, Q3). Data that meet normality and homogeneity of variance are tested using t-tests, otherwise rank-sum tests are used.

[0093] 3. Results

[0094] 3.1 General information

[0095] There was no significant difference in gender, height, body mass index, waist circumference, abdominal circumference between the two groups, and the baseline was consistent (P>0.05), as shown in Table 1 and Table 2.

[0096] Table 1 Distribution of gender groups

[0097]

[0098] Table 2 Other general information (X±S)

[0099]

[0100] 3.2 Changes in blood lipid indicators

[0101] There was no significant difference in blood lipid indicators (TC, TG, LDL-C, no-HDL-C) between the two groups before treatment. After treatment, the improvement of TC, TG, and LDL-C in the Tiaozhi Decoction group was significantly better than that in the control group (P<0.05), and no-HDL-C was slightly reduced, but there was no significant difference compared with the control group (P>0.05), as shown in Table 3.

[0102] Table 3 Distribution of main efficacy indicators (mmol / L; X±S)

[0103]

[0104] Note: * P<0.05 for comparison before and after treatment; D P<0.05 for comparison between the two groups after treatment.

[0105] 3.3 Comparison of TCM symptom scores before and after treatment

[0106] There was no significant difference in TCM symptom scores between the two groups before treatment. After treatment, the Tiaozhi Decoction group and the atorvastatin group were improved compared with before treatment (P<0.05), but the comparison between the two groups after treatment showed that the treatment group was significantly better than the control group (P<0.05), as shown in Table 4.

[0107] Table 4 Comparison of TCM symptom scores between the two groups (X±S)

[0108]

[0109] Note: * P<0.05 for comparison between the two groups after treatment.

[0110] 3.4 Adverse reactions

[0111] The liver and kidney functions of the patients in the Tiaozhi recipe group were normal before and after treatment, and the safety was level 1. Three patients in the atorvastatin group had abnormal liver function, and the safety was level 2, and the patients were given symptomatic treatment of liver-protecting drugs.

[0112] 4. Discussion

[0113] The Tiaozhi recipe is composed of Radix Codonopsis 15 g, Radix Astragali 30 g, Gynostemma pentaphyllum 15 g, Atractylodes 15 g, Zanthoxylum 5 g, Monascus 12 g and Alpinia officinarum 15 g.

[0114] Hyperlipidemia has no clear corresponding disease name in traditional Chinese medicine, and its pathogenesis is similar to that of phlegm, obesity, blood stasis, dampness and dizziness, etc. Therefore, it can be based on this. The occurrence of the disease is mostly due to the deficiency of spleen qi, the internal generation of phlegm turbidity, and the blood stasis caused by long-term disease. Deficiency is also an important part of the disease. The deficiency of vital qi leads to the failure of blood lipid metabolism and the aggregation in blood vessels. Based on this, the Tiaozhi recipe is developed. In the recipe, Radix Codonopsis is sweet and flat, and belongs to the spleen meridian. It can tonify the spleen and stomach, and strengthen the middle qi. It can tonify the spleen and stomach without dryness, and nourish the stomach without dampness. It can boost the clear yang and invigorate the middle qi without the disadvantages of dryness. The neutralization of the five zang organs is suitable for the nourishment of the five zang organs. Radix Astragali is sweet and slightly warm, and is a tonic for vital qi and spleen and stomach. The combination of the two can treat the deficiency of hyperlipidemia, support the body and invigorate the spleen and stomach, so that the qi and blood are unobstructed. Gynostemma pentaphyllum is bitter and slightly sweet, and is cool. It can invigorate the spleen and regulate qi, and benefit qi and activate blood. Atractylodes is bitter and sweet, and is warm. It belongs to the spleen and stomach meridians, and can warm and tonify the spleen and stomach, and benefit qi. It can also dry dampness and drain water, and is suitable for blood stasis and internal phlegm turbidity. Zanthoxylum is pungent and warm. It can enter the spleen to remove dampness, and enter the right kidney to supplement fire. Its pungent and warm properties can supplement yang qi, and disperse the cloudy and damp. Monascus can invigorate the spleen, benefit qi and warm the middle. It is also a symptomatic treatment, and has the functions of lowering blood pressure and lipid, activating blood and removing stasis, invigorating the spleen and digesting food. Alpinia officinarum is pungent and hot, and is a key drug for removing cold and dampness and warming the spleen and stomach. The combination of all the drugs can enter the spleen and stomach meridians. The pathogenesis of hyperlipidemia is the dysfunction of the spleen and stomach. The combination of the drugs for lowering lipid and the drugs for removing stasis can supplement yang and benefit qi, and achieve the effect of lowering lipid.

[0115] The clinical research results show that the Tiaozhi recipe can help improve hyperlipidemia, and the treatment effect is better than or not worse than that of the atorvastatin group (P<0.05), which has statistical significance. Especially, the safety is better. The reason is that the Tiaozhi recipe can improve the related clinical symptoms of hyperlipidemia patients in many ways and more safely, and to a certain extent, the treatment effect is strengthened.

[0116] 5. Conclusion

[0117] The Tiaozhi recipe has better or not worse clinical application effect than the commonly used drug atorvastatin calcium, and has good safety, which provides guarantee for the clinical popularization of the Tiaozhi recipe.

[0118] Example 2 Preparation of a Chinese medicine preparation for treating hyperlipidemia

[0119] The prescription is: Dangshen 10 g, Huangqi 35 g, Jiaogulian 10 g, Baizhu 20 g, Huajiao 3 g, Hongqu 15 g, Gaoliangjiang 10 g.

[0120] The preparation method is: mix the raw medicinal materials, soak in water for 20 minutes; decoct for 50 minutes, pour out the medicinal soup, which is the first decoction; add water to the residue, decoct for another 50 minutes, pour out the medicinal soup, which is the second decoction; mix the two decoctions together.

[0121] Example 3 Preparation of a Chinese medicine preparation for treating hyperlipidemia

[0122] The prescription is: Dangshen 20 g, Huangqi 25 g, Jiaogulian 20 g, Baizhu 10 g, Huajiao 8 g, Hongqu 10 g, Gaoliangjiang 20 g.

[0123] The preparation method is: mix the raw medicinal materials, soak in water for 40 minutes; decoct for 30 minutes, pour out the medicinal soup, which is the first decoction; add water to the residue, decoct for another 30 minutes, pour out the medicinal soup, which is the second decoction; mix the two decoctions together.

[0124] Example 4 Preparation of a Chinese medicine preparation for treating hyperlipidemia

[0125] The prescription is: Dangshen 13 g, Huangqi 32 g, Jiaogulian 13 g, Baizhu 18 g, Huajiao 4 g, Hongqu 11 g, Gaoliangjiang 12 g.

[0126] The preparation method is: mix the raw medicinal materials, soak in water for 30 minutes; decoct for 40 minutes, pour out the medicinal soup, which is the first decoction; add water to the residue, decoct for another 40 minutes, pour out the medicinal soup, which is the second decoction; mix the two decoctions together.

[0127] Example 5 Preparation of a Chinese medicine preparation for treating hyperlipidemia

[0128] The prescription is: Dangshen 18 g, Huangqi 28 g, Jiaogulian 18 g, Baizhu 13 g, Huajiao 6 g, Hongqu 14 g, Gaoliangjiang 18 g.

[0129] The preparation method is: mix the raw medicinal materials, soak in water for 30 minutes; decoct for 40 minutes, pour out the medicinal soup, which is the first decoction; add water to the residue, decoct for another 40 minutes, pour out the medicinal soup, which is the second decoction; mix the two decoctions together.

[0130] The foregoing examples are provided to give the skilled person in the art complete disclosure and description of how to make and use the claimed embodiments, and are not intended to limit the scope of what is disclosed herein. Modifications apparent to those skilled in the art are to be within the scope of the claims.

Claims

1. A traditional Chinese medicine preparation for treating hyperlipidemia, characterized in that, Is made of the following raw medicinal materials: Dangshen 10-20 g, Huangqi 25-35 g, Jiaogulian 10-20 g, Baizhu 10-20 g, Huajiao 3-8 g, Hongqu 10-15 g, Gaoliangjiang 10-20 g.

2. The Chinese medicine preparation for treating hyperlipidemia according to claim 1, characterized in that, Is made of the following raw medicinal materials: Dangshen 15 g, Huangqi 30 g, Jiaogulian 15 g, Baizhu 15 g, Huajiao 5 g, Hongqu 12 g, Gaoliangjiang 15 g.

3. The Chinese medicine preparation for treating hyperlipidemia according to claim 1, characterized in that, Is made of the following raw medicinal materials: Dangshen 10 g, Huangqi 35 g, Jiaogulian 10 g, Baizhu 20 g, Huajiao 3 g, Hongqu 15 g, Gaoliangjiang 10 g.

4. The Chinese medicine preparation for treating hyperlipidemia according to claim 1, characterized in that, Is made of the following raw medicinal materials: Dangshen 20 g, Huangqi 25 g, Jiaogulian 20 g, Baizhu 10 g, Huajiao 8 g, Hongqu 10 g, Gaoliangjiang 20 g.

5. The Chinese medicine preparation for treating hyperlipidemia according to claim 1, characterized in that, Is made of the following raw medicinal materials: Dangshen 13 g, Huangqi 32 g, Jiaogulian 13 g, Baizhu 18 g, Huajiao 4 g, Hongqu 11 g, Gaoliangjiang 12 g.

6. The Chinese medicine preparation for treating hyperlipidemia according to claim 1, characterized in that, Is made of the following raw medicinal materials: Dangshen 18 g, Huangqi 28 g, Jiaogulian 18 g, Baizhu 13 g, Huajiao 6 g, Hongqu 14 g, Gaoliangjiang 18 g.

7. The preparation method of the traditional Chinese medicine preparation for treating hyperlipidemia according to any one of claims 1-6, characterized in that: Mix the raw medicinal materials, soak in water for 20-40 minutes, decoct for 30-50 minutes, pour out the medicinal liquor, which is the first decoction; add water to the residue, decoct for another 30-50 minutes, pour out the medicinal liquor, which is the second decoction; mix the two decoctions together, and you get the medicinal liquor.

8. The method of claim 7, wherein: The soaking time is 30 minutes.

9. The method of claim 7, wherein: The decocting time is 40 minutes.

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