A diuresis and dampness-removing medicinal and edible homologous traditional Chinese medicine formula, a preparation method and application thereof

Abstract

The application discloses a water-draining and dampness-dispelling medicinal and edible Chinese medicinal formula and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The water-draining and dampness-dispelling medicinal and edible Chinese medicinal formula comprises coix seed, astragalus root, poria cocos, small red bean, pepper seed, crucian carp, silkworm chrysalis, bean curd and garlic. The coix seed, the astragalus root, the poria cocos, the small red bean, the pepper seed and the crucian carp are used in combination and have the water-draining and dampness-dispelling effect, and the silkworm chrysalis, the bean curd and the garlic are used as supplements. The prepared medicinal and edible Chinese medicinal formula has a good taste, can supplement protein and other nutritional components, has a remarkable water-draining and dampness-dispelling effect on the basis of ensuring the taking compliance, and can be used for the prevention and treatment of various edema diseases.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine, and specifically relates to a medicine-food homologous traditional Chinese medicine formula for promoting water excretion and dispelling dampness, a preparation method and application thereof. BACKGROUND

[0002] Edema is a disease caused by external invasion and internal injury, which leads to dysfunction of lung, spleen and kidney in promoting and distributing water, resulting in water retention in the body and flooding in the skin, and causing clinical symptoms such as edema of head, face, eyelid, limbs, back and even the whole body. Modern clinical diseases include heart failure, pulmonary heart disease, cirrhotic ascites, nephrotic syndrome and lower extremity venous edema. In traditional Chinese medicine, edema is first mentioned in Zhushi Yuanhou Lun.

[0003] Edema is a common clinical symptom. Due to differences in pathogenic factors and constitution, traditional Chinese medicine divides it into yin edema and yang edema, which can be transformed or mixed. Yin edema is mainly caused by damage to spleen and kidney yang qi and abnormal water and dampness metabolism, and is most common in lower limbs. The skin of the edema area is loose and sunken, and it is difficult to recover. In severe cases, it is like mud. Yin edema is common in middle-aged and elderly patients with chronic kidney disease, heart failure and hypoproteinemia, and is mostly deficiency or deficiency and excess. Deficiency is often seen in qi deficiency and yang deficiency, and long-term illness can damage yang and affect yin. Excess is often seen in water and blood stasis. Western medicine believes that edema is a clinical symptom caused by excessive accumulation of body fluid in interstitial tissue, which causes tissue swelling. According to the cause, it can be divided into cardiac edema, renal edema, malnutrition edema and endocrine edema. Patients with nephrotic syndrome, chronic glomerulonephritis, heart failure and hypoproteinemia may have symptoms similar to yin edema.

[0004] Cirrhosis is a common progressive liver disease, and decompensation is mainly manifested as ascites, which is mainly caused by immune hepatitis, alcoholic hepatitis and viral hepatitis. Its pathogenesis is not clear, and modern medicine believes that it is related to liver and kidney function damage, high portal vein pressure, low colloid osmotic pressure and endocrine disorders. Ascites due to cirrhosis belongs to the category of "distension" and "accumulation" in traditional Chinese medicine, which is caused by liver and kidney yin deficiency and water and dampness stagnation, and should be treated by tonifying the spleen and kidney, invigorating qi and blood, nourishing yin and promoting water excretion.

[0005] Journal article ("Effect of Spleen-Kidney Tonifying and Water-Excreting Formula Combined with Traditional Chinese Medicine Acupoint Sticking and Nightly Herbal Diet on Ascites due to Cirrhosis", Wang Xiangcun et al., Henan Medical Research, 2022, No. 13) studies the therapeutic effect of spleen-kidney tonifying and water-excreting formula combined with traditional Chinese medicine acupoint sticking and nightly herbal diet on patients with ascites due to cirrhosis. It is found that the spleen-kidney tonifying and water-excreting formula can enhance the effect, inhibit liver fibrosis and promote liver function recovery, and help alleviate symptoms in patients with ascites due to cirrhosis. The spleen-kidney tonifying and water-excreting formula is composed of many traditional Chinese medicines, which has the functions of tonifying the spleen and kidney and promoting qi and water excretion, and conforms to the principle of treating ascites due to cirrhosis in traditional Chinese medicine.

[0006] Journal literature ("Clinical efficacy analysis of traditional Chinese medicine diuresis recipe combined with diuretics in the treatment of liver and gallbladder damp-heat type cirrhosis ascites", He Dandan, Heilongjiang Medical Science, April 2023) explores the clinical efficacy of traditional Chinese medicine diuresis recipe combined with diuretics in the treatment of liver and gallbladder damp-heat type cirrhosis ascites, and finds that traditional Chinese medicine diuresis recipe combined with diuretics in the treatment of liver and gallbladder damp-heat type cirrhosis ascites can significantly improve liver and kidney function, reduce ascites volume, increase 24h urine volume, and reduce abdominal circumference and body weight, with outstanding curative effect.

[0007] Journal literature ("Influence of Li Shui Rang Gan Decoction and traditional Chinese medicine umbilical application combined with warm acupuncture on liver function, urine volume and portal vein hemodynamics of patients with cirrhosis ascites", Zi Lu et al., Journal of Integrative Chinese and Western Medicine for Liver Disease, January 2021) observes the influence of Li Shui Rang Gan Decoction and traditional Chinese medicine umbilical application combined with warm acupuncture on liver function, urine volume and portal vein hemodynamics of patients with hepatitis B cirrhosis ascites, and finds that after 1 month of treatment, the total effective rate of the observation group is higher than that of the control group, with a statistically significant difference (P<0.05); the improvement degree of liver function and portal vein hemodynamics of the observation group is better than that of the control group, with a statistically significant difference (P<0.05); the abdominal circumference, body weight and ascites dark area depth of the observation group are lower than those of the control group; the 24h urine volume of the observation group is higher than that of the control group, with a statistically significant difference (P<0.05). The results show that Li Shui Rang Gan Decoction and traditional Chinese medicine umbilical application combined with warm acupuncture have good curative effect on patients with hepatitis B cirrhosis ascites, can significantly improve liver function, reduce ascites volume, increase 24h urine volume, and thus reduce abdominal circumference and body weight, and significantly improve the hemodynamics of the portal vein system.

[0008] It can be seen that in the treatment of edema, "eliminating and tonifying" should be used as the method, and tonifying should be given priority to, while tonifying qi, tonifying yang and nourishing yin, combined with diuresis, blood activation and stasis removal, and according to the urgency, or eliminating first and tonifying later, or eliminating and tonifying simultaneously. However, in the prior art, pure traditional Chinese medicine preparations are used for prevention and treatment of edema, and multiple treatment methods need to be combined, the treatment scheme is relatively complex, and the cost is relatively high. Since traditional Chinese medicine tastes bitter, the compliance is poor, and the treatment effect is not ideal. Therefore, it is necessary to provide a medicinal and food homologous traditional Chinese medicine formula for diuresis and dampness removal, which uses different medicinal and food homologous raw materials with diuresis and dampness removal effect, has significant diuresis and dampness removal effect on the basis of ensuring compliance. SUMMARY

[0009] The present application provides a water-removing and dampness-removing medicinal and edible Chinese medicine formula, a preparation method and application thereof, and solves the problems in the prior art.

[0010] To achieve the above object, in a first aspect, the present application provides a water-removing and dampness-removing medicinal and edible Chinese medicine formula, comprising: coix seed, astragalus root, tuckahoe, red bean, pepper nut, crucian carp, silkworm chrysalis, bean curd and garlic.

[0011] The astragalus root can supplement qi, raise yang, remove water and reduce swelling, and produce saliva and nourish blood; the tuckahoe can remove water and dampness, invigorate the spleen, calm the heart and tranquilize the mind; the coix seed can invigorate the spleen and remove dampness, remove water and reduce swelling; the red bean can remove water and reduce swelling, and detoxify and discharge pus; the pepper nut can clear heat and remove urine, and treat kidney deficiency; the crucian carp can benefit qi, invigorate the spleen, remove urine and reduce swelling; the tuckahoe can invigorate the spleen and remove dampness, and treat dampness from the source; and the garlic can warm yang and remove water. The combination of the above-mentioned medicinal and edible Chinese medicines can supplement qi of the spleen and lung, remove water and dry dampness, treat the root of qi deficiency, and treat the symptoms of phlegm-dampness. The silkworm chrysalis is a natural treasure of nutrition, which is rich in protein, oil, minerals, vitamins and other nutrients, and has been regarded as an important source of high-quality protein and fat for a long time. The bean curd is rich in calcium and can improve the taste. The medicinal and edible Chinese medicine formula prepared by the present application has a good taste, can supplement nutrients such as protein, and has a significant water-removing and dampness-removing effect, so that it can be used for the prevention and treatment of various edema diseases.

[0012] In a preferred embodiment, the water-removing and dampness-removing medicinal and edible Chinese medicine formula comprises, by weight fraction: coix seed 10-20 parts, astragalus root 20-40 parts, tuckahoe 10-30 parts, red bean 10-30 parts, pepper nut 10-30 parts, crucian carp 400-600 parts, silkworm chrysalis 2-6 parts, bean curd 5-15 parts and garlic 20-80 parts.

[0013] More preferably, the water-removing and dampness-removing medicinal and edible Chinese medicine formula comprises, by weight fraction: coix seed 15 parts, astragalus root 30 parts, tuckahoe 20 parts, red bean 20 parts, pepper nut 20 parts, crucian carp 500 parts, silkworm chrysalis 3 parts, bean curd 10 parts and garlic 50 parts.

[0014] In a preferred embodiment, the garlic is purple-skin garlic.

[0015] In a second aspect, the present application provides a preparation method of the aforementioned water-removing and dampness-removing medicinal and edible Chinese medicine formula, comprising the following steps:

[0016] S1: grinding coix seed, astragalus root, tuckahoe, red bean and pepper nut into powder to obtain a Chinese medicine powder;

[0017] S2: the crucian carp is scaled, cleaned, and fried in oil until the surface is golden yellow, water, silkworm chrysalis, and garlic are added, the silkworm chrysalis is removed, peeled, mashed, and added to the soup together with the tofu and the Chinese medicinal powder, and then the mixture is stewed to obtain the diuretic and dampness-removing medicinal and edible Chinese medicinal formula.

[0018] In a preferred embodiment, in step S1, the particle size of the Chinese medicinal powder is 80-1000 mesh.

[0019] In a preferred embodiment, in step S2, the mass ratio of the oil to the crucian carp is 5-15:500, and the oil is fried for 3-8 min.

[0020] In a preferred embodiment, in step S2, the volume-mass ratio of the water to the crucian carp is 2-8 mL / g.

[0021] In a preferred embodiment, in step S2, the stewing condition is as follows: stewing for 20-50 min on a low heat.

[0022] In a preferred embodiment, in step S2, after the stewing, a step of adding salt is further included; the mass ratio of the salt to the crucian carp is 2-5:500.

[0023] In a third aspect, the present application provides use of the aforementioned diuretic and dampness-removing medicinal and edible Chinese medicinal formula in the preparation of a product for diuresis and dampness removal.

[0024] In a preferred embodiment, the product includes a product for preventing and treating heart failure, rheumatic heart disease, pulmonary heart disease, ascites due to cirrhosis, nephrotic syndrome, or lower extremity venous edema.

[0025] The present application has the following beneficial effects:

[0026] 1. Huangqi can supplement qi and raise yang, remove water and dissipate swelling, and generate fluid and nourish blood; Fuling can remove water and dampness, invigorate the spleen, calm the heart and tranquilize the mind; Yiyiren can invigorate the spleen, remove dampness, remove water and dissipate swelling; Chixiaodou can remove water and dissipate swelling, and resolve toxins and pus; Jiaomu can clear heat and remove water, and treat kidney deficiency; Crucian carp can benefit qi and invigorate the spleen, remove water and dissipate swelling; Fuling can invigorate the spleen and remove dampness, and treat dampness from the source; and garlic can warm yang and remove water. The combination of the above-mentioned medicinal herbs can supplement the qi of the spleen and lung, remove water and dissipate dampness, and treat the root of qi deficiency and the branch of phlegm-dampness.

[0027] 2. Silkworm chrysalis is a natural treasure house of nutrients, which is rich in protein, oil, minerals, vitamins, and other nutrients, and has been regarded as an important source of high-quality protein and fat for a long time. Tofu is rich in calcium and can improve the taste.

[0028] 3. The medicinal and edible Chinese medicinal formula prepared by the present application has a good taste, can supplement protein and other nutrients, has a significant diuretic and dampness-removing effect, and can be used for the prevention and treatment of various edema diseases. DETAILED DESCRIPTION

[0029] The advantages and features of the present application will become more apparent with the following description of specific embodiments. These embodiments are only exemplary and do not limit the scope of the present application. Those skilled in the art should understand that the details and forms of the technical solutions of the present application can be modified or replaced without departing from the spirit and scope of the present application, and such modifications and replacements fall within the protection scope of the present application.

[0030] It is worth mentioning that the raw materials used in the present application are ordinary commercially available products, and their sources are not specifically limited.

[0031] Example 1

[0032] Preparation of the medicinal and edible homologous traditional Chinese medicine formula for promoting water excretion and removing dampness:

[0033] The composition comprises 15 g of coix seed, 30 g of astragalus root, 20 g of poria cocos, 20 g of red bean, 20 g of pepper, 1 carp of 500 g, 1 cocoon of about 3 g, 10 g of bean curd, and 5 pieces of purple skin garlic of about 50 g;

[0034] The preparation process is as follows:

[0035] S1: grind coix seed, astragalus root, poria cocos, red bean, and pepper to 200 mesh to obtain traditional Chinese medicine powder;

[0036] S2: clean the fish scales and internal organs of the carp, add 10 g of edible oil (corn oil), and fry in oil for 5 min until the surface is golden yellow. Add 2000 mL of water, cocoon, and garlic, boil, remove the cocoon, crush the skin, and add to the soup with bean curd and traditional Chinese medicine powder. Simmer for 30 min over low heat, add 3 g of salt, and the medicinal and edible homologous traditional Chinese medicine formula for promoting water excretion and removing dampness (1 dose) is obtained.

[0037] Example 2

[0038] Preparation of the medicinal and edible homologous traditional Chinese medicine formula for promoting water excretion and removing dampness:

[0039] The composition comprises 15 g of coix seed, 30 g of astragalus root, 20 g of poria cocos, 20 g of red bean, 20 g of pepper, 1 carp of 500 g, 1 cocoon of about 3 g, 10 g of bean curd, and 5 pieces of purple skin garlic of about 50 g;

[0040] The preparation process is as follows:

[0041] S1: grind coix seed, astragalus root, poria cocos, red bean, and pepper to 200 mesh to obtain traditional Chinese medicine powder;

[0042] S2: clean the crucian carp of fish scales and internal organs, add 8g edible oil (soybean oil), oil-fry for 4min until the surface is golden yellow, add 1500mL water, silkworm chrysalis and garlic, boil, take out the silkworm chrysalis, peel, crush and add into the soup together with the beancurd and the Chinese medicinal powder, simmer for 25min on low heat, add 2.5g salt, and the water-removing and dampness-dispelling food-homologous Chinese medicinal formula (1 dose) is obtained.

[0043] Example 3

[0044] Preparation of the water-removing and dampness-dispelling food-homologous Chinese medicinal formula:

[0045] The composition is: 20g of yiyiren, 20g of huangqi, 30g of fuling, 10g of chixiaodou, 30 parts of jaobei, 600g of crucian carp, 1 silkworm chrysalis (about 4g), 15g of beancurd and 8 pieces of zhipidutou garlic (about 80g);

[0046] The preparation process is:

[0047] S1: grind the yiyiren, huangqi, fuling, chixiaodou and jaobei into powder to 200 meshes to obtain the Chinese medicinal powder;

[0048] S2: clean the crucian carp of fish scales and internal organs, add 12g edible oil (peanut oil), oil-fry for 6min until the surface is golden yellow, add 2500mL water, silkworm chrysalis and garlic, boil, take out the silkworm chrysalis, peel, crush and add into the soup together with the beancurd and the Chinese medicinal powder, simmer for 40min, add 3.5g salt, and the water-removing and dampness-dispelling food-homologous Chinese medicinal formula (1 dose) is obtained.

[0049] Comparative Example 1

[0050] Except that 40g of chixiaodou and 0g of jaobei are used, the rest is the same as Example 1.

[0051] Comparative Example 2

[0052] Except that 0g of chixiaodou and 40g of jaobei are used, the rest is the same as Example 1.

[0053] Comparative Example 3

[0054] Except that huangqi is replaced by fangji, the rest is the same as Example 1.

[0055] Comparative Example 4

[0056] Except that huangqi is replaced by zhipidutou garlic, the rest is the same as Example 1.

[0057] Comparative Example 5

[0058] Except that the crucian carp is replaced by carp of the same weight, the rest is the same as Example 1.

[0059] Application Example 1

[0060] Results of rat experiment

[0061] 1. Animals: SD male rats, body weight 200±20g, certificate No. 97A046, provided by the Animal Center of Guangdong Medical College.

[0062] 2. Diuresis experiment: The medicinal and edible Chinese medicine formula of Example 1-3 and Comparative Example 1-5 was stirred, broken and dispersed to be uniform, and the fish bones were removed, and concentrated to a relative density of 1.30 at 25°C, as the drug.

[0063] SD male rats with urine volume collected within 2h accounting for more than 40% of the water volume were selected as experimental objects. 90 SD male rats were randomly divided into 9 groups as control group, Example 1-3 and Comparative Example 1-5 groups. The drug of Example 1-3 and Comparative Example 1-5 groups was administered to the above treated drug of Example 1-3 and Comparative Example 1-5 groups according to 2mL / 100g, and the control group was given physiological sodium chloride solution, and the administration was continued for 7 days. On the 7th day, the rats were fasted for 18h, and water load was given. 0.5h before administration, 30mL / kg of physiological sodium chloride solution was administered by gavage, and the lower abdomen of the rats was squeezed to empty the bladder. After the administration was completed, the rats were placed in a metabolic cage, and the urine volume of each group of rats was counted for 5h, and the results are shown in Table 1.

[0064] Table 1 Results of rat diuresis experiment

[0065] Group Urine volume (mL) Control group 4.08±1.18 Example 1 5.54±0.76** Example 2 5.42±0.71** Example 3 5.47±0.68** Comparative Example 1 4.76±0.91* Comparative Example 2 4.72±0.98* Comparative Example 3 4.63±1.03 Comparative Example 4 4.55±0.89 Comparative Example 5 4.79±1.20*

[0066] Note: * represents P<0.05 compared with the control group; ** represents P<0.01 compared with the control group.

[0067] As can be seen from Table 1, Example 1-3 can significantly increase the 5h urine volume of rats, and has a significant difference compared with the control group. By comparing Example 1 and Comparative Example 1-5, it can be seen that the composition of the medicinal and edible Chinese medicine formula has a great influence on its effect. Among them, Example 1 uses combined use of red bean and pepper nuts, which has better diuretic effect than Comparative Example 1-2 which only uses red bean or pepper nuts; Comparative Example 3 uses radix stephaniae tetrandrae instead of radix astragali, and Comparative Example 4 uses radix astragali instead of purple skin allium victorialis, which will cause the diuretic effect to deteriorate. By comparing Example 1 and Comparative Example 5, it can be seen that the type of fish also has a great influence on the diuretic effect, and in the system of the present application, crucian carp has better technical effect than carp.

[0068] Application Example 2

[0069] Clinical experiment: treatment effect of cirrhosis ascites

[0070] 1. General information and grouping: 92 patients with cirrhotic ascites, aged 32-68 years, with an average age of 48.6±4.3 years, and a disease duration of 6.9±0.2 years, were collected from June 2023 to June 2024, with half males and half females. The above patients were randomly divided into two groups (with the same gender distribution in each group), and there was no significant difference in age and disease duration between the two groups. The control group was treated with routine western medicine (furosemide tablets 20mg, spironolactone tablets 20mg, twice a day), and the example 1 group was given one dose of the water-eliminating and dampness-dispelling medicinal food homologous Chinese medicine formula of example 1, twice a day. Both groups were treated for 4 weeks.

[0071] Inclusion criteria: meet the clinical diagnostic criteria for cirrhotic ascites; family members agree to the content of this study.

[0072] Exclusion criteria: patients who withdraw from treatment; patients with other liver diseases.

[0073] 2. Observation index: 24-hour urine output and 24-hour body weight change, and ascites resolution time were observed. The total effective rate of clinical treatment was observed, and the standard was as follows: symptoms and ascites disappeared, liver function returned to normal for marked effect; symptoms and ascites were relieved, liver function was basically restored to normal for effectiveness; symptoms and ascites were not relieved, and liver function was not restored to normal for no effect. The results are shown in Tables 2-3.

[0074] Table 2 Daily average urine output, body weight change, and ascites resolution time of patients in the two groups

[0075]

[0076] Note: # P<0.01 compared with the control group.

[0077] Table 3 Effective rate of cirrhotic ascites treatment

[0078] Group Effective cases Effective cases Invalid cases Total effective rate / % Control group 14 21 11 76.09 Example 1 36 9 1 97.83*

[0079] Note: * represents P<0.05 compared with the control group.

[0080] From Tables 2-3, compared with the control group, the 24-hour average urine output and 24-hour body weight loss of the patients in the example 1 group were significantly increased, the ascites resolution time was significantly shortened, and the effective rate of cirrhotic ascites treatment was significantly improved, especially the marked effect rate was greatly improved. It can be seen that the medicinal food homologous Chinese medicine formula of example 1 has good water-eliminating and dampness-dispelling effect, and has good treatment effect on cirrhotic ascites.

[0081] The technical scheme of the present application is not limited to the technical means disclosed in the above technical means, and also includes technical schemes composed of any combination of the above technical features. The above is the specific implementation of the present application, and it should be pointed out that for ordinary skilled persons in the technical field, without departing from the principle of the present application, a number of improvements and refinements can be made, which are also considered as the protection scope of the present application.

Claims

1. A pharmafood Chinese medicine composition for liver cirrhosis ascites for promoting urination and removing dampness, characterized in that, The composition comprises, by weight, 10-20 parts of coix seed, 20-40 parts of astragalus, 10-30 parts of poria, 10-30 parts of red bean, 10-30 parts of pepper, 400-600 parts of crucian, 2-6 parts of silkworm chrysalis, 5-15 parts of bean curd, and 20-80 parts of garlic. 2.The medicinal and edible traditional Chinese medicine composition of claim 1, characterized in that, The composition comprises, by weight, 15 parts of coix seed, 30 parts of astragalus, 20 parts of poria, 20 parts of red bean, 20 parts of pepper, 500 parts of crucian, 3 parts of silkworm chrysalis, 10 parts of bean curd, and 50 parts of garlic. 3.The medicinal and edible traditional Chinese medicine composition of claim 1, characterized in that, The garlic is purple-skin garlic.

4. The preparation method of the medicinal and edible traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The method comprises the following steps: S1: grinding coix seed, astragalus, poria, red bean, and pepper into powder to obtain traditional Chinese medicine powder; S2: frying crucian in oil until the surface of the crucian is golden yellow, adding water, silkworm chrysalis, and garlic, boiling, taking out the silkworm chrysalis, peeling and crushing the silkworm chrysalis, and adding the crushed silkworm chrysalis, bean curd, and traditional Chinese medicine powder into the soup to obtain the composition.

5. The production method according to claim 4, wherein In step S1, the particle size of the traditional Chinese medicine powder is 80-1000 mesh; in step S2, the mass ratio of oil to crucian is 5-15:500; and the oil is fried for 3-8 minutes.

6. The production method according to claim 4, wherein In step S2, the volume-mass ratio of water to crucian is 2-8 mL / g; and the stewing condition is: stewing for 20-50 minutes on a low heat.

7. The production method according to claim 4, wherein In step S2, after stewing, a step of adding salt is further included; and the mass ratio of salt to crucian is 2-5:

500.

8. Use of the diuresis and dampness-eliminating medicinal and edible traditional Chinese medicine composition according to any one of claims 1-3 or the medicinal and edible traditional Chinese medicine composition prepared by the preparation method according to any one of claims 4-7 in the preparation of a health food or a medicine for liver cirrhosis ascites.

Images