A multi-wavelength medical laser scalpel device

Abstract

The application provides a kind of multi-wavelength medical laser knife device, which comprises a multi-wavelength laser source, a transmission control module, a wide-spectrum high-pass transmitter and an output module. The laser output by the multi-wavelength laser source is transmitted to the wide-spectrum high-pass transmitter through the transmission control module, and the required laser is output by the output module and acts on the target biological tissue after being selected and controlled. The application can realize the demand for high-pass (T>80%) output of ultra-wide spectrum laser (100 nm~3 mm), and can realize the multi-functional working mode of single-wavelength output, multi-wavelength simultaneous output, different spot size output and different transmission device output. The transmission efficiency is high, the structure is compact, and it can simultaneously meet various application scenarios, improve the use compatibility of the equipment and reduce the cost. The application can also automatically select the working mode of the laser according to the database to achieve the effect of different application scenarios.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical instruments, in particular to a multi-wavelength medical laser knife device. BACKGROUND

[0002] High-precision, low collateral damage laser can be used as a laser knife, which has important application value in biological and medical fields such as tissue cell separation and precise surgery. For example, the 488 nm ~ 515 nm visible light radiated by an argon ion laser can be absorbed by hemoglobin in blood, causing good coagulation of blood in blood vessels and achieving good hemostatic effect; the 1064 nm near-infrared laser has strong penetration ability in human tissues, can penetrate deeply into the inside of the tissue, and can cause protein coagulation to achieve a therapeutic effect; the 6.45 μm mid-infrared laser has attracted widespread attention due to its special effect on water and protein, and based on the dual effect of protein structure denaturation and water absorption provided by the laser ablation mechanism, the collateral damage of the laser used for cutting in central nervous tissue and eye parts is extremely small, and can reach the single cell level; the 10.6 μm far-infrared laser radiated by a CO2 laser can be almost completely absorbed by water in human tissues, and the optical energy is converted into heat energy, causing the diseased tissue to dehydrate, vaporize and coagulate without bleeding, and can be used in many aspects of surgery.

[0003] However, the existing laser knives are mostly based on a single wavelength laser provided by a single laser source, and the application scenarios are limited; or based on laser frequency conversion technology to provide wavelength tunable laser, which is limited by the crystal aperture and the crystal damage threshold, and has a short wavelength tuning range; or based on multiple independent lasers combined to realize multi-wavelength operation, which has a complex structure, low transmission efficiency, and is not convenient for practical use. Therefore, it is urgent to develop a multi-wavelength laser scalpel that can stably and efficiently realize ultra-wide spectrum laser output, and can realize multiple working modes, has a compact structure and is easy to maintain, so as to meet the needs of different application scenarios. SUMMARY

[0004] (I) Invention purpose

[0005] The purpose of the present application is to provide a multi-wavelength medical laser scalpel device and a use method thereof, which can realize efficient output of ultra-wide spectrum laser and multiple working modes, and can meet the needs of multiple application scenarios.

[0006] (II) Technical solutions

[0007] To solve the above problems, the present application provides a multi-wavelength medical laser scalpel device, comprising:

[0008] a multi-wavelength laser source, a transmission control module, a wide spectrum high-pass transmitter and an output module arranged in sequence along the light path direction;

[0009] The multi-wavelength laser source comprises a plurality of lasers for providing laser beams of different wavelength bands covering a spectrum range of 100 nm to 3 mm;

[0010] The transmission control module is located at a laser exit end of the multi-wavelength laser source and is configured to change a transmission direction of the laser beams emitted by the multi-wavelength laser source and couple the required laser beams into one end of the wide-spectrum high-pass transmission device.

[0011] The wide-spectrum high-pass transmission device is configured to control selected parameters of the laser beams coupled into the wide-spectrum high-pass transmission device and transmit the selected laser beams to the output module, wherein the controlled parameters of the laser beams include wavelength, line width, power and transmittance.

[0012] The output module comprises a beam guiding assembly and an output end assembly which are sequentially and sealingly connected, the laser beams emitted from the wide-spectrum high-pass transmission device are injected into the beam guiding assembly, shaped and transmitted, and then output by the output end assembly.

[0013] Optionally, the wide-spectrum high-pass transmission device comprises two high-pass mirrors arranged oppositely, a high-pass controller, a sealed cavity, two window mirrors, a high-pass waveguide and a detection feedback system.

[0014] The sealed cavity provides a low-loss environment for transmission of the multi-wavelength laser beams and is configured to reduce laser loss caused by air absorption, the sealed cavity has an input end and an output end arranged oppositely, and two window mirrors are arranged at the input end and the output end for coupling in and out of the multi-wavelength laser beams.

[0015] The two high-pass mirrors are located in the sealed cavity, and the positions of the two high-pass mirrors are controlled by the high-pass controller to control the selection of the multi-wavelength laser beams coupled into the sealed cavity.

[0016] The high-pass waveguide is connected to the window mirror at the output end of the sealed cavity and is configured to transmit the laser beams transmitted through the sealed cavity.

[0017] The detection feedback system is located at the output end of the output module and is configured to detect, analyze and feedback the parameters of the output laser beams, target biological tissues and clinical data, and control the high-pass controller and the transmission control module.

[0018] Optionally, the two high-pass mirrors are made of any one of diamond and silicon wafer, so that the transmission spectrum range of the two high-pass mirrors covers the ultraviolet, visible, infrared and terahertz bands.

[0019] Different regions on the inner surface of the high-pass mirror near the input end of the sealed cavity are coated with high-reflection films of different wavelength bands, and corresponding regions on the inner surface of the high-pass mirror near the output end of the sealed cavity are coated with partial-reflection films of corresponding wavelength bands.

[0020] Optionally, the two high-pass mirrors are arranged on an adjustment module, the adjustment module is located in the sealed cavity, and the adjustment module comprises two adjustment tables arranged oppositely, two supports and a displacement assembly.

[0021] Two high-pass mirrors are arranged on two adjusting tables, and the two adjusting tables are fixed on the displacement assembly through two supports. The rotation, horizontal movement, vertical movement of the two high-pass mirrors are controlled by the high-pass controller, and the distance between the two high-pass mirrors is adjusted.

[0022] The displacement assembly comprises a sliding rail and a sliding block arranged on the sliding rail, and the support is arranged on the sliding block. Alternatively, a PZT piezoelectric ceramic sheet is arranged on the support, and the scanning voltage applied to the PZT piezoelectric ceramic sheet is changed by the high-pass controller to move the two high-pass mirrors.

[0023] Optionally, the sealed cavity adopts a double-cavity structure, and the area between the two cavities is vacuum, and the inner cavity is filled with protective gas to form an internal and external pressure difference.

[0024] The two window mirrors adopt any one of diamond material or silicon wafer, so that the transmission spectrum range of the sealed cavity covers ultraviolet, visible light, infrared and terahertz wave bands.

[0025] Optionally, the connection end of the high-pass waveguide and the sealed cavity is regular horn-shaped or special-shaped, which is used for collecting the laser emitted from the sealed cavity into the output module.

[0026] The high-pass waveguide is any one of a crystal with high transmittance to output laser, a metal waveguide with high reflectivity, or a quartz waveguide coated with a high-reflectivity metal film.

[0027] Optionally, the detection feedback system comprises a detector and an analysis controller.

[0028] The detector is used to detect the output laser parameters, biological tissues and clinical data. The detected laser parameters include wavelength, power, transmittance, repetition frequency, pulse width, line width and spot size. The detected biological tissues and clinical data include the size of the ablated tissue area and the accompanying damage, and are transmitted to the analysis controller.

[0029] The analysis controller compares and analyzes the detected data and the set data, and then feeds back a signal to control the transmission control module and the high-pass controller. The analysis controller is also used to collect and store data to form a database. The information in the database includes target biological tissue type, target biological tissue size, operation time, laser working parameter and action time.

[0030] Optionally, the beam guiding assembly is connected to the wide-spectrum high-pass transmitter. The beam guiding assembly is any one of a mechanical arm and an optical fiber, and can control the laser spot size.

[0031] The output end assembly is used to apply the output required laser to the target biological tissue. The output end assembly is any one of a laser pen knife, a puncture needle and a free-space output.

[0032] Optionally, a method for using a multi-wavelength medical laser knife device comprises:

[0033] According to the required biological tissue, the working mode of the output module is determined;

[0034] The laser working parameters, target biological tissue and clinical data are set, wherein the laser working parameters include wavelength, power, repetition frequency, line width, pulse width and spot size, and the target biological tissue and clinical data include the size of the ablation tissue area and the allowable collateral damage;

[0035] The transmission control module is started to couple the multi-wavelength laser containing the required wavelength into the wide spectrum transmitter, the wide spectrum transmitter controls the laser parameters coupled into the wide spectrum transmitter according to the set laser working parameters, and then the output module outputs the laser to ablate the target biological tissue.

[0036] Optionally, the multi-wavelength medical laser knife device further comprises two high-pass mirrors, a high-pass controller, a sealed cavity, a high-pass waveguide, a detector and an analysis controller, the transmission control module is started to couple the multi-wavelength laser containing the required wavelength into the wide spectrum transmitter, the wide spectrum transmitter controls the laser parameters coupled into the wide spectrum transmitter according to the set laser working parameters, and then the output module outputs the laser to ablate the target biological tissue, comprising:

[0037] The transmission control module is started to couple the multi-wavelength laser containing the required wavelength into the sealed cavity, the high-pass controller controls the positions of the two high-pass mirrors so that the multi-wavelength laser containing the required wavelength is coated with a reflective film of the required wavelength band in the incident area of the two high-pass mirrors, the required wavelength laser is output after multiple reflections between the two high-pass mirrors, and then is output through the high-pass waveguide and the output module, and finally acts on the target biological tissue, the detector detects the output laser parameters, biological tissue and clinical data, the detector transmits the detection results to the analysis controller, and then feeds back signals to control the transmission control module and the high-pass controller;

[0038] The above steps are repeated to optimize the transmission control module and the two high-pass mirrors until the data detected by the detector and the set data are consistent, and the transmittance of the wavelength laser reaches more than 80%;

[0039] The output module continues to work to apply the selected laser to the target biological tissue for laser ablation, and the analysis controller collects and stores data including the target biological tissue type, target biological tissue size, operation time, laser working parameters and action time to form a database;

[0040] The multi-wavelength medical laser knife can realize manual input work or automatic work according to the database data.

[0041] (III) Beneficial effects

[0042] The above technical solutions of the present application have the following beneficial technical effects:

[0043] 1、In the present application, by controlling the wide-spectrum high-pass transmitter, the wavelength, line width and transmittance of the transmitted laser can be selected and controlled, realizing efficient transmission of multi-wavelength laser.

[0044] 2、In some embodiments, two high-pass mirrors with partitioned coating can realize high-pass transmission of laser, with high transmission efficiency (T>80%);

[0045] 3、In some embodiments, two high-pass mirrors with partitioned coating can also meet the output requirements of ultra-wide-spectrum multi-wavelength laser knives (100 nm~3 mm);

[0046] 4、In some embodiments, by changing the beam steering assembly, fiber output, mechanical arm output or free space output can be realized, and the output spot size can be tuned, multi-wavelength medical laser knives realize multiple working modes, which can meet multiple application scenarios at the same time, improve the use compatibility of the equipment, and reduce the cost;

[0047] 5、In some embodiments, a database is further included, which can automatically select the working mode of the multi-wavelength medical laser knife according to different application scenarios, i.e., different lesion positions, different sizes and operation time. BRIEF DESCRIPTION OF DRAWINGS

[0048] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required by the embodiments will be briefly introduced as follows.

[0049] Figure 1 is a structural schematic diagram of a multi-wavelength medical laser knife device provided by the present application;

[0050] Figure 2 is a structural schematic diagram of a sealed cavity in a multi-wavelength medical laser knife device provided by the present application;

[0051] Figure 3 is a structural schematic diagram of an adjusting module in a multi-wavelength medical laser knife device provided by the present application;

[0052] Figures 4-7 is a schematic diagram of the coating shape of two high-pass mirrors in a multi-wavelength medical laser knife device provided by the present application;

[0053] Figure 8 is a flowchart of a use method of a multi-wavelength medical laser knife device provided by the present application;

[0054] Figure 9is a structural schematic view of a multi-wavelength medical laser knife device of the first embodiment provided by the present application;

[0055] Figure 10 is a schematic view of an output module of the first embodiment provided by the present application;

[0056] Figure 11 is a structural schematic view of a multi-wavelength medical laser knife device of the second embodiment provided by the present application;

[0057] Figure 12 is a schematic view of an output module of the second embodiment provided by the present application;

[0058] Reference signs:

[0059] 1-multi-wavelength laser source; 2-transmission control module; 3-wide spectrum high-pass controller; 31-high-pass mirror; 32-high-pass controller; 33-sealed cavity; 34-window mirror; 35-high-pass waveguide; 36-detection feedback system; 361-detector; 362-analysis controller; 4-output module; 41-beam guiding module; 42-output end module; 5-adjustment module; 51-adjustment table; 52-bracket; 53-displacement assembly; 531-sliding block; 532-sliding rail. DETAILED DESCRIPTION

[0060] In order to make the objects, technical solutions and advantages of the present application clearer, further detailed description will be made to the present application with reference to the specific embodiments and the accompanying drawings. It should be understood that these descriptions are only exemplary and are not intended to limit the scope of the present application. In addition, in the following description, the description of the known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present application.

[0061] The present application will be described in detail below with reference to the accompanying drawings and embodiments. Figures 1-12

[0062] Please refer to Figures 1-8 As shown in the figure, the present application provides a multi-wavelength medical laser scalpel device, which comprises a multi-wavelength laser source 1, a transmission control module 2, a wide spectrum high-pass transmitter 3 and an output module 4.

[0063] The multi-wavelength laser source 1 comprises a plurality of lasers for providing lasers of different wavebands. The multi-wavelength laser source 1 can comprise lasers of multiple wavebands in ultraviolet laser source, visible light source, near-infrared laser source, short-wave infrared laser source, medium and far-infrared laser source, and terahertz source, and the wavelength can cover a super wide spectrum range of 100 nm~3 mm. The type of multi-wavelength laser source is not limited by the present application, for example, it can be continuous laser, long pulse laser or short pulse laser.

[0064] ​The transmission control module 2 is located at the exit end of the multi-wavelength laser source 1, used for changing the transmission direction of the laser emitted by the multi-wavelength laser source 1, and coupling the emitted laser into one end of the wide-spectrum high-pass transmitter 3; the transmission control module 2 can include a plurality of laser reflecting mirrors or a beam splitter that simultaneously reflects part of the wavelength laser and transmits other wavelength laser, and the mirror is movable in space, used for transmitting the required wavelength laser to the center position of the wide-spectrum high-pass transmitter 3 as much as possible, so as to reduce the loss or deformation caused by edge transmission in the process of laser beam propagation.

[0065] The wide-spectrum high-pass transmitter 3 is used for selecting and controlling the laser parameters coupled into it, and transmitting the selected laser to the output module, wherein the controlled laser parameters include wavelength, line width, power and transmittance, so as to realize efficient transmission of multi-wavelength laser.

[0066] In some embodiments, the wide-spectrum high-pass transmitter 3 includes two high-pass mirrors 31 arranged oppositely, a high-pass controller 32, a sealed cavity 33, two window mirrors 34, a high-pass waveguide 35 and a detection feedback system 36.

[0067] The sealed cavity 33 provides a low-loss environment for the transmission of multi-wavelength laser, used for reducing the laser loss caused by air absorption; the sealed cavity 33 adopts a double-cavity structure, i.e. an outer cavity in vacuum and an inner cavity in positive pressure, forming an internal and external pressure difference, reducing the requirement for vacuum degree, and the positive pressure difference in the inner cavity can inhibit the overflow of device molecules, used for reducing laser loss, achieving the effects of protection and low-temperature insulation, and the structure of the sealed cavity 33 is as shown in Figure 2 The sealed cavity 33 is made of stainless steel material resistant to high and low pressure.

[0068] The sealed cavity 33 has an input end and an output end arranged oppositely, and two window mirrors 34 are arranged at the input end and the output end, used for coupling input and output of multi-wavelength laser; in order to realize super-wide spectrum laser input and output, the two window mirrors 34 are made of any one of diamond material or silicon wafer, so that the transmission spectrum range of the sealed cavity 33 covers ultraviolet, visible light, infrared and terahertz wave bands.

[0069] The two high-pass mirrors 31 are placed oppositely inside the sealed cavity 33, and the positions of the two high-pass mirrors are controlled by the high-pass controller, so as to select and control the multi-wavelength laser coupled into the sealed cavity; the material of the two high-pass mirrors is any one of diamond or silicon wafer, so that the transmission spectrum range of the two high-pass mirrors covers ultraviolet, visible light, infrared and terahertz wave bands.

[0070] In some embodiments, the two high-pass mirrors 31 are coated with films in different regions on two opposite surfaces, that is, different regions on the inner surface of the high-pass mirror 31 near the input end of the sealed cavity 33 are coated with high-reflection films of different wavebands, and the corresponding regions on the inner surface of the high-pass mirror 31 near the output end of the sealed cavity 33 are coated with partial-reflection films of the corresponding wavebands; the reflection films can be single-wavelength or film systems covering a wide spectrum, which can be set according to actual application requirements; the shapes of the two high-pass mirrors are not limited in the present application, for example, they can be any one of a circle, a square, etc.; the shapes of the reflection films can be at least one of a circle, a square, a circular ring, a sector, or any shape, to meet different application requirements; the size of the reflection film needs to be larger than the size of the incident laser to avoid causing laser loss. In the present embodiment, the two high-pass mirrors coated with films in different regions can meet the transmission of wide-spectrum multi-wavelength lasers. Figures 4-7

[0071] In some embodiments, the two high-pass mirrors 31 are arranged on the adjustment module 5, the adjustment module 5 is located in the sealed cavity 33, and the adjustment module 5 includes two adjustment platforms 51, two supports 52, and a displacement assembly 53, as shown in the structure of the adjustment module 5. Figure 3 The two high-pass mirrors 31 are arranged on the two adjustment platforms 51 respectively, the two adjustment platforms 51 are arranged on the displacement assembly 53 through the two supports 52, the adjustment module 5 is controlled by the high-pass controller 32 to drive the two high-pass mirrors 31 to rotate, move horizontally, move vertically, and change the distance between the two high-pass mirrors 31, so that the required wavelength laser is coated with the reflection film of the corresponding waveband in the incident region of the two high-pass mirrors 31, the laser is reflected multiple times between the two high-pass mirrors 32, and is output after meeting the condition of constructive interference of the reflected light between the two high-pass mirrors, to adjust the wavelength, line width, and power of the laser coupled out of the sealed cavity 33, and the laser transmission rate is greater than 80%, so that the output laser parameters meet the actual application requirements. Among them, the two high-pass mirrors 31 are driven to rotate by the two adjustment platforms 51 with the center o as the center in the xoy plane, are driven to move vertically along the y axis by the two supports 52, are driven to move horizontally along the x axis by the displacement assembly 53, and change the distance between the two high-pass mirrors 31 along the z axis. In the present embodiment, the two high-pass mirrors coated with films in different regions can meet the efficient transmission of wide-spectrum multi-wavelength lasers by precise control.

[0072] In a specific embodiment, the displacement assembly 53 includes a sliding rail 532 and a sliding block 531 arranged on the sliding rail 532, and the two supports 52 are arranged on the two sliding blocks 531 respectively. The position of the sliding block 531 can be controlled by the high-pass controller 32 to make the two high-pass mirrors 31 move horizontally and change the distance therebetween.

[0073] ​In another specific embodiment, a PZT piezoelectric ceramic sheet is arranged on at least one support 52, and the scanning voltage applied to the PZT piezoelectric ceramic sheet is changed by the high-pass controller 32 to move the two high-pass mirrors 31 horizontally and change the distance between the two high-pass mirrors.

[0074] The high-pass waveguide 35 is connected to the window mirror 34 at the output end of the sealed cavity 33, and the connection end is regularly horn-shaped or shaped, wherein the shaped shape includes an irregular shape that can collect the laser emitted from the sealed cavity 33 into the output module 4.

[0075] The high-pass waveguide 35 can be any one of a crystal having high transmittance to the output laser, a metal waveguide having high reflectivity, or a quartz waveguide coated with a high-reflectivity metal film, for transmitting the selected multi-wavelength laser.

[0076] The detection feedback system 36 includes a detector 361 and an analysis controller 362, the detector 361 is used to detect the output laser parameters, target biological tissues and clinical data, including wavelength, power, transmittance, repetition frequency, pulse width, line width, and spot size, and the detected biological tissues and clinical data include the size of the ablated tissue area and the accompanying damage, and are transmitted to the analysis controller 362; the analysis controller 362 compares and analyzes the detected data and the set data, and then feeds back a signal to control the transmission control module 2 and the high-pass controller 32, and is used to collect and store data to form a database, and the information of the database includes target biological tissue type, target biological tissue size, operation time, laser working parameter, and action time.

[0077] The output module 4 is connected to the other end of the high-pass waveguide 35, and includes a beam guiding assembly and an output end assembly connected in sequence, the laser emitted from the wide-spectrum high-pass transmitter is injected into the beam guiding assembly for shaping transmission, and then output by the output end assembly. The beam guiding assembly 41 is used for transmitting laser, and can be any one of a mechanical arm and an optical fiber, and can control the laser spot size; the output end assembly 42 is used for outputting the required laser to act on the target biological tissue, and can be any one of a laser pen knife, a puncture needle, and a free-space output; the beam guiding assembly 41 and the output end assembly 42 are connected in sequence and optically coaxial, and the connection place can be rotated and adjusted at any angle to meet the flexible working requirement of the multi-wavelength medical laser knife.

[0078] The application also provides a use method of the multi-wavelength medical laser knife device, which is used for the multi-wavelength medical laser knife device of any one of the above-mentioned embodiments, and please refer to Figure 8 The use method comprises the following steps:

[0079] In step 100, the working mode of the output module is determined according to the required action biological tissue.

[0080] In this step, since the multi-wavelength medical laser knife device can act on various biological tissues, before starting, the working mode of the light beam guiding assembly 41 and the output end assembly 42 needs to be determined according to the specific biological tissue type and size.

[0081] In step 200, laser working parameters, target biological tissues and clinical data are set, wherein the laser working parameters include wavelength, power, repetition frequency, line width, pulse width and spot size, and the target biological tissues and clinical data include the size of the ablation tissue region and the allowable collateral damage.

[0082] In this step, the required laser working parameters are determined according to the type of tissue to be acted on, and the laser working parameters, target biological tissues and allowable clinical data are set in the analysis controller 362.

[0083] In step 300, the transmission control module is started to couple the multi-wavelength laser containing the required wavelength into the wide spectrum transmitter, the wide spectrum transmitter controls the laser parameters coupled into the wide spectrum transmitter according to the set laser working parameters, and then the output module outputs to ablate the target biological tissue.

[0084] In some embodiments, step 300 specifically includes:

[0085] The transmission control module 2 is started to couple the multi-wavelength laser containing the required wavelength into the sealed cavity 33 close to the center of the wide spectrum transmitter 3, and the high-pass controller 32 controls the rotation, horizontal movement, vertical movement and distance between the two high-pass mirrors 31, so that the multi-wavelength laser containing the required wavelength is coated with a reflective film of the required wavelength band in the incident area of the two high-pass mirrors 31, and the required wavelength laser is output after multiple reflections between the two high-pass mirrors 31, and then output through the high-pass waveguide 35 and the output module 4, and then exit to act on the target biological tissue. The output laser parameters, biological tissues and clinical data are detected by the detector 361, the detector 361 transmits the detection results to the analysis controller 362, and then the analysis controller 362 feeds back signals to the transmission control module 2 and the high-pass controller 32 to control their work;

[0086] The above steps are repeated to optimize the positions of the transmission control module 2 and the two high-pass mirrors 31 until the data detected by the detector 361 is consistent with the set data, and the transmittance of the laser of this wavelength is more than 80%;

[0087] The output module 4 continues to work to act the selected laser on the target biological tissue for laser ablation; the analysis controller 362 collects and stores data, including target biological tissue type, target biological tissue size, operation time, laser working parameters and action time, to form a database.

[0088] The multi-wavelength medical laser scalpel provided by the application can realize manual input work or automatic work according to database data, can meet the demand of high-pass (T>80%) output of super wide spectrum laser (100 nm-3 mm), and can realize multi-functional work modes of single-wavelength output, multi-wavelength simultaneous output, different spot size output and different transmission device output, has high transmission efficiency and compact structure, can meet multiple application scenarios at the same time, improves the use compatibility of the equipment and reduces the cost.

[0089] The multi-wavelength medical laser scalpel device of the application is described below with several specific embodiments.

[0090] Embodiment 1

[0091] Figure 9 The structure diagram of the multi-wavelength medical laser scalpel device of the first embodiment provided by the application, the embodiment provides a multi-wavelength medical laser scalpel device, which comprises a multi-wavelength laser source 1, a transmission control module 2, a wide spectrum high-pass transmission device 3 and an output module 4.

[0092] The multi-wavelength laser source 1 is used for providing laser beams of different wave bands, and in the embodiment, six wide band lasers are provided, including a 266 nm ultraviolet laser 11, a 750-850 nm tunable titanium sapphire laser 12, a 980-1300 nm near-infrared laser 13, a 2 μm short wave infrared laser 14, a 6 μm medium infrared laser 15 and a 10.6 μm CO2 laser 16, all of which are continuous light outputs.

[0093] The transmission control module 2 comprises seven 45° mirrors / partial reflection and partial transmission mirrors, and the spatial positions of the mirrors are movable, which are used for shooting the laser beams emitted by the multi-wavelength laser source 1 into the center of the wide spectrum high-pass transmission device 3, so as to reduce the loss or deformation caused by the edge transmission in the process of laser beam propagation.

[0094] The wide spectrum high-pass transmission device 3 is used for selecting and controlling the laser parameters coupled into the device, and transmitting the selected laser beams to the output module 4, wherein the controlled laser parameters include wavelength, line width, power and transmittance. The wide spectrum high-pass transmission device 3 comprises two high-pass mirrors 31, a high-pass controller 32, a sealed cavity 33, two window mirrors 34, a high-pass waveguide 35 and a detection feedback system 36.

[0095] The sealed cavity 33 provides a low-loss environment for multi-wavelength laser transmission, which is used for reducing the laser loss caused by air absorption; the sealed cavity 33 adopts a double-cavity structure, that is, an outer cavity is vacuumized and an inner cavity is filled with gas for protection, so that an internal and external pressure difference is formed, the vacuum degree requirement is reduced, the inner cavity positive pressure difference can inhibit the overflow of device molecules, which is used for reducing the laser loss, and the effects of protection and low-temperature heat insulation are realized. The structure of the sealed cavity 33 is as shown in Figure 2The sealing cavity 33 is made of stainless steel material with high and low pressure resistance.

[0096] The sealing cavity 33 has opposite input and output ends, and two window mirrors 34 are arranged at the input and output ends for coupling input and output of multi-wavelength laser. In order to meet the input and output of ultra-wide spectrum laser, the two window mirrors 34 are made of diamond material or silicon wafer, so that the transmission spectrum range of the sealing cavity 33 covers the wavelength range of the multi-wavelength laser source 1.

[0097] Two high-pass mirrors 31 are arranged in the sealing cavity 33 in opposite parallel, both of which are circular diamond plane mirrors with a diameter of 25.4 mm to meet the transmission requirements of the multi-wavelength laser source 1. The opposite surfaces of the two high-pass mirrors 31 are divided into six coating areas, as shown in Figure 4 The coating diagram of the two high-pass mirrors 31 is shown in the figure. The two high-pass mirrors are uniformly divided into six fan-shaped coating areas, which are respectively coated with reflective films of 266 nm, 750-850 nm, 980-1300 nm, 2 μm, 6 μm and 10.6 μm laser. That is, the inner surface of the high-pass mirror 31 near the incident end of the sealing cavity 33 is coated with high-reflection films of different wavebands in six different areas, and the inner surface of the high-pass mirror 31 near the exit end of the sealing cavity 33 is coated with partial-reflection films of corresponding wavebands in six corresponding areas, so as to realize the required wavelength laser to be reflected multiple times between the two high-pass mirrors and then exit from the high-pass mirror 31 near the exit end of the sealing cavity 33. The coating area is much larger than the size of the incident laser of the corresponding waveband, so as to avoid causing laser loss.

[0098] The two high-pass mirrors 31 are arranged on the adjusting module 5, and the adjusting module 5 is located in the sealing cavity 33. The adjusting module 5 includes two adjustment tables 51 arranged opposite to each other, two supports 52 and a displacement assembly 53, as shown in Figure 3 The two high-pass mirrors 31 are arranged on the two adjustment tables 51 respectively, and the two adjustment tables 51 are arranged on the displacement assembly 53 through the two supports 52. The adjusting module 5 is controlled by the high-pass controller 32 to drive the two high-pass mirrors 31 to rotate, move horizontally and move vertically, and change the distance between the two high-pass mirrors 31, so that the required wavelength laser is coated with reflective films of corresponding wavebands in the incident area of the two high-pass mirrors 31, and the laser is reflected multiple times between the two high-pass mirrors 31 and then outputted to meet the conditions of constructive interference of the reflected light between the two high-pass mirrors 31, so as to adjust the wavelength, line width and power of the laser coupled out of the sealing cavity 33, and the laser transmittance is greater than 80%, so that the output laser parameters meet the actual application requirements. Among them, the two adjustment tables 51 rotate in the plane with the center o as the center to drive the two high-pass mirrors 31 to rotate, the two supports 52 drive the two high-pass mirrors 31 to move vertically along the xoy axis direction, and the displacement assembly 53 drives the two high-pass mirrors 31 to move along the y axis direction.x axial direction, along z axial direction, changing the distance between the two high-pass mirrors 31.

[0099] In this embodiment, the displacement assembly 53 is a high-precision electrically controlled displacement table, which includes a sliding rail 532 and two sliders 531 arranged on the sliding rail 532. The two supports 52 are arranged on the two sliders 531. The position of the slider 531 is controlled by the high-pass controller 32 to make the two high-pass mirrors 31 horizontally move and change the distance between them.

[0100] The high-pass waveguide 35 is connected to the window mirror 34 at the output end of the sealed cavity 33. The connection end is a regular horn, and the horn surface has an angle less than 45° with the horizontal axis, which is used to collect the laser emitted by the sealed cavity 33 into the output module 4. The high-pass waveguide 35 is a metal waveguide with high reflectivity to the output wavelength laser.

[0101] The detection feedback system 36 includes a detector 361 and an analysis controller 362. The detector 361 is used to detect the output laser parameters, biological tissues and clinical data. The detected laser parameters include wavelength, power, transmittance, pulse width, line width, repetition frequency and spot size. The detected biological tissues and clinical data include the size of the ablated tissue area and the accompanying damage, and are transmitted to the analysis controller 362. The analysis controller 362 compares and analyzes the detected data and the set data, and then feeds back signals to control the transmission control module 2 and the high-pass controller 32, and is used to collect and store data to form a database. The information in the database includes target biological tissue type, target biological tissue size, operation time, laser working parameter and action time.

[0102] The output module 4 is connected to the other end of the high-pass waveguide 35 and includes a beam guiding assembly and an output end assembly connected in sequence. The laser emitted from the wide-spectrum high-pass transmitter is injected into the beam guiding assembly for shaping transmission, and then output by the output end assembly. In this embodiment, the beam guiding assembly 41 is an optical fiber for transmitting the required laser, and the size of the laser spot can be controlled. The output end assembly 42 is a puncture needle for applying the output required laser to the target biological tissue. The beam guiding assembly 41 and the output end assembly 42 are connected in sequence and optically coaxial, and the connection can be adjusted at any angle. Figure 10 The structure of the beam guiding assembly 41 and the output end assembly 42 in this embodiment is shown in the figure.

[0103] When the actual application end requires 795 nm laser for eye diagnosis, the use method of the multi-wavelength medical laser knife device of this embodiment is described with reference to Figure 8 The use method of the multi-wavelength medical laser knife device of this embodiment is described with reference to

[0104] According to the situation of the eye tissue to be acted on, the working mode of the output module 4 is determined as optical fiber transmission and puncture needle output.

[0105] In the analysis controller 362, set the laser operating parameters, target biological tissue type and clinical data, wherein the laser operating parameters include: wavelength 795 nm, power 1 W, continuous light output, spot diameter 1 mm, line width <1 nm; target biological tissue and clinical data include: eye diagnosis area size 3x3x5mm 3 , the allowable collateral damage <10 μm.

[0106] Start the transmission control module 2, and couple the multi-wavelength laser containing 795 nm output by the titanium sapphire laser 12 from the position close to the center of the wide spectrum high pass transmitter 2 into the sealed cavity 33. The high pass controller 32 adjusts the rotation, horizontal movement, vertical movement and distance between the two high pass mirrors 31, so that the multi-wavelength titanium sapphire laser containing 795 nm is coated with a reflective film of 750-850 nm in the incident area of the two high pass mirrors 31. The 795 nm laser is output after multiple reflections between the two high pass mirrors 31, and is emitted after passing through the high pass waveguide 35 and the output module 4, and acts on the target biological tissue. The detector 361 detects the output titanium sapphire laser parameters, and the detector 361 transmits the detection results to the analysis controller 362, and then the analysis controller 362 feeds back signals to the transmission control module 2 and the high pass controller 32 to control their operation;

[0107] Repeat the above steps to optimize the positions of the transmission control module 2 and the two high pass mirrors 31 until the data detected by the detector 361 is consistent with the set data, and the transmittance of the 795 nm laser is greater than 80%.

[0108] The output end module 4 continues to work, and the output 795 nm laser acts on the eye diagnosis; the analysis controller 362 collects and stores data, including: target biological tissue type, target biological tissue size, operation time, laser operating parameters, and action time, to form a database;

[0109] Finally, when the multi-wavelength medical laser knife of the application next acts on the eye diagnosis, the multi-wavelength medical laser knife can realize manual input work or automatic work according to the database data. Similarly, the multi-wavelength medical laser knife can also accurately control the output of 266 nm, 750-850 nm, 980-1300 nm, 2 μm, 6 μm and 10.6 μm lasers for removing different lesions.

[0110] Example 2

[0111] This embodiment proposes a multi-wavelength medical laser knife device, as shown in Figure 11 This embodiment is further improved on the basis of example 1, and the difference between this embodiment and example 1 is only that:

[0112] Two high-pass mirrors 34 in the wide-spectrum high-pass transmitter 3 are square silicon wafers with a size of 15*20*5 mm 3 placed in parallel; the two high-pass mirrors are also evenly divided into six coating areas, as shown in Figure 7 the coating diagram of the two high-pass mirrors 34 in this embodiment, which are coated with the same film system as in Embodiment 1, and the coating areas are all much larger than the size of the incident laser;

[0113] The adjustment module 5 adjusts the positions of the two high-pass mirrors by using a PZT piezoelectric ceramic driver; the difference from the high-precision electrically controlled translation stage is that the PZT piezoelectric ceramic sheet is arranged on the two supports 52, and the scanning voltage applied to the PZT piezoelectric ceramic sheet is changed by the high-pass controller 32, so that the two high-pass mirrors 31 move horizontally, and the distance between the two high-pass mirrors changes.

[0114] By controlling the distance between the two high-pass mirrors, the simultaneous emission of multiple wavelengths of laser can be met; for example, when the distance between the two high-pass mirrors simultaneously meets the high-pass output of 980 nm and 1064 nm lasers (T>80%), dual-wavelength mixed output is realized, meeting various application requirements.

[0115] In this embodiment, the beam guiding module 41 is selected as a light guide arm, and the output end module 42 is a laser pen knife, Figure 12 which is a structural diagram of the light guide arm of the beam guiding module 41 and the laser knife of the output end module 42 in this embodiment.

[0116] It should be understood that the above specific embodiments of the present application are only used for illustrative or explanatory purposes of the principles of the present application, and do not constitute a limitation on the present application. Therefore, any modification, equivalent replacement, improvement, etc. made without departing from the spirit and scope of the present application shall be included in the protection scope of the present application. In addition, the appended claims of the present application are intended to cover all variations and modifications falling within the scope and boundary of the appended claims, or the equivalent forms of such scope and boundary.

Claims

1. A multi-wavelength medical laser scalpel device, characterized by, The application relates to a multi-wavelength medical laser knife device. The device comprises a multi-wavelength laser source, a transmission control module, a wide-spectrum high-pass transmission device and an output module which are sequentially arranged along the light path direction. The multi-wavelength laser source comprises a plurality of lasers for providing laser beams of different wave bands, and the wavelength covers a spectrum range of 100 nm to 3 mm. The transmission control module is located at the laser exit end of the multi-wavelength laser source and is used for changing the transmission direction of the laser beams emitted by the multi-wavelength laser source and coupling the required laser beams into one end of the wide-spectrum high-pass transmission device. The wide-spectrum high-pass transmission device is used for selecting and controlling the laser parameters coupled into the device and transmitting the selected laser beams to the output module, wherein the controlled laser parameters include wavelength, line width, power and transmittance. The wide-spectrum high-pass transmission device comprises two oppositely arranged high-pass mirrors, a high-pass controller, a sealed cavity, two window mirrors, a high-pass waveguide and a detection feedback system. The sealed cavity provides a low-loss environment for the transmission of multi-wavelength laser beams and is used for reducing the laser loss caused by air absorption. The sealed cavity adopts a double-cavity structure, the region between the two cavities is vacuum, the inner cavity is filled with protective gas, and an internal and external pressure difference is formed. The sealed cavity has oppositely arranged input and output ends, the two window mirrors are arranged at the input and output ends and are used for coupling input and output multi-wavelength laser beams. The two high-pass mirrors are located in the sealed cavity, different wave bands of high-reflection films are coated on different regions of the inner surfaces of the high-pass mirrors close to the input end of the sealed cavity, corresponding wave bands of partial-reflection films are coated on corresponding regions of the inner surfaces of the high-pass mirrors close to the output end of the sealed cavity, and the positions of the two high-pass mirrors are controlled by the high-pass controller so as to select and control the multi-wavelength laser beams coupled into the sealed cavity. The high-pass waveguide is connected to the window mirror at the output end of the sealed cavity and is used for transmitting the laser beams transmitted through the sealed cavity. The detection feedback system is located at the output end of the output module and is used for detecting and analyzing the output laser parameters, biological tissues and clinical data and feeding back and controlling the high-pass controller and the transmission control module. The output module comprises a beam guiding assembly and an output end assembly which are sequentially and tightly connected.

2. The multi-wavelength medical laser knife device according to claim 1, wherein the two high-pass mirrors are made of any one of diamond and silicon wafer, so that the transmission spectrum range of the two high-pass mirrors covers the ultraviolet, visible light, infrared and terahertz wave bands.

3. The multi-wavelength medical laser knife device according to claim 1, wherein the two high-pass mirrors are arranged on an adjusting module, the adjusting module is located in the sealed cavity, and the adjusting module comprises two oppositely arranged adjusting tables, two supports and a displacement assembly. The two high-pass mirrors are arranged on the two adjusting tables, the two adjusting tables are fixed on the displacement assembly through the two supports, and rotation, horizontal movement, vertical movement of the two high-pass mirrors are driven by the adjusting module and the distance between the two high-pass mirrors is adjusted through the high-pass controller. The displacement assembly comprises a sliding rail and a sliding block arranged on the sliding rail, and the support is arranged on the sliding block; or a PZT piezoelectric ceramic sheet is arranged on the support, and the scanning voltage applied to the PZT piezoelectric ceramic sheet is changed through the high-pass controller to move the two high-pass mirrors.

4. The multi-wavelength medical laser knife device according to claim 1, wherein The two window mirrors are made of any one of diamond material or silicon wafer, so that the transmission spectrum range of the sealed cavity covers ultraviolet, visible light, infrared and terahertz wave bands.

5. The multi-wavelength medical laser knife device according to claim 1, wherein the connection end of the high-pass waveguide and the sealed cavity is regularly horn-shaped or shaped, for collecting the laser emitted through the sealed cavity into the output module. The high-pass waveguide is any one of a crystal with high transmittance for output laser, a metal waveguide with high reflectivity or a quartz waveguide coated with a high-reflectivity metal film.

6. The multi-wavelength medical laser scalpel device of claim 1, the probe feedback system comprising: A probe and an analysis controller; The probe is used for detecting output laser parameters, biological tissues and clinical data, the detected laser parameters include wavelength, power, transmittance, repetition frequency, pulse width, line width and spot size, the detected biological tissues and clinical data include the size of the ablated tissue region and the accompanying damage, and are transmitted to the analysis controller; The analysis controller compares and analyzes the detected data and the set data, and then feeds back a signal to control the transmission control module and the high-pass controller; And is used for collecting and storing data to form a database, the information of the database includes target biological tissue type, target biological tissue size, operation time, laser working parameter and action time.

7. The multi-wavelength medical laser scalpel device of claim 1, wherein, The beam guiding assembly is connected to the wide-spectrum high-pass transmitter, the beam guiding assembly is any one of a mechanical arm and an optical fiber, and the laser spot size can be controlled; The output end assembly is used for applying the output required laser to target biological tissues, and the output end assembly is any one of a laser pen knife, a puncture needle and a free-space output.

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