A kind of fruit acid composition and its preparation method and application

Abstract

The present invention discloses a fruit acid composition, a preparation method and an application thereof, belonging to the technical field of skin care products; the fruit acid composition provided by the present invention comprises a compound fruit acid, a compound soothing agent, betaine and D-panthenol; the compound fruit acid comprises lactic acid, glycolic acid, citric acid and lactobionic acid; the compound soothing agent comprises bisabolol and ginger root extract; by selecting appropriate fruit acids for compounding to form a compound fruit acid, and at the same time combining a compound soothing agent, betaine and D-panthenol, the obtained fruit acid composition can gently and non-irritatingly remove the cutin layer, whiten the skin and has excellent moisturizing effect on the skin. Further, when it is applied to the preparation of body wash, the obtained fruit acid body wash has excellent comprehensive performance.

Description

Technical Field

[0001] The invention belongs to the technical field of skin care products, and in particular relates to a fruit acid composition and a preparation method and application thereof. Background Art

[0002] Shower gel is a common daily necessity or skin care product, and its usage is large. With the improvement of people's living standards, people's demand for shower gel is also showing an upward trend. Fruit acid can effectively whiten, increase skin elasticity and moisturizing properties. Therefore, there are many products with added fruit acid in the existing shower gels, but the above shower gels either have the problem of insufficient amount of added fruit acid, resulting in an unobvious effect of the corresponding fruit acid, or have the problem of large amount of added fruit acid, resulting in greater irritation and more serious damage to the stratum corneum. Therefore, how to provide a shower gel with high fruit acid content and mildness has become a research hotspot. Summary of the invention

[0003] The purpose of the present invention is to overcome the deficiencies of the above-mentioned prior art and provide a fruit acid composition having good mildness, good moisturizing property, strong cleaning ability and capable of effectively whitening and moisturizing the skin, as well as a preparation method and application thereof.

[0004] To achieve the above object, in a first aspect of the present invention, the present invention provides a fruit acid composition, the fruit acid composition comprising a composite fruit acid, a composite soothing substance, betaine and D-panthenol;

[0005] The composite fruit acid includes lactic acid, glycolic acid, citric acid and lactobionic acid;

[0006] The soothing complex includes bisabolol and ginger root extract.

[0007] The fruit acid composition provided by the present invention is compounded by selecting appropriate fruit acids to form a composite fruit acid, and is combined with a composite soothing substance, betaine and D-panthenol. The obtained fruit acid composition can achieve good moisturizing properties without any irritation, and can also effectively whiten the skin.

[0008] Specifically, in the first aspect, the compound fruit acids selected in the present invention include lactic acid, glycolic acid, citric acid, and lactobionic acid. There is an excellent synergistic effect among the four fruit acids, which can achieve good cutin softening, pore dredging, skin cleansing, and skin whitening, while avoiding damage to the skin cutin layer, that is, achieving the effects of mild cleansing, moisturizing, and whitening. Among them, glycolic acid, also known as sugar cane acid and hydroxyacetic acid, has a high affinity for the skin. As the pioneer in the large family of fruit acids, it has the simplest chemical structure and the smallest molecular weight, so it is the most likely to penetrate into the skin surface to play a stronger role. When glycolic acid acts on the epidermis, it promotes the exfoliation of desmosomes between keratinocytes by activating steroid sulfatase and serine protease, reduces the adhesiveness between keratinocytes and the keratin accumulation, corrects abnormal follicular epithelial keratinization, accelerates the shedding of epidermal pigment cells, inhibits the formation of melanocytes, and promotes skin metabolism. When acting on the dermis, it can promote the release of mucopolysaccharides and hyaluronic acid, improve the hydration ability of cells, and thus enhance the softness and fineness of the skin. Although glycolic acid has obvious effects in improving skin texture, it also causes the most severe damage and irritation to the deep layer of the skin, and it is very easy to increase the number of sunburn cells in the skin, leading to the risk of skin dryness. Lactic acid is an acidic compound widely present in the human body and is also chemically called α-hydroxypropionic acid. Lactic acid has excellent moisturizing effects in skin care. It can regulate the water-oil balance of the skin, enhance the skin barrier function, prevent water loss, and thus keep the skin soft and smooth. In addition, lactic acid can also increase the natural moisturizing factor of the skin, improve the water retention ability of the skin, bring deep moisture to dry and water-deficient skin, and lactic acid also has a good cutin conditioning effect, which can accelerate the metabolism of cutin and promote the shedding of old cutin, so as to make the skin present a smoother and more delicate texture. Lactobionic acid, the third-generation fruit acid, has a relatively large molecular weight and a relatively slow penetration rate, so it has lower irritation and can effectively penetrate into the skin to play a better exfoliating effect. Citric acid is also a kind of fruit acid, also called citric acid, which can accelerate the renewal of skin cutin and make the skin more shiny.

[0009] In a second aspect, in addition to reducing irritation as much as possible while achieving excellent whitening and moisturizing effects of the composition by selecting appropriate components in the compound fruit acid, the present invention also synergistically reduces the irritation of the compound fruit acid by introducing appropriate parts by mass of a compound soothing agent, betaine, and D-panthenol. Moreover, the introduced compound soothing agent, betaine, and D-panthenol can further synergistically enhance the whitening and moisturizing effects of the product with the compound fruit acid, and at the same time can further enhance the cleaning ability of the product. Among them, the compound soothing agent includes bisabolol and ginger root extract, and the compound soothing agent can effectively help reduce the inflammatory response of the skin and relieve allergic symptoms. Betaine has anti-inflammatory and anti-allergic effects, can reduce the irritation of fruit acid, reduce the inflammatory response of the skin, soothe sensitive skin, reduce skin discomfort, and betaine also has a moisturizing effect, further achieving the effect of soothing skin discomfort. D-panthenol is a form of vitamin B5, has excellent moisturizing and nourishing abilities, can help the skin absorb and retain moisture, improve dry skin problems, and can also help repair damaged skin, reduce skin inflammation and redness, and promote the natural repair process of the skin, making the skin healthier and smoother.

[0010] In one embodiment, the fruit acid composition comprises the following components in parts by mass: 0.04 - 6 parts of compound fruit acid, 0.05 - 0.20 parts of compound soothing agent, 1 - 5 parts of betaine, and 0.1 - 2 parts of D-panthenol.

[0011] In one embodiment, the fruit acid composition comprises the following components in parts by mass: 2 - 4 parts of compound fruit acid, 0.08 - 0.15 parts of compound soothing agent, 2 - 4 parts of betaine, and 0.5 - 1 part of D-panthenol.

[0012] The present invention has found through research that the parts by mass of the components in the fruit acid composition will affect the performance of the composition. When further selecting the parts by mass of the components in the composition within the above ranges, the comprehensive effect of the obtained composition is more excellent.

[0013] In one embodiment, in the compound fruit acid, the mass ratio of lactic acid, glycolic acid, citric acid, and lactobionic acid is lactic acid: glycolic acid: citric acid: lactobionic acid = (1 - 4.5): (0.01 - 0.5): (0.01 - 0.5): (0.01 - 0.5).

[0014] In one embodiment, in the compound fruit acid, the mass ratio of lactic acid, glycolic acid, citric acid, and lactobionic acid is lactic acid: glycolic acid: citric acid: lactobionic acid = (2 - 3): 0.1: 0.1: 0.1.

[0015] Exemplarily, in the compound fruit acid, the mass ratio of lactic acid, glycolic acid, citric acid, and lactobionic acid can be any point value or any two-point range value between lactic acid: glycolic acid: citric acid: lactobionic acid = (2 - 3): 0.1: 0.1: 0.1, such as 2: 0.1: 0.1: 0.1, 2.1: 0.1: 0.1: 0.1, 2.2: 0.1: 0.1: 0.1, 2.3: 0.1: 0.1: 0.1, 2.4: 0.1: 0.1: 0.1, 2.5: 0.1: 0.1: 0.1, 2.6: 0.1: 0.1: 0.1, 2.7: 0.1: 0.1: 0.1, 2.8: 0.1: 0.1: 0.1, 2.9: 0.1: 0.1: 0.1, 3: 0.1: 0.1: 0.1, etc.

[0016] The research of the present invention finds that the addition amount of each fruit acid in the compound fruit acid and the mass ratio between the fruit acids will affect the comprehensive performance of the product. When further selecting the mass ratio of lactic acid, glycolic acid, citric acid, and lactobionic acid in the compound fruit acid as lactic acid: glycolic acid: citric acid: lactobionic acid = (1 - 4.5): (0.01 - 0.5): (0.01 - 0.5): (0.01 - 0.5), especially (2 - 3): 0.1: 0.1: 0.1, the obtained product has excellent whitening effect and less irritation, and the comprehensive performance of the body wash obtained when applied to the body wash is better.

[0017] In one embodiment, in the compound soothing agent, the mass ratio of bisabolol and ginger root extract is bisabolol: ginger root extract = 20: (0.01 - 1).

[0018] Exemplarily, in the compound soothing agent, the mass ratio of bisabolol and ginger root extract can be any point value or any two-point range value between bisabolol: ginger root extract = 20: (0.01 - 1), such as 20: 0.01, 20: 0.02, 20: 0.03, 20: 0.04, 20: 0.05, 20: 0.06, 20: 0.07, 20: 0.08, 20: 0.09, 20: 0.1, 20: 0.2, 20: 0.3, 20: 0.4, 20: 0.5, 20: 0.6, 20: 0.7, 20: 0.8, 20: 0.9, 20: 1, etc.

[0019] In one embodiment, in the compound soothing agent, the mass ratio of bisabolol and ginger root extract is bisabolol: ginger root extract = 20: (0.1 - 0.5).

[0020] The research of the present invention finds that the mass ratio of bisabolol and ginger root extract affects the soothing efficacy of the compound soothing agent and the synergistic effect with other components. When the mass ratio of bisabolol and ginger root extract is further selected to be 20:(0.01 - 1), especially 20:(0.1 - 0.5), the obtained product is milder and has better ability to improve the skin condition.

[0021] In one embodiment, the preparation method of the ginger root extract comprises the following steps: the ginger root extract is obtained by supercritical carbon dioxide extraction, and the supercritical carbon dioxide extraction comprises the following steps: after crushing the ginger root and putting it into the extraction tube, then putting the extraction tube into the extraction kettle, and then running the extraction program. After the extraction is completed, collect the extracted components to obtain the ginger root extract.

[0022] The research of the present invention finds that the preparation method of the ginger root extract also affects the comprehensive performance of the product. When the preparation method of the present invention is further selected, the content of the components with soothing efficacy and other related efficacies in the obtained ginger root extract is higher. Therefore, it can improve the mildness and comprehensive performance of the product as a whole, and can also help to achieve excellent cleaning effect of the product.

[0023] In one embodiment, the average particle size of the crushed ginger root is 10 - 100 mesh.

[0024] Exemplarily, the average particle size of the crushed ginger root can be any point value or any two - point range value between 10 - 100 mesh, such as 10 mesh, 20 mesh, 30 mesh, 40 mesh, 50 mesh, 60 mesh, 70 mesh, 80 mesh, 90 mesh, 100 mesh, etc.

[0025] In one embodiment, the extraction pressure is 20 - 45 MPa.

[0026] Exemplarily, the extraction pressure can be any point value or any two - point range value between 20 - 45 MPa, such as 20 MPa, 22 MPa, 24 MPa, 26 MPa, 28 MPa, 30 MPa, 32 MPa, 34 MPa, 36 MPa, 38 MPa, 40 MPa, 42 MPa, 45 MPa, etc.

[0027] In one embodiment, the extraction temperature is 30 - 60 °C.

[0028] Exemplarily, the extraction temperature can be any point value or any two - point range value between 30 - 60 °C, such as 30 °C, 35 °C, 40 °C, 45 °C, 50 °C, 55 °C, 60 °C, etc.

[0029] In one embodiment, the extraction time is 45 - 75 min.

[0030] Exemplarily, the extraction time can be any point value or any two-point range value between 45 - 75 min, such as 45 min, 50 min, 55 min, 60 min, 65 min, 70 min, 75 min, etc.

[0031] In one embodiment, the entrainer used in the extraction process is absolute ethanol, and the addition amount of the entrainer is 1 - 5%.

[0032] Exemplarily, the addition amount of the entrainer can be any point value or any two-point range value between 1 - 5%, such as 1%, 2%, 3%, 4%, 5%, etc.

[0033] In one embodiment, the density of carbon dioxide is 900 - 1000 kg / cm 3 .

[0034] Exemplarily, the density of the carbon dioxide can be any point value or any two-point range value between 900 - 1000 kg / cm 3 such as 900 kg / cm 3 , 910 kg / cm 3 , 920 kg / cm 3 , 930 kg / cm 3 , 940 kg / cm 3 , 950 kg / cm 3 , 960 kg / cm 3 , 970 kg / cm 3 , 980 kg / cm 3 , 990 kg / cm 3 , 1000 kg / cm 3 , etc.

[0035] In one embodiment, in the fruit acid composition, the mass percentage of the fruit acid is 42 - 48%.

[0036] Exemplarily, in the fruit acid composition, the mass percentage of the fruit acid can be any point value or any two-point range value between 42 - 48%, such as 42%, 43%, 44%, 45%, 46%, 47%, 48%, etc.

[0037] The research of the present invention finds that the mass percentage of the fruit acid in the fruit acid composition not only affects the irritation of the product, but also affects the comprehensive effect of the product on the skin. When further selecting the mass percentage of the fruit acid to be 42 - 48%, the comprehensive performance of the obtained product is more excellent.

[0038] In the second aspect of the present invention, the present invention provides a preparation method of a fruit acid composition, and the preparation method includes the following steps: mixing the components evenly to obtain the fruit acid composition.

[0039] In the third aspect of the present invention, the present invention provides the application of the fruit acid composition in the preparation of skin care products.

[0040] The fruit acid composition provided by the present invention has good cleaning ability, excellent and mild skin whitening and moisturizing effects, and can be applied to skin care products to achieve corresponding effects.

[0041] In the fourth aspect of the present invention, the present invention provides a fruit acid body wash, which comprises the following components in mass percentages: 1-15% fruit acid composition, 20-30% C14-16 olefin sulfonate, 2-25% surfactant, 1-5% humectant, 8-20% thickener, 0.01-0.2% chelating agent, 0.1-2% pH regulator, 0.2-1% preservative, and the balance water.

[0042] A fruit acid body wash provided by the present invention adds a fruit acid composition. Further, by selecting appropriate components and component addition amounts, and the components synergize with each other, it can achieve good effects of cleaning the skin, whitening the skin, and increasing the skin's moisture retention; and it can produce delicate and rich foam during use, with a good use experience. Specifically, on the basis of introducing the fruit acid composition, the C14-16 olefin sulfonate is further added to the fruit acid body wash of the present invention. The introduced C14-16 olefin sulfonate contains a double bond system, making the comprehensive performance of the body wash softer, and it also has good compatibility with other surfactants, which is beneficial to the production of rich and dense foam during the use of the prepared body wash, improving the user's evaluation of the use experience.

[0043] In one embodiment, the fruit acid body wash comprises the following components in mass percentages: 4-9% fruit acid composition, 24-28% C14-16 olefin sulfonate, 7-20% surfactant, 2-4% humectant, 10-15% thickener, 0.01-0.2% chelating agent, 0.1-2% pH regulator, 0.2-1% preservative, and the balance water.

[0044] The present invention has found through research that the mass content of the components in the fruit acid body wash will have an obvious impact on the performance of the product. When the mass content of the components is further selected within the above range, the obtained product has stronger cleaning ability, better overall skin condition after use, lower irritation, and the foam produced during the use of the obtained product is also more abundant and delicate.

[0045] In one embodiment, the mass ratio of betaine, C14-16 olefin sulfonate and surfactant is betaine: C14-16 olefin sulfonate: surfactant = 1: (6-14): (2-8).

[0046] Exemplarily, the mass ratio of the betaine, sodium C14-16 olefin sulfonate, and surfactant can be any point value or any two-point range value between betaine:sodium C14-16 olefin sulfonate:surfactant = 1:(6 - 14):(2 - 8), such as 1:6:2, 1:6:4, 1:6:6, 1:6:8, 1:8:2, 1:8:4, 1:8:6, 1:8:8, 1:10:2, 1:10:4, 1:10:6, 1:10:8, 1:12:2, 1:12:4, 1:12:6, 1:12:8, 1:14:2, 1:14:4, 1:14:6, 1:14:8, etc.

[0047] In one embodiment, the mass ratio of the betaine, sodium C14-16 olefin sulfonate, and surfactant is betaine:sodium C14-16 olefin sulfonate:surfactant = 1:(8 - 9):(4 - 6).

[0048] The research of the present invention finds that the mass ratio of betaine, sodium C14-16 olefin sulfonate, and surfactant has an impact on the mildness, cleaning ability, and skin-nourishing effect of the product, and also affects the foam characteristics of the product; specifically, the addition of betaine can not only reduce the irritation of fruit acid in the fruit acid composition, but also effectively reduce the irritation of the surfactant, has a good synergistic effect with sodium C14-16 olefin sulfonate, and increases the compatibility of the surfactant in the system; especially when the mass ratio of betaine, sodium C14-16 olefin sulfonate, and surfactant is further selected as 1:(6 - 14):(2 - 8), especially 1:(8 - 9):(4 - 6), the comprehensive performance of the obtained product is more excellent.

[0049] In one embodiment, the humectant includes sorbitol.

[0050] In one embodiment, the surfactant includes at least one of lauroyl sarcosinate surfactants and alkyl glycoside surfactants.

[0051] In one embodiment, the lauroyl sarcosinate surfactant includes sodium lauroyl sarcosinate, and the alkyl glycoside surfactant includes octyl / decyl glucoside, decyl glucoside, and coco glucoside.

[0052] The research of the present invention finds that when the above types of surfactants are selected, they not only have good compatibility with each other, so as to enhance the foaming effect and cleaning effect of the system, but also have excellent skin compatibility and reduce the irritation of the surfactant itself; and the above types of surfactants have excellent stability in the fruit acid composition system given in the present invention.

[0053] In one embodiment, the chelating agent includes at least one of disodium EDTA and sodium glutamate diethylenetriaminepentaacetate.

[0054] In one embodiment, the thickening agent includes at least one of cocoamidopropyl betaine and lauryl hydroxysulfobetaine.

[0055] The present invention has found through research that cocoamidopropyl betaine and lauryl hydroxysulfobetaine are zwitterionic surfactants, which have excellent stability under both acidic and alkaline conditions. Using at least one of cocoamidopropyl betaine and lauryl hydroxysulfobetaine as the thickening agent, it can cooperate well with other substances to achieve excellent foaming and thickening effects.

[0056] In one embodiment, the preservative includes at least one of phenoxyethanol and sodium benzoate.

[0057] In one embodiment, the pH regulator includes sodium hydroxide.

[0058] The present invention has found through research that by adding a fruit acid composition to the system and then using sodium hydroxide to adjust the pH value, specifically adjusting the pH to 5 - 6, this pH range is close to the pH range of human skin. It not only helps to protect the skin and reduce the irritation of the product to the skin, but also can effectively enhance the efficacy of the fruit acid, thereby overall improving the cleaning ability, skin whitening ability, and moisturizing ability of the product on the basis of maintaining the product's mildness and non-irritation.

[0059] In the fifth aspect of the present invention, the present invention provides a method for preparing the fruit acid body wash, and the preparation method includes the following steps: mixing the components evenly to obtain the fruit acid body wash.

[0060] In one embodiment, the method for preparing the fruit acid body wash includes the following steps:

[0061] (1) Mix and stir the materials in phase A and phase B, and heat up to disperse them evenly;

[0062] (2) After the first cooling, add the materials in phase C and disperse them evenly. Then, after the second cooling, add the materials in phase D and disperse them evenly. Subsequently, after the third cooling, add the materials in phase E, phase F, and phase G in sequence and disperse them evenly. Finally, after the fourth cooling, obtain the fruit acid body wash;

[0063] The materials in phase A include partial deionized water, a moisturizing agent, betaine, and a chelating agent;

[0064] The materials in phase B include sodium C14 - 16 olefin sulfonate and a surfactant;

[0065] The materials in phase C include a composite soothing agent;

[0066] The D-phase material includes a pH regulator and the remaining part of deionized water;

[0067] The E-phase material includes D-panthenol and a preservative;

[0068] The F-phase material includes fruit acid;

[0069] The G-phase material includes a thickening agent.

[0070] In one embodiment, in step (1), the temperature for stirring and heating is 80 - 85 °C.

[0071] In one embodiment, in step (2), the temperature after the first cooling is 70 - 75 °C, the temperature after the second cooling is 50 - 55 °C, the temperature after the third cooling is 40 - 45 °C, and the temperature after the fourth cooling is ≤ 38 °C.

[0072] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0073] In the present invention, a suitable fruit acid is selected for compounding to form a composite fruit acid, and at the same time, it is combined with a composite soothing agent, betaine and D-panthenol. The obtained fruit acid composition can gently and non-irritatingly remove the cutin layer, whiten the skin and have a moisturizing property. When it is applied to the preparation of a body wash at one step, by selecting suitable components such as surfactants, the obtained fruit acid body wash has excellent cleaning ability, and at the same time can effectively accelerate the shedding of melanocytes, reduce the melanin content in the skin epidermis and reduce the water loss of the skin, and the obtained fruit acid body wash has rich and delicate foam and is gentle and non-irritating when used. Description of the Drawings

[0074] Figure 1 It is a graph of the foam height at 30 s in the foam performance test of the product of Application Example 1;

[0075] Figure 2 It is a graph of the foam height at 5 min in the foam performance test of the product of Application Example 1;

[0076] Figure 3 It is a monitoring result graph in the cleaning ability test of the product of Application Example 1;

[0077] Figure 4 It is a monitoring result graph in the skin efficacy test of the product of Application Example 1;

[0078] Figure 5 It is a graph of the states of a single pimple D0 and D7 on the skin of Volunteer 1 in the skin efficacy test of the product of Application Example 1;

[0079] Figure 6 It is a graph of the states of a single pimple D0 and D7 on the skin of Volunteer 2 in the skin efficacy test of the product of Application Example 1. Detailed Embodiments

[0080] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0081] The reagents, methods and equipment used in the present invention, unless otherwise specified, are all conventional reagents, methods and equipment in the art; and unless otherwise specified, the raw materials used are from the same batch of raw materials.

[0082] The preparation method of ginger root extract 1 is as follows:

[0083] 1) Turn on the power, turn on the refrigerator and set the refrigeration temperature to 5°C, then open the CO2 cylinder to allow CO2 gas to enter the system, then turn on the control platform, and finally turn on the current limiting tube temperature controller and set the temperature of the current limiting tube to 30°C;

[0084] 2) Setting of supercritical extraction conditions: The extraction pressure (30 MPa), extraction temperature (45°C), entrainer dosage (3%) and extraction time (60 min) were set using the control platform. At the same time, the crushed ginger root powder (average particle size of 50 mesh) was loaded into the extraction tube and placed in the extraction kettle;

[0085] 3) Supercritical extraction process: When the refrigeration temperature is lower than 5°C, compress CO2 to the set pressure, wait for the temperature of the extraction kettle to stabilize, run the extraction program, and set the flow limiting tube temperature to 60°C;

[0086] 4) Completion of extraction: After the extraction process is completed, the CO2 in the extraction kettle is automatically emptied, the extraction kettle is opened, the extraction tube is removed, and the receiving bottle is removed at the same time to obtain the ginger root extract 1;

[0087] Ginger root extract 2: The only difference from ginger root extract 1 is that the extraction pressure is 50 MPa, the extraction temperature is 20 °C, and the extraction time is 40 min;

[0088] Ginger root extract 3: Grind ginger root into 200 mesh and add 8 times the amount of 50% ethanol aqueous solution, then heat and reflux for 3 hours, then filter, collect the filtrate and freeze-dry to obtain ginger root extract 3.

[0089] Examples 1-7

[0090] The embodiment of the present invention provides a fruit acid composition, and the weight parts of the fruit acid composition are shown in Table 1;

[0091] Table 1

[0092]

[0093] Example 8

[0094] The embodiment of the present invention provides a fruit acid composition, wherein the fruit acid composition is different from that of embodiment 1 in that ginger root extract 2 is used instead of ginger root extract 1.

[0095] Example 9

[0096] The embodiment of the present invention provides a fruit acid composition, wherein the fruit acid composition is different from that of embodiment 1 in that ginger root extract 3 is used instead of ginger root extract 1.

[0097] Comparative Example 1

[0098] The comparative example of the present invention provides a fruit acid composition, and the only difference between the fruit acid composition and Example 1 is that betaine is not added.

[0099] Comparative Example 2

[0100] The comparative example of the present invention provides a fruit acid composition, the only difference between the fruit acid composition and Example 1 is that D-panthenol is not added.

[0101] Comparative Example 3

[0102] The comparative example of the present invention provides a fruit acid composition, and the only difference between the fruit acid composition and Example 1 is that the ginger root extract is not added.

[0103] Comparative Example 4

[0104] The comparative example of the present invention provides a fruit acid composition, the only difference between the fruit acid composition and Example 1 is that citric acid is not added to the composite fruit acid, and the amount of lactic acid, glycolic acid and lactobionic acid is supplemented while keeping the mass ratio of lactic acid, glycolic acid and lactobionic acid and the total mass of the composite fruit acid unchanged.

[0105] Comparative Example 5

[0106] The comparative example of the present invention provides a fruit acid composition, the only difference between the fruit acid composition and Example 1 is that the composite fruit acid contains only lactic acid, and the lactic acid accounts for 3 parts.

[0107] Comparative Example 6

[0108] The comparative example of the present invention provides a fruit acid composition, and the only difference between the fruit acid composition and Example 1 is that trehalose is used instead of betaine.

[0109] Comparative Example 7

[0110] The comparative example of the present invention provides a fruit acid composition, wherein the fruit acid composition is different from Example 1 only in that D-panthenol is replaced by lubricant gum.

[0111] Comparative Example 8

[0112] The comparative example of the present invention provides a fruit acid composition, the only difference between the fruit acid composition and Example 1 is that the ginger root extract is replaced by garlic extract.

[0113] Comparative Example 9

[0114] The comparative example of the present invention provides a fruit acid shower gel, the only difference between the fruit acid shower gel and Example 1 is that malic acid is used instead of citric acid in the composite fruit acid.

[0115] Application Example 1-16 and Comparative Application Example 1-10

[0116] The application examples of the present invention and the comparative application examples provide a fruit acid shower gel, the components (mass percentage) of the fruit acid shower gel are shown in Table 2; wherein the fruit acid compositions in application examples 1-9 and comparative application examples 1-9 respectively use the fruit acid compositions prepared in embodiments 1-9 and comparative examples 1-9, for example, the fruit acid composition used in application example 6 is the fruit acid composition prepared in embodiment 6, and the same applies to the others; the fruit acid compositions used in application examples 10-16 and comparative application example 10 are the fruit acid compositions prepared in embodiment 1;

[0117] Table 2

[0118]

[0119] The preparation method of the fruit acid shower gel provided in Application Example 1 comprises the following steps:

[0120] (1) Mix and stir the materials of phase A and phase B and heat them to 80-85°C to disperse them evenly;

[0121] (2) After the first temperature is reduced to 70-75° C., the C phase material is added and dispersed evenly, and then the second temperature is reduced to 50-55° C., and the D phase material is added and dispersed evenly, and then the third temperature is reduced to 40-45° C., and the E phase material, the F phase material, and the G phase material are added in sequence and dispersed evenly, and finally the fourth temperature is reduced to 38° C. to obtain a fruit acid shower gel;

[0122] The phase A material includes part of deionized water (accounting for 50% of the total amount of deionized water), a moisturizer, betaine and a chelating agent;

[0123] The phase B material includes sodium C14-16 olefin sulfonate and a surfactant;

[0124] The phase C material includes a complex soothing substance;

[0125] The phase D material includes a pH regulator and the remaining portion of deionized water;

[0126] The E phase material includes D-panthenol and a preservative;

[0127] The phase F material includes complex fruit acid;

[0128] The G-phase material includes a thickening agent.

[0129] The preparation methods of the fruit acid body washes in Application Examples 2-16 and Comparative Application Examples 1-10 are the same as those in Application Example 1. If there are no relevant components, they can be omitted.

[0130] Application Example 17

[0131] The application example of the present invention provides a fruit acid body wash. The only difference between the fruit acid body wash and that in Application Example 1 is that cocamidopropyl betaine is replaced by coco-glucoside.

[0132] Application Example 18

[0133] The application example of the present invention provides a fruit acid body wash. The only difference between the fruit acid body wash and that in Application Example 1 is that lauryl hydroxysulfobetaine is replaced by cocamidopropyl betaine.

[0134] Comparative Application Example 11

[0135] The comparative application example of the present invention provides a fruit acid body wash. The only difference between the fruit acid body wash and that in Application Example 1 is that sodium C14-16 olefin sulfonate is not added, and its amount is made up with the amount of surfactant.

[0136] Comparative Application Example 12

[0137] The comparative application example of the present invention provides a fruit acid body wash. The only difference between the fruit acid body wash and that in Application Example 1 is that sodium C18 α-olefin sulfonate is replaced by sodium C14-16 olefin sulfonate.

[0138] Effect Example 1

[0139] The effect example of the present invention verifies the efficacy of the fruit acid compositions prepared in Examples 1-9 and Comparative Examples 1-9, specifically including the following aspects:

[0140] 1. Irritation test

[0141] The chicken embryo chorioallantoic membrane test was used for exploration. This operation was carried out in accordance with the industry standard of the People's Republic of China for entry-exit inspection and quarantine SN / T 2329-2009 "Chicken embryo chorioallantoic membrane test for eye irritation / corrosion of cosmetics"; specifically including the following steps:

[0142] (1) For eggs hatched to 9 days old, the eggshell was peeled from the air chamber end of the egg with forceps. After the inner membrane was infiltrated with 0.9% (mass fraction) physiological saline, the egg membrane was carefully peeled off from the edge to expose the chorioallantoic membrane;

[0143] (2) Pipette 0.3 mL of the fruit acid compositions of Examples 1-9 and Comparative Examples 1-9, dissolve them in PBS (pH 7.0), and dilute to a volume fraction of 1% for testing;

[0144] (3) After 3 minutes, observe the vascular changes in the chorioallantoic membrane. For transparent test substances, direct photography can be used for observation. For turbid or other test substances that affect observation, the test substances can be rinsed off with 0.9% saline and then photographed for observation. Use a magnifying glass lamp to observe the condition of the silicone rubber ring and the chorioallantoic membrane of the chicken embryo. Vascular congestion, vascular hemorrhage, and ghost vessels are the reaction conditions of irritation;

[0145] If the observation shows that at least one reaction of all 6 chicken embryos is scored above moderate (total score ≥ 12), the test should be repeated once. The score of each chicken embryo = the sum of the degrees of bleeding, coagulation, and vascular lysis observed in each chicken embryo; ES = the average value of the mathematical sum of the scores of 6 chicken embryos. Each sample is tested in parallel 6 times. The chicken embryo test standard (safety endpoint evaluation standard) is shown in Table 3;

[0146] Table 3

[0147] Chicken embryo score Irritation ES ≤ 12 No / mild irritation 12 < ES < 16 Moderate irritation ES ≥ 16 Strong irritation / corrosion

[0148] Statistically analyze the corresponding results, and the obtained results are shown in Table 4.

[0149] 2. Melanin synthesis inhibition test

[0150] Refer to TSHRH027-2019 for testing, and the obtained results are shown in Table 4.

[0151] Culture the mouse skin melanoma (B16-F10) culture in the experimental group and in the presence of 200 nM α-MSH (melanocyte-stimulating hormone) for 72 hours (37 °C, 5% carbon dioxide). Collect the used culture medium by centrifugation. Measure the absorbance at 405 nm with an enzyme-linked immunosorbent assay reader.

[0152] Melanin synthesis inhibition rate = (C - T / C - C0) * 100%

[0153] Wherein, T: absorbance of the test sample well;

[0154] C: the average value of 3 times of the absorbance of the negative control group;

[0155] C0: background absorbance of the melanin extract.

[0156] Table 4

[0157] Experimental group Chicken embryo score Melanin synthesis inhibition rate / % Experimental group Chicken embryo score Melanin synthesis inhibition rate / % Example 1 No irritation 43.1 Comparative example 1 Moderate irritation 22.9 Example 2 No irritation 35.8 Comparative example 2 Moderate irritation 20.2 Example 3 No irritation 35.2 Comparative example 3 Moderate irritation 24.8 Example 4 No irritation 31.7 Comparative example 4 No irritation 30.3 Example 5 No irritation 31.6 Comparative example 5 No irritation 29.5 Example 6 Mild irritation 32.1 Comparative example 6 Mild irritation 23.1 Example 7 Mild irritation 36.4 Comparative example 7 Mild irritation 20.6 Example 8 Mild irritation 27.3 Comparative example 8 Mild irritation 22.7 Example 9 Mild irritation 23.5 Comparative example 9 No irritation 26.8

[0158] As can be seen from Table 4, when the technical solution of the present invention is adopted, the obtained fruit acid composition has the characteristics of low irritation, and the obtained fruit acid composition also has a good effect of inhibiting melanin synthesis, and the melanin synthesis inhibition rate is above 23.5%; as can be seen from Examples 1-5, the mass parts of the components in the fruit acid composition will affect the performance of the product; as can be seen from Example 1 and Example 6, the mass ratio of each fruit acid in the compound fruit acid will also affect the performance of the fruit acid composition; as can be seen from Example 1 and Example 7, the mass ratio of bisabolol and ginger root extract in the compound soothing agent will also affect the performance of the product; as can be seen from Example 1 and Examples 8-9, when the preparation method of ginger root extract is changed, there are also differences in the performance of the obtained products; as can be seen from Example 1 and Comparative Examples 1-3, Comparative Examples 6-8, when betaine, D-panthenol or ginger root extract is not added or replaced by other ingredients, the irritation of the obtained fruit acid composition shows an increasing trend, especially when betaine, D-panthenol or ginger root extract is not added, and the melanin synthesis inhibition rate also shows a certain downward trend; as can be seen from Example 1 and Comparative Examples 4-5, Comparative Example 9, when the selection of the compound fruit acid is not within the scope of the present invention, the melanin synthesis inhibition rate of the obtained product decreases significantly.

[0159] Effect Example 2

[0160] This invention's Effect Example explores the efficacy of the fruit acid body wash prepared in Application Examples 1-18 and Comparative Application Examples 1-12, specifically including the following aspects:

[0161] 1. Irritation test

[0162] Use the patch test to verify the irritation of the fruit acid body wash prepared in Application Examples 1-18 and Comparative Application Examples 1-12. Specifically: Select 30 volunteers aged between 20 and 50 years old, number the patch test cell grids, and put the test samples into the corresponding numbered patch test cell grids respectively, with a dosage of 0.02 mL per grid; Stick the patch test device with the test substance on the arm skin of the subject with a low-sensitization tape, gently press it with the palm to make it evenly adhere to the skin, remove the patch test device after 24 hours, observe the skin condition of the wound area, and the identification criteria are shown in Table 5;

[0163] Table 5

[0164] Grade Symbol Identification standard 0 － Negative reaction: No stimulation, no erythema 1 ± Suspicious reaction: Mild erythema 2 + Weak positive reaction: Erythema 3 ++ Strong positive reaction: Erythema, papules, blisters 4 +++ Extremely strong positive reaction: Severe edema, large blisters

[0165] The test results are shown in Table 6;

[0166] Table 6

[0167]

[0168]

[0169] As can be seen from Table 6, when the fruit acid body wash prepared by the technical solution of the present invention is adopted, it has good mildness and almost no irritation; while when betaine, D-panthenol or ginger root extract is not added in Comparative Application Examples 1-3, the irritation of the obtained product is significantly increased; at the same time, when other substances are used to replace the substances in the present invention in Comparative Application Examples 6-7, the irritation of the obtained product is also significantly increased; in Comparative Application Example 10, due to the too high content of the fruit acid composition, its irritation also shows an increasing trend.

[0170] 2. Foam performance test

[0171] Since it is found through the irritation test that the irritation of Comparative Application Examples 1-3, Comparative Application Examples 6-7 and Comparative Application Example 10 is too strong and not suitable for actual use, therefore, their foam generating ability is not tested;

[0172] The application examples 1-18 and the comparative application examples 4-5, comparative application examples 8-9, and comparative application examples 11-12 are formulated into a 5% aqueous solution, added to a Kruss DFA100 foam analyzer, and foam is generated by stirring. According to the light transmittance of the sample, the average particle size, quantity, generated height and attenuation of the height of the foam are monitored by an optical sensor. The obtained images are analyzed with foam analysis software, and the average particle size distribution of the bubbles and the maximum foam volume during the test process are recorded; among them, the average particle size of the bubbles can reflect whether the foam is dense, and the maximum foam volume can reflect the richness of the foam; the obtained results are shown in Table 7;

[0173] Table 7

[0174]

[0175] As can be seen from Table 7, when the technical solution provided by the present invention is adopted, the obtained product has excellent foaming performance, generates a large amount of dense foam, the average particle size of the foam is below 280 microns, and the maximum foam volume is above 740 mL; among them, the foam height diagrams of the product obtained in Application Example 1 at 30 s and 5 min during the foam test are as Figure 1 - 2 shown, from Figure 1 - 2It can also be seen that the product prepared by the method provided by the present invention has uniform and delicate foam, excellent foaming ability, and slow foam attenuation, that is, good foam stability. It can be seen from Application Examples 1-9 and Application Examples 17-18 that the types of components and the mass ratio of components in the fruit acid composition will also have a certain impact on the foaming performance of the product. When the mass content of the components is further selected within the scope of the present invention, the foam generation ability of the obtained product is better. It can be seen from Application Example 1 and Application Examples 10-15 that the addition amount of the fruit acid composition and the content of other substances in the fruit acid lotion will also have an obvious impact on the foaming performance of the product. It can be seen from Application Example 1 and Application Example 16 that when the mass ratio of betaine, C14-16 olefin sulfonate, and surfactant in the fruit acid composition is further selected within the scope given by the present invention, the obtained product has better foaming ability.

[0176] It can be seen from Application Example 1 and Comparative Application Examples 11-12 that when C14-16 olefin sulfonate is not added or replaced with other substances, the foaming ability of the obtained fruit acid body wash decreases significantly, and the foam density also deteriorates significantly. Compared with Application Example 1, the average foam diameter of Comparative Application Examples 11-12 increased by 93.20-108.40%, and the maximum foam volume decreased by 15.18-21.52%.

[0177] 3. Cleaning ability test

[0178] Since it is found through the irritation test that Comparative Application Examples 1-3, Comparative Application Examples 6-7, and Comparative Application Example 10 are too irritating and not suitable for actual use. At the same time, since the foam performance of Comparative Application Examples 11-12 is too poor, resulting in an unsatisfactory use experience, only Application Examples 1-18, Comparative Application Examples 4-5, and Comparative Examples 8-9 are subjected to the cleaning ability test.

[0179] Select 230 subjects and divide them into 23 groups of test groups on average, with each test group containing 10 subjects. Apply the standard sebum containing carbon black on the inner arm of the subjects, and then clean it with the fruit acid body wash obtained from Application Examples 1-18, Comparative Application Examples 4-5, and Comparative Examples 8-9, as well as the commercially available body wash respectively. Measure the chromaticity ratio before and after cleaning, and the chromaticity before cleaning is kept consistent. The chromaticity ratios before and after cleaning are shown in Table 8, where the higher the chromaticity ratio, the better the cleaning ability.

[0180] ΔE1 = sqrt((L0 - L1)2 + (a0 - a1)2 + (b0 - b1)2)

[0181] ΔE2 = sqrt((L0 - L2)2 + (a0 - a2)2 + (b0 - b2)2)

[0182] ΔE1: Chromaticity difference of the skin after applying carbon black sebum;

[0183] ΔE2: Skin chromaticity difference immediately after cleaning;

[0184] L0: Basic skin brightness;

[0185] L1: Skin brightness after applying carbon black sebum;

[0186] L2: Skin brightness immediately after cleaning;

[0187] a0: Basic skin redness;

[0188] a1: Skin redness after applying carbon black sebum;

[0189] a2: Skin redness immediately after cleaning

[0190] b0: Basic skin yellowness;

[0191] b1: Skin yellowness after applying carbon black sebum;

[0192] B2: Skin yellowness immediately after cleaning; Cleaning rate = (ΔE1 - ΔE2) / ΔE1 Table 8

[0193]

[0194]

[0195]

[0196] As can be seen from Table 8, when the technical solution of the present invention is adopted, the obtained fruit acid body wash has excellent cleaning ability, and the cleaning rate is above 86.81%. Among them, the monitoring diagrams before and after cleaning of the product prepared by using Application Example 1 are as Figure 3 shown. As can be seen from Figure 3 , after cleaning with the product of the present invention, it can return to the state before cleaning, that is, the cleaning ability is excellent; as can be seen from Application Examples 1-9 and Application Examples 17-18, the type of components and the mass ratio of components in the fruit acid body wash will affect the cleaning ability of the product; as can be seen from Application Examples 1 and Application Examples 10-15, the content of the fruit acid composition and other substances in the fruit acid lotion will also affect the performance of the product; as can be seen from Application Examples 1 and Application Example 16, the mass ratio of betaine, C14 olefin sulfonate and surfactant in the fruit acid composition will also affect the performance of the product.

[0197] 4. Skin efficacy test

[0198] Since it was found through irritation tests that Comparative Application Examples 1-3, Comparative Application Examples 6-7, and Comparative Application Example 10 had excessive irritation and were not suitable for actual use, and at the same time, due to the poor foam performance of Comparative Application Examples 11-12, resulting in an unsatisfactory user experience, therefore, skin efficacy tests were only conducted on Application Examples 1-18 and Comparative Application Examples 4-5, and Comparative Examples 8-9;

[0199] According to the "Technical Specifications for Cosmetics Safety" (2015), 230 Asian adult testers aged 18-60 with relatively rough skin were selected, randomly divided into 23 groups of 10 people each. Under normal circumstances, the volunteers continuously used the fruit acid body wash all over the body for 28 days, and the data before and after use were calculated. The volunteers used the corresponding fruit acid body wash to clean every night and cleaned it according to the conventional cleaning method. They were visited on the 3rd, 7th, 14th, 21st, and 28th days, with 10 people in a group. On the day when the volunteers arrived, the test area was rinsed with clean water and no substances were applied, and they sat quietly in an air-conditioned room at a temperature of 21±1°C and a humidity of 50±10% for 20 minutes. An instrument was used to test the skin performance (front of the thigh);

[0200] The data includes the following aspects:

[0201] 1) The corresponding skin brightness L* was measured using a Glossymeter GL200, and the skin whitening effect was characterized by the skin brightness change rate. Among them, the brightness change rate = (brightness value before use - brightness value after use) / brightness value before use * 100%;

[0202] 2) The TEWL value was measured using a skin transdermal water loss probe TM Hex (Courage+Khazaka) to characterize the skin moisturizing effect. Among them, the TEWL value change rate = (TEWL value before use - TEWL value after use) / TEWL value before use * 100%;

[0203] At the same time, the volunteers were invited to score their evaluation during the use process. The score was on a 10-point scale, with 10 points representing extremely satisfied and 0 points representing not satisfied at all, and the total score was recorded;

[0204] The results obtained are shown in Table 9;

[0205] Table 9

[0206]

[0207]

[0208] As can be seen from Table 9, when the technical solution of the present invention is adopted, the obtained product has excellent moisturizing and whitening effects, and the overall satisfaction score is relatively high; specifically, the absolute value of the brightness change rate is above 23.19%, and the change rate of the TEWL value is above 24.48%; moreover, the usage effect score of the prepared fruit acid body wash is relatively high, above 80.00 points; among them, the back change diagram of one of the volunteers on D0 and D28 days using the product obtained in Application Example 1 is as Figure 4 shown. As can be seen from Figure 4 , the method provided by the present invention can effectively brighten the skin, moisturize the skin, soothe the skin, and thus relieve acne problems; in addition, single acne on any two volunteers is recorded respectively, as Figure 5 - 6 shown. As can be seen from Figure 5 - 6 , it can be clearly seen that after using the product provided by the present invention, it can effectively moisturize the skin, soothe the skin, and relieve acne;

[0209] As can be seen from Application Examples 1-5, when the mass parts of the components in the fruit acid composition are further selected within the preferred range, the comprehensive performance of the obtained product is better; as can be seen from Application Examples 1 and 6-7, the mass ratio of the components in the compound fruit acid and the compound soothing agent will also affect the performance of the product; as can be seen from Application Examples 1 and Application Examples 8-9, the preparation method of the ginger root extract will also affect the comprehensive performance of the product; as can be seen from Application Examples 1 and Application Examples 10-15, the mass percentage of the components in the fruit acid body wash will affect the comprehensive effect of the product; as can be seen from Application Examples 1 and Application Example 16, the mass ratio of betaine, C14-16 olefin sulfonate and surfactant in the fruit acid composition will also affect the comprehensive performance of the product;

[0210] As can be seen from Application Example 1 and Comparative Application Examples 4-5 and Comparative Application Example 9, when the type of fruit acid in the compound fruit acid is changed, the actual application effect of the obtained product is significantly worse; as can be seen from Application Example 1 and Comparative Application Example 8, when other ingredients are used to replace the ginger root extract, the actual application effect of the obtained product is also significantly worse.

[0211] Finally, it should be noted that the above embodiments are used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A fruit acid body wash, characterized in that, The fruit acid body wash comprises the following components in mass percentages: 1-15% fruit acid composition, 20-30% C14-16 olefin sulfonate, 2-25% surfactant, 1-5% humectant, 8-20% thickener, 0.01-0.2% chelating agent, 0.1-2% pH regulator, 0.2-1% preservative, and the balance being water; The fruit acid composition comprises the following components in parts by mass: 2-4 parts of compound fruit acid, 0.08-0.15 parts of compound soothing agent, 2-4 parts of betaine, and 0.5-1 part of D-panthenol; The compound fruit acid is composed of lactic acid, glycolic acid, citric acid, and lactobionic acid; The compound soothing agent includes bisabolol and ginger root extract; The ginger root extract is obtained by supercritical carbon dioxide extraction, and the supercritical carbon dioxide extraction comprises the following steps: Crush the ginger root and put it into the extraction tube, then put the extraction tube into the extraction kettle, then run the extraction program. After the extraction is completed, collect the extracted components to obtain the ginger root extract. The extraction pressure is 20-45 MPa, the extraction temperature is 30-60 °C, and the extraction time is 45-75 min; In the compound fruit acid, the mass ratio of lactic acid, glycolic acid, citric acid, and lactobionic acid is lactic acid: glycolic acid: citric acid: lactobionic acid = (2-3): 0.1:0.1:0.1； In the compound soothing agent, the mass ratio of bisabolol to ginger root extract is bisabolol: ginger root extract = 20: (0.1-0.5); The mass ratio of betaine, C14-16 olefin sulfonate, and surfactant is betaine: C14-16 olefin sulfonate: surfactant = 1: (8-9): (4-6).

2. The fruit acid body wash according to claim 1, wherein Meet any one of the following: a. The average particle size of the crushed ginger root is 10-100 mesh; b. The entrainer used in the extraction program is anhydrous ethanol, and the addition amount of the entrainer is 1-5%; c. The density of carbon dioxide is 900 - 1000 kg / cm 3 .

3. The fruit acid body wash according to claim 1, characterized in that, In the fruit acid composition, the mass percentage of fruit acid is 42-48%.

4. The fruit acid body wash according to claim 1, wherein The preparation method of the fruit acid composition comprises the following steps: Mix the components evenly to obtain the fruit acid composition.

5. The fruit acid body wash according to any one of claims 1-4, characterized in that Meet at least one of the following: a. The humectant includes sorbitol; b. The surfactant includes at least one of lauroyl sarcosinate surfactants and alkyl glycoside surfactants; c. The chelating agent includes at least one of disodium EDTA and diethylenetriaminepentaacetic acid disodium glutamate; d. The thickener includes at least one of coconut oil amide propyl betaine and lauryl hydroxy sulfobetaine; e. The preservative includes at least one of phenoxyethanol and sodium benzoate; f. The pH regulator includes sodium hydroxide.

6. The preparation method of the fruit acid body wash according to any one of claims 1-4, characterized in that, The preparation method comprises the following steps: Mix the components evenly to obtain the fruit acid body wash.

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