A composition with auxiliary blood pressure lowering effect and its preparation method and application

Abstract

The present invention provides a composition with auxiliary blood pressure lowering effect and its preparation method and application. The present invention has a composition with auxiliary blood pressure lowering effect, including the following raw materials in parts by weight: 8-12 parts of green tea, 5-10 parts of gynostemma pentaphyllum, 4-6 parts of kudingcha, 5-10 parts of lily, 4-6 parts of sanqi leaves, 8-12 parts of cassia seeds, 3-8 parts of American ginseng, 1-3 parts of sophora japonica, 3-5 parts of red ramie extract, 8-10 parts of chasteberry extract. The present invention also provides a preparation method of a composition with auxiliary blood pressure lowering effect, comprising the following steps: taking green tea, gynostemma pentaphyllum, American ginseng, cassia seed, adding purified water and strain A to ferment to obtain fermented product A; taking kudingcha, lily, sanqi leaves, sophora japonica, adding purified water and strain B to ferment to obtain fermented product B; fermented product A, fermented product B and red ramie extract, chasteberry extract are mixed evenly and sterilized. The present composition has obvious auxiliary blood pressure lowering effect and can be preferably applied to the preparation of auxiliary blood pressure lowering functional food.

Description

Technical Field

[0001] The present invention relates to the field of deep processing of natural products, and in particular to a composition with auxiliary blood pressure lowering effect, and a preparation method and application thereof. Background Art

[0002] Hypertension refers to the higher-than-normal pressure exerted on the blood vessel walls by blood flowing through them. It is a very common cardiovascular disease and a significant risk factor for diseases such as stroke, coronary heart disease, and heart failure. Hypertension can be diagnosed when blood pressure is higher than normal on three separate days, without the use of antihypertensive medications, i.e., systolic blood pressure ≥140 mmHg and / or diastolic blood pressure ≥90 mmHg. Essential hypertension is high blood pressure with unknown etiology, accounting for over 95% of hypertensive patients, and most patients have a family history of the disease.

[0003] Currently, hypertension cannot be cured. Regular medication can alleviate or eliminate symptoms and maintain a normal quality of life. Commonly used medications include calcium channel blockers, angiotensin-converting enzyme (ACEI) inhibitors, angiotensin II receptor blockers, central alpha agonists, and beta blockers. Long-term use can cause side effects in some patients. Diet plays an important role in restoring and maintaining blood pressure in hypertensive patients. The development of functional foods that can assist in lowering blood pressure is of great value. Summary of the Invention

[0004] In view of this, the present invention proposes a composition with auxiliary blood pressure lowering effect and a preparation method thereof, which has obvious auxiliary blood pressure lowering effect and high safety.

[0005] The technical solution of the present invention is achieved as follows: a composition with auxiliary blood pressure lowering effect comprises the following raw materials in parts by weight: 8-12 parts of green tea, 5-10 parts of Gynostemma pentaphyllum, 4-6 parts of Kudingcha tea, 5-10 parts of lily, 4-6 parts of Panax notoginseng leaves, 8-12 parts of Cassia seeds, 3-8 parts of American ginseng, 1-3 parts of Sophora japonica flowers, 3-5 parts of red ramie extract, and 8-10 parts of Chaenomeles sinensis extract.

[0006] A preferred technical solution, the composition with auxiliary blood pressure lowering effect includes the following raw materials in parts by weight: 10 parts of green tea, 8 parts of Gynostemma pentaphyllum, 5 parts of Kudingcha, 8 parts of lily, 5 parts of Panax notoginseng leaves, 10 parts of Cassia seeds, 5 parts of American ginseng, 2 parts of Sophora japonica flowers, 4 parts of red ramie extract, and 9 parts of Chaste tree fruit extract.

[0007] According to a preferred technical solution, the red ramie extract is a red ramie water extract.

[0008] According to a preferred technical solution, the chasteberry extract is a chasteberry ethanol extract.

[0009] A preferred technical solution, the preparation method of the red ramie extract includes the following steps: taking red ramie medicinal materials, crushing them, adding water according to a material-liquid ratio of 1:8-12 kg / L, boiling and extracting for 2-4 hours, repeating the extraction 2-3 times, combining the extracts, and concentrating under reduced pressure to obtain an extract; eluting the extract using a D101 macroporous adsorption resin with a 40%-60% v / v ethanol solution as the elution solvent, collecting the eluate, concentrating under reduced pressure, and drying to obtain the red ramie extract.

[0010] The preferred technical solution is that the preparation method of the chasteberry extract includes the following steps: taking chasteberry fruits, beating them into pulp, placing them in a 65%-75% v / v ethanol solution, first ultrasonically treating them at room temperature for 8-12 minutes, then extracting them at 45-50°C for 1-2 hours, filtering, collecting the extract, concentrating it under reduced pressure, and drying it to obtain the chasteberry extract.

[0011] The present invention also provides a preparation method for a composition with auxiliary blood pressure lowering effect, comprising the following steps: taking green tea, gynostemma pentaphyllum, American ginseng, and cassia seed, adding water at a material-liquid ratio of 1:2-3 (kg / L), and then mixing and evenly fermenting with strain A to obtain fermentation product A; taking kudingcha tea, lily, Panax notoginseng leaves, and sophora japonica flower, adding water at a material-liquid ratio of 1:2-3 (kg / L), and then mixing and evenly fermenting with strain B to obtain fermentation product B; and uniformly mixing fermentation product A and fermentation product B with red ramie extract and chasteberry fruit extract, and sterilizing.

[0012] According to a preferred technical solution, the bacterial strain A is composed of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5-6:0.8-1.2; and the bacterial strain B is composed of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 0.8-1.2:2-4.

[0013] According to a preferred technical solution, the inoculation amount of strain A is 2%-3% of the weight of the material, and the inoculation amount of strain B is 1%-2% of the weight of the material.

[0014] The preferred technical solution is that the fermentation temperature is 30-40°C and the fermentation time is 2-3 days.

[0015] The composition of the present invention is used in preparing functional food for assisting in lowering blood pressure.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] (1) The formula composition of the present invention has obvious auxiliary blood pressure lowering effect and can be well used in the preparation of functional foods for auxiliary blood pressure lowering.

[0018] (2) The present invention uses green tea, Gynostemma pentaphyllum, Kudingcha tea, lily, Panax notoginseng leaf, Cassia seed, American ginseng, and Sophora japonica flower as raw materials, and combines them with red ramie water extract and Vitex schizophreniae ethanol extract to optimize the formula ratio, effectively improve the auxiliary blood pressure lowering effect, avoid the harm of high blood pressure, and help reduce high blood pressure levels and stabilize them.

[0019] (3) The present invention uses a composite bacterial strain composed of Lactobacillus acidophilus and Lactobacillus brevis, and a composite bacterial strain composed of Saccharomyces cerevisiae and Lactobacillus plantarum to ferment in steps, effectively increasing the content level of the active ingredient in the product that assists in lowering blood pressure.

[0020] (4) The process of the present invention uses natural products as the main raw materials, and the products prepared are not only highly safe but also easy to absorb. DETAILED DESCRIPTION

[0021] In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

[0022] Unless otherwise specified, the experimental methods used in the examples of the present invention are all conventional methods.

[0023] Unless otherwise specified, the materials, reagents, etc. used in the examples of the present invention can be obtained from commercial sources.

[0024] The Lactobacillus acidophilus, Lactobacillus brevis, Saccharomyces cerevisiae, and Lactobacillus plantarum used in the present invention are all commercially available bacterial powders, and the concentration of live bacteria is 1.0×10 11 CFU / g.

[0025] Preparation Example

[0026] Preparation of red hemp extract: Take red hemp medicinal material, crush it, add water at a material-liquid ratio of 1:10 (kg / L), boil it until boiling and extract for 3 hours, repeat the extraction twice, combine the extracts, and concentrate under reduced pressure to obtain an extract; elute the extract using D101 macroporous adsorption resin, using 50% v / v ethanol solution as the elution solvent, collect the eluate, concentrate under reduced pressure, and dry it to obtain the red hemp extract.

[0027] Preparation of Vitex schizophreniae extract: Take Vitex schizophreniae fruit, beat it into pulp, place it in 70% v / v ethanol solution, first ultrasonically treat it at room temperature for 10 minutes, then extract it at 48℃±2℃ for 1 hour, filter it, collect the extract, concentrate it under reduced pressure, and dry it to obtain Vitex schizophreniae extract.

[0028] Example 1 - Auxiliary blood pressure lowering product

[0029] 1. Recipe

[0030] Table 1 Recipe

[0031] Serial number raw material Dosage (g) 1 green tea 10 2 Gynostemma pentaphyllum 8 3 Kudingcha 5 4 lily 8 5 Panax notoginseng leaves 5 6 Cassia seeds 10 7 American ginseng 5 8 Sophora japonica 2 9 Red Hemp Extract 4 10 Chasteberry Extract 9

[0032] 2. Process

[0033] According to the above formula table, green tea, gynostemma pentaphyllum, American ginseng, and cassia seed are taken respectively, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain A (strain A consists of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5:1), and fermented at a temperature of 30-40°C for 3d, with an inoculum amount of strain A of 2.5% by weight of the material to obtain fermentation A; Kudingcha, lily, Panax notoginseng leaves, and Sophora japonica flowers are taken, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain B (strain B consists of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 1:3), and fermented at a temperature of 30-40°C for 2d, with an inoculum amount of strain B of 1.5% by weight of the material to obtain fermentation B; fermentation A and fermentation B are mixed with the red ramie extract and the chasteberry extract of the preparation example, mixed evenly, dried, crushed through a 100-mesh sieve, sterilized, and packaged to obtain an auxiliary blood pressure lowering solid product (powder).

[0034] Example 2-Assisted blood pressure lowering product

[0035] 1. Recipe

[0036] Table 2 Recipe

[0037] Serial number raw material Dosage (g) 1 green tea 8 2 Gynostemma pentaphyllum 10 3 Kudingcha 4 4 lily 5 5 Panax notoginseng leaves 4 6 Cassia seeds 12 7 American ginseng 8 8 Sophora japonica 2 9 Red Hemp Extract 5 10 Chasteberry Extract 8

[0038] 2. Process

[0039] According to the above formula table, green tea, gynostemma pentaphyllum, American ginseng, and cassia seed are taken respectively, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain A (strain A consists of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5:1), and fermented at a temperature of 30-40°C for 3d, with an inoculum amount of strain A of 2.5% by weight of the material to obtain fermentation A; Kudingcha, lily, Panax notoginseng leaves, and Sophora japonica flowers are taken, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain B (strain B consists of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 1:3), and fermented at a temperature of 30-40°C for 2d, with an inoculum amount of strain B of 1.5% by weight of the material to obtain fermentation B; fermentation A and fermentation B are mixed with the red ramie extract and the chasteberry extract of the preparation example, mixed evenly, dried, crushed through a 100-mesh sieve, sterilized, and packaged to obtain an auxiliary blood pressure lowering solid product (powder).

[0040] Example 3-Assisted blood pressure lowering product

[0041] 1. Recipe

[0042] Table 3 Recipe

[0043] Serial number raw material Dosage (g) 1 green tea 12 2 Gynostemma pentaphyllum 5 3 Kudingcha 6 4 lily 10 5 Panax notoginseng leaves 6 6 Cassia seeds 8 7 American ginseng 3 8 Sophora japonica 3 9 Red Hemp Extract 3 10 Chasteberry Extract 10

[0044] 2. Process

[0045] According to the above formula table, green tea, gynostemma pentaphyllum, American ginseng, and cassia seed are taken respectively, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain A (strain A consists of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5:1), and fermented at a temperature of 30-40°C for 3d, with an inoculum amount of strain A of 3.0% by weight of the material to obtain fermentation A; Kudingcha, lily, Panax notoginseng leaves, and Sophora japonica flowers are taken, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain B (strain B consists of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 1:3), and fermented at a temperature of 30-40°C for 2d, with an inoculum amount of strain B of 2.0% by weight of the material to obtain fermentation B; fermentation A and fermentation B are mixed with the red ramie extract and the chasteberry extract of the preparation example, mixed evenly, dried, crushed through a 100-mesh sieve, sterilized, and packaged to obtain an auxiliary blood pressure lowering solid product (powder).

[0046] Comparative Example 1

[0047] The main difference from Example 1 is the dosage of the formula raw materials.

[0048] 1. Recipe

[0049] Table 4 Recipe

[0050] Serial number raw material Dosage (g) 1 green tea 10 2 Gynostemma pentaphyllum 10 3 Kudingcha 10 4 lily 10 5 Panax notoginseng leaves 10 6 Cassia seeds 10 7 American ginseng 10 8 Sophora japonica 10 9 Red Hemp Extract 10 10 Chasteberry Extract 10

[0051] 2. Process

[0052] According to the above formula table, green tea, gynostemma pentaphyllum, American ginseng, and cassia seed are taken respectively, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain A (strain A consists of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5:1), and fermented at a temperature of 30-40°C for 3d, with an inoculum amount of strain A of 2.5% by weight of the material to obtain fermentation A; Kudingcha, lily, Panax notoginseng leaves, and Sophora japonica flowers are taken, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain B (strain B consists of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 1:3), and fermented at a temperature of 30-40°C for 2d, with an inoculum amount of strain B of 1.5% by weight of the material to obtain fermentation B; fermentation A and fermentation B are mixed with the red ramie extract and the chasteberry extract of the preparation example, mixed evenly, dried, crushed through a 100-mesh sieve, sterilized, and packaged to obtain an auxiliary blood pressure lowering solid product (powder).

[0053] Comparative Example 2

[0054] The main difference from Example 1 is that the added amounts of the formula raw materials, red ramie extract and chasteberry extract, are different from those in Example 1.

[0055] 1. Recipe

[0056] Table 5 Recipe

[0057] Serial number raw material Dosage (g) 1 green tea 10 2 Gynostemma pentaphyllum 8 3 Kudingcha 5 4 lily 8 5 Panax notoginseng leaves 5 6 Cassia seeds 10 7 American ginseng 5 8 Sophora japonica 2 9 Red Hemp Extract 8 10 Chasteberry Extract 5

[0058] 2. Process

[0059] According to the above formula table, green tea, gynostemma pentaphyllum, American ginseng, and cassia seed are taken respectively, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain A (strain A consists of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5:1), and fermented at a temperature of 30-40°C for 3d, with an inoculum amount of strain A of 2.5% by weight of the material to obtain fermentation A; Kudingcha, lily, Panax notoginseng leaves, and Sophora japonica flowers are taken, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain B (strain B consists of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 1:3), and fermented at a temperature of 30-40°C for 2d, with an inoculum amount of strain B of 1.5% by weight of the material to obtain fermentation B; fermentation A and fermentation B are mixed with the red ramie extract and the chasteberry extract of the preparation example, mixed evenly, dried, crushed through a 100-mesh sieve, sterilized, and packaged to obtain an auxiliary blood pressure lowering solid product (powder).

[0060] Comparative Example 3

[0061] The main difference from Example 1 is that the formula does not contain red ramie extract and vitex aconitifolia extract.

[0062] 1. Recipe

[0063] Table 6 Recipe

[0064] Serial number raw material Dosage (g) 1 green tea 10 2 Gynostemma pentaphyllum 8 3 Kudingcha 5 4 lily 8 5 Panax notoginseng leaves 5 6 Cassia seeds 10 7 American ginseng 5 8 Sophora japonica 2 9 Red Hemp Extract 0 10 Chasteberry Extract 0

[0065] 2. Process

[0066] According to the above formula table, green tea, gynostemma pentaphyllum, American ginseng, and cassia seed are taken respectively, purified water is added according to a material-liquid ratio of 1:2.5 (kg / L), and the mixture is mixed with strain A (strain A consists of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5:1), and fermented at a temperature of 30-40°C for 3 days, with an inoculation amount of strain A of 2.5% of the material weight to obtain fermentation A; Kudingcha, lily, Panax notoginseng leaves, and Sophora japonica flowers are taken, purified water is added according to a material-liquid ratio of 1:2.5 (kg / L), and the mixture is mixed with strain B (strain B consists of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 1:3), and fermented at a temperature of 30-40°C for 2 days, with an inoculation amount of strain B of 1.5% of the material weight to obtain fermentation B; fermentation A and fermentation B are mixed, mixed evenly, dried, crushed through a 100-mesh sieve, sterilized, and packaged to obtain a solid product (powder) for assisting in lowering blood pressure.

[0067] Comparative Example 4

[0068] The main difference from Example 1 is that the bacterial species in the preparation process are different, and only a single bacterial species is used for fermentation.

[0069] 1. Recipe

[0070] The formula is consistent with the formula table 1 of embodiment 1.

[0071] 2. Process

[0072] According to Formula Table 1, green tea, Gynostemma pentaphyllum, American ginseng, and Cassia seed are taken respectively, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain A (strain A is Lactobacillus acidophilus), and fermented at a temperature of 30-40°C for 3 days, with an inoculation amount of strain A of 2.5% by weight of the material to obtain fermentation A; Kudingcha, lily, Panax notoginseng leaves, and Sophora japonica flowers are taken, purified water is added according to a material-liquid ratio of kg / L of 1:2.5, and the mixture is mixed with strain B (strain B is Saccharomyces cerevisiae), and fermented at a temperature of 30-40°C for 2 days, with an inoculation amount of strain B of 1.5% by weight of the material to obtain fermentation B; fermentation A and fermentation B are mixed with the red ramie extract and the chasteberry extract of the preparation example, mixed evenly, dried, crushed through a 100-mesh sieve, sterilized, and packaged to obtain an auxiliary blood pressure lowering solid product (powder).

[0073] Test example

[0074] Clean-grade primary hypertensive rats (SHR), male, 11 weeks old, weighing 190-210g, were selected. The SHR rats were randomly divided into study groups 1-7, blank group, and positive control group, with 10 rats in each group. Study groups 1-7: were given the auxiliary blood pressure lowering products of Examples 1-3 and Comparative Examples 1-4, respectively, at a dose of 5 mg / kg; positive control group: captopril, at a dose of 2.5 mg / kg; blank group: were given an equal volume of purified water; gavage. Once a day, for 4 consecutive weeks. After 4 weeks, the blood pressure of SHR rats was measured using the rat tail artery systolic pressure method, and the measurement was repeated 3 times to take the average value. At the same time, the heart rate of SHR rats was recorded before and after the experiment. The results are shown in Tables 7-8.

[0075] Table 7 Effects on blood pressure of SHR rats

[0076]

[0077] As shown in Table 7, after four weeks, the blood pressure of the SHR rats in the blank group continued to increase. After four weeks of administration of the auxiliary blood pressure-lowering products and captopril in Examples 1-3 and Comparative Examples 1-4, the blood pressure of the SHR rats decreased to varying degrees. Compared with the blank group, the positive control group and the groups of Examples 1-3 all showed significant decreases (P < 0.05), remaining at a relatively low level. Among them, the products of Examples 1-3 showed a significant auxiliary blood pressure-lowering effect.

[0078] Table 8 Effects on the heart rate of SHR rats

[0079]

[0080] As shown in Table 8, the heart rate of SHR rats did not change significantly before and after the experiment (P>0.05), indicating that the auxiliary blood pressure lowering product prepared by the present invention had no significant effect on the heart rate of rats (P>0.05), and the mice grew well.

[0081] In summary, the products of Examples 1-3 of the present invention have obvious auxiliary blood pressure lowering effects and are highly safe, and can be well applied to the preparation of functional foods for auxiliary blood pressure lowering.

[0082] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A composition having an auxiliary blood pressure lowering effect, characterized in that: The invention is prepared from the following raw materials in parts by weight: 8-12 parts of green tea, 5-10 parts of gynostemma pentaphyllum, 4-6 parts of kudingcha tea, 5-10 parts of lily, 4-6 parts of notoginseng leaves, 8-12 parts of cassia seeds, 3-8 parts of American ginseng, 1-3 parts of sophora japonica flower, 3-5 parts of red ramie extract, and 8-10 parts of chasteberry fruit extract; The preparation method of the red ramie extract comprises the following steps: taking red ramie medicinal material, crushing it, adding water at a material-liquid ratio of 1:8-12 (kg / L), boiling it and extracting it for 2-4 hours, repeating the extraction 2-3 times, combining the extracts, and concentrating under reduced pressure to obtain an extract; eluting the extract with a D101 macroporous adsorption resin using a 40%-60% v / v ethanol solution as an elution solvent, collecting the eluate, concentrating it under reduced pressure, and drying it to obtain the red ramie extract; The preparation method of the chasteberry fruit extract comprises the following steps: taking chasteberry fruit, beating the pulp, placing the pulp in a 65%-75% v / v ethanol solution, first ultrasonically treating the pulp at room temperature for 8-12 minutes, then extracting the pulp at 45-50° C. for 1-2 hours, filtering the pulp, collecting the extract, concentrating the extract under reduced pressure, and drying the extract to obtain the chasteberry fruit extract; The preparation method of the composition with auxiliary blood pressure lowering effect comprises the following steps: taking green tea, gynostemma pentaphyllum, American ginseng, and cassia seed, adding water at a material-liquid ratio of 1:2-3 (kg / L), and then mixing and evenly fermenting with strain A, wherein the inoculation amount of strain A is 2%-3% of the weight of the material, to obtain fermentation product A; taking kudingcha tea, lily, Panax notoginseng leaf, and sophora japonica flower, adding water at a material-liquid ratio of 1:2-3 (kg / L), and then mixing and evenly fermenting with strain B, wherein the inoculation amount of strain B is 1%-2% of the weight of the material, to obtain fermentation product B; and uniformly mixing the fermentation product A and fermentation product B with red ramie extract and chasteberry fruit extract, and sterilizing the mixture; wherein the strain A is composed of Lactobacillus acidophilus and Lactobacillus brevis in a mass ratio of 5-6:0.8-1.2; and the strain B is composed of Saccharomyces cerevisiae and Lactobacillus plantarum in a mass ratio of 0.8-1.2:2-4. The fermentation temperature is 30-40℃ and the fermentation time is 2-3 days.

2. The composition having auxiliary blood pressure lowering effect according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 10 parts of green tea, 8 parts of gynostemma pentaphyllum, 5 parts of kudingcha tea, 8 parts of lily, 5 parts of notoginseng leaves, 10 parts of cassia seeds, 5 parts of American ginseng, 2 parts of sophora japonica flowers, 4 parts of red ramie extract and 9 parts of chasteberry fruit extract.

3. Use of the composition according to any one of claims 1 to 2 in the preparation of functional foods for assisting in lowering blood pressure.

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