Implantable targeted drug delivery device

Abstract

The application provides an implantable targeted drug delivery device, which comprises a shell, a control assembly and a medicine bag, wherein the control assembly comprises a control board, a first flow sensor, a second flow sensor and a driving pump. By integrating the control board, the first flow sensor, the second flow sensor, the driving pump and the medicine bag in the vertical direction, the implantable targeted drug delivery device is miniaturized by integrating the circuit and the medicine liquid flow path of the implantable targeted drug delivery device, and the long-term use of the implantable targeted drug delivery device is more favorable.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of medical devices, and particularly relates to an implantable targeted drug delivery device. BACKGROUND

[0002] Targeted drug delivery can accurately release drugs to specific tissues and organs, has high drug utilization efficiency, and has little toxicity to other parts of the body.

[0003] The existing implantable targeted drug delivery device, such as CN217339754U, usually lays out elements such as a medicine bag, a drive pump, a sensor and a control board in the horizontal direction, resulting in a large size in the horizontal direction and inconvenient use. Patent application CN11053956A proposes to set the transmission assembly into a U shape and set the circuit board assembly into an L shape, and the two edges of the L shape are arranged in the gap between the middle part of the U-shaped structure and the short side and the butt surface, so that the movement assembly and the circuit board assembly are complementary in the spatial structure, so as to improve the utilization rate of the shell. SUMMARY

[0004] The application aims to provide an implantable targeted drug delivery device with vertical integration different from the prior art, which has the advantages of small volume and convenient long-term use. The technical scheme of the application is as follows:

[0005] An implantable targeted drug delivery device for targeted supply of a drug liquid, comprising a shell, a control assembly and a medicine bag.

[0006] The shell comprises an upper shell, a middle shell and a lower shell arranged in sequence, an upper accommodating cavity is formed between the upper shell and the middle shell, and a lower accommodating cavity is formed between the lower shell and the middle shell, and the shell is provided with a drug liquid inlet and a drug liquid outlet.

[0007] The control assembly comprises a control board, a first flow sensor, a second flow sensor and a drive pump, the first flow sensor, the second flow sensor and the drive pump are electrically connected with the control board, the first flow sensor is configured to detect the flow of the drug liquid at the water inlet of the drive pump and feed back to the control board, the second flow sensor is configured to detect the flow of the drug liquid at the water outlet of the drive pump and feed back to the control board, and the control board receives the flow information detected by the first flow sensor and the second flow sensor and adjusts the flow of the drive pump.

[0008] The medicine bag has a cavity for containing the drug liquid, the medicine bag and the control board are located on the two sides of the middle shell respectively, the sensor assembly is located in the upper accommodating cavity or the lower accommodating cavity, and the drive pump is located in the upper accommodating cavity or the lower accommodating cavity.

[0009] The liquid inlet, the medicine bag, the drive pump, and the liquid outlet are connected in sequence. The first flow sensor is set in the liquid flow path between the medicine bag and the drive pump, and the second flow sensor is set in the liquid flow path between the drive pump and the liquid outlet.

[0010] Preferably, it further includes a tubular liquid channel, with the liquid inlet located on the upper wall of the upper shell, the medicine capsule housed in the lower cavity, the water inlet of the medicine capsule located on the upper wall of the medicine capsule, and the liquid inlet and the water inlet of the medicine capsule connected through the liquid channel.

[0011] Preferably, the control plate, the middle shell, and the medicine bag are stacked in sequence, and medicine liquid passage holes are opened at the positions corresponding to the water inlets of the control plate and the middle shell and the medicine bag, respectively, and the medicine liquid channel passes through the medicine liquid passage holes on the control plate and the middle shell.

[0012] Preferably, it also includes a base plate, which is disposed in the lower accommodating cavity, and the sensor assembly, drive pump and drug capsule are respectively fixed on the base plate.

[0013] Preferably, a drive pump receiving groove is provided in the middle of the middle shell, and the height of the side wall of the drive pump receiving groove is greater than the thickness of the main body of the middle shell.

[0014] The drug capsule has a drug capsule cover, which has a U-shaped upper wall and a side wall that is vertically downward along the outer edge of the U-shaped upper wall. The inner edge of the upper wall of the drug capsule cover has the same shape as the side wall of the drive pump receiving groove. The upper wall of the drug capsule cover is welded or bonded to the side wall of the drive pump receiving groove. The bottom of the side wall of the drug capsule cover is welded or bonded to the middle shell. The drug capsule cover, the side wall of the drive pump receiving groove, and the middle shell form a drug capsule.

[0015] Preferably, the control component further includes a flow guide plate, on which a first liquid passage and a second liquid passage that are not interconnected are formed. The flow guide plate includes a PCB board disposed below it, and the first flow sensor and the second flow sensor are respectively soldered to the PCB board.

[0016] The first flow sensor is used to detect the flow rate of the liquid medicine flowing through the first liquid medicine passage, and the second flow sensor is used to detect the flow rate of the liquid medicine flowing through the second liquid medicine passage.

[0017] The two ends of the first liquid path are connected to the inlet of the drug bag and the inlet of the drive pump, respectively, and the two ends of the second liquid path are connected to the outlet of the drive pump and the outlet of the liquid, respectively.

[0018] Preferably, the control board has two pins on its upper surface, the distance between the two pins being the length of the guide plate, and the guide plate is disposed between the two pins and electrically connected to the control board through the pins.

[0019] Preferably, the system also includes a battery, and the first flow sensor, the second flow sensor, the drive pump, and the control board are electrically connected to the battery.

[0020] Preferably, the first flow sensor and the second flow sensor are pressure sensors.

[0021] Preferably, the driving pump is a micro mechanical pump or a micro piezoelectric pump.

[0022] The present invention has at least the following beneficial effects: The control board, the first flow sensor, the second flow sensor, the drive pump and the drug capsule are integrated in the vertical direction. By integrating the circuit and drug flow path of the implantable targeted drug delivery device, the miniaturization of the implantable targeted drug delivery device is achieved, which is more conducive to the long-term use of the implantable targeted drug delivery device. Attached Figure Description

[0023] Figure 1 An exploded view of the implantable targeted drug delivery device provided in Example 1;

[0024] Figure 2 This is an exploded view of the casing and the flask in Example 1;

[0025] Figure 3 This is a top view of the shell in Example 1;

[0026] Figure 4 This is a bottom view of the shell in Example 1;

[0027] Figure 5 This is an exploded view of the drive pump in Example 1;

[0028] Figure 6 This is a longitudinal cross-sectional view of the drive pump in Example 1;

[0029] Figure 7 This is an exploded view of the deflector in Example 1;

[0030] Figure 8 This is a top view of the deflector in Example 1;

[0031] Figure 9 An exploded view of the implantable targeted drug delivery device provided in Example 2;

[0032] Figure 10 This is a top view of the first flow sensor, the second flow sensor, and the guide plate in Example 2.

[0033] The reference numerals in the figure are as follows: 110 - Upper housing; 120 - Middle housing; 1201, 1202, 1203, 1204 - Through holes; 1205 - Third sealing groove; 121 - Middle housing pin hole; 122 - First sealing groove; 123 - First sealing ring; 124 - Second sealing ring; 125 - Drive pump receiving groove; 1251 - Receiving groove pin hole; 126 - Drug sac base; 127 - Third sealing ring; 128 - Second sealing groove; 130 - Lower housing; 131 - Lower housing frame; 132 - Lower housing base plate; 140 - Liquid inlet; 141 - Sealing bolt; 150 - Liquid outlet; 151 - Liquid conduit; 210 - Drive pump; 211 - Drive pump body; 2111 - Drive pump pin hole; 2112 - Drive pump inlet; 2113 - Drive pump outlet; 212 - Fixed bracket; 2121 - Fixed bracket pin hole; 2122 - Power supply lead-out hole; 2 123-Flow channel; 213-Electric outlet; 220-Guide plate; 221-Upper plate; 2211, 2212, 2213, 2214, 2221, 2222-Guide holes; 2215-First guide channel; 2216-Second guide channel; 222-Middle plate; 223-Lower plate; 224-PCB board; 225-Wire through hole; 226-Guide hole; 227-Guide plate inlet; 228-Guide 229 - Plate outlet; 230 - First flow sensor; 240 - Second flow sensor; 250 - Control board; 251 - Pin; 260 - Liquid through hole; 270 - Sensor wire hole; 280 - Drive pump wire hole; 300 - Drug bag; 310 - Drug bag cover; 320 - Drug bag inlet; 330 - Drug bag outlet; 330 - Liquid channel; 400 - Battery; 500 - Bolt; 600 - Base plate. Detailed Implementation

[0034] The embodiments of the present invention are described below with reference to the accompanying drawings to enable those skilled in the art to better understand and implement the present invention. However, the listed embodiments are not intended to limit the present invention. In the absence of conflict, the following embodiments and the technical features in the embodiments can be combined with each other, wherein the same components are indicated by the same reference numerals.

[0035] The main improvement of this invention lies in the structure of the device; therefore, the materials of the components are not limited in the following embodiments. For example, in Embodiment 1, the materials of the drug capsule cover, upper shell, middle shell, and lower shell are titanium alloy, acrylic, PEEK, or stainless steel; the material of the fixing bracket can be acrylic, copper, titanium alloy, or stainless steel; the material of the first sealing ring, second sealing ring, and third sealing ring can be silicone rubber; the material of the upper plate, middle plate, and lower plate of the guide plate can be silicon, glass, or titanium alloy; and the upper plate, middle plate, and lower plate are connected by laser welding or chemical bonding.

[0036] Example 1

[0037] The implantable targeted drug delivery device provided in this embodiment includes a housing, a control assembly, a drug capsule 300, and a battery 400. Specifically, the housing includes an upper housing 110, a middle housing 120, and a lower housing 130. The housing is provided with a drug inlet 140 for introducing liquid medication into the implantable targeted drug delivery device and a drug outlet 150 for discharging liquid medication from the implantable targeted drug delivery device. The drug capsule 300 has a cavity for containing liquid medication. The control assembly includes a drive pump 210, a flow deflector 220, a first flow sensor 230, a second flow sensor 240, and a control board 250. The first flow sensor 230, the second flow sensor 240, and the drive pump 400... 10 are electrically connected to the control board 250 respectively. The first flow sensor 230 is configured to detect the flow rate of the medicine liquid at the inlet of the drive pump 210 and feed it back to the control board 250. The second flow sensor 240 is configured to detect the flow rate of the medicine liquid at the outlet of the drive pump 210 and feed it back to the control board 250. The control board 250 receives the flow information detected by the first flow sensor 230 and the second flow sensor 240 and adjusts the flow rate of the drive pump 210 by adjusting the input voltage and input current of the drive pump 210.

[0038] Please see Figure 1 The upper housing 110, the middle housing 120 and the lower housing 130 are connected sequentially from top to bottom. An upper accommodating cavity is formed between the upper housing 110 and the middle housing 120, and a lower accommodating cavity is formed between the middle housing 120 and the lower housing 130. The drive pump 210 and the drug capsule 300 are disposed in the upper accommodating cavity, and the guide plate 220, the control plate 250 and the battery 400 are disposed in the lower accommodating cavity.

[0039] Furthermore, in this embodiment, the middle housing 120 is provided with a plurality of middle housing pin holes 121 near its outer edge, and the upper housing 110 and lower housing 130 are respectively provided with bolts 500 at corresponding positions. Both the upper housing 110 and the lower housing 130 are connected to the middle housing 120 by the engagement of the bolts 500 with the middle housing pin holes 121. Please refer to... Figure 1 and Figure 2 The middle housing 120 has a first sealing groove 122 on its upper surface that contacts the upper housing 110. A first sealing ring 123 is placed in the first sealing groove 122. The depth of the first sealing groove 122 is less than the height of the first sealing ring 123 when not under force. When the middle housing 120 is connected to the upper housing 110, the first sealing ring 123 undergoes elastic deformation under the pressure of the upper housing 110, sealing the gap between the middle housing 120 and the upper housing 110. Similarly, the middle housing 120 has a second sealing groove 128 on its lower surface that contacts the lower housing 130. A second sealing ring 124 is placed in the second sealing groove, and the second sealing ring 124 can seal the gap between the middle housing 120 and the lower housing 130.

[0040] Continue to refer to Figure 2 A drive pump receiving groove 125 is formed in the middle of the middle shell 120. The drive pump receiving groove 125 is used to receive the drive pump 210. The side wall of the drive pump receiving groove 125 is higher than the thickness of the main body of the middle shell 120. The middle shell 120 is recessed along the outside of the drive pump receiving groove 125 to form a U-shaped drug capsule base 126. The drug capsule 300 has a drug capsule cover 310. The drug capsule cover 310 has an upper wall that is approximately U-shaped and a side wall that is vertically downward along the outer edge of the upper wall. The inner periphery of the upper wall of the drug capsule cover 310 is welded to the side wall of the drive pump receiving groove 125. The bottom of the side wall of the drug capsule cover 310 is welded to the outer periphery side wall of the drug capsule base 126, so that the drug capsule base 126, the side wall of the drive pump receiving groove 125 and the drug capsule cover 310 together form the drug capsule 300.

[0041] Figure 3 and Figure 4 The figures show a top view and a bottom view of the middle housing 120. The middle housing 120 has through holes 1201, 1202, 1203, and 1204 within the drive pump receiving groove 125. Through hole 1201 communicates with the drug capsule base 126 via a conduit; through holes 1202 and 1204 communicate with the drive pump 210; and through hole 1203 communicates with the drug outlet 150. The bottom surface of the middle housing 120 has multiple third sealing grooves 1205 arranged around the through holes. Third sealing rings 127 are placed within the third sealing grooves 1205 to seal the liquid passage between the middle housing 120 and the guide plate 220.

[0042] Furthermore, returning to Figure 2 In this embodiment, both the drug inlet 140 and the drug outlet 150 are located on the middle housing 120. The drug inlet 140 is directly connected to the drug capsule base 126. After the drug is injected, the drug inlet 140 can be sealed with a sealing bolt 141. The drug outlet 150 is provided with a drug conduit 151. The drug conduit 151 is used to guide the drug flowing back from the through hole 1203 to the middle housing 120 through the drug outlet 150 to the implantable targeted drug delivery device.

[0043] In this embodiment, as Figure 5As shown, the drive pump 210 includes a drive pump body 211, a fixed bracket 212, and two power outlets 213. The drive pump body 211 has four corner holes 2111 for fixing. The fixed bracket 212 has multiple through-holes 2121, with four of the through-holes corresponding to the drive pump holes 2111. The drive pump holes 2111 and the fixed bracket holes 2121 overlap and are fixed by bolts 500, thus fixing the drive pump body 211 in the fixed bracket 212. The power outlets 213 are bonded to both sides of the fixed bracket 212. Power outlet holes 2122 are provided on both sides of the fixed bracket 212 where the power outlets 213 are bonded. The power cord (not shown) of the drive pump body 211 is led out from the power outlet holes 2122 and connected to the power outlets 213.

[0044] Figure 6 The longitudinal cross-sectional view of the drive pump 210 shows that the drive pump body 211 has a drive pump inlet 2112 and a drive pump outlet 2113, which are vertically connected. A flow channel 2123 is formed within the fixed bracket 212. The inlet of the flow channel 2123 is located on the lower surface of the fixed bracket 212 and communicates with the through hole 1201. The flow channel 2123 extends upward from its inlet and then towards the middle to its outlet. The outlet of the flow channel 2123 communicates with the drive pump inlet 2112. The liquid medicine enters the drive pump 210 through the inlet of the flow channel 2123, then flows into the drive pump body 211 from the drive pump inlet 2112 under the guidance of the flow channel 2123, and finally flows out of the drive pump from the drive pump outlet 2113 under the pumping action of the drive pump body 211.

[0045] Figure 7 and Figure 8 The specific structure of the flow guide plate is shown. The flow guide plate 220 includes an upper plate 221, a middle plate 222, a lower plate 223, and a PCB board 224 stacked sequentially. The middle plate 222 and the upper plate 221 form the liquid path of the flow guide plate 220, from which... Figure 8As can be seen, the upper plate 221 has flow guiding holes 2211, 2212, 2213 and 2214. Flow guiding holes 2211 and 2213 are connected to form a first flow guiding plate channel 2215, and flow guiding holes 2212 and 2214 are connected to form a second flow guiding plate channel 2216. The middle plate 222 has flow guiding holes 2221 and 2222. Flow guiding hole 2221 is located below the first flow guiding plate channel 2215, and flow guiding hole 2222 is located below the second flow guiding plate channel 2216. The lower plate 223 is used to position the first flow sensor 230 and the second flow sensor 240. The first flow sensor 230 and the second flow sensor 240 are respectively soldered on the PCB board 224. The position of the first flow sensor 230 corresponds to the flow guide hole 2221, and the position of the second flow sensor 240 corresponds to the flow guide hole 2222. The first flow sensor 230 and the second flow sensor 240 respectively detect the pressure of the liquid flowing through the flow guide hole 2221 and the flow guide hole 2222, and then transmit the signal to the control board 250.

[0046] Through hole 1204 communicates with guide hole 2213, through hole 1201 communicates with guide hole 2211, through hole 1202 communicates with guide hole 2212, and through hole 1203 communicates with guide hole 2214. The liquid medicine in the medicine bag flows out of medicine bag 300 through 1204 and enters guide plate 220, and under the guidance of first guide plate channel 2215, flows through guide hole 2221 and enters drive pump 210 from 2211. The liquid medicine in drive pump 210 flows out of middle housing 120 through through hole 1202 and then enters guide plate 220 through guide hole 2212, and under the guidance of second guide plate channel 2216, flows through guide hole 2222 and exits guide plate 2214. In addition, upper plate 221, middle plate 222, lower plate 223, and PCB board 224 are each provided with wire through holes 225 at the same positions at both ends.

[0047] Back Figure 1 The control board 250 has two pins 251 on its upper surface. The distance between the two pins 251 is the length of the guide plate 220. The guide plate 220 is positioned between the two pins 251 and is electrically connected to the control board 250 through the pins 251. Each electrical outlet 213 leads out a wire (not shown in the figure). The wire passes through the drive pump receiving slot 125, the upper plate 221, the middle plate 222, the lower plate 223, and the wire through hole 225 on the PCB board 224 and is electrically connected to the control board 250, so as to realize the control board 250 control the input voltage and input current of the drive pump 210.

[0048] The battery 400 is located below the control board 250 and is used to power the control board 250, the first flow sensor 230, the second flow sensor 240 and the drive pump 210.

[0049] In this embodiment, the lower housing 130 includes a lower housing frame 131 and a lower housing base plate 132. The lower housing frame 131 and the lower housing base plate 132 are fixedly connected by bolts 500. The lower housing frame 131 runs vertically through the lower housing, and its height is approximately the height of the battery 400, control board 250 and flow guide plate 220 stacked together.

[0050] Example 2

[0051] The implantable targeted drug delivery device provided in this embodiment includes a housing, a control assembly, a drug capsule 300, and a base plate 600. The housing includes an upper housing 110, a middle housing 120, and a lower housing 130. The drug capsule 300 has a cavity for containing liquid medication. The control assembly includes a drive pump 210, a flow guide plate 220, a first flow sensor 230, a second flow sensor 240, and a control board 250. The first flow sensor 230, the second flow sensor 240, and the drive pump 210 are electrically connected to the control board 250. The first flow sensor 230 is configured to detect the flow rate of the liquid medication at the inlet of the drive pump 210 and feed it back to the control board 250. The second flow sensor 240 is configured to detect the flow rate of the liquid medication at the outlet of the drive pump 210 and feed it back to the control board 250. The control board 250 receives the flow information detected by the first flow sensor 230 and the second flow sensor 240 and adjusts the flow rate of the drive pump 210 by adjusting the input voltage and input current of the drive pump 210.

[0052] Specifically, such as Figure 9 As shown, the upper housing 110 and the lower housing 130 are engaged, and the middle housing 120 is disposed between the upper housing 110 and the lower housing 130. An upper receiving cavity is formed between the upper housing 110 and the middle housing 120, and a lower receiving cavity is formed between the lower housing 130 and the middle housing 120.

[0053] The control plate 250, the middle shell 120, and the medicine sac 300 are stacked sequentially. The control plate 250 is located in the upper accommodating cavity, the battery 400 is mounted on the control plate 250, and the medicine sac 300 is located in the lower accommodating cavity. The liquid inlet 140 is opened on the upper wall of the upper shell 110, and the water inlet 320 of the medicine sac is opened on the upper wall of the medicine sac 300. The control plate 250 and the middle shell 120 are respectively provided with liquid passage holes 260 at positions corresponding to the water inlet 320 of the medicine sac. A tubular liquid channel 330 passes through the liquid passage holes 260 on the control plate 250 and the middle shell 130 and connects the liquid inlet 140 with the water inlet 320 of the medicine sac. In addition, both the control board 250 and the middle housing 120 are provided with sensor wire holes 270 and drive pump wire holes 280. The sensor wire holes 270 on the control board 250 coincide with the sensor wire holes 270 on the middle housing 120, and the drive pump wire holes 280 on the control board 250 coincide with the drive pump wire holes 280 on the middle housing 120. The drive pump 210 and the control board 250 are electrically connected by a wire (not shown in the figure) passing through the drive pump wire hole 280.

[0054] The flow deflector 220, the first flow sensor 230, and the second flow sensor 240 constitute as follows: Figure 10 The sensor assembly shown has a guide plate 220 with two guide plate inlets 227 and two guide plate outlets 228. One guide plate inlet 227 is connected to one guide plate outlet 228, forming a first liquid path within the guide plate 220. The other guide plate inlet 227 is connected to the other guide plate outlet 228, forming a second liquid path within the guide plate 220. The first liquid path and the second liquid path are not connected to each other.

[0055] The guide plate 220 is also provided with pads 229, which are electrically connected to the control board 250 via a wire (not shown in the figure) passing through the sensor wire hole 270. The first flow sensor 230 and the second flow sensor 240 are respectively fixed to the guide plate 220 via pads 229 and electrically connected to the control board 250 via pads 229. The first flow sensor 230 is located above the first liquid passage, and the second flow sensor 240 is located above the second liquid passage, so as to detect the flow rate of the liquid in the first liquid passage and the second liquid passage.

[0056] Back Figure 9 The sensor assembly, drug capsule 300 and drive pump 210 are fixed on the base plate 600, which is placed in the lower housing 130. The lower housing 130 is provided with a drug outlet 150, and a drug conduit 151 is inserted into the drug outlet 150. The drug conduit 151 is used to deliver the drug from the drug outlet 150 to the implantable targeted drug delivery device.

[0057] The liquid inlet 140 and the inlet 320 of the medicine bag are connected through the liquid channel 330. The outlet 330 of the medicine bag, the first liquid passage, the drive pump 210, the second liquid passage and the liquid outlet 150 are connected in sequence through a conduit (not shown in the figure).

[0058] The above description is merely a preferred embodiment of the present invention, and therefore should not be construed as limiting the scope of the present invention. All equivalent changes and modifications made in accordance with the scope of the patent and the contents of the specification should still fall within the scope of the present invention.

Claims

1. An implantable targeted drug delivery device for targeted delivery of drug solution, characterized in that, Includes a housing, control components, and a drug capsule; The shell comprises an upper shell, a middle shell, and a lower shell arranged sequentially. An upper accommodating cavity is formed between the upper shell and the middle shell, and a lower accommodating cavity is formed between the lower shell and the middle shell. The shell has a liquid inlet and a liquid outlet. The control component includes a control board, a first flow sensor, a second flow sensor, and a drive pump. The first flow sensor, the second flow sensor, and the drive pump are electrically connected to the control board. The first flow sensor is configured to detect the flow rate of the liquid medicine at the inlet of the drive pump and feed it back to the control board. The second flow sensor is configured to detect the flow rate of the liquid medicine at the outlet of the drive pump and feed it back to the control board. The control board receives the flow information detected by the first flow sensor and the second flow sensor and adjusts the flow rate of the drive pump. The control component also includes a flow guide plate, on which a first liquid passage and a second liquid passage that are not interconnected are formed. The flow guide plate includes a PCB board disposed below it, and the first flow sensor and the second flow sensor are respectively soldered to the PCB board. The first flow sensor is used to detect the flow rate of the liquid medicine flowing through the first liquid medicine passage, and the second flow sensor is used to detect the flow rate of the liquid medicine flowing through the second liquid medicine passage; The two ends of the first liquid passage are connected to the drug bag and the inlet of the drive pump, respectively, and the two ends of the second liquid passage are connected to the outlet of the drive pump and the outlet of the liquid. The drug capsule has a cavity for containing liquid medicine. The drug capsule and the control plate are located on both sides of the middle shell. The guide plate, the first flow sensor and the second flow sensor are located in the upper cavity or the lower cavity. The drive pump is located in the upper cavity or the lower cavity. The liquid inlet, the medicine bag, the drive pump, and the liquid outlet are connected in sequence. The first flow sensor is set in the liquid flow path between the medicine bag and the drive pump, and the second flow sensor is set in the liquid flow path between the drive pump and the liquid outlet.

2. The implantable targeted drug delivery device as described in claim 1, characterized in that, It also includes a tubular liquid medicine channel, the liquid medicine inlet is opened on the upper wall of the upper shell, the medicine bag is housed in the lower accommodating cavity, the water inlet of the medicine bag is opened on the upper wall of the medicine bag, and the liquid medicine inlet and the water inlet of the medicine bag are connected through the liquid medicine channel.

3. The implantable targeted drug delivery device as described in claim 2, characterized in that, The control plate, the middle shell, and the medicine bag are stacked in sequence. The control plate and the middle shell are respectively provided with medicine liquid through holes at the positions corresponding to the water inlet of the medicine bag. The medicine liquid channel passes through the medicine liquid through holes on the control plate and the middle shell.

4. The implantable targeted drug delivery device as described in claim 3, characterized in that, It also includes a base plate disposed in the lower accommodating cavity, and the guide plate, the first flow sensor, the second flow sensor, the drive pump and the drug capsule are respectively fixed on the base plate.

5. The implantable targeted drug delivery device as described in claim 1, characterized in that, A drive pump receiving groove is provided in the middle of the middle housing, and the height of the side wall of the drive pump receiving groove is greater than the thickness of the main body of the middle housing. The drug capsule has a drug capsule cover, which has a U-shaped upper wall and a side wall that is vertically downward along the outer edge of the U-shaped upper wall. The inner edge of the upper wall of the drug capsule cover has the same shape as the side wall of the drive pump receiving groove. The upper wall of the drug capsule cover is welded or bonded to the side wall of the drive pump receiving groove. The bottom of the side wall of the drug capsule cover is welded or bonded to the middle shell. The drug capsule cover, the side wall of the drive pump receiving groove, and the middle shell form the drug capsule.

6. The implantable targeted drug delivery device as described in claim 1, characterized in that, The control board has two pins on its upper surface, the distance between the two pins being the length of the guide plate, and the guide plate is disposed between the two pins and electrically connected to the control board through the pins.

7. The implantable targeted drug delivery device as described in claim 1, characterized in that, It also includes a battery, and the first flow sensor, the second flow sensor, the drive pump and the control board are electrically connected to the battery.

8. The implantable targeted drug delivery device as described in claim 1, characterized in that, The first flow sensor and the second flow sensor are pressure sensors.

9. The implantable targeted drug delivery device as described in claim 1, characterized in that, The drive pump is a micro mechanical pump.

10. The implantable targeted drug delivery device as claimed in claim 1, characterized in that, The drive pump is a miniature piezoelectric pump.

Images