A biological product purification efficiency detection device

Abstract

The present invention belongs to the technical field of biological product purification, and in particular to a biological product purification efficiency detection device, comprising a liquid chromatography detector shell, a solvent box installed on the top surface thereof for holding a solvent bottle, each of the diamond-shaped edge grooves is hinged with an L-shaped solvent clamping rod component with an included angle less than degrees, the bottom ends of the two L-shaped solvent clamping rod components arranged opposite to each other are hinged and slidably connected to each other, and their common bottom surface is connected to a solvent buffer air spring component for shock absorbing the solvent bottle, the solvent buffer air spring component is fixed on the inner bottom wall of an adapter mounting tube, and the top surface of the end portions thereof that are hinged and slidably connected to each other is provided with a bearing and pressing base for bearing the solvent bottle to press downward, the top ends of the two L-shaped solvent clamping rod components are hinged with a solvent stabilizing splint that can drive the L-shaped solvent clamping rod components to flip centripetally and clamp them to the solvent bottle as the bearing and pressing base descends.

Description

Technical Field

[0001] The invention belongs to the technical field of biological product purification, in particular to a biological product purification efficiency detection device. Background Art

[0002] The detection of purification efficiency of biological products usually involves the determination of key parameters such as product purity, impurity content, and target component concentration to evaluate the effectiveness of the purification process and product quality. As a widely used analytical technique with high sensitivity and strong separation ability, high performance liquid chromatography (HPLC) is indeed of great value for the detection of purification efficiency of biological products. The system of high performance liquid chromatography consists of several parts such as reservoir, pump, injector, chromatographic column, detector, recorder, etc. The mobile phase in the reservoir is pumped into the system by a high-pressure pump, and the sample solution enters the mobile phase through the injector and is carried into the chromatographic column (stationary phase) by the mobile phase. Since the components in the sample solution have different distribution coefficients in the two phases, when they move relative to each other in the two phases, after repeated adsorption-desorption distribution processes, the components have large differences in movement speed, are separated into individual components and flow out of the column in turn, and when passing through the detector, the sample concentration is converted into an electrical signal and transmitted to the recorder.

[0003] The solvent box of the existing liquid chromatograph is used to place the solvent bottle. When in use, the solvent bottle is connected to other instruments through a hose. At the same time, the stability of the solvent bottle is not enough when it is directly placed inside the solvent box. There is a lack of a clamping, buffering and shock-absorbing structure for the solvent bottle. If the hose is accidentally touched or the solvent box is collided during operation, the solvent bottle may easily fall or fall, which is not safe enough.

[0004] After searching, such as the existing Chinese patent publication number: CN220251838U, a liquid chromatograph includes a liquid chromatograph body, the top of the liquid chromatograph body is fixedly connected with a sample placement chamber, the inner side of the sample placement chamber is fixedly connected with a storage box and a placement rack, one side of the sample placement chamber is slidably connected with a connecting rod, one side of the connecting rod is slidably connected with a driving rod, the inner side of the driving rod is slidably connected with two data comparison blocks, and the inner side of the sample placement chamber is slidably connected with a plurality of data recording blocks; through the cooperation of the sample placement chamber and the data recording blocks, the staff can record the test results of each group of samples more conveniently and quickly.

[0005] The cited patent document also has the same problem. When in use, the solvent bottle is connected to other instruments through a hose. At the same time, the solvent bottle is not stable enough when placed directly inside the solvent box. There is a lack of a clamping, buffering and shock-absorbing structure for the solvent bottle. If the hose is accidentally touched or the solvent box is collided during operation, the solvent bottle may easily tip over or fall, which is not safe enough. Summary of the invention

[0006] The purpose of the present invention is to provide a biological product purification efficiency detection device to solve the problems raised in the background technology.

[0007] To achieve the above-mentioned object, the present invention provides the following technical solutions: A biological product purification efficiency detection device, comprising a liquid chromatograph detector housing, a solvent box installed on the top surface thereof for holding a solvent bottle, a detachable top cover is provided on the top of the solvent box, and an adapter installation cylinder for installing a solvent bottle to prevent tipping is provided in the inner cavity of the solvent box;

[0008] Two diamond-shaped grooves are symmetrically provided on the inner wall of the adapter mounting cylinder, and each of the diamond-shaped grooves is hinged with an L-shaped solvent clamping rod component with an included angle less than degrees. The bottom ends of the two relatively arranged L-shaped solvent clamping rod components are hinged and slidably connected to each other, and their common bottom surface is connected to a solvent buffer air spring component for shock absorbing the solvent bottle. The solvent buffer air spring component is fixed on the inner bottom wall of the adapter mounting cylinder, and the top surface of the end portion thereof that is hinged and slidably connected to each other is provided with a bearing and pressing base for bearing the solvent bottle to press downward, and the top ends of the two L-shaped solvent clamping rod components are hinged with a solvent stabilizing splint that can drive the L-shaped solvent clamping rod component to flip centripetally and clamp itself on the solvent bottle as the bearing and pressing base descends.

[0009] Preferably, the L-shaped solvent clamping rod member includes a centripetally tilted rod member and a downwardly tilted rod member;

[0010] The ends of the two parts connected as one body are hinged to the groove of the diamond-shaped edge through a first pin.

[0011] Preferably, a travel slot is opened inside the free end of one of the downward-flipping and tilting rods, and the free end of the other downward-flipping and tilting rod is clamped in a U-shape on both sides of the travel slot and a travel limit pin is passed through the travel slot to fix a limit plug.

[0012] Preferably, two inclined support rods are hinged on both side outer walls of the two downwardly flipped inclined rods, and the top end of each of the inclined support rods is hinged to the bottom surface of the bearing and pressing base.

[0013] In this solution, the inner walls of the top ends of the two centripetally tilted rods are symmetrically welded with hinged ear plates, and the back side of each solvent stabilizing splint is welded with a hinged protrusion;

[0014] The hinged protrusion is placed in two adjacent hinged ear plates and is hinged via a second pin shaft.

[0015] Preferably, the top surface of the adapter installation cylinder is symmetrically and longitudinally provided with two counterweight placement holes;

[0016] The bottom end of each counterweight placement hole extends longitudinally downward and penetrates into the adjacent diamond-cornered edge groove.

[0017] Preferably, a counterweight locking block is placed in each of the counterweight placement holes. When the L-shaped solvent clamping rod component is centripetally flipped and clamped on the solvent bottle, the counterweight locking block drops due to its own weight and abuts against the outer wall of the centripetally flipped inclined rod component to achieve locking and limiting.

[0018] In this solution, preferably, a first lifting ring is fixed to the top surface of each counterweight placement hole and located at the top of the adapter installation tube, and a second lifting ring is fixed to the top surface of the counterweight locking block;

[0019] A hoisting rope is connected between the first hoisting ring and the second hoisting ring.

[0020] Preferably, the inner cavity of the solvent box is also provided with a lifting assembly for lifting the adapter mounting cylinder for taking the solvent bottle, and the lifting assembly includes a servo motor fixed to the inner bottom wall of the solvent box, a screw fixed to the output shaft of the servo motor, and a lifting ring fixedly sleeved on the outer wall of the adapter mounting cylinder.

[0021] Preferably, a connecting plate is fixed to the upper part of the inner wall of the solvent box, the top end of the screw rod is embedded in the connecting plate through a bearing, and the outer wall of the lifting ring is welded with a T-shaped connecting block which is longitudinally penetrated by the screw and is in sliding friction contact with the inner wall of the solvent box.

[0022] Compared with the prior art, the technical effects and advantages of the present invention are as follows:

[0023] 1. This biological product purification efficiency testing equipment ensures the stability of mobile phase delivery by firmly clamping the solvent bottle, reduces the flow rate fluctuation caused by the shaking of the solvent bottle, thereby reducing the peak shape variation of liquid chromatography, improving the separation degree and quantitative accuracy, and ensuring the reliability of biological product purity and impurity analysis; prevents the solvent bottle from accidentally tipping over or sliding, avoids potential solvent leakage, environmental pollution and laboratory safety accidents, and ensures the safety of operators and the integrity of instruments and equipment;

[0024] 2. The built-in solvent buffer air spring can effectively absorb the impact and vibration that may occur during operation, reduce damage to the precision components inside the liquid chromatograph, and help extend the service life of the instrument; convenient and quick installation and replacement of solvent bottles, simplifying maintenance work, reducing analysis interruptions and recalibration time caused by bottle fixing problems, and improving the efficiency of the entire biological product purification and testing process. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0026] Figure 1 It is a structural schematic diagram of the present invention;

[0027] Figure 2 It is a schematic structural diagram of the solvent box and the detachable top cover of the present invention in a disassembled state;

[0028] Figure 3 It is a schematic structural diagram of the adapter and installation cylinder and the solvent bottle of the present invention in a disassembled state;

[0029] Figure 4 It is a structural schematic diagram of the connection state of the screw rod and the adapter installation barrel of the present invention;

[0030] Figure 5 It is a structural schematic diagram of the installation state of the load-bearing and pressing base and the solvent stabilizing clamp of the present invention;

[0031] Figure 6 It is a schematic structural diagram of the solvent buffer air spring component of the present invention in an installed state;

[0032] Figure 7 It is a schematic structural diagram of the connection state of two downwardly tilted rods of the present invention;

[0033] Figure 8 For the present invention Figure 5 A schematic diagram of the enlarged structure at A in the middle;

[0034] Fig. 9 It is a cross-sectional view of the adapter installation cylinder of the present invention.

[0035] Description of reference numerals:

[0036] In the figure: 1. Liquid chromatograph housing; 2. Solvent box; 3. Removable top cover; 4. Operation control panel; 5. Connecting pipe; 6. Guide rail frame; 7. Adapter mounting cylinder; 8. Solvent bottle; 9. Connecting plate; 10. Lifting assembly;

[0037] 11. Removable side panel; 12. Perforation; 13. First lifting ring; 14. Counterweight placement hole; 15. Solvent stabilizing clamp; 16. Bearing; 17. Screw; 18. T-type connection block; 19. Lifting collar; 20. Servo motor;

[0038] 21. Centripetal tilting rod; 22. First pin shaft; 23. Counterweight locking block; 24. Second lifting ring; 25. Inclined abutting slope; 26. Lifting rope; 27. Load-bearing pressing base; 28. Downward tilting rod; 29. ​​Solvent buffer air spring; 30. Inclined support rod;

[0039] 31. travel through groove; 32. travel limit pin; 33. first pin hole; 34. limit plug; 35. hinged ear plate; 36. hinged protrusion; 37. second pin; 38. diamond-corner groove; 39. second pin hole. DETAILED DESCRIPTION

[0040] In the following description, a large number of specific details are provided to provide a more thorough understanding of the present invention. However, it is apparent to those skilled in the art that the present invention can be implemented without one or more of these details. In other examples, in order to avoid confusion with the present invention, some technical features well known in the art are not described.

[0041] Unless otherwise defined, the up, down, left, right, front, back, inside and outside directions involved in this document are based on the up, down, left, right, front, back, inside and outside directions in the figures shown in the present invention, and are explained here together.

[0042] This embodiment discloses Figures 1 to 9 A biological product purification efficiency detection device shown in the figure includes a liquid chromatography detector housing 1, a solvent box 2 installed on the top surface of the liquid chromatography detector housing 1 by screws for holding a solvent bottle 8, a removable top cover 3 is installed on the top of the solvent box 2 by bolts, an operation control panel 4 is installed on the front side of the liquid chromatography detector housing 1 by screws, a connecting pipe 5 is connected to the upper part of the side wall of the liquid chromatography detector housing 1, and a guide frame 6 is installed on the back outer wall of the liquid chromatography detector housing 1 by bolts for installation on a fixed object to move the liquid chromatography detector housing 1 for use, a removable side panel 11 is installed on the outer wall of one side of the solvent box 2 by screws, and a plurality of through holes 12 for the solvent hose to pass through are embedded in the detachable side panel 11, so as to facilitate the arrangement of the hose and make it more tidy.

[0043] In this embodiment, the solvent box 2 is made of high-strength, corrosion-resistant materials such as stainless steel or engineering plastics, and has sufficient rigidity to support the internal structure and the solvent bottle 8. The removable top cover 3 is designed to be easily opened and closed and tightly matched with the solvent box 2. The base of the liquid chromatography detector housing 1 should have good stability and load-bearing capacity, and an anti-skid pad can be installed at the bottom to enhance the fixation of the device on the laboratory table.

[0044] In this embodiment, an adapter mounting cylinder 7 for mounting a solvent bottle 8 to prevent tipping is placed in the inner cavity of the solvent box 2, and two diamond-shaped grooves 38 are symmetrically provided on the inner wall of the adapter mounting cylinder 7. An L-shaped solvent clamping rod component with an angle less than 90 degrees is hinged in each diamond-shaped groove 38 through a first pin shaft 22. The L-shaped solvent clamping rod component includes a centripetally flipped inclined rod member 21 and a downwardly flipped inclined rod member 28, and the ends of the two integrally connected are hinged to the diamond-shaped groove 38 through the first pin shaft 22, and a second pin hole 39 for installing the first pin shaft 22 is provided on the inner wall of the diamond-shaped groove 38.

[0045] In this embodiment, the centripetal tilting rod 21 and the downward tilting rod 28 are usually connected to each other through a hinge structure to form a movable clamping frame. When the load-bearing pressing base 27 is subjected to the pressure of the weight of the solvent bottle 8, the downward tilting rod 28 will flip inward along a preset trajectory, while driving the centripetal tilting rod 21 to flip toward the center. This linkage design ensures that when the solvent bottle 8 is put in or taken out, the clamping mechanism can automatically adapt to the contour of the bottle body to achieve adaptive clamping and release.

[0046] In this embodiment, the bottom ends of the two L-shaped solvent clamping rod components arranged opposite to each other are hinged and slidably connected together, and a travel slot 31 is provided inside the free end of one of the downward-flipped and tilted rods 28, and the free end of the other downward-flipped and tilted rod 28 is clamped in a U-shape on both sides of the travel slot 31 and a travel limit pin 32 passes through the travel slot 31 to fix a limit plug 34, and the free end of the downward-flipped and tilted rod 28 is provided with a first pin hole 33 for the travel limit pin 32 to pass through.

[0047] In this embodiment, the common bottom surface of the two relatively arranged L-shaped solvent clamping rod components abuts against a solvent buffer air spring component 29 for shock absorbing the solvent bottle 8. The solvent buffer air spring component 29 is installed on the inner bottom wall of the adapter mounting tube 7 by bolts, and the top surfaces of the ends thereof that are hingedly and slidably connected to each other are provided with a bearing and pressing base 27 for bearing the solvent bottle 8 and pressing it downward. The top ends of the two L-shaped solvent clamping rod components are hingedly connected with a solvent stabilizing clamp 15 that can drive the L-shaped solvent clamping rod components to flip centripetally and clamp them on the solvent bottle 8 as the bearing and pressing base 27 descends.

[0048] In this embodiment, the solvent stabilizing splint 15 is manufactured to match the shape of the solvent bottle 8, and is hinged to the centripetal flip and tilt rod 21, and an anti-skid pad or coating is added to the inner side of the solvent stabilizing splint 15 to increase the friction with the surface of the solvent bottle 8. When the solvent bottle 8 does not need to be clamped, the arc-shaped surface on the back of the solvent stabilizing splint 15 abuts against the inner wall of the adapter mounting tube 7, and the centripetal flip and tilt rod 21 is accommodated in the diamond-shaped edge groove 38.

[0049] In this embodiment, the load-bearing pressing base 27 serves as the basic supporting component of the clamping mechanism. It directly contacts the bottom of the solvent bottle 8, bears the weight of the solvent bottle 8 and transmits the pressure to the tilting rod system. The base is usually designed to have good wear resistance and chemical corrosion resistance to cope with the erosion that may be caused by long-term contact with the solvent. Its smooth surface and appropriate hardness help to maintain good contact with the solvent bottle 8 and ensure uniform pressure distribution.

[0050] In this embodiment, the solvent buffer air spring member 29 is installed inside the clamping mechanism by bolts, and is usually located between the inclined rod and the solvent box 2. The solvent buffer air spring member 29 can generate a reverse force when subjected to pressure changes, provide dynamic buffering, absorb the impact force caused by instrument vibration, fluid pulse or operator's accidental contact, and thus reduce the disturbance to the solvent bottle 8. This shock-absorbing design helps to maintain the stable state of the solvent bottle 8 during the analysis process, and reduces the problems of unstable solvent flow and poor liquid chromatography peak shape caused by the shaking of the bottle.

[0051] In this embodiment, the solvent stabilizing clamp 15 is a part that directly contacts and fixes the solvent bottle 8. The stabilizing clamp is usually made of wear-resistant and chemically compatible materials and is designed with anti-skid patterns or coatings to increase the friction with the surface of the solvent bottle 8. When the centripetal tilting rod 21 turns inward along with the downward tilting rod 28, the solvent clamp will cling to the outer wall of the solvent bottle 8 to form a stable clamping force to prevent the bottle from moving in the horizontal direction. The design of the clamp needs to take into account the range of variation of the bottle diameter to ensure adaptability to solvent bottles 8 of different specifications.

[0052] In this embodiment, the stable solvent bottle 8 reduces the fluctuation of the mobile phase, helps the liquid chromatography system to obtain a sharper and more symmetrical peak shape, improves the separation and detection sensitivity, and thus improves the qualitative and quantitative accuracy of the sample components. The stable solvent supply helps to ensure the consistency of conditions between multiple analyses and enhances the repeatability of experimental results, which is crucial for the accurate evaluation of the purification efficiency of biological products. In addition, the stable solvent bottle 8 clamping design reduces the risk of liquid leakage caused by accidental movement or tipping of the bottle, thereby improving the safety of laboratory operations.

[0053] In this embodiment, two inclined support rods 30 are hinged on both side outer walls of the two downward-turned inclined rods 28 through pins, and the top of each inclined support rod 30 is hinged to the bottom surface of the bearing and pressing base 27 through a pin to support the bearing and pressing base 27.

[0054] In this embodiment, hinged ear plates 35 are symmetrically welded on the inner walls of the top ends of the two centripetal flipped and inclined rods 21, and a hinged protrusion 36 is welded on the back side of each solvent stabilizing splint 15. The hinged protrusion 36 is placed in two adjacent hinged ear plates 35 and is hinged through a second pin shaft 37.

[0055] In this embodiment, two counterweight placement holes 14 are symmetrically and longitudinally opened on the top surface of the adapter installation tube 7, and the bottom end of each counterweight placement hole 14 extends longitudinally downward to pass through the adjacent diamond-shaped edge groove 38, and a counterweight locking block 23 is placed in each counterweight placement hole 14. When the L-shaped solvent clamping rod component is centripetally flipped and clamped on the solvent bottle 8, the counterweight locking block 23 descends due to its own weight and abuts against the outer wall of the centripetally flipped inclined rod 21 to achieve locking and limiting. A first lifting ring 13 is threadedly connected to the side of each counterweight placement hole 14 and located on the top surface of the adapter installation tube 7, and a second lifting ring 24 is fixed to the top surface of the counterweight locking block 23, and a lifting rope 26 is connected between the first lifting ring 13 and the second lifting ring 24.

[0056] In this embodiment, the counterweight locking block 23 is designed and manufactured according to the required clamping force to ensure that it can slide freely along the counterweight placement hole 14 under the action of its own weight, and can effectively abut the outer wall of the centripetal flip and tilt rod 21. At the same time, the bottom of the counterweight locking block 23 has an inclined abutting slope 25 that is in close contact and friction with the outer wall of the centripetal flip and tilt rod 21.

[0057] In this embodiment, a lifting component 10 is also provided in the inner cavity of the solvent box 2 for lifting the adapter mounting cylinder 7 for taking the solvent bottle 8. The lifting component 10 includes a servo motor 20 fixed to the inner bottom wall of the solvent box 2 and a screw 17 fixed to the output shaft of the servo motor 20, and a lifting ring 19 fixedly sleeved on the outer wall of the adapter mounting cylinder 7. A connecting plate 9 is fixed to the upper part of the inner wall of the solvent box 2. The top polished rod of the screw 17 is embedded in the connecting plate 9 through a bearing 16. The outer wall of the lifting ring 19 is welded with a T-shaped connecting block 18 that is longitudinally penetrated by the screw 17 and is in sliding and frictional contact with the inner wall of the solvent box 2.

[0058] In this embodiment, a PLC for controlling the opening and closing of various components is provided inside the housing 1 of the liquid chromatograph detector and inside the operation control panel 4. The model of the PLC can be selected according to actual needs.

[0059] Working principle:

[0060] The biological product purification efficiency detection device places the solvent bottle 8 in the clamping mechanism, and the bottom of the bottle contacts the load-bearing pressing base 27, exerting downward pressure, and the load-bearing pressing base 27 transmits the pressure to the downward flipping tilting rod 28, causing the entire clamping frame to flip inward, and under the action of the first pin 22, the downward flipping tilting rod 28 flips downward, and the centripetal flipping tilting rod 21 rotates inward (centripetally) accordingly, driving the solvent stabilizing clamping plate 15 to be close to the outer wall of the solvent bottle 8, thereby achieving radial clamping;

[0061] The counterweight locking block 23 is designed and manufactured according to the required clamping force to ensure that it can slide freely along the counterweight placement hole 14 under the action of its own weight. The counterweight locking block 23 is hoisted in the counterweight placement hole 14 and slides down due to its own weight and can effectively abut against the outer wall of the centripetal flip tilt rod 21, thereby locking the centripetal flip tilt rod 21 and clamping the solvent bottle 8.

[0062] During the operation of the instrument, the solvent buffer air spring 29 absorbs the impact and vibration from the outside in real time, keeps the solvent bottle 8 stable in the clamped state, and reduces the flow rate fluctuation caused by the shaking of the bottle body. When the solvent bottle 8 needs to be replaced, through appropriate operations such as releasing the clamping mechanism locking device or manually adjusting the angle of the tilting rod, pull the lifting rope 26 to remove the counterweight locking block 23 to release the clamping of the solvent bottle 8, and then easily take out the old bottle and replace it with a new bottle.

[0063] It should be noted that, in this article, relational terms such as one and two are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions. The sentence "includes an element defined by ... does not exclude the existence of other identical elements in the process, method, article or device including the element".

[0064] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A biological product purification efficiency detection device, comprising a liquid chromatography detector housing (1), a solvent box (2) mounted on the top surface thereof for holding a solvent bottle (8), a detachable top cover (3) being provided on the top of the solvent box (2), characterized in that: An adaptor mounting cylinder (7) for mounting a solvent bottle (8) to prevent tipping is provided in the inner cavity of the solvent box (2); Two diamond-shaped grooves (38) are symmetrically formed on the inner wall of the adapter mounting tube (7), and an L-shaped solvent clamping rod component with an included angle less than 90 degrees is hinged in each of the diamond-shaped grooves (38). The bottom ends of the two L-shaped solvent clamping rod components arranged opposite to each other are hingedly slidably connected to each other, and their common bottom surface is connected to a solvent buffer air spring component (29) for shock absorption of the solvent bottle (8). The solvent buffer air spring component (29) is fixed to the inner bottom wall of the adapter mounting tube (7), and the top surface of the end portion thereof hingedly slidably connected to each other is provided with a bearing pressing base (27) for bearing the solvent bottle (8) to press downward. The top ends of the two L-shaped solvent clamping rod components are hingedly connected to a solvent stabilizing clamp (15) that can drive the L-shaped solvent clamping rod component to flip centripetally and clamp the solvent bottle (8) as the bearing pressing base (27) descends. The L-shaped solvent clamping rod component comprises a centripetally tilted rod (21) and a downwardly tilted rod (28); The ends of the two parts connected as one body are hinged to the diamond-corner groove (38) via a first pin shaft (22); A travel slot (31) is formed inside the free end of one of the downwardly tilted rods (28), and the free end of the other downwardly tilted rod (28) is clamped in a U-shape on both sides of the travel slot (31) and is fixed to a limit stopper (34) by a travel limit pin (32) passing through the travel slot (31); Two inclined support rods (30) are hingedly connected to the outer walls of both sides of the two downwardly tilted rods (28), and the top end of each of the inclined support rods (30) is hingedly connected to the bottom surface of the bearing and pressing base (27); The inner walls of the top ends of the two centripetally tilted rods (21) are symmetrically welded with hinged ear plates (35), and the back side of each solvent stabilizing clamp (15) is welded with a hinged protrusion (36); The hinged protrusion (36) is placed in two adjacent hinged ear plates (35) and is hinged via a second pin shaft (37); The top surface of the adapter installation cylinder (7) is symmetrically and longitudinally provided with two counterweight placement holes (14); The bottom end of each of the counterweight placement holes (14) extends longitudinally downward and penetrates into the adjacent diamond-cornered edge groove (38); A counterweight locking block (23) is placed in each of the counterweight placement holes (14); when the L-shaped solvent clamping rod component is centripetally turned over and clamped on the solvent bottle (8), the counterweight locking block (23) descends due to its own weight and abuts against the outer wall of the centripetally turned and inclined rod (21) to achieve locking and limiting; A first lifting ring (13) is fixed to the top surface of each counterweight placement hole (14) and located at the side of the adapter installation tube (7), and a second lifting ring (24) is fixed to the top surface of the counterweight locking block (23); A lifting rope (26) is connected between the first lifting ring (13) and the second lifting ring (24).

2. A biological product purification efficiency detection device according to claim 1, characterized in that: A lifting assembly (10) for lifting the adapter mounting cylinder (7) to take out the solvent bottle (8) is also provided in the inner cavity of the solvent box (2), and the lifting assembly (10) comprises a servo motor (20) fixed to the inner bottom wall of the solvent box (2), a screw (17) fixed to the output shaft of the servo motor (20), and a lifting collar (19) fixedly sleeved on the outer wall of the adapter mounting cylinder (7).

3. A biological product purification efficiency detection device according to claim 2, characterized in that: A connecting plate (9) is fixed to the upper part of the inner wall of the solvent box (2); the top end of the screw rod (17) is embedded in the connecting plate (9) via a bearing (16); and a T-shaped connecting block (18) is welded to the outer wall of the lifting ring (19), which is longitudinally penetrated by the screw rod (17) and is in sliding friction contact with the inner wall of the solvent box (2).

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