An electrodialysis single particle inductively coupled plasma mass spectrometry sampling device

Abstract

The present invention discloses an electrodialysis single-particle inductively coupled plasma mass spectrometry sampling device, which comprises an upper clamping plate, a lower clamping plate, an anode electrode, a first gasket, a cation exchange membrane, an upper isolation liquid channel, a second gasket, an upper dialysis membrane, an upper receiving liquid channel, a third gasket, a lower dialysis membrane, a sample channel, a fourth gasket, an anion exchange membrane, a lower receiving liquid channel, a fifth gasket, a cathode electrode, and a lower isolation liquid channel. Under the action of an electric field, after a test sample passes through the sample channel, cations and anions respectively enter the receiving liquid channel composed of a dialysis membrane and an ion exchange membrane and are carried away by the receiving liquid; only uncharged neutral particles and nanoparticles that cannot pass through the dialysis membrane remain in the sample, thereby achieving online removal of dissolved ions, quickly reducing background dissolved ions and other interfering molecules in the sample, reducing interference in mass spectrometry detection, and enabling mass spectrometry detection to have a lower particle size detection limit. The device has excellent prospects for promotion and application.

Description

Technical Field

[0001] The invention relates to the technical field of mass spectrometry detector sample injection devices, and in particular to an electrodialysis single particle inductively coupled plasma mass spectrometry sample injection device. Background Art

[0002] The properties and effects of nanomaterials are closely related to their size, surface chemistry, aggregation state, solubility, etc. Therefore, the development of theories and technologies related to the precise measurement of nanoparticles is of great significance for nanotechnology research. The characterization methods of nanomaterials mainly include dynamic light scattering, scanning and transmission electron microscopy, atomic force microscopy, differential centrifugation, field flow fractionation and other methods. Due to the complexity of nanomaterials, a single method can usually only obtain one or several physical and chemical properties of nanomaterials; in addition, methods with complex processes and poor detection limits are difficult to be widely used in the analysis of actual samples. As a type of emerging pollutants, metal nanoparticles (MNPs) are increasingly used in the fields of automotive manufacturing, biomedicine, environmental governance, cosmetics production, national defense security and energy. During their production and use, they inevitably enter the environment and enter the food chain with a biomagnification effect, posing a serious threat to animal and human health.

[0003] Single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) is a recently developed novel nanoparticle characterization technique. It can simultaneously determine the number concentration, elemental composition, and size distribution of nanoparticles in small samples. Its advantages, such as minimal sample-matrix effects from a high-temperature ion source and direct solution injection, make it a promising candidate for nanoparticle measurement. However, the analysis of MNPs in complex matrices presents significant challenges. Background dissolved ions can degrade SP-ICP-MS analytical performance, increasing the resolvable nanoparticle size and reducing the number of nanoparticles detected. For typical nanoparticles, the particle size that can be measured by SP-ICP-MS is approximately 20 nm. Reducing dissolved ions in the sample matrix is ​​crucial for increasing the detectable particle size and accurately measuring single-particle elements. Therefore, rapidly removing dissolved ions from samples remains a major challenge for SP-ICP-MS. Summary of the Invention

[0004] To overcome the shortcomings of existing detection technologies, the present invention combines electrodialysis technology with SP-ICP-MS to form an ED-SP-ICP-MS device, which can achieve efficient online removal of dissolved ions in samples, improve the resolution of particle signals and ion signals, reduce the particle size of measurable nanoparticles, and establish a highly versatile strategy that is suitable for a variety of nanoparticles at the same time and can quickly remove dissolved ions online. Ultimately, it achieves accurate multi-parameter detection of nanoparticles in complex matrices and uses it for actual sample detection.

[0005] In order to achieve the above technical effects, the following technical solutions are adopted:

[0006] An electrodialysis single particle inductively coupled plasma mass spectrometry sampling device, comprising:

[0007] From top to bottom or bottom to top, they are: upper clamping piece, anode electrode, gasket one, cation exchange membrane, gasket two, upper dialysis membrane, gasket three, lower dialysis membrane, gasket four, anion exchange membrane, gasket five, cathode electrode, lower clamping piece; the upper clamping piece and the lower clamping piece are used to clamp the sample injection device and seal the components;

[0008] The middle of the gasket is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket, the anode electrode and the cation exchange membrane are clamped to form an upper isolation liquid channel;

[0009] The middle of the second gasket is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the second gasket, the cation exchange membrane and the upper dialysis membrane are clamped to form an upper receiving liquid channel;

[0010] The middle of the gasket three is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket three, the upper dialysis membrane and the lower dialysis membrane are clamped to form a sample channel;

[0011] The middle of the gasket 4 is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket 4, the lower dialysis membrane and the anion exchange membrane are clamped to form a lower receiving liquid channel;

[0012] The middle of the gasket 5 is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket 5, the anion exchange membrane and the cathode electrode are clamped to form a lower isolation liquid channel;

[0013] The upper spacer liquid passes through the upper clamping piece and enters the upper spacer liquid channel to form an upper spacer liquid inlet channel; after the upper spacer liquid flows to the other end of the upper spacer liquid channel, it is discharged from the injection device through the other end of the upper clamping piece to form an upper spacer liquid outlet channel;

[0014] The upper receiving liquid passes through the upper clamping sheet, the first gasket, and the cation exchange membrane in sequence, and enters the upper receiving liquid channel to form an upper receiving liquid inlet channel; after the upper receiving liquid flows to the other end of the upper receiving liquid channel, it passes through the cation exchange membrane, the first gasket, and the other end of the upper clamping sheet and is discharged from the injection device to form an upper receiving liquid outlet channel;

[0015] The sample passes through the upper clamping sheet, gasket 1, cation exchange membrane, gasket 2, and upper dialysis membrane in sequence into the sample channel to form a sample inlet channel; after the sample flows to the other end of the sample channel, it passes through the upper dialysis membrane, gasket 2, cation exchange membrane, gasket 1, and the other end of the upper clamping sheet to exit the sample injection device to form a sample outlet channel;

[0016] The lower receiving liquid passes through the lower clamping sheet, the fifth gasket, and the anion exchange membrane in sequence, and enters the lower receiving liquid channel to form a lower receiving liquid inlet channel; after the lower receiving liquid flows to the other end of the lower receiving liquid channel, it passes through the anion exchange membrane, the fifth gasket, and the other end of the lower clamping sheet to discharge the sample injection device to form a lower receiving liquid outlet channel;

[0017] The lower isolation liquid passes through the lower clamping piece and enters the lower isolation liquid channel to form a lower isolation liquid inlet channel; after the lower isolation liquid flows to the other end of the lower isolation liquid channel, it is discharged from the sampling device through the other end of the lower clamping piece to form a lower isolation liquid outlet channel.

[0018] Furthermore, the cathode electrode and the anode electrode are metal titanium electrodes.

[0019] Furthermore, the upper and lower clamping plates are made of polymethyl methacrylate (PMMA).

[0020] Furthermore, the gasket is made of silicone.

[0021] Furthermore, the cation exchange membrane includes a polymer ion exchange membrane, an inorganic ion exchange membrane and a composite ion exchange membrane.

[0022] Furthermore, the dialysis membrane includes regenerated cellulose membrane, cellulose acetate membrane, alternative cellulose membrane, and synthetic membrane.

[0023] Furthermore, the anion exchange membrane includes a polymer ion exchange membrane, an inorganic ion exchange membrane and a composite ion exchange membrane.

[0024] Furthermore, the isolation liquid is composed of water. The receiving liquid is composed of water.

[0025] Furthermore, the voltage between the positive and negative electrodes of the injection device is 5-25V; the injection speed of the isolation liquid is 0.1-1.0mL / min; the injection speed of the receiving liquid is 0.1-1.0mL / min; and the injection speed of the sample is 0.1-1.0mL / min.

[0026] Furthermore, the spacer liquid, receiving liquid, and sample enter and exit the sampling device through at least one of a syringe pump and a peristaltic pump.

[0027] The specific electrodialysis process is as follows: the sample solution composed of nanoparticles and dissolved ions enters the sample channel composed of two dialysis membranes. The dialysis membrane only allows molecules / ions with a molecular weight smaller than the cutoff to pass through. Therefore, even if the nanoparticles undergo electromigration, they cannot pass through the dialysis membrane, thereby achieving the separation of nanoparticles and ions under electrodialysis.

[0028] In order to reduce the impact of oxygen and hydrogen generated by the electrodes on the receiving liquid channel and the sample channel, an isolation liquid channel is also present between the ion exchange membrane and the electrode; after the sample passes through the sample channel, the anions and cations in it are concentrated in the receiving liquid channel and carried away by the receiving liquid; only uncharged neutral particles and nanoparticles that cannot pass through the dialysis membrane remain in the sample, realizing online removal of dissolved ions.

[0029] The beneficial effects of the present invention are:

[0030] The present invention discloses an electrodialysis single-particle inductively coupled plasma mass spectrometry sampling device, which comprises an upper clamping plate, a lower clamping plate, an anode electrode, a first gasket, a cation exchange membrane, an upper isolation liquid channel, a second gasket, an upper dialysis membrane, an upper receiving liquid channel, a third gasket, a lower dialysis membrane, a sample channel, a fourth gasket, an anion exchange membrane, a lower receiving liquid channel, a fifth gasket, a cathode electrode, and a lower isolation liquid channel. Under the action of an electric field, after a test sample passes through the sample channel, cations and anions respectively enter the receiving liquid channel composed of a dialysis membrane and an ion exchange membrane and are carried away by the receiving liquid; only uncharged neutral particles and nanoparticles that cannot pass through the dialysis membrane remain in the sample, thereby achieving online removal of dissolved ions, quickly reducing background dissolved ions and other interfering molecules in the sample, reducing interference in mass spectrometry detection, and enabling mass spectrometry detection to have a lower particle size detection limit. The device has excellent prospects for promotion and application.

[0031] 1. Using flow injection technology, the sample throughput is large and the analysis speed is fast;

[0032] 2. It can quickly reduce the background dissolved ions and other interfering molecules in the sample and reduce the interference of mass spectrometry detection;

[0033] 3. The present invention makes it easier to distinguish ion signals from particle signals during data analysis, thereby having a lower particle size detection limit.

[0034] 4. The method for removing metal ions provided by the present invention is highly versatile and can remove both cationic and anionic metal ions. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. The drawings described below are merely embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0036] Figure 1 This is a disassembly diagram of the sampling device;

[0037] 1 is an upper clamping plate; 2 is gasket one; 3 is a cation exchange membrane; 4 is gasket two; 5 is an upper dialysis membrane; 6 is gasket three; 7 is a lower dialysis membrane; 8 is gasket four; 9 is an anion exchange membrane; 10 is gasket five; 11 is a lower clamping plate; 12 is an anode electrode; 13 is a cathode electrode; 14 is a sample channel; 15 is an upper receiving liquid channel; 16 is an upper spacer liquid channel; 17 is a lower receiving liquid channel;

[0038] Figure 2 Graph showing the detection results of silver nanoparticles after the sample has not passed through the electrodialysis sampling device of the present invention;

[0039] Figure 3 This is a diagram showing the detection results of silver nanoparticles after the sample passes through the electrodialysis sampling device of the present invention. DETAILED DESCRIPTION

[0040] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0041] It should be noted that the following detailed descriptions are exemplary and intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the present invention belongs.

[0042] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present invention. As used herein, unless the context clearly indicates otherwise, the singular form is intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, they indicate the presence of features, steps, operations and / or combinations thereof.

[0043] Example 1:

[0044] like Figure 1 As shown, an electrodialysis single particle inductively coupled plasma mass spectrometry sampling device comprises:

[0045] From top to bottom or bottom to top, they are: upper clamping piece, anode electrode, gasket one, cation exchange membrane, gasket two, upper dialysis membrane, gasket three, lower dialysis membrane, gasket four, anion exchange membrane, gasket five, cathode electrode, lower clamping piece; the upper clamping piece and the lower clamping piece are used to clamp the sample injection device and seal the components;

[0046] The middle of the gasket is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket, the anode electrode and the cation exchange membrane are clamped to form an upper isolation liquid channel;

[0047] The middle of the second gasket is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the second gasket, the cation exchange membrane and the upper dialysis membrane are clamped to form an upper receiving liquid channel;

[0048] The middle of the gasket three is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket three, the upper dialysis membrane and the lower dialysis membrane are clamped to form a sample channel;

[0049] The middle of the gasket 4 is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket 4, the lower dialysis membrane and the anion exchange membrane are clamped to form a lower receiving liquid channel;

[0050] The middle of the gasket 5 is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket 5, the anion exchange membrane and the cathode electrode are clamped to form a lower isolation liquid channel;

[0051] The upper spacer liquid passes through the upper clamping piece and enters the upper spacer liquid channel to form an upper spacer liquid inlet channel; after the upper spacer liquid flows to the other end of the upper spacer liquid channel, it is discharged from the injection device through the other end of the upper clamping piece to form an upper spacer liquid outlet channel;

[0052] The upper receiving liquid passes through the upper clamping sheet, the first gasket, and the cation exchange membrane in sequence, and enters the upper receiving liquid channel to form an upper receiving liquid inlet channel; after the upper receiving liquid flows to the other end of the upper receiving liquid channel, it passes through the cation exchange membrane, the first gasket, and the other end of the upper clamping sheet and is discharged from the injection device to form an upper receiving liquid outlet channel;

[0053] The sample passes through the upper clamping sheet, gasket 1, cation exchange membrane, gasket 2, and upper dialysis membrane in sequence into the sample channel to form a sample inlet channel; after the sample flows to the other end of the sample channel, it passes through the upper dialysis membrane, gasket 2, cation exchange membrane, gasket 1, and the other end of the upper clamping sheet to exit the sample injection device to form a sample outlet channel;

[0054] The lower receiving liquid passes through the lower clamping sheet, the fifth gasket, and the anion exchange membrane in sequence, and enters the lower receiving liquid channel to form a lower receiving liquid inlet channel; after the lower receiving liquid flows to the other end of the lower receiving liquid channel, it passes through the anion exchange membrane, the fifth gasket, and the other end of the lower clamping sheet to discharge the sample injection device to form a lower receiving liquid outlet channel;

[0055] The lower isolation liquid passes through the lower clamping piece and enters the lower isolation liquid channel to form a lower isolation liquid inlet channel; after the lower isolation liquid flows to the other end of the lower isolation liquid channel, it is discharged from the sampling device through the other end of the lower clamping piece to form a lower isolation liquid outlet channel.

[0056] The cathode electrode and the anode electrode are metal titanium electrodes.

[0057] The upper and lower clamping plates are made of PMMA;

[0058] The material of the gasket is silicone;

[0059] The cation exchange membrane is a polymer cation exchange membrane;

[0060] The dialysis membrane is a cellulose acetate membrane;

[0061] The anion exchange membrane is a polymer anion exchange membrane.

[0062] The isolation liquid is composed of water. The receiving liquid is composed of water.

[0063] The voltage between the positive and negative electrodes of the sample injection device is 20V; the injection speed of the spacer liquid is 0.3mL / min; the injection speed of the receiving liquid is 0.3mL / min; the injection speed of the sample is 0.3mL / min;

[0064] The spacer liquid, receiving liquid and sample enter and exit the sampling device through a syringe pump.

[0065] The specific electrodialysis process is as follows: the sample solution composed of nanoparticles and dissolved ions enters the sample channel composed of two dialysis membranes. The dialysis membrane only allows molecules / ions with a molecular weight smaller than the cutoff to pass through. Therefore, even if the nanoparticles undergo electromigration, they cannot pass through the dialysis membrane, thereby achieving the separation of nanoparticles and ions under electrodialysis.

[0066] In order to reduce the impact of oxygen and hydrogen generated by the electrodes on the receiving liquid channel and the sample channel, an isolation liquid channel is also present between the ion exchange membrane and the electrode; after the sample passes through the sample channel, the anions and cations in it are concentrated in the receiving liquid channel and carried away by the receiving liquid; only uncharged neutral particles and nanoparticles that cannot pass through the dialysis membrane remain in the sample, realizing online removal of dissolved ions.

[0067] Example 2:

[0068] Utilize the sample introduction device in Example 1:

[0069] First, silver nanoparticle solution (50 nm, 0.1 mg / mL, solvent water) was injected into the sample channel at a rate of 0.3 mL / min via a syringe pump;

[0070] Second, push the syringe pump to inject deionized water into the anode and cathode receiving liquid channels at a rate of 0.3 mL / min;

[0071] 3. Driven by the syringe pump, deionized water is introduced into the isolation liquid channel at a rate of 0.3 mL / min;

[0072] Fourth, under the action of an electric field (voltage 25V), cations and anions flow in two directions into the upper and lower receiving liquid channels composed of the dialysis membrane and ion exchange membrane, respectively. To reduce the impact of oxygen and hydrogen generated by the electrodes on the receiving and sample channels, a spacer liquid channel (water) is placed between the ion exchange membrane and the electrodes. After the sample passes through the sample channel, the cations and anions in it are concentrated in the receiving channel and carried away by the receiving liquid. Only uncharged neutral particles and nanoparticles that cannot pass through the dialysis membrane remain in the sample, achieving online removal of dissolved ions.

[0073] 5. The purified sample solution is coupled with inductively coupled plasma mass spectrometry to obtain the time-resolved signal of silver. Figure 2 As shown in Figure 2, the silver nanoparticle signal without electrodialysis device is suppressed by the high background silver ion signal, as shown in Figure 2. Figure 3 As shown in the figure, the silver ion signal of the sample with the electrodialysis device is reduced, the number of silver nanoparticle signals is increased, and the particle size resolution is significantly improved.

[0074] In summary, the present invention discloses an electrodialysis single-particle inductively coupled plasma mass spectrometry sampling device, which consists of an upper clamping plate, a lower clamping plate, an anode electrode, a gasket one, a cation exchange membrane, an upper isolation liquid channel, a gasket two, an upper dialysis membrane, an upper receiving liquid channel, a gasket three, a lower dialysis membrane, a sample channel, a gasket four, an anion exchange membrane, a lower receiving liquid channel, a gasket five, a cathode electrode, and a lower isolation liquid channel. Under the action of an electric field, after the test sample passes through the sample channel, the cations and anions respectively enter the receiving liquid channel composed of the dialysis membrane and the ion exchange membrane and are carried away by the receiving liquid; only uncharged neutral particles and nanoparticles that cannot pass through the dialysis membrane remain in the sample, thereby realizing online removal of dissolved ions, quickly reducing background dissolved ions and other interfering molecules in the sample, reducing interference in mass spectrometry detection, and making the mass spectrometry detection have a lower particle size detection limit, which has excellent prospects for promotion and application.

[0075] In the description of the present invention, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0076] At this point, those skilled in the art will recognize that, although the embodiments of the present invention have been shown and described in detail herein, many other variations or modifications consistent with the principles of the present invention may be directly determined or derived from the disclosure of the present invention without departing from the spirit and scope of the present invention. Therefore, the scope of the present invention should be understood and deemed to cover all such other variations or modifications.

Claims

1. An electrodialysis single particle inductively coupled plasma mass spectrometry sampling device, characterized in that: The device comprises: From top to bottom or from bottom to top, they are: upper clamping piece, anode electrode, gasket one, cation exchange membrane, gasket two, upper dialysis membrane, gasket three, lower dialysis membrane, gasket four, anion exchange membrane, gasket five, cathode electrode, lower clamping piece; the sample injection device is clamped and sealed by the upper clamping piece and the lower clamping piece; The middle of the gasket is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket, the anode electrode and the cation exchange membrane are clamped to form an upper isolation liquid channel; The middle of the second gasket is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the second gasket, the cation exchange membrane and the upper dialysis membrane are clamped to form an upper receiving liquid channel; The middle of the gasket three is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket three, the upper dialysis membrane and the lower dialysis membrane are clamped to form a sample channel; The middle of the gasket 4 is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket 4, the lower dialysis membrane and the anion exchange membrane are clamped to form a lower receiving liquid channel; The middle of the gasket 5 is hollowed out to form a hollow portion penetrating from top to bottom, and the hollow portion of the gasket 5, the anion exchange membrane and the cathode electrode are clamped to form a lower isolation liquid channel; The upper spacer liquid passes through the upper clamping piece and enters the upper spacer liquid channel to form an upper spacer liquid inlet channel; after the upper spacer liquid flows to the other end of the upper spacer liquid channel, it is discharged from the injection device through the other end of the upper clamping piece to form an upper spacer liquid outlet channel; The upper receiving liquid passes through the upper clamping sheet, the first gasket, and the cation exchange membrane in sequence, and enters the upper receiving liquid channel to form an upper receiving liquid inlet channel; after the upper receiving liquid flows to the other end of the upper receiving liquid channel, it passes through the cation exchange membrane, the first gasket, and the other end of the upper clamping sheet and is discharged from the injection device to form an upper receiving liquid outlet channel; The sample passes through the upper clamping sheet, gasket 1, cation exchange membrane, gasket 2, and upper dialysis membrane in sequence into the sample channel to form a sample inlet channel; after the sample flows to the other end of the sample channel, it passes through the upper dialysis membrane, gasket 2, cation exchange membrane, gasket 1, and the other end of the upper clamping sheet to exit the sample injection device to form a sample outlet channel; The lower receiving liquid passes through the lower clamping sheet, the fifth gasket, and the anion exchange membrane in sequence, and enters the lower receiving liquid channel to form a lower receiving liquid inlet channel; after the lower receiving liquid flows to the other end of the lower receiving liquid channel, it passes through the anion exchange membrane, the fifth gasket, and the other end of the lower clamping sheet to discharge the sample injection device to form a lower receiving liquid outlet channel; The lower isolation liquid passes through the lower clamping piece and enters the lower isolation liquid channel to form a lower isolation liquid inlet channel; after the lower isolation liquid flows to the other end of the lower isolation liquid channel, it is discharged from the sampling device through the other end of the lower clamping piece to form a lower isolation liquid outlet channel.

2. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The cathode electrode and the anode electrode are metal titanium electrodes.

3. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The upper and lower clamping plates are made of polymethyl methacrylate (PMMA).

4. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The material of the gasket is silica gel.

5. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The cation exchange membrane includes a polymer ion exchange membrane, an inorganic ion exchange membrane and a composite ion exchange membrane.

6. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The dialysis membrane includes regenerated cellulose membrane, cellulose acetate membrane, cellulose substitute membrane and synthetic membrane.

7. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The anion exchange membrane includes a polymer ion exchange membrane, an inorganic ion exchange membrane and a composite ion exchange membrane.

8. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The isolation liquid is composed of water; the receiving liquid is composed of water.

9. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The voltage between the positive and negative electrodes of the injection device is 5-25V; the injection speed of the spacer liquid is 0.1-1.0mL / min; the injection speed of the receiving liquid is 0.1-1.0mL / min; and the injection speed of the sample is 0.1-1.0mL / min.

10. The electrodialysis single particle inductively coupled plasma mass spectrometry sampling device according to claim 1, characterized in that: The spacer liquid, receiving liquid and sample enter and exit the sampling device through at least one of a syringe pump and a peristaltic pump.

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