An oral antibacterial material and a preparation method and application thereof
By preparing oral antibacterial materials using CMCS-Mal, CMCS-NAC, and C16N-DCA as raw materials, and utilizing the charge reversal under acidic conditions and the water solubility of CMCS, the problem of existing antibacterial agents being unable to provide sustained antibacterial effects in the oral cavity is solved, achieving effective disruption of biofilms and long-term antibacterial effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BEIJING UNIV OF CHEM TECH
- Filing Date
- 2024-08-05
- Publication Date
- 2026-06-09
AI Technical Summary
Existing antibacterial agents cannot achieve sustained antibacterial effects in the oral cavity due to the rapid removal by saliva, making them difficult to effectively treat infectious diseases such as dental caries and periodontal disease caused by biofilms.
Oral antibacterial materials were prepared using CMCS-Mal, CMCS-NAC, and C16N-DCA as raw materials. By designing the acid-sensitive amphiphilic molecule C16N-DCA to reverse its charge in an acidic environment, the biomembrane framework was disrupted. The water solubility and pH sensitivity of CMCS were used to improve adhesion, forming a controllable adhesive material that forms a rapid gel.
It effectively disrupts biofilms in an acidic oral environment, providing long-term antibacterial effects, improving drug delivery efficiency and adhesion, and adapting to the treatment needs of oral microstructure.
Smart Images
Figure CN118903186B_ABST