Intelligent microfluidic chip and temperature field measurement and control and pressure field monitoring method thereof

Abstract

The application discloses an intelligent micro-fluidic chip with temperature field measurement and control and pressure field monitoring functions. The chip contains a reaction process detection unit for measuring the temperature field and pressure field changes of a reaction area in the chip and outputting the measurement results in the form of digital quantity; and a temperature control unit for realizing accurate control on the temperature field in the chip. In addition, the application also relates to a micro-fluidic chip temperature field measurement and control and pressure field monitoring method, through real-time monitoring of temperature and pressure values, establishment of the temperature field and the pressure field and combination of a machine learning model in a computer, calculation and prediction on key parameters and characteristics of a reaction process, accurate control on the temperature of a chemical reaction process in the micro-fluidic chip and pressure overrun alarm are realized. The intelligent micro-fluidic chip has the advantages of simple structure, convenient operation, high measurement precision, suitability for various chemical reaction processes, high temperature resistance, high pressure resistance, good wear resistance and corrosion resistance.

Description

Technical Field

[0001] This invention relates to the field of microchemical technology, and in particular to a smart microfluidic chip, as well as a method for measuring and controlling the temperature field and monitoring the pressure field within the smart microfluidic chip. Background Technology

[0002] Microfluidic chips are devices manufactured using microfabrication technology to enable highly efficient chemical reactions in channels ranging from micrometers to nanometers. Thanks to their high specific surface area and excellent heat and mass transfer properties, microfluidic chips have shown significant application potential in various fields such as chemical production, drug synthesis, and advanced materials preparation. This particular chip is suitable for a variety of chemical reaction processes, including sulfonation, nitration, and esterification.

[0003] Temperature is crucial to the performance of microfluidic chips because it directly affects the rate and efficiency of chemical reactions, as well as the flow characteristics of fluids and the purity of products. Among existing temperature measurement technologies, contact temperature measurement techniques, such as thermocouples, are unsuitable for internal measurement within microfluidic chips due to their large size. In cases of abnormal temperatures, these techniques struggle to accurately pinpoint the anomaly, hindering timely adjustments. Non-contact temperature measurement techniques, such as infrared thermometry, suffer from insufficient accuracy, failing to ensure the reaction system remains within a suitable temperature range, potentially leading to decreased product purity and yield. Regarding temperature control, external temperature control technologies, such as water bath heat exchange and hot / cold fluid heat exchange, while widely used, cannot achieve precise point-to-point temperature control and have slow control rates. Integrated heating technologies, such as integrated platinum heaters and metal-coated heaters, only provide heating; cooling requires external equipment, resulting in large reaction system volumes and high energy consumption. Electromagnetic radiation heating technologies, such as microwave heating and laser heating, can lead to uneven heating, creating hot spots and causing thermal damage to the equipment. In conclusion, none of these temperature measurement and control methods possess the capability for accurate and rapid temperature measurement and control, which may have an adverse impact on product quality.

[0004] During the use of microfluidic chips, problems such as coking may occur, leading to blockage of reaction channels and abnormally high pressure drops in the reaction region, affecting the normal operation of the microfluidic chip. Pressure detection technology can help operators detect and address these faults promptly, thus preventing production accidents. Current pressure detection technologies primarily focus on pressure detection in external delivery pipelines, such as using pressure sensors and flow meters to monitor the fluid pressure entering the microfluidic chip. However, these methods often overlook the influence of the internal pressure field of the microfluidic chip on the reaction process. In fact, local pressure differences within the microfluidic chip can affect fluid flow and mixing characteristics, thereby impacting the uniformity and efficiency of the reaction.

[0005] Therefore, researching and developing a novel microfluidic chip to achieve real-time detection and control of the temperature field distribution and changes inside the microfluidic chip, as well as real-time monitoring of the pressure field distribution and changes inside the chip, is of great significance for accurately predicting and controlling micro-reaction processes. Summary of the Invention

[0006] To overcome the limitations of existing microfluidic chips in rapid temperature and pressure measurement, and the technical challenge of accurately reflecting the internal temperature and pressure fields of the chip and precisely controlling the internal temperature field, the first objective of this invention is to provide an intelligent microfluidic chip.

[0007] To achieve the above objectives, the present invention provides the following technical solution.

[0008] A smart microfluidic chip is characterized in that it contains a reaction process detection unit, which consists of a temperature sensor array and a pressure sensor array, respectively used to monitor the temperature field and pressure field changes in the reaction region within the chip, and output the measurement results in digital form; the temperature sensor array and pressure sensor array support online programming during device operation and can be updated in response to external signal interruptions.

[0009] Furthermore, the temperature sensor array and the pressure sensor array are integrated on a first printed circuit board; the first printed circuit board receives data from the temperature sensor array and the pressure sensor array and transmits it to an external control system to achieve real-time communication with the external control system.

[0010] Furthermore, the temperature field change data is output in digital form. After being processed by the first printed circuit board, it is transmitted to the external control system in real time via the bus, thereby obtaining the temperature field information within the reaction area. The pressure field change data is also output in digital form. After being exported by the first printed circuit board, it communicates with the external control system in real time via the bus.

[0011] Furthermore, the intelligent microfluidic chip also includes a temperature control unit; the temperature control unit consists of a Peltier element array, a control circuit, and a driving device; wherein, the Peltier element array and the driving device are integrated on a second printed circuit board, and the second printed circuit board outputs a PWM signal according to a PID control algorithm to enable the driving module at regular intervals to drive the Peltier element array to work; the driving device has feedback detection and overheat self-shutdown functions, uses the PWM signal to control the output power of the Peltier element array, and outputs a temperature adjustment signal through the control circuit, thereby realizing the control of the internal temperature field of the microfluidic chip.

[0012] Furthermore, the structure of the intelligent microfluidic chip, from top to bottom, consists of: a first printed circuit board, an upper sealing layer, a chip layer, a lower sealing layer, and a second printed circuit board; wherein, the first printed circuit board integrates a reaction process detection unit and a first microprocessor; the second printed circuit board houses a temperature control unit and a second microprocessor; the surface of the chip layer has micro-reaction channels, and the upper and lower sealing layers are used to seal the chip layer, thereby forming a micro-reaction region; the upper sealing layer has detection holes for temperature and pressure detection.

[0013] Furthermore, the chip layer is made of alumina ceramic, which is resistant to high temperatures, corrosion, and wear, and can meet the requirements of various chemical reactions, such as nitration and sulfonation.

[0014] Furthermore, both the first and second microprocessors are STM32 microcontrollers.

[0015] The intelligent microfluidic chip of this invention couples temperature and pressure monitoring functions, and features simple structure, ease of use, and high measurement accuracy.

[0016] The second objective of this invention is to provide a method for measuring and controlling the temperature field and monitoring the pressure field within a microfluidic chip, the specific technical solution of which is as follows.

[0017] A method for measuring and controlling the temperature field and monitoring the pressure field within a microfluidic chip includes the following steps:

[0018] After receiving the data transmitted by the temperature sensor array, the external control system uses a microprocessor to control the temperature control unit, which in turn precisely controls the temperature field of the microfluidic chip.

[0019] Pressure field data of the reaction area within the microfluidic chip is collected by a pressure sensor array and transmitted to the microprocessor in digital form. The microprocessor quickly analyzes the received pressure data. If the measured pressure value exceeds the preset safety range, the alarm function of the intelligent microfluidic chip will be automatically activated, and an alarm will be issued through a buzzer and LED indicator, and the alarm will be displayed on the interface in a flashing manner to remind the operator to take appropriate measures.

[0020] Furthermore, after the temperature field data and pressure field data are transmitted to the external control system, their status is displayed using a human-machine interface developed using the Python programming language.

[0021] Furthermore, the human-machine interface has the following functions: real-time monitoring and display of temperature and pressure field changes within the intelligent microfluidic chip; allowing users to set target values ​​for the temperature control unit; adjusting pressure alarm thresholds; automatically activating the alarm system when the pressure exceeds the safety limit and flashing the alarm on the interface to alert the operator; using the established temperature and pressure field model combined with computer machine learning technology to predict the flow pattern of the fluid under the model, thereby conducting in-depth prediction and analysis of the products of the microfluidic chip; and automatically generating and outputting detailed reports based on the collected data.

[0022] The intelligent microfluidic chip of this invention possesses high durability, capable of withstanding high temperature and high pressure environments, while exhibiting excellent wear resistance and corrosion resistance. Through connection with an external control system and the use of a high-performance STM32 microcontroller, temperature control commands are transmitted to the temperature control unit, enabling precise control of the microfluidic chip's temperature field. Simultaneously, based on pressure field data collected by a pressure sensor array, the system can alert operators via a human-machine interface to take appropriate pressure adjustment measures and provides an alarm function for abnormal pressure in the microreactor area. This not only improves the accurate prediction and precise control of chemical reaction processes within the microreactor but also significantly enhances the application potential of microfluidic chips in chemical production.

[0023] Compared with the prior art, the beneficial technical effects achieved by the present invention are as follows:

[0024] (1) The intelligent microfluidic chip of the present invention integrates real-time temperature and pressure monitoring functions, supports online programming during device operation, and can update the programming in response to external signal interruptions. This invention overcomes the limitations of existing microfluidic chips in rapid temperature and pressure measurement, and improves the monitoring and control capabilities of micro-reaction processes. The chip has the characteristics of simple structure, convenient operation, and high measurement accuracy.

[0025] (2) The intelligent microfluidic chip of the present invention is made of alumina ceramic material. Due to the excellent thermal properties of alumina ceramic material, such as high melting point, good high-temperature chemical stability, low coefficient of linear expansion, and good dimensional stability, the intelligent microfluidic chip of the present invention exhibits excellent high-temperature resistance, corrosion resistance, and wear resistance. This allows it to meet the requirements of various chemical reactions, including nitration, sulfonation, and esterification. In addition, alumina ceramic material naturally has compressive and bending resistance, which makes the intelligent microfluidic chip of the present invention also have the advantages of high pressure resistance, non-deformation, stable operation, and long service life.

[0026] (3) Compared with traditional microfluidic chips, this invention can not only measure the temperature and pressure fields inside the microfluidic chip, but also adds functions such as temperature control, pressure alarm, parameter calculation, product prediction, and flow pattern discrimination. The integration of these functions enables the system to detect problems in a timely manner and take corresponding measures, effectively preventing damage to reaction equipment and potential safety accidents. Attached Figure Description

[0027] Figure 1 This is a top exploded view of the components of the intelligent microfluidic chip of the present invention;

[0028] Figure 2 This is an exploded view of the components of this microfluidic chip from below;

[0029] Figure 3 for Figure 1 , Figure 2 Circuit connection diagram of medium temperature sensor array;

[0030] Figure 4 for Figure 1 , Figure 2 Circuit connection diagram of medium pressure sensor array;

[0031] Figure 1 , Figure 2 In the diagram, 1-first printed circuit board; 2-upper sealing layer; 3-chip layer; 4-lower sealing layer; 5-second printed circuit board; 6-Peltier element array; 7-temperature sensor array; 8-pressure sensor array. Detailed Implementation

[0032] The specific structure and working principle of the intelligent microfluidic chip of the present invention will be described in detail below with reference to the accompanying drawings and some preferred embodiments.

[0033] It should be noted that the directional indicators (such as up, down, left, right, front, back, etc.) involved in the embodiments of the present invention are only used to explain the relative positional relationship or specific posture of the components in the intelligent micro-flow control chip of the present invention under a certain specific posture (as shown in the figure). If the relative position or specific posture changes, the directional indicator will also change accordingly.

[0034] Furthermore, the terms "first," "second," etc., used in the embodiments of the present invention are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature. Additionally, the technical solutions of the various embodiments of the present invention can be combined with each other, but only on the basis of being achievable by those skilled in the art. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by the present invention.

[0035] like Figure 1 , 2 As shown, the intelligent microfluidic chip of the present invention comprises a first printed circuit board 1, an upper sealing layer 2, a chip layer 3, a lower sealing layer 4, a second printed circuit board 5, a Peltier element array 6, a temperature sensor array 7, and a pressure sensor array 8. The temperature sensor array 7 and the pressure sensor array 8 are integrated on the printed circuit board 1; the Peltier element array 6 is integrated on the second printed circuit board 5; and the upper surface of the upper sealing layer 2 has detection holes for detecting temperature and pressure.

[0036] Figure 3 , Figure 4 They are respectively Figure 1 , Figure 2 Circuit connection diagrams for the temperature sensor array and the pressure sensor array. Figure 3 In this circuit, the sensor's data pin DQ is connected to any pin of the microprocessor that has GPIO functionality. A 4.7K pull-up resistor needs to be connected between them to maintain the stability of the single-bus communication and ensure that the single bus remains at a high level during idle time. The sensor's VCC pin is connected to the VCC3.3V pin of the microprocessor's power supply circuit, and the sensor's GND pin is grounded. Figure 4In this configuration, the sensor's VDDIO pin is connected to the microprocessor's VDDIO pin, the sensor's serial clock input SCK pin is connected to the microprocessor's SCK pin, and the sensor's VSS pin is grounded. A 100nF decoupling capacitor is added between the sensor's VDDIO and VSS pins to improve system stability and signal quality. The sensor's serial data input pin SDI and serial data output pin SDO are connected to the microprocessor's SDI and SDO pins, respectively. The sensor's chip select pin CSB is connected to the microprocessor's CSB chip select pin. The sensor's INT pin is connected to the microprocessor's INT pin or any pin with GPIO function, or it may not be connected. The sensor's two VSS pins are grounded, and the sensor's analog power supply VDD pin is connected to the microprocessor's VDD pin. A 100nF decoupling capacitor is added between VDD and VSS to improve system stability and signal quality.

[0037] As a specific embodiment, chip layer 3 is made of alumina ceramic material; it is 160mm long, 90mm wide, and 2mm thick; micro-reaction channels with a width of 2mm and a depth of 2mm are processed on the microfluidic chip layer, some of which have a sudden expansion structure to enhance mass transfer; and three hole structures A, B, and C are provided on the upper surface of chip layer 3; where hole A is the liquid phase raw material inlet, hole B is the gas phase raw material inlet, and hole C is the product outlet.

[0038] As a specific embodiment, the first printed circuit board 1 is 160mm long, 90mm wide, and 0.41mm thick; a total of 20 temperature sensors 7 and 16 pressure sensors 8 are integrated on it.

[0039] As a specific embodiment, the upper sealing plate 2 is made of alumina material; it is 160mm long, 90mm wide, and 1mm thick; it has temperature detection holes and pressure detection holes, the temperature detection holes are 3mm×3mm×0.5mm, and the pressure detection holes are 2mm×2mm×1mm. The temperature sensor array 7 and the pressure sensor array 8 detect the corresponding data in the detection holes; the temperature sensor array 7 and the pressure sensor array 8 are fixed in the detection holes using thermally conductive adhesive.

[0040] As a specific embodiment, the lower sealing plate is made of alumina material; it is 160mm long, 90mm wide, and 2mm thick.

[0041] As a specific embodiment, the second printed circuit board 5 is 160mm long, 90mm wide, and 0.41mm thick; a Peltier element array 6 consisting of 37 Peltier elements is integrated on it.

[0042] In the intelligent microfluidic chip of the present invention, the temperature sensor array 7 has online programming and interrupt programming functions. It is fixed in the temperature detection hole of the upper sealing layer 2 and is used to measure the internal temperature field of the microfluidic chip and output the data in digital form. The first printed circuit board 1 further leads out the data output by the temperature sensor array 7 and transmits the data to the computer host through a single bus, thereby realizing the communication function with the computer host.

[0043] In the intelligent microfluidic chip of the present invention, the pressure sensor array 8 has online programming and interrupt programming functions. It is fixed in the pressure detection hole of the upper sealing layer 2 to realize the measurement of the internal pressure field of the microfluidic chip and output the data in digital form. The first printed circuit board 1 further leads out the data output by the pressure sensor array and transmits the data to the computer host through the SPI bus, thereby realizing the communication function with the computer host.

[0044] In the intelligent microfluidic chip of the present invention, the Peltier element array 6 is integrated on the second printed circuit board 5 and is in close contact with the lower sealing layer 4; the computer host outputs a PWM signal using a PID control algorithm based on the received temperature data, and continuously adjusts the operation of the Peltier element array 6, thereby controlling the temperature field distribution inside the microfluidic chip.

[0045] The intelligent microfluidic chip provided by this invention has a 12-bit digital output for temperature data, a resolution of 0.0625℃, a temperature measurement range of -55℃ to +125℃, and a temperature measurement accuracy of ±0.5℃; and a 24-bit digital output for pressure data, a resolution of 0.016Pa, a pressure measurement range of 30kPa to 125kPa, and a pressure measurement accuracy of ±50Pa.

[0046] As a further preferred embodiment, this invention utilizes the aforementioned intelligent microfluidic chip in conjunction with a computer host to develop a method for temperature field measurement and control and pressure field monitoring within the microfluidic chip. Specifically, the temperature field measurement and control method involves setting temperature control parameters and safety range values ​​within the micro-reaction region of the microfluidic chip via a human-machine interface, and monitoring the temperature values ​​in real time. The microfluidic chip automatically collects temperature data from different locations within the micro-reaction region and transmits it to the computer host in digital form. Upon receiving the data signal, the computer host transmits temperature control commands to the temperature control unit via a microprocessor, thereby achieving precise control of the temperature field within the microfluidic chip.

[0047] The specific implementation of the pressure field monitoring method involves setting the pressure safety range within the micro-reaction region of the microfluidic chip via a human-machine interface (HMI) and monitoring the pressure value in real time. The microfluidic chip automatically collects pressure data from different locations within the micro-reaction region and transmits it to the microprocessor in digital form. The microprocessor quickly analyzes the received pressure data. If the detected pressure value exceeds the preset safety range, the alarm function of the intelligent microfluidic chip is automatically activated, triggering an alarm via a buzzer and LED indicator. Simultaneously, the alarm information is displayed on the HMI to remind the operator to take appropriate measures.

[0048] In a preferred embodiment of the present invention, the microprocessor is an STM32 microcontroller. STM32 represents a series of 32-bit microcontrollers with an ARM Cortex-M core, encompassing multiple models such as STM32L, STM32F0, STM32F105, and STM32F107. Those skilled in the art, combining the design principles of the STM32 platform, can re-optimize the functionality, memory, performance, and pin count of the intelligent microfluidic chip of the present invention by selecting appropriate product models, thereby meeting personalized application requirements with minimal hardware adjustments. For example, the models currently available on the market include: basic models: STM32F101R6, STM32F101C8, STM32F101R8, STM32F101V8, STM32F101RB, STM32F101VB; and enhanced models: STM32F103C8, STM32F103R8, STM32F103V8, STM32F103RB, STM32F103VB, STM32F103VE, STM32F103ZE, etc.

[0049] As a further preferred embodiment, the microfluidic chip temperature field measurement and control and pressure field monitoring method of the present invention, based on the basic functions of an intelligent microfluidic chip, combines it with a computer host, a human-machine interface system, a buzzer, LED indicators, and other technical means to develop a microfluidic chip temperature field measurement and control and pressure field monitoring method with pressure alarm function. Specifically, the microprocessor rapidly analyzes the received pressure data. If the measured pressure value exceeds the preset safety range, the pressure alarm function of the human-machine interface is automatically activated, and an alarm is issued through a buzzer and LED indicator. Simultaneously, alarm information is displayed on the human-machine interface to remind the operator to take appropriate measures.

[0050] The method of this invention can continuously monitor the temperature and pressure fields inside an intelligent microfluidic chip in real time and precisely control the temperature field. Furthermore, the intelligent microfluidic chip possesses high durability, able to withstand high temperature and high pressure environments, while exhibiting good wear resistance and corrosion resistance. Through connection to a computer host and employing a high-performance STM32 microprocessor, temperature control commands are transmitted to the temperature control unit, achieving precise control of the microfluidic chip's temperature field. Simultaneously, based on pressure field data collected by a pressure sensor array, the system can alert operators via a human-machine interface to take appropriate pressure adjustment measures and has an alarm function for abnormal pressure in the microreactor area. This not only improves the accurate prediction and precise control of chemical reaction processes within the microreactor but also significantly enhances the application potential of microfluidic chips in chemical production.

[0051] Other matters not covered in this invention are common knowledge.

[0052] The above embodiments are only for illustrating the technical concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and implement it accordingly, but are not intended to limit the scope of protection of the present invention. All equivalent changes or modifications made in accordance with the spirit and essence of the present invention are covered within the scope of protection of the present invention.

Claims

1. A smart microfluidic chip, characterized in that, The intelligent microfluidic chip contains a reaction process detection unit, which consists of a temperature sensor array (7) and a pressure sensor array (8), respectively used to monitor the temperature field change and pressure field change in the reaction area within the chip, and output the measurement results in digital form. The temperature sensor array (7) and pressure sensor array (8) support online programming while the device is running and can be updated in response to external signal interruptions. The temperature sensor array (7) and pressure sensor array (8) are integrated on the first printed circuit board (1). The first printed circuit board (1) is used to receive the data output by the temperature sensor array (7) and pressure sensor array (8) and transmit it to the external control system to realize real-time communication with the external control system. The temperature field change data is output in digital form, processed by the first printed circuit board (1), and transmitted to the external control system in real time through the bus to obtain the temperature information in the reaction area. The pressure field change data is also output in digital form, exported by the first printed circuit board (1), and communicated with the external control system in real time through the bus. The intelligent microfluidic chip contains a temperature control unit; the temperature control unit consists of a Peltier element array (6), a control circuit, and a driving device; wherein, the Peltier element array (6) is integrated on a second printed circuit board (5), and the second printed circuit board (5) outputs a PWM signal according to a PID control algorithm to enable the driving module at a time to drive the Peltier element array (6) to work; the driving device has feedback detection and overheat self-shutdown functions, controls the output power of the Peltier element array (6) through the PWM signal, and controls the circuit to output a temperature adjustment signal to realize the control of the internal temperature field of the intelligent microfluidic chip; The structure of the intelligent microfluidic chip is as follows: a first printed circuit board (1), an upper sealing layer (2), a chip layer (3), a lower sealing layer (4), and a second printed circuit board (5); wherein, the first printed circuit board (1) integrates a reaction process detection unit and a first microprocessor; the second printed circuit board (5) is provided with a temperature control unit and a second microprocessor; wherein, the surface of the chip layer (3) is provided with a micro-reaction channel, and the upper sealing layer (2) and the lower sealing layer (4) are used to seal the chip layer (3) to form a micro-reaction region; the upper sealing layer (2) is provided with detection holes for detecting temperature field and pressure field.

2. The intelligent microfluidic chip as described in claim 1, characterized in that, The chip layer (3) is made of alumina ceramic; the first microprocessor and the second microprocessor are both STM32 microcontrollers.

3. A method for measuring and controlling the temperature field and monitoring the pressure field within a microfluidic chip, characterized in that, Temperature field data of the reaction area within the microfluidic chip is automatically collected by a temperature sensor array (7) and transmitted to an external control system in digital form; pressure field data of the reaction area within the microfluidic chip is collected by a pressure sensor array (8) and transmitted to a microprocessor in digital form; the microfluidic chip is an intelligent microfluidic chip as described in any one of claims 1 or 2.

4. The method for temperature field measurement and control and pressure field monitoring within a microfluidic chip as described in claim 3, characterized in that, After receiving the data transmitted by the temperature sensor array (7), the external control system transmits the temperature control command to the temperature control unit through the first microprocessor. The temperature control unit then precisely controls the temperature field of the microfluidic chip. The pressure field data of the reaction area inside the microfluidic chip is collected by the pressure sensor array (8) and transmitted to the second microprocessor in the form of digital quantity. The second microprocessor quickly analyzes the received pressure data. If the measured pressure value exceeds the preset safety range, the alarm function of the intelligent microfluidic chip will be automatically activated. An alarm will be issued through a buzzer and LED indicator, and the operator will be reminded to take corresponding measures by flashing on the interface.

5. The method for temperature field measurement and control and pressure field monitoring within a microfluidic chip as described in claim 4, characterized in that, After the temperature and pressure field data are transmitted to the external control system, their status is displayed using a human-machine interface developed using the Python programming language.

6. The method for temperature field measurement and control and pressure field monitoring within a microfluidic chip as described in claim 5, characterized in that, The human-machine interface has the following functions: real-time monitoring and display of temperature and pressure field changes within the intelligent microfluidic chip; allowing users to set target values ​​for the temperature control unit; adjusting pressure alarm thresholds; automatically activating the alarm system when the pressure exceeds the safety limit and flashing the alarm on the interface to alert the operator; using the established temperature and pressure field model combined with computer machine learning technology to predict the flow pattern of the fluid under the model, thereby enabling in-depth prediction and analysis of the products of the microfluidic chip; and automatically generating and outputting detailed reports based on the collected data.

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