A cultivation method for rapid growth of milk thistle

By using the growth regulators gibberellic acid and aminoethyl ester aqueous solution in milk thistle cultivation, the milk thistle can be promoted to quickly enter the bolting stage from the rosette stage, which solves the problem of prolonged growth cycle caused by insufficient sunlight in southern regions and achieves high-efficiency growth and high yield.

CN118923445BActive Publication Date: 2026-03-10TONGLIAO ACADEMY OF AGRICULTURE & ANIMAL HUSBANDRY SCIENCE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-08-22
Publication Date
2026-03-10

AI Technical Summary

Technical Problem

In southern regions, milk thistles are unable to enter the bolting stage due to insufficient sunlight, resulting in a prolonged growth cycle and an inability to complete the full growth process, which affects yield and quality.

Method used

The auxin regulation method was adopted, and gibberellic acid and amino acid ester aqueous solution were used for foliar spraying to promote milk thistle to quickly enter the bolting stage from the rosette stage, and enhance the plant's absorption of water and fertilizer and growth and development.

Benefits of technology

It significantly shortens the growth cycle of milk thistle, increases yield and efficacy, reduces labor costs, and meets the market demand for high-efficiency, high-quality Chinese medicinal materials.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention belongs to the technical field of traditional Chinese medicine cultivation, specifically relating to a method for rapidly cultivating milk thistle. By regulating the milk thistle plant with auxin, the photosynthetic rate is increased, enabling it to quickly break through the rosette stage and enter the bolting stage. This enhances the plant's absorption of water and fertilizer, promoting its growth and development, allowing milk thistle to complete a full growth cycle in Hainan Province. A reagent preparation device specifically designed for this rapid milk thistle cultivation method is also provided, facilitating the aforementioned experiments and offering highly portable operation. This cultivation method significantly shortens the milk thistle's growth cycle, increases yield and efficacy, while reducing labor costs and environmental impact. Through scientific management and technological application, this method can yield high-quality milk thistle products in a shorter time, meeting the market demand for high-efficiency, high-quality traditional Chinese medicine.
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Description

Technical Field

[0001] This invention belongs to the technical field of Chinese medicinal herb cultivation, specifically relating to a cultivation method for rapid growth of milk thistle. Background Technology

[0002] Milk thistle ( Silybum marianum Milk thistle (L.) Gaertn., also known as water pheasant, is an annual to biennial herb belonging to the genus *Silybuamn* in the family Asteraceae. It is a type of traditional Chinese medicine used in northern China, possessing properties of clearing heat and dampness, soothing the liver and gallbladder. It is effective in treating acute and chronic hepatitis, cirrhosis, fatty liver, cholelithiasis, and cholangitis. Its active ingredient, silymarin, is one of the flavonoid extracts with the highest market share globally. Due to the favorable market conditions and high seasonal profits of milk thistle in recent years, research on milk thistle cultivation techniques and market demand have gradually increased, creating an urgent need to improve the yield and quality of milk thistle cultivation. Therefore, to accelerate the breeding of milk thistle varieties, the milk thistle breeding and cultivation technology research project team undertaken by the Tongliao Municipal Agricultural and Animal Husbandry Research Institute began a special southern breeding and generation-enhancing project for milk thistle in Sanya City, Hainan Province, starting in the winter of 2021.

[0003] Milk thistle is a northern variety, and its growth can be divided into seedling stage, rosette stage, bolting and budding stage, flowering and fruiting stage, and withering stage. Only after the plant enters the bolting stage from the rosette stage can it complete the subsequent flowering, fruiting, and withering processes. Northern regions have an average of over 13 hours of sunshine per day, classifying them as long-day areas, providing sufficient light for the entire growth process of milk thistle from emergence to withering. However, in Sanya City, Hainan Province, the average daily sunshine duration is less than 12 hours. Due to insufficient light, once the milk thistle enters the rosette stage, it remains in a low, creeping growth state with large leaves and thick stems, failing to enter the bolting stage and ultimately withering, thus failing to complete a full growth cycle. By utilizing modern high-tech methods to regulate the growth hormones in milk thistle plants, the photosynthetic rate can be increased, allowing them to quickly transition from the rosette stage to the bolting stage. This enhances the plant's absorption of water and fertilizer, promoting growth and development, and enabling milk thistle to complete a full growth cycle in Hainan Province. Using the same technology in northern regions, auxin regulation can similarly shorten the time from the rosette stage to the bolting stage by 15-20 days, thus promoting growth. Summary of the Invention

[0004] The purpose of this invention is to provide a method for cultivating milk thistle to promote rapid growth. This method involves regulating the growth of milk thistle plants with auxin to increase their photosynthetic rate, enabling them to quickly break through the rosette stage and enter the bolting stage. It also enhances the plant's absorption of water and fertilizer, promotes the growth and development of milk thistle plants, and thus promotes growth.

[0005] Another object of the present invention is to provide a reagent preparation device specifically for the above-mentioned cultivation method for rapid growth of milk thistle.

[0006] The above objective is achieved by the following technical solution:

[0007] A method for cultivating milk thistle for rapid growth, characterized by:

[0008] The growth and development of milk thistle can be regulated using auxin. The specific operation for auxin regulation is as follows:

[0009] (1) Selection of auxin reagent:

[0010] Reagent 1: A soluble solution of gibberellic acid with an active ingredient content of 4% by mass;

[0011] Reagent 2: Aqueous amino ester solution with an active ingredient content of 5% by mass;

[0012] (2) Operation time:

[0013] About one and a half months after sowing, no more than 7 days before and after, i.e., within the operation interval range of point (4) below, the application of auxin can be considered as the 0th starting cycle, which is about the rosette stage of milk thistle. At this time, auxin regulation begins; the regulation method is to spray the leaves with an aqueous solution of mixed growth regulator.

[0014] (3) Dosage ratio:

[0015] The aqueous solution content per acre is: 10 ml gibberellic acid and 5 ml amino acid esters;

[0016] (4) Operation method:

[0017] Each operation should be performed approximately every 7 days, and 3-5 operations should be performed depending on the situation. Generally, after three operations, the milk thistle plant will begin to bolt.

[0018] A pesticide preparation device specifically designed for the above-mentioned cultivation method for rapid growth of milk thistle, characterized in that:

[0019] The drug preparation device includes a support, a rotating shaft, branch pipes, a main pipe, and drug preparation units. Multiple drug preparation units are provided, and the number of branch pipes matches the number of drug preparation units. Specifically: the support serves as the basic structure for fixing, connecting, supporting, and protecting the rotating shaft, branch pipes, main pipe, and drug preparation units; the rotating shaft is fixed to the support and provides a rotating assembly connection for the drug preparation units; the branch pipes are fixed to the support and connect to the drug preparation units to establish a pipeline connection between the drug preparation units and the main pipe; the main pipe is fixed to the support and aggregates all branch pipes for unified output; and the drug preparation units are movably connected to the support via the rotating shaft and are used for drug preparation.

[0020] The dispensing unit includes a support arm and branch pipes. One end of the support arm is movably connected to a rotating shaft, and the other end is provided with multiple dispensing tubes. The top of each dispensing tube is an opening, and the openings of the dispensing tubes face upwards and are fixed side by side to the support arm. The middle of the branch pipe is movably connected to the rotating shaft. One end of the branch pipe is provided with a male connector, which is used to establish a pipeline connection between the branch pipe and the sub-pipe. The other end of the branch pipe is provided with multiple pipe plugs. The number of pipe plugs is consistent with the number of dispensing tubes, and the position of the pipe plugs corresponds one-to-one with the openings of the dispensing tubes.

[0021] One end of the branch pipe is equipped with a female connector that matches the male connector of the branch pipe. When the branch pipe is rotated so that the male connector at one end is close to the female connector of the branch pipe, the male connector and the female connector can be matched and connected, thus connecting the branch pipe and the branch pipe.

[0022] The plug of the branch pipe is hollow and fits the opening of the dispensing pipe. When the plug is fastened to the dispensing pipe, the hollow structure of the plug connects the branch pipe and the dispensing pipe.

[0023] The tube plug is made of rubber.

[0024] The male and / or female connectors are made of rubber.

[0025] The dispensing tube is equipped with a capacity system.

[0026] The plugs of the branch pipes and / or main pipes and / or sub-pipes are equipped with valves.

[0027] The dispensing unit is equipped with a control ring, which is located at the rotating shaft. The control ring is used to control, limit, and position the opening and closing angle between the support arm and the branch pipe.

[0028] The control loop includes an inner loop and an outer loop. The inner loop is fixedly connected to the branch pipe, and the outer loop is fixedly connected to the support arm. The inner loop and the outer loop are nested or overlapped and are coaxial.

[0029] The inner ring of the control ring is provided with a first damping gear, and the outer ring is provided with a first toothed disc that is adapted to the damping gear. The first damping gear and the first toothed disc are meshed and connected. The damping of the first damping gear is set to maintain the opening angle between the support arm and the support pipe under no external force.

[0030] The first damping gear is equipped with a locking pin, and the gear plate is equipped with multiple locking holes that can be adapted to the locking pin. After the locking pin is adapted to the locking holes and connected, the opening and closing angle between the support arm and the support pipe is limited and cannot be changed.

[0031] The control ring is provided with a side ring, which is fixedly connected to the bracket. The side ring is nested or overlapped with the outer ring and the two are coaxial. The outer ring is provided with a second damping gear, and the side ring is provided with a second toothed disc adapted to the second damping gear. The second damping gear is meshed and assembled with the second toothed disc. The damping of the second damping gear is set to maintain the opening angle between the support arm and the bracket under no external force.

[0032] The beneficial effects of this invention are: the cultivation method of this invention can significantly shorten the growth cycle of milk thistle, increase yield and efficacy, while reducing labor costs and environmental impact. Through scientific management and technological application, this method can obtain high-quality milk thistle products in a shorter time, meeting the market demand for high-efficiency, high-quality Chinese medicinal materials. Attached Figure Description

[0033] The attached image is as follows:

[0034] Figure 1 This is a schematic diagram of the pharmaceutical preparation device in Embodiment 3 of the present invention;

[0035] Figure 2 This is a schematic diagram of the drug dispensing unit in Embodiment 3 of the present invention;

[0036] Figure 3 This is a schematic diagram of the branch pipe and support arm of the drug dispensing unit in Embodiment 3 of the present invention in an unfolded state;

[0037] Figure 4 This is a schematic diagram showing the connection between the branch pipe and the sub-pipe of the dispensing unit in Embodiment 3 of the present invention;

[0038] Figure 5 This is a schematic diagram of the control loop structure in Embodiment 4 of the present invention, namely... Figure 2 A magnified schematic diagram of part A in the middle.

[0039] in:

[0040] 1. Drug preparation device, 2. Rotary shaft, 3. Branch pipe, 31. Female connector, 4. Main pipe, 5. Drug preparation unit, 51. Support arm, 52. Branch pipe, 53. Drug preparation pipe, 54. Male connector, 55. Pipe plug, 56. Orifice, 6. Control ring, 61. Inner ring, 62. Outer ring, 63. First damping wheel, 64. First gear disc. Detailed Implementation

[0041] First embodiment: Auxin treatment experiment.

[0042] To break the rosette shape of milk thistle, promote its growth and development, and shorten the fruit ripening time, multiple foliar sprays were applied using different types and concentrations of growth regulators, thereby increasing the yield of milk thistle seeds.

[0043] The Effects of Exogenous Hormones on the Growth and Development of Milk Thistle. Plant hormones promote plant growth and development. Depending on their function, they regulate various processes, from cell division and differentiation to germination, rooting, flowering, fruiting, and abscission, forming essential regulatory mechanisms for plant growth and development. Gibberellic acid is a broad-spectrum plant growth regulator that promotes crop growth and development, leading to earlier maturity, increased yield, and improved quality. Amino acid esters can regulate the activity and balance of various endogenous hormones within plants, increasing chlorophyll content and promoting photosynthesis, thereby accelerating plant growth. Many studies have shown that exogenous hormones can promote seed germination and growth of milk thistle. Liu Guangna et al. studied the effects of different concentrations of gibberellin and chlormequat chloride on silybin content and some physiological characteristics. The experiment found that when the gibberellin concentration was 200 mg / L, MDA, superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), chlorophyll content (Chl), milk thistle yield, and plant height reached the highest values. When the chlormequat chloride concentration was 100~300 mg / L, silybin, MDA, SOD, CAT, and Chl all showed an increasing trend, while POD, milk thistle yield, and plant height did not change significantly.

[0044] The timing of plant hormone application is also a crucial factor. Experiments show that auxin regulation should begin approximately one and a half months after sowing, when the milk thistle enters the rosette stage. Foliar spraying is the preferred method at this stage, as it allows for more even distribution of the auxin solution on the leaves, facilitating absorption. In practice, suitable temperature and humidity conditions should be maintained during spraying, as excessively low or high temperatures can negatively impact absorption efficiency. Furthermore, the concentration and frequency of spraying should be adjusted according to actual conditions to avoid the negative effects of overdose. Careful selection of appropriate auxin reagents and foliar spraying at suitable times and conditions can effectively promote the rapid growth of milk thistle. Simultaneously, monitoring environmental conditions and adjusting spraying strategies are essential to ensure optimal growth results.

[0045] I. Experimental Objective

[0046] To improve the photosynthetic rate of milk thistle, enhance the plant's absorption of water and fertilizer, increase fruit set rate, enlarge fruit size, and shorten fruit ripening time, a auxin regulation experiment was conducted on milk thistle plants using modern high-tech techniques under normal growth conditions to promote the growth and development of milk thistle, thereby increasing the yield of milk thistle seeds.

[0047] II. Test Materials

[0048] 1. The experimental variety was a conventional milk thistle.

[0049] 2. Three growth regulators were selected for the experiment. The first was an ethephon aqueous solution with an effective ingredient content of 40%; the second was a gibberellic acid soluble solution with an effective ingredient content of 4%; and the third was an aminoethyl ester aqueous solution with an effective ingredient content of 5%.

[0050] III. Test Methods

[0051] The experimental site was located at the milk thistle breeding and cultivation experimental base within the horticultural area of ​​the Dongshi Agricultural and Animal Husbandry Science Research Institute in Qianjiadian Town, Keerqin District, Tongliao City. Planting was done in ridges of varying widths: small ridges were 40cm wide with two rows sown, and large ridges were 100cm wide with a plant spacing of 30cm. Each experimental plot had a row length of 5m, a 1m wide walkway, and a 50cm narrow walkway, totaling 93 plots covering approximately 1 mu (0.067 hectares). At sowing, phorate granules were applied to the furrows for insect control. After sowing, the seeds were covered with 2.5-3cm of soil and then compacted. 15-20kg of compound fertilizer was applied per mu.

[0052] The experiment consisted of the following four treatments:

[0053] 1. Comparative experiment of different doses of a single reagent.

[0054] The experiment consisted of 9 blocks, as shown in Tables 1, 2 and 3.

[0055] The treatment method was foliar spraying, with each application spaced 7 days apart for 5 consecutive times, and repeated 3 times.

[0056] Table 1: Ethephon Treatment

[0057]

[0058] Table 2: Gibberellic acid treatment

[0059]

[0060] Table 3: Treatment with amino esters

[0061] .

[0062] By investigating the growth changes of plants in different phenological stages such as bolting, budding, flowering, maturity and harvest after auxin application in each block, the influence of different auxins on the reproductive growth of plants was analyzed and summarized, so as to determine which auxin plays a decisive role in the reproductive growth of plants and its optimal dosage ratio.

[0063] 2. Comparative experiment of three auxins combined with different dosages.

[0064] The experiment consisted of three blocks, as shown in Table 4.

[0065] The treatment method was foliar spraying, with each application spaced 7 days apart for 5 consecutive times, and repeated 3 times.

[0066] Table 4: Treatment with ethephon + gibberellic acid + aminoethyl ester

[0067] .

[0068] By investigating the growth changes of plants in different phenological stages such as bolting, budding, flowering, maturity and harvest after auxin application in various blocks, the optimal dosage ratio of the three auxins that significantly promotes the reproductive growth of plants was summarized.

[0069] 3. Comparative experiment on different dosages of gibberellic acid and aminoethyl ester, two auxins.

[0070] The experiment consisted of 9 blocks, as shown in Table 5.

[0071] The treatment method was foliar spraying, with each application spaced 7 days apart for 5 consecutive times, and repeated 3 times.

[0072] Table 5: Treatment with gibberellic acid and aminoethyl ester

[0073] .

[0074] By investigating the growth changes of plants in different phenological stages after being regulated by spraying two auxins in each block, the optimal dosage ratio was summarized.

[0075] 4. Comparative experiment on different phenological stages

[0076] The experiment consisted of four blocks, as shown in Table 6.

[0077] The treatment method was foliar spraying, with each application spaced 7 days apart for 5 consecutive times, and repeated 3 times.

[0078] Table 6: Treatments for different phenological stages

[0079] .

[0080] By investigating the growth changes of plants in different phenological stages such as bolting, budding, flowering, maturity and harvest after auxin application in various blocks, the optimal phenological period for auxin application that significantly promotes the reproductive growth of plants was identified.

[0081] 5. Control group.

[0082] Four communities were set up as the control group.

[0083] IV. Results Analysis

[0084] By comparing and observing the growth changes of plants in different phenological stages such as bolting, budding, flowering, maturity and harvest after auxin application in different treatment groups, as well as the actual yield of each plot after harvest, a set of optimal technical measures to promote the reproductive growth of milk thistle and increase the seed yield of milk thistle were finally summarized through statistical analysis.

[0085] Through observation, the overall growth status of the four treatments during the experiment was as follows:

[0086] 1. With a single reagent treatment, the experimental group plants showed signs of being shorter and thinner than the control group at different phenological stages, with smaller fruits, slightly later flowering, and delayed maturity.

[0087] 2. A comparative experiment of different dosages of three auxins was conducted. Compared with the control group, the experimental group plants showed normal growth, slightly larger fruits, flowering 3-5 days earlier, and earlier maturity at different phenological stages.

[0088] 3. A comparative experiment of different dosages of gibberellic acid and aminoethyl esters as two auxins showed that, compared with the control group, the experimental group plants were shorter and thinner, had smaller fruits, bloomed later, and matured later at different phenological stages.

[0089] 4. In the comparative experiment of three auxin combinations at different phenological stages, due to the higher temperature in the later stage, the milk thistle plants grew faster, and there was no significant difference between the experimental group and the control group.

[0090] V. Conclusion

[0091] By comparing and observing the growth changes of different treatment groups after auxin application during different phenological stages such as bolting, budding, flowering, maturity, and harvest, it was found that the growth of milk thistle plants in Experiments 1, 3, and 4 was not ideal, while the growth of milk thistle plants in Experiment 2 was good. This was the best technical measure, which can promote the reproductive growth of milk thistle and increase the yield of milk thistle seeds. However, the specific dosage needs to be confirmed by further detailed experimental operations.

[0092] The specific mechanisms by which gibberellic acid and aminoethyl esters promote the growth of milk thistle are mainly reflected in the following aspects:

[0093] Amino esters: Amino esters are broad-spectrum plant growth regulators. They increase the activity of plant peroxidase and nitrate reductase, thereby increasing chlorophyll content and accelerating photosynthesis, thus promoting plant cell division and elongation. In addition, amino esters can promote root development and regulate the balance of nutrients within the plant. They can also increase the content of chlorophyll, protein, and nucleic acids in the plant, improve photosynthetic efficiency, enhance the plant's absorption of water and fertilizer, and regulate the plant's water balance, thereby improving the plant's cold and drought resistance.

[0094] Gibberellic acid (GAA): GGAA is an endogenous tetracyclic diterpenoid plant hormone that plays a crucial role in mitigating abiotic stress-induced disturbances in plants by regulating various physiological, biochemical, and molecular processes. GGAA promotes cell division, cell elongation, and shoot germination, growth, and elongation, thereby enhancing crop vigor. It is one of the most widely used plant growth regulators both domestically and internationally, possessing broad-spectrum activity that promotes crop growth and development, leading to earlier maturity, increased yield, and improved quality.

[0095] Amino acid esters and gibberellic acid promote the growth of plants such as milk thistle through different mechanisms. Amino acid esters mainly promote plant growth by increasing photosynthetic efficiency, promoting cell division and elongation, and enhancing the plant's ability to absorb water and fertilizer. Gibberellic acid, on the other hand, promotes plant growth and development by regulating cell division and elongation, and promoting shoot germination and growth.

[0096] A comparison of the effects of 4% gibberellic acid soluble concentrate and 5% aminoethyl ester aqueous concentrate on the regulation of auxin in milk thistle.

[0097] 4% gibberellic acid soluble concentrate promotes crop cell division and growth, thus stimulating plant growth and development. It can stimulate cell elongation and, when used on grapes, jujubes, and mangoes, improves fruit set and increases fruit size, resulting in increased yield. Furthermore, gibberellic acid is considered one of the most widely used and effective of the six major plant growth regulators, promoting growth, protecting flowers and fruits, enlarging fruits, and inducing parthenocarpy. However, existing literature does not mention the effect of 5% aminoethyl ester aqueous solution on auxin regulation in milk thistle. The experiments and corresponding data analysis in this embodiment confirm the application effect of 5% aminoethyl ester aqueous solution on auxin regulation in milk thistle.

[0098] Currently, there is no direct evidence in existing literature that the use of auxin regulators can significantly accelerate the growth of milk thistle.

[0099] Second embodiment:

[0100] Based on the above embodiments, this embodiment further illustrates the method of using auxin and its mechanism.

[0101] Gibberellins are widely used in agricultural production because they can regulate the flowering time and number of flowers in plants. The gibberellin regulator in this embodiment refers to a class of substances with gibberellin as the main component and a plant hormone mechanism that can induce and control flowering. Its main function is to shorten the time required for plants to grow from the rosette stage to the flowering stage, thereby promoting the rapid growth of milk thistle.

[0102] The milk thistle cultivation method provided in this embodiment is as follows: After the milk thistle seedlings are transplanted and before flowering, spraying the seedlings with a gibberellic acid solution with a concentration of 20-40 mg / L can significantly shorten the time required for milk thistles to go from the rosette stage to the flowering stage.

[0103] Furthermore, a cultivation method is provided that uses aminoethyl esters as a regulator to shorten the time required for milk thistle to grow from the rosette stage to the flowering stage. This method includes: applying an appropriate amount of aminoethyl esters (0.2-0.5 mg / kg) to the soil during the milk thistle seedling and flower stalk formation stages after transplanting the seedlings and before flowering, followed by spraying the seedlings with the esters; and again, applying an appropriate amount of aminoethyl esters (0.2-0.5 mg / kg) to the soil during the milk thistle seedling and flower stalk formation stages after transplanting the seedlings and before flowering, followed by spraying the soil with the esters. The gibberellic acid solution and aminoethyl esters provided by the above milk thistle cultivation method both promote the growth of milk thistle and can significantly shorten the time required for milk thistle to grow from the rosette stage to the flowering stage.

[0104] Spraying gibberellic acid solution before sowing milk thistle seeds, before transplanting seedlings, and after transplanting until flowering can shorten the time from the rosette stage to the bolting stage of milk thistle, thereby promoting its growth.

[0105] Third embodiment:

[0106] Based on the above embodiments, this embodiment provides a pesticide preparation device specifically designed for the cultivation method of rapid growth of milk thistle. Its design is based on the fact that, during the experiments described in the above embodiments, it is necessary to frequently prepare pesticides in various proportions for large-scale implementation in experimental fields. Conventional pesticide preparation is cumbersome and inconvenient, and preparing pesticides in the experimental field environment differs significantly from the laboratory environment. For example, there is no experimental platform, materials are scattered, and operation is inconvenient. Furthermore, it is easily affected by various factors such as outdoor environment and crop obstruction, which may lead to errors in pesticide preparation. Therefore, this embodiment designs a pesticide preparation device suitable for the above environment to facilitate the above experiments; it is highly portable and easy to operate.

[0107] like Figure 1-4As shown, the drug dispensing device includes a support, a rotating shaft, branch pipes, a main pipe, and dispensing units. Multiple dispensing units are provided, and the number of branch pipes matches the number of dispensing units. The support serves as the basic structure for fixing, connecting, supporting, and protecting the rotating shaft, branch pipes, main pipe, and dispensing units. The support (not shown in the figure) can adopt a common structure from existing technology and will not be elaborated further. The rotating shaft is fixed to the support and provides a rotating assembly connection for the dispensing units. The branch pipes are fixed to the support and connect to the dispensing units to establish a pipeline connection between the dispensing units and the main pipe. The main pipe is fixed to the support and aggregates all branch pipes for unified output. The dispensing units are movably connected to the support via the rotating shaft and are used for dispensing the drug. Each dispensing unit includes a support arm and branch pipes, with one end of the support arm movably connected to... Multiple dispensing tubes are provided on the rotating shaft at one end, with the top of each tube having an opening. The dispensing tubes are fixed side-by-side on the support arm with the openings facing upwards. The middle of each branch tube is movably connected to the rotating shaft. One end of each branch tube has a male connector for establishing a connection between the branch tube and the sub-tube. The other end of each branch tube has multiple plugs, the number of which matches the number of dispensing tubes, and the positions of the plugs correspond one-to-one with the openings of the dispensing tubes. One end of each sub-tube has a female connector that matches the male connector of the branch tube. When the branch tube rotates so that its male connector approaches the female connector of the sub-tube, the male and female connectors can fit together and connect the branch tube and the sub-tube. The plugs of the branch tubes are hollow and fit the openings of the dispensing tubes. When the plugs are fastened onto the dispensing tubes, the hollow structure of the plugs connects the branch tube and the dispensing tube.

[0108] In use, the functions of the dispensing units can be flexibly allocated. For example, different concentrations or multiple sizes of the same reagent can be loaded into multiple dispensing tubes in the same dispensing unit. Multiple dispensing units can then be used to prepare various reagents of different concentrations or sizes, which can be selected and prepared as needed. Alternatively, multiple dispensing tubes in a dispensing unit can be filled with multiple reagents in a specific ratio, forming a single-component combination. Other dispensing units can be filled with reagents in different ratios. This allows the dispensing device to hold multiple reagents as needed, which can then be taken to the experimental field for selection and use without on-site preparation, reducing the occurrence of preparation errors.

[0109] The tube plug is made of rubber.

[0110] The male and / or female connectors are made of rubber.

[0111] In the above situations, it is best to use rigid structures for all supports and arms, while various pipelines such as branch pipes, main pipes, branch pipes, and drug dispensing pipes are best made of glass, which is also a rigid material. Other connecting components such as pipe plugs, male and female connectors can be made of flexible rubber materials. In particular, male and / or female connectors need to be connected to the branch pipe by rotating the branch pipe. To improve the success rate of fitting and the convenience of connection, both or at least one of them can be made of rubber material to facilitate connection.

[0112] The dispensing tube is equipped with a capacity system.

[0113] The branch pipes and / or main pipes and / or branch pipes are equipped with valves. Valves on the branch pipes control the output of each dispensing unit, valves on the main pipe control the overall main outlet of the dispensing device, and valves on the branch pipe plugs control the output of each dispensing pipe within the dispensing unit. Additionally, corresponding valves can be installed on the branch pipes to control the output of enhanced control dispensing units. However, to ensure the basic functions of the dispensing device, it is preferable to minimize the number of valves, or even eliminate all valves, to reduce unnecessary valve opening and closing operations. The purpose of the dispensing device is to dispense the prepared medication to the main output pipe through the separate rotation of multiple dispensing units. Generally, this process is irreversible; therefore, the principle for setting each valve should prioritize ensuring the independent safety of the medication, and some valves may be installed, or none may be installed at all.

[0114] Fourth embodiment:

[0115] like Figure 2 , 5 As shown, based on the above embodiments, the dispensing unit in this embodiment is provided with a control ring. The control ring is located at the rotating shaft and is used to control, limit, and position the opening and closing angle between the support arm and the branch pipe. The control ring includes an inner ring and an outer ring. The inner ring is fixedly connected to the branch pipe, and the outer ring is fixedly connected to the support arm. The inner ring and the outer ring are nested or overlapped and are coaxial. The inner ring of the control ring is provided with a first damping gear, and the outer ring is provided with a first toothed disc adapted to the damping gear. The first damping gear and the first toothed disc are meshed and assembled. The damping of the first damping gear is set to maintain the opening and closing angle between the support arm and the branch pipe without external force.

[0116] The branch pipe and the support arm are connected by a rotating shaft, and during use, the branch pipe and / or the support arm need to be rotated separately. If the structure of the branch pipe and support arm cannot be effectively controlled, it can easily lead to operational errors or even reagent spillage, affecting the normal and orderly conduct of the experiment. Therefore, this embodiment incorporates a damped control ring structure and a positioning locking structure between the branch pipe and the support arm, which can effectively control the position and opening / closing angle of the two components.

[0117] The first damping gear is equipped with a locking pin, and the gear plate is equipped with multiple locking holes that can be adapted to the locking pin. After the locking pin is adapted to the locking holes and connected, the opening and closing angle between the support arm and the support pipe is limited and cannot be changed.

[0118] The control ring is provided with a side ring, which is fixedly connected to the bracket. The side ring is nested or overlapped with the outer ring and the two are coaxial. The outer ring is provided with a second damping gear, and the side ring is provided with a second toothed disc adapted to the second damping gear. The second damping gear is meshed and assembled with the second toothed disc. The damping of the second damping gear is set to maintain the opening angle between the support arm and the bracket under no external force.

[0119] Based on the above structure, a side ring structure is set between the support arm and the bracket. Its setting principle is the same as that of the inner ring and outer ring between the support pipe and the support arm. The side ring is mainly used to set a damping structure between the support arm (the function extends to the support pipe) and the bracket that provides fixed support, which can effectively control the normal operation of the above components.

[0120] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solutions of the present invention and not to limit it. Although the present invention has been described in detail with reference to examples, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications and substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A medicament dispensing device dedicated to the cultivation of Silybum marianum, characterized in that: the medicament dispensing device comprises a support, a rotating shaft, branch pipes, a main pipe and a plurality of dispensing units, the number of branch pipes is consistent with the number of dispensing units, wherein: the support is a basic structure for providing fixation, connection, support and protection for the rotating shaft, branch pipes, main pipe and dispensing units, the rotating shaft is fixed on the support and provides rotating assembly connection for the dispensing units, the branch pipes are fixed on the support and connect with the dispensing units to establish the connection between the dispensing units and the main pipe, the main pipe is fixed on the support and collects all branch pipe lines and outputs uniformly, and the dispensing units are movably connected to the support through the rotating shaft and are used for dispensing medicaments; the dispensing unit comprises an arm and a branch pipe, one end of the arm is movably connected to the rotating shaft, the other end of the arm is provided with a plurality of dispensing pipes, the top end of the dispensing pipe is a mouth, the dispensing pipe mouth is fixed on the arm in parallel with the top up, and the branch pipe is movably connected to the rotating shaft at the middle part, one end of the branch pipe is provided with a mating male joint, the mating male joint is used to establish the connection between the branch pipe and the branch pipe, and the other end of the branch pipe is provided with a plurality of pipe plugs, the number of pipe plugs is consistent with the number of dispensing pipes, and the positions of the pipe plugs correspond to the dispensing pipe mouths one by one; one end of the branch pipe is provided with a mating female joint matched with the mating male joint of the branch pipe, when the one end of the branch pipe is rotated to approach the mating female joint of the branch pipe, the mating male joint and the mating female joint can be matched and connected, and the branch pipe and the branch pipe are communicated; the pipe plug is hollow, and the pipe plug is matched with the dispensing pipe mouth, when the pipe plug is buckled on the dispensing pipe, the hollow structure of the pipe plug communicates the branch pipe and the dispensing pipe; the pipe plug is made of rubber material; the mating male joint and / or the mating female joint are made of rubber material; the dispensing pipe is provided with a capacity system; the branch pipe and / or the main pipe and / or the pipe plug of the branch pipe are provided with a valve; the dispensing unit is provided with a control ring, the control ring is arranged at the rotating shaft, and the control ring is used to control, limit and position the opening angle between the arm and the branch pipe; the control ring comprises an inner ring and an outer ring, the inner ring is fixedly connected with the branch pipe, the outer ring is fixedly connected with the arm, the inner ring is nested or overlapped with the outer ring, and the inner ring and the outer ring are coaxial; a first damping gear is arranged on the inner ring of the control ring, a first tooth disc matched with the damping gear is arranged on the outer ring, the first damping gear is assembled and connected with the first tooth disc in meshing, and the damping of the first damping gear is set to keep the opening angle between the arm and the branch pipe unchanged under no external force.

2. The medicament dispensing device dedicated to the cultivation of Silybum marianum according to claim 1, characterized in that: the first damping gear is provided with a locking pin, a plurality of locking holes matched with the locking pin are arranged on the tooth disc, after the locking pin and the locking hole are matched and connected, the opening angle between the arm and the branch pipe is limited and cannot be changed.

3. The medicament dispensing device dedicated to the cultivation of Silybum marianum according to claim 1, characterized in that: ​ ​ The control ring is provided with a side ring fixedly connected to the support, the side ring is nested or overlapped with the outer ring and coaxial with the outer ring, the outer ring is provided with a second damping gear, the side ring is provided with a second tooth disc matched with the second damping gear, the second damping gear is assembled and connected with the second tooth disc in meshing, and the damping of the second damping gear is set to keep the opening and closing angle between the support arm and the support under no external force.

Citation Information

Patent Citations

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