Composition with anti-dandruff effect and preparation method thereof

Abstract

The present application discloses a composition with an anti-dandruff effect, which comprises the following raw materials by weight percentage: 3-7% of Swertia japonica extract, 3-7% of Sophora flavescens extract, 12-15% of dichlorobenzyl alcohol, 40-50% of cocamidopropyl PG-dimethyl ammonium chloride phosphate sodium, 12-20% of saccharide isomers, and the balance is water; the saccharide isomers are isomerized D-glucan and are derived from golden sweet corn fruit. The inventor creatively discovered that saccharide isomers and dichlorobenzyl alcohol have a synergistic effect on the inhibition of Malassezia, and at the same time effectively reduce the impact of surfactant residues on the scalp, which can reduce scalp health problems caused by surfactant residues.

Description

Technical Field

[0001] The invention relates to a composition with anti-dandruff effect and a preparation method thereof. Background Art

[0002] In the field of hair care, in addition to normal cleaning needs, people generally pursue healthy and smooth hair and hope to maintain a good hair quality level for a long time. In this regard, dandruff is a common problem. Dandruff is the keratinocytes that fall off the scalp. Under normal circumstances, keratinocytes fall off very little and very slowly, and will not be obviously seen. But under the influence of various factors, immature keratinocytes are produced in large quantities, clump and fall off, forming dandruff. Studies have shown that problems such as dandruff, itching and oily scalp are caused by Malassezia and other harmful colonies that use oil as a source of nutrition. Their abnormal reproduction destroys the microbial balance and scalp barrier of the scalp itself, and the harmful substances produced invade the scalp and cause inflammatory reactions, which in turn leads to excessive cell proliferation, more cell groups are produced on the surface of the scalp, and dandruff is formed after falling off.

[0003] In order to improve this problem, moisturizers such as hyaluronic acid are added to hair care products. The moisturizers form a protective film on the scalp to lock in moisture in the hair and scalp. However, since the hair needs to be rinsed many times during the washing process, the amount of hyaluronic acid added needs to be greatly increased in order to keep more moisturizer on the scalp. However, this hyaluronic acid formula design is prone to produce hydration on the scalp, and the sebaceous glands that originally maintain the water and oil balance of the scalp may be over-activated. In the case of over-activation, the number of Malassezia increases instead. Therefore, it is easy to have the trouble of washing your hair every day and having dandruff all over your head. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a composition with anti-dandruff effect and a preparation method thereof.

[0005] In order to solve the above-mentioned technical problems, the present invention adopts the following technical solutions:

[0006] A composition with an anti-dandruff effect comprises the following raw materials by weight percentage: 3-7% of Swertia japonica extract, 3-7% of Sophora flavescens extract, 12-15% of dichlorobenzyl alcohol, 40-50% of sodium cocamidopropyl PG-dimethylammonium chloride phosphate, 12-20% of saccharide isomers, and the balance is water; the saccharide isomers are isomerized D-glucan and are derived from golden sweet corn fruit.

[0007] Preferably, the method comprises the following steps:

[0008] Step 1: Soak fresh Sophora flavescens and Swertia japonica powder in pure water, activate with sodium chloride solution, adjust pH to 3-5, and prepare soaking solution;

[0009] Soak fresh Sophora flavescens and Swertia japonica powder in pure water, activate with sodium chloride solution, adjust pH to 3-5, and prepare soaking solution;

[0010] Step 2: transferring the soaking liquid to a microporous filter membrane for filtration to obtain a filter residue and a coarse filtrate, repeating step 1 for reflux extraction of the filter residue and then using a membrane ultrafiltration to obtain a first extract, using a membrane ultrafiltration to obtain a second extract, and mixing and concentrating the first extract and the second extract to obtain a concentrated solution;

[0011] Step 3: After the dichlorobenzyl alcohol, cocamidopropyl PG-dimethyl ammonium chloride phosphate sodium and the concentrated solution are stirred and dissolved, the saccharide isomers are added and stirred evenly to obtain a composition with an anti-dandruff effect. The beneficial effects of the present invention are:

[0012] 1. Dichlorobenzyl alcohol: As a broad-spectrum antibacterial agent, its antibacterial active ingredients are compatible with a wide range of products, have good temperature stability, are suitable for a wide pH range, and can effectively inhibit the proliferation of Malassezia.

[0013] 2. Sugar isomers are isomerized D-glucans manufactured by biochemical technology. Their main components are glucose, fructose, lactose, lactose products, mannose, galactose, and allulose, and they have a composition structure similar to that of the human stratum corneum. When used in skin cosmetics, they can combine with the ε-amino acid functional groups on the skin to regulate skin moisture, keep the skin moisturized for a long time, and relieve irritation; when used in hair cosmetics, they have good moisturizing, antistatic, and anti-aging effects. The inventors creatively discovered that they have a synergistic effect with dichlorobenzyl alcohol on the inhibition of Malassezia, and at the same time effectively reduce the impact of surfactant residues on the scalp, and can reduce scalp health problems caused by surfactant residues.

[0014] 3. Sophora flavescens extract: Sophora flavescens extract has anti-tumor, anti-angiogenic and leukocyte-raising effects, and can clear away dampness and heat in the lower abdomen, kill insects and relieve itching, and has a good effect in relieving skin itching.

[0015] 4. Swertia japonica extract: It has significant analgesic and sedative effects, and has anti-inflammatory and antiviral effects. It is easily absorbed through the skin surface, can dilate capillaries, and activate or promote the enzyme system of skin cells, improve the biochemical function of skin cells, and can effectively relieve scalp itching and other problems.

[0016] 5. Sodium cocamidopropyl PG-dimethylammonium chloride phosphate, a surfactant with a biomimetic phospholipid structure, has good affinity with the scalp. It helps dissolve dichlorobenzyl alcohol in the composition and also improves the combing properties of the hair. DETAILED DESCRIPTION

[0017] References to embodiments of the present invention will now be provided in detail, one or more examples of which are described below. Each example is provided as an explanation rather than a limitation of the present invention. In fact, it will be apparent to those skilled in the art that various modifications and variations may be made to the present invention without departing from the scope or spirit of the present invention. For example, a feature illustrated or described as part of one embodiment may be used in another embodiment to produce a further embodiment.

[0018] Therefore, it is intended that the present invention covers such modifications and variations that fall within the scope of the appended claims and their equivalents. Other objects, features and aspects of the present invention are disclosed in or are obvious from the following detailed description. Those of ordinary skill in the art will appreciate that this discussion is only a description of exemplary embodiments and is not intended to limit the broader aspects of the present invention.

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those generally understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0020] Except as shown in the operating examples or otherwise indicated, all numbers used in the specification and claims to indicate the amount of ingredients, physicochemical properties, etc. are understood to be adjusted by the term "about" in all cases. For example, therefore, unless otherwise indicated, the numerical parameters listed in the above specification and the attached claims are approximate values, and those skilled in the art can use the teachings disclosed herein to seek to obtain the desired properties and appropriately change these approximate values. The use of numerical ranges expressed as endpoints includes all numbers within the range and any range within the range, for example, 1 to 5 includes 1, 1.1, 1.3, 1.5, 2, 2.75, 3, 3.80, 4 and 5, etc.

[0021] Table 1 Shampoo formula examples

[0022]

[0023] Table 2 Examples of anti-dandruff compositions

[0024]

[0025] Taking Test 1 as an example, the preparation steps of other control groups and test groups refer to Test 1.

[0026] 1. Mix phase A, heat to 80°C, stir until completely dissolved, and homogenize at low speed for 2 minutes to promote complete miscibility of ethylene glycol distearate;

[0027] 2. Mix phase B and stir until completely dissolved;

[0028] 3. Add the pre-mixed dissolved phase B at 50-60°C and stir evenly;

[0029] 4. When the temperature drops below 45°C, add phase C and stir to mix evenly;

[0030] 5. Add the pre-mixed and dispersed phase D components and stir to mix evenly;

[0031] 6. Add the components of phase E, stir and mix evenly to prepare the anti-dandruff shampoo.

[0032] About the preparation method of phase E composition:

[0033] Step 1: Soak fresh Sophora flavescens and Swertia japonica powder in pure water, activate with sodium chloride solution, adjust pH to 3-5, and prepare soaking solution;

[0034] Step 2: transferring the soaking liquid to a microporous filter membrane for filtration to obtain a filter residue and a coarse filtrate, repeating step 1 for reflux extraction of the filter residue and then using a membrane ultrafiltration to obtain a first extract, using a membrane ultrafiltration to obtain a second extract, and mixing and concentrating the first extract and the second extract to obtain a concentrated solution;

[0035] Step 3: After the dichlorobenzyl alcohol, sodium cocamidopropyl PG-dimethylammonium chloride phosphate and the concentrated solution are stirred and dissolved, the saccharide isomers are added and continued to be stirred evenly to obtain a composition with an anti-dandruff effect.

[0036] In vitro antibacterial test:

[0037] The antibacterial effect was detected by the inhibition ring method: the culture medium used was agar culture medium, and the test strain was the standard strain of Malassezia furfur.

[0038] Test samples: test group and control group.

[0039] Experimental content: 1. Prepare 10 5 CFU bacterial suspension.

[0040] 2. Spread the culture medium evenly on the Leeming & Notman medium plate, and then place it on a sterile operating table to dry the bacterial solution on the plate.

[0041] 3. Add each shampoo composition sample to the above plate in a quantitative manner, culture it in a constant temperature incubator at 30°C for 5-7 days, observe the results, and record the measurement of the inhibition ring.

[0042] 4. Experimental results: The results are recorded as the diameter of the inhibition ring, unit: millimeter.

[0043] 5. The results were determined according to the standards of the National Committee for Clinical Trials Standards (NCCLS) of the United States: the diameter of the inhibition zone <8 mm was insensitive, 8-13 mm was low sensitive, 13-19 mm was moderately sensitive, and >19 mm was highly sensitive.

[0044] The experimental results are as follows:

[0045] Table 3

[0046]

[0047] Table 4

[0048]

[0049] Human patch test

[0050] 1. Test materials: Anti-dandruff shampoos prepared in Control 1-4 and Test 1 and 2 of the present invention.

[0051] 2. Experimental subjects: Recruit 30 volunteers, 15 males and 15 females, aged 20-50 years old.

[0052] 3. Test method: Use a closed patch test, put an equal amount (0.020mL-0.025mL) of the 6 anti-dandruff shampoo in a specific patch tester, apply it to the volunteer's arm with a hypoallergenic tape, press it lightly to make it evenly apply to the skin, and leave it for 24 hours; the blank control group is a volunteer who does not use the product. After 24 hours, remove the patch tester, observe the skin reaction after 0.5h, 24h, and 48h, and record the results. The level of adverse reactions to the skin is shown in the table below.

[0053] Table 5

[0054] The human patch test results are as follows

[0055] Table 6

[0056]

[0057] When the composition provided by the present invention is applied to shampoo, no adverse skin reaction occurs, while there is one case of grade 1 adverse reaction in controls 2 and 4. Therefore, the composition provided by the present invention can be applied to sensitive scalp.

[0058] Human efficacy evaluation

[0059] Test method: 60 subjects aged between 18 and 50 with severe dandruff symptoms and without hair diseases such as psoriasis were selected and randomly divided into 6 groups, and the shampoos of the test group and control group were used for 30 days, washing their hair every two days.

[0060] Subjective efficacy evaluation

[0061] The subjects self-assessed and made a subjective evaluation of the effect of the shampoo. The questionnaire survey was conducted to ask the subjects to self-evaluate the improvement of the number of dandruff on both sides of the scalp, the degree of scalp itching, the amount of scalp oil and hair gloss, the overall number of hair, etc., and the scores were 0 to 5, where 0 = no improvement; 1 = little improvement; 2 = slight improvement; 3 = obvious improvement; 4 = significant improvement; 5 = complete improvement or basic recovery.

[0062] The subjects gave their average scores to the six groups of shampoos after continuous use. See the table below for specific data.

[0063] Table 7

[0064]

[0065] From the test results in Table 3, it can be seen that the inhibition ring diameter of control 1 is 12.4 mm, and the inhibition ring diameter of control 2 is 14.8 mm; in the experiments of test 1 and test 2, dichlorobenzyl alcohol and saccharide isomers were compounded at the same time, and the inhibition ring diameter of test 1 was 19.4 mm, and the inhibition ring diameter of test 2 was 17.8 mm, which were both higher than the inhibition ring diameters of control 1 and control 2. It can be seen that dichlorobenzyl alcohol and saccharide isomers compounded in the system of the present application have a synergistic effect on the antibacterial effect of Malassezia furfur.

[0066] In order to further explore the effect of compounding dichlorobenzyl alcohol and saccharide isomers in the present application system, the present application also designed control 3 and control 4. In the shampoo of control 3, dichlorobenzyl alcohol and saccharide isomers were not compounded, and the antibacterial ring diameter was only 7.3 mm. In the shampoo of control 4, Japanese swertia extract and sophora flavescens extract were not compounded, and the antibacterial ring diameter was as high as 19.1 mm. However, in the efficacy evaluation of Table 7, the score of scalp itching was only 2.8, that is, after using shampoo, the problem of scalp itching was not effectively improved. Combining the experimental data of control 3, control 4, test 1, and test 2, it can be seen that the four raw material components of dichlorobenzyl alcohol, saccharide isomers, Japanese swertia extract, and sophora flavescens extract are compounded in shampoo, which can not only effectively inhibit Malassezia furfur, but also effectively relieve scalp itching.

[0067] This application compounded panthenol, beta glucan, trehalose, and hyaluronic acid in test 3, test 4, test 5, and test 6, respectively. The experimental results show that for the above conventional moisturizers, the diameters of the antibacterial rings are 13.5 mm, 14.7 mm, 14.1 mm, and 15.9 mm, respectively; the antibacterial effect is not ideal. The carbohydrate isomers used in this application are derived from golden sweet corn fruit. The carbohydrate isomers are isomerized D-glucans manufactured by biochemical technology and purchased from DSM-FIRMENICH. The main components are glucose, fructose, lactose, lactose products, mannose, galactose, and allulose. It has a composition structure similar to that of the human stratum corneum and is used in hair cosmetics. It has good moisturizing, antistatic, and anti-aging effects. The inventors creatively discovered that it has a synergistic effect with dichlorobenzyl alcohol in inhibiting Malassezia, and at the same time effectively reduces the impact of surfactant residues on the scalp, and can reduce scalp health problems caused by surfactant residues.

[0068] The test results in Table 7 show that the average overall scores of the compositions of Control 1, Control 2 and Control 4, which do not contain dichlorobenzyl alcohol, sugar isomers or Swertia japonica and Sophora flavescens extracts, are lower than 16 points; while the average overall scores of Test 1 and Test 2 are greater than 16 points, indicating that the composition prepared by the present invention has a better overall improvement on hair problems and has obvious anti-dandruff, soothing and antipruritic functions.

[0069] Although the present invention is described in detail with reference to the above embodiments, it is obvious to those skilled in the art through this disclosure that various changes or modifications may be made to the present invention without departing from the principle and spirit of the present invention defined by the claims. Therefore, the detailed description of the embodiments of the present disclosure is only used to explain, not to limit the present invention, but the scope of protection is limited by the content of the claims.

Claims

1. A composition having an anti-dandruff effect, characterized in that: The raw materials include the following components in percentage by weight: 3-7% of Swertia japonica extract, 3-7% of Sophora flavescens extract, 12-15% of dichlorobenzyl alcohol, 40-50% of sodium cocamidopropyl PG-dimethylammonium chloride phosphate, 12-20% of carbohydrate isomers, and the balance is water; the carbohydrate isomers are isomerized D-glucan and are derived from golden sweet corn fruit.

2. A method for preparing a composition having an anti-dandruff effect as claimed in claim 1, characterized in that: The following steps are included: Step 1: Soak fresh Sophora flavescens and Swertia japonica powder in pure water, activate with sodium chloride solution, adjust pH to 3-5, and prepare soaking solution; Step 2: transferring the soaking liquid to a microporous filter membrane for filtration to obtain a filter residue and a coarse filtrate, repeating step 1 for reflux extraction of the filter residue and then using a membrane ultrafiltration to obtain a first extract, using a membrane ultrafiltration to obtain a second extract, and mixing and concentrating the first extract and the second extract to obtain a concentrated solution; Step 3: After the dichlorobenzyl alcohol, sodium cocamidopropyl PG-dimethylammonium chloride phosphate and the concentrated solution are stirred and dissolved, the saccharide isomers are added and continued to be stirred evenly to obtain a composition with an anti-dandruff effect.

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