A composition with anti-UVB radiation and anti-aging effects and its application

Abstract

The present invention provides a composition with anti-UVB radiation and anti-aging effects and its application, belonging to the field of cosmetic technology. The composition is composed of the following components by weight: 0.08-0.32 parts of eugenol, 0.5-3.5 parts of myrcene, 1-7 parts of myricetin, 0.02-0.18 parts of trans-caryophyllene, 40-200 parts of plantagoside, 180-300 parts of verbascoside, 120-280 parts of isoergosterol, 2-18 parts of quercetin, 5-55 parts of hyperoside, 2-18 parts of ferulic acid, 2-18 parts of kaempferol and 8-32 parts of resveratrol. The composition provided by the present invention is of great significance in terms of photoaging damage effects such as anti-UVB radiation and anti-aging, the composition has a small amount, clear active ingredients, high application value, and is suitable for the preparation of large-scale industrial production of skin care products, and is suitable for preparing external cosmetics.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a composition with anti-UVB radiation and anti-aging effects and application thereof. Background Art

[0002] With the continuous improvement of material and cultural level, people have begun to pay attention to hot topics such as skin care, anti-oxidation, whitening and spot removal. Skin aging is a common and complex biological process involving the combined effects of intrinsic aging and external environmental factors.

[0003] The wavelength of ultraviolet rays is 100-400nm. According to the biological effects, they can be divided into three parts from low to high: UVC (100-290nm), UVB (290-320nm) and UVA (320-400nm). UVC can be absorbed by the ozone layer, and generally does not cause harm to the human body, does not cause tanning, but can cause erythema. UVB can penetrate the ozone layer and enter the earth's surface. It is the main band of solar radiation that causes photobiological effects on the skin. UVB mainly acts on the epidermis of human skin, causing erythema, and has the strongest damaging effect on the skin. UVA has a high radiation intensity and produces a series of photobiological effects, which can cause DNA damage. It can penetrate the dermis of human skin, causing skin darkening, pigmentation and skin aging. Long-term accumulated exposure can easily cause serious damage to the skin, and even cause skin cancer, melanoma, etc. UVB can cause immediate and severe skin damage, while UVA can cause long-term and chronic damage. Both show carcinogenic effects on the skin. Skin photoaging refers to the phenomenon of skin aging or accelerated aging due to long-term sunlight exposure. The clinical manifestations are rough and thickened skin, deeper skin grooves,

[0004] Symptoms include mottled pigmentation, etc. Ultraviolet rays can cause a series of biological damages such as photoaging of the skin, excessive pigmentation, inflammation, dryness and desquamation, which directly affect people's facial whitening and even threaten human skin health. Therefore, sun protection has attracted more and more attention.

[0005] There are many types of existing sunscreens, which can be roughly divided into two categories: physical UV shielding agents and chemical UV absorbers, but each has its own defects. As a relatively safe ingredient, the research on the active ingredients of traditional Chinese medicine has become one of the research hotspots in large-scale product development. Its material basis plays an important role in anti-UVB and anti-aging effects.

[0006] For example, Chinese patent CN110787222A discloses an extract with anti-aging effect, its preparation method and application, and the raw materials for preparing the Chinese medicine composition include: Angelica sinensis, Panax notoginseng and Radix Polygoni Multiflori. The invention uses modern Chinese medicine technologies such as supercritical extraction and macroporous resin to enrich the effective ingredients and remove harmful ingredients. The extract prepared by this method has good anti-aging effect, but its anti-UVB radiation effect is not good.

[0007] For example, Chinese patent CN117624395A discloses a bamboo fungus polysaccharide, a preparation method and application thereof, an ultraviolet light damage repair agent and application thereof. The bamboo fungus polysaccharide includes one or more of the bamboo fungus stalk crude polysaccharide, the bamboo fungus fruiting body crude polysaccharide and the bamboo fungus cap crude polysaccharide. The bamboo fungus polysaccharide provided by the invention can improve the survival rate and antioxidant enzyme activity of HSF cells after UVB light damage, reduce the MDA content and inhibit the increase of ROS levels, and has anti-photoaging properties.

[0008] However, most skin care products are currently derived from plant medicines or extracts, the specific amount of addition is unclear, the efficacy is single, and the skin care effect is not obvious. Therefore, the present invention provides a composition with clear active ingredients, small addition amount, and both anti-UVB radiation and anti-aging effects. Summary of the invention

[0009] Based on the deficiencies in the prior art, the present invention aims to provide a composition with anti-UVB radiation and anti-aging effects, and the composition is analyzed and determined by antioxidant experiments, cell superoxide dismutase content, cell malondialdehyde content, cell melanin relative content and tyrosinase content determination, zebrafish melanin relative content and tyrosinase determination. The results show that the composition has the effects of freckle removal and whitening, anti-radiation, anti-inflammatory, anti-oxidation, anti-aging, and sun protection. This characteristic formula is of great significance in terms of the effects of photoaging damage such as anti-UVB radiation and anti-aging. The composition provided by the present invention has a small dosage, clear active ingredients, high application value, and is suitable for the preparation of large-scale industrial production of skin care products, and is suitable for the preparation of external cosmetics.

[0010] In order to achieve the above object, the present invention adopts the following technical solutions:

[0011] On the one hand, the present invention provides a composition with anti-UVB radiation and anti-aging effects, which comprises the following components in parts by weight: 0.08-0.32 parts of eugenol, 0.5-3.5 parts of myrcene, 1-7 parts of myricetin, 0.02-0.18 parts of trans-caryophyllene, 40-200 parts of plantagoside, 180-300 parts of verbascoside, 120-280 parts of isoergosterol, 2-18 parts of quercetin, 5-55 parts of hyperoside, 2-18 parts of ferulic acid, 2-18 parts of kaempferol and 8-32 parts of resveratrol.

[0012] Preferably, the composition comprises the following components in parts by weight: 0.1-0.3 parts of eugenol, 1-3 parts of myrcene, 2-6 parts of myricetin, 0.04-0.16 parts of trans-caryophyllene, 80-160 parts of plantagoside, 200-280 parts of verbascoside, 140-260 parts of isoergosterol, 4-16 parts of quercetin, 10-50 parts of hyperoside, 4-16 parts of ferulic acid, 4-16 parts of kaempferol and 16-24 parts of resveratrol.

[0013] More preferably, the composition comprises the following components in parts by weight: 0.15-0.25 parts of eugenol, 1.5-2.5 parts of myrcene, 3-5 parts of myricetin, 0.08-0.12 parts of trans-caryophyllene, 100-140 parts of plantagoside, 220-260 parts of verbascoside, 180-220 parts of isoergosterol, 8-12 parts of quercetin, 20-40 parts of hyperoside, 8-12 parts of ferulic acid, 8-12 parts of kaempferol and 18-22 parts of resveratrol.

[0014] The mass ratio of isoergoside, hyperoside and resveratrol is 8-15:0.5-2.2:1; preferably, the mass ratio of isoergoside, hyperoside and resveratrol is 10:1.5:1.

[0015] The mass ratio of the psyllium glycoside, verbascoside, quercetin and kaempferol is 10-20:1.5-90:1:1; preferably, the mass ratio of the psyllium glycoside, verbascoside, quercetin and kaempferol is 12:24:1:1.

[0016] As a preferred embodiment, the composition comprises the following components in parts by weight: 0.2 parts of eugenol, 2 parts of myrcene, 4 parts of myricetin, 0.1 parts of trans-caryophyllene, 120 parts of plantagoside, 240 parts of verbascoside, 200 parts of isoergosterol, 10 parts of quercetin, 30 parts of hyperoside, 10 parts of ferulic acid, 10 parts of kaempferol and 20 parts of resveratrol.

[0017] On the other hand, the present invention also provides a method for preparing the above-mentioned composition, comprising the following steps: mixing the formulated amounts of eugenol, myrcene, myricetin, trans-caryophyllene, plantagoside, verbascoside, isoergosterol, quercetin, hyperoside, ferulic acid, kaempferol and resveratrol, and passing the mixture through a 120-mesh sieve to obtain the composition.

[0018] In another aspect, the present invention also provides use of the above composition in preparing cosmetics having anti-UVB radiation and anti-aging effects.

[0019] The cosmetics are essence, emulsion, facial mask, skin care water or facial cream.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] (1) The composition provided by the present invention has clear ingredients. By controlling the mass ratio of isoergosterol, hyperoside and resveratrol to 8-15:0.5-2.2:1 and the mass ratio of plantagoside, verbascoside, quercetin and kaempferol to 10-20:1.5-90:1:1, the interaction between the components is significantly increased, so that the composition has significant freckle removal, whitening, radiation resistance, sun protection, anti-inflammatory, antioxidant, anti-aging and other effects;

[0022] (2) The composition provided by the present invention was analyzed and determined by antioxidant experiments, cell superoxide dismutase content, cell malondialdehyde content, cell melanin relative content and tyrosinase content determination, zebrafish melanin relative content and tyrosinase determination. The results show that the composition has the effects of removing spots and whitening, anti-radiation, anti-inflammatory, anti-oxidation, anti-aging, and sun protection. This characteristic formula is of great significance in terms of anti-UVB radiation and anti-aging and other photoaging damage effects. The composition provided by the present invention has a small dosage, clear active ingredients, high application value, and is suitable for the preparation of large-scale industrial production of skin care products and for the preparation of external cosmetics. DETAILED DESCRIPTION

[0023] The following will be combined with the tables in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] Hereinafter, examples and comparative examples of the present invention will be shown to explain the composition of the present invention in more detail, but the present invention is not limited thereto.

[0025] The present invention does not limit the sources of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are all common commercial products in the technical field, and the purity is above 98%. The specific raw material information is shown in Table 1.

[0026] Table 1

[0027]

[0028] Example 1-5 A composition with anti-UVB radiation and anti-aging effects and its preparation method

[0029] The formula is as shown in Table 2:

[0030] Table 2

[0031]

[0032] The preparation method is:

[0033] The composition is obtained by mixing the formulated amounts of eugenol, myrcene, myricetin, trans-caryophyllene, plantagoside, verbascoside, isoergosterol, quercetin, hyperoside, ferulic acid, kaempferol and resveratrol, and passing the mixture through a 120-mesh sieve.

[0034] Comparative Example 1

[0035] The difference from Example 5 is that the mass ratio of isoergosterol, hyperoside and resveratrol is 4:20:1, that is, the formula is: 0.02 parts of eugenol, 2 parts of myrcene, 4 parts of myricetin, 0.1 parts of trans-caryophyllene, 120 parts of plantagoside, 240 parts of verbascoside, 40 parts of isoergosterol, 10 parts of quercetin, 200 parts of hyperoside, 10 parts of ferulic acid, 10 parts of kaempferol and 10 parts of resveratrol, and the preparation method is the same as that of Example 5.

[0036] Comparative Example 2

[0037] The difference from Example 5 is that the mass ratio of plantagoside, verbascoside, quercetin and kaempferol is 300:78:1:1, that is, the formula is 0.02 parts of eugenol, 2 parts of myrcene, 4 parts of myricetin, 0.1 parts of trans-caryophyllene, 300 parts of plantagoside, 78 parts of verbascoside, 200 parts of isoergosterol, 1 part of quercetin, 30 parts of hyperoside, 10 parts of ferulic acid, 1 part of kaempferol and 20 parts of resveratrol, and the preparation method is the same as Example 5.

[0038] Comparative Example 3

[0039] The only difference from Example 5 is that resveratrol is not added, the content of hyperoside is increased to 50 parts, and the contents of other components and the preparation method are the same as those in Example 5.

[0040] Comparative Example 4

[0041] The only difference from Example 5 is that resveratrol is replaced by an equal amount of chlorogenic acid (CAS No. 327-97-9), and the contents of other components and the preparation method are the same as those in Example 5.

[0042] Effect experiment:

[0043] 1. Experimental Materials

[0044] 1.1 Experimental equipment

[0045]

[0046] 1.2 Experimental cells and animals

[0047]

[0048] 2. In vitro antioxidant capacity determination

[0049] 2.1 Determination of antioxidant capacity of DPPH and ABTS

[0050] The antioxidant assay was performed using DPPH and ABTS working solution reagents, and the drugs in each group were gradiently diluted to 15 μg / mL, 31.25 μg / mL, 62.5 μg / mL, 125 μg / mL, 250 μg / mL, 500 μg / mL, and 1000 μg / mL. The antioxidant capacity of the positive group (a mixture of plantain extract, white lilac extract, and radix scutellariae extract. Plantain, white lilac, and radix scutellariae were collected from Yutan Town, Nanguan District, Changchun City, Jilin Province, China, and were extracted with 70% ethanol continuously under reflux, concentrated and vacuum-freezed) Example 1-5 and Comparative Example 1-4 were compared, and their related IC 50 value.

[0051] 2.2 Cell culture.

[0052] The drug was diluted with cell culture medium to 50 μg / mL, 100 μg / mL, 200 μg / mL, 400 μg / mL, 800 μg / mL, and 1600 μg / mL, and divided into a blank group, a positive group, Example 1-5 groups, and Comparative Example 1-4 groups. CCK8 reagent was used to determine the cell viability of different groups of B16-F10 cells after administration and the relevant cell viability IC was calculated. 50 value.

[0053] 2.2.3 Effects of different drug combinations on the relative content of melanin in B16-F10 cells.

[0054] The relative content of melanin and tyrosinase inhibition rate in B16-F10 cells were determined by different drug combinations. 5 Cells were inoculated into 12-well plates, 2 mL per well, and cultured for 24 h. Except for the blank group, the other experimental groups constructed the α-MSH-induced melanin high expression model and added 100 nM α-MSH for induction for 48 h, and then the cells were collected.

[0055] 3. Animal Experiments

[0056] Different drug compositions were diluted to 12.5μg / mL, 25μg / mL, 50μg / mL, 100μg / mL, 200μg / mL, and 400μg / mL with zebrafish culture medium. 9hpf embryos were placed in a 12-well plate, with 20 normally developed embryos in each well. Three groups were set up in parallel, and different concentrations of compositions were added to each well, which can be divided into a blank group, a positive group, Example 1-5 groups, and a comparative example 1-4 group. Cultured at a constant temperature of 28±0.5℃, the drug solution was replaced every 12 h, and the zebrafish survival rate was observed after 72 h. Calculation of the relevant zebrafish survival rate IC50 value.

[0057] 3.1 Effects of different drug combinations on the relative content of melanin and tyrosinase inhibition rate in zebrafish.

[0058] The zebrafish in each group were collected and their tissues were crushed and centrifuged at 10000 rpm / min at 4°C to determine the relative content of melanin and the tyrosinase inhibition rate in the zebrafish.

[0059] 3.2 Protective effects of different drug combinations against UVB-induced photoaging

[0060] Animal production certificate number: SCXK (Liao) 2020-0001. After three days of adaptive feeding, the rats were randomly divided into 10 groups, each with 10 rats, namely blank control group, drug administration group (positive drug group, comparative example 1-4 group, example 1-5 group). Before each administration, the rats were irradiated with UVB, and the area of ​​​​3cm×3cm of the hair on the back of the rats was removed. The back of the rats was 30-42 cm away from the light source, and the irradiation dose was 366 mJ / cm 2 The drug was administered by intragastric administration, with a volume of 12 mL / kg, for 14 consecutive days, once a day. The blank group was given a corresponding volume of pure water at 12 mL / kg.

[0061] 4. Data Processing

[0062] SPSS 23.0 software was used for statistical analysis and the data were expressed as mean ± standard deviation. The data were analyzed according to normal distribution. One-Way ANOVA method was used to compare the means among multiple groups. If P < 0.05, the difference was considered statistically significant.

[0063] 5. Results

[0064] 5.1 Table 3 Antioxidant capacity IC of DPPH and ABTS in each group 50 (μg / mL) value

[0065] Group Positive group Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 DPPH 32.98 33.65 34.42 46.53 32.25 28.81 43.66 45.94 50.13 47.65 ABTS 26.10 58.10 43.23 41.95 38.90 20.90 58.90 83.02 52.82 63.90

[0066] As shown in Table 3, in the concentration range of 15-1000 μg / mL, using DPPH and ABTS as antioxidant indicators, the IC 50 The lower the concentration of Examples 1-5 compared with Comparative Examples 1-4, the better the antioxidant activity. Therefore, the provided composition has a good free radical scavenging ability.

[0067] 5.2 Table 4 B16-F10 cell viability assay and calculation of relevant IC 50 (μg / mL) value

[0068] Group Positive group Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 B16-F10 cell viability 350 μg / mL 800 μg / mL 600 μg / mL 400 μg / mL 500 μg / mL 850 μg / mL 200 μg / mL 255 μg / mL 450 μg / mL 125 μg / mL

[0069] As shown in Table 4, within the concentration range of 50-1600 μg / mL, the CCK8 reagent was used to calculate the cell viability IC 50 Compared with comparative examples 1-4, the higher the concentration of Examples 1-5, the stronger the cell viability and the lower the toxicity.

[0070] 5.3 Table 5 Melanin content and tyrosinase activity of B16-F10 cells ( ±s)

[0071]

[0072] Note: ※Compared with the blank group, P<0.05; ※※Compared with the blank group, P<0.01;

[0073] *Compared with the model group, P < 0.05; **Compared with the model group, P < 0.01;

[0074] #Compared with comparative example 1, P<0.05; ##Compared with comparative example 1, P<0.01;

[0075] ○Compared with comparative example 2, P < 0.05; ○○Compared with comparative example 2, P < 0.01;

[0076] □Compared with comparative example 3, P < 0.05; □□Compared with comparative example 3, P < 0.01;

[0077] △Compared with Comparative Example 4, P<0.05; △△Compared with Comparative Example 4, P<0.01.

[0078] As shown in Table 5, compared with the blank group, the B16-F10 cells in the model group secreted a large amount of melanin after being stimulated by α-MSH, and the relative content of melanin in the cells increased significantly (P < 0.01), indicating that the model was successfully established.

[0079] Compared with the model group, the relative content of melanin and tyrosinase in Examples 1-5 and Comparative Examples 1-4 were significantly different (P<0.01), indicating that both the composition of the present invention and the composition provided in the comparative example can significantly reduce the relative content of melanin.

[0080] Compared with the comparative examples 1-4, the relative melanin content and tyrosinase content of B16-F10 cells in the examples 1-5 were significantly different (P<0.01), indicating that the composition of the present invention can reduce the generation of melanin to a certain extent compared with the composition provided in the comparative examples 1-4, and has the effect of whitening and removing spots.

[0081] 5.4 Table 6 Antioxidant damage capacity of rat skin tissue measured by SOD and MDA kits ( ±s)

[0082]

[0083] Note: ※Compared with the blank group, P<0.05; ※※Compared with the blank group, P<0.01;

[0084] *Compared with the model group, P < 0.05; **Compared with the model group, P < 0.01;

[0085] #Compared with comparative example 1, P<0.05; ##Compared with comparative example 1, P<0.01;

[0086] ○Compared with comparative example 2, P < 0.05; ○○Compared with comparative example 2, P < 0.01;

[0087] □Compared with comparative example 3, P < 0.05; □□Compared with comparative example 3, P < 0.01;

[0088] △Compared with Comparative Example 4, P<0.05; △△Compared with Comparative Example 4, P<0.01.

[0089] As shown in Table 6, compared with the blank group, the SOD activity of rats in the model group was significantly decreased (P < 0.01) and the MDA content was significantly increased (P < 0.01), indicating that the UVB-induced aging model was successfully established.

[0090] Compared with the model group, the SOD activity of rats in Example 1-5 and Comparative Example 1-4 groups was significantly different (P < 0.01). This shows that the composition of the present invention and the composition provided in the comparative example can significantly increase the SOD activity. The MDA content of the Example 1-5 and Comparative Example 1-4 groups was significantly different (P < 0.01). This shows that the composition of the present invention and the composition provided in the comparative example can reduce the MDA content.

[0091] Compared with the comparative examples 1-4, the SOD activity and MDA content of the rats in the examples 1-5 were significantly different (P<0.01), indicating that the composition of the present invention can repair the oxidative damage of UVB to rats to a certain extent, thereby delaying aging.

[0092] 5.5 Table 7 Zebrafish survival rate IC 50 Value (μg / mL) determination

[0093] Group Positive group Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Zebrafish survival rate 400 μg / mL 750 μg / mL 650 μg / mL 500 μg / mL 600 μg / mL 880 μg / mL 230 μg / mL 270 μg / mL 480 μg / mL 200 μg / mL

[0094] As shown in Table 7, the concentration range is controlled at 0-1 mg / mL and the zebrafish survival rate IC is calculated. 50 Compared with comparative examples 1-4, the higher the concentration of Example 1-5, the stronger the survival ability of zebrafish and the lower the toxicity.

[0095] 5.6 Table 8 Melanin content and tyrosinase activity in zebrafish ( ±s)

[0096]

[0097] Note: ※Compared with the blank group, P<0.05; ※※Compared with the blank group, P<0.01;

[0098] *Compared with the model group, P < 0.05; **Compared with the model group, P < 0.01;

[0099] #Compared with comparative example 1, P<0.05; ##Compared with comparative example 1, P<0.01;

[0100] ○Compared with comparative example 2, P < 0.05; ○○Compared with comparative example 2, P < 0.01;

[0101] □Compared with comparative example 3, P < 0.05; □□Compared with comparative example 3, P < 0.01;

[0102] △Compared with Comparative Example 4, P<0.05; △△Compared with Comparative Example 4, P<0.01.

[0103] As shown in Table 8, compared with the blank group, the relative content of melanin and tyrosinase in zebrafish in Examples 1-5 and Comparative Examples 1-4 were significantly different (P<0.01), indicating that both the composition of the present invention and the composition provided in the comparative example can significantly reduce the relative content of melanin.

[0104] Compared with the comparative examples 1-4, the relative melanin content and tyrosinase content in zebrafish of the examples 1-5 were significantly different (P<0.01), indicating that the composition of the present invention can reduce the generation of melanin to a certain extent compared with the composition provided in the comparative examples 1-4, and has the effect of whitening and lightening spots.

[0105] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A composition having anti-UVB radiation and anti-aging effects, characterized in that: The invention comprises the following components in parts by weight: 0.08-0.32 parts of eugenol, 0.5-3.5 parts of myrcene, 1-7 parts of myricetin, 0.02-0.18 parts of trans-caryophyllene, 40-200 parts of plantagoside, 180-300 parts of verbascoside, 120-280 parts of isoergosterol, 2-18 parts of quercetin, 5-55 parts of hyperoside, 2-18 parts of ferulic acid, 2-18 parts of kaempferol and 8-32 parts of resveratrol; The mass ratio of isoergosterol, hyperoside and resveratrol is 8-15:0.5-2.2:1; The mass ratio of the plantago glycoside, verbascoside, quercetin and kaempferol is 10-20:1.5-90:1:

1.

2. The composition according to claim 1, characterized in that: The invention is composed of the following components in parts by weight: 0.1-0.3 parts of eugenol, 1-3 parts of myrcene, 2-6 parts of myricetin, 0.04-0.16 parts of trans-caryophyllene, 80-160 parts of plantagoside, 200-280 parts of verbascoside, 140-260 parts of isoergosterol, 4-16 parts of quercetin, 10-50 parts of hyperoside, 4-16 parts of ferulic acid, 4-16 parts of kaempferol and 16-24 parts of resveratrol.

3. The composition according to claim 2, characterized in that: The invention is composed of the following components in parts by weight: 0.15-0.25 parts of eugenol, 1.5-2.5 parts of myrcene, 3-5 parts of myricetin, 0.08-0.12 parts of trans-caryophyllene, 100-140 parts of plantagoside, 220-260 parts of verbascoside, 180-220 parts of isoergosterol, 8-12 parts of quercetin, 20-40 parts of hyperoside, 8-12 parts of ferulic acid, 8-12 parts of kaempferol and 18-22 parts of resveratrol.

4. The composition according to claim 1, characterized in that: The mass ratio of the isoergosterol, hyperoside and resveratrol is 10:1.5:1; the mass ratio of the plantago glycoside, verbascoside, quercetin and kaempferol is 12:24:1:

1.

5. The composition according to claim 4, characterized in that: The composition consists of the following components in parts by weight: 0.2 parts of eugenol, 2 parts of myrcene, 4 parts of myricetin, 0.1 parts of trans-caryophyllene, 120 parts of plantagoside, 240 parts of verbascoside, 200 parts of isoergosterol, 10 parts of quercetin, 30 parts of hyperoside, 10 parts of ferulic acid, 10 parts of kaempferol and 20 parts of resveratrol.

6. A method for preparing the composition according to any one of claims 1 to 5, characterized in that: The method comprises the following steps: mixing eugenol, myrcene, myricetin, trans-caryophyllene, plantagoside, verbascoside, isoergosterol, quercetin, hyperoside, ferulic acid, kaempferol and resveratrol in a prescribed amount, and passing the mixture through a 120-mesh sieve to obtain the composition.

7. Use of the composition according to any one of claims 1 to 5 in the preparation of cosmetics having anti-UVB radiation and anti-aging effects.

8. The use according to claim 7, characterized in that: The cosmetics are essence, emulsion, facial mask, skin care water or facial cream.

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