An insecticide aerosol

Abstract

The application discloses an insecticidal aerosol, which comprises the following components in percentage by weight: 0.1%-2% of component A, 0.1%-5% of component B, 1%-70% of component C, and 23%-98.8% of component D; the component A is a compound shown in formula I; the component B is any one of chlorpyrifos, cis-cypermethrin, high-efficiency cypermethrin, phenothrin, transfluthrin, tefluthrin, cyfluthrin, d-cis-trans-chloropropyl acrylonitrile, teflubenzuron and methoxychlor, or a mixture of two or more thereof in any ratio; the component C is a solvent; and the component D is a propellant; the insecticidal aerosol can control the sprayed liquid amount to be 0.05ml-1ml through a special nozzle device, can quickly diffuse in space, and has the advantages of fast knockdown speed and high mortality rate on mosquitoes, flies and other pests.

Description

[0001] The present application is a divisional application of the Chinese patent application with the original application date of July 13, 2022, the application number of 202210823383.7, the invention title of Insecticidal aerosol, the publication number of CN 115669663 A, and the applicant proposes a divisional application. TECHNICAL FIELD

[0002] The present application relates to an insecticidal aerosol, which can quantitatively spray the drug solution into the space through a quantitative spraying device, so that the drug solution particles are more uniformly dispersed, the speed and persistence are improved, the use is convenient, the use amount of the preparation can be reduced, and the purpose of effectively preventing and controlling sanitary pests is ultimately achieved. BACKGROUND

[0003] The pyrethroid compound represented by formula I is a novel sanitary insecticide with good basic activity in preventing and controlling sanitary pests. The pyrethroid compound represented by formula I can be prepared according to the following reaction route:

[0004]

[0005] wherein R is methyl or ethyl, M is sodium or potassium, and R1 is hydrogen.

[0006] For example, 3-formyl-2,2-dimethylcyclopropane carboxylic acid methyl ester (CAS No. 62138-41-4) is used as the starting material, and condensation reaction is carried out with acetonitrile at 60℃ under the action of sodium ethoxide for 4 hours, the pH is neutralized to 8 by adding ethenesalicylic acid, and the oil layer is separated by liquid separation to obtain the intermediate 3-(2-cyano-1-vinyl)-2,2-dimethylcyclopropane carboxylic acid methyl ester.

[0007] In the obtained 3-(2-cyano-1-vinyl)-2,2-dimethylcyclopropane carboxylic acid methyl ester, 2,3,5,6-tetrafluorobenzyl alcohol, a catalytic amount of titanium acid tetraisopropyl ester and toluene solvent are added, and the temperature is slowly raised to reflux to produce by-product methanol, and the gas phase is controlled. After the raw material is completely converted, the temperature is lowered to 0-5℃, a small amount of water is added dropwise, separated, and desolventized to obtain the pyrethroid compound of formula I.

[0008] The pyrethroid compound of formula I in the corresponding configuration can be obtained by using different single configuration cyclopropane carboxylate as starting material, for example, using (1R, 3R)-3-formyl-2, 2-dimethylcyclopropane carboxylate methyl ester (CAS No. 27335-33-7) as starting material to synthesize, and then distributing crystallization to separate the double bond CN group Z, E isomers, so as to obtain single 2, 3, 5, 6-tetrafluorobenzyl- (1R, 3R)-3- [ (1Z)-2-cyano-1-vinyl] -2, 2-dimethylcyclopropyl carboxylate or 2, 3, 5, 6-tetrafluorobenzyl- (1R, 3R)-3- [ (1E)-2-cyano-1-vinyl] -2, 2-dimethylcyclopropyl carboxylate. Using (1R, 3S)-3-formyl-2, 2-dimethylcyclopropane carboxylate methyl ester (CAS No. 55701-02-5) can obtain 2, 3, 5, 6-tetrafluorobenzyl- (1R, 3S)-3- [ (1Z)-2-cyano-1-vinyl] -2, 2-dimethylcyclopropyl carboxylate or 2, 3, 5, 6-tetrafluorobenzyl- (1R, 3S)-3- [ (1Z)-2-cyano-1-vinyl] -2, 2-dimethylcyclopropyl carboxylate or 2, 3, 5, 6-tetrafluorobenzyl- (1R, 3S)-3- [ (1E)-2-cyano-1-vinyl] -2, 2-dimethylcyclopropyl carboxylate.

[0009] The pyrethroid compound has the advantages of high efficiency, low toxicity and low residue, and has good insecticidal activity for preventing and treating mosquito, fly or Blattella germanica and the like, and has been applied for many years and is well known. However, with the use for many years, mosquito, fly or Blattella germanica and the like have developed resistance to some traditional insecticides, resulting in decreased control effect. SUMMARY

[0010] The technical problem to be solved by the present application is to provide a kind of insecticidal aerosol, the pyrethroid compound shown in formula I, especially 2, 3, 5, 6-tetrafluorobenzyl- (1R, 3S)-3- [ (1Z)-2-cyano-1-vinyl] -2, 2-dimethylcyclopropyl carboxylate as the main component in view of the deficiencies in the prior art; the present application provides an insecticidal aerosol, which has very good control effect on mosquito, fly, bed bug, flea and the like by quantitative spraying, and further provides the preparation method of the insecticidal composition and its application in preventing and treating sanitary pests.

[0011] In order to achieve the above purpose, the technical scheme adopted by the present application is as follows:

[0012] An insecticidal aerosol, comprising the following components by weight percentage: 0.1%-2% of component A, 0.1%-5% of component B, 1%-70% of component C, 23%-98.8% of component D;

[0013] The component A is a compound shown in formula I, i.e. 2,3,5,6-tetrafluorobenzyl-3-[-2-cyano-1-vinyl]-2,2-dimethylcyclopropyl carboxylate;

[0014] The component B is any one of chlorpyrifos, cis-cypermethrin, high-efficiency cypermethrin, phenothrin, tefluthrin, tefen-thrin, cyfluthrin, d-cis-trans-chloropropyl chrysanthemate, tefen-methrin, methalofos, and a mixture of two or more thereof in any proportion.

[0015] The component C is a solvent; and the component D is a propellant.

[0016]

[0017] In the above technical solution, the component A shown in formula I has stereoisomerism due to the asymmetric carbon atom in the chrysanthemic acid part, and the component A according to the present application is any one of all active isomers or a mixture of two or more thereof in any proportion.

[0018] In the above technical solution, the component A is preferably 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropyl carboxylate, i.e. a compound with the stereoisomer of the ternary ring in the chrysanthemic acid part being 1R, trans.

[0019] In the above technical solution, the component B is preferably any one of chlorpyrifos, tefluthrin, d-cis-trans-chloropropyl chrysanthemate, tefen-methrin, and a mixture of two or more thereof in any proportion.

[0020] In the above technical solution, the component C is any one of water, dimethyl carbonate, propylene glycol methyl ether, glycerol butyl ether, propylene glycol butyl ether, tetrahydrofurfuryl alcohol, dimethyl adipate, dibutyl adipate, dibutyl carbonate, dimethyl succinate, decanamide, 5-ethylthio-1H-tetrazole, N,N-dimethyl decanamide, N,N-diethyl formamide, dimethyl glutarate, dipropylene glycol dimethyl ether, dimethyl amide, cyclohexane glycol monomethyl ether, methyl tert-butyl ether, acetyl citric acid tributyl ester, an alkane solvent of C8-18, an alcohol solvent of C2-8, and a mixture of two or more thereof in any proportion.

[0021] In the technical solution, the C8-18 alkane solvent is preferably any one of D60 (ExxonMobil Chemical Company), D80 (ExxonMobil Chemical Company), D100 (ExxonMobil Chemical Company), D110 (ExxonMobil Chemical Company), Isopar-E (ExxonMobil Chemical Company), Isopar-G (ExxonMobil Chemical Company), Isopar-H (ExxonMobil Chemical Company), Isopar-L (ExxonMobil Chemical Company), Isopar-M (ExxonMobil Chemical Company), octane, nonane, quianane, undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, or a mixture of two or more thereof in any ratio.

[0022] In the technical solution, the C2-8 alcohol solvent is preferably any one of ethanol, isopropanol, n-propanol, n-butanol, sec-butanol, tert-butanol, n-pentanol and its isomers, n-hexanol and its isomers, n-heptanol and its isomers, n-octanol and its isomers, or a mixture of two or more thereof in any ratio.

[0023] In the technical solution, the component D is liquefied petroleum gas, propane-dibutane, dimethyl ether or compressed air.

[0024] The insecticidal aerosol in the application can add synergists (such as PBO, etc.), fragrances, antioxidants (such as BHA, BHT, etc.) according to the needs of use.

[0025] The application also provides a preparation method of the above-mentioned insecticidal aerosol, comprising the following steps: mixing the components A, B and C (and the selected synergists, fragrances and bactericides according to the situation) in a proportion at 30-50°C, adding them into a spray tank provided with a quantitative spray valve (valve 0.05ml-1ml), and adding the component D into the spray tank under pressure to obtain an insecticidal aerosol capable of quantitative spraying.

[0026] The application also provides an application of the above-mentioned insecticidal aerosol in preventing and treating public place sanitary pests.

[0027] In the technical solution, when the insecticidal aerosol is used for preventing and treating public place sanitary pests, the application mode is spraying 2 times or more in a certain space through a quantitative spray valve, and the spraying times are determined according to the space size, and the average spraying times are 5m 3 Spray once.

[0028] In the technical solution, the public place refers to schools, residential buildings, hotels, shopping malls and the like.

[0029] The health pests include mosquitoes, flies, bedbugs, fleas and the like.

[0030] The health pests further include Culex pipiens pallens, Aedes albopictus, Aedes triseriatus, Aedes aegypti, Anopheles sinensis, Chironomus, Musca domestica, Muscina stabulans, Lucilia caprina, Lucilia sericata, Haematobia exigua, Haematobia irritans, Haematobia irritans and the like.

[0031] In use, the insecticidal aerosol in the application opens the valve of the quantitative spraying valve, generates a high-speed airflow under the pressure of the propellant, disperses and atomizes the effective component liquid in the aerosol canister to form mist droplets by using the vaporization energy of the propellant, and the sprayed mist droplets can quickly disperse and quickly diffuse in the space and remain on the ceiling, wall surface, ground and the like for 1-2 hours, with good quick-acting performance.

[0032] The insecticidal aerosol in the application controls the amount of sprayed liquid by the quantitative spraying valve, and sprays 2 times or more in a certain space, and the sprayed mist droplets can quickly disperse in the space, and compared with the existing conventional aerosol, the dose of quantitative spraying is relatively small, the sprayed solvent is also less, and the environment and human body are safer. 3 The preventive effect of 20m 3 The space only needs to be sprayed once in each of the four corners of the space to achieve the preventive effect, so that the purpose of effectively helping the liquid to be more evenly distributed in spaces of different sizes can be achieved.

[0033] The insecticidal aerosol in the application has the characteristics of knockdown, high lethality and low toxicity, and has good quick-acting performance and persistence, conforms to the national policy of increasing efficiency and reducing application, and the use method is more environmentally friendly, lower carbon, safer and more convenient compared with the conventional aerosol. DETAILED DESCRIPTION

[0034] The specific embodiments of the technical scheme of the application are described in detail below, but the application is not limited to the following description:

[0035] The application will be described below in combination with specific examples:

[0036] Preparation Example 1

[0037] An insecticidal aerosol is prepared by the following method:

[0038] 0.2 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 2 g of permethrin, and 27.8 g of D110 were mixed at 35° C. and added to a spray can equipped with a 0.5 ml metered spray valve. 70 g of propane and butane were pressed into the can, and after thorough shaking, the spray can was equipped with a spray nozzle to prepare Formulation Example 1.

[0039] Preparation Example 2

[0040] An insecticide aerosol is prepared by the following method:

[0041] 0.2 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 2 g of permethrin, 10 g of ethanol, and 17.8 g of propylene glycol butyl ether were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane and butane were pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Preparation Example 2.

[0042] Preparation Example 3

[0043] An insecticide aerosol is prepared by the following method:

[0044] 0.2 g of 2,3,5,6-tetrafluorobenzyl-3-[-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 2 g of permethrin, 10 g of ethanol, and 17.8 g of propylene glycol butyl ether were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane and butane were pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Preparation Example 3.

[0045] Preparation Example 4

[0046] An insecticide aerosol is prepared by the following method:

[0047] 0.6 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 2.4 g of cis-cypermethrin, 10 g of D100, and dimethyl carbonate were mixed at 35°C and added to a spray can equipped with a 0.5 ml metered spray valve. 70 g of propane and butane were pressed into the can, shaken thoroughly, and the spray can was equipped with a spray nozzle to prepare Formulation Example 4.

[0048] Preparation Example 5

[0049] An insecticide aerosol is prepared by the following method:

[0050] Formulation Example 5

[0051] Formulation Example 6

[0052] An insecticidal aerosol is prepared by the following method:

[0053] Formulation Example 7

[0054] Formulation Example 8

[0055] An insecticidal aerosol is prepared by the following method:

[0056] Formulation Example 9

[0057] An insecticidal aerosol is prepared by the following method:

[0058] Formulation Example 10

[0059] An insecticidal aerosol is prepared by the following method:

[0060] Formulation Example 11

[0061] An insecticidal aerosol is prepared by the following method:

[0062] 1.5 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 2.5 g of transfluthrin, 8 g of dimethyl succinate, and 18 g of isopropyl alcohol were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane was pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Formulation Example 9.

[0063] Preparation Example 10

[0064] An insecticide aerosol is prepared by the following method:

[0065] 0.4 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropyl carboxylate, 2.6 g of transfluthrin, 12 g of dipropylene glycol dimethyl ether, and 15 g of Isopar-G were mixed at 35° C. and added to a spray can equipped with a 0.5 ml metered spray valve. 70 g of propane and butane were pressurized into the can, and after thorough shaking, the spray can was equipped with a spray nozzle to prepare Formulation Example 10.

[0066] Formulation Example 11

[0067] An insecticide aerosol is prepared by the following method:

[0068] 0.4 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 2.6 g of tetrafluthrin, 12 g of methyl tert-butyl ether, and 15 g of Isopar-H were mixed at 35° C. and added to a spray can equipped with a 0.5 ml metered spray valve. 70 g of propane and butane were pressurized into the can, and after thorough shaking, the spray can was equipped with a spray nozzle to prepare Formulation Example 11.

[0069] Formulation Example 12

[0070] An insecticide aerosol is prepared by the following method:

[0071] 0.4 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 2.6 g of tetrafluthrin, 13.5 g of acetyl tributyl citrate, and 13.5 g of Isopar-L were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane and butane were pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Formulation Example 12.

[0072] Formulation Example 13

[0073] An insecticide aerosol is prepared by the following method:

[0074] 0.4 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 1.5 g of cypermethrin, 15 g of acetyl tributyl citrate, and 13.1 g of Isopar-M were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane and butane were pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Formulation Example 13.

[0075] Formulation Example 14

[0076] An insecticide aerosol is prepared by the following method:

[0077] 0.8 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 1.2 g of chlorfluanidine, 15 g of ethanol, and 13 g of cyclohexanediol monomethyl ether were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane and butane were pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Formulation Example 14.

[0078] Formulation Example 15

[0079] An insecticide aerosol is prepared by the following method:

[0080] 0.8 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 0.4 g of dextrorotatory trans-chlorpropamide, 15 g of ethanol, and 13.8 g of acetyl tributyl citrate were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane and butane were pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Preparation Example 15.

[0081] Formulation Example 16

[0082] An insecticide aerosol is prepared by the following method:

[0083] 1.2 g of 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate, 0.6 g of dextrorotatory trans-chlorprophmethrin, 20 g of ethanol, and 8.2 g of tetrahydrofurfuryl alcohol were mixed at 35° C. and added to a spray can. A 0.5 ml metered spray valve was installed, and 70 g of propane and butane were pressed into the can. After thorough shaking, the spray can was equipped with a spray nozzle to prepare Preparation Example 16.

[0084] Preparation Example 17

[0085] An insecticidal aerosol is prepared by the following method:

[0086] 2,3,5,6-tetrafluorobenzyl-(lR,3S)-3-[(lZ)-2-cyano-l-ethenyl]-2,2- dimethylcyclopropylcarboxylate 0.4 g, tetrachlorvinphos 0.6 g, ethanol 15 g, Dl 14 g are mixed at 35°C, added to a spray tank, fitted with a 0.5 ml metering valve, propanebutane 70 g is forced into the tank, and after thorough shaking, the spray tank is fitted with a spray head to give Preparation Example 17.

[0087] Preparation Example 18

[0088] An insecticidal aerosol is prepared by the following method:

[0089] 2,3,5,6-tetrafluorobenzyl-(lR,3S)-3-[(lZ)-2-cyano-l-ethenyl]-2,2- dimethylcyclopropylcarboxylate 0.6 g, tetrachlorvinphos 0.8 g, sunnetam 8 g, D60 20.6 g are mixed at 35°C, added to a spray tank, fitted with a 0.5 ml metering valve, propanebutane 70 g is forced into the tank, and after thorough shaking, the spray tank is fitted with a spray head to give Preparation Example 18.

[0090] Preparation Example 19

[0091] An insecticidal aerosol is prepared by the following method:

[0092] 2,3,5,6-tetrafluorobenzyl-(lR,3S)-3-[(lZ)-2-cyano-l-ethenyl]-2,2- dimethylcyclopropylcarboxylate 0.7 g, methothrin 0.9 g, ethanol 8 g, D80 20.4 g are mixed at 35°C, added to a spray tank, fitted with a 0.5 ml metering valve, propanebutane 70 g is forced into the tank, and after thorough shaking, the spray tank is fitted with a spray head to give Preparation Example 19.

[0093] Preparation Example 20

[0094] An insecticidal aerosol is prepared by the following method:

[0095] 2,3,5,6-tetrafluorobenzyl-(lR,3S)-3-[(lZ)-2-cyano-l-ethenyl]-2,2- dimethylcyclopropylcarboxylate 0.5 g, methothrin 1.2 g, dibutyl adipate 15 g, D100 13.3 g are mixed at 35°C, added to a spray tank, fitted with a 0.5 ml metering valve, propanebutane 70 g is forced into the tank, and after thorough shaking, the spray tank is fitted with a spray head to give Preparation Example 20.

[0096] Comparative Example 1

[0097] 2,3,5,6-tetrafluorobenzyl-(lR,3S)-3-[(lZ)-2-cyano-l-vinyl]-2,2- dimethylcyclopropylcarboxylate 0.2 g, permethrin 2 g, Dl 102 27.8 g were mixed at 35°C, added to a spray tank, fitted with a normal spray valve, and propanebutane 70 g was pressured into the tank. After being shaken well, a spray head was fitted to the spray tank to prepare Comparative Example 1.

[0098] Comparative Example 2

[0099] 2,3,5,6-tetrafluorobenzyl-(lR,3S)-3-[(lZ)-2-cyano-l-vinyl]-2,2- dimethylcyclopropylcarboxylate 0.4 g, tetrafluorothiofene 2.6 g, acetyl citric acid tributyl ester 12 g, Isopar-H 15 g were mixed at 35°C, added to a spray tank, fitted with a normal spray valve, and propanebutane 70 g was pressured into the tank. After being shaken well, a spray head was fitted to the spray tank to prepare Comparative Example 2.

[0100] Application Example

[0101] Test agent: Formulation Examples 1, 2, 3, 5, 6, 11, 12 of the present application, and Comparative Examples 1 and 2;

[0102] Test insect: Culex pipiens pallens, female adult of 3-5 days after emergence without blood sucking;

[0103] Test method 1: 100 Culex pipiens pallens were put into a 28 m 3

[0104] Table 1: Results of efficacy comparison of test method 1

[0105] Preparation number Total spray volume of preparation Active ingredient (mg) KT50 (minutes) Preparation Example 1 2ml 44 32.6 Preparation Example 2 2ml 44 28.7 Preparation Example 3 2ml 44 34.2 Comparative Example 1 1.6g (approximately 2ml) 44 62.8 Comparative Example 1 3.2g (approximately 4ml) 88 49.7 Comparative Example 1 4.8g (approximately 6ml) 132 33.7 Formulation Example 11 2ml 60 18.6 Formulation Example 12 2ml 60 19.2 Comparative Example 2 1.6g (approximately 2ml) 60 38.7 Comparative Example 2 4.8g (approximately 6ml) 180 19.5

[0106] As shown in Table 1, the efficacy of the conventional aerosol, such as Comparative Examples 1 and 2, is far worse than that of the metered aerosol. From the experimental data, the efficacy of the metered aerosol is about 3 times that of the conventional aerosol under the same formulation conditions, and the speed of efficacy is better.

[0107] Test method 2: 100 Culex pipiens pallens were put into a 28 m 3 ​In a simulation room (3.16 m long, 3.16 m wide, 2.8 m high), spray once at each of the four corners of the simulation room at a height of 2 m from the ground (Formulation Example), with a total spray volume of 2 ml. For the comparative example, spray normally and weigh the mixture. Calculate the volume of the sprayed mixture based on the specific gravity. After waiting for 1 hour, release 100 Culex pipiens pallens. Observe the number of Culex pipiens pallens knocked down within one hour, and calculate the half-knockdown time (KT50) of Culex pipiens pallens.

[0108] Table 2 Comparison results of the efficacy of test method 2

[0109] Preparation number Total spray volume of preparation Active ingredient (mg) KT50 (minutes) Preparation Example 1 2ml 44 42.7 Preparation Example 2 2ml 44 32.6 Preparation Example 3 2ml 44 42.3 Comparative Example 1 1.6g (approximately 2ml) 44 121.7 Comparative Example 1 3.2g (approximately 4ml) 88 100.6 Comparative Example 1 4.8g (approximately 6ml) 132 89.7 Formulation Example 11 2ml 60 30.7 Formulation Example 12 2ml 60 25.9 Comparative Example 2 1.6g (approximately 2ml) 60 100.8 Comparative Example 2 4.8g (approximately 6ml) 180 75.3

[0110] As can be seen from Table 2, when the test insects were placed in the spray chamber one hour after spraying, the efficacy of both the formulation examples and the comparative examples decreased. However, the efficacy of the comparative examples 1 and 2 decreased significantly. Although the efficacy of the formulation examples decreased, the decrease was smaller. This shows that the droplets of the quantitative spray are smaller, easier to diffuse in the air, and the droplet descent rate is slower. However, after one hour, most of the droplet particles of the conventional aerosol have fallen to the ground, which is also the reason for the obvious decrease in its efficacy.

[0111] And from the comparison of Preparation Examples 1 and 2, 11 and 12, it can be seen that the same quantitative spray, the same active ingredient ratio and concentration, the efficacy is different, mainly due to the influence of the solvent component in the formulation. The propylene glycol butyl ether in Preparation Example 2 and the acetyl tributyl citrate in Preparation Example 12 have a certain promoting effect on the atomization performance. The size of the spray droplets is determined by the spray device and the amount of propane and butane on the one hand, and by the solvent in the formulation system on the other.

[0112] Test method three: at 28m 3 In a simulation room (3.16 m long, 3.16 m wide, 2.8 m high), spray once at each of the four corners of the simulation room at a height of 2 m from the ground (Formulation Example), with a total spray volume of 2 ml. The comparative example was sprayed normally and weighed. The volume of the sprayed formulation was calculated according to the specific gravity. After waiting for 1 hour, the exhaust equipment was turned on to replace the air in the simulation room for 0.5 hours. Then, 100 Culex pipiens pallens were released. The number of Culex pipiens pallens knocked down was observed within one hour, and the half-knockdown time (KT50) of Culex pipiens pallens was calculated.

[0113] Table 3 Comparison results of the efficacy of three test methods

[0114] Preparation number Total spray volume of preparation Active ingredient (mg) KT50 (minutes) Preparation Example 1 2ml 44 158.6 Preparation Example 2 2ml 44 62.7 Preparation Example 5 2ml 60 55.3 Preparation Example 6 2ml 60 40.6

[0115] After air replacement, there should be no medicament in the simulated room space, most of the medicament falls to the ground or the medicament remaining in the space is drawn away by exhaust, theoretically, the drug efficacy of the preparation examples 1 and 2 should be similar, and the drug efficacy of the preparation examples 5 and 6 should be similar, but the difference is very large according to the test data, and it is found through research that adding propylene glycol butyl ether and propylene glycol methyl ether in the formula will make the sprayed droplets have certain stickiness, when the droplets fill the entire space, a part of the droplets will adhere to the wall, ceiling, and the normal habit of Culex pipiens pallens is to inhabit the ground, wall, ceiling, so relatively the drug efficacy will be more durable.

[0116] The above examples are only for illustrating the technical concept and technical features of the present application, and cannot limit the protection scope of the present application. Any equivalent transformation or modification according to the essence of the present application should be covered in the protection scope of the present application.

Claims

1. An insecticide aerosol, characterized in that: The invention comprises the following components in weight percentage: 0.1%-2% of component A, 0.1%-5% of component B, 1%-70% of component C, and 23%-98.8% of component D; The component A is 2,3,5,6-tetrafluorobenzyl-(1R,3S)-3-[(1Z)-2-cyano-1-vinyl]-2,2-dimethylcyclopropylcarboxylate; The component B is any one of permethrin, beta-cypermethrin, and permethrin, or a mixture of two or more of the above in any proportion; The component C is a mixture of any two or more of propylene glycol methyl ether, propylene glycol butyl ether, methyl tert-butyl ether, acetyl tributyl citrate, C8-18 alkane solvents, and C2-8 alcohol solvents in any proportion; The component D is liquefied petroleum gas, propane, butane, dimethyl ether or compressed air.

2. A method for preparing the insecticide aerosol according to claim 1, characterized in that: The following steps are involved: Components A, B and C in the stated proportions are mixed at 30-50° C., added to a spray can equipped with a metered spray valve, and component D is added to the spray can under pressure to obtain an insecticide aerosol capable of quantitative spraying.

3. Use of the insecticide aerosol according to claim 1 in preventing and controlling sanitary pests in public places, characterized in that: The application method is to spray twice or more times in a certain space through a quantitative spray valve. The number of sprays is determined according to the size of the space, with an average of 1 spray per 5m³. The public places mentioned include schools, residential houses, hotels, and shopping malls. The sanitary pests mentioned refer to mosquitoes, flies, bedbugs, and fleas.

Images