A circadian rhythm setting and regulation device

Abstract

This invention relates to the field of animal experimental equipment and discloses a circadian rhythm setting and adjustment device, comprising a cylindrical cage and a rotating base. Multiple support legs are fixedly installed at the lower end of the cage. The rotating base is located below the cage. Several ventilation mesh openings are provided on the cage. A fixed cylinder is fixedly inserted into the middle of the cage. The cage, rotating base, and fixed cylinder form an annular space for mouse movement. A mounting frame is fixedly installed inside the fixed cylinder, and a motor that drives the rotating base is fixedly installed on the mounting frame. A fan-shaped opening is provided on the cage, and a fan-shaped block is fixedly installed inside the fan-shaped opening by bolts. A movable strip is provided at the lower end of the fan-shaped block, with the end of the movable strip extending out of the cage. An arc-shaped stop is fixedly installed at the lower end of the movable strip. The purpose is to solve the problem that mouse excrement accumulates inside the device during use in existing circadian rhythm setting and adjustment devices, making cleaning and collection difficult.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of animal experiment instruments, and particularly relates to a circadian rhythm setting and adjusting device. BACKGROUND

[0002] Insomnia is a common clinical disease and problem that plagues modern people. According to reports, about 30% of adults worldwide suffer from insomnia, so the research and prevention work of insomnia is imminent.

[0003] In biomedical research, we often rely on the use of animal models to verify experimental and clinical hypotheses in order to more effectively understand the occurrence, development rules and research prevention measures of human diseases. Therefore, the use of animal models has become an extremely important experimental method and means in modern biomedical research, and rats and mice are the most commonly used experimental animals, accounting for more than 90% of the use rate of experimental animals. In order to obtain a sleep deprivation model, the mouse needs to be placed in a circadian rhythm setting and adjusting device, and the mouse is disturbed to prevent the mouse from entering a sleep state. However, the existing circadian rhythm setting and adjusting device has the problem that the mouse excrement continuously accumulates in the interior of the device, which is difficult to clean and collect. Therefore, we propose a circadian rhythm setting and adjusting device to solve the above problems. SUMMARY

[0004] The purpose of the present application is to solve the problem that the existing circadian rhythm setting and adjusting device has the problem that the mouse excrement continuously accumulates in the interior of the device, which is difficult to clean and collect.

[0005] To achieve the above technical purposes, the technical scheme adopted by the present application is as follows:

[0006] A circadian rhythm setting and adjusting device, comprising a cylindrical cage and a rotating base plate, a plurality of support feet are fixedly installed at the lower end of the cage, the rotating base plate is arranged below the cage, a plurality of air permeable mesh openings are formed in the cage, a fixed cylinder is fixedly inserted in the middle of the cage, an annular space for the mouse to move is formed between the cage, the rotating base plate and the fixed cylinder, a mounting bracket is fixedly installed in the fixed cylinder, a motor for driving the rotating base plate to rotate is fixedly installed on the mounting bracket, a fan-shaped opening is formed in the cage, a fan-shaped block is fixedly installed in the fan-shaped opening through bolts, a movable strip is arranged at the lower end of the fan-shaped block, the movable strip extends out of the cage at the end, an arc-shaped blocking strip is fixedly installed at the lower end of the movable strip, a plug rod is fixedly installed on the movable strip, a plug slot is formed in the fan-shaped block, and the upper end of the plug rod penetrates through the plug slot.

[0007] Further limited, the upper end of the plug rod is rotatably mounted with a pulling column, the pulling column is fixedly mounted with a protrusion, and the plug slot is provided with a groove matched with the protrusion. Such structure design, through the pulling column can pull the plug rod and the movable strip, cooperate with the protrusion and the groove, can make the movable strip keep upward state.

[0008] Further limited, the upper part of the fan-shaped block is provided with a cavity for storing sand and stone, the upper end of the fan-shaped block is provided with a feeding port communicated with the cavity, the feeding port is movably mounted with a movable plug, and the side surface of the fan-shaped block is provided with a strip-shaped port communicated with the bottom of the cavity. The cavity wall is provided with an electromagnetic valve at the strip-shaped port. Such structure design, through the feeding port can add sand and stone into the cavity, under the cooperation of the electromagnetic valve, the sand and stone can be scattered on the rotating base to prevent the excrement of the mouse from directly falling on the rotating base, and the problem of adhesion affecting use is generated.

[0009] Further limited, the middle part of the rotating base is fixedly mounted with a connecting column, the connecting column is provided with a connecting square groove, the output shaft of the motor is provided with an insertion block matched with the connecting square groove, the lower end of the rotating base is fixedly mounted with a clamping ring, the clamping ring is rotatably mounted with a rotating seat, and the bottom of the rotating seat is located on the same horizontal plane as the bottom of the supporting leg. Such structure design, when the cage is placed above the rotating base, the insertion block will be inserted into the connecting square groove of the connecting column, and when the motor works, the rotating base can be driven to rotate above the rotating seat.

[0010] Further limited, the top of the cage is uniformly provided with a plurality of openings, a plurality of the openings are movably inserted with a partition plate, and the top of the partition plate is fixedly mounted with a limiting strip. Such structure design, the partition plate inserted into the opening can separate the annular space in the cage to form a plurality of spaces for the mouse to move, and through the limiting action of the limiting strip on the partition plate, the bottom of the partition plate and the rotating base will form a distance for the sand and stone to pass through, so as to not affect the sleep deprivation experiment.

[0011] Further limited, the upper end of the cage is provided with a plurality of round holes, the plurality of round holes are staggered with the plurality of openings, the cage is hingedly connected with a plurality of cover plates matched with the round holes, the cover plates are fixedly mounted with fixing columns, and the upper end of the cage is provided with a positioning member capable of locking the cover plates in the round holes. Such structure design, through the cover plates, the mice required for the experiment can be taken and placed.

[0012] Further limited, the positioning member comprises an adapter column and a locking block, the adapter column is rotatably mounted on the upper end of the cage, and the locking block is rotatably mounted on the adapter column. Such structure design, simple structure, convenient to use.

[0013] Further limited, the top center of the cage is movably mounted with a rotating handle.

[0014] Further limited, the fixed cylinder is movably mounted with a plurality of storage boxes on the side close to the inside of the cage, the storage boxes are each provided with a partition plate, the storage boxes are divided into a feeding groove and a water storage groove under the partition plate, a plurality of feeding holes and perforations are formed in the upper end of the cage, the feeding holes are arranged directly above the feeding groove, the perforations are arranged directly above the water storage groove, a water inlet pipe is fixedly inserted into the perforations, and the lower end of the water inlet pipe extends into the water storage groove.

[0015] Further limited, a monitoring assembly is arranged outside the cage, the monitoring assembly comprises a C-shaped seat, a plurality of supporting rods, a mounting frame, a sleep monitor and a camera, the supporting rods are fixedly installed on the C-shaped seat, the mounting frame is movably installed on the supporting rods, the sleep monitor and the camera are movably installed on the mounting frame, a lead wire is connected to the signal input end of the sleep monitor, the top of the cage and the cover plate are made of transparent material, and a gap slot is formed in the cover plate for the lead wire to pass through.

[0016] The application with the above technical scheme has the following advantages:

[0017] When the motor works, the rotating base is driven to rotate relative to the cage, at this time, the mouse located on the rotating base is disturbed, so that the mouse is prevented from entering a sleep state, and the sleep deprivation experiment of the mouse can be performed.

[0018] The separating plate and the limiting strip cooperate, when the separating plate is arranged in the opening, the separating plate separates the annular space in the cage, the sleep deprivation experiment of different numbers of mice can be performed according to needs, and the separating plate and the limiting strip are simple in structure and convenient to use. BRIEF DESCRIPTION OF DRAWINGS

[0019] The application can be further illustrated by the non-limiting embodiments shown in the drawings.

[0020] Figure 1 It is a structural schematic view of the day-night rhythm setting and adjusting device;

[0021] Figure 2Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application when the cover plate is opened;

[0022] Figure 3 Structure diagram of the separation of the partition plate and the rotating base from the cage in the day-night rhythm setting and adjusting device of the present application;

[0023] Figure 4 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application; Figure 3 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application;

[0024] Figure 5 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application; Figure 3 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application;

[0025] Figure 6 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application;

[0026] Figure 7 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application;

[0027] Figure 8 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application;

[0028] Figure 9 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application;

[0029] Figure 10 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application; Figure 8 Structure diagram of the cage in the day-night rhythm setting and adjusting device of the present application;

[0030] Main component symbol explanation as follows:

[0031] 1, cage; 10, support foot; 11, air-permeable mesh opening; 12, fixing cylinder; 13, motor;

[0032] 2, rotating base; 21, connecting column; 22, connecting square groove; 23, insertion block; 24, clamping ring; 25, rotating seat;

[0033] 3, fan-shaped block;

[0034] 31, movable strip; 311, arc-shaped blocking strip;

[0035] 32, insertion rod; 321, pulling column; 322, protruding block;

[0036] 33, cavity; 34, movable plug; 35, strip-shaped opening;

[0037] 4, opening; 41, partition plate; 42, limiting strip;

[0038] 5, round hole; 51, cover plate; 52, fixed column; 53, adapter column; 54, locking block;

[0039] 6, rotating handle;

[0040] 7, storage box; 71, water inlet pipe;

[0041] 8, C-shaped seat; 81, support rod; 82, mounting bracket; 83, sleep monitor; 84, camera. DETAILED DESCRIPTION

[0042] The application will be described in detail below with reference to the drawings and specific examples. It should be noted that in the drawings or description, similar or identical parts are denoted by the same reference numerals, and the implementation not shown or described in the drawings is in a form known to those skilled in the art. In addition, the directional terms mentioned in the examples, such as "up", "down", "top", "bottom", "left", "right", "front", "back", etc., are only with reference to the direction of the drawings, and are not intended to limit the scope of protection of the application.

[0043] As shown in the drawings, Figures 1-10 A circadian rhythm setting and adjusting device of the application comprises a cylindrical cage 1 and a rotating base plate 2. The cage 1 is provided with a lighting lamp and a timer for controlling the operation of the lighting lamp, so as to model the circadian rhythm disorder caused by light. A plurality of supporting legs 10 are fixedly installed at the lower end of the cage 1. The rotating base plate 2 is arranged below the cage 1. A plurality of air-permeable mesh openings 11 are formed in the cage 1. A fixed cylinder 12 is fixedly inserted into the middle part of the cage 1. An annular space for the mouse to move is formed between the cage 1, the rotating base plate 2 and the fixed cylinder 12. A mounting bracket is fixedly installed in the fixed cylinder 12. A motor 13 for driving the rotating base plate 2 to rotate is fixedly installed on the mounting bracket. A fan-shaped opening is formed in the cage 1. A fan-shaped block 3 is fixedly installed in the fan-shaped opening by means of bolts. An active strip 31 is arranged at the lower end of the fan-shaped block 3. The end of the active strip 31 extends out of the cage 1. An arc-shaped blocking strip 311 is fixedly installed at the lower end of the active strip 31. An insertion rod 32 is fixedly installed on the active strip 31. An insertion slot is formed in the fan-shaped block 3. The upper end of the insertion rod 32 penetrates through the insertion slot. A rotating handle 6 is movably installed at the center of the top of the cage 1.

[0044] A pulling column 321 is rotatably installed at the upper end of the insertion rod 32. A protruding block 322 is fixedly installed on the pulling column 321. A groove matching the protruding block 322 is formed in the insertion slot.

[0045] The upper part of the fan-shaped block 3 is provided with a cavity 33 for storing sand and gravel, the upper end of the fan-shaped block 3 is provided with a feeding port in communication with the cavity 33, the feeding port is movably provided with a movable plug 34, and the side surface of the fan-shaped block 3 is provided with a strip-shaped port 35 in communication with the bottom of the cavity 33. The cavity wall of the cavity 33 is provided with an electromagnetic valve at the strip-shaped port 35. When the electromagnetic valve is opened, the sand and gravel in the cavity 33 will be scattered outward from the strip-shaped port 35 under the action of gravity, so that when the movable strip 31 pushes away the sand and gravel and mouse excrement on the rotating base 2, the clean sand and gravel is filled on the rotating base 2, so as to ensure the subsequent sleep deprivation experiment.

[0046] The middle part of the rotating base 2 is fixedly provided with a connecting column 21, the connecting column 21 is provided with a connecting square groove 22, the output shaft of the motor 13 is provided with a plug 23 matched with the connecting square groove 22, the lower end of the rotating base 2 is fixedly provided with a clamping ring 24, the clamping ring 24 is rotatably provided with a rotating seat 25, and the bottom of the rotating seat 25 is located on the same horizontal plane as the bottom of the supporting leg 10.

[0047] The top of the cage 1 is uniformly provided with a plurality of openings 4, a plurality of partition plates 41 are movably inserted into the plurality of openings 4, the top of the partition plate 41 is fixedly provided with a limiting strip 42, the limiting strip 42 keeps the partition plate 41 at a certain distance from the rotating base 2, so as to prevent the partition plate 41 from pushing the sand and gravel and mouse excrement on the rotating base 2, and the partition plate 41 divides the annular space, and a single space can accommodate a group (a plurality) of mice.

[0048] The upper end of the cage 1 is provided with a plurality of circular holes 5, the plurality of circular holes 5 are staggered with the plurality of openings 4, the cage 1 is hingedly provided with a plurality of cover plates 51 matched with the circular holes 5, the cover plate 51 is fixedly provided with a fixing column 52, and the upper end of the cage 1 is provided with a positioning piece capable of locking the cover plate 51 in the circular hole 5. The positioning piece comprises a connecting column 53 and a locking block 54, the connecting column 53 is rotatably installed on the upper end of the cage 1, and the locking block 54 is rotatably installed on the connecting column 53.

[0049] The plurality of storage boxes 7 are fixedly installed on the side close to the inside of the cage 1, and the plurality of storage boxes 7 are each provided with a partition plate. The storage box 7 is divided into a feeding groove and a water storage groove under the partition of the partition plate. The upper end of the cage 1 is provided with a plurality of feeding holes and perforations, the feeding holes are arranged directly above the feeding groove, the perforations are arranged directly above the water storage groove, the perforations are fixedly provided with a water inlet pipe 71, and the lower end of the water inlet pipe 71 extends into the water storage groove.

[0050] The cage 1 is externally provided with a monitoring assembly, the monitoring assembly comprises a C-shaped seat 8, a plurality of supporting rods 81, a mounting rack 82, a sleep monitor 83 and a camera 84, the plurality of supporting rods 81 are fixedly installed on the C-shaped seat 8, the mounting rack 82 is movably installed on the plurality of supporting rods 81, the sleep monitor 83 and the camera 84 are movably installed on the mounting rack 82, a signal input end of the sleep monitor 83 is connected with a lead wire, the top of the cage 1 and the cover plate 51 are transparent materials, and a gap slot for the lead wire to pass through is formed in the cover plate 51.

[0051] The use method of the present application is as follows:

[0052] In use, the partition plate 41 is inserted into the opening 4 as required, the annular space in the cage 1 is partitioned, then the cover plate 51 is opened, the mouse is put into the cage 1, after the cover plate 51 is closed, the locking block 54 is rotated, the locking block 54 is rotated to above the cover plate 51, and the cover plate 51 is in a locked state;

[0053] The motor 13 works, the output shaft drives the connecting column 21 and the rotating disc 2 to rotate on the rotating seat 25, at this time, the mouse on the rotating disc 2 is continuously disturbed, so that the mouse is prevented from entering a sleep state, and the sleep deprivation experiment is ensured to be carried out;

[0054] When the mouse excrement on the rotating disc 2 accumulates too much, the rotating pulling column 321 is rotated, the protruding block 322 is located above the groove, then the pulling column 321 and the inserting rod 32 are pushed downwards, until the movable strip 31 contacts the upper end of the rotating disc 2, with the continuous rotation of the rotating disc 2, the movable strip 31 can push the sand together with the mouse excrement away from the cage 1, so that the sand and the mouse excrement are discharged from below the fan-shaped opening;

[0055] After the sand and the mouse excrement are discharged, the movable strip 31 is pulled upwards through the pulling column 321 and the inserting rod 32, so that the movable strip 31 returns to the initial state, the electromagnetic valve works, the strip-shaped opening 35 is in a conductive state, and the clean sand is scattered on the rotating disc 2 under the action of gravity, until the sand completely covers above the rotating disc 2, and the electromagnetic valve is closed;

[0056] When the experiment is finished, the cage 1 can be lifted upwards through the rotating handle 6, so that the cage 1 is separated from the rotating disc 2, and the cage 1 and the rotating disc 2 are conveniently cleaned.

[0057] The diurnal rhythm setting and adjusting device is described in detail. The description of the specific embodiments is only used to help understand the method and the core idea of the present application. It should be pointed out that, for ordinary skilled persons in the technical field, some improvements and modifications can be made to the present application without departing from the principle of the present application, and these improvements and modifications also fall within the protection scope of the present application.

Claims

1. A circadian rhythm setting and adjusting device comprising a cylindrical cage (1) and a rotating base plate (2), characterized in that: The lower end of the cage (1) is fixedly installed with a plurality of supporting feet (10), the rotating base (2) is arranged below the cage (1), a plurality of air venting mesh openings (11) are formed in the cage (1), a fixed cylinder (12) is fixedly inserted in the middle of the cage (1), the cage (1), the rotating base (2) and the fixed cylinder (12) form an annular space for the mouse to move, a mounting rack is fixedly installed in the fixed cylinder (12), a motor (13) for driving the rotating base (2) to rotate is fixedly installed on the mounting rack, a fan-shaped opening is formed in the cage (1), a fan-shaped block (3) is fixedly installed in the fan-shaped opening through bolts, a movable strip (31) is arranged at the lower end of the fan-shaped block (3), the end of the movable strip (31) extends out of the cage (1), an arc-shaped blocking strip (311) is fixedly installed at the lower end of the movable strip (31), an insertion rod (32) is fixedly installed on the movable strip (31), an insertion slot is formed in the fan-shaped block (3), the upper end of the insertion rod (32) penetrates through the insertion slot; The upper end of the insertion rod (32) is rotatably installed with a pulling column (321), a protrusion (322) is fixedly installed on the pulling column (321), a groove matching the protrusion (322) is formed in the insertion slot; A cavity (33) for storing sand and stones is formed in the upper part of the fan-shaped block (3), a feeding opening communicating with the cavity (33) is formed in the upper end of the fan-shaped block (3), a movable plug (34) is movably installed in the feeding opening, a strip-shaped opening (35) communicating with the bottom of the cavity (33) is formed in the side of the fan-shaped block (3), an electromagnetic valve is arranged at the cavity wall of the cavity (33) at the strip-shaped opening (35); A plurality of openings (4) are uniformly formed at the top of the cage (1), a plurality of partition plates (41) are movably inserted in the openings (4), limit strips (42) are fixedly installed at the top of the partition plates (41).

2. A circadian rhythm setting and adjustment device according to claim 1, characterized in that: A connecting column (21) is fixedly installed in the middle of the rotating base (2), a connecting square slot (22) is formed in the connecting column (21), an insertion block (23) matching the connecting square slot (22) is arranged on the output shaft of the motor (13), a clamping ring (24) is fixedly installed at the lower end of the rotating base (2), a rotating seat (25) is rotatably installed on the clamping ring (24), the bottom of the rotating seat (25) is located on the same horizontal plane as the bottom of the supporting feet (10).

3. The circadian rhythm setting and adjusting apparatus according to claim 1, wherein: A plurality of round holes (5) are formed in the upper end of the cage (1), the plurality of round holes (5) are staggered with the plurality of openings (4), a plurality of cover plates (51) matching the round holes (5) are hingedly connected to the cage (1), fixed columns (52) are fixedly installed on the cover plates (51), the upper end of the cage (1) is provided with positioning members for locking the cover plates (51) in the round holes (5).

4. A circadian rhythm setting and adjustment device according to claim 3, characterized in that: The positioning members comprise a connecting column (53) and a locking block (54), the connecting column (53) is rotatably installed at the upper end of the cage (1), the locking block (54) is rotatably installed on the connecting column (53).

5. The circadian rhythm setting and adjusting apparatus according to claim 1, wherein: A rotating handle (6) is movably mounted at the center of the top of the cage (1).

6. The circadian rhythm setting and adjusting apparatus according to claim 1, wherein: A plurality of storage boxes (7) are fixedly mounted on the side close to the inside of the cage (1) of the fixing cylinder (12), each of the plurality of storage boxes (7) is provided with a partition plate, the storage box (7) is divided into a feeding groove and a water storage groove under the partition of the partition plate, a plurality of feeding holes and perforations are formed in the upper end of the cage (1), the feeding holes are arranged directly above the feeding groove, the perforations are arranged directly above the water storage groove, a water inlet pipe (71) is fixedly inserted into the perforations, and the lower end of the water inlet pipe (71) extends into the water storage groove.

7. The circadian rhythm setting and adjusting apparatus according to claim 1, wherein: A monitoring assembly is arranged outside the cage (1), the monitoring assembly comprises a C-shaped seat (8), a plurality of supporting rods (81), a mounting frame (82), a sleep monitor (83) and a camera (84), the plurality of supporting rods (81) are fixedly mounted on the C-shaped seat (8), the mounting frame (82) is movably mounted on the plurality of supporting rods (81), the sleep monitor (83) and the camera (84) are movably mounted on the mounting frame (82), a lead wire is connected to the signal input end of the sleep monitor (83), the top of the cage (1) and the cover plate (51) are made of transparent material, and the cover plate (51) is provided with a gap slot through which the lead wire can pass.

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