Composite high-low temperature cold and hot ablation system and control method thereof

Abstract

The present invention relates to a composite high-low temperature cold and hot ablation system and a control method thereof, and relates to the field of ablation technology. The composite high-low temperature cold and hot ablation system of the present invention comprises a working fluid storage tank, a phase separation valve, a connecting pipeline, an ablation needle and a controller, wherein the connecting pipeline is used to connect with the working fluid storage tank, the phase separation valve and the ablation needle, and the controller is respectively connected to the working fluid storage tank, the phase separation valve and the ablation needle. The controller is configured to adjust the pressure of the working fluid storage tank according to the number of the ablation needles connected in the connecting pipeline and the diameter of the ablation needles connected in the connecting pipeline, and / or adjust the opening of the phase separation valve so that the phase separation valve is maintained at the target temperature.

Description

Technical Field

[0001] The present invention relates to the technical field of ablation, and in particular to a composite high-low temperature cold and hot ablation system and a control method thereof. Background Art

[0002] The composite high-low temperature cold and hot ablation system can generally include a working fluid storage tank, a connecting pipeline and an ablation needle. After the composite high-low temperature cold and hot ablation system is precooled, the working fluid in the working fluid storage tank can be transported to the ablation needle through the connecting pipeline, and the ablation needle can perform the ablation operation. Since the number of ablation needles connected in the connecting pipeline and the diameter of the ablation needle will affect the flow of the working fluid in the ablation needle, and then affect the temperature of the working fluid, the time required for precooling and ablation operations, the consumption of working fluid and the effect of the ablation operation are completely different. Summary of the invention

[0003] The present invention provides a composite high-low temperature cold and hot ablation system and a control method thereof, which can achieve the purpose of rapid cooling in a manner that saves the most consumption of working fluid under various combinations of ablation needles.

[0004] According to a first aspect of the present invention, the present invention provides a composite high-low temperature cold and hot ablation system, comprising a working fluid storage tank, a phase separation valve, a connecting pipeline, an ablation needle and a controller, wherein the connecting pipeline is used to connect with the working fluid storage tank, the phase separation valve and the ablation needle, and the controller is respectively connected with the working fluid storage tank, the phase separation valve and the ablation needle;

[0005] Wherein, the controller is configured to adjust the pressure of the working fluid storage tank according to the number of the ablation needles connected in the connecting pipeline and the diameters of the ablation needles connected in the connecting pipeline.

[0006] In one embodiment, the controller is configured to: when the number of the ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is ≥ d 1; or when the number of the ablation needles connected in the connecting pipeline is ≥ 2 and the diameter of the ablation needle is ≥ d 2, the controller controls the boost valve and / or the air release valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 1.

[0007] In one embodiment, the controller is configured to: P 1-Δ P 2, the controller controls the boost valve to be fully opened and controls the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 1-Δ P 2 to P 1+ΔP 2, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 1+Δ P 2, the controller controls the air release valve to gradually open; when the pressure of the working fluid storage tank is less than P 1-Δ P 1, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 1;

[0008] Among them, Δ P 1<Δ P 2.

[0009] In one embodiment, the controller is configured to: when the number of the ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is d 2 and d 1, or when the number of the ablation needles connected in the connecting pipeline is ≥ 2 and the diameter of the ablation needle is < d 2, the controller controls the boost valve and / or the air release valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 2;

[0010] in, P 1< P 2.

[0011] In one embodiment, the controller is configured to: P 2-Δ P 2, the controller controls the boost valve to be fully opened and controls the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 2-Δ P 2 to P 2+Δ P 2, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 2-Δ P 2, the controller controls the air release valve to gradually open; when the pressure of the working fluid storage tank is less than P 2-Δ P 1, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 2;

[0012] Among them, Δ P 1<Δ P 2.

[0013] In one embodiment, the controller is configured to: when the number of the ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is less than d 2, the controller adjusts the pressure of the working fluid storage tank to P 3;

[0014] Wherein, when the pressure of the working fluid storage tank is less than P 3-2Δ P 2, control the boost valve to be fully opened and control the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 3-3Δ P 2 to P 3-Δ P 2, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 3-Δ P 2, the controller controls the air release valve to open gradually; when the pressure of the working fluid storage tank is less than P 3-Δ P 3, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 2;

[0015] in, P 1< P 2< P 3; Δ P 1<Δ P 2<Δ P 3.

[0016] In one embodiment, the controller is configured to, when the number of the ablation needles connected in the connecting pipeline is 0, control the boost valve and / or the deflation valve on the working fluid storage tank to increase the pressure of the working fluid storage tank from P 3 Adjust to P 1-Δ P 2;

[0017] Wherein, when the pressure of the working fluid storage tank is less than P 1-2Δ P 2, control the boost valve to be fully opened and control the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 1-2Δ P 2 to P 1, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 1, the controller controls the air release valve to open gradually; when the pressure of the working fluid storage tank is less than P 1-Δ P3, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 1-Δ P 2;

[0018] Among them, Δ P 1<Δ P 2<Δ P 3< P 1< P 3.

[0019] In one embodiment, P 1 is 650kPa, P 2 is 850kPa, P 3 is 1000 kPa; Δ P 1 is 5Kpa~30kPa, Δ P 2 is 10Kpa~50kPa, Δ P 3 is 30kPa~80kPa.

[0020] According to a second aspect of the present invention, the present invention provides a composite high-low temperature cold and hot ablation system, comprising a working fluid storage tank, a phase separation valve, a connecting pipeline, an ablation needle and a controller, wherein the connecting pipeline is used to connect with the working fluid storage tank, the phase separation valve and the ablation needle, and the controller is respectively connected with the working fluid storage tank, the phase separation valve and the ablation needle;

[0021] The controller is configured to adjust the opening of the phase separation valve according to the number of the ablation needles connected in the connecting pipeline and the diameter of the ablation needles connected in the connecting pipeline so that the phase separation valve is maintained at a target temperature.

[0022] In one embodiment, the controller is configured to: when the number of the ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is less than d 2, the controller adjusts the opening of the phase separation valve to keep the phase separation valve at the target temperature, and the target temperature of the phase separation valve is T 1 to T 2;

[0023] Wherein, when the current temperature of the phase separation valve ≥ T 2, the controller adjusts the opening of the phase separation valve to 100%;

[0024] when T 1≤Current temperature of the phase separation valve< T 2, the controller adjusts the opening of the phase separation valve to K 1;

[0025] When the current temperature of the phase separation valve is less thanT 1, the controller adjusts the opening of the phase separation valve to 0%, wherein, T 1< T 2;

[0026] in, K 1 satisfies the following expression:

[0027]

[0028] k is a constant whose value range is 1≤ k ≤1.2.

[0029] In one embodiment, when the number of the ablation needles connected in the connecting pipeline is ≥2 and the diameter of the ablation needle is < d 2, the controller adjusts the opening of the phase separation valve to keep the phase separation valve at the target temperature, and the target temperature of the phase separation valve is T 2 to T 3;

[0030] Wherein, when the current temperature of the phase separation valve ≥ T At 3, the controller adjusts the opening of the phase separation valve to 100%;

[0031] when T 2≤Current temperature of the phase separation valve< T 3, the controller adjusts the opening of the phase separation valve to K 2;

[0032] When the current temperature of the phase separation valve is less than T 2, the controller adjusts the opening of the phase separation valve to 0%, wherein, T 2< T 3;

[0033] in, K 2 satisfies the following expression:

[0034]

[0035] k is a constant whose value range is 1≤ k ≤1.2;

[0036] In one embodiment, the controller is configured to: when the number of the ablation needles connected in the connecting line is 0, or when the number of the ablation needles connected in the connecting line is ≥ 1 and the diameter of the ablation needle is ≥ d 2, the controller adjusts the opening of the phase separation valve to keep the phase separation valve at the target temperature, and the target temperature of the phase separation valve isT 3 to T 4;

[0037] Wherein, when the current temperature of the phase separation valve ≥ T At 5, the controller adjusts the opening of the phase separation valve to 100%;

[0038] when T 4≤Current temperature of the phase separation valve< T 5, the controller adjusts the opening of the phase separation valve to K 3.

[0039] when T 3≤Current temperature of the phase separation valve< T 4, the controller adjusts the opening of the phase separation valve to K 4, among which, K 4> K 3;

[0040] When the current temperature of the phase separation valve ≤ T 3, the controller adjusts the opening of the phase separation valve to 0%, wherein, T 3< T 4< T 5

[0041] in, k is a constant whose value range is 1≤ k ≤1.2.

[0042] In one embodiment, K 3 and K 4 respectively satisfy the following expressions:

[0043] ;

[0044] .

[0045] In one embodiment, T 1 is -15℃, T 2 is -10℃.

[0046] In one embodiment, T 3 is -5℃, T 4 is 0℃, T 5 is 10℃.

[0047] According to a third aspect of the present invention, the present invention provides a control method for composite high-low temperature cold and hot ablation, the control method is applied to the composite high-low temperature cold and hot ablation system, the control method comprises the following steps:

[0048] 100: Determine whether the number of ablation needles connected in the connecting pipeline is 0, if yes, execute step 200, if no, execute step 300;

[0049] 200: Increase the pressure of the working fluid storage tank from P 3 Adjust to P 1-Δ P 2, and keep the phase separation valve at the target temperature T 3 to T 4;

[0050] 300: Determine whether the number of ablation needles connected in the connecting pipeline is 1, if yes, execute step 400, if no, execute step 500;

[0051] 400: Determine whether the diameter of the ablation needle connected in the connecting pipeline is ≥ d 1. If yes, adjust the pressure of the working fluid storage tank to P 1, and keep the phase separation valve at the target temperature T 3 to T 4. If not, execute step 401;

[0052] 401: Determine whether the diameter of the ablation needle connected to the connecting pipeline is within d 2 and d 1, if so, adjust the pressure of the working fluid storage tank to P 2, and keep the phase separation valve at the target temperature T 3 to T 4. If not, execute step 402;

[0053] 402: Determine whether the diameter of the ablation needle connected in the connecting pipeline is less than d 2. If yes, adjust the pressure of the working fluid storage tank to P 3, and keep the phase separation valve at the target temperature T 1 to T 2;

[0054] 500: Determine whether the diameter of the ablation needle connected in the connecting pipeline is ≥ d 2. If yes, adjust the pressure of the working fluid storage tank to P 1, and keep the phase separation valve at the target temperature T 3 to T 4. If not, execute step 501;

[0055] 501: Determine whether the diameter of the ablation needle connected in the connecting pipeline is less than d 2. If yes, adjust the pressure of the working fluid storage tank to P 2, and keep the phase separation valve at the target temperature T 2 to T 3;

[0056] Among them, Δ P 2< P 1< P 2< P 3; T 1< T 2< T 3< T 4.

[0057] Compared with the prior art, the advantage of the present invention is that the controller adjusts the pressure of the working fluid storage tank according to the number and diameter of the ablation needles connected in the connecting pipeline, and / or adjusts the opening of the phase separation valve so that the phase separation valve is maintained at the target temperature, thereby achieving the purpose of rapid cooling in a manner that saves the most working fluid consumption under various combinations of ablation needles. BRIEF DESCRIPTION OF THE DRAWINGS

[0058] Hereinafter, the present invention will be described in more detail based on embodiments and with reference to the accompanying drawings.

[0059] Figure 1 is a flow chart of a control method of a composite high-low temperature cold and hot ablation system in an embodiment of the present invention;

[0060] Figure 2 yes Figure 1 Flowchart of step 200;

[0061] Figure 3 yes Figure 1 Flow chart of step 403;

[0062] Figure 4 yes Figure 1 Flowchart of step 404;

[0063] Figure 5 yes Figure 1 Flowchart of step 405;

[0064] Figure 6 yes Figure 1 Flowchart of step 502 in FIG. DETAILED DESCRIPTION

[0065] The present invention will be further described below in conjunction with the accompanying drawings.

[0066] The present invention provides a composite high-low temperature cold and hot ablation system, including a working fluid storage tank, a phase separation valve, a connecting pipeline, an ablation needle and a controller. The connecting pipeline is used to connect with the working fluid storage tank, the phase separation valve and the ablation needle, and the controller is respectively connected with the working fluid storage tank, the phase separation valve and the ablation needle.

[0067] The working fluid storage tank of the present invention can be, for example, a cold tank for storing cold working fluids such as liquid nitrogen, and its structure can adopt various implementation methods in the prior art. Similarly, the phase separation valve, connecting pipeline and ablation needle can all adopt various implementation methods in the prior art.

[0068] The controller of the present invention is configured to adjust the pressure of the working fluid storage tank according to the number of ablation needles connected in the connecting pipeline and the diameters of the ablation needles connected in the connecting pipeline.

[0069] The idea of ​​the present invention is to design different thresholds according to different ablation needle diameters and number combinations, so as to achieve the purpose of rapid cooling in a way that saves the most working fluid (such as liquid nitrogen) regardless of how the ablation needles are used in combination. Specifically, when the number of ablation needles connected in the connecting pipeline is 1, it is divided into the following three situations.

[0070] The first case is: the number of ablation needles connected in the connecting tube is 1 and the diameter of the ablation needle is ≥ d 1. Among them, d 1 For example, it can be 2.6 mm, and the diameter of the ablation needle connected in the connecting tube ≥ d 1 means that the diameter of the ablation needle connected in the connecting tube may be 2.6 mm or larger.

[0071] It should be noted that the diameter of the ablation needle refers to the diameter at the exit of the needle tip of the ablation needle.

[0072] In the first case, the controller is configured to control the boost valve and / or the vent valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 1.

[0073] The controller controls the opening or closing of the boost valve on the working fluid storage tank, or controls the gradual opening or closing of the air release valve on the working fluid storage tank, so as to achieve the purpose of adjusting the pressure (working pressure) of the working fluid storage tank. The boost valve and the air release valve can be electrically connected to the controller, for example, and the controller is configured to send relevant instructions to the boost valve or the air release valve, so that the relevant components on the boost valve or the air release valve perform corresponding actions, thereby adjusting the opening of the boost valve or the air release valve, for example, fully opening the boost valve or the air release valve (i.e., the opening is 100%), fully closing the boost valve or the air release valve (i.e., the opening is 0%), etc.

[0074] For example, in the first case, the controller is configured to P 1-Δ P 2, the controller controls the boost valve to fully open and controls the vent valve to fully close; when the pressure of the working fluid storage tank is P 1-Δ P 2 to P 1+ΔP 2, the controller controls the boost valve to close gradually (the vent valve is completely closed at this time); when the pressure of the working fluid storage tank is greater than P 1+Δ P 2, the controller controls the vent valve to open gradually; when the pressure of the working fluid storage tank is less than P 1-Δ P 1, the controller controls the vent valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 1; where Δ P 1<Δ P 2.

[0075] More specifically, P 1 can be 650 kPa, for example, P 2 For example, it can be 850 kPa, Δ P The value range of 1 can be, for example, 5KPa~30kPa, Δ P The value range of 2 can be, for example, 10KPa~50kPa. P 1 and Δ P The smaller the value of 2, the higher the adjustment accuracy. P 1 is 30 kPa, Δ P 2 is 50 kPa; or alternatively, Δ P 1 is 10 kPa, Δ P 2 is 30 kPa; or alternatively, Δ P 1 is 5Kpa, Δ P 2 is 10KPa. In the first case, the target pressure of the working fluid storage tank is 650kPa. Under this target pressure, the temperature fed back by the phase separation valve can reach the target temperature within 10 minutes, which is much shorter than the preparation time before the ablation operation, thereby improving the efficiency of the ablation operation.

[0076] In the following, Δ P 1 is 30 kPa, Δ P 2 is 50 kPa as an example for explanation.

[0077] Understandably, in the first case, the target pressure is P 1 (650kPa), P 1-Δ P 2 is 600 kPa, P 1+Δ P 2 is 700 kPa, P 1-Δ P 1 is 620kPa.

[0078] When the pressure of the working fluid storage tank is less than 600kPa, the controller controls the boost valve to be fully opened and controls the air release valve to be fully closed. At this time, the working fluid storage tank can be pressurized to increase its pressure; when the pressure of the working fluid storage tank is between 600kPa-700kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 700kPa, the controller controls the air release valve to be gradually opened. At this time, the working fluid storage tank can be depressurized to reduce its pressure; when the pressure of the working fluid storage tank is less than 620Pa, the controller controls the air release valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 650kPa.

[0079] In the above adjustment process, if the pressure of the working fluid storage tank is between 600kPa-700kPa, it means that it is close to the target pressure, so the controller can control the boost valve to close gradually so as to gradually approach the target temperature. In other words, when adjusting the pressure of the working fluid storage tank, the pressure of the working fluid storage tank is not directly compared with the target pressure, but its pressure is compared with the lower limit value (e.g. 600kPa) and the upper limit value (e.g. 700kPa) of the range where the target pressure is located. In this way, considering that both boosting and depressurizing require a certain amount of time, it can ensure that the pressure of the working fluid storage tank gradually approaches the target temperature, and the boost valve or the air release valve will not be frequently opened / closed to cause system disorder.

[0080] The second case is: the number of ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is d 2 and d 1. Among them, d 2 For example, it can be 2 mm. The diameter of the ablation needle connected in the connecting tube is d 2 and d 1 indicates that the diameter of the ablation needle connected in the connecting pipeline may be 2mm or 2.5mm, etc.

[0081] In the second case, the controller is configured to control the boost valve and / or the vent valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 2, among which, P 1< P 2.

[0082] The controller controls the opening or closing of the boost valve on the working fluid storage tank, or controls the gradual opening or closing of the vent valve on the working fluid storage tank, thereby achieving the purpose of regulating the pressure (working pressure) of the working fluid storage tank.

[0083] For example, in the second case, the controller is configured to P 2-Δ P2, control the boost valve to fully open, and control the vent valve to fully close; when the pressure of the working fluid storage tank is P 2-Δ P 2 to P 2+Δ P 2, the boost valve is controlled to close gradually; when the pressure of the working fluid storage tank is greater than P 2-Δ P 2, the control vent valve is gradually opened; when the pressure of the working fluid storage tank is less than P 2-Δ P 1, the air release valve is controlled to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 2; where Δ P 1<Δ P 2.

[0084] More specifically, d 2 can be 2 mm, for example. P 2 For example, it can be 850kPa.

[0085] Understandably, in the second case, the target pressure is P 2 (850 kPa), P 2-Δ P 2 is 800 kPa, P 2+Δ P 2 is 900 kPa, P 2-Δ P 1 is 820kPa.

[0086] That is to say, in the second case, the target pressure of the working fluid storage tank is 850kPa. When the pressure of the working fluid storage tank is less than 800kPa, the controller controls the boost valve to be fully opened and controls the bleed valve to be fully closed. At this time, the working fluid storage tank can be pressurized to increase its pressure; when the pressure of the working fluid storage tank is between 800kPa-900kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 800kPa, the controller controls the bleed valve to be gradually opened. At this time, the working fluid storage tank can be depressurized to reduce its pressure; when the pressure of the working fluid storage tank is less than 820Pa, the controller controls the bleed valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 850kPa.

[0087] In the above adjustment process, if the pressure of the working fluid storage tank is between 800kPa and 900kPa, it means that it is close to the target pressure, so the controller can control the boost valve to close gradually so as to gradually approach the target temperature. In other words, when adjusting the pressure of the working fluid storage tank, the pressure of the working fluid storage tank is not directly compared with the target pressure, but its pressure is compared with the lower limit value (e.g. 800kPa) and the upper limit value (e.g. 900kPa) of the range where the target pressure is located. In this way, considering that both boosting and depressurizing require a certain amount of time, it can ensure that the pressure of the working fluid storage tank gradually approaches the target temperature, and the boost valve or the air release valve will not be frequently opened / closed to cause system disorder.

[0088] The third case is: the number of ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is less than d 2. Among them, d 2 For example, it can be 2 mm, and the diameter of the ablation needle connected in the connecting tube is < d 2 means that the diameter of the ablation needle connected in the connecting tube may be 1.7 mm.

[0089] In the third case above, the controller adjusts the pressure of the working fluid storage tank to P 3.

[0090] The controller controls the opening or closing of the boost valve on the working fluid storage tank, or controls the gradual opening or closing of the vent valve on the working fluid storage tank, thereby achieving the purpose of regulating the pressure (working pressure) of the working fluid storage tank.

[0091] For example, in the third case, when the pressure of the working fluid storage tank is less than P 3-2Δ P 2, control the boost valve to fully open and control the vent valve to fully close; when the pressure of the working fluid storage tank is P 3-3Δ P 2 to P 3-Δ P 2, the boost valve is controlled to close gradually; when the pressure of the working fluid storage tank is greater than P 3-Δ P 2, the control vent valve is gradually opened; when the pressure of the working fluid storage tank is less than P 3-Δ P 3, the air release valve is controlled to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 2; among them, P 1< P 2< P 3; Δ P 1<Δ P 2<Δ P 3.

[0092] More specifically, P 3 For example, it can be 1000 kPa, Δ P The value range of Δ 3 may be, for example, 30 kPa to 80 kPa. P 3 is 80 kPa, Δ P 3 is 50 kPa; or Δ P 3 is 30kPa.

[0093] That is to say, in the third case, the target pressure of the working fluid storage tank is 1000kPa. When the pressure of the working fluid storage tank is less than 900kPa, the controller controls the boost valve to be fully opened and controls the bleed valve to be fully closed. At this time, the working fluid storage tank can be pressurized to increase its pressure; when the pressure of the working fluid storage tank is between 850kPa-950kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 950kPa, the controller controls the bleed valve to be gradually opened. At this time, the working fluid storage tank can be depressurized to reduce its pressure; when the pressure of the working fluid storage tank is less than 920Pa, the controller controls the bleed valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 1000kPa.

[0094] In the above adjustment process, since the maximum pressure of the working fluid storage tank is set to 1000 kPa, the lower limit value of the range of its target pressure may be 850 kPa, and the upper limit value (not exceeding the maximum pressure) may be 950 kPa.

[0095] Similarly, if the pressure of the working fluid storage tank is between 850kPa and 950kPa, it indicates that it is close to the target pressure, so the controller can control the boost valve to gradually close so as to gradually approach the target temperature. In other words, when adjusting the pressure of the working fluid storage tank, the pressure of the working fluid storage tank is not directly compared with the target pressure, but its pressure is compared with the lower limit value (e.g. 850kPa) and the upper limit value (e.g. 950kPa) of the range where the target pressure is located. In this way, considering that both boosting and depressurizing require a certain amount of time, the pressure of the working fluid storage tank can be ensured to gradually approach the target temperature, and the boost valve or the air release valve will not be frequently opened / closed to cause system disorder.

[0096] According to the first, second and third cases mentioned above, when the number of ablation needles connected in the connecting pipeline is the same, the smaller the diameter of the ablation needle, the higher the pressure of the working fluid storage tank needs to be adjusted to ensure that the temperature of the cold working fluid at the outlet of the needle tip of each diameter of the ablation needle can meet the treatment temperature requirements.

[0097] In addition, when the number of ablation needles connected in the connecting pipeline is greater than or equal to 2, it is divided into the following fourth case and fifth case.

[0098] The fourth case is: the number of ablation needles connected in the connecting tube is ≥ 2 and the diameter of the ablation needle is ≥ d 2. In the fourth case, the controller is configured to control the boost valve and / or the vent valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 1.

[0099] For the fourth case, the controller can use the same control method as in the first case to adjust the pressure of the working fluid storage tank to P 1, the present invention will not go into details here.

[0100] The fifth case is: when the number of ablation needles connected in the connecting pipeline is ≥ 2 and the diameter of the ablation needle is < d 2, the controller controls the boost valve and / or the air release valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 2; among them, P 1< P 2.

[0101] For the fifth case, the controller can use the same control method as in the second case to adjust the pressure of the working fluid storage tank to P 2, the present invention will not go into details therein.

[0102] According to the fourth and fifth cases mentioned above, when the number of ablation needles connected in the connecting pipeline is the same, the smaller the diameter of the ablation needle, the higher the pressure of the working fluid storage tank needs to be adjusted to ensure that the temperature of the cold working fluid at the outlet of the needle tip of each diameter of the ablation needle can meet the treatment temperature requirements.

[0103] In addition, for the case where the number of ablation needles connected in the connecting pipeline is 0, that is, the sixth case, the control method of the controller is as follows.

[0104] The controller is configured such that, when the number of ablation needles connected in the connecting pipeline is 0, the controller controls the boost valve and / or the deflation valve on the working fluid storage tank, thereby increasing the pressure of the working fluid storage tank from P 3 Adjust to P 1-Δ P 2, that is, the target pressure is P 1-Δ P 2. When the number of ablation needles connected in the connecting pipeline is 0, that is, no ablation needle is connected, it indicates that the preparation work before the ablation operation is in progress. Therefore, in this case, the pressure of the working fluid storage tank can be adjusted to a smaller pressure range to avoid the waste of working fluid (liquid nitrogen).

[0105] Among them, when the pressure of the working fluid storage tank is less than P 1-2Δ P2, control the boost valve to fully open and control the vent valve to fully close; when the pressure of the working fluid storage tank is P 1-2Δ P 2 to P 1, the boost valve is controlled to close gradually (the vent valve is completely closed at this time); when the pressure of the working fluid storage tank is greater than P 1, the control vent valve is gradually opened; when the pressure of the working fluid storage tank is less than P 1-Δ P 3, the air release valve is controlled to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 1-2Δ P 2. Among them, Δ P 1<Δ P 2<Δ P 3< P 1< P 3.

[0106] Understandably, in the sixth case, the target pressure is P 1-Δ P 2 (600 kPa), P 1-2Δ P 2 is 550 kPa, P 1-Δ P 3 is 570kPa.

[0107] More specifically, in the sixth case, since the ablation needle is not connected to the connecting pipeline, it means that the ablation operation is not performed at this time, but a pre-cooling operation is performed. Therefore, in the pre-cooling operation, it is necessary to control the target pressure of the working fluid storage tank to be smaller, so as to achieve the purpose of reducing liquid nitrogen consumption.

[0108] That is to say, in the sixth case, the target pressure of the working fluid storage tank is 600kPa. When the pressure of the working fluid storage tank is less than 550kPa, the controller controls the boost valve to be fully opened and controls the air release valve to be fully closed. At this time, the working fluid storage tank can be pressurized to increase its pressure; when the pressure of the working fluid storage tank is between 550kPa-650kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 650kPa, the controller controls the air release valve to be gradually opened. At this time, the working fluid storage tank can be depressurized to reduce its pressure; when the pressure of the working fluid storage tank is less than 570kPa, the controller controls the air release valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 600kPa.

[0109] In the above adjustment process, if the pressure of the working fluid storage tank is between 550kPa-650kPa, it means that it is close to the target pressure, so the controller can control the boost valve to close gradually so as to gradually approach the target temperature. In other words, when adjusting the pressure of the working fluid storage tank, the pressure of the working fluid storage tank is not directly compared with the target pressure, but its pressure is compared with the lower limit value (e.g. 550kPa) and the upper limit value (e.g. 650kPa) of the range where the target pressure is located. In this way, considering that both boosting and depressurizing require a certain amount of time, it can ensure that the pressure of the working fluid storage tank gradually approaches the target temperature, and the boost valve or the air release valve will not be frequently opened / closed to cause system disorder.

[0110] In all the above cases, the controller controls the opening and closing of the boost valve and the bleed valve through PID regulation, so that the pressure of the working fluid storage tank can gradually approach the target temperature. For example, controlling the boost valve to close gradually or controlling the bleed valve to open gradually can be achieved by PID regulating the opening of the boost valve or the opening of the bleed valve. For example, the opening of the boost valve is adjusted from 100% to 80%, then to 10%, and finally to 0%; or the opening of the bleed valve is adjusted from 0% to 20%, then to 70%, and finally to 100%.

[0111] In the above-mentioned cases, the working fluid storage tank is provided with a pressure detection device for detecting its pressure, such as a pressure sensor, etc. The pressure detection device is electrically connected to the controller, so that the pressure detection device can feed back the pressure of the working fluid storage tank to the controller, and the controller adopts the corresponding control strategy described above according to the pressure of the working fluid storage tank fed back by the pressure detection device.

[0112] In the second aspect of the present invention, the present invention provides a composite high and low temperature hot and cold ablation system, including a working fluid storage tank, a phase separation valve, a connecting pipeline, an ablation needle and a controller. The connecting pipeline is used to connect with the working fluid storage tank, the phase separation valve and the ablation needle, and the controller is respectively connected to the working fluid storage tank, the phase separation valve and the ablation needle.

[0113] The working fluid storage tank of the present invention can be, for example, a cold tank for storing cold working fluids such as liquid nitrogen, and its structure can adopt various implementation methods in the prior art. Similarly, the phase separation valve, connecting pipeline and ablation needle can all adopt various implementation methods in the prior art.

[0114] The controller of the present invention is configured to adjust the opening of the phase separation valve according to the number of the ablation needles connected in the connecting pipeline and the diameter of the ablation needles connected in the connecting pipeline so that the phase separation valve is maintained at the target temperature. The phase separation valve can be electrically connected to the controller, for example, and the controller is configured to send relevant instructions to the phase separation valve so that the relevant components on the phase separation valve perform corresponding actions, thereby adjusting the opening of the phase separation valve, for example, making the opening of the phase separation valve 100% or 0%, etc.

[0115] The concept of the present invention is to design different thresholds according to different ablation needle diameters and quantity combinations, so as to achieve the purpose of rapid cooling in the most liquid nitrogen-saving manner regardless of how the ablation needles are combined and used.

[0116] Specifically, when the number of ablation needles connected in the connecting pipeline is 1, it is divided into the following three cases.

[0117] The first case is: the number of ablation needles connected in the connecting tube is 1 and the diameter of the ablation needle is ≥ d 1, where d 1 For example, it can be 2.6 mm, and the diameter of the ablation needle connected in the connecting tube ≥ d 1 means that the diameter of the ablation needle connected in the connecting tube may be 2.6 mm or larger.

[0118] In the first case, the controller is configured to open the phase separation valve so that the phase separation valve is maintained at the target temperature. T 3 to T 4.

[0119] Specifically, when the current temperature of the phase separation valve ≥ T 5, the controller adjusts the opening of the phase separation valve to 100%; when T 4≤Current temperature of phase separation valve< T 5, the controller adjusts the opening of the phase separation valve to K 3. When T 3≤Current temperature of phase separation valve< T 4, the controller adjusts the opening of the phase separation valve to K 4, among which, K 4> K 3. When the current temperature of the phase separation valve ≤ T At 3, the controller adjusts the opening of the phase separation valve to 0%, where T 3< T 4< T 5.

[0120] K 3 and K 4 respectively satisfy the following expressions:

[0121] ;

[0122] .

[0123] in, k is a constant whose value range is 1≤ k ≤1.2.

[0124] k The value of is an empirical constant summarized and verified based on experimental results, and k The value of is related to the pressure of the working fluid storage tank and the number of ablation needles connected in the connecting pipeline. In the first case, the pressure of the working fluid storage tank is P 1 (650 kPa), the number of ablation needles connected in the connecting pipeline is 1, so the controller adjustment degree needs to be larger, so that the phase separation valve can be adjusted to the target temperature faster, thereby k is closer to its maximum value. Therefore, in the first case, k The value of can be 1.15.

[0125] More specifically, T 3 is -5℃, T 4 is 0℃, T 5 is 10° C. It can be understood that in the first case, the controller is configured to adjust the opening of the phase separation valve so that the phase separation valve is maintained at the target temperature of -5° C. to 0° C.

[0126] in, T 3 When the temperature is -5℃, the flow rate of the phase separation valve is 15 L / min -18 L / min; T 4 When the temperature is 0℃, the flow rate of the phase separation valve is 10 L / min -14 L / min; T 5 is 10℃, and the flow rate of the phase separation valve is 8 L / min ~10 L / min, which can ensure that the consumption of liquid nitrogen is small.

[0127] Therefore, the controller specifically adjusts the opening of the phase separation valve as follows:

[0128] When the current temperature of the phase separation valve is ≥10℃, the controller adjusts the opening of the phase separation valve to 100%; when 0℃≤the current temperature of the phase separation valve<10℃, the controller adjusts the opening of the phase separation valve to K 3. When -5℃≤the current temperature of the phase separation valve<0℃, the controller adjusts the opening of the phase separation valve to K 4, among which, K 4> K 3. When the current temperature of the phase separation valve is ≤-5°C, the controller adjusts the opening of the phase separation valve to 0%.

[0129] K 3 satisfies the following expression:

[0130] ;

[0131] K 4 respectively satisfy the following expressions:

[0132] .

[0133] The second case is: the number of ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is d 2 and d 1. Among them, d 2 For example, it can be 2 mm. The diameter of the ablation needle connected in the connecting tube is d 2 and d 1 indicates that the diameter of the ablation needle connected in the connecting pipeline may be 2mm or 2.5mm, etc.

[0134] In the second case, the controller adjusts the opening of the phase separation valve to keep the phase separation valve at the target temperature. The target temperature of the phase separation valve is T 3 to T 4. It can be understood that, in the second case above, the controller is configured to adjust the opening of the phase separation valve so that the phase separation valve is maintained at a target temperature of -5°C to 0°C.

[0135] For the second case, the controller can use the same control method as in the first case to adjust the opening of the phase separation valve to keep the phase separation valve at the target temperature. The target temperature of the phase separation valve is T 3 to T 4, the present invention will not go into details here.

[0136] The third case is: the number of ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is less than d 2. Among them, d 2 For example, it can be 2 mm, and the diameter of the ablation needle connected in the connecting tube is < d 2 means that the diameter of the ablation needle connected in the connecting tube may be 1.7 mm.

[0137] In the third case, the controller is configured to adjust the opening of the phase separation valve to maintain the phase separation valve at a target temperature. The target temperature of the phase separation valve is T 1 to T 2.

[0138] Specifically, when the current temperature of the phase separation valve ≥ T 2, the controller adjusts the opening of the phase separation valve to 100%; when T 1≤Current temperature of phase separation valve< T2, the controller adjusts the opening of the phase separation valve to K 1; When the current temperature of the phase separation valve is less than T 1, the controller adjusts the opening of the phase separation valve to 0%, where T 1< T 2; among them, K 1 satisfies the following expression:

[0139]

[0140] k is a constant whose value range is 1≤ k ≤1.2.

[0141] k The value of is an empirical constant summarized and verified based on experimental results, and k The value of is related to the pressure of the working fluid storage tank and the number of ablation needles connected in the connecting pipeline. In the third case, the pressure of the working fluid storage tank is P 3 (1000 kPa), the number of ablation needles connected in the connecting pipeline is 1, so the degree of controller adjustment can be slightly smaller than that in the first case. k The value of can be 1.12.

[0142] More specifically, T 1 For example, it can be -15°C, T 2 may be, for example, -10°C. It can be understood that, in the third case above, the controller is configured to adjust the opening of the phase separation valve so that the phase separation valve is maintained at a target temperature of -15°C to -10°C.

[0143] Therefore, the controller specifically adjusts the opening of the phase separation valve as follows:

[0144] When the current temperature of the phase separation valve is ≥-10℃, the controller adjusts the opening of the phase separation valve to 100%; when -15℃≤the current temperature of the phase separation valve<-10℃, the controller adjusts the opening of the phase separation valve to K 1; When the current temperature of the phase separation valve is less than -15°C, the controller adjusts the opening of the phase separation valve to 0%, wherein, T 1< T 2; among them, K 1 satisfies the following expression:

[0145]

[0146] In addition, when the number of ablation needles connected in the connecting pipeline is greater than or equal to 2, it is divided into the following fourth case and fifth case.

[0147] The fourth case is: the number of ablation needles connected in the connecting tube is ≥ 2 and the diameter of the ablation needle is ≥ d 2. In the fourth case, the controller adjusts the opening of the phase separation valve to keep the phase separation valve at the target temperature. The target temperature of the phase separation valve is T 3 to T 4. It can be understood that, in the second case above, the controller is configured to adjust the opening of the phase separation valve so that the phase separation valve is maintained at a target temperature of -5°C to 0°C.

[0148] For the fourth case, the controller can use the same control method as in the first case to adjust the opening of the phase separation valve to keep the phase separation valve at the target temperature. The target temperature of the phase separation valve is T 3 to T 4, the present invention will not go into details here.

[0149] Furthermore, the fifth situation is: when the number of ablation needles connected in the connecting pipeline is ≥ 2 and the diameter of the ablation needle is < d 2.

[0150] In the fifth case, the controller adjusts the opening of the phase separation valve to keep the phase separation valve at the target temperature. The target temperature of the phase separation valve is T 2 to T 3. It can be understood that, in the fifth case, the controller is configured to adjust the opening of the phase separation valve so that the phase separation valve is maintained at the target temperature of -10°C to -5°C.

[0151] For example, in the fifth case, when the current temperature of the phase separation valve ≥ T 3, the controller adjusts the opening of the phase separation valve to 100%; when T 2≤Current temperature of phase separation valve< T 3, the controller adjusts the opening of the phase separation valve to K 2; When the current temperature of the phase separation valve is less than T 2, the controller adjusts the opening of the phase separation valve to 0%, where T 2< T 3; among them, K 2 satisfies the following expression:

[0152]

[0153] k is a constant whose value range is 1≤ k ≤1.2.

[0154] k The value of is an empirical constant summarized and verified based on experimental results, and kThe value of is related to the pressure of the working fluid storage tank and the number of ablation needles connected in the connecting pipeline. In the fifth case, the pressure of the working fluid storage tank is P 2 (850 kPa), the number of ablation needles connected in the connecting pipeline is 2, so the degree of adjustment of the controller can be smaller than that in the first case. Therefore, in the fifth case, k The value of can be 1.05.

[0155] Therefore, the controller specifically adjusts the opening of the phase separation valve as follows:

[0156] When the current temperature of the phase separation valve is ≥-5℃, the controller adjusts the opening of the phase separation valve to 100%; when -10℃≤the current temperature of the phase separation valve<-5℃, the controller adjusts the opening of the phase separation valve to K 2. When the current temperature of the phase separation valve is less than -10°C, the controller adjusts the opening of the phase separation valve to 0%, wherein: K 2 satisfies the following expression:

[0157]

[0158] In addition, for the case where the number of ablation needles connected in the connecting pipeline is 0, that is, in the sixth case,

[0159] The controller is configured to adjust the opening of the phase separation valve to keep the phase separation valve at a target temperature when the number of ablation needles connected in the connecting pipeline is 0. T 3 to T 4.

[0160] For the sixth case, the controller can use the same control method as in the first case to adjust the opening of the phase separation valve to keep the phase separation valve at the target temperature. The target temperature of the phase separation valve is T 3 to T 4. The present invention will not elaborate on this. It can be understood that in the sixth case, the controller is configured to adjust the opening of the phase separation valve so that the phase separation valve is maintained at a target temperature of -5°C to 0°C.

[0161] It should be noted that the current temperature of the phase separation valve refers to the temperature obtained at the temperature measuring point on the downstream side of the phase separation valve, which is generally the temperature of the gas phase working fluid separated by the phase separation valve (or may also include a small amount of liquid phase working fluid). Therefore, if the current temperature of the phase separation valve is high (for example, greater than 10°C), it means that there is more gas phase in the working fluid at this time, so it is necessary to increase the opening of the phase separation valve to increase the gas velocity of the discharged gas phase.

[0162] In the above cases, kThe value of is related to the pressure of the working fluid storage tank and the number of ablation needles connected in the connecting pipeline. The lower the pressure of the working fluid storage tank, k The larger the value of is, the fewer the number of ablation needles connected in the connecting pipeline is. k The larger the value of . k The larger the value of is, the greater the degree to which the controller adjusts the opening of the phase separation valve, so that feedback adjustment can be performed more quickly according to the phase separation temperature.

[0163] In the above-mentioned cases, a temperature detection device for detecting the temperature of the phase separation valve is provided on the phase separation valve (or in the pipeline downstream thereof), which may be a temperature sensor or a thermocouple, etc. The temperature detection device is electrically connected to the controller, so that the temperature detection device can feed back the temperature of the working fluid storage tank to the controller, and the controller adopts the corresponding control strategy described above according to the temperature of the phase separation valve fed back by the temperature detection device.

[0164] In addition, the controller of the present invention can also be constructed to adjust the pressure of the working fluid storage tank and the opening of the phase separation valve according to the number of ablation needles connected in the connecting pipeline and the diameter of the ablation needles connected in the connecting pipeline, so that the pressure of the working fluid storage tank is maintained near the target pressure and the phase separation valve is maintained at the target temperature.

[0165] In a third aspect of the present invention, the present invention provides a control method for a composite high-low temperature cold and hot ablation system. The control method is applied to the composite high-low temperature cold and hot ablation system, and the control method comprises the following steps:

[0166] Step 100: Determine whether the number of ablation needles connected in the connecting pipeline is 0, if so, execute step 200, if not, execute step 300.

[0167] Specifically, feedback can be provided through the connection device on the ablation needle. For example, when the connecting pipeline is connected to the corresponding ablation needle, it indicates that the two are snapped into place, and the connection device will feedback a signal that the ablation needle is connected to the controller, indicating that the ablation needle is connected in the connecting pipeline; otherwise, it indicates that the ablation needle is not connected in the connecting pipeline.

[0168] Step 200: For the case where the number of ablation needles connected in the connecting pipeline is 0 (corresponding to the sixth case described above), the pressure of the working fluid storage tank is increased from P 3 Adjust to P 1-Δ P 2, and keep the current temperature of the phase separation valve at T 3 to T 4.

[0169] Among them, the pressure of the working fluid storage tank is changed from P 3 Adjust to P1-Δ P 2, and keep the current temperature of the phase separation valve at T 3 to T 4. The control method in the sixth case mentioned above can be adopted.

[0170] Step 300: When the number of ablation needles connected in the connection pipeline is not 0, further determination is required, that is, determining whether the number of ablation needles connected in the connection pipeline is 1, if so, executing step 400, if not, executing step 500.

[0171] Step 400: When the number of ablation needles connected in the connecting line is 1, further judgment is required. That is, whether the diameter of the ablation needles connected in the connecting line is ≥ d 1. If the diameter of the ablation needle connected to the connecting tube is ≥ d 1 (corresponding to the first case mentioned above), then adjust the pressure of the working fluid storage tank to P 1, and keep the current temperature of the phase separation valve at T 3 to T 4 (i.e., step 403); otherwise, step 401 is executed, i.e., further judgment is required.

[0172] Among them, the pressure of the working fluid storage tank is adjusted to P 1, and keep the current temperature of the phase separation valve at T 3 to T 4. The control method in the first case mentioned above can be adopted.

[0173] Step 401: Determine whether the diameter of the ablation needle connected in the connecting pipeline is within d 2 and d 1. If the diameter of the ablation needle connected to the connecting tube is between d 2 and d 1 (corresponding to the second case mentioned above), the pressure of the working fluid storage tank is adjusted to P 2, and keep the current temperature of the phase separation valve at T 3 to T 4 (i.e., step 404); otherwise, execute step 402.

[0174] Among them, the pressure of the working fluid storage tank is adjusted to P 2, and keep the current temperature of the phase separation valve at T 3 to T 4. The control method in the second case mentioned above can be adopted.

[0175] Step 402: Determine whether the diameter of the ablation needle connected in the connecting pipeline is less than d 2. If the diameter of the ablation needle connected in the connecting tube is less than d2 (corresponding to the third case described above), the pressure of the working fluid storage tank is adjusted to P 3, and keep the current temperature of the phase separation valve at T 1 to T 2.

[0176] Among them, the pressure of the working fluid storage tank is adjusted to P 3, and keep the current temperature of the phase separation valve at T 1 to T 2 (ie, step 405), the control method in the third case mentioned above may be adopted.

[0177] 500: If the number of ablation needles connected in the connecting line is ≥ 2, further judgment is required. That is, whether the diameter of the ablation needles connected in the connecting line is ≥ d 2. If the diameter of the ablation needle connected to the connecting tube is ≥ d 2 (corresponding to the fourth case described above), the pressure of the working fluid storage tank is adjusted to P 1, and keep the current temperature of the phase separation valve at T 3 to T 4 (i.e., step 403); otherwise, execute step 501.

[0178] Among them, the pressure of the working fluid storage tank is adjusted to P 1, and keep the current temperature of the phase separation valve at T 3 to T 4. The control method in the fourth case mentioned above can be adopted.

[0179] 501: Determine whether the diameter of the ablation needle connected in the connecting pipeline is less than d 2. If the diameter of the ablation needle connected in the connecting tube is less than d 2 (corresponding to the fifth case described above), the pressure of the working fluid storage tank is adjusted to P 2, and keep the current temperature of the phase separation valve at T 2 to T 3 (i.e., step 502). Where, Δ P 2< P 1< P 2< P 3; T 1< T 2< T 3< T 4.

[0180] Among them, the pressure of the working fluid storage tank is adjusted to P 2, and keep the current temperature of the phase separation valve at T 2 to T 3. The control method in the fifth case mentioned above can be adopted.

[0181] When the precooling operation or the ablation operation is completed, the method can be terminated.

[0182] Example 1

[0183] Connect the disconnected ablation needle in the tubing.

[0184] The target pressure of the working fluid storage tank is 600kPa. When the pressure of the working fluid storage tank is less than 550kPa, the controller controls the boost valve to be fully opened and controls the air release valve to be fully closed; when the pressure of the working fluid storage tank is between 550kPa-650kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 650kPa, the controller controls the air release valve to be gradually opened; when the pressure of the working fluid storage tank is less than 650Pa, the controller controls the air release valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 570kPa.

[0185] During this process, the liquid nitrogen consumption is about 3%, and the duration of the pre-cooling operation of the composite high-low temperature cold and hot ablation system (i.e., the time it takes for the composite high-low temperature cold and hot ablation system to drop to the required temperature) is 6 minutes.

[0186] Therefore, when connecting the ablation needle that is not connected in the pipeline, that is, when the system is precooling, the pressure of the working fluid storage tank is controlled so that the consumption of liquid nitrogen meets the requirement of less than 8% and the precooling time meets the requirement of no more than 8 minutes.

[0187] Example 2

[0188] The number of ablation needles connected in the connecting pipeline is 1.

[0189] The diameter of the ablation needle is 3mm. The target pressure of the working fluid storage tank is 650kPa. When the pressure of the working fluid storage tank is less than 600kPa, the controller controls the boost valve to be fully opened and controls the vent valve to be fully closed; when the pressure of the working fluid storage tank is between 600kPa-700kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 700kPa, the controller controls the vent valve to be gradually opened; when the pressure of the working fluid storage tank is less than 620Pa, the controller controls the vent valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 650kPa.

[0190] When this ablation needle is used for ablation, the liquid nitrogen consumption is about 13%, the ice ball size is about 50mm (short axis size) × 70mm (long axis size), and the ablation operation lasts for 20 minutes. It should be noted that the above ice ball size is measured in a 37°C gelatin environment.

[0191] The diameter of the ablation needle is 2.6mm. The target pressure of the working fluid storage tank is 850kPa. When the pressure of the working fluid storage tank is less than 800kPa, the controller controls the boost valve to be fully opened and controls the vent valve to be fully closed; when the pressure of the working fluid storage tank is between 800kPa-900kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 800kPa, the controller controls the vent valve to be gradually opened; when the pressure of the working fluid storage tank is less than 820Pa, the controller controls the vent valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 850kPa.

[0192] When this ablation needle is used for ablation, the liquid nitrogen consumption is about 15%, the ice ball size is about 43mm (short axis size) × 52mm (long axis size), and the ablation operation lasts for 20 minutes. It should be noted that the above ice ball size is measured in a 37°C gelatin environment.

[0193] The diameter of the ablation needle is 1.7mm. The target pressure of the working fluid storage tank is 1000kPa. When the pressure of the working fluid storage tank is less than 900kPa, the controller controls the boost valve to be fully opened and controls the vent valve to be fully closed; when the pressure of the working fluid storage tank is between 850kPa-950kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 950kPa, the controller controls the vent valve to be gradually opened; when the pressure of the working fluid storage tank is less than 920Pa, the controller controls the vent valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 1000kPa.

[0194] When this ablation needle is used for ablation, the liquid nitrogen consumption is about 17%, the ice ball size is about 28mm (short axis size) × 32mm (long axis size), and the ablation operation lasts for 20 minutes. It should be noted that the above ice ball size is measured in a 37°C gelatin environment. Therefore, when the ablation needle is connected in the connecting pipeline, the pressure of the working fluid storage tank is controlled so that the consumption (total amount) of liquid nitrogen meets the requirement of less than 20% (for the minimum diameter of the ablation needle connected in the connecting pipeline).

[0195] Example 3

[0196] The number of ablation needles connected in the connecting pipeline is 2.

[0197] The diameters of the ablation needles are 3mm and 2.6mm. The target pressure of the working fluid storage tank is 650kPa. When the pressure of the working fluid storage tank is less than 600kPa, the controller controls the boost valve to be fully opened and controls the vent valve to be fully closed; when the pressure of the working fluid storage tank is between 600kPa-700kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 700kPa, the controller controls the vent valve to be gradually opened; when the pressure of the working fluid storage tank is less than 620Pa, the controller controls the vent valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 650kPa.

[0198] When this ablation needle is used for ablation, the liquid nitrogen consumption is about 28%, and the ablation operation lasts for 20 minutes.

[0199] The diameters of the ablation needles are 1.7mm and 1.7mm. The target pressure of the working fluid storage tank is 850kPa. When the pressure of the working fluid storage tank is less than 800kPa, the controller controls the boost valve to be fully opened and controls the vent valve to be fully closed; when the pressure of the working fluid storage tank is between 800kPa-900kPa, the controller controls the boost valve to be gradually closed; when the pressure of the working fluid storage tank is greater than 800kPa, the controller controls the vent valve to be gradually opened; when the pressure of the working fluid storage tank is less than 820Pa, the controller controls the vent valve to be fully closed, thereby dynamically adjusting the pressure of the working fluid storage tank to 850kPa.

[0200] When this ablation needle is used for ablation, the liquid nitrogen consumption is about 32%, the ice ball size is about 30mm (short axis 1 size) × 37mm (short axis 2 size) × 46mm (long axis size) (the distance between the two ablation needles is 10mm), and the ablation operation lasts for 20 minutes. It should be noted that the above ice ball size is measured in a 37°C gelatin environment.

[0201] Therefore, when the ablation needle is connected in the connecting pipeline, the consumption (total amount) of liquid nitrogen basically meets the requirement of less than 30% (for the minimum diameter of the ablation needle connected in the connecting pipeline) by controlling the pressure of the working fluid storage tank.

[0202] Although the present invention has been described with reference to preferred embodiments, various modifications may be made thereto and parts thereof may be replaced by equivalents without departing from the scope of the present invention. In particular, the various technical features mentioned in the various embodiments may be combined in any manner as long as there are no structural conflicts. The present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A composite high-low temperature cold and hot ablation system, characterized in that: It includes a working fluid storage tank, a phase separation valve, a connecting pipeline, an ablation needle and a controller, wherein the connecting pipeline is used to connect with the working fluid storage tank, the phase separation valve and the ablation needle, and the controller is connected with the working fluid storage tank, the phase separation valve and the ablation needle respectively; Wherein, the controller is configured to adjust the pressure of the working fluid storage tank according to the number of the ablation needles connected in the connecting pipeline and the diameter of the ablation needles connected in the connecting pipeline; The controller is configured to: when the number of the ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is greater than d 1; or when the number of the ablation needles connected in the connecting pipeline is ≥ 2 and the diameter of the ablation needle is ≥ d 2, the controller controls the boost valve and / or the air release valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 1, among which, d 1< d 2.

2. The combined high-low temperature cold and hot ablation system according to claim 1, characterized in that: The controller is configured to: when the pressure of the working fluid storage tank is less than P 1-Δ P 2, the controller controls the boost valve to be fully opened and controls the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 1-Δ P 2 to P 1+Δ P 2, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 1+Δ P 2, the controller controls the air release valve to open gradually; when the pressure of the working fluid storage tank is less than P 1-Δ P 1, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 1; in, P 1 is the pressure of the working fluid storage tank, Δ P 1. Δ P 2 are the pressure changes of the working fluid storage tank, Δ P 1<Δ P 2.

3. The combined high-low temperature cold and hot ablation system according to claim 1 or 2, characterized in that: The controller is configured to: when the number of the ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is d 2 and d 1, or when the number of the ablation needles connected in the connecting pipeline is ≥ 2 and the diameter of the ablation needle is < d 2, the controller controls the boost valve and / or the air release valve on the working fluid storage tank, thereby adjusting the pressure of the working fluid storage tank to P 2; in, P 1. P 2 are the pressures of the working fluid storage tanks, P 1< P 2.

4. The combined high-low temperature cold and hot ablation system according to claim 3, characterized in that: The controller is configured to: when the pressure of the working fluid storage tank is less than P 2-Δ P 2, the controller controls the boost valve to be fully opened and controls the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 2-Δ P 2 to P 2+Δ P 2, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 2-Δ P 2, the controller controls the air release valve to open gradually; when the pressure of the working fluid storage tank is less than P 2-Δ P 1, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 2; Among them, Δ P 1. Δ P 2 are the pressure changes of the working fluid storage tank, Δ P 1<Δ P 2.

5. The combined high-low temperature cold and hot ablation system according to claim 3, characterized in that: The controller is configured to: when the number of the ablation needles connected in the connecting pipeline is 1 and the diameter of the ablation needle is less than d 2, the controller adjusts the pressure of the working fluid storage tank to P 3; Wherein, when the pressure of the working fluid storage tank is less than P 3-2Δ P 2, control the boost valve to be fully opened and control the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 3-2Δ P 2 to P 3-Δ P 2, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 3-Δ P 2, the controller controls the air release valve to open gradually; when the pressure of the working fluid storage tank is less than P 3-Δ P 3, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 2; in, P 1. P 2. P 3 are the pressures of the working fluid storage tanks, P 1< P 2< P 3; Δ P 1. Δ P 2. Δ P 3 are the pressure changes of the working fluid storage tank, Δ P 1<Δ P 2<Δ P 3.

6. The combined high-low temperature cold and hot ablation system according to claim 2, characterized in that: The controller is configured such that, when the number of the ablation needles connected in the connecting pipeline is 0, the controller controls the boost valve and / or the deflation valve on the working fluid storage tank, thereby increasing the pressure of the working fluid storage tank from P 3 Adjust to P 1-Δ P 2; Wherein, when the pressure of the working fluid storage tank is less than P 1-2Δ P 2, control the boost valve to be fully opened and control the air release valve to be fully closed; when the pressure of the working fluid storage tank is P 1-2Δ P 2 to P 1, the controller controls the boost valve to gradually close; when the pressure of the working fluid storage tank is greater than P 1, the controller controls the air release valve to open gradually; when the pressure of the working fluid storage tank is less than P 1-Δ P 3, the controller controls the air release valve to be completely closed, thereby adjusting the pressure of the working fluid storage tank to P 1-Δ P 2; in, P 2. P 3 are the pressure of the working fluid storage tank, Δ P 3 is the pressure change of the working fluid storage tank, Δ P 1<Δ P 2<Δ P 3< P 1< P 3.

7. The combined high-low temperature cold and hot ablation system according to claim 5, characterized in that: P 1 is 650kPa, P 2 is 850kPa, P 3 is 1000kPa.

8. The combined high-low temperature cold and hot ablation system according to claim 5, characterized in that: Δ P 1 is 5Kpa~30kPa, Δ P 2 is 10Kpa~50kPa, Δ P 3 is 30kPa~80kPa.

9. A control method for a composite high-low temperature cold and hot ablation system, characterized in that: The control method is applied to the composite high-low temperature cold and hot ablation system according to any one of claims 1 to 8, and the control method comprises the following steps: 100: Determine whether the number of ablation needles connected in the connecting pipeline is 0, if yes, execute step 200, if no, execute step 300; 200: Increase the pressure of the working fluid storage tank from P 3 Adjust to P 1-Δ P 2; 300: Determine whether the number of ablation needles connected in the connecting pipeline is 1, if yes, execute step 400, if no, execute step 500; 400: Determine whether the diameter of the ablation needle connected in the connecting pipeline is ≥ d 1. If yes, adjust the pressure of the working fluid storage tank to P 1, if not, proceed to step 401; 401: Determine whether the diameter of the ablation needle connected to the connecting pipeline is within d 2 and d 1, if so, adjust the pressure of the working fluid storage tank to P 2. If not, execute step 402; 402: Determine whether the diameter of the ablation needle connected in the connecting pipeline is less than d 2. If yes, adjust the pressure of the working fluid storage tank to P 3; 500: Determine whether the diameter of the ablation needle connected in the connecting pipeline is ≥ d 2. If yes, adjust the pressure of the working fluid storage tank to P 1, if not, execute step 501; 501: Determine whether the diameter of the ablation needle connected in the connecting pipeline is less than d 2. If yes, adjust the pressure of the working fluid storage tank to P 2; Among them, Δ P 2< P 1< P 2< P 3.

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