A meal replacement composition for regulating blood sugar balance and controlling weight and a preparation method thereof

Abstract

The present invention discloses a meal replacement composition for regulating blood sugar balance and controlling weight and a preparation method thereof, wherein the meal replacement composition is comprehensive in nutrition, can achieve a good satiety effect, effectively delays starch absorption, thereby controlling postprandial blood sugar and controlling weight, and is suitable for general consumers. The composition of the present invention specifically includes the following raw materials by weight, functional grain powder, skim milk powder, inulin, resistant maltodextrin, walnut oligopeptide powder, pea oligopeptide powder, burdock powder, vegetable fat powder and sweetener. The present invention optimizes the method, modifies starch, combines starch with β-glucan, combines the technical means of spray drying, and then inhibits starch absorption, and has a strong sense of fullness after eating. At the same time, β-glucan can accelerate the formation of a mucus layer on the small intestinal wall, slow down the speed of food delivery to the intestine, thereby causing a decrease in food digestibility, and ultimately helps to maintain postprandial blood sugar homeostasis.

Description

Technical Field

[0001] The present invention relates to the technical field of food, and in particular to a meal replacement composition for regulating blood sugar balance and controlling body weight and a preparation method thereof. Background Art

[0002] As living standards improve, people's dietary structure has also changed. Due to the increase in the proportion of high-calorie, high-carb diets, the proportion of people with type 2 diabetes has increased year by year. Scientific research has found that 90% of type 2 diabetes is an insulin-resistant disease, and its main cause is insulin resistance. The cause is that the body will habitually use sugar and carbohydrates as the main source of energy due to constant eating, and the enzymes related to the use and burning of stored fat in the body will decrease, which will increase insulin resistance.

[0003] In order to improve this situation, as nutritional therapy continues to deepen in the clinic, people have found that adjusting the structure and quantity of the diet plays a key role, such as total calorie control, balanced diet, GI value of food, dietary fiber, etc. These nutritional treatments will benefit diabetic patients more, thereby improving the quality of life of patients and saving medical resources. Therefore, the use of diet to regulate blood sugar or to assist in lowering blood sugar through diet has gradually attracted people's attention. The main means is to use calorie-controlled meal replacement products, and reduce the intake of carbohydrates, fats and energy in the diet, increase the proportion of dietary fiber and high-quality protein, which helps to maintain blood sugar balance. It is worth noting that excessive reduction of carbohydrates and excessive increase of dietary fiber will bring adverse consequences. For example, excessive intake of dietary fiber can cause constipation, bloating or diarrhea, and too few carbohydrates can accelerate fat metabolism and produce ketone bodies. The accumulation of a large number of ketone bodies in the body can lead to ketoacidosis, causing symptoms such as nausea and vomiting.

[0004] In recent years, low GI diet has become a hot topic in the study of nutritional prevention and treatment of chronic diseases. This type of food has a long residence time in the gastrointestinal tract, low absorption rate, slow glucose release, and low peak value after glucose enters the blood. It is advocated to choose low GI food, which is conducive to increasing satiety, delaying hunger, and helping to control postprandial blood sugar in diabetic patients. Using natural food raw materials, using natural food rich in functional active ingredients to make meal replacement powder, not only satisfies the appetite of diabetics, but also plays a role in nutritional treatment. However, the types of low GI meal replacement powders in the existing technology on the market are limited, the taste is single, and it cannot meet people's needs. Meal replacement foods suitable for general users to assist in hypoglycemia or suitable for outdoor consumption by diabetics are even rarer. Moreover, these meal replacement products simply emphasize low GI values, and they do not have a unified formula mechanism and a clear weight loss mechanism. Most of them are considered from the extension of satiety to control energy intake, and achieve the effect of weight loss. Therefore, it is a problem to be solved in this field to obtain a meal replacement product with a clear formula mechanism, high satiety effect, and full nutrition. The needs, and good weight loss or weight control effect. Summary of the invention

[0005] The object of the present invention is to provide a meal replacement composition for regulating blood sugar balance and controlling body weight. The meal replacement composition is nutritionally comprehensive, can effectively delay starch absorption, and effectively control postprandial blood sugar and body weight, and is suitable for general consumers.

[0006] The objective of the present invention is achieved through the following technical scheme: a meal replacement composition for regulating blood sugar balance and controlling weight, comprising the following raw materials in parts by weight: functional cereal powder, skim milk powder, inulin, resistant maltodextrin, walnut oligopeptide powder, pea oligopeptide powder, burdock powder, vegetable fat powder and sweetener.

[0007] Preferably, the specific raw materials are 20-30 parts by weight of functional cereal powder, 6-10 parts of skim milk powder, 3-5 parts of inulin, 3-5 parts of resistant maltodextrin, 3-8 parts of walnut oligopeptide powder, 4-8 parts of pea oligopeptide powder, 4-7 parts of burdock powder, 6-10 parts of vegetable fat powder and 1-2 parts of sweetener.

[0008] Preferably, the specific raw materials by weight are 25 parts of functional cereal powder, 6 parts of skim milk powder, 5 parts of inulin, 3 parts of resistant maltodextrin, 4 parts of walnut oligopeptide powder, 6 parts of pea oligopeptide powder, 6 parts of burdock powder, 8 parts of vegetable fat powder and 2 parts of sweetener.

[0009] Preferably, the sweetener is one or more of xylitol, maltitol, fructooligosaccharide, stachyose and isomaltooligosaccharide.

[0010] Preferably, the functional cereal powder is prepared from highland barley and oats.

[0011] Preferably, the weight proportions of highland barley and oats are 10-15 parts of highland barley and 5-10 parts of oats respectively.

[0012] Preferably, the weight proportions of highland barley and oats are 15 parts of highland barley and 10 parts of oats respectively.

[0013] The composition of the present invention can be added with other raw materials and auxiliary materials to be prepared into a meal replacement product, specifically in the form of meal replacement powder, meal replacement milkshake, meal replacement bar, or meal replacement porridge.

[0014] Preferably, the composition of the present invention can be used as a special medical formula food. Preferably, it can be applied to related uses of people with diabetes, obesity, fatty liver, etc. It is easy to digest and absorb, and can be used to correct and improve symptoms such as malnutrition. Preferably, the formula product of the present invention can also be formulated into bread, hard candy, soft candy, beverage, dairy product, biscuit, noodles.

[0015] The present invention also provides a method for preparing functional cereal powder, comprising the following specific steps:

[0016] (1) Take highland barley and oats according to weight, grind them through a 60-80 mesh sieve, soak them in 30-50°C warm water, with a solid-liquid ratio of 1g: (5-10)mL, and grind them in a colloid mill to obtain a slurry;

[0017] (2) Based on the sum of the mass of highland barley and oats mixed, 0.05% cellulase (400 U / mg) and 3% xylanase (6500 U / g) were added to the slurry in a mass ratio, and the mixture was shaken in a water bath at 45-55° C. for 5-8 hours at a shaking speed of 100-200 rpm to obtain an enzyme solution mixture;

[0018] (3) centrifuging the enzyme solution mixture for 10-15 minutes at a centrifugal speed of 2500-3500 rpm to obtain a white precipitate and a supernatant, filtering the white precipitate, washing it with deionized water and anhydrous ethanol for three times, respectively, and drying it to obtain starch powder;

[0019] (4) The supernatant is adjusted to pH 4.5 with food-grade acetic acid or citric acid while stirring to precipitate the protein, centrifuge, and filter to obtain a filtrate;

[0020] (5) The filtrate is ultrafiltered and concentrated using a membrane separator with a molecular weight cutoff of 3000 to obtain a concentrated solution, wherein the reverse osmosis pressure is 1.5-2.0 MPa, and the solution is concentrated to 30-50% of the original solution;

[0021] (6) The concentrated solution is stirred and ethanol with a concentration of more than 95% is added to the solution until the ethanol content reaches 55-60%, a precipitate is precipitated, and the β-glucan precipitate is separated by centrifugation. The β-glucan is washed with an appropriate amount of 75-80% ethanol solution, and freeze-dried to obtain β-glucan powder;

[0022] (7) Take the β-glucan powder, add it to an aqueous solution and stir to dissolve, to obtain a β-glucan aqueous solution, then add starch powder, stir to dissolve for 20-40 min, and then spray dry to obtain functional cereal powder, wherein the β-glucan powder and water are in a ratio of (6-10) g: (4-5) L, the mass ratio of the β-glucan powder to the starch powder is (6-10):100, the inlet temperature of the spray drying is 160-170°C, the spray gas flow rate is 500-600 L / h, the feed rate is 10-20%, and the outlet temperature is 70-80°C.

[0023] Preferably, the drying in step (3) can be performed by airflow drying or freeze drying.

[0024] Additionally, the present invention provides a method for preparing a meal replacement composition for regulating blood sugar balance and controlling weight, comprising the following steps:

[0025] (1) Mixing: Weigh the above raw materials in parts by weight and mix them evenly to obtain a mixed material;

[0026] (2) Grinding: Grinding the mixed material, and passing it through a 60-80 mesh sieve to obtain fine powder;

[0027] (3) Packaging: The fine powder is sterilized and then packaged.

[0028] Beneficial effects of the present invention:

[0029] The present invention provides a meal replacement composition for regulating blood sugar balance and controlling weight, wherein the formula is rich in high dietary fiber and protein, low in fat and carbohydrates, and sweeteners are also added to the formula to enhance the taste, which will not cause blood sugar fluctuations; burdock powder can promote blood circulation, remove gastrointestinal garbage, reduce cholesterol and blood sugar, and the inulin it contains is also suitable for long-term consumption; walnut oligopeptides can improve the digestive system and promote nutrient absorption; pea oligopeptides have a certain auxiliary blood sugar regulation function, and these small molecule peptides can be quickly and actively absorbed by the human body, can promote the growth of probiotics in the intestine, and comprehensively improve the digestive system capacity; the added dietary fiber can intercept digestive enzymes through water absorption and swelling, inhibit and delay the digestion of carbohydrates, prevent the diffusion of glucose, prevent the rapid rise of blood sugar after a meal, and can also reduce the contact of carbohydrates with the intestinal wall in the small intestine, change the sensitivity of peripheral tissues to insulin, produce a sense of fullness, and help users control their diet. Therefore, the meal replacement composition of the present invention is a good choice for controlling weight and assisting in regulating blood sugar.

[0030] The composition of the present invention has reasonable compatibility. On the one hand, it can be eaten as a nutritional meal replacement product, fully meet the dietary nutritional needs of users, and has no side effects when eaten for a long time. On the other hand, the present invention modifies starch so that starch is combined with beta-glucan, thereby inhibiting starch absorption, and having a strong sense of fullness after eating. At the same time, beta-glucan can accelerate the formation of a mucus layer on the small intestinal wall, slow down the speed of food delivery to the intestine, thereby causing a decrease in food digestibility, and ultimately helping to maintain postprandial blood sugar homeostasis. The present invention studies the separation and purification of highland barley and oat starch and beta-glucan at the same time, and under the technical means of spray drying, starch and beta-glucan form an effective complex, so that the composition can delay starch absorption and effectively regulate blood sugar balance. The starch of the present invention adopts a method of combining two enzymes for extraction, which can retain the original structure of starch to the maximum extent. After the method is optimized, the combination effect of starch and beta-glucan is more excellent. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is the starch hydrolysis rate curve of the functional cereal flour prepared by spray drying under different starch extraction methods in Experimental Example 1 of the present invention. DETAILED DESCRIPTION

[0032] The following will be described clearly and completely in conjunction with the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] Example 1

[0034] A meal replacement composition for regulating blood sugar balance and controlling weight, specifically composed of the following raw materials: 25 parts of functional grain powder, 6 parts of skim milk powder, 5 parts of inulin, 3 parts of resistant maltodextrin, 4 parts of walnut oligopeptide powder, 6 parts of pea oligopeptide powder, 6 parts of burdock powder, 8 parts of vegetable fat powder and 2 parts of stachyose;

[0035] The preparation of the meal replacement composition comprises the following steps:

[0036] (1) Take 15 parts of highland barley and 5 parts of oats, grind them through a 60-mesh sieve, soak them in 30°C warm water with a solid-liquid ratio of 1g::6mL for 30 min, and then grind them with a colloid mill to obtain a slurry;

[0037] (2) Based on the sum of the mass of the mixed barley and oats, 0.05% cellulase (400 U / mg) and 3% xylanase (6500 U / g) were added to the slurry in a mass ratio, and the mixture was shaken in a water bath at 50° C. for 5 h at a shaking speed of 200 rpm to obtain an enzyme solution mixture;

[0038] (3) centrifuging the enzyme solution mixture for 15 minutes at a centrifugal speed of 3000 rpm to obtain a white precipitate and a supernatant, filtering the white precipitate, washing it with deionized water and anhydrous ethanol for three times, respectively, and drying it to obtain starch powder;

[0039] (4) The supernatant is adjusted to pH 4.5 with food-grade acetic acid or citric acid while stirring to precipitate the protein, centrifuge, and filter to obtain a filtrate;

[0040] (5) The filtrate is concentrated by ultrafiltration using a membrane separator with a molecular weight cutoff of 3000 to obtain a concentrated solution, wherein the reverse osmosis pressure is 2.0 MPa and the solution is concentrated to 45% of the original solution;

[0041] (6) The concentrated solution is stirred and ethanol with a concentration of 95% or more is added to the solution until the ethanol content reaches 60%, a precipitate is precipitated, and the β-glucan precipitate is separated by centrifugation. The β-glucan is washed with an appropriate amount of 80% ethanol solution, and freeze-dried to obtain β-glucan powder;

[0042] (7) taking the β-glucan powder, adding it to an aqueous solution and stirring to dissolve it to obtain a β-glucan aqueous solution, then adding starch powder, stirring to dissolve for 30 minutes, and then spray drying to obtain functional cereal powder, wherein the β-glucan powder and water are in a ratio of 8g:4.5L, the mass ratio of the β-glucan powder to the starch powder is 8:100, the inlet temperature of the spray drying is 160°C, the spray gas flow rate is 600L / h, the feed rate is 20%, and the outlet temperature is 70°C;

[0043] (8) Weighing the functional grain powder and other raw materials according to weight, and mixing them evenly to obtain a mixed material;

[0044] (9) crushing the mixed material, and passing it through a 60-mesh sieve to obtain fine powder;

[0045] (10) The fine powder is sterilized and then packaged.

[0046] Example 2

[0047] A meal replacement composition for regulating blood sugar balance and controlling weight, specifically composed of the following raw materials: 20 parts of functional grain powder, 6 parts of skim milk powder, 3 parts of inulin, 3 parts of resistant maltodextrin, 3 parts of walnut oligopeptide powder, 4 parts of pea oligopeptide powder, 4 parts of burdock powder, 6 parts of vegetable fat powder and 1 part of oligofructose;

[0048] The preparation of the meal replacement composition comprises the following steps:

[0049] (1) Take 10 parts of highland barley and 5 parts of oats, grind them through a 60-mesh sieve, soak them in 30°C warm water with a solid-liquid ratio of 1g:5mL for 30 minutes, and then grind them with a colloid mill to obtain a slurry;

[0050] (2) Based on the sum of the mass of the mixed barley and oats, 0.05% cellulase (400 U / mg) and 3% xylanase (6500 U / g) were added to the slurry in a mass ratio, and the mixture was shaken in a water bath at 45° C. for 5 h at a shaking speed of 100 rpm to obtain an enzyme solution mixture;

[0051] (3) centrifuging the enzyme solution mixture for 10 minutes at a centrifugal speed of 2500 rpm to obtain a white precipitate and a supernatant, filtering the white precipitate, washing it with deionized water and anhydrous ethanol for three times, respectively, and drying it to obtain starch powder;

[0052] (4) The supernatant is adjusted to pH 4.5 with food-grade acetic acid or citric acid while stirring to precipitate the protein, centrifuge, and filter to obtain a filtrate;

[0053] (5) The filtrate is concentrated by ultrafiltration using a membrane separator with a molecular weight cutoff of 3000 to obtain a concentrated solution, wherein the reverse osmosis pressure is 1.5 MPa and the solution is concentrated to 30% of the original solution;

[0054] (6) The concentrated solution is stirred and ethanol with a concentration of 95% or more is added to the concentrated solution until the ethanol content reaches 55%, a precipitate is precipitated, and the β-glucan precipitate is separated by centrifugation. The β-glucan is washed with an appropriate amount of 75% ethanol solution, and freeze-dried to obtain β-glucan powder;

[0055] (7) taking the β-glucan powder, adding it to an aqueous solution and stirring to dissolve it to obtain a β-glucan aqueous solution, then adding starch powder, stirring to dissolve for 20 minutes, and then spray drying to obtain functional cereal powder, wherein the β-glucan powder and water are in a ratio of 6g:5L, the mass ratio of the β-glucan powder to the starch powder is 6:100, the inlet temperature of the spray drying is 160°C, the spray gas flow rate is 500L / h, the feed rate is 10%, and the outlet temperature is 70°C;

[0056] (8) Weighing the functional grain powder and other raw materials according to weight, and mixing them evenly to obtain a mixed material;

[0057] (9) crushing the mixed material, and passing it through a 60-mesh sieve to obtain fine powder;

[0058] (10) The fine powder is sterilized and then packaged.

[0059] Example 3

[0060] A meal replacement composition for regulating blood sugar balance and controlling weight, specifically composed of the following raw materials: 30 parts of functional grain powder, 10 parts of skim milk powder, 5 parts of inulin, 5 parts of resistant maltodextrin, 8 parts of walnut oligopeptide powder, 8 parts of pea oligopeptide powder, 7 parts of burdock powder, 10 parts of vegetable fat powder and 2 parts of isomaltooligosaccharide;

[0061] The preparation of the meal replacement composition comprises the following steps:

[0062] (1) Take 10 parts of highland barley and 10 parts of oats, grind them through an 80-mesh sieve, soak them in 50°C warm water with a solid-liquid ratio of 1g:10mL for 60min, and then grind them with a colloid mill to obtain a slurry;

[0063] (2) Based on the sum of the mass of highland barley and oats mixed, 0.05% cellulase (400 U / mg) and 3% xylanase (6500 U / g) were added to the slurry in a mass ratio, and the mixture was shaken in a water bath at 55° C. for 8 h at a shaking speed of 200 rpm to obtain an enzyme solution mixture;

[0064] (3) centrifuging the enzyme solution mixture for 15 minutes at a centrifugal speed of 3500 rpm to obtain a white precipitate and a supernatant, filtering the white precipitate, washing it with deionized water and anhydrous ethanol for three times, respectively, and drying it to obtain starch powder;

[0065] (4) The supernatant is adjusted to pH 4.5 with food-grade acetic acid or citric acid while stirring to precipitate the protein, centrifuge, and filter to obtain a filtrate;

[0066] (5) The filtrate is concentrated by ultrafiltration using a membrane separator with a molecular weight cutoff of 3000 to obtain a concentrated solution, wherein the reverse osmosis pressure is 2.0 MPa and the solution is concentrated to 50% of the original solution;

[0067] (6) The concentrated solution is stirred and ethanol with a concentration of 95% or more is added to the solution until the ethanol content reaches 60%, a precipitate is precipitated, and the β-glucan precipitate is separated by centrifugation. The β-glucan is washed with an appropriate amount of 80% ethanol solution, and freeze-dried to obtain β-glucan powder;

[0068] (7) taking the β-glucan powder, adding it to an aqueous solution and stirring to dissolve it to obtain a β-glucan aqueous solution, then adding starch powder, stirring to dissolve for 40 minutes, and then spray drying to obtain functional cereal powder, wherein the β-glucan powder and water are in a ratio of 10 g:4 L, the mass ratio of the β-glucan powder to the starch powder is 10:100, the inlet temperature of the spray drying is 170°C, the spray gas flow rate is 600 L / h, the feed rate is 20%, and the outlet temperature is 80°C;

[0069] (8) Weighing the functional grain powder and other raw materials according to weight, and mixing them evenly to obtain a mixed material;

[0070] (9) crushing the mixed material, and passing it through an 80-mesh sieve to obtain fine powder;

[0071] (10) The fine powder is sterilized and then packaged.

[0072] Example 4

[0073] A meal replacement composition for regulating blood sugar balance and controlling weight, specifically composed of the following raw materials: 25 parts of functional grain powder, 8 parts of skim milk powder, 4 parts of inulin, 4 parts of resistant maltodextrin, 6 parts of walnut oligopeptide powder, 6 parts of pea oligopeptide powder, 5 parts of burdock powder, 8 parts of vegetable fat powder and 1.5 parts of maltitol;

[0074] The preparation of the meal replacement composition comprises the following steps:

[0075] (1) Take 15 parts of highland barley and 5 parts of oats, grind them through a 70-mesh sieve, soak them in 40°C warm water with a solid-liquid ratio of 1g:8mL for 45min, and then grind them with a colloid mill to obtain a slurry;

[0076] (2) Based on the sum of the mass of the mixed barley and oats, 0.05% cellulase (400 U / mg) and 3% xylanase (6500 U / g) were added to the slurry in a mass ratio, and the mixture was shaken in a water bath at 50° C. for 6.5 h at a shaking speed of 150 rpm to obtain an enzyme solution mixture;

[0077] (3) centrifuging the enzyme solution mixture for 15 minutes at a centrifugal speed of 3000 rpm to obtain a white precipitate and a supernatant, filtering the white precipitate, washing it with deionized water and anhydrous ethanol for three times, respectively, and drying it to obtain starch powder;

[0078] (4) The supernatant is adjusted to pH 4.5 with food-grade acetic acid or citric acid while stirring to precipitate the protein, centrifuge, and filter to obtain a filtrate;

[0079] (5) The filtrate is concentrated by ultrafiltration using a membrane separator with a molecular weight cutoff of 3000 to obtain a concentrated solution, wherein the reverse osmosis pressure is 1.8 MPa and the solution is concentrated to 40% of the original solution;

[0080] (6) The concentrated solution is stirred and ethanol with a concentration of 95% or more is added to the solution until the ethanol content reaches 60%, a precipitate is precipitated, and the β-glucan precipitate is separated by centrifugation. The β-glucan is washed with an appropriate amount of 80% ethanol solution, and freeze-dried to obtain β-glucan powder;

[0081] (7) taking the β-glucan powder, adding it to an aqueous solution and stirring to dissolve it to obtain a β-glucan aqueous solution, then adding starch powder, stirring to dissolve it for 30 minutes, and then spray drying to obtain functional cereal powder, wherein the β-glucan powder and water are in a ratio of 8g:4.5L, the mass ratio of the β-glucan powder to the starch powder is 8:100, the inlet temperature of the spray drying is 170°C, the spray gas flow rate is 550 L / h, the feed rate is 15%, and the outlet temperature is 75°C;

[0082] (8) Weighing the functional grain powder and other raw materials according to weight, and mixing them evenly to obtain a mixed material;

[0083] (9) crushing the mixed material, and passing it through a 70-mesh sieve to obtain fine powder;

[0084] (10) The fine powder is sterilized and then packaged.

[0085] Comparative Example 1

[0086] The difference from Example 1 is that the formula of Comparative Example 1 does not contain burdock powder, and the other raw materials are the same as those of Example 1, and the preparation method is also the same as that of Example 1.

[0087] Comparative Example 2

[0088] The difference from Example 1 is that the formula of Comparative Example 1 does not contain walnut oligopeptide powder, and the other raw materials are the same as those of Example 1, and the preparation method is also the same as that of Example 1.

[0089] Comparative Example 3

[0090] The difference from Example 1 is that the formula of Comparative Example 1 does not contain pea oligopeptide powder, and the other raw materials are the same as those in Example 1, and the preparation method is also the same as that in Example 1.

[0091] Comparative Example 4

[0092] The difference from Example 1 is that the formula of Comparative Example 1 does not contain inulin, and the other raw materials are the same as those of Example 1, and the preparation method is also the same as that of Example 1.

[0093] Comparative Example 5

[0094] Different from Example 1, oligofructose is used instead of inulin, and maltitol is used instead of stachyose. The amount of raw materials used is adjusted, specifically "40 parts of functional cereal powder, 3 parts of skim milk powder, 2 parts of oligofructose, 2 parts of resistant maltodextrin, 2 parts of walnut oligopeptide powder, 3 parts of pea oligopeptide powder, 3 parts of burdock powder, 4 parts of vegetable fat powder and 2 parts of maltitol", and the remaining raw materials and preparation method are also the same as in Example 1.

[0095] Experimental Example 1 Optimization experiment of starch extraction method

[0096] Taking the process of extracting the functional cereal powder in Example 1 as a benchmark, different extraction methods were used to replace the original starch extraction method. The other operations and steps were the same as in Example 1. The in vitro starch digestibility of the functional cereal powder obtained by different methods was investigated and compared. The specific method is as follows:

[0097] Example 1 Method 1: (1) Take 15 parts of highland barley and 5 parts of oats, grind them through a 60-mesh sieve, soak them in 30°C warm water, with a solid-liquid ratio of 1g:6mL, for 30 min, and then grind them with a colloid mill to obtain a slurry;

[0098] (2) Based on the sum of the mass of the mixed barley and oats, 0.05% cellulase (400 U / mg) and 3% xylanase (6500 U / g) were added to the slurry in a mass ratio, and the mixture was shaken in a water bath at 50° C. for 5 h at a shaking speed of 200 rpm to obtain an enzyme solution mixture;

[0099] (3) The enzyme solution mixture was centrifuged for 15 min at a centrifugal speed of 3000 rpm to obtain a white precipitate and a supernatant, which was filtered. The white precipitate was washed three times with deionized water and anhydrous ethanol respectively, and then dried to obtain starch powder.

[0100] Example 1 Method 2: (1) Take 15 parts of highland barley and 5 parts of oats, grind them through a 60-mesh sieve, soak them in 30°C warm water, with a solid-liquid ratio of 1g:6mL, for 30min, and grind them with a colloid mill to obtain a slurry;

[0101] (2) ultrasonicating the slurry at 20 kHz and 200 W for 25 minutes, and then placing it in a water bath at 50° C. for 5 hours to obtain a solution;

[0102] (3) The solution was centrifuged for 15 minutes at a centrifugal speed of 3000 rpm to obtain a white precipitate and a supernatant, which were filtered. The white precipitate was washed three times with deionized water and anhydrous ethanol respectively, and then dried to obtain starch powder.

[0103] Example 1 Method 3: (1) Take 15 parts of highland barley and 5 parts of oats, grind them through a 60-mesh sieve, soak them in 0.125M sodium hydroxide solution, soak them at 30°C for 5 hours, wherein the solid-liquid ratio is 1g:6mL based on the sum of the mass of highland barley and oats, and then grind them with a colloid mill to obtain a slurry;

[0104] (2) The slurry was centrifuged for 15 minutes at a centrifugal speed of 3000 rpm to obtain a white precipitate and a supernatant, which were filtered. The white precipitate was washed three times with deionized water and anhydrous ethanol, respectively, and then dried to obtain starch powder.

[0105] 1. Determination of in vitro digestibility

[0106] 500 mg of the functional cereal powder sample prepared according to the above method was dispersed in 15 mL of sodium acetate solution (0.5 mol / L, pH 5.2), and 5 mL of mixed enzyme solution (α-amylase: 2400 U / mL; α-glucosidase: 500 U / mL) was added. The mixed system was incubated at 37 °C, and 0.5 mL of digestion solution was collected at 0, 10, 20, 30, 60, 90, 120 and 180 min, and 4.5 mL of anhydrous ethanol was added to inactivate the enzymes in the reaction system. The mixture of digestion solution and ethanol was centrifuged at 2200 g for 10 min, and the glucose content in the supernatant was determined. The results were repeated 3 times. The contents of rapidly digestible starch (RDS), slowly digestible starch (SDS) and resistant starch (RS) were calculated according to the following formulas (1)-(3):

[0107] Fast digestible starch (%) = [(G 20 -G0)×0.9] / T S ×100% (1)

[0108] Slowly digestible starch (%) = [(G 120 -G 20 )×0.9] / T S ×100% (2)

[0109] Resistant starch (%) = 100-RDS-SDS (3)

[0110] Where: G0, G 20and G 120 are the glucose contents in the supernatant at 0, 20 and 120 min, respectively; 0.9 is the conversion factor; T S is the quality of the sample.

[0111] Figure 1 The starch hydrolysis curve prepared by spray drying under different starch extraction methods. It can be seen from the curve that the starch hydrolysis rate increases with the increase of digestion time and gradually tends to be flat. The starch of all samples is rapidly digested in 0-30 min, and the starch hydrolysis rate increases slowly in the process of 30min-180min. In the same digestion time, compared with method 2 (ultrasonic extraction) and method 3 (alkali extraction), the starch hydrolysis rate of method 1 in Example 1 is reduced, indicating that the dual enzyme extraction method in Example 1 is better in enhancing the anti-digestion ability of starch. The possible reason is that the enzyme extraction is relatively mild, retaining the complete structure of starch, and the β-glucan and starch system are more likely to copolymerize and modify to form a single helix or crystalline complex through non-covalent interactions such as intermolecular forces, hydrogen bonds and van der Waals forces, thereby reducing the sensitivity of starch to enzymes and synergistically improving the anti-enzymatic performance of starch. It can be concluded that the starch extraction method of method 1 in Example 1 is better than method 2 and method 3, which is conducive to enhancing the anti-digestion ability of starch. The slow digestion of starch will reduce the response to postprandial blood sugar fluctuations to a certain extent.

[0112] Experimental Example 2 Optimization of Spray Conditions

[0113] 1. Optimization of inlet air temperature for spray drying

[0114] Taking the inlet air temperature as a variable and keeping the other parameters unchanged from Example 1, the effects of 140°C, 160°C, 170°C, 180°C and 200°C on the contents of rapidly digestible starch, slowly digestible starch and resistant starch were investigated.

[0115] The results are shown in Table 1. When the inlet air temperature of experimental groups 2-3 was 160℃ and 170℃ respectively, the resistant starch content was higher than that of other experimental groups. Similarly, the sum of slowly digestible starch and resistant starch was also relatively better, which means that the digestion resistance of starch in experimental groups 2-3 was better than that of other groups. The possible reason is that the orderliness of starch arrangement is affected by the inlet air temperature, and thus the binding of starch to β-glucan changes.

[0116] Table 1 Test results of spray drying inlet air temperature

[0117] Experimental groups Inlet air temperature RDS(%) SDS (%) RS(%) SDS+RS(%) Experimental Group 1 140℃ 76.16±0.05 13.40±0.08 10.44±0.09 23.84±0.17 Experimental Group 2 160℃ 75.22±0.06 11.45±0.13 13.33±0.08 24.78±0.21 Experimental Group 3 170℃ 74.86±0.18 11.74±0.05 13.40±0.17 25.14±0.22 Experimental Group 4 180℃ 77.62±0.07 11.08±0.20 11.30±0.10 22.38±0.30 Experimental Group 5 200℃ 76.88±0.13 13.61±0.12 9.51±0.18 23.12±0.30

[0118] 2. Optimization of spray gas flow

[0119] Taking the inlet air temperature as a variable and keeping the other parameters the same as in Example 1, the effects of 300 L / h, 400 L / h, 500 L / h, 600 L / h and 700 L / h on the contents of rapidly digestible starch, slowly digestible starch and resistant starch were investigated.

[0120] The results are shown in Table 2. When the spray gas flow rate of experimental groups 3-4 was 500L / h and 600L / h, respectively, the sum of slowly digestible starch and resistant starch was better than that of other experimental groups. Similarly, the resistant starch content was not significantly different from that of other groups, which means that the digestion resistance of starch in experimental groups 3-4 was better than that of other groups. The possible reason is that with the change of atomization gas flow rate, the size of starch-β-glucan composite particles was affected, and the physical and chemical properties also changed accordingly.

[0121] Table 2 Test results of spray gas flow rate

[0122] Experimental groups Spray gas flow RDS(%) SDS (%) RS(%) SDS+RS(%) Experimental Group 1 300 L / h 76.29±0.08 10.59±0.14 13.12±0.07 23.71±0.21 Experimental Group 2 400 L / h 76.58±0.21 10.36±0.06 13.06±0.10 23.42±0.16 Experimental Group 3 500 L / h 74.65±0.08 12.51±0.11 12.84±0.15 25.35±0.26 Experimental Group 4 600 L / h 74.24±0.13 13.16±0.12 12.60±0.18 25.76±0.30 Experimental Group 5 700 L / h 76.15±0.09 13.61±0.16 10.24±0.16 23.85±0.32

[0123] 3. Optimization of spray feed rate

[0124] Taking the feed rate as a variable and keeping the other parameters the same as in Example 1, the effects of 10%, 15%, 20%, 25% and 30% on the contents of fast-digestible starch, slow-digestible starch and resistant starch were investigated.

[0125] The results are shown in Table 3. When the spray feed rates of experimental groups 1-3 were 10%, 15%, and 20%, respectively, the sum of slowly digestible starch and resistant starch was better than that of other experimental groups. Similarly, the resistant starch content was not significantly different from that of other groups, which means that the digestibility of starch in experimental groups 1-3 was better than that of other groups. The possible reason is that the excessively high feed rate affected the moisture content of starch and affected the complexation of starch and β-glucan.

[0126] Table 3 Test results of spray feed rate

[0127] Experimental groups Spray feed rate RDS(%) SDS (%) RS(%) SDS+RS(%) Experimental Group 1 10% 73.33±0.10 13.43±0.11 13.24±0.08 26.67±0.19 Experimental Group 2 15% 71.26±0.14 14.64±0.16 14.10±0.15 28.74±0.31 Experimental Group 3 20% 74.36±0.18 13.29±0.13 12.35±0.17 25.64±0.30 Experimental Group 4 25% 76.17±0.11 12.17±0.15 11.66±0.09 23.83±0.24 Experimental Group 5 30% 79.61±0.17 9.18±0.07 11.21±0.14 20.39±0.21

[0128] Experimental Example 3: Effect of Meal Replacement Powder on Blood Glucose

[0129] Test method: There are 9 groups in total, including Examples 1-4 and Comparative Examples 1-5. 8 healthy adults, 4 men and 4 women, aged 25-35 years old, with a BMI of 28-33.0 kg / ㎡, no history of diabetes (or impaired glucose tolerance), no other metabolic diseases, digestive system diseases, endocrine system diseases and mental illnesses, etc.; no history of allergy and intolerance to the food to be tested, normal oral glucose tolerance test, regular diet, no recent gastrointestinal diseases and taking any medications, and qualified physical examination. The subjects were trained before the test and signed an informed consent form. Stop eating and drinking after 22:00 the night before the experiment, and monitor the fluctuation of blood sugar after meals.

[0130] Set up a control group: Eat white bread as a reference food for breakfast.

[0131] Evaluation index: Compare the consumption and non-consumption of the compositions of the embodiments of the present invention, with time as the horizontal axis and blood glucose value - fasting blood glucose value at each time point as the vertical axis, to prepare a blood glucose response curve, and calculate the area under the curve (IAUC) above the fasting blood glucose level, inhibition rate = (reference food IAUC - embodiment IAUC) / reference food IAUC * 100%.

[0132] The blood sugar test uses a Roche blood sugar meter. The specific steps for measuring fingertip blood sugar are as follows:

[0133] (1) Collect blood from the fingertip, discard the first drop, and measure fasting blood sugar twice at 5-min intervals and record the results;

[0134] (2) Take 50 mL of water;

[0135] (3) 5 minutes later, eat a slice of white bread (calculated as 50 g of carbohydrate intake) and 200 ml of water (complete eating within 5 minutes);

[0136] (4) Collect fingertip blood to test blood sugar and record it (15min, 30min, 45min, 60min, 90min, 120min after meal). The average inhibition rate statistics of each embodiment and comparative example are shown in Table 4.

[0137] Table 4 Statistical results of average inhibition rate

[0138] Group Average inhibition rate / % Example 1 63.2±1.2 Example 2 57.8±1.8 Example 3 59.3±1.6 Example 4 60.3±1.4 Comparative Example 1 46.7±1.6 Comparative Example 2 48.0±1.7 Comparative Example 3 45.4±1.8 Comparative Example 4 50.1±1.3 Comparative Example 5 47.4±1.2

[0139] According to the above test results, it can be seen that the composition provided by the present invention has a better auxiliary hypoglycemic effect of controlling blood sugar rise than the comparative example, so it can be reflected that the lack of some raw materials or the adjustment of the weight of the raw materials weakens the effect of the composition, and it can be seen that there is a synergistic effect between the raw materials. At the same time, by observing the blood sugar values ​​corresponding to different time points, it can be seen that the present invention can delay the time when blood sugar reaches a peak to a certain extent, and has a certain effect of controlling sugar and regulating blood sugar balance.

[0140] Experimental Example 4: Effect of Meal Replacement Powder on Body Weight

[0141] To further investigate the effect of the composition on weight control, the test method of this experimental example is as follows: 80 volunteers were selected, half male and half female, aged 23-50 years old, without other metabolic diseases, digestive system diseases, endocrine system diseases and mental diseases, etc.; no history of allergy and intolerance to the food to be tested, no recent gastrointestinal diseases and no taking of any drugs. The subjects were trained before the test and signed an informed consent.

[0142] 80 volunteers were divided into two groups, A and B, a total of 8 groups, of which 4 groups A (A1, A2, A3 and A4) were BMI 26.0-35.0kg / m2, belonging to mild obesity or obesity; the other 4 groups B (B1, B2, B3 and B4) were BMI 18.5-24kg / m2, belonging to normal weight. Each group had 5 males and 5 females.

[0143] Diet method: The volunteers in group A and group B used the meal replacement powder prepared by the method described in Examples 1-4 to replace breakfast and dinner, respectively, with each meal not exceeding 100 g. The experimental period was 8 weeks, and the weight of the subjects in each group was checked and recorded, and the statistical results are shown in Table 5.

[0144] Table 5 Statistics on the effects of meal replacement powder on body weight

[0145] Group Lose 10% or more of your body weight Lose less than 10% of your body weight and lose more than 1kg Body weight remains basically unchanged (±1kg) Weight gain of more than 1kg Example 1-A1 4 6 0 0 Example 2-A2 3 7 0 0 Example 3-A3 3 6 1 0 Example 4-A4 4 5 1 0 Example 1-B1 0 2 8 0 Example 2-B2 0 1 8 1 Example 3-B3 0 1 7 2 Example 4-B4 0 2 6 2

[0146] The results showed that for the mildly obese or obese volunteers in Group A, most of the volunteers lost weight after 8 weeks of consumption, indicating that 30%-40% of the volunteers had returned to normal weight, and more than 50% of the volunteers had lost weight. For the normal weight volunteers in Group B, after taking the meal replacement powder, 60-80% of the volunteers were able to maintain their weight well, and some had a slight decrease or increase in weight.

[0147] The above description is only a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements without departing from the principle of the present invention. These improvements should also be regarded as within the protection scope of the present invention.

Claims

1. A meal replacement composition for regulating blood sugar balance and controlling weight, characterized in that: The invention is composed of the following raw materials in parts by weight: 20-30 parts of functional grain powder, 6-10 parts of skim milk powder, 3-5 parts of inulin, 3-5 parts of resistant maltodextrin, 3-8 parts of walnut oligopeptide powder, 4-8 parts of pea oligopeptide powder, 4-7 parts of burdock powder, 6-10 parts of vegetable fat powder and 1-2 parts of sweetener, wherein the functional grain powder is prepared from highland barley and oats; The preparation of the functional cereal powder comprises the following steps: (1) Take 10-15 parts of highland barley and 5-10 parts of oats by weight, grind them through a 60-80 mesh sieve, soak them in 30-50°C warm water, with a solid-liquid ratio of 1g: (5-10)mL, and grind them in a colloid mill to obtain a slurry; (2) Based on the sum of the mass of highland barley and oats, 0.05% cellulase and 3% xylanase were added to the slurry in a mass ratio, and the mixture was shaken in a water bath at 45-55° C. for 5-8 hours at a shaking speed of 100-200 rpm to obtain an enzyme solution mixture, wherein the enzymatic activity of the cellulase was 400 U / mg and the enzymatic activity of the xylanase was 6500 U / g; (3) centrifuging the enzyme solution mixture for 10-15 minutes at a centrifugal speed of 2500-3500 rpm to obtain a white precipitate and a supernatant, filtering the white precipitate, washing it with deionized water and anhydrous ethanol for three times, respectively, and drying it to obtain starch powder; (4) The supernatant is adjusted to pH 4.5 with food-grade acetic acid or citric acid while stirring to precipitate the protein, centrifuge, and filter to obtain a filtrate; (5) The filtrate is ultrafiltered and concentrated using a membrane separator with a molecular weight cutoff of 3000 to obtain a concentrated solution, wherein the reverse osmosis pressure is 1.5-2.0 MPa, and the concentrated solution is concentrated to 30-50% of the original solution; (6) The concentrated solution is stirred and ethanol with a concentration of more than 95% is added to the solution until the ethanol content reaches 55-60%, a precipitate is precipitated, and the β-glucan precipitate is separated by centrifugation. The β-glucan is washed with an appropriate amount of 75-80% ethanol solution, and freeze-dried to obtain β-glucan powder; (7) taking the β-glucan powder, adding it to an aqueous solution and stirring to dissolve it, thereby obtaining a β-glucan aqueous solution, then adding the starch powder obtained in step (3), stirring to dissolve it for 20-40 min, and then spray drying it to obtain a functional cereal powder; The β-glucan powder and water are in a ratio of (6-10) g: (4-5) L, the mass ratio of the β-glucan powder to the starch powder is (6-10): 100, the inlet air temperature of the spray drying is 160-170°C, the spray gas flow rate is 500-600 L / h, the feed rate is 10-20%, and the outlet air temperature is 70-80°C.

2. A meal replacement composition for regulating blood sugar balance and controlling weight according to claim 1, characterized in that: The specific raw materials by weight are 25 parts of functional cereal powder, 6 parts of skim milk powder, 5 parts of inulin, 3 parts of resistant maltodextrin, 4 parts of walnut oligopeptide powder, 6 parts of pea oligopeptide powder, 6 parts of burdock powder, 8 parts of vegetable fat powder and 2 parts of sweetener.

3. A meal replacement composition for regulating blood sugar balance and controlling weight according to claim 1, characterized in that: The sweetener is one or more of xylitol, maltitol, oligofructose, stachyose and isomaltooligosaccharide.

4. A meal replacement composition for regulating blood sugar balance and controlling weight according to claim 1, characterized in that: The weight proportions of highland barley and oats are 15 parts of highland barley and 5 parts of oats.

5. A method for preparing a meal replacement composition for regulating blood sugar balance and controlling body weight according to any one of claims 1 to 4, characterized in that: The following steps are involved: (1) Take 10-15 parts of highland barley and 5-10 parts of oats by weight, grind them through a 60-80 mesh sieve, soak them in 30-50°C warm water, with a solid-liquid ratio of 1g: (5-10)mL, and grind them in a colloid mill to obtain a slurry; (2) Based on the sum of the mass of highland barley and oats, add 0.05% cellulase and 3% xylanase, shaking in a water bath at 45-55°C for 5-8h, with a shaking speed of 100-200 rpm, to obtain an enzyme solution mixture, wherein the enzyme activity of the cellulase is 400 U / mg, and the enzyme activity of the xylanase is 6500 U / g; (3) centrifuging the enzyme solution mixture for 10-15 minutes at a centrifugal speed of 2500-3500 rpm to obtain a white precipitate and a supernatant, filtering the white precipitate, washing it with deionized water and anhydrous ethanol for three times, respectively, and drying it to obtain starch powder; (4) The supernatant is adjusted to pH 4.5 with food-grade acetic acid or citric acid while stirring to precipitate the protein, centrifuge, and filter to obtain a filtrate; (5) The filtrate is ultrafiltered and concentrated using a membrane separator with a molecular weight cutoff of 3000 to obtain a concentrated solution, wherein the reverse osmosis pressure is 1.5-2.0 MPa, and the concentrated solution is concentrated to 30-50% of the original solution; (6) The concentrated solution is stirred and ethanol with a concentration of more than 95% is added to the solution until the ethanol content reaches 55-60%, a precipitate is precipitated, and the β-glucan precipitate is separated by centrifugation. The β-glucan is washed with an appropriate amount of 75-80% ethanol solution, and freeze-dried to obtain β-glucan powder; (7) taking the β-glucan powder, adding it to an aqueous solution and stirring to dissolve it, thereby obtaining a β-glucan aqueous solution, then adding the starch powder obtained in step (3), stirring to dissolve it for 20-40 min, and then spray drying it to obtain a functional cereal powder; (8) Mixing: Weighing the above raw materials in parts by weight and mixing them evenly to obtain a mixed material; (9) Grinding: Grinding the mixed material, and passing it through a 60-80 mesh sieve to obtain fine powder; (10) Packaging: The fine powder is sterilized and then packaged.

6. The method for preparing a meal replacement composition for regulating blood sugar balance and controlling weight according to claim 5, characterized in that: The drying in step (3) can be either airflow drying or freeze drying.

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