Method and device for determining a plate internal fixation system for bone defect reconstruction

Abstract

The present invention discloses a method and device for determining a steel plate internal fixation system for bone defect reconstruction, and relates to the field of medical technology. The method comprises: obtaining a bone defect reconstruction model of a target object, and determining an initial steel plate internal fixation system corresponding to the bone defect reconstruction model; generating a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system, and performing finite element analysis based on the finite element analysis model to obtain an analysis result; comparing the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, and determining a target steel plate internal fixation system corresponding to the target object based on the comparison result and the initial steel plate internal fixation system. The present invention solves the technical problem in the prior art that the standard steel plate internal fixation system has poor fixation stability, which affects the healing of bone defects.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a method and device for determining a steel plate internal fixation system for bone defect reconstruction. Background Art

[0002] Large bone defects in the limbs are often caused by tumors, infections, severe trauma, etc. For large complex bone defects in the limbs of adults and joint-preserving reconstruction after partial long bone (diaphysis and / or metaphysis) resection of malignant tumors in the limbs of children, biological reconstruction (reconstruction of the defect with bone transplant materials) is generally the main method. After biological reconstruction, internal fixation with a steel plate is required.

[0003] At present, the steel plates used in the existing technology for internal fixation are mainly designed for traumatic fractures. Since the periosteum of large bone defects is often severely damaged, the treatment of bone tumors often requires extensive stripping of soft tissues and muscle resection, which leads to severe damage to blood supply. Therefore, very strong internal fixation is required during treatment, and radiotherapy and other treatments may be required in the future. Simple fractures often have better blood supply, and fixation only plays an auxiliary role. After the bone heals, it no longer relies on the steel plate, etc., while the tumor may rely on the support and fixation effect of the steel plate for several years after surgery. Therefore, the existing traumatic steel plate internal fixation system used in bone defect reconstruction has the following problems:

[0004] (1) Poor adhesion for complex defects or pediatric cases: The standardized plate shape and the bone contact side cannot achieve satisfactory adhesion with the bone surface of the fixation site. The lack of adhesion of the plate will lead to unreliable fixation of large complex defects, stress concentration of the fixation screws, and increased stimulation to the surrounding tissues after surgery. In the long term, it may lead to fatigue failure of internal fixation, fracture of screws or plates, and effusion around the plate, affecting postoperative function;

[0005] (2) Difficulty in intraoperative nail placement: Due to the differences in defect size, defect range, and bone graft conditions among individual patients, conventional plate surgery cannot satisfactorily place nails according to the specific conditions of each patient. This may result in inaccurate nail placement in the tumor area, difficulty in placing nails, and inability to fix nails in adjacent joints or under articular cartilage, which may affect the initial postoperative stability and lead to bone nonunion. In some pediatric patients, fixation cannot be performed without avoiding the epiphyseal plate, which may affect bone development in the future.

[0006] (3) Too long implantation time: During surgery, the fixation of large complex bone defects after tumor resection or caused by various reasons often requires multiple steel plates, which require the inner and outer steel plates to be implanted and fixed in sequence. After the first side is implanted, the second side of the steel plate is often difficult to implant into the expected anatomical position because the bone end has been fixed, and a satisfactory reduction effect cannot be achieved, affecting subsequent bone healing. In addition, the fixation process requires repeated bending of standard steel plates to meet the requirements, which greatly prolongs the operation time.

[0007] (4) Completely different application concepts: The concept of reduction and fixation during bone defect reconstruction is completely different from that of fractures in trauma surgery. The reduction design of existing steel plates is not suitable for reduction and fixation during bone defect reconstruction. Inappropriate reduction will lead to delayed bone healing and increase the possibility of internal fixation failure in the long term.

[0008] To address the above-mentioned problems, no effective solution has been proposed yet. Summary of the invention

[0009] The embodiment of the present invention provides a method and device for determining a steel plate internal fixation system for bone defect reconstruction, so as to at least solve the technical problem that the standard steel plate internal fixation system in the prior art has poor fixation stability, which affects the healing of bone defects.

[0010] According to one aspect of an embodiment of the present invention, a method for determining a steel plate internal fixation system for bone defect reconstruction is provided, comprising: obtaining a bone defect reconstruction model of a target object, and determining an initial steel plate internal fixation system corresponding to the bone defect reconstruction model, wherein the bone defect reconstruction model is obtained after simulating osteotomy of a target bone on a three-dimensional bone model of a target bone of the target object, and the initial steel plate internal fixation system at least includes an initial steel plate model and an initial screw arrangement model; generating a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system, and performing finite element analysis based on the finite element analysis model to obtain an analysis result, wherein the analysis result is used to characterize state information of the finite element analysis model under stress; comparing the analysis result with a standard stress model in a steel plate stress model library to obtain a comparison result, and determining a target steel plate internal fixation system corresponding to the target object based on the comparison result and the initial steel plate internal fixation system, wherein the standard stress model is used to characterize stress distribution and deformation characteristics of the steel plate under different stress conditions.

[0011] Furthermore, determining an initial steel plate internal fixation system corresponding to the bone defect reconstruction model includes: determining screw arrangement information based on the bone defect reconstruction model; and determining an initial steel plate model and an initial screw arrangement model from multiple steel plate templates in a steel plate template database based on the screw arrangement information.

[0012] Furthermore, a finite element analysis model is generated based on the bone defect reconstruction model and the initial steel plate internal fixation system, including: aligning the initial steel plate model with the bone defect reconstruction model, and adjusting the steel plate size and shape of the initial steel plate model to adapt to the bone defect area in the bone defect reconstruction model; adjusting the position and layout of the screw holes of the initial screw arrangement model based on the adjusted steel plate model to obtain an adjusted screw arrangement model; generating an adjusted steel plate internal fixation system based on the adjusted steel plate model and the adjusted screw arrangement model; and assembling the adjusted steel plate internal fixation system on the bone defect reconstruction model to obtain a finite element analysis model.

[0013] Further, a finite element analysis is performed based on the finite element analysis model to obtain an analysis result, including: meshing the finite element analysis model to obtain a meshed model, wherein the meshed model is composed of multiple mesh elements; obtaining the HU value of each bone area in the meshed model, and calculating the bone density value of each bone area based on the HU value of each bone area, and calculating the elastic modulus of each bone area based on the bone density value of each bone area; determining the HU value and elastic modulus corresponding to each mesh element based on the HU value of each bone area and the elastic modulus of each bone area, and assigning each mesh element based on the HU value and elastic modulus corresponding to each mesh element to obtain a meshed model containing material properties; performing a finite element force analysis on the meshed model containing material properties based on the first constraint condition and the second constraint condition to obtain an analysis result, wherein the first constraint condition is used to simulate the vertical pressure on the meshed model containing material properties, and the second constraint condition is used to simulate the front-to-back pressure on the meshed model containing material properties.

[0014] Furthermore, the analysis results include at least a maximum stress value that the finite element analysis model can withstand, wherein the analysis results are compared with a standard stress model in a steel plate stress model library to obtain a comparison result, including: comparing the maximum stress value with a stress value threshold in the standard stress model to obtain a comparison result.

[0015] Furthermore, a target steel plate internal fixation system corresponding to the target object is determined based on the comparison result and the initial steel plate internal fixation system, including: if the comparison result is that the maximum stress value is greater than the stress value threshold, the initial steel plate internal fixation system is adjusted to obtain a first steel plate internal fixation system; repeatedly generating a finite element analysis model based on the bone defect reconstruction model and the first steel plate internal fixation system, performing finite element analysis based on the finite element analysis model to obtain an analysis result, and comparing the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, until the comparison result is that the maximum stress value is less than or equal to the stress value threshold, and the target steel plate internal fixation system is obtained.

[0016] Furthermore, before obtaining the bone defect reconstruction model of the target object, the method also includes: performing geometric modeling based on the image data of the target bone to obtain a three-dimensional bone model of the target bone; identifying a bone defect area on the three-dimensional bone model of the target bone, and determining an osteotomy line and an osteotomy area based on the bone defect area; performing simulated osteotomy on the three-dimensional bone model of the target bone based on the osteotomy line and the osteotomy area to obtain a bone defect reconstruction model.

[0017] According to another aspect of an embodiment of the present invention, there is also provided a device for determining a steel plate internal fixation system for bone defect reconstruction, comprising: an acquisition unit, for acquiring a bone defect reconstruction model of a target object, and determining an initial steel plate internal fixation system corresponding to the bone defect reconstruction model, wherein the bone defect reconstruction model is obtained by simulating osteotomy of a target bone on a three-dimensional bone model of a target bone of the target object, and the initial steel plate internal fixation system comprises at least an initial steel plate model and an initial screw arrangement model; a processing unit, for generating a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system, and performing finite element analysis based on the finite element analysis model to obtain an analysis result, wherein the analysis result is used to characterize state information of the finite element analysis model under stress; a determination unit, for comparing the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, and determining a target steel plate internal fixation system corresponding to the target object based on the comparison result and the initial steel plate internal fixation system, wherein the standard force model is used to characterize the stress distribution and deformation characteristics of the steel plate under different force conditions.

[0018] According to another aspect of an embodiment of the present invention, a computer program product is provided, including a computer program, which implements the above-mentioned method for determining a steel plate internal fixation system for bone defect reconstruction when executed by a processor.

[0019] According to another aspect of an embodiment of the present invention, a computer-readable storage medium is provided, in which a computer program is stored, wherein the computer program is configured to execute the above-mentioned method for determining a steel plate internal fixation system for bone defect reconstruction when running.

[0020] According to another aspect of an embodiment of the present invention, there is also provided an electronic device, which includes one or more processors; a memory for storing one or more programs, which, when the one or more programs are executed by the one or more processors, enables the one or more processors to run the programs, wherein the program is configured to execute the above-mentioned method for determining the steel plate internal fixation system for bone defect reconstruction when running.

[0021] In an embodiment of the present invention, a bone defect reconstruction model of a target object is obtained, and an initial steel plate internal fixation system corresponding to the bone defect reconstruction model is determined, wherein the bone defect reconstruction model is obtained after simulating osteotomy of a target bone on a three-dimensional bone model of a target bone of the target object, and the initial steel plate internal fixation system includes at least an initial steel plate model and an initial screw arrangement model; a finite element analysis model is generated according to the bone defect reconstruction model and the initial steel plate internal fixation system, and a finite element analysis is performed based on the finite element analysis model to obtain an analysis result, wherein the analysis result is used to characterize state information of the finite element analysis model under stress; the analysis result is compared with a standard stress model in a steel plate stress model library to obtain a comparison result, and based on the comparison result and the initial steel plate internal fixation system The target plate internal fixation system corresponding to the target object is determined, wherein the standard force model is used to characterize the stress distribution and deformation characteristics of the plate under different force conditions. By obtaining the bone defect reconstruction model of the target object, the internal fixation system can be customized according to the bone anatomical characteristics and defect conditions of each patient to ensure that the plate and screws are well attached to the bone, reduce stimulation and pressure, and improve the stability of fixation. By performing finite element analysis based on the finite element analysis model, the risks of complications such as internal fixation failure, plate fracture, and fluid accumulation around the plate can be effectively reduced. By determining the target plate internal fixation system corresponding to the target object based on the comparison results and the initial plate internal fixation system, the use of standardized plates is avoided, the need for intraoperative plate cutting and adjustment is reduced, and the operation time is reduced.

[0022] It can be seen that through the technical solution of the present invention, the purpose of effective reconstruction and fixation after bone defect is achieved, thereby realizing the technical effect of improving the fixation stability of the internal fixation system, and further solving the technical problem that the fixation stability of the standard steel plate internal fixation system in the prior art is poor, which affects the healing of bone defects. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this application. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0024] Figure 1 is a flow chart of an optional method for determining a steel plate internal fixation system for bone defect reconstruction according to an embodiment of the present invention;

[0025] Figure 2 is a schematic diagram of a workflow of a manufacturing system of an optional steel plate internal fixation system according to an embodiment of the present invention;

[0026] Figure 3 is a schematic diagram of an optional steel plate model according to an embodiment of the present invention;

[0027] Figure 4 is a schematic diagram of the module composition of an optional steel plate internal fixation system according to an embodiment of the present invention;

[0028] Figure 5 is a schematic diagram of optional high-density bone data according to an embodiment of the present invention;

[0029] Figure 6 is a schematic diagram of optional high-density bone data and low-density bone data according to an embodiment of the present invention;

[0030] Figure 7 is a schematic diagram of an optional tumor erosion region according to an embodiment of the present invention;

[0031] Figure 8 is a schematic diagram of an optional lateral proximal joint plate module according to an embodiment of the present invention;

[0032] Fig. 9 is a schematic diagram of an optional medial proximal articular plate module according to an embodiment of the present invention;

[0033] Fig.10 is a schematic diagram of an optional internal fixation assembly according to an embodiment of the present invention;

[0034] Fig.11 is a schematic diagram of an optional screw arrangement according to an embodiment of the present invention;

[0035] Fig.12 is a schematic diagram of an optional force model according to an embodiment of the present invention;

[0036] Fig.13 is a schematic diagram of an optional determination device of a steel plate internal fixation system for bone defect reconstruction according to an embodiment of the present invention;

[0037] Fig.14 is a schematic diagram of an optional electronic device according to an embodiment of the present invention. DETAILED DESCRIPTION

[0038] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0039] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0040] It should be noted that the relevant information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data for display, data for analysis, etc.) involved in the present invention are all information and data authorized by the user or fully authorized by all parties. For example, an interface is set up between this system and the relevant user or organization. Before obtaining relevant information, it is necessary to send an acquisition request to the aforementioned user or organization through the interface, and obtain relevant information after receiving the consent information fed back by the aforementioned user or organization.

[0041] Example 1

[0042] According to an embodiment of the present invention, an embodiment of a method for determining a steel plate internal fixation system for bone defect reconstruction is provided. It should be noted that the steps shown in the flowchart of the accompanying drawings can be executed in a computer system such as a set of computer executable instructions, and although a logical order is shown in the flowchart, in some cases, the steps shown or described can be executed in an order different from that shown here.

[0043] Figure 1 is a flow chart of a method for determining an optional steel plate internal fixation system for bone defect reconstruction according to an embodiment of the present invention, such as Figure 1 As shown, the method comprises the following steps:

[0044] Step S101, obtaining a bone defect reconstruction model of the target object, and determining an initial steel plate internal fixation system corresponding to the bone defect reconstruction model, wherein the bone defect reconstruction model is obtained by simulating osteotomy of the target bone on a three-dimensional bone model of the target bone of the target object, and the initial steel plate internal fixation system includes at least an initial steel plate model and an initial screw arrangement model.

[0045] In the above steps, the bone defect reconstruction model of the target object can be obtained through application systems, processors, electronic devices and other devices. Optionally, the bone defect reconstruction model of the target object can be obtained through a determination system of a steel plate internal fixation system for bone defect reconstruction, and an initial steel plate internal fixation system corresponding to the bone defect reconstruction model can be determined.

[0046] In an optional embodiment, before obtaining the bone defect reconstruction model of the target object, geometric modeling is performed based on the image data of the target bone to obtain a three-dimensional bone model of the target bone; the bone defect area is identified on the three-dimensional bone model of the target bone, and the osteotomy line and osteotomy area are determined based on the bone defect area; and simulated osteotomy is performed on the three-dimensional bone model of the target bone based on the osteotomy line and osteotomy area to obtain a bone defect reconstruction model.

[0047] Optionally, taking the case where the target object is a child patient, a skeletal anatomical model is first established, that is, geometric modeling is performed based on the imaging data (such as CT scan data, MRI data) of the target bone of the child patient (taking the tibia as an example) to obtain a three-dimensional skeletal model of the tibia, and then defect simulation reconstruction is performed, that is, the range and shape of the bone defect area are identified on the three-dimensional skeletal model of the tibia, the osteotomy line and osteotomy area are determined according to the range and shape of the bone defect area, and then simulated osteotomy is performed on the three-dimensional skeletal model of the tibia according to the osteotomy line and osteotomy area to obtain a bone defect reconstruction model.

[0048] In an optional embodiment, determining an initial steel plate internal fixation system corresponding to a bone defect reconstruction model includes: determining screw arrangement information based on the bone defect reconstruction model; and determining an initial steel plate model and an initial screw arrangement model from a plurality of steel plate templates in a steel plate template database based on the screw arrangement information.

[0049] Optionally, after the bone defect reconstruction model is constructed, an internal fixation system is designed to determine an initial steel plate internal fixation system corresponding to the bone defect reconstruction model. First, screw arrangement information is determined based on the bone defect reconstruction model, and then an initial steel plate model and an initial screw arrangement model can be determined from multiple steel plate templates in a steel plate template database based on the screw arrangement information.

[0050] For example, according to the shape and position of the bone defect reconstruction model, the steel plate model and screw arrangement that can match the bone defect reconstruction model are retrieved from the steel plate template database, and according to the internal fixation matching rules, the personalized steel plates and internal fixation screws of the initial size and shape are attached to the appropriate positions of the bone defect reconstruction model to determine the initial steel plate model and the initial screw arrangement model.

[0051] Step S102, generating a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system, and performing finite element analysis based on the finite element analysis model to obtain analysis results, wherein the analysis results are used to characterize state information of the finite element analysis model under stress.

[0052] Optionally, a finite element analysis model can be generated based on the bone defect reconstruction model and the initial steel plate internal fixation system, and then a finite element analysis is performed based on the finite element analysis model to obtain an analysis result.

[0053] In an optional embodiment, a finite element analysis model is generated based on the bone defect reconstruction model and the initial steel plate internal fixation system, including: aligning the initial steel plate model with the bone defect reconstruction model, and adjusting the steel plate size and shape of the initial steel plate model to adapt to the bone defect area in the bone defect reconstruction model; adjusting the position and layout of the screw holes of the initial screw arrangement model based on the adjusted steel plate model to obtain an adjusted screw arrangement model; generating an adjusted steel plate internal fixation system based on the adjusted steel plate model and the adjusted screw arrangement model; and assembling the adjusted steel plate internal fixation system on the bone defect reconstruction model to obtain a finite element analysis model.

[0054] Optionally, the initial steel plate model and the bone defect reconstruction model are aligned (such as by translation, rotation, scaling, etc.), and the steel plate size and shape of the initial steel plate model are adjusted to adapt to the bone defect area in the bone defect reconstruction model, and then refined. The positions and layouts of the screw holes of the initial screw arrangement model are adjusted according to the adjusted steel plate model to obtain an adjusted screw arrangement model, and an adjusted steel plate internal fixation system is generated according to the adjusted steel plate model and the adjusted screw arrangement model, and then the adjusted steel plate internal fixation system is assembled on the bone defect reconstruction model to obtain a finite element analysis model.

[0055] In an optional embodiment, a finite element analysis is performed based on a finite element analysis model to obtain an analysis result, including: meshing the finite element analysis model to obtain a meshed model, wherein the meshed model is composed of a plurality of mesh elements; obtaining the HU value of each bone region in the meshed model, and calculating the bone density value of each bone region based on the HU value of each bone region, and calculating the elastic modulus of each bone region based on the bone density value of each bone region; determining the HU value and elastic modulus corresponding to each mesh element based on the HU value of each bone region and the elastic modulus of each bone region, and assigning a value to each mesh element based on the HU value and elastic modulus corresponding to each mesh element to obtain a meshed model including material properties; performing a finite element force analysis on the meshed model including material properties based on a first constraint condition and a second constraint condition to obtain an analysis result, wherein the first constraint condition is used to simulate the vertical pressure on the meshed model including material properties, and the second constraint condition is used to simulate the front-to-back pressure on the meshed model including material properties.

[0056] Optionally, the finite element analysis model is first meshed to obtain a meshed model composed of multiple mesh elements, and then the HU value of each bone area in the meshed model is obtained, and the bone density value of each bone area is calculated based on the HU value of each bone area, and the elastic modulus of each bone area is calculated based on the bone density value of each bone area, and then the HU value and elastic modulus corresponding to each mesh element can be determined based on the HU value of each bone area and the elastic modulus of each bone area, and each mesh element is assigned a value based on the HU value and elastic modulus corresponding to each mesh element to obtain a meshed model containing material properties, and then a finite element force analysis is performed on the meshed model containing material properties based on the first constraint condition and the second constraint condition to obtain an analysis result, wherein the analysis result can be stress distribution data and displacement data of each mesh element.

[0057] Step S103, comparing the analysis result with the standard force model in the steel plate force model library to obtain a comparison result, and determining the target steel plate internal fixation system corresponding to the target object based on the comparison result and the initial steel plate internal fixation system, wherein the standard force model is used to characterize the stress distribution and deformation characteristics of the steel plate under different force conditions.

[0058] Optionally, after obtaining the finite element analysis results, the analysis results are compared with the standard stress model in the steel plate stress model library to obtain a comparison result, and a target steel plate internal fixation system corresponding to the target object is determined based on the comparison result and the initial steel plate internal fixation system.

[0059] For example, the steel plate stress model library is accessed, and the finite element analysis results are compared with the standard stress model in the steel plate stress model library. For example, the maximum stress value that the finite element analysis model can withstand is compared with the stress value threshold in the standard stress model to obtain a comparison result. According to the comparison result, the stability and mechanical properties of the internal fixation system on the bone after defect reconstruction are evaluated. For example, if the comparison result is that the maximum stress value is greater than the stress value threshold, the initial steel plate internal fixation system is adjusted until the comparison result is that the maximum stress value is less than or equal to the stress value threshold, and the target steel plate internal fixation system is obtained.

[0060] Based on the scheme defined by the above steps S101 to S103, it can be known that in an embodiment of the present invention, a bone defect reconstruction model of the target object is obtained, and an initial steel plate internal fixation system corresponding to the bone defect reconstruction model is determined, wherein the bone defect reconstruction model is obtained after simulating osteotomy of the target bone on the three-dimensional bone model of the target bone of the target object, and the initial steel plate internal fixation system at least includes an initial steel plate model and an initial screw arrangement model; a finite element analysis model is generated based on the bone defect reconstruction model and the initial steel plate internal fixation system, and a finite element analysis is performed based on the finite element analysis model to obtain an analysis result, wherein the analysis result is used to characterize the state information of the finite element analysis model under stress; the analysis result is compared with the standard force model in the steel plate force model library to obtain a comparison result, and based on the The target plate internal fixation system corresponding to the target object is determined according to the comparison results and the initial plate internal fixation system, wherein the standard force model is used to characterize the stress distribution and deformation characteristics of the plate under different force conditions. By obtaining the bone defect reconstruction model of the target object, the internal fixation system can be customized according to the bone anatomical characteristics and defect conditions of each patient to ensure that the plate and screws are well attached to the bone, reduce stimulation and pressure, and improve the stability of fixation. By performing finite element analysis based on the finite element analysis model, the risks of complications such as internal fixation failure, plate fracture, and fluid accumulation around the plate can be effectively reduced. By determining the target plate internal fixation system corresponding to the target object based on the comparison results and the initial plate internal fixation system, the use of standardized plates is avoided, the need for intraoperative plate cutting and adjustment is reduced, and the operation time is reduced.

[0061] It can be seen that through the technical solution of the present invention, the purpose of effective reconstruction and fixation after bone defect is achieved, thereby realizing the technical effect of improving the fixation stability of the internal fixation system, and further solving the technical problem that the fixation stability of the standard steel plate internal fixation system in the prior art is poor, which affects the healing of bone defects.

[0062] In an optional embodiment, the analysis results include at least the maximum stress value that the finite element analysis model can withstand, wherein the analysis results are compared with the standard stress model in the steel plate stress model library to obtain a comparison result, including: comparing the maximum stress value with the stress value threshold in the standard stress model to obtain a comparison result.

[0063] Optionally, by comparing the maximum stress value with the stress value threshold in the standard force model, it can be determined whether the currently designed initial steel plate internal fixation system meets the use requirements. For example, when the maximum stress value is greater than the stress value threshold, it is considered that the currently designed initial steel plate internal fixation system cannot meet the use requirements; when the maximum stress value is less than or equal to the stress value threshold, it is considered that the currently designed initial steel plate internal fixation system can meet the use requirements.

[0064] In an optional embodiment, a target steel plate internal fixation system corresponding to the target object is determined based on the comparison result and the initial steel plate internal fixation system, including: if the comparison result is that the maximum stress value is greater than the stress value threshold, the initial steel plate internal fixation system is adjusted to obtain a first steel plate internal fixation system; repeatedly generating a finite element analysis model based on the bone defect reconstruction model and the first steel plate internal fixation system, performing finite element analysis based on the finite element analysis model to obtain an analysis result, and comparing the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, until the comparison result is that the maximum stress value is less than or equal to the stress value threshold, and the target steel plate internal fixation system is obtained.

[0065] Optionally, if the comparison result is that the maximum stress value is greater than the stress value threshold, it is considered that the currently designed initial steel plate internal fixation system cannot meet the use requirements, and the initial steel plate internal fixation system is adjusted to obtain a first steel plate internal fixation system, and then the steps of generating a finite element analysis model based on the bone defect reconstruction model and the first steel plate internal fixation system are repeated, and a finite element analysis is performed based on the finite element analysis model to obtain an analysis result, and the analysis result is compared with a standard force model in a steel plate force model library to obtain a comparison result, until the comparison result is that the maximum stress value is less than or equal to the stress value threshold, and a target steel plate internal fixation system is obtained.

[0066] In an optional embodiment, it is possible to use Figure 2 The schematic diagram shown in the figure realizes the design of the internal fixation system of the steel plate. Figure 2 is a schematic diagram of a workflow of a manufacturing system of an optional steel plate internal fixation system according to an embodiment of the present invention. Optionally, the manufacturing system includes an input device, a modeling device, a design device, an analysis device, a processing device, etc. Figure 2As shown, the input device scans the patient's limb bone and cartilage data and inputs them into the modeling device. The modeling device establishes a bone anatomical model and a defect reconstruction model according to the patient's physiological and pathological parameters and treatment plan. After the bone anatomical model and the defect reconstruction model are input into the design device, the design device accesses the steel plate design template database, retrieves the steel plate model and screw arrangement that can be adapted to the defect reconstruction model, and then, according to the internal fixation matching rules, attaches the personalized steel plate and internal fixation screws of the initial size and shape to the appropriate position of the defect reconstruction model, and then combines the internal fixation system with the defect reconstruction model, and performs the design according to the patient's injury. The force model establishes a finite element analysis model, and then outputs the finite element analysis model to the analysis equipment, performs finite element analysis on the model, and the analysis equipment accesses the typical steel plate force model library, compares the finite element analysis results with the standard force model in the steel plate force model library, and determines whether the failure mode is acceptable under the limit of internal fixation. If it is not acceptable, the product design size, shape, and fixing screw arrangement and other information need to be changed according to the force and failure conditions. If it is acceptable, the design report is output, and the doctor confirms the design of the final internal fixation system, outputs the processing instructions to the processing equipment, and completes the final processing of the steel plate internal fixation system. After the implantation of the customized internal fixation system is completed, the postoperative statistical database can be accessed to perform post-implantation imaging analysis, analyze the patient's recovery and implant deformation, and then summarize the postoperative imaging analysis results, and iteratively update the design template database and the force model library.

[0067] Optionally, the input device can be a patient image data scanning device that can convert the patient's bone data and pathological data into a data sequence that can be recognized by a computer. The modeling device can be a computer device, including hardware and software such as a processor, a memory, an operating system, and a computer program for modeling. Through a dedicated computer program, the patient's bone image data sequence can be converted into three-dimensional model data. The design device can be a computer device, including hardware and software such as a processor, a memory, an operating system, and a computer program for design. After inputting the three-dimensional model data, the three-dimensional model can be attached to the internal fixation system, and the design parameters of the internal fixation system can be adjusted, and a finite element analysis model and a processed three-dimensional model can be output. The analysis device can be a computer device, including hardware and software such as a processor, a memory, an operating system, and a computer program for analysis. The finite element analysis model and the patient's age, height, weight and other information can be input, and the force analysis model of the patient after internal fixation can be obtained through analysis and calculation. The processing device can be a CNC processing device, which can process the final internal fixation product according to the processed three-dimensional model.

[0068] Optionally, the bone anatomical model building process includes the following steps:

[0069] DICOM data acquisition: Acquire the patient's DICOM data set from medical imaging equipment (such as CT scan, MRI). DICOM data contains the patient's tomographic image information.

[0070] DICOM data preprocessing: DICOM data is preprocessed, including noise removal, image calibration, and slice reconstruction. These preprocessing steps ensure that high-quality image data is obtained.

[0071] 3D reconstruction: Use 3D reconstruction algorithms to stack DICOM slices to generate a 3D model of the patient's bones. Commonly used algorithms include voxel reconstruction, surface reconstruction, etc. These algorithms can convert slice images into continuous 3D bone surfaces or voxel representations.

[0072] Bone segmentation: Perform bone segmentation in the 3D model to separate the bones that need to be used from other bones.

[0073] 3D model repair and post-processing: Perform repair and post-processing operations on the bone model, including filling holes, smoothing surfaces, removing abnormal structures, etc. These steps help generate a complete and accurate bone model.

[0074] Optionally, establishing a defect reconstruction model involves modeling and designing a patient-specific defect area based on the patient's skeletal anatomical model, and mainly includes the following steps:

[0075] Obtaining a skeletal anatomical model: A skeletal anatomical model is established based on the patient's DICOM data, and the above-mentioned DICOM data processing and three-dimensional reconstruction methods can be used.

[0076] Defect area delineation: For example, based on the doctor's instructions and clinical images, the scope and shape of the defect area are determined.

[0077] Defect reconstruction design: Use computer-aided design software or three-dimensional modeling software to create a defect reconstruction model in the bone anatomical model, including creating corresponding geometric shapes (such as autologous bone, allogeneic bone, etc.) in the defect area to fill the defect and connect it with the surrounding normal bone tissue.

[0078] The HU value of each bone area (such as cancellous bone, cortical bone and cartilage) is converted into a bone density value to calculate the bone density of each bone area (used to calculate the elastic modulus). For example, the HU value is converted to bone mineral density (BMD) in mg / cm³ using the following conversion formula:

[0079]

[0080] in, It is a constant parameter in the linear relationship fitted by experiment, and its specific value may vary according to different studies.

[0081] Optionally, the design device retrieves the steel plate design template and refines the steel plate model according to the following steps:

[0082] Data input: Import the bone anatomical model and defect reconstruction model into the design equipment to ensure the accuracy and completeness of the data.

[0083] Steel plate design template database access: The design equipment accesses the steel plate design template database, which stores the design templates and related parameters of various steel plates. These design templates generally include the shape, size, hole layout and other geometric features of the steel plate.

[0084] Defect matching and adaptation: The design equipment searches for a suitable steel plate model in the steel plate design template database based on the shape and position of the defect reconstruction model. Figure 3 is a schematic diagram of an optional steel plate model according to an embodiment of the present invention, such as Figure 3 As shown, it includes an inner steel plate and an outer steel plate. Optionally, the steel plate internal fixation system has multiple modules. Figure 4 Schematic diagram of the module composition of an optional plate internal fixation system according to an embodiment of the present invention, such as Figure 4 As shown, it includes the near-articular plate module, the bone defect segment plate module and the backbone plate module. Each module has a database set according to experience, which contains the internal fixation type, attachment position, internal fixation size, number of screw holes, etc. used by the design module. Each module is adjusted according to the internal fixation requirements of the module. The design device selects the plate design template that best matches the defect reconstruction model to ensure the fit and effective fixation of the plate with the bone anatomical model and the defect reconstruction model.

[0085] Optionally, different factors need to be considered when selecting each module. For example, the near-articular plate module needs to consider the most effective fixation within a limited longitudinal space, and avoid the direction of the screw passing through the articular surface or epiphyseal line; the bone defect segment plate module needs to consider whether its size parameters can achieve effective fixation, and also needs to avoid the direction of the screw passing through the articular surface or epiphyseal line; the backbone plate module needs to consider whether the size of the internal fixation can achieve the optimization requirements of the size under the premise of effective fixation. After selecting the internal fixation type and parameters of each module, the data of each module can be integrated.

[0086] Plate model refinement: After selecting the appropriate plate design template, the design equipment will generate a refined plate model, including aligning the plate model with the bone anatomy model and defect reconstruction model, adjusting the plate size and shape to fit the defect area, and determining the location and layout of the screw holes.

[0087] Parameter adjustment and optimization: The design equipment can also allow users to adjust and optimize parameters to meet specific medical needs and patient conditions, and realize customized design of steel plates, including adjusting the length, width, thickness of the steel plate, adjusting the number and position of screw holes, etc.

[0088] Output results: The design equipment can generate the final steel plate design results, including steel plate model files, screw arrangement diagrams and related design parameters.

[0089] Optionally, the finite element analysis model is output to an analysis device, and the finite element analysis of the model mainly includes the following steps:

[0090] Import model: Import finite element analysis model files into the analysis device. For example, load the model file and perform geometric correction and verification to ensure the accuracy and integrity of the model in the analysis device.

[0091] Material properties and boundary condition settings: Define material properties and boundary conditions in the analysis device to be consistent with the established finite element model, including defining the material properties of each component, constraints and loading conditions of nodes or surfaces, etc.

[0092] Mesh import: If meshing and discretization were performed when the finite element model was established, the exported mesh data can be directly imported into the analysis device. Otherwise, meshing needs to be performed in the analysis device to ensure the consistency of the mesh when the model was established.

[0093] Mesh quality check and repair: Perform quality checks on imported meshes to ensure mesh accuracy and quality. Perform necessary repairs and improvements as needed to improve the accuracy and reliability of finite element analysis.

[0094] Material model and element type selection: Select the appropriate material model and element type in the analysis device according to the analysis requirements and material properties. For example, you can select according to the patient's bone characteristics and the material properties of the defect reconstruction model. Generally, the default data are the elastic modulus and Poisson's ratio of the bones in each part, and these two values ​​can also be converted by the bone density value. The conversion relationship between bone density value, elastic modulus and Poisson's ratio is usually based on experimental data and empirical formulas. Different types of bone tissue (such as cortical bone and cancellous bone) have different empirical formulas.

[0095] Constraints and loads: Set constraints and loads for nodes or surfaces in the analysis device. Apply appropriate boundary constraints and force conditions according to actual conditions to simulate the force conditions of patients in specific situations.

[0096] Model solution: Use the finite element analysis solver in the analysis equipment to solve the model. According to the set boundary conditions and loading conditions, perform numerical calculations to obtain the stress, strain, displacement and other results of the model under load.

[0097] Result analysis and optimization: Analyze and interpret the finite element analysis results to evaluate the stability and mechanical properties of the internal fixation system on the bone after defect reconstruction. According to the analysis results, make necessary optimization designs, such as adjusting the size, position, shape, etc. of the internal fixation system.

[0098] Result output: Export the results of finite element analysis into appropriate file formats, such as graphical results, report files, etc., to facilitate further result presentation, verification and documentation.

[0099] Optionally, comparing the finite element analysis results with the standard stress model in the steel plate stress model library mainly includes the following steps:

[0100] Preparation of steel plate stress model library: Establish a steel plate stress model library, which contains various standard stress models. These standard stress models can be obtained through theoretical calculations, experimental tests or empirical summaries, and represent the stress distribution and deformation characteristics of steel plates under different stress conditions.

[0101] Comparison and evaluation: Compare the finite element analysis results with the standard stress model in the steel plate stress model library. Compare the stress distribution, strain distribution and deformation of the steel plate in different areas. Based on the comparison results, evaluate the stability and mechanical properties of the internal fixation system on the bone after defect reconstruction.

[0102] Optionally, after comparison, determine whether the failure mode is acceptable under the limit condition of internal fixation. If it is unacceptable, the product design needs to be changed according to the stress condition and failure condition, which mainly includes the following steps:

[0103] Product design changes: According to the results of the failure mode assessment, product design changes are made, including adjustments to the size, shape, material selection of the steel plate, length and diameter of the screws, etc. The purpose of the design change is to improve the stability and durability of the internal fixation system under extreme conditions to ensure that it can meet the requirements of safety and functional recovery.

[0104] Re-finite element analysis: Based on the changes in product design, re-conduct finite element analysis to evaluate the stress conditions of the modified internal fixation system under extreme conditions. Ensure that the modified design can effectively improve the stability and durability of the internal fixation system.

[0105] Evaluation and verification: Based on the results of the re-finite element analysis, evaluate and verify the effect of the product design changes. Ensure that the changed design can meet the expected safety and functional recovery requirements.

[0106] Iteration: Based on the results of evaluation and verification, further product design changes and finite element analysis are performed as needed. Through iterative cycles, the design of the internal fixation system is continuously optimized and improved to achieve optimal stability and durability.

[0107] Optionally, outputting a processing instruction to a processing device and completing the final processing of the steel plate internal fixation system mainly includes the following steps:

[0108] Preparation of processing instructions: According to the final confirmed design plan and the parameters of the internal fixation system, formulate corresponding processing instructions, including the geometric dimensions of the steel plate and screws, hole position information, processing technology requirements, etc.

[0109] Processing equipment setup: Prepare and set up the processing equipment to ensure that the equipment is in normal working condition, including steps such as machine tool adjustment, fixture installation and calibration.

[0110] Processing operation: Perform specific processing operations according to processing instructions. For example, operators perform cutting, drilling, milling and other processing procedures of steel plates and screws on processing equipment according to instructions to complete the processing and production of internal fixation systems.

[0111] Optionally, after the implantation is completed, the implant effect needs to be evaluated and compared with literature records or empirical data. The evaluation items are as follows: proximal fusion time, distal fusion time, and deformation of the internal fixation system. Optionally, it is iterated according to the regular statistics of the case, and the steel plate design template database and the typical force database are adjusted. For example, the fusion time is related to the elastic modulus of the nearby steel plate and the number of internal fixation screws. The deformation of the internal fixation is also related to the size parameters of the internal fixation and the typical load-bearing acceptance value. If the internal fixation fails, the typical load-bearing acceptance value needs to be adjusted. The ultimate goal of iterative adjustment is to achieve fusion in the shortest time while ensuring the effectiveness of the internal fixation.

[0112] In an optional embodiment, taking the reconstruction after tibial defect resection as an example, geometric modeling is first performed based on the CT scan data and MRI data of the patient's bones. The bone data (HU values) of different grayscales of the patient can be reversely obtained accurately through the CT scan data. By adjusting the different grayscales, the boundaries of the bone data of different densities of the patient can be accurately obtained through the MRI data. Figure 5 is a schematic diagram of optional high-density bone data according to an embodiment of the present invention, Figure 6 is a schematic diagram of optional high-density bone data and low-density bone data according to an embodiment of the present invention. Figure 5 , Figure 6As shown, the real patient bone data can be obtained by automatically overlapping and fitting the high-density bone data and low-density bone data of the same part of the same patient.

[0113] Optionally, the extent of tumor erosion can be identified based on MRI data. Figure 7 is a schematic diagram of an optional tumor erosion region according to an embodiment of the present invention, such as Figure 7 As shown, the osteotomy area can be automatically identified according to the tumor erosion area. The identification rule is that the tumor erosion range must be covered, and an osteotomy plan must be made, and the osteotomy line must be perpendicular to the patient's cross section.

[0114] Optionally, after the above-mentioned high-density bone data and low-density bone data, tumor erosion area and osteotomy line are imported into the modeling software in combination, reverse engineering technology is used to filter, interpolate, generate entities and other operations on the scanned two-dimensional cross-sectional images to establish a three-dimensional solid model, so as to obtain the geometric model of the bone anatomical model and the defect reconstruction model.

[0115] Optionally, the plate design template database contains different design templates corresponding to multiple modules. Taking the tibial proximal joint plate module as an example, Figure 8 is a schematic diagram of an optional lateral proximal joint plate module according to an embodiment of the present invention, Fig. 9 is a schematic diagram of an optional medial proximal joint plate module according to an embodiment of the present invention, such as Figure 8 , Fig. 9 As shown, there are 3 design templates for the lateral proximal articular plate module and the medial proximal articular plate module.

[0116] Optionally, the internal fixation matching rules of the medial and lateral tibial proximal articular plate modules are as follows: the directions of the medial and lateral screw holes must not interfere with each other, in which case the more bicortical screws that can be implanted in the medial and lateral sides, the better; the direction of the screw must not pass through the epiphysis; the position and direction of the screw must not pass through the osteotomy surface.

[0117] Optionally, the design dimensions of the steel plate are as shown in Table 1. Depending on the weight of the patient, the size also has different requirements. Among them, the specification ≥50KG is a steel plate designed with reference to adults.

[0118] Table 1

[0119]

[0120] Fig.10 is a schematic diagram of an optional internal fixation assembly according to an embodiment of the present invention, Fig.11 is a schematic diagram of an optional screw arrangement according to an embodiment of the present invention, Fig.12 is a schematic diagram of an optional force model according to an embodiment of the present invention, such as Fig.10 , Fig.11 As shown, after the model is assembled, a finite element analysis model can be established for the assembled model according to the patient's force model, for example, Fig.12 The force model shown simulates the vertical pressure on the tibia (F1) and the front-to-back pressure (F2).

[0121] Optionally, it is assumed that all materials are isotropic materials, and the physical parameters of the isotropic materials include two of the shear modulus, the elastic modulus and the Poisson's ratio. Among them, another physical parameter can be solved according to two of the shear modulus, the elastic modulus and the Poisson's ratio.

[0122] Optionally, in the parameters set for simulation, the elastic modulus and Poisson's ratio can be converted by the bone density determined when the bone model is established, and the conversion formula is: elastic modulus E = aBMDb, Poisson's ratio v = cBMDd. Among them, a, b, c, and d are different reference values. For children, different reference values ​​for cancellous bone, cortical bone, and cartilage need to be set based on experience.

[0123] Optionally, by simulating and analyzing the force model under preset boundary conditions and loads, the force conditions of the patient's bones under the motion conditions corresponding to the preset loads can be simulated, and the maximum stress of the original model under the preset boundary conditions and loads can be solved. Optionally, by simulating the force conditions of the proximal joint end of the tibia of adult patients using existing mature designs and the maximum stress of internal fixation, the corresponding typical steel plate force model library data is obtained as shown in Table 2. The finite element analysis results of this particular patient using this solution are shown in Table 3. According to Tables 2 and 3, the maximum stress in this case is less than the maximum stress requirement in the standard library, which shows that the design can meet the requirements of use.

[0124] Table 2

[0125]

[0126] Table 3

[0127]

[0128] Optionally, if the finite element analysis results do not meet the use requirements, it is necessary to change the size of the product, for example, increase the thickness or width of the product, and perform finite element analysis again on the changed results. Optionally, the bone anatomical model diagram, defect reconstruction model diagram, design parameters of the steel plate and screws, finite element analysis results, failure analysis results, and instructions for product design changes are submitted for review. If the review meets the requirements, it will enter the processing stage. The steel plate model is output as a model that can be recognized by the processing equipment, and the software is programmed to identify all surfaces that need to be processed, and the processing program is input into the processing equipment, and the processing equipment completes the final processing.

[0129] In the embodiments of the present invention, the joint structure and limb growth potential can be preserved through personalized design, which is beneficial to the recovery of postoperative function and growth and development. For cases of malignant tumors, limb preservation and precise limb restoration can be performed, which helps patients better adapt to normal life. The steel plate internal fixation system designed according to the patient's skeletal structure and defect condition can be better integrated into the skeleton. When designing the steel plate internal fixation system, the design parameters are adjusted through computer simulation, which reduces the trial and error and adjustment time during the operation and improves the efficiency of the operation. The personalized designed steel plate internal fixation system can better adapt to the patient's skeletal structure and help accelerate bone healing and recovery of the surgical site. The finite element analysis model can provide detailed stress conditions to help doctors better understand the performance of the internal fixation system under different loads, so as to make more accurate surgical decisions.

[0130] It can be seen that through the technical solution of the present invention, the purpose of effective reconstruction and fixation after bone defect is achieved, thereby realizing the technical effect of improving the fixation stability of the internal fixation system, and further solving the technical problem that the fixation stability of the standard steel plate internal fixation system in the prior art is poor, which affects the healing of bone defects.

[0131] Example 2

[0132] According to an embodiment of the present invention, an embodiment of a device for determining a steel plate internal fixation system for bone defect reconstruction is provided, wherein: Fig.13 is a schematic diagram of a determination device of an optional steel plate internal fixation system for bone defect reconstruction according to an embodiment of the present invention, such as Fig.13 As shown, the device includes: an acquisition unit 1301, which is used to acquire a bone defect reconstruction model of a target object, and determine an initial steel plate internal fixation system corresponding to the bone defect reconstruction model, wherein the bone defect reconstruction model is obtained by simulating osteotomy of the target bone on a three-dimensional bone model of the target bone of the target object, and the initial steel plate internal fixation system at least includes an initial steel plate model and an initial screw arrangement model; a processing unit 1302, which is used to generate a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system, and perform finite element analysis based on the finite element analysis model to obtain an analysis result, wherein the analysis result is used to characterize state information of the finite element analysis model under stress; a determination unit 1303, which is used to compare the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, and determine a target steel plate internal fixation system corresponding to the target object based on the comparison result and the initial steel plate internal fixation system, wherein the standard force model is used to characterize the stress distribution and deformation characteristics of the steel plate under different force conditions.

[0133] It should be noted that the above-mentioned acquisition unit 1301, processing unit 1302 and determination unit 1303 correspond to steps S101 to S103 in the above-mentioned embodiment, and the examples and application scenarios implemented by the three units and the corresponding steps are the same, but are not limited to the contents disclosed in the above-mentioned embodiment 1.

[0134] Optionally, the acquisition unit includes: a first determination subunit, used to determine the screw arrangement information based on the bone defect reconstruction model; and a second determination subunit, used to determine the initial steel plate model and the initial screw arrangement model from multiple steel plate templates in the steel plate template database based on the screw arrangement information.

[0135] Optionally, the processing unit includes: a first processing subunit, used to align the initial steel plate model and the bone defect reconstruction model, and adjust the steel plate size and shape of the initial steel plate model to adapt to the bone defect area in the bone defect reconstruction model; a second processing subunit, used to adjust the position and layout of the screw holes of the initial screw arrangement model according to the adjusted steel plate model to obtain an adjusted screw arrangement model; a third processing subunit, used to generate an adjusted steel plate internal fixation system based on the adjusted steel plate model and the adjusted screw arrangement model; a fourth processing subunit, used to assemble the adjusted steel plate internal fixation system on the bone defect reconstruction model to obtain a finite element analysis model.

[0136] Optionally, the processing unit also includes: a fifth processing subunit, which is used to mesh the finite element analysis model to obtain a mesh model, wherein the mesh model is composed of multiple mesh elements; a calculation subunit, which is used to obtain the HU value of each bone area in the mesh model, and calculate the bone density value of each bone area based on the HU value of each bone area, and calculate the elastic modulus of each bone area based on the bone density value of each bone area; a sixth processing subunit, which is used to determine the HU value and elastic modulus corresponding to each mesh element based on the HU value of each bone area and the elastic modulus of each bone area, and assign each mesh element according to the HU value and elastic modulus corresponding to each mesh element to obtain a mesh model containing material properties; a seventh processing subunit, which is used to perform finite element force analysis on the mesh model containing material properties based on the first constraint condition and the second constraint condition to obtain an analysis result, wherein the first constraint condition is used to simulate the vertical pressure on the mesh model containing material properties, and the second constraint condition is used to simulate the front-to-back pressure on the mesh model containing material properties.

[0137] Optionally, the analysis result includes at least a maximum stress value that the finite element analysis model can withstand, wherein the determination unit includes: a comparison subunit, used to compare the maximum stress value with a stress value threshold in a standard force model to obtain a comparison result.

[0138] Optionally, the determination unit also includes: an eighth processing sub-unit, which is used to adjust the initial steel plate internal fixation system to obtain a first steel plate internal fixation system if the comparison result is that the maximum stress value is greater than the stress value threshold; a ninth processing sub-unit, which is used to repeatedly execute the steps of generating a finite element analysis model based on the bone defect reconstruction model and the first steel plate internal fixation system, performing finite element analysis based on the finite element analysis model to obtain an analysis result, and comparing the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, until the comparison result is that the maximum stress value is less than or equal to the stress value threshold, and a target steel plate internal fixation system is obtained.

[0139] Optionally, the determination device of the steel plate internal fixation system for bone defect reconstruction also includes: a first preprocessing unit, used to perform geometric modeling based on the image data of the target bone to obtain a three-dimensional bone model of the target bone before acquiring the bone defect reconstruction model of the target object; a second preprocessing unit, used to identify the bone defect area on the three-dimensional bone model of the target bone, and determine the osteotomy line and osteotomy area based on the bone defect area; a third preprocessing unit, used to simulate osteotomy on the three-dimensional bone model of the target bone based on the osteotomy line and osteotomy area to obtain a bone defect reconstruction model.

[0140] Example 3

[0141] According to another aspect of an embodiment of the present invention, a computer program product is provided, including a computer program, which implements the above-mentioned method for determining a steel plate internal fixation system for bone defect reconstruction when executed by a processor.

[0142] Example 4

[0143] According to another aspect of an embodiment of the present invention, a computer-readable storage medium is provided, in which a computer program is stored, wherein the computer program is configured to execute the above-mentioned method for determining a steel plate internal fixation system for bone defect reconstruction when running.

[0144] Example 5

[0145] According to another aspect of an embodiment of the present invention, there is also provided an electronic device, wherein: Fig.14 is a schematic diagram of an optional electronic device according to an embodiment of the present invention, such as Fig.14As shown, the electronic device includes one or more processors; a memory for storing one or more programs, which, when the one or more programs are executed by the one or more processors, enables the one or more processors to run the programs, wherein the programs are configured to execute the above-mentioned method for determining the plate internal fixation system for bone defect reconstruction when running. When the processor executes the program, the following steps are implemented: obtaining a bone defect reconstruction model of the target object, and determining an initial steel plate internal fixation system corresponding to the bone defect reconstruction model, wherein the bone defect reconstruction model is obtained after simulating osteotomy of the target bone on the three-dimensional bone model of the target bone of the target object, and the initial steel plate internal fixation system at least includes an initial steel plate model and an initial screw arrangement model; generating a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system, and performing finite element analysis based on the finite element analysis model to obtain an analysis result, wherein the analysis result is used to characterize state information of the finite element analysis model under stress; comparing the analysis result with a standard stress model in a steel plate stress model library to obtain a comparison result, and determining a target steel plate internal fixation system corresponding to the target object based on the comparison result and the initial steel plate internal fixation system, wherein the standard stress model is used to characterize stress distribution and deformation characteristics of the steel plate under different stress conditions.

[0146] Optionally, when the processor executes the program, the following steps are also implemented: determining screw arrangement information based on the bone defect reconstruction model; and determining an initial steel plate model and an initial screw arrangement model from multiple steel plate templates in a steel plate template database based on the screw arrangement information.

[0147] Optionally, the processor also implements the following steps when executing the program: aligning the initial steel plate model and the bone defect reconstruction model, and adjusting the steel plate size and shape of the initial steel plate model to adapt to the bone defect area in the bone defect reconstruction model; adjusting the position and layout of the screw holes of the initial screw arrangement model according to the adjusted steel plate model to obtain an adjusted screw arrangement model; generating an adjusted steel plate internal fixation system according to the adjusted steel plate model and the adjusted screw arrangement model; and assembling the adjusted steel plate internal fixation system on the bone defect reconstruction model to obtain a finite element analysis model.

[0148] Optionally, when the processor executes the program, the following steps are also implemented: meshing the finite element analysis model to obtain a meshed model, wherein the meshed model is composed of multiple mesh elements; obtaining the HU value of each bone area in the meshed model, and calculating the bone density value of each bone area based on the HU value of each bone area, and calculating the elastic modulus of each bone area based on the bone density value of each bone area; determining the HU value and elastic modulus corresponding to each mesh element based on the HU value of each bone area and the elastic modulus of each bone area, and assigning each mesh element based on the HU value and elastic modulus corresponding to each mesh element to obtain a meshed model containing material properties; performing finite element force analysis on the meshed model containing material properties based on the first constraint condition and the second constraint condition to obtain an analysis result, wherein the first constraint condition is used to simulate the vertical pressure on the meshed model containing material properties, and the second constraint condition is used to simulate the front-to-back pressure on the meshed model containing material properties.

[0149] Optionally, when executing the program, the processor further implements the following steps: comparing the maximum stress value with a stress value threshold in a standard stress model to obtain a comparison result.

[0150] Optionally, the processor also implements the following steps when executing the program: if the comparison result is that the maximum stress value is greater than the stress value threshold, the initial steel plate internal fixation system is adjusted to obtain a first steel plate internal fixation system; repeatedly generate a finite element analysis model based on the bone defect reconstruction model and the first steel plate internal fixation system, and perform finite element analysis based on the finite element analysis model to obtain an analysis result, and compare the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, until the comparison result is that the maximum stress value is less than or equal to the stress value threshold, and a target steel plate internal fixation system is obtained.

[0151] Optionally, the processor also implements the following steps when executing the program: before obtaining the bone defect reconstruction model of the target object, geometric modeling is performed based on the image data of the target bone to obtain a three-dimensional bone model of the target bone; the bone defect area is identified on the three-dimensional bone model of the target bone, and the osteotomy line and osteotomy area are determined based on the bone defect area; simulated osteotomy is performed on the three-dimensional bone model of the target bone based on the osteotomy line and osteotomy area to obtain a bone defect reconstruction model.

[0152] The devices in this article can be servers, PCs, PADs, mobile phones, etc.

[0153] The serial numbers of the above embodiments of the present invention are only for description and do not represent the advantages or disadvantages of the embodiments.

[0154] In the above embodiments of the present invention, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0155] In the several embodiments provided in this application, it should be understood that the disclosed technical content can be implemented in other ways. Among them, the device embodiments described above are only schematic. For example, the division of the units can be a logical function division. There may be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, indirect coupling or communication connection of units or modules, which can be electrical or other forms.

[0156] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple units. Some or all of the units may be selected according to actual needs to achieve the purpose of the present embodiment.

[0157] In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of software functional units.

[0158] If the integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present invention, in essence, or the part that contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product. The computer software product is stored in a storage medium, including several instructions for a computer device (which can be a personal computer, server or network device, etc.) to perform all or part of the steps of the method described in each embodiment of the present invention. The aforementioned storage medium includes: U disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), mobile hard disk, disk or optical disk, etc. Various media that can store program codes.

[0159] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A method for determining a steel plate internal fixation system for bone defect reconstruction, characterized in that: include: Acquire a bone defect reconstruction model of a target object, and determine an initial steel plate internal fixation system corresponding to the bone defect reconstruction model, wherein the bone defect reconstruction model is obtained by simulating osteotomy of the target bone on a three-dimensional bone model of a target bone of the target object, and the initial steel plate internal fixation system includes at least an initial steel plate model and an initial screw arrangement model; Generate a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system, and perform finite element analysis based on the finite element analysis model to obtain analysis results, wherein the analysis results are used to characterize state information of the finite element analysis model under stress; Comparing the analysis result with a standard stress model in a steel plate stress model library to obtain a comparison result, and determining a target steel plate internal fixation system corresponding to the target object according to the comparison result and the initial steel plate internal fixation system, wherein the standard stress model is used to characterize stress distribution and deformation characteristics of the steel plate under different stress conditions; Wherein, generating a finite element analysis model based on the bone defect reconstruction model and the initial steel plate internal fixation system includes: The initial steel plate model and the bone defect reconstruction model are aligned, and the steel plate size and shape of the initial steel plate model are adjusted to adapt to the bone defect area in the bone defect reconstruction model; the positions and layouts of the screw holes of the initial screw arrangement model are adjusted according to the adjusted steel plate model to obtain an adjusted screw arrangement model; an adjusted steel plate internal fixation system is generated according to the adjusted steel plate model and the adjusted screw arrangement model; the adjusted steel plate internal fixation system is assembled on the bone defect reconstruction model to obtain the finite element analysis model; Finite element analysis is performed based on the finite element analysis model to obtain analysis results, including: The finite element analysis model is meshed to obtain a meshed model, wherein the meshed model is composed of a plurality of mesh elements; the HU value of each bone region in the meshed model is obtained, and the bone density value of each bone region is calculated based on the HU value of each bone region, and the elastic modulus of each bone region is calculated based on the bone density value of each bone region; the HU value and elastic modulus corresponding to each mesh element are determined based on the HU value of each bone region and the elastic modulus of each bone region, and each mesh element is assigned a value based on the HU value and elastic modulus corresponding to each mesh element to obtain a meshed model containing material properties; a finite element force analysis is performed on the meshed model containing material properties based on a first constraint condition and a second constraint condition to obtain the analysis result, wherein the first constraint condition is used to simulate the vertical pressure on the meshed model containing material properties, and the second constraint condition is used to simulate the pressure from front to back on the meshed model containing material properties, and the analysis result is stress distribution data and displacement data for each mesh element.

2. The method according to claim 1, characterized in that Determining an initial steel plate internal fixation system corresponding to the bone defect reconstruction model includes: Determining screw arrangement information according to the bone defect reconstruction model; The initial steel plate model and the initial screw arrangement model are determined from a plurality of steel plate templates in a steel plate template database according to the screw arrangement information.

3. The method according to claim 1, characterized in that The analysis result at least includes the maximum stress value that the finite element analysis model can withstand, wherein the analysis result is compared with the standard stress model in the steel plate stress model library to obtain a comparison result, including: The maximum stress value is compared with a stress value threshold in the standard stress model to obtain the comparison result.

4. The method according to claim 3, characterized in that Determining a target steel plate internal fixation system corresponding to the target object according to the comparison result and the initial steel plate internal fixation system includes: If the comparison result is that the maximum stress value is greater than the stress value threshold, adjusting the initial steel plate internal fixation system to obtain a first steel plate internal fixation system; Repeat the steps of generating a finite element analysis model based on the bone defect reconstruction model and the first steel plate internal fixation system, performing finite element analysis based on the finite element analysis model to obtain an analysis result, and comparing the analysis result with a standard force model in a steel plate force model library to obtain a comparison result, until the comparison result is that the maximum stress value is less than or equal to the stress value threshold, thereby obtaining the target steel plate internal fixation system.

5. The method according to claim 1, characterized in that: Before obtaining the bone defect reconstruction model of the target object, the method further includes: Performing geometric modeling based on the image data of the target bone to obtain a three-dimensional bone model of the target bone; Identifying a bone defect area on the three-dimensional bone model of the target bone, and determining an osteotomy line and an osteotomy area according to the bone defect area; The bone defect reconstruction model is obtained by performing simulated osteotomy on the three-dimensional bone model of the target bone according to the osteotomy line and the osteotomy area.

6. A device for determining a plate internal fixation system for bone defect reconstruction, characterized in that: include: an acquisition unit, configured to acquire a bone defect reconstruction model of a target object, and determine an initial steel plate internal fixation system corresponding to the bone defect reconstruction model, wherein the bone defect reconstruction model is obtained by simulating osteotomy of the target bone on a three-dimensional bone model of a target bone of the target object, and the initial steel plate internal fixation system at least includes an initial steel plate model and an initial screw arrangement model; A processing unit, used for generating a finite element analysis model according to the bone defect reconstruction model and the initial steel plate internal fixation system, and performing finite element analysis based on the finite element analysis model to obtain an analysis result, wherein the analysis result is used to characterize state information of the finite element analysis model under stress; a determination unit, configured to compare the analysis result with a standard stress model in a steel plate stress model library to obtain a comparison result, and determine a target steel plate internal fixation system corresponding to the target object according to the comparison result and the initial steel plate internal fixation system, wherein the standard stress model is used to characterize stress distribution and deformation characteristics of the steel plate under different stress conditions; The processing unit includes: a first processing subunit, which is used to align the initial steel plate model with the bone defect reconstruction model, and adjust the steel plate size and shape of the initial steel plate model to adapt to the bone defect area in the bone defect reconstruction model; a second processing subunit, which is used to adjust the position and layout of the screw holes of the initial screw arrangement model according to the adjusted steel plate model to obtain the adjusted screw arrangement model; a third processing subunit, which is used to generate an adjusted steel plate internal fixation system according to the adjusted steel plate model and the adjusted screw arrangement model; a fourth processing subunit, which is used to assemble the adjusted steel plate internal fixation system on the bone defect reconstruction model to obtain a finite element analysis model; The processing unit also includes: a fifth processing subunit, which is used to perform gridding processing on the finite element analysis model to obtain a gridded model, wherein the gridded model is composed of multiple grid elements; a calculation subunit, which is used to obtain the HU value of each bone area in the gridded model, and calculate the bone density value of each bone area based on the HU value of each bone area, and calculate the elastic modulus of each bone area based on the bone density value of each bone area; a sixth processing subunit, which is used to determine the HU value and elastic modulus corresponding to each grid element based on the HU value of each bone area and the elastic modulus of each bone area, and assign values ​​to each grid element based on the HU value and elastic modulus corresponding to each grid element to obtain a gridded model containing material properties; a seventh processing subunit, which is used to perform finite element force analysis on the gridded model containing material properties based on the first constraint condition and the second constraint condition to obtain an analysis result, wherein the first constraint condition is used to simulate the vertical pressure on the gridded model containing material properties, and the second constraint condition is used to simulate the pressure from front to back on the gridded model containing material properties.

7. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores a computer program, wherein the computer program is configured to execute the method for determining a steel plate internal fixation system for bone defect reconstruction as described in any one of claims 1 to 5 when running.

8. An electronic device, characterized in that: The electronic device includes one or more processors; A memory for storing one or more programs, which, when executed by the one or more processors, enables the one or more processors to run the programs, wherein the program is configured to execute the method for determining the plate internal fixation system for bone defect reconstruction as described in any one of claims 1 to 5 when running.

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