Whitening toothpaste and preparation method thereof, method for whitening teeth

Abstract

The present application relates to the field of oral care, and to a whitening toothpaste and a preparation method thereof, and a method for whitening teeth. The whitening toothpaste comprises: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers are included along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: peroxide and a first carrier acceptable to the toothpaste; the second paste comprises: a low-valent metal salt and a second carrier acceptable to the toothpaste; when used, the first paste and the second paste are contacted and mixed, and at this time, the peroxide and the low-valent metal salt undergo a Fenton-like reaction, which effectively achieves the effect of enhancing the whitening of teeth.

Description

Technical Field

[0001] The present application relates to the field of oral care, and in particular to a whitening toothpaste and a preparation method thereof, and a method for whitening teeth. Background Art

[0002] Tooth stains are divided into exogenous stains and endogenous stains. Exogenous stains refer to stains that exist in the acquired film on the tooth surface. The main reason for the formation of these stains is that there is a layer of salivary protein organic film on the tooth surface, called the acquired film on the tooth surface. When people smoke, drink tea, coffee and eat colored foods, this acquired film is easily stained by colored substances. If the stained film is not removed promptly and effectively, under the influence of various factors in the oral environment, it will form difficult-to-remove exogenous stains on the tooth surface.

[0003] There are three main ways for oral cleaning and care products to remove stains and whiten:

[0004] One is to use abrasives with high friction values ​​to remove the attachments on the tooth surface through friction.

[0005] The second is to use chelating agents to decompose, dissolve and remove stains. Active ingredients include but are not limited to: sodium phytate, tetrasodium pyrophosphate, and zinc citrate.

[0006] The third is to use active substances to whiten teeth.

[0007] According to the working principle, it can be divided into two categories: physical action and chemical action. Physical action mainly refers to various high-cleaning abrasives, which destroy the surface force of stains and enamel through efficient friction to achieve the purpose of mechanical stain removal. Chemical action ingredients mainly include polyphosphates, pyrophosphates, phytates, polyethylene glycol, etc.

[0008] The principle of its effectiveness is, on the one hand, to loosen the dense and compact tooth stains by combining with pigment stains, decompose or directly oxidize and decompose the stains; on the other hand, it can competitively adsorb on the surface of the acquired film of the teeth in the early stage of stain formation, reduce the adsorption of pigment stains, and achieve the purpose of preventing the formation of stains.

[0009] Physical whitening and chemical complex whitening are more difficult to achieve the effect of removing tooth stains, and most whitening toothpastes on the market are such whitening toothpastes.

[0010] In view of this, the present invention is proposed. Summary of the invention

[0011] The purpose of the embodiments of the present application is to provide a whitening toothpaste and a preparation method thereof, and a method for whitening teeth.

[0012] In a first aspect, the present application provides a whitening toothpaste, comprising:

[0013] An extrusion container, a first paste, and a second paste; the extrusion container includes: a container body; at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste includes: peroxide and a first carrier acceptable to toothpaste; the second paste includes: a low-valent metal salt and a second carrier acceptable to toothpaste.

[0014] The above technical solution of the present application provides a new whitening toothpaste that can effectively achieve a good whitening effect.

[0015] Further, in the above technical solution of the present application, the first paste includes: peroxide; the second paste includes: low-valent metal salt; after the peroxide contacts the low-valent metal salt, a Fenton-like reaction can occur to generate free hydroxyl groups, which act on the teeth to achieve an enhanced whitening effect. However, when the low-valent metal salt and the peroxide are in the same paste, the peroxide reacts with the low-valent metal salt in advance and becomes inactivated, and the whitening effect fails. In the above technical solution, the first paste and the second paste are each contained in a sub-chamber; this problem is effectively solved, and the whitening activity is retained. Further, when the user uses it, the first paste and the second paste in the two sub-chambers are squeezed out from the outlet onto the toothbrush (such as the bristles of a toothbrush), and the user achieves the contact and mixing of the first paste and the second paste by the action of brushing teeth. At this time, the peroxide and the low-valent metal salt undergo a Fenton-like reaction to generate free hydroxyl groups, which act on the teeth, effectively achieving an enhanced effect of whitening teeth. That is, the above technical scheme of the present application creatively proposes a "mix and use" whitening toothpaste, which effectively ensures the whitening active ingredients in the toothpaste, so that they interact with each other and release their activity during use, thereby achieving truly effective whitening, which is beneficial to enhancing the whitening effect of teeth, especially removing tooth stains and enhancing whitening efficiencies.

[0016] In other embodiments of the present application, the above-mentioned low-valent metal salt includes at least one of stannous salt, cuprous salt or ferrous salt.

[0017] In other embodiments of the present application, the stannous salt includes at least one of stannous chloride or stannous fluoride.

[0018] In other embodiments of the present application, the cuprous salt includes at least one of cuprous chloride or cuprous fluoride.

[0019] In other embodiments of the present application, the ferrous salt includes at least one of ferrous chloride, ferrous fluoride, and ferrous gluconate.

[0020] In other embodiments of the present application, the peroxide includes: at least one of hydrogen peroxide or a complex of hydrogen peroxide;

[0021] Optionally, the hydrogen peroxide complex comprises at least one of a polyvinyl pyrrolidone-hydrogen peroxide complex or urea peroxide.

[0022] In other embodiments of the present application, in the first paste, the amount of peroxide added is 2% to 18% by mass; and the content of hydrogen peroxide in the peroxide is less than 4%.

[0023] In other embodiments of the present application, in the second paste, the amount of low-valent metal salt added is 0.01% to 0.62% by mass.

[0024] In other embodiments of the present application, the first paste further includes: carboxylic acid esters;

[0025] Optionally, in the first paste, the amount of carboxylic acid ester added is 1.0% to 3.0% by mass percentage;

[0026] Optionally, the carboxylic acid esters include at least one of triacetin, ethyl acetate, propyl acetate or amyl acetate.

[0027] In other embodiments of the present application, the second paste further comprises: alkaline salts;

[0028] Optionally, in the second paste, the amount of alkaline salt added is 0.6% to 8.0% by mass percentage;

[0029] Optionally, the alkaline salt includes: at least one of a carbonate or a bicarbonate;

[0030] Optionally, the carbonate includes at least one of sodium carbonate or potassium carbonate; the bicarbonate includes at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.

[0031] In other embodiments of the present application, the second paste includes carbonate and bicarbonate;

[0032] In terms of mass percentage, in the second paste, the amount of carbonate added is 0.1% to 3.0%; the amount of bicarbonate added is 0.5% to 5%; or

[0033] The second paste includes the carbonate; in terms of mass percentage, the amount of carbonate added to the second paste is 0.1% to 8.0%; or

[0034] The second paste includes bicarbonate; in terms of mass percentage, the amount of bicarbonate added to the second paste is 0.5% to 8.0%.

[0035] In other embodiments of the present application, the first carrier includes: a friction agent, an emulsifier, a moisturizer, a thickener, and an acid-base regulator;

[0036] Optionally, the friction agent includes: at least one of calcium pyrophosphate or friction-type silica;

[0037] Optionally, the emulsifier includes: at least one of sodium methyl cocoyl taurate, alkyl glucoside, sodium lauryl sarcosinate or sodium lauryl sulfate;

[0038] Optionally, the moisturizer includes: at least one of propylene glycol, polyethylene glycols or glycerin;

[0039] Optionally, the thickener includes: at least one of thickening silicon dioxide or polyvinyl pyrrolidone;

[0040] Optionally, the acid-base regulator includes: disodium hydrogen phosphate.

[0041] In other embodiments of the present application, the first paste includes, by mass percentage:

[0042] 2%~18% peroxide; 10%-20% abrasive, 1.5%-2.5% emulsifier, 41%-60% moisturizer, 2.1%-18% thickener; 0.1%-1.0% acid-base regulator.

[0043] In other embodiments of the present application, the second carrier includes: a humectant, a thickener, an abrasive, an emulsifier, an anticaries agent;

[0044] Optionally, the moisturizer includes: at least one of glycerin, glycerol, polyethylene glycols or propylene glycol;

[0045] Optionally, the thickener includes: at least one of thickening silicon dioxide or polyvinyl pyrrolidone;

[0046] Optionally, the friction agent includes: at least one of friction-type silica or calcium pyrophosphate;

[0047] Optionally, the emulsifier includes: at least one of sodium methyl cocoyl taurate, alkyl glucoside, sodium lauryl sarcosinate or sodium lauryl sulfate;

[0048] Optionally, the anti-caries agent comprises: fluoride; Optionally, the anti-caries agent comprises: sodium fluoride.

[0049] In other embodiments of the present application, the second paste includes, by mass percentage:

[0050] 0.01%~0.62% low-valent metal salt; 67%-80% humectant, 2.1%-10% thickener, 10%-20% abrasive, 1.5%-2.5% emulsifier; 0.1%-0.32% anti-caries agent.

[0051] In other embodiments of the present application, the extrusion container further comprises: a cover plate, a transmission extrusion structure and a partition plate;

[0052] The partition is arranged in the chamber, and is used to divide the chamber into at least two sub-chambers along the extension direction of the container body, and the sub-chambers are communicated with the outlet of the container body;

[0053] The cover plate is detachably connected to the tail of the container body through a connecting structure to perform sealing;

[0054] The transmission extrusion structure is arranged in the container body and is movably connected to the cover plate. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber from the outlet.

[0055] In other embodiments of the present application, the transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is transmission-connected to the transmission member, and the transmission member drives the piston forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

[0056] In other embodiments of the present application, a whitening toothpaste includes: a base;

[0057] The base comprises: a base body;

[0058] A driving component is disposed in the base body;

[0059] The transmission structure is arranged in the base body and connected to the driving component; the transmission structure is provided with a docking component, and the docking component is used to be fixedly connected with the transmission extrusion structure in the extrusion container when the base is assembled with the extrusion container; the driving component drives the transmission structure, and then drives the transmission extrusion structure fixedly connected to the docking component to realize the extrusion of the first paste and the second paste;

[0060] A control module is disposed in the base body and is electrically connected to the driving component;

[0061] The power supply module is arranged in the base body and is electrically connected to the control module and the driving component respectively.

[0062] In other embodiments of the present application, the transmission structure includes: a bracket and a transmission member; the transmission member is arranged on the bracket, the output end of the driving member passes through the bracket, and the output end of the driving member is connected to the transmission member, and the docking member is arranged on one end of the transmission member away from the output end of the driving member.

[0063] In a second aspect, the present application provides a method for preparing a whitening toothpaste.

[0064] The whitening toothpaste comprises: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers are included along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: peroxide and a first carrier acceptable to toothpaste; the second paste comprises: a low-valent metal salt and a second carrier acceptable to toothpaste;

[0065] The first paste includes: peroxide; the second paste includes: low-valent metal salt;

[0066] The preparation method comprises:

[0067] A first paste is injected into one sub-chamber; and a second paste is injected into another sub-chamber.

[0068] In other embodiments of the present application, the low-valent metal salt includes at least one of stannous salt, cuprous salt or ferrous salt.

[0069] In a third aspect, the present application provides a method for whitening teeth.

[0070] Provided is a whitening toothpaste, comprising: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; the container body comprises at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: a peroxide and a first carrier acceptable to the toothpaste; the second paste comprises: a low-valent metal salt and a second carrier acceptable to the toothpaste;

[0071] The first paste comprises: peroxide and a first carrier acceptable to toothpaste; the second paste comprises: a low-valent metal salt and a second carrier acceptable to toothpaste;

[0072] The method includes:

[0073] When the first paste and the second paste are squeezed out, the first paste and the second paste are applied to an oral care appliance; and the oral care appliance is used to clean the oral cavity. BRIEF DESCRIPTION OF THE DRAWINGS

[0074] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0075] Figure 1 This is a schematic diagram of the structure of a whitening toothpaste according to an embodiment of the present application;

[0076] Figure 2This is a schematic structural diagram of an extrusion container according to an embodiment of the present application;

[0077] Figure 3 A structural schematic diagram of a base from one perspective of an embodiment of the present application;

[0078] Figure 4 This is a structural schematic diagram of the base from another perspective of the embodiment of the present application;

[0079] Figure 5 This is a scanning electron microscope image of the bovine tooth surface under a 1k-fold electron microscope before the plugging experiment in Comparative Example 6;

[0080] Figure 6 This is a scanning electron microscope image of the bovine tooth surface morphology corresponding to Example 1 before the plugging experiment;

[0081] Figure 7 This is a 1k-fold electron microscope image of the difference in bovine tooth surface morphology after the plugging experiment in comparative example 6;

[0082] Figure 8 This is a diagram showing the difference in surface morphology of bovine teeth under a 1k-fold electron microscope after the blocking experiment in Example 1.

[0083] Icon: 1-whitening toothpaste; 10-extrusion container; 100-container body; 200-cover; 130-partition; 110-chamber; 120-outlet; 111-subchamber; 300-connecting structure; 410-transmission member; 420-piston; 11-base; 12-base body; 13-driving member; 14-transmission structure; 15-docking member; 16-extension; 141-bracket; 142-transmission member; 800-cap body; 1500-snap assembly. DETAILED DESCRIPTION

[0084] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0085] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0086] Some embodiments of the present application provide a whitening toothpaste, comprising:

[0087] An extrusion container, a first paste, and a second paste; the extrusion container includes: a container body; at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste includes: peroxide and a first carrier acceptable to toothpaste; the second paste includes: a low-valent metal salt and a second carrier acceptable to toothpaste.

[0088] In the above technical solution, the first paste and the second paste are each contained in a sub-chamber; this problem is effectively solved and the whitening activity is retained. Furthermore, when the user uses it, the first paste and the second paste in the two sub-chambers are squeezed out from the outlet onto the toothbrush (such as the bristles of a toothbrush), and the user achieves contact and mixing of the first paste and the second paste through the action of brushing teeth. At this time, the peroxide and the low-valent metal salt undergo a Fenton-like reaction to generate free hydroxyl groups, which act on the teeth, effectively achieving the effect of enhancing the whitening of teeth. That is, the above technical solution of the present application creatively proposes a "mix and use" whitening toothpaste, which effectively ensures the whitening active ingredients in the toothpaste, so that they interact with each other during use and release their activity, thereby achieving truly effective whitening, which is beneficial to enhancing the whitening effect of teeth, especially removing tooth stains and enhancing whitening.

[0089] Reference Figure 1~Figure 4 Some embodiments of the present application provide a whitening toothpaste 1, comprising:

[0090] Extrusion container 10, first paste (not shown), second paste (not shown);

[0091] The extrusion container 10 comprises: a container body 100, a cover plate 200, a transmission extrusion structure and a partition plate 130;

[0092] The container body 100 is provided with a chamber 110, and an outlet 120 is provided on the container body 100, and the outlet 120 is communicated with the chamber 110; a partition 130 is provided in the chamber 110, and the partition 130 is used to divide the chamber 110 into at least two sub-chambers 111 along the extension direction of the container body 100, and the sub-chambers 111 are communicated with the outlet 120; the first paste and the second paste are respectively contained in one sub-chamber 111;

[0093] The cover plate 200 is detachably connected to the rear portion of the container body 100 through the connection structure 300 for sealing;

[0094] The transmission extrusion structure is disposed in the container body 100 and is movably connected to the cover plate 200. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber 110 from the outlet 120.

[0095] The first paste includes peroxide; the second paste includes low-valent metal salt.

[0096] In the above technical solution, the first paste includes: peroxide; the second paste includes: low-valent metal salt; after the peroxide contacts the low-valent metal salt, a Fenton-like reaction can occur to generate free hydroxyl groups, which act on the teeth to achieve an enhanced whitening effect. However, when the low-valent metal salt and the peroxide are in the same paste, the peroxide reacts with the low-valent metal salt in advance and becomes inactivated. In the above technical solution, the first paste and the second paste are each contained in a sub-chamber; this problem is effectively solved and the whitening activity is retained. Furthermore, when the user uses it, the transmission extrusion structure squeezes the first paste and the second paste in the two sub-chambers from the outlet to the toothbrush (such as the bristles of a toothbrush), and the user achieves the contact and mixing of the first paste and the second paste through the action of brushing teeth. At this time, the peroxide and the low-valent metal salt undergo a Fenton-like reaction to generate free hydroxyl groups, which act on the teeth, effectively achieving an enhanced whitening effect on the teeth. That is, the above technical scheme of the present application creatively proposes a "mix and use" whitening toothpaste, which effectively ensures the whitening active ingredients in the toothpaste, so that they interact with each other and release their activity during use, thereby achieving truly effective whitening and helping to enhance the whitening effect of teeth.

[0097] For example, taking hydrogen peroxide as an example, the above peroxide and low-valent metal salt undergo a Fenton-like reaction, and the reaction formula is as follows:

[0098]

[0099] Furthermore, in the above technical solution, the first paste and the second paste in the chamber 110 are sealed by connecting the cover plate 200 to the tail of the extrusion container 10. By arranging a transmission extrusion structure for extruding the first paste and the second paste in the container body 100, relying on the connection between the cover plate 200 and the transmission extrusion structure, the cover plate 200 can play a role in positioning and supporting the transmission extrusion structure in the process of extruding the material from the outlet, so that the transmission extrusion structure can extrude the first paste and the second paste from the outlet more stably and efficiently. The sealing effect of the cover plate 200 can improve the problem of leakage of the first paste and the second paste from the chamber 110 when the transmission extrusion structure extrude the first paste and the second paste, reduce the risk of failure of the extrusion container 10, and improve the working efficiency of the extrusion container 10 in extruding the first paste and the second paste.

[0100] Furthermore, in the above technical solution, the first paste and the second paste are squeezed out from the outlet of the chamber 110 to form a complete and shaped paste (the first paste and the second paste are in contact and connected together, but can be clearly distinguished); during the use stage, it can ensure that the user applies the first paste and the second paste in the oral cavity at the same time, and it is more conducive to the uniform mixing of the first paste and the second paste in the oral cavity; it can also utilize the release of active ingredients in the oral cavity, which is more conducive to the whitening effect.

[0101] Furthermore, in the above technical solution, the first paste and the second paste are "mixed and used immediately", which is gentler, more suitable for the oral environment, and more conducive to protecting the oral mucosa. Assuming a scenario, only a single tube of ordinary whitening toothpaste containing peroxide is used, and low-valent metal salts (such as powder or solution) are added to the ordinary single tube peroxide toothpaste during the use stage; this form will cause greater irritation, which is not conducive to the oral mucosa; it also makes it very troublesome to use, and the actual application value is greatly reduced; once again, assuming another scenario, two active substances (such as peroxide and low-valent metal salt powder or solution) are directly used in the oral cavity; this will inevitably lead to very large irritation, which is very unfavorable to the oral mucosa, and it also makes it very troublesome to use, and the actual application value is greatly reduced.

[0102] Further optionally, in some embodiments of the present application, the sub-chambers 111 are provided in two, and the first paste and the second paste are each contained in one sub-chamber 111 .

[0103] In other optional embodiments of the present application, the above-mentioned sub-chambers 111 can be optionally set to three, four or five, etc., but the first paste and the second paste are always located in two independent sub-chambers 111; the remaining sub-chambers 111 can be set according to actual needs; illustratively, other sub-chambers 111 can accommodate other pastes; or other non-paste materials (such as water, etc.); or blank settings (for example, they can be left empty for personalized use by users, etc.).

[0104] Furthermore, in some embodiments of the present application, the low-valent metal salt includes at least one of stannous salt, cuprous salt or ferrous salt.

[0105] Illustratively, in some embodiments of the present application, the above-mentioned low-valent metal salt is any one of stannous salt, cuprous salt or ferrous salt; or in some embodiments of the present application, the above-mentioned low-valent metal salt is a mixture of stannous salt and cuprous salt; or in some embodiments of the present application, the above-mentioned low-valent metal salt is a mixture of stannous salt and ferrous salt; or in some embodiments of the present application, the above-mentioned low-valent metal salt is a mixture of cuprous salt and ferrous salt; the raw materials in the above-mentioned mixtures can be mixed in any proportion.

[0106] The stannous salt, cuprous salt or ferrous salt in the above technical solution can undergo a Fenton-like reaction after contacting with peroxide to generate free hydroxyl groups, which act on teeth to achieve an enhanced whitening effect.

[0107] For example, taking stannous salt as an example, when stannous salt contacts peroxide, the following Fenton-like reaction can occur:

[0108]

[0109] From the above reaction, it can be seen that after stannous salt comes into contact with peroxide, a Fenton-like reaction occurs to generate free hydroxyl groups, which can effectively enhance the whitening effect on teeth, thereby effectively improving the whitening effect of teeth.

[0110] Furthermore, in some embodiments of the present application, the stannous salt includes at least one of stannous chloride or stannous fluoride.

[0111] For example, in some embodiments of the present application, the stannous salt is selected from: any one of stannous chloride or stannous fluoride; or in some embodiments of the present application, the stannous salt is selected from: a mixture of stannous chloride and stannous fluoride; the two can be mixed in any proportion in the mixture.

[0112] Furthermore, in some embodiments of the present application, the cuprous salt includes at least one of cuprous chloride or cuprous fluoride.

[0113] Illustratively, in some embodiments of the present application, the cuprous salt is selected from: any one of cuprous chloride or cuprous fluoride; or in some embodiments of the present application, the cuprous salt is selected from: a mixture of cuprous chloride and cuprous fluoride; the two can be mixed in any proportion in the mixture.

[0114] Furthermore, in some embodiments of the present application, the ferrous salt includes at least one of ferrous chloride, ferrous fluoride, and ferrous gluconate.

[0115] Illustratively, in some embodiments of the present application, the ferrous salt is selected from: any one of ferrous chloride, ferrous fluoride, and ferrous gluconate; or in some embodiments of the present application, the ferrous salt is selected from: a mixture of ferrous chloride and ferrous fluoride; or in some embodiments of the present application, the ferrous salt is selected from: a mixture of ferrous fluoride and ferrous gluconate; or in some embodiments of the present application, the ferrous salt is selected from: a mixture of ferrous chloride and ferrous gluconate; or in some embodiments of the present application, the ferrous salt is selected from: a mixture of ferrous chloride and ferrous gluconate; or in some embodiments of the present application, the ferrous salt is selected from: a mixture of ferrous chloride, ferrous fluoride, and ferrous gluconate; the raw materials in the mixture can be mixed in any proportion.

[0116] Furthermore, in some embodiments of the present application, the peroxide includes at least one of hydrogen peroxide or a complex of hydrogen peroxide.

[0117] For example, in some embodiments of the present application, the peroxide includes: any one of hydrogen peroxide or a complex of hydrogen peroxide; or in some embodiments of the present application, the peroxide includes: a mixture of hydrogen peroxide and a complex of hydrogen peroxide; the individual raw materials in the mixture can be mixed in any proportion.

[0118] Furthermore, in some embodiments of the present application, the hydrogen peroxide complex includes at least one of a polyvinyl pyrrolidone-hydrogen peroxide complex or urea peroxide.

[0119] Illustratively, in some embodiments of the present application, the hydrogen peroxide complex is selected from: any one of polyvinyl pyrrolidone-hydrogen peroxide complex or urea peroxide; or in some embodiments of the present application, the above-mentioned hydrogen peroxide complex is selected from: a mixture of polyvinyl pyrrolidone-hydrogen peroxide complex and urea peroxide; the various raw materials in the mixture can be mixed in any proportion.

[0120] Furthermore, in some embodiments of the present application, the content of hydrogen peroxide in the peroxide is less than 4% by mass; in the first paste, the amount of peroxide added is 2% to 18%.

[0121] Peroxide has excellent bleaching, disinfection, deodorization and other functions, and can be used for cold light whitening of teeth in oral medicine. However, if the amount added is too large, it is easy to cause adverse reactions such as tooth erosion sensitivity and oral mucosal shedding. Therefore, high-concentration hydrogen peroxide oral whitening products are used in the medical industry, and the use process and dosage are controlled by doctors. However, even when low-concentration hydrogen peroxide (less than 4%) is used in toothpaste as a whitening ingredient, relevant regulations clearly limit its maximum usage. However, some product developers still use peroxide close to the maximum amount in toothpaste in pursuit of good whitening effects, which poses a risk of oral mucosal shedding.

[0122] In the above technical scheme of the present application, in order to achieve the same or better whitening effect under low-concentration peroxide conditions, a "mix and use" scheme of peroxide and low-valent metal salt is adopted, which increases the conversion rate of low-concentration hydrogen peroxide to release peroxyl free radicals and free hydroxyl groups, thereby improving the bleaching and whitening ability of oral care products, and has the effect of mineralizing and repairing damaged enamel.

[0123] In the above technical solution, by setting the amount of peroxide added in the first paste to 2%~18%, it is not only beneficial to improve the whitening effect; more importantly, it can achieve an enhanced whitening effect within a low concentration range (for example, the amount of peroxide added can be reduced to 2%, and a good whitening effect can still be achieved).

[0124] Further optionally, exemplarily, in some embodiments of the present application, in the first paste, the amount of peroxide added is 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.5%, 5%, 10%, 15%, 18% or a range between any two of the foregoing values, measured in mass percentage.

[0125] It should be noted that in some embodiments of the present application, in the first paste, the content of hydrogen peroxide is calculated as the content of hydrogen peroxide, and the content of hydrogen peroxide in the peroxide is less than 4% by mass percentage. It can be converted according to the selected raw materials and the performance of the raw materials. Exemplarily, when the raw material of the peroxide selects a commercially available PVP-hydrogen peroxide complex with a content of 20% of hydrogen peroxide, the content of hydrogen peroxide in the PVP-hydrogen peroxide complex is 0.4%~3.6%. Further exemplary, the content of hydrogen peroxide is 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 2%, 2.5%, 3% or the range between any two of the aforementioned values.

[0126] Furthermore, in some embodiments of the present application, in the second paste, the amount of low-valent metal salt added is 0.01% to 0.62% by mass.

[0127] In the above technical solution, the added amount of the low-valent metal salt in the second paste is 0.01%~0.62%; it can further achieve synergistic effect with the peroxide in the first paste when "mix and use" is achieved, and exert an enhanced whitening effect.

[0128] Illustratively, in some embodiments of the present application, the amount of low-valent metal salt added is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.1%, 0.2%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.60%, 0.62% or a range between any two of the foregoing values.

[0129] Furthermore, in some embodiments of the present application, the first paste includes: carboxylates.

[0130] Carboxylates and peroxides do not react in the absence of water, but will react with water to produce peracetic acid when used. Peracetic acid has a stronger oxidizing property than hydrogen peroxide, which improves the whitening effect. At the same time, peracetic acid is unstable and easily decomposes to produce free radicals. Free radicals oxidize colored substances, causing them to lose their color, further improving the teeth whitening effect.

[0131] The reaction formula is exemplified as follows:

[0132]

[0133] Furthermore, in some embodiments of the present application, the carboxylic acid esters include at least one of triacetin, ethyl acetate, propyl acetate or pentyl acetate.

[0134] The following uses triacetin as an example to illustrate the synergistic effect between triacetin and peroxide to improve the whitening effect:

[0135]

[0136] In the above reaction, the two do not react in the absence of water. In the presence of water, the peracetic acid produced after the two reactions has a stronger oxidizing property than hydrogen peroxide. The low-concentration peracetic acid produced is unstable and easily decomposed to produce efficient free radicals. These free radicals can be used to oxidize colored organic matter, causing it to lose color by bleaching; when using the whitening toothpaste of the present application, there is water in the mouth, and the first paste and the second paste are mixed when brushing teeth, so that the carboxylic acid esters and peroxides react in the presence of water to generate peracetic acid. The formed peracetic acid is more effective in bleaching teeth, so that an effective bleaching effect can be achieved in a shorter time and at a lower level of peroxide; at the same time, peracetic acid is unstable and easily decomposed to produce free radicals, which can oxidize colored substances on teeth, causing them to lose color, further improving the teeth whitening effect.

[0137] The reaction between hydrogen peroxide and carboxylic acid esters can only occur in the presence of water. In the absence of water, the two do not react. However, when carboxylic acid esters are mixed with alkaline substances for a long time, there will be a hydrolysis reaction, which will lead to an unstable formula. Therefore, setting the two to "mix and use" can effectively solve this problem.

[0138] Further optionally, illustratively, in some embodiments of the present application, the above-mentioned carboxylic acid esters are selected from: any one of triacetin, ethyl acetate, propyl acetate or amyl acetate; or in some embodiments of the present application, the above-mentioned carboxylic acid esters are selected from: a mixture of triacetin and ethyl acetate; or in some embodiments of the present application, the above-mentioned carboxylic acid esters are selected from: a mixture of triacetin and propyl acetate; or in some embodiments of the present application, the above-mentioned carboxylic acid esters are selected from: a mixture of triacetin and amyl acetate; or in some embodiments of the present application, the above-mentioned carboxylic acid esters are selected from: a mixture of triacetin, ethyl acetate and propyl acetate; or in some embodiments of the present application, the above-mentioned carboxylic acid esters are selected from: a mixture of triacetin, ethyl acetate, propyl acetate and amyl acetate; the raw materials in the mixture can be mixed in any proportion.

[0139] Furthermore, in some embodiments of the present application, in the first paste, the amount of carboxylic acid ester added is 1.0% to 3.0% by mass.

[0140] In the above technical solution, in the first paste, the added amount of carboxylic acid esters is 1.0%~3.0%; it can further synergize with the aforementioned peroxide to further improve the whitening effect.

[0141] Further optionally, in some embodiments of the present application, illustratively, in the first paste, the amount of carboxylic acid ester added is 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0% or a range between any two of the foregoing values.

[0142] Furthermore, in some embodiments of the present application, the second paste includes: alkaline salts.

[0143] The alkaline salts and peroxides are respectively arranged in two pastes, which can ensure the whitening effect of the peroxides and alkaline salts themselves, and can be "mixed and used immediately". The reaction of the two can generate peroxyl free radicals, which enhances the whitening effect compared with single hydrogen peroxide, and is conducive to further improving the whitening effect; and the high-valent metal ions generated by the alkaline salts and the Fenton-like reaction generate precipitates, which have a blocking effect on the dental tubules and increase the hardness of the enamel, so that the whitening toothpaste of the present application also has the effect of mineralizing and repairing damaged enamel.

[0144] Further optionally, in some embodiments of the present application, the alkaline salt includes: at least one of carbonate or bicarbonate.

[0145] Carbonates or bicarbonates themselves have whitening effects, which is helpful to further improve the whitening effect; further, the combination of carbonates and bicarbonates is helpful to prevent flatulence and extend the shelf life of toothpaste.

[0146] Exemplarily, the reaction of the above-mentioned alkaline salts with peroxide is as follows:

[0147]

[0148] As can be seen from the above reaction formula, hydrogen peroxide reacts with sodium bicarbonate to generate peroxyl radicals, which enhances the whitening effect compared to single hydrogen peroxide. Further optionally, illustratively, in some embodiments of the present application, the alkaline salt is selected as: any one of carbonate or bicarbonate; or in some embodiments of the present application, the alkaline salt is selected as: a mixture of carbonate and bicarbonate; each raw material in the mixture can be mixed in any proportion.

[0149] Furthermore, in some embodiments of the present application, the carbonate includes at least one of sodium carbonate or potassium carbonate; the bicarbonate includes at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.

[0150] For example, in some embodiments of the present application, the carbonate is selected from either sodium carbonate or potassium carbonate; or in some embodiments of the present application, the carbonate is selected from a mixture of sodium carbonate and potassium carbonate; the raw materials in the mixture can be mixed in any proportion.

[0151] For example, in some embodiments of the present application, the bicarbonate is selected from any one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate. Or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate and calcium bicarbonate; or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of sodium bicarbonate and potassium bicarbonate; or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of magnesium bicarbonate and calcium bicarbonate; or in some embodiments of the present application, the above-mentioned bicarbonate is selected from a mixture of sodium bicarbonate, potassium bicarbonate and magnesium bicarbonate; each raw material in the mixture can be mixed in any proportion.

[0152] Furthermore, in some embodiments of the present application, the amount of alkaline salt added to the second paste is 0.6% to 3.5% by mass.

[0153] In the above technical solution, the amount of alkaline salt added to the second paste is 0.6%~3.5%, which can further synergize with the aforementioned peroxide to further improve the whitening effect.

[0154] Illustratively, in some embodiments of the present application, the amount of alkaline salt added is 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.5%, 1.6%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5% or a range between any two of the foregoing values.

[0155] Furthermore, in some embodiments of the present application, in the second paste, the amount of carbonate added is 0.1% to 8.0% by mass.

[0156] In the above technical solution, in the second paste, the added amount of carbonate is 0.1%~8.0%; it can further synergize with other raw materials such as the aforementioned peroxide to further improve the whitening effect.

[0157] Further, in some embodiments of the present application, the second paste includes the carbonate and the bicarbonate;

[0158] In terms of mass percentage, in the second paste, the added amount of the carbonate is 0.1% to 3.0%; the added amount of the bicarbonate is 0.5% to 5%.

[0159] In the above technical solution, in the second paste, carbonates and bicarbonates can further synergize with other raw materials such as the aforementioned peroxide to further enhance the whitening effect.

[0160] Exemplarily, in some embodiments of the present application, in terms of mass percentage, in the second paste, the addition amount of carbonate is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0% or the range between any two of the foregoing values. Exemplarily, in some embodiments of the present application, in terms of mass percentage, in the second paste, the addition amount of bicarbonate is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5% or the range between any two of the foregoing values.

[0161] Furthermore, in some embodiments of the present application, the second paste includes the carbonate; in terms of mass percentage, the added amount of the carbonate in the second paste is 0.1% to 8.0%.

[0162] Furthermore, in some embodiments of the present application, the second paste includes the bicarbonate; in the second paste, the amount of the bicarbonate added is 0.5% to 8.0% by mass.

[0163] Illustratively, in some embodiments of the present application, in the second paste, the amount of bicarbonate added is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5% or a range between any two of the foregoing values, in percentage by mass.

[0164] Furthermore, in some embodiments of the present application, the first carrier includes: a friction agent, an emulsifier, a moisturizer, a thickener, and an acid-base regulator.

[0165] Furthermore, in some embodiments of the present application, optionally, the friction agent includes: at least one of calcium pyrophosphate or friction-type silica.

[0166] Further, in some embodiments of the present application, optionally, the emulsifier includes: at least one of sodium methyl cocoyl taurate, alkyl glucoside, sodium lauryl sarcosinate or sodium lauryl sulfate.

[0167] Furthermore, in some embodiments of the present application, optionally, the moisturizer includes: at least one of propylene glycol, polyethylene glycols or glycerin.

[0168] Furthermore, in some embodiments of the present application, optionally, the thickener includes: at least one of thickening silicon dioxide or polyvinyl pyrrolidone.

[0169] Further, in some embodiments of the present application, optionally, the acid-base regulator includes: disodium hydrogen phosphate.

[0170] Illustratively, in some embodiments of the present application, the first paste includes: calcium pyrophosphate, sodium methyl cocoyl taurate, propylene glycol, PVP-hydrogen peroxide complex, polyvinyl pyrrolidone, triacetin, thickening silica, disodium hydrogen phosphate, and PEG-1500.

[0171] Further, in some embodiments of the present application, the first paste includes, by mass percentage:

[0172] 2%~18% peroxide; 10%-20% abrasive, 1.5%-2.5% emulsifier, 41%-60% moisturizer, 2.1%-18% thickener; 0.1%-1.0% acid-base regulator.

[0173] Exemplarily, in terms of mass percentage, the first paste includes:

[0174] 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18% or a range between any two of the foregoing peroxides;

[0175] 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20% or a range between any two of the foregoing friction agent; 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5% or a range between any two of the foregoing emulsifier; 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 50%, 52%, 53%, 55%, 56%, 58%, 60% or a range between any two of the foregoing moisturizers; 2.1%, 2.2%, 2.5%, 3%, 5%, 8%, 10%, 12%, 15%, 18% or a range between any two of the foregoing thickeners; 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0% or a range between any two of the foregoing acid-base regulators.

[0176] Furthermore, in some embodiments of the present application, the second carrier includes: a moisturizer, a thickener, an abrasive, an emulsifier, and an anti-caries agent.

[0177] Furthermore, in some embodiments of the present application, optionally, the moisturizer includes: at least one of glycerin, glycerol, polyethylene glycols or propylene glycol.

[0178] Furthermore, in some embodiments of the present application, optionally, the thickener includes: at least one of thickening silicon dioxide or polyvinyl pyrrolidone.

[0179] Furthermore, in some embodiments of the present application, optionally, the friction agent includes: at least one of friction-type silica or calcium pyrophosphate.

[0180] Further, in some embodiments of the present application, optionally, the emulsifier includes: at least one of sodium methyl cocoyl taurate, alkyl glucoside, sodium lauryl sarcosinate or sodium lauryl sulfate.

[0181] Further, in some embodiments of the present application, optionally, the anti-caries agent includes: fluoride; optionally, the anti-caries agent includes: sodium fluoride.

[0182] Further, in some embodiments of the present application, the second paste includes, by mass percentage:

[0183] 0.01%~0.62% low-valent metal salt; 67%-80% humectant, 2.1%-10% thickener, 10%-20% abrasive, 1.5%-2.5% emulsifier; 0.1%-0.32% anti-caries agent.

[0184] For example, in some embodiments of the present application, the second paste includes, by mass percentage:

[0185] 0.01%, 0.02%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.62% or a range between any two of the foregoing low-valent metal salts;

[0186] 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80% or a range between any two of the foregoing humectants; 2.1%, 2.2%, 2.5%, 2.8%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or a range between any two of the foregoing thickeners; 10%, 12%, 15%, 18%, 20% or a range between any two of the foregoing 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4% or 2.5% emulsifier in the range between any two of the foregoing values; 0.1%, 0.12%, 0.15%, 0.18%, 0.19%, 0.2%, 0.22%, 0.23%, 0.25%, 0.28%, 0.3%, 0.32% or an anti-caries agent in the range between any two of the foregoing values.

[0187] Illustratively, in some embodiments of the present application, the second paste includes: glycerin (propylene glycol), polyethylene glycol-8, thickening silica, friction silica, sodium methyl cocoyl taurate, polyvinyl pyrrolidone, stannous chloride, sodium fluoride, sodium carbonate, and baking soda.

[0188] Further optionally, in some embodiments of the present application, the first paste and the second paste may also include: sweeteners; such as: mannitol, sucralose, trichlorogalactose; and flavors.

[0189] Further optionally, the first paste includes, by mass percentage: 0.08-0.2% sucralose; 1-15% mannitol; and 0.8-1.4% flavor.

[0190] Further optionally, the second paste includes, by mass percentage: 0.08-0.2% of galactose added; and 0.8-1.4% of flavor added.

[0191] Furthermore, in some embodiments of the present application, the transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is connected to the transmission member, and the transmission member drives the piston forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

[0192] Please refer to Figure 2 As shown, in some embodiments of the present application, the transmission extrusion structure includes: a transmission member 410 and a piston 420, one end of the transmission member 410 is movably connected to the cover plate 200, the transmission member 410 is arranged in the chamber 110 along the extension direction of the container body 100, the piston 420 is transmission-connected to the transmission member 410, and the transmission member 410 drives the piston 420 to move forward or backward along the axial extension direction of the transmission member 410 to realize the extrusion of the material.

[0193] In this embodiment, the piston 420 can be driven forward or backward along the axial extension direction of the transmission member 410 by the forward and reverse transmission of the transmission member 410 in the transmission extrusion structure, thereby realizing automatic extrusion of the material in the chamber 110 by the piston 420.

[0194] by Figure 1~Figure 2 Taking the structure of the extrusion container 10 shown as an example, since a partition 130 is provided in the container body 100, the chamber 110 of the container body 100 is divided into two to form two independent sub-chambers 111, and each sub-chamber 111 is used to contain the first paste and the second paste. In order to realize the automatic synchronous extrusion of the toothpaste paste in the two sub-chambers 111 and achieve the purpose of mixing and using, the transmission extrusion structure in this embodiment includes two transmission members 410 and two pistons 420, and each sub-chamber 111 is respectively provided with a transmission member 410 and a piston 420, and the two transmission members 410 can rotate synchronously, thereby driving the two pistons 420 to realize synchronous forward or backward movement, and finally realizing the automatic synchronous extrusion of the toothpaste paste of different components in the two sub-chambers 111.

[0195] In some embodiments of the present application, the transmission extrusion structure may be an electric push rod, at the end of which a piston 420 is disposed, and the electric push rod pushes the piston 420 forward or backward to achieve automatic extrusion of the toothpaste paste.

[0196] Further, refer to Figure 3~Figure 4 In some embodiments of the present application, the whitening toothpaste includes: a base 11;

[0197] The base 11 includes: a base body 12;

[0198] A driving component 13 is disposed in the base body 12;

[0199] The transmission structure 14 is arranged in the base body 12 and connected to the driving component 13; the transmission structure 14 is provided with a docking component 15, and the docking component 15 is used to be fixedly connected with the transmission extrusion structure in the extrusion container 10 when the base 11 and the extrusion container 10 are assembled; the driving component 13 drives the transmission structure 14, and then drives the transmission extrusion structure fixedly connected to the docking component 15, so as to realize the extrusion of the first paste and the second paste;

[0200] The control module is disposed in the base body 12 and is electrically connected to the driving component 13;

[0201] The power supply module is disposed in the base body 12 and is electrically connected to the control module and the driving component 13 respectively.

[0202] Furthermore, in some embodiments of the present application, the transmission structure 14 includes: a bracket 141 and a transmission member 142; the transmission member 142 is arranged on the bracket 141, the output end of the driving component 13 passes through the bracket 141, and the output end of the driving component 13 is connected to the transmission member 142, and the docking component 15 is arranged on one end of the transmission member 142 away from the output end of the driving component 13.

[0203] Please refer to Figure 1~Figure 4 As shown, a switch is provided on the container body 100, and a plug-in component is provided on the container body. The switch is electrically connected to the plug-in component, and the plug-in component is used to electrically connect with a conductive component on a base mounted in cooperation with the extrusion container 10 to transmit an electrical signal.

[0204] In some embodiments of the present application, after the base and the extrusion container 10 are installed, the driving structure is docked with the transmission extrusion structure in the extrusion container 10. After the user triggers the switch, the circuit between the extrusion container 10 and the base is turned on. The control module sends a control instruction to the driving structure according to the switch signal triggered by the user. The driving structure receives the instruction and drives the transmission extrusion structure to work, and the piston is pushed forward by the rotation of the transmission member 410, thereby realizing the automatic and synchronous extrusion of the first paste and the second paste.

[0205] In some embodiments of the present application, the whitening toothpaste 1 further includes: a cap body 800 , and the cap body 800 is connected to the container body 100 .

[0206] In some embodiments of the present application, a snap assembly 1500 is provided on the base body 12 , and the base body 12 is detachably connected to the extrusion container via the snap assembly 1500 .

[0207] In some embodiments of the present application, an extension portion 16 is provided on the base body 12 , a switch and a plug-in component are provided on the extension portion 16 , and the switch is provided on the extension portion 16 and on one end close to the outlet of the extrusion container.

[0208] Some embodiments of the present application provide a method for preparing a whitening toothpaste.

[0209] The whitening toothpaste comprises: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers are included along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: peroxide and a first carrier acceptable to toothpaste; the second paste comprises: a low-valent metal salt and a second carrier acceptable to toothpaste;

[0210] The preparation method comprises:

[0211] A first paste is injected into one sub-chamber; and a second paste is injected into another sub-chamber.

[0212] In some embodiments of the present application, the above-mentioned low-valent metal salt includes at least one of stannous salt, cuprous salt or ferrous salt.

[0213] Some embodiments of the present application provide a method for whitening teeth.

[0214] Provided is a whitening toothpaste, comprising: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; the container body comprises at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: a peroxide and a first carrier acceptable to the toothpaste; the second paste comprises: a low-valent metal salt and a second carrier acceptable to the toothpaste;

[0215] Methods include:

[0216] When the first paste and the second paste are squeezed out from the outlet, the first paste and the second paste are applied to an oral care appliance; and the oral care appliance is used to clean the oral cavity.

[0217] Some embodiments of the present application provide an extrusion container, a first paste, and a second paste;

[0218] The extrusion container comprises: a container body;

[0219] The container body is provided with a chamber, and the container body is provided with an outlet, which is communicated with the chamber; the chamber includes at least two sub-chambers along the extension direction of the container body, and the sub-chambers are communicated with the outlet; the first paste and the second paste are respectively contained in one sub-chamber;

[0220] The first paste comprises: peroxide and a first carrier acceptable to toothpaste; the second paste comprises: a low-valent metal salt and a second carrier acceptable to toothpaste.

[0221] In the above technical solution, the first paste and the second paste can be extruded by an extrusion mechanism or manually.

[0222] The features and properties of the present application are further described in detail below in conjunction with the examples. The various raw materials used in the examples can be purchased commercially; the preparation of the first paste and the second paste can adopt the conventional toothpaste paste preparation process in the art.

[0223] Embodiment 1:

[0224] Provided is a whitening toothpaste, comprising: an extrusion container, a base, a first paste, and a second paste; the extrusion container and the base are as follows Figure 1-Figure 4 The first paste and the second paste are injected into two sub-chambers of the extrusion container and sealed.

[0225] The composition of the first paste is: propylene glycol 47.82wt.%, polyvinyl pyrrolidone 1.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) 5wt.%, disodium hydrogen phosphate 0.12wt.%, PEG-1500 3wt.%, triacetin 2.5wt.%.

[0226] The composition of the second paste is: glycerin 48.46wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 19wt.%, galactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinyl pyrrolidone 0.8wt.%, stannous chloride 0.3wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%, sodium carbonate 1.5wt.%, baking soda 1.5wt.%.

[0227] Embodiment 2:

[0228] The difference from Example 1 is that the compositions of the first paste and the second paste are different:

[0229] The composition of the first paste is: propylene glycol 52.1wt.%, polyvinyl pyrrolidone 0.5wt.%, trichlorogalactose 0.1wt.%, sodium methyl cocoyl taurate 1.5wt.%, flavor 1.0wt.%, anhydrous calcium pyrophosphate 10wt.%, mannitol 20wt.%, colloidal silica 9.8wt.%, PVP-H2O2 complex (hydrogen peroxide content 20wt.%) 2wt.%, disodium hydrogen phosphate 1.0wt.%, PEG-1500 1wt.%, triacetin 1wt.%.

[0230] The composition of the second paste is: glycerin 46.53wt.%, PEG-400 25wt.%, silica (thickening type) 8wt.%, silica (friction type) 16wt.%, galactose 0.12wt.%, sodium methyl cocoyl taurate 2.0wt.%, polyvinyl pyrrolidone 0.1wt.%, stannous chloride 0.45wt.%, sodium fluoride 0.1wt.%, flavor 1.1wt.%, sodium carbonate 0.1wt.%, baking soda 0.5wt.%.

[0231] Embodiment 3:

[0232] The difference from Example 1 is that the compositions of the first paste and the second paste are different:

[0233] The composition of the first paste is: propylene glycol 44.82wt.%, polyvinyl pyrrolidone 8.0wt.%, trichlorogalactose 0.08wt.%, sodium methyl cocoyl taurate 2.5wt.%, flavor 1.5wt.%, anhydrous calcium pyrophosphate 13wt.%, mannitol 5wt.%, colloidal silica 1wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) 15wt.%, disodium hydrogen phosphate 0.1wt.%, PEG-1500 4wt.%, and triacetin 5wt.%.

[0234] The composition of the second paste is: glycerin 54.49wt.%, PEG-400 12wt.%, silica (thickening type) 2wt.%, silica (friction type) 25wt.%, galactose 0.2wt.%, sodium methyl cocoyl taurate 2.5wt.%, polyvinyl pyrrolidone 2.0wt.%, stannous chloride 0.01wt.%, sodium fluoride 0.1wt.%, flavor 1.1wt.%, sodium carbonate 0.1wt.%, baking soda 0.5wt.%.

[0235] Embodiment 4:

[0236] The difference from Example 1 is that the compositions of the first paste and the second paste are different:

[0237] The composition of the first paste is: propylene glycol 45.3wt.%, polyvinyl pyrrolidone 2wt.%, trichlorogalactose 0.1wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1.5wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 12wt.%, colloidal silica 5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) 10wt.%, disodium hydrogen phosphate 0.1wt.%, PEG-1500 4wt.%, triacetin 3wt.%.

[0238] The composition of the second paste is: glycerin 46.12wt.%, PEG-400 18wt.%, silica (thickening type) 5wt.%, silica (friction type) 20wt.%, trichlorogalactose 0.18wt.%, sodium methyl cocoyl taurate 2.1wt.%, polyvinyl pyrrolidone 1.1wt.%, stannous chloride 0.2wt.%, sodium fluoride 0.2wt.%, flavor 1.1wt.%, sodium carbonate 2wt.%, baking soda 4wt.%.

[0239] Embodiment 5:

[0240] The difference from Example 1 is that in the first paste, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 2wt.%, PEG-1500 is 2wt.%, propylene glycol is 51.82wt.%, and the remaining raw materials are the same as in Example 1 and will not be repeated here.

[0241] Embodiment 6:

[0242] The difference from Example 1 is that in the first paste, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 18wt.%, PEG-1500 is 1wt.%, propylene glycol is 37.82wt.%, anhydrous calcium pyrophosphate is 14wt.%, and the remaining raw materials are the same as in Example 1 and will not be repeated here.

[0243] Embodiment 7:

[0244] The difference from Example 1 is that in the first paste, the PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 0.5wt.%, anhydrous calcium pyrophosphate is 16.5wt.%, propylene glycol is 52.82wt.%, and the remaining raw materials are the same as in Example 1 and will not be repeated here.

[0245] Embodiment 8:

[0246] The first paste is composed of:

[0247] Propylene glycol 50.32wt.%, polyvinyl pyrrolidone 1.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 5wt.%, disodium hydrogen phosphate is 0.12wt.%, and PEG-1500 is 3wt.%.

[0248] The second paste is composed of:

[0249] Glycerin 48.15wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 22wt.%, galactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinyl pyrrolidone 0.8wt.%, stannous chloride 0.3 wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%.

[0250] Embodiment 9:

[0251] The difference from Example 1 is that the composition of the second paste is:

[0252] Glycerin 48.15wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 22wt.%, galactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinyl pyrrolidone 0.8wt.%, stannous chloride 0.3 wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%.

[0253] Embodiment 10:

[0254] The difference from Example 1 is that the first paste consists of:

[0255] Propylene glycol 50.32wt.%, polyvinyl pyrrolidone 1.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 5wt.%, disodium hydrogen phosphate is 0.12wt.%, and PEG-1500 is 3wt.%.

[0256] Comparative Example 1:

[0257] The first paste is composed of:

[0258] Propylene glycol 50.32wt.%, polyvinyl pyrrolidone 6.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, disodium hydrogen phosphate 0.12wt.%, PEG-1500 3wt.%.

[0259] The second paste composition is: glycerin 51.45wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 19wt.%, trichlorogalactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinyl pyrrolidone 0.8wt.%, sodium fluoride 0.31wt.%, and flavor 1.1wt.%.

[0260] Comparative Example 2:

[0261] The first paste is composed of:

[0262] Propylene glycol 50.32wt.%, polyvinyl pyrrolidone 1.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 5wt.%, disodium hydrogen phosphate is 0.12wt.%, and PEG-1500 is 3wt.%.

[0263] The second paste is composed of:

[0264] Propylene glycol 47.82wt.%, polyvinyl pyrrolidone 6.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, disodium hydrogen phosphate 0.12wt.%, PEG-1500 3wt.%, triacetin 2.5wt.%.

[0265] Comparative Example 3:

[0266] The first paste is composed of:

[0267] Propylene glycol 50.32wt.%, polyvinyl pyrrolidone 1.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 5wt.%, disodium hydrogen phosphate is 0.12wt.%, and PEG-1500 is 3wt.%.

[0268] The second paste is composed of:

[0269] Glycerin 48.45wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 19wt.% ((silicon dioxide (ordinary friction type) 12 wt.%, silica (high friction type) 7 wt.%)), trichlorogalactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinylpyrrolidone 0.8wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%, sodium carbonate 1.5wt.%, baking soda 1.5wt.%.

[0270] Comparative Example 4:

[0271] The first paste is composed of:

[0272] Propylene glycol 47.82wt.%, polyvinyl pyrrolidone 6.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, disodium hydrogen phosphate 0.12wt.%, PEG-1500 3wt.%, triacetin 2.5wt.%.

[0273] The second paste is composed of:

[0274] Glycerin 48.15wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 22wt.%, galactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinylpyrrolidone 0.8wt.%, stannous fluoride 0.3 wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%.

[0275] Comparative Example 5:

[0276] The first paste is composed of:

[0277] Propylene glycol 47.82wt.%, polyvinyl pyrrolidone 6.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, disodium hydrogen phosphate 0.12wt.%, PEG-1500 3wt.%, triacetin 2.5wt.%.

[0278] The second paste is composed of:

[0279] Glycerin 48.45wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 19wt.% ((silicon dioxide (ordinary friction type) 12 wt.%, silica (high friction type) 7 wt.%)), trichlorogalactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinylpyrrolidone 0.8wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%, sodium carbonate 1.5wt.%, baking soda 1.5wt.%.

[0280] Comparative Example 6:

[0281] The composition of the first paste is:

[0282] Propylene glycol 47.82wt.%, polyvinyl pyrrolidone 1.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) 5wt.%, disodium hydrogen phosphate 0.12wt.%, PEG-1500 3wt.%, triacetin 2.5wt.%.

[0283] The composition of the second paste is:

[0284] Glycerin 48.45wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 19wt.% ((silicon dioxide (ordinary friction type) 12 wt.%, silica (high friction type) 7 wt.%)), trichlorogalactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinylpyrrolidone 0.8wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%, sodium carbonate 1.5wt.%, baking soda 1.5wt.%.

[0285] Comparative Example 7

[0286] The first paste is composed of:

[0287] Propylene glycol 50.32wt.%, polyvinyl pyrrolidone 1.9wt.%, trichlorogalactose 0.16wt.%, sodium methyl cocoyl taurate 2wt.%, flavor 1wt.%, anhydrous calcium pyrophosphate 15wt.%, mannitol 15wt.%, colloidal silica 6.5wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0wt.%) is 5wt.%, disodium hydrogen phosphate is 0.12wt.%, and PEG-1500 is 3wt.%.

[0288] The second paste is composed of:

[0289] Glycerin 51.45wt.%, PEG-400 20wt.%, silica (thickening type) 5.2wt.%, silica (friction type) 19wt.% (silicon dioxide (ordinary friction type) 12wt.%, silica (high friction type) 7 wt.%), trichlorogalactose 0.14wt.%, sodium methyl cocoyl taurate 2wt.%, polyvinylpyrrolidone 0.8wt.%, sodium fluoride 0.31wt.%, flavor 1.1wt.%.

[0290] Test Example 1:

[0291] The whitening effects of the toothpastes of the test examples and the comparative examples were tested. The verification of the whitening effects was based on the group standard "T / COCIA26-2024 Evaluation of the efficacy of oral cleaning and care products for the prevention and decomposition of exogenous tooth stains in vitro" 7.5 Testing method for the efficacy of decomposing exogenous stains.

[0292] 1. Collection of irritating saliva: After cleaning the oral cavity, obtain human irritating saliva; after shaking and evenly mixing, discard the upper foam, centrifuge the saliva and remove the supernatant for later use. It can be prepared and used immediately.

[0293] 2. In a 37°C oven, hydroxyapatite (HAP) sheets were immersed in human irritant saliva for 1.5 h to form acquired biofilm on their surface to simulate the oral environment.

[0294] 3. Preparation of dye solution: Prepare 2.5g / L gastric mucin solution (use deionized water), sterilize at 121℃; then add coffee, black tea, soy sauce, tobacco, etc., sterilize at 115℃ for 10 minutes, cool at room temperature for later use. Filter before use.

[0295] 4. Randomly group the HAP sheets and place the HAP sheets soaked in saliva in staining solution for 16 hours.

[0296] 5. After taking out the stained piece, rinse it with clean water, wipe it dry with absorbent paper, and measure the whiteness value L1 with a colorimeter within 10 minutes. Then weigh 0.5g of sample 1 and sample 2 respectively, add 5g of distilled water into a 50mL plastic centrifuge test tube, and immediately put the stained HAP piece in. After vortexing on a vortex oscillator for 3 minutes (simulating brushing teeth for 3 minutes), rinse it with clean water, wipe it dry with absorbent paper, and finally measure the whiteness value L2 with a colorimeter within 10 minutes.

[0297] The difference in whiteness value of HAP sheets before and after dyeing in each group was calculated as ΔL=L2-L1.

[0298] In order to compare the advancedness of its technical effect, two pieces of dyed hydroxyapatite were tested in parallel to see the change in whiteness after being immediately treated with the slurry prepared with the above-mentioned toothpaste.

[0299] The obtained data are shown in Table 1 below.

[0300] Table 1

[0301]

[0302] It should be noted that the whitening effect is judged to be weak when the ΔL value is ≤3; the whitening effect is judged to be medium when the ΔL value is 3<ΔL value ≤6; and the whitening effect is judged to be strong when the ΔL value is>6.

[0303] The experimental results show that each embodiment exhibits at least a moderate whitening effect, indicating that the solution of the present application can effectively achieve a whitening effect.

[0304] The ΔL value of Example 8 is greater than that of Comparative Examples 3 and 4, indicating that the Fenton-like reaction-promoting whitening effect of Example 8 is stronger than that of Comparative Examples 3 and 4. This is because the abilities and rates of releasing peroxyl radicals, free hydroxyl radicals and active oxygen within 3 minutes are different, and the Fenton-like reaction effect exhibited by Example 8 is the best.

[0305] Further, compared with Example 6, Example 9 has a lower whitening effect than Example 9; it can be seen that the whitening effect of the combination of (hydrogen peroxide + triacetin): (sodium bicarbonate + sodium carbonate) is lower than that of the combination of (hydrogen peroxide + triacetin): stannous fluoride, while Example 1 further improves the whitening effect by combining (hydrogen peroxide + triacetin): (stannous fluoride + sodium bicarbonate + sodium carbonate).

[0306] From the data of Examples 5-7, it can be seen that, when triacetin, stannous chloride, sodium bicarbonate and sodium carbonate remain unchanged, changing the amount of PVP-H2O2 complex added has a greater impact on the experimental whitening effect. Example 6 shows an excellent whitening effect, but the amount of peroxide added is the largest, the formula is not gentle enough, and the irritation to the mucosa increases. If this value is exceeded, it may cause mucosal shedding.

[0307] Test Example 2:

[0308] Superoxide radicals (O2 - ) Determination

[0309] In order to further verify the experimental whitening effect, a spectrophotometer was used to test the superoxide free radicals (O2 - ) production and clearance rates.

[0310] Hydrogen peroxide, under the action of catalysts (such as triacetin, bicarbonate, carbonate and low-valent metal ions, etc.), will produce superoxide free radicals (O2 - ), hydroxyl radical (•OH) and alkyl peroxyl radical (ROO•) are thus determined. 2- The generation and removal rates can indirectly show the catalytic whitening effect of hydrogen peroxide under different conditions.

[0311] 1. Principle

[0312] O2 - Can react with hydroxylamine solution to generate NO2 - :

[0313] NH2OH+2O2 - +H + =NO2 - + H2O2+H2O

[0314] NO2 - The color reaction between p-aminobenzenesulfonic acid and α-naphthylamine generates p-benzenesulfonic acid-azo-α-naphthylamine (red), and the color reaction is as follows:

[0315] HOO2S-C6H4-NH3·CH3COOH+HNO2--HOO2S-C6H4-N2(CH3COO)+H2O

[0316] p-Aminobenzenesulfonic acid nitrite

[0317] HOO2S-C6H4-N2(CH3COO)+C 10 H7NH2--HOO2S-C6H4-N2C 10 H6·NH2+CH3COOH

[0318] α-Naphthylamine Red azo substance

[0319] The red product has a specific absorption peak at 530nm. - The standard curve of the color reaction converts the absorbance at 530nm into NO2 - concentration, and then directly carry out O2 - Stoichiometric, i.e. NO2- Multiply the concentration by 2 to get O2 - concentration.

[0320] 2. Instruments and Equipment

[0321] (1) Spectrophotometer

[0322] (2) Pipette: 1 0.5 mL, 2 1 mL, 4 2 mL

[0323] (3) Test tubes: 1 5 mL tube, several 20 mL tubes

[0324] (4) Constant temperature water bath

[0325] 3. Reagents

[0326] (1) 65 mmol L-1 phosphate buffer, pH 7.8.

[0327] (2) 17 mmol / L-1 p-aminobenzenesulfonic acid: Weigh 2.94 g p-aminobenzenesulfonic acid, dissolve it in 25 mL concentrated HCl, and dilute to 1000 mL with distilled water.

[0328] (3) 7mmol·L-1 α-naphthylamine: Weigh 1.0g of α-naphthylamine, dissolve it in 25mL of glacial acetic acid, and make up to 1000mL with distilled water.

[0329] (4) 10 mmol·L-1 HCl hydroxylamine.

[0330] (5) NaNO2 standard solution: weigh 0.1000g of NaNO2 (AR grade), dilute to 100mL with distilled water, shake well, take 5mL and dilute to 1000mL with distilled water, which is the NO2 content per mL. - 5μg standard solution.

[0331] 4. Methods and Steps

[0332] (1) Preparation of standard curve: Take 7 20 mL test tubes, number them, and add reagents in the order of Table 2. Shake the test tubes to mix each time a reagent is added:

[0333] Table 2

[0334]

[0335] After adding the reagent, place the test tube in a 30℃ water bath for 30 minutes. After the color reaction, measure the absorbance at 530nm. - The concentration is the horizontal axis, and the absorbance value corresponding to 530nm is the vertical axis to draw a standard curve.

[0336] (2) O2 -Extraction: Take 1~2g of the sample to be tested (the supernatant after the reaction of the double-tube toothpaste functional raw materials for three minutes) and add an appropriate amount of 65mmol·L -1 Phosphate buffer (pH 7.8), make up to 1000 mL, and take the supernatant for later use.

[0337] (3) O2 of each group of samples - Determination: Take 3 test tubes, add 2 mL of sample extract (supernatant), 1.5 mL of phosphate buffer, and 0.5 mL of hydroxylamine hydrochloride to each, mix and keep warm in a constant temperature water bath at 25°C for 20 min. Take another 3 test tubes, take 2.0 mL of the reaction solution from each of the above 3 test tubes, add them to the corresponding 3 test tubes, add 2.0 mL of 17 mmol·L-1 p-aminobenzenesulfonic acid and 2.0 mL of 7 mmol·L-1 α-naphthylamine to each, react in a constant temperature water bath at 30°C for 30 min, measure the absorbance of the color developing solution at 530 nm after the reaction (zero adjustment of the standard curve in test tube No. 1), and record the measurement data.

[0338] (4) O2 - Content calculation: Find out the NO2 content of the sample solution from the standard curve. - The concentration of O2 - The concentration (X) of O2 is calculated as follows: - content

[0339]

[0340] Wherein, Vt: volume of sample extract (mL); 2: dilution factor of sample extract during determination; FW: weight of reaction solution after dilution; Vs: amount of sample solution taken during color reaction (mL).

[0341] This method can roughly detect O2 - Approximate content (ug / g).

[0342] The solutions prepared with the functional raw materials in each comparative example or embodiment were mixed at a mass ratio of 1:1; the test was carried out according to the above test method, and the results are shown in Table 3.

[0343] Table 3

[0344]

[0345] From the experimental data in the above table, it can be seen that the O2 released by the embodiment - The content is approximately higher than that of each comparative example (except comparative example 6, which was subsequently verified to have poor anti-sensitivity). This shows that the hydrogen peroxide used in the embodiment has a synergistic effect with triacetin, bicarbonate and low-valent metal ions, and the coordinated reaction of the three can quickly release active oxygen and peroxyl radicals and hydroxyl radicals; thereby achieving the effect of bleaching teeth and improving tooth surface discoloration immediately.

[0346] Test Example 3:

[0347] Anti-allergic effect verification

[0348] 1. Acid etching

[0349] The bovine teeth tested in this study were fresh, and the surface contaminants were removed. After being rinsed, they were placed in deionized water containing 0.05% thymol and placed in a 4°C refrigerator for later use. During the experiment, the preserved fresh bovine teeth were cut into 1 cm × 1 cm × 2 m cubic tooth slices by a low-speed cutter, and then ground with a grinding and polishing machine (600# sandpaper) to remove the bovine tooth enamel and expose the dentinal tubules.

[0350] The two prepared bovine tooth slices (roughly 0.8cm×0.8cm×1mm in size) were etched with 6% citric acid solution for 3 minutes, and then placed in pure water and cleaned in an ultrasonic cleaner for 3 minutes to remove surface substances. After drying at room temperature for 24 hours, the teeth were sent for testing of the permeability of the dentinal tubules. The scanning electron microscopy images of the surface morphology of the bovine teeth were as follows: Figure 1 He Ru Figure 2 shown.

[0351] 2. Testing

[0352] Place the acid-etched bovine tooth piece in the groove of the acrylic plate, take 0.4g of toothpaste of Comparative Example 6 and Example 1 respectively on the tooth piece in the groove of the acrylic plate, and then take 0.8g of water into the groove of the acrylic plate. Place the acrylic plate on an electronic balance, and immediately use an electric toothbrush (oral-B) to simulate brushing for 3 minutes, then let it stand for 2 minutes, and control the balance count to display about 150g. After each brushing, use 20mL of deionized water to oscillate and clean at a frequency of 180rpm in a constant temperature oscillator for 30s, then take out the tooth piece and place it in artificial saliva and store it at 37°C. Brush 8 times a day (place the tooth piece in artificial saliva after each brushing), brush for a total of 3 days, and simulate brushing for 14 days.

[0353] After the toothbrushing experiment, the samples were shaken and cleaned for 2 minutes and then dried. The bovine dentin samples were dried in a 25°C incubator for 24 hours and observed by scanning electron microscopy (SEM) after drying.

[0354] Figure 7 and Figure 8 The difference in the surface morphology of bovine teeth under 1k times electron microscope after the plugging experiment in Comparative Example 6 and Example 1 is shown in the scanning electron microscope image of the surface morphology of bovine teeth obtained in Comparative Example 6. Figure 7 As shown in the figure, the corresponding scanning electron microscope image of the bovine tooth surface morphology before the test experiment is as follows Figure 5 The surface morphology of the bovine tooth obtained in Example 1 is shown in the scanning electron microscope image. Figure 8As shown in the figure, the corresponding scanning electron microscope image of the bovine tooth surface morphology before the test experiment is as follows Figure 6 .

[0355] Under the same experimental conditions, they all played a certain role in blocking dentinal tubules. Figure 7 It can be seen that the dentinal tubules are completely open. This is because there are no special mineralization blocking ingredients, and there are almost no completely blocked dentinal pores. All of them are open pores, with only a few superficial blocking materials retained by the action of hydrated silica. Figure 8 It can be seen that its overall blocking effect is better than Figure 7 Due to the combined effect of tin ions and carbonate ions produced by the Fenton-like reaction, a deposited sealant is formed in the dentin pores, which reduces tooth sensitivity.

[0356] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A whitening toothpaste, characterized in that: include: An extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are each contained in one of the sub-chambers; the first paste comprises: peroxide, carboxylic acid esters, and a first carrier acceptable to toothpaste; the second paste comprises: alkaline salts, low-valent metal salts, and a second carrier acceptable to toothpaste; the peroxide can undergo a Fenton-like reaction after contacting the low-valent metal salt; the carboxylic acid esters comprise: at least one of triacetin, ethyl acetate, propyl acetate, or amyl acetate.

2. The whitening toothpaste according to claim 1, characterized in that The low-valent metal salt includes at least one of stannous salt, cuprous salt or ferrous salt.

3. The whitening toothpaste according to claim 2, characterized in that The stannous salt includes at least one of stannous chloride and stannous fluoride.

4. The whitening toothpaste according to claim 2, characterized in that: The cuprous salt includes at least one of cuprous chloride or cuprous fluoride.

5. The whitening toothpaste according to claim 2, characterized in that: The ferrous salt includes at least one of ferrous chloride, ferrous fluoride and ferrous gluconate.

6. The whitening toothpaste according to claim 1, characterized in that: The peroxide includes at least one of hydrogen peroxide or a complex of hydrogen peroxide.

7. The whitening toothpaste according to claim 6, characterized in that The hydrogen peroxide complex comprises at least one of a polyvinyl pyrrolidone-hydrogen peroxide complex and urea peroxide.

8. The whitening toothpaste according to claim 1, characterized in that: In terms of mass percentage, in the first paste, the added amount of the peroxide is 2% to 18%; and the content of hydrogen peroxide in the peroxide is less than 4%.

9. The whitening toothpaste according to claim 1, characterized in that: In terms of mass percentage, the amount of the low-valent metal salt added to the second paste is 0.01% to 0.62%.

10. The whitening toothpaste according to claim 1, characterized in that: The alkaline salts include at least one of carbonates and bicarbonates.

11. The whitening toothpaste according to claim 10, characterized in that: The carbonate includes at least one of sodium carbonate or potassium carbonate; the bicarbonate includes at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.

12. The whitening toothpaste according to claim 10, characterized in that The second paste includes the carbonate and the bicarbonate; in the second paste, the carbonate is added in an amount of 0.1% to 3.0% by mass; the bicarbonate is added in an amount of 0.5% to 5% by mass; or The second paste includes the carbonate; in terms of mass percentage, the amount of the carbonate added to the second paste is 0.1% to 8.0%; or The second paste includes the bicarbonate; in the second paste, the amount of the bicarbonate added is 0.5% to 8.0% by mass.

13. The whitening toothpaste according to claim 1, characterized in that: The first carrier includes: abrasive, emulsifier, moisturizer, thickener and acid-base regulator.

14. The whitening toothpaste according to claim 13, characterized in that The friction agent includes at least one of calcium pyrophosphate and friction-type silica.

15. The whitening toothpaste according to claim 13, characterized in that The emulsifier includes at least one of sodium methyl cocoyl taurate, alkyl glucoside, sodium lauryl sarcosinate or sodium lauryl sulfate.

16. The whitening toothpaste according to claim 13, characterized in that The moisturizing agent includes at least one of propylene glycol, polyethylene glycols or glycerin.

17. The whitening toothpaste according to claim 13, characterized in that The thickener comprises at least one of thickening silicon dioxide and polyvinyl pyrrolidone.

18. The whitening toothpaste according to claim 13, characterized in that: The acid-base regulator includes: disodium hydrogen phosphate.

19. The whitening toothpaste according to claim 13, characterized in that: In terms of mass percentage, the first paste comprises: 2% to 18% of the peroxide; 1.0% to 3.0% of carboxylic acid esters; 10% to 20% of abrasives, 1.5% to 2.5% of emulsifiers, 41% to 60% of moisturizers, 2.1% to 18% of thickeners; and 0.1% to 1.0% of acid-base regulators.

20. The whitening toothpaste according to claim 1, characterized in that The second carrier includes: a moisturizer, a thickener, an abrasive, an emulsifier, and an anti-caries agent.

21. The whitening toothpaste according to claim 20, characterized in that The moisturizing agent includes at least one of glycerin, polyethylene glycols or propylene glycol.

22. The whitening toothpaste according to claim 20, characterized in that The thickener comprises at least one of thickening silicon dioxide and polyvinyl pyrrolidone.

23. The whitening toothpaste according to claim 20, characterized in that The friction agent includes at least one of friction-type silica or calcium pyrophosphate.

24. The whitening toothpaste according to claim 20, characterized in that The emulsifier includes at least one of sodium methyl cocoyl taurate, alkyl glucoside, sodium lauryl sarcosinate or sodium lauryl sulfate.

25. The whitening toothpaste according to claim 20, characterized in that The anti-caries agent includes: sodium fluoride.

26. The whitening toothpaste according to claim 20, characterized in that In terms of mass percentage, the second paste comprises: 0.01% to 0.62% of the low-valent metal salt; 0.1% to 8.0% of alkaline salts; 67% to 80% of moisturizers, 2.1% to 10% of thickeners, 10% to 20% of abrasives, 1.5% to 2.5% of emulsifiers; and 0.1% to 0.32% of anticaries agents.

27. The whitening toothpaste according to any one of claims 1 to 26, characterized in that The extrusion container also includes: a cover plate, a transmission extrusion structure and a partition plate; The partition is disposed in the chamber, and is used to divide the chamber into at least two sub-chambers along the extension direction of the container body, and the sub-chambers are communicated with the outlet of the container body; The cover plate is detachably connected to the tail of the container body through a connecting structure for sealing; The transmission extrusion structure is disposed in the container body and is movably connected to the cover plate. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber from the outlet.

28. The whitening toothpaste according to claim 27, characterized in that The transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is transmission-connected to the transmission member, and the transmission member drives the piston to move forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

29. The whitening toothpaste according to claim 27, characterized in that The whitening toothpaste comprises: a base; The base comprises: a base body; A driving component is disposed in the base body; A transmission structure is arranged in the base body and connected to the driving component; a docking component is arranged on the transmission structure, and the docking component is used to be fixedly connected with the transmission extrusion structure in the extrusion container when the base and the extrusion container are assembled; the driving component drives the transmission structure, and then drives the transmission extrusion structure fixedly connected to the docking component to realize the extrusion of the first paste and the second paste; A control module is disposed in the base body and is electrically connected to the driving component; The power supply module is arranged in the base body and is electrically connected to the control module and the driving component respectively.

30. The whitening toothpaste according to claim 29, characterized in that The transmission structure includes: a bracket and a transmission member; the transmission member is arranged on the bracket, the output end of the driving member passes through the bracket, and the output end of the driving member is connected to the transmission member, and the docking member is arranged on one end of the transmission member away from the output end of the driving member.

31. A method for preparing a whitening toothpaste, characterized in that: The whitening toothpaste comprises: Extruding a container, a first paste, and a second paste; The extrusion container comprises: a container body; at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are respectively contained in one of the sub-chambers; the first paste comprises: peroxide, carboxylic acid esters and a first carrier acceptable to toothpaste; the second paste comprises: alkaline salts, low-valent metal salts and a second carrier acceptable to toothpaste; the peroxide can undergo a Fenton-like reaction after contacting the low-valent metal salt; the carboxylic acid esters comprise: at least one of triacetin, ethyl acetate, propyl acetate or amyl acetate; The preparation method comprises: The first paste is injected into one of the sub-chambers; and the second paste is injected into another of the sub-chambers.

32. The method for preparing a whitening toothpaste according to claim 31, characterized in that: The low-valent metal salt includes at least one of stannous salt, cuprous salt or ferrous salt.

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