Traditional Chinese medicine composition for treating herpes zoster and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating herpes zoster. The traditional Chinese medicine composition comprises 3-6 parts of cowherb seed, 1-2 parts of borneol and 3-20 parts of semen cuscutae. Optionally, the traditional Chinese medicine further comprises 3-9 parts of fructus cnidii, 2-6 parts of lumbricus and 3-4 parts of snake slough. The traditional Chinese medicine composition has a very obvious effect on treating herpes zoster and postherpetic neuralgia, and is high in cure rate and low in recurrence rate.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating herpes and a preparation method thereof. Background Art

[0002] Herpes zoster is a common dermatological disease caused by the reactivation of varicella-zoster virus (VZV). It can be transmitted through droplets and contact. The primary infection mainly causes chickenpox. In addition to skin damage, it is often accompanied by neuropathic pain. It is common in the elderly, immunosuppressed or immunodeficient population, and seriously affects the quality of life of patients.

[0003] Chinese patent CN201610413587.8 discloses a traditional Chinese medicine composition for treating postherpetic neuralgia, which is made of 19 raw materials, including 15-20 grams of gentian, 10-15 grams of Uncaria rhynchophylla, 8-12 grams of ligusticum chuanxiong, 10-12 grams of curcuma, 10-15 grams of moutan bark, 6-10 grams of peony root, 20-25 grams of dragon claw leaf, 6-8 grams of ajuga, 10-12 grams of earthworm, 12-15 grams of fenugreek, 15-20 grams of plantain seed, 8-10 grams of schizonepeta tenuifolia, 12-16 grams of bupleurum, 6-10 grams of Macleanium, 15-20 grams of unicorn herb, 16-18 grams of seven-leaf flos, 3-5 grams of trichosanthes, 12-16 grams of augustia, and 3-5 grams of smilax china.

[0004] CN201510838944.0 discloses a preparation for treating herpes zoster, which is made of the following raw materials in the following weight ratio: 5-15 parts of Platycladus orientalis leaves, 1-5 parts of Poria cocos, 2-6 parts of Portulaca oleracea, 3-8 parts of Millettia spatholobi, 2-6 parts of Vaccaria segetalis, 3-8 parts of Lithospermum officinale, 5-15 parts of Luffa fructus, 1-5 parts of Verbena officinalis, 5-15 parts of Pulsatilla scabra, 2-6 parts of Gleditsia sinensis thorns, 3-8 parts of Zedoariae rhizome, 1-5 parts of Lycopodiella cuneata, 1-5 parts of Xuanming powder, 2-6 parts of Lycopodiella cuneata, 5-15 parts of Citrus aurantium, 3-8 parts of Hedyotis diffusa, 1-5 parts of Trichosanthes kirilowii, 5-15 parts of Paeonia suffruticosa, 3-8 parts of Buckwheat, 2-6 parts of Trachelospermum jasminoides, 2-6 parts of Bambusa officinalis, 3-8 parts of Campsis creeper, and 5-15 parts of Imperata cylindrica.

[0005] However, the Chinese medicine formula for treating herpes zoster disclosed in the above prior art has complex ingredients and is not effective. In the field of Western medicine, currently approved systemic antiviral drugs, including acyclovir, valacyclovir, famciclovir, methylcobalamin, etc., are drugs for treating herpes simplex, but they are not effective for herpes zoster, and postherpetic neuralgia is easily formed after recovery.

[0006] Therefore, there is still a lack of a Chinese medicine composition and preparation with good therapeutic effect for treating herpes zoster. Summary of the invention

[0007] All references mentioned herein are incorporated herein by reference. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs. Unless otherwise specified, the techniques used or mentioned herein are standard techniques known to one of ordinary skill in the art. Materials, methods, and examples are for illustrative purposes only and are not intended to be limiting.

[0008] In order to solve the problems existing in the above-mentioned prior art, the present invention provides a Chinese medicine composition, preparation and preparation method and application thereof for effectively treating herpes zoster.

[0009] The traditional Chinese medicine composition for treating herpes zoster comprises fenugreek, borneol and dodder seed.

[0010] In a preferred embodiment of the present invention, the Chinese medicine composition for treating herpes zoster comprises the following raw materials in parts by weight: 3-6 parts of Vaccaria segetalis, 1-3 parts of Borneol, and 3-20 parts of Cuscuta australis.

[0011] Optionally, in order to better treat postherpetic neuralgia, the composition of the present invention further comprises 3-9 parts of Cnidium monnieri and 3-4 parts of snake skin.

[0012] Optionally, in order to better dredge meridians, promote blood circulation and relieve pain, the composition of the present invention further comprises 2-6 parts of earthworms.

[0013] Optionally, the Chinese medicine composition for treating herpes zoster is prepared from the following Chinese medicines, calculated by weight: 6 parts of Vaccaria segetalis, 3 parts of Cnidium monnieri, 1.5 parts of Borneol, 20 parts of Cuscuta australis, 2 parts of Pheretima, and 3 parts of Snake skin.

[0014] The Chinese medicine composition with the above ratio has a therapeutic effective ratio of up to 77%-97.5%, and has outstanding and unexpected technical effects in the treatment of herpes zoster and postherpetic neuralgia.

[0015] Optionally, the Chinese medicine composition is an external preparation, including ointment, cream, spray, etc.

[0016] Optionally, the present invention also provides a method for preparing a Chinese medicine composition for treating herpes zoster, comprising the following steps:

[0017] 1) Put fenugreek, cnidium monnieri, dodder seed, earthworm and snake skin into the pot according to the proportion, heat and stir-fry, simmer the pot over low heat until slightly yellow, then remove from the pot and let it dry.

[0018] 2) After the above Chinese medicine is fried until yellow and dried, borneol is added and crushed into powder using an electric crusher.

[0019] 3) The above powder is sieved through a 100-300 mesh sieve to obtain Chinese medicine powder.

[0020] 4) Add appropriate amount of Vaseline paste to the Chinese medicine powder, stir evenly to make a Chinese medicine paste ointment.

[0021] Optionally, the prepared Chinese medicinal ointment is strictly operated, packaged into bottles, and sealed for storage.

[0022] The present invention also provides an application of the traditional Chinese medicine composition in preparing a medicine for treating herpes zoster and an application of the traditional Chinese medicine composition in preparing a medicine for treating postherpetic neuralgia.

[0023] The common pharmacological effects of the Chinese medicinal raw materials selected by the present invention in this field are as follows:

[0024] Vaccaria is the dried mature seeds of Gypsophila vaccaria (L.) Sm., a plant of the Caryophyllaceae family. It is sweet, bitter and mild in nature, slightly toxic, and enters the liver meridian. It has the effects of promoting blood circulation and dispersing blood stasis, reducing swelling and relieving pain, and dredge meridians and collaterals. It is used for meridian obstruction, carbuncle, blister, congestion caused by trauma, and milk obstruction.

[0025] Cnidium monnieri (L.) Cuss., also known as wild carrot seed, is the dried mature fruit of the Apiaceae plant Cnidium monnieri. It has a bitter and warm taste and is slightly toxic. It can kill insects, dry dampness and strengthen yang. It is used for stubborn ringworm, scabies, scrotal eczema. It has the effect of external use to treat skin diseases. It can also be used for impotence, female vaginal itching, etc.

[0026] Cuscuta austral is R.Br. or Cuscutachinensis Lam., a plant of the Convolvulaceae family, is a dried mature seed. Nature and flavor: pungent, sweet and neutral, it enters the kidney meridian, nourishes the liver and kidney, strengthens yang and stops diarrhea. It is used for impotence, spermatorrhea, diarrhea, and soreness of the waist and knees.

[0027] Earthworm: The dried whole body of the genus Pheretima; Nature and flavor: salty and cold, clears away heat and stops spasms, calms the nerves and asthma, dredges the meridians, lowers blood pressure, detoxifies, and is a diuretic. It is used for fever, convulsions, bronchial asthma, hemiplegia after a stroke, rheumatic pain, and urinary obstruction.

[0028] Snake skin: salty and cold in nature, clears away heat and detoxifies, cools blood and relieves pain. Used for: redness, swelling, heat and pain in sores, skin ulcers, and boils.

[0029] Borneol: bitter and bitter in nature and flavor, slightly cold, aromatic and invigorating, dissipating stagnation of fire, clearing away heat and relieving pain. Used for: coma, convulsions, various sores, itching, scabies, throat diseases and eye diseases. DETAILED DESCRIPTION

[0030] The present invention will be further described below in conjunction with specific embodiments, and the advantages and features of the present invention will become clearer as the description proceeds. However, these embodiments are exemplary only and do not constitute any limitation to the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.

[0031] The clinic where the inventor works is well-known for treating various herpes-related diseases. In practice, the inventor found that Chinese medicines such as Vaccaria segetalis, Cnidium monnieri, and Cuscuta australis have unexpected effects in treating herpes zoster. In order to further optimize the best formula, the inventor designed the following example formulas to compare the therapeutic effects.

[0032] Example 1.

[0033] The present embodiment provides a traditional Chinese medicine composition for treating herpes zoster, the composition comprising raw materials: 30g of Vaccaria segetalis, 90g of Cnidium monnieri, 20g of Borneolum, 30g of Cuscuta australis, 30g of Pheretima, and 30g of Snake skin.

[0034] The above-mentioned Chinese medicine composition is prepared into an ointment according to the following steps:

[0035] (1) Add fenugreek, cnidium monnieri, dodder seed, earthworm, and snake skin into a pot according to the amount, heat and stir-fry, simmer over low heat until slightly yellow, then remove from the pot and let dry;

[0036] (2) After the above Chinese medicine is fried until yellow and dried, borneol is added and the mixture is crushed into powder using an electric crusher;

[0037] (3) passing the above powder through a 100-300 mesh sieve, and then screening to prepare Chinese medicine powder;

[0038] (4) Add an appropriate amount of Vaseline paste to the above-mentioned Chinese medicine powder and stir evenly to make a paste-like ointment.

[0039] Example 2.

[0040] This embodiment provides a traditional Chinese medicine composition for treating herpes zoster, which includes 50g of fenugreek, 60g of cnidium monnieri, 10g of borneol, 60g of dodder seed, 40g of earthworm, and 40g of snake skin. The preparation steps are the same as those in Example 1.

[0041] Example 3.

[0042] This embodiment provides a traditional Chinese medicine composition for treating herpes zoster, which comprises: 60g of Vaccaria segetalis, 60g of Cnidium monnieri, 10g of Borneol, 60g of Cuscuta australis, 60g of Pheretima, and 40g of Snake skin. The steps for preparing the ointment are the same as those in Example 1.

[0043] Example 4.

[0044] This embodiment provides a Chinese medicine composition for treating herpes zoster, which includes: 60g of Vaccaria segetalis, 30g of Cnidium monnieri, 15g of Borneol, 200g of Cuscuta australis, 20g of Pheretima, and 30g of Snake skin. The steps for making the ointment are the same as those in Example 1.

[0045] Comparative Example 1 (without Cuscuta australis)

[0046] Weigh 50g of Vaccaria segetalis, 60g of Cnidium monnieri, 10g of Borneolum, 40g of Pheretima, and 40g of Snake skin. The steps for making the ointment are the same as those in Example 1.

[0047] Comparative Example 2 (excluding Vaccaria segetalis)

[0048] Weigh 60g of Cnidium monnieri, 10g of Borneolum, 70g of Cuscuta chinensis, 40g of Pheretima, and 40g of Snake skin. The steps for making the ointment are the same as those in Example 1.

[0049] Comparative Example 3 (excluding Cnidium monnieri and snake exuviae)

[0050] Weigh 50g of Vaccaria segetalis, 10g of Borneolum, 70g of Cuscuta australis, and 40g of Pheretima. The steps for making the ointment are the same as those in Example 1.

[0051] Analysis of the therapeutic effects of Chinese medicine compositions of different formulas on herpes zoster:

[0052] In the process of exploring the experimental effects of different formulas, the inventor used different comparative examples and prescriptions in the embodiments to treat patients. The therapeutic effect of the Chinese medicine composition of the present invention was analyzed on 280 herpes zoster patients treated in the clinic, and the changes in the condition of each group of patients after 7 days of continuous treatment with different embodiment prescriptions were compared. The results after statistical analysis are shown in Table 1 below, where cure means that the herpes scabs fall off and the pain is completely relieved; marked effect means that the herpes scabs are more than 30% dry and the pain is significantly relieved; ineffective means that the herpes scabs are less than 30% dry and the pain is not significantly relieved.

[0053] Table 1

[0054]

[0055]

[0056] The inventors found in practice that after the herpes zoster is cured, most patients show symptoms of postherpetic neuralgia due to skin damage. After statistical analysis, the statistical analysis of the treatment results of postherpetic neuralgia in patients with herpes zoster after treatment with the above-mentioned scheme of the present invention is shown in Table 2. Wherein cure means that there is no postherpetic neuralgia or itching symptoms at the site of herpes onset.

[0057] Table 2

[0058] Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Number of patients 40 40 40 40 40 40 40 Number of people cured 18 24 23 27 0 13 17

[0059] It can be seen from the above experimental results that the Chinese medicine compositions of the present invention are simple to prepare. By making them into external ointments and applying them to the affected area, they have a very high cure rate for the symptoms of herpes zoster and are effective quickly. Among them, Example 4 has the best effect, with an effective rate of 97.5% in treating herpes zoster, and can effectively inhibit postherpetic neuralgia.

[0060] Typical case treatment process

[0061] The inventor used the Chinese medicine composition of Example 4 of the present invention to clinically treat and observe hundreds of patients with herpes zoster from 2017 to 2024. The treatment process of a typical case is as follows:

[0062] Case 1:

[0063] Mr. Xu, male, 50 years old, from Huaiyang District, Zhoukou City. He came to our clinic on April 22, 2017 for treatment of herpes zoster in the chest, waist and ribs. The affected area had burning pain, and there were dense small blisters in a band-like distribution. He had no fever, headache or general discomfort. The treatment process is as follows:

[0064] 1) First, let the patient sit on a bench and take off his outer clothes to fully expose the affected herpes area. Use iodine to disinfect the herpes area strictly, and use a sterile syringe needle or a sterile three-edged needle to puncture all the blisters in the herpes area. Let the liquid in the blisters flow out completely, and then disinfect and dry again.

[0065] 2) The inventor prepared the formula in Example 4 into a Chinese medicine ointment, applied it to the patient, bandaged it, and asked the patient to come for another dressing change to observe its efficacy.

[0066] 3) When the patient came to change the dressing for the third time, his mental state improved, the pain in the blister area was relieved, and the symptoms were significantly alleviated. The dressing was changed once a day, and the above ointment was applied for about 7-10 consecutive days. The patient was basically cured. After a period of recovery, the patient was completely cured.

[0067] Case 2:

[0068] Mr. Feng, male, 39 years old, from Huaiyang District, Zhoukou City. On November 30, 2017, he came to the inventor's clinic after being introduced by others. He was diagnosed with herpes zoster in the waist, back and ribs. There were no blisters, the pain was not very severe, no headache, no fever. No systemic symptoms. The treatment process is as follows:

[0069] 1) First, let the patient sit on a bench and take off his outer clothes to fully expose the affected area. Use iodine to thoroughly disinfect the affected area. Use a sterile syringe needle or a three-edged needle to puncture all the blisters in the affected area, so that the liquid in the blisters flows out completely, then wipe it dry and disinfect the skin again.

[0070] 2) The Chinese medicine ointment prepared in Example 4 of the present invention is evenly applied to the site of herpes zoster.

[0071] 3) After applying the Chinese medicine ointment, cover it with a sterile dressing and secure it with tape to prevent the herpes site from being contaminated, the sterile dressing and the ointment from falling off, so that the patient will not be affected in life, work, rest and exercise.

[0072] 4) Change the medicine once a day. After 7-8 days of application, the wound will be basically cured.

[0073] Case 3:

[0074] Ms. Jia, 72 years old, from Huaiyang District, Zhoukou City, came to our clinic on June 17, 2024 and was diagnosed with herpes zoster on the back, waist, ribs and abdomen. Many blisters appeared in the herpes area. The herpes was distributed in a band-like manner and was locally red. The patient reported severe pain, like a needle prick or burning pain, headache, and fever caused systemic symptoms. Due to the patient's physical weakness and general fatigue, she did not want to eat and was mentally depressed. The condition was very serious. Subsequently, according to the needs of the condition, the patient was given an infusion to replenish electrolytes in the body, as well as antiviral and anti-infection methods. After the infusion was completed, the next step of external application treatment was implemented. The treatment process is as follows:

[0075] 1) First, let the patient lie on the bed sideways with the correct posture, fully showing the affected area of ​​herpes. Use disinfectant iodine, 75% alcohol, etc. to strictly disinfect the affected area of ​​herpes. Use the needle of a sterile syringe or a three-split needle to puncture all the blisters in the herpes area, let the liquid in the blisters flow out completely, and wipe them dry.

[0076] 2) Use the Chinese medicine ointment of Example 4 of the present invention to evenly apply it to the herpes site. Then use the prepared sterile dressing to cover the ointment and fix it with adhesive tape.

[0077] 3) After seven days of continuous external application, all the scabs on the rash site fell off, and there was a small amount of melanin deposition (no treatment is required, and it will gradually recover later). The patient was followed up and had no sequelae of neuralgia, and his body recovered well.

[0078] Case 4:

[0079] Mr. Li, male, 66 years old, from Huaiyang District, Zhoukou City, retired teacher. He came to our clinic for treatment on August 10, 2019. Before coming to our clinic, this patient had been treated in other clinics. He suffered from herpes zoster in the waist, back, ribs, and chest. The treatment in other clinics had little effect. The herpes continued to develop and spread, and became more and more serious. The herpes area was large, there were many blisters, and it was very serious. The patient was in great pain, couldn't eat, couldn't sleep, had burning pain, and couldn't sit or lie down. The treatment process is as follows:

[0080] 1) First, let the patient sit on a bench and take off his outer clothes to fully expose the affected area. Use iodine or 75% alcohol to perform local strict disinfection. Use a sterile syringe needle or a three-edged needle to puncture all the blisters in the affected area, let the liquid in the blisters flow out completely, then wipe it clean and disinfect it again.

[0081] 2) The Chinese medicine ointment of Example 4 prepared by the present invention is evenly applied on the rashes.

[0082] 3) After applying the ointment, cover it with a sterile dressing and then secure it with tape to prevent it from falling off.

[0083] 4) Apply the ointment once a day for three times in a row. The herpes area will begin to scab. After 7 applications, the scab will basically fall off completely.

[0084] Case 5:

[0085] Mr. Zhang, male, 30 years old, from Huaiyang District, Zhoukou City. He came to our clinic for treatment on June 26, 2021. After asking, we learned that this patient had been treated in the dermatology department of a large hospital in Zhengzhou before coming to our clinic. The expert diagnosed him with herpes zoster on the head, face, and eyes. After a few days of hospitalization, his condition became more and more serious, so he returned to his hometown for treatment in our clinic. At that time, blisters had appeared on the right side of the patient's face, and his eyes could not be opened. The infection was quite serious and the pain was severe, causing systemic symptoms, fever, fatigue, loss of appetite, mental depression, and fatigue. The treatment process is as follows:

[0086] 1) First, let the patient sit on a bench and disinfect the head, face and the area around the eyes. Use a sterile syringe needle to puncture all the blisters on the face to let the liquid in the blisters flow out, wipe dry, and disinfect again.

[0087] 2) The Chinese medicine ointment of Example 4 prepared by the present invention is evenly applied to the part with herpes. A prepared sterile dressing is applied on the top of the ointment, and the sterile dressing is fixed with a medical net on the head to prevent the ointment from falling off.

[0088] 3) After changing the dressing three times, the herpes scabs formed, and after changing the dressing for 7 days, the herpes scabs completely fell off until the patient was cured. After a period of time, the patient was followed up and no symptoms of postherpetic neuralgia or other adverse reactions were found. The head, face, and eyes returned to normal.

Claims

1. A Chinese medicine composition for treating herpes zoster, characterized in that: The Chinese medicine composition comprises, by weight, 3-6 parts of fenugreek, 1-2 parts of borneol, and 3-20 parts of dodder seeds.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition further comprises, by weight, 3-9 parts of Cnidium monnieri, 2-6 parts of Pheretima, and 3-4 parts of snake skin.

3. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition is calculated by weight and includes: 6 parts of fenugreek, 3 parts of cnidium monnieri, 1.5 parts of borneol, 20 parts of dodder seeds, 2 parts of earthworms, and 3 parts of snake skin.

4. The Chinese medicine composition according to any one of claims 1 to 3, wherein the Chinese medicine composition is an external preparation.

5. The Chinese medicine composition according to claim 4, wherein the external preparation comprises an ointment, a cream or a spray.

6. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a drug for treating herpes zoster or postherpetic neuralgia.

7. A method for preparing a Chinese medicine composition for treating herpes zoster, characterized in that: The preparation method comprises the following steps: 1) Put the Chinese medicine composition according to any one of claims 1 to 3 into a pot according to the proportion of fenugreek, cnidium monnieri, dodder seed, earthworm and snake skin, heat and stir-fry, simmer the pot over low heat until slightly yellow, then remove from the pot and cool and dry. 2) After the above Chinese medicine is fried until yellow and dried, borneol is added and crushed into powder using an electric crusher. 3) The above powder is sieved through a 100-300 mesh sieve to obtain Chinese medicine powder. 4) Add appropriate amount of Vaseline paste to the Chinese medicine powder, stir evenly to make a Chinese medicine paste ointment.

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