Traditional Chinese medicine formula for treating herpes zoster sequelae

Abstract

The invention discloses a traditional Chinese medicine formula for treating herpes zoster sequelae, and belongs to the technical field of traditional Chinese medicine formulas for herpes zoster, the traditional Chinese medicine formula comprises the following raw materials by weight: 47-52 parts of phellodendron, 47-52 parts of rheum officinale, 47-52 parts of goldthread root, 47-52 parts of white spirit, 47-52 parts of galactophyllite, 47-52 parts of talc, 47-52 parts of pseudosciaena crocea, 3-8 parts of borneol, 47-52 parts of gypsum rubrum, and 3-8 parts of mirabilite. According to the traditional Chinese medicine composition, the cortex phellodendri, the radix et rhizoma rhei, the rhizoma coptidis, the alumen, the galactophyllite, the talc, the pseudosciaena crocea, the gypsum rubrum and the like which are used for clearing away heat and toxic materials, eliminating dampness and healing sores are used as main materials, and the borneol and the mirabilite are used as auxiliary materials for enhancing the effects of relieving swelling and pain and transdermal absorption; the traditional Chinese medicine composition is especially suitable for symptoms such as postherpetic neuralgia and skin scorching hot stabbing pain, and is high in pertinence and remarkable in curative effect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine formula technology for treating shingles, specifically a traditional Chinese medicine formula for treating sequelae of shingles. Background Technology

[0002] Herpes zoster, also known as shingles in modern medicine, is an acute infectious skin disease caused by the reactivation of the varicella-zoster virus (VZV). It is more common in middle-aged and elderly people or those with weakened immune systems. The typical manifestation is clustered blisters along the nerve distribution area, accompanied by severe burning or stinging pain. Although the rash gradually subsides after antiviral treatment in most patients, about 10%–30% of patients will develop postherpetic neuralgia (PHN), which is more common in people over 60 years of age.

[0003] Currently, Western medicine treatment for shingles mainly includes antidepressants, antiepileptic drugs, opioid analgesics, and local anesthetics. However, these treatments have problems such as slow onset of action, numerous side effects, and strong dependence with long-term use. They are also difficult to effectively relieve symptoms such as burning, stinging, and nerve sensitization. Traditional Chinese medicine has accumulated rich experience in treating shingles and its sequelae, often using methods such as clearing heat and detoxifying, promoting blood circulation and unblocking collaterals, and drying dampness and astringing sores. External Chinese medicine preparations are increasingly valued in clinical practice due to their advantages of directly reaching the lesion, rapid transdermal absorption, and high safety.

[0004] However, existing external Chinese medicine formulas generally have the following shortcomings: First, the formulation is not targeted enough and fails to meet the multiple needs of clearing heat, relieving pain, and promoting tissue regeneration and wound healing; second, the mineral-based medicinal materials are not processed in a standardized manner, which affects the purity and fineness of the medicine and reduces the transdermal efficiency; third, the preparation process is crude, the mixing is uneven, the stability of the effective ingredients is poor, resulting in unstable efficacy. Therefore, there is an urgent need to develop a new type of external Chinese medicine formula that is scientifically formulated, technologically advanced, has a definite curative effect, and is suitable for postherpetic neuralgia and burning pain symptoms of the skin. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine formula for treating sequelae of shingles, so as to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a traditional Chinese medicine formula for treating sequelae of shingles, comprising the following raw materials in parts by weight: 47-52 parts of Phellodendron bark, 47-52 parts of rhubarb, 47-52 parts of Coptis chinensis, 47-52 parts of white powder, 47-52 parts of calamine, 47-52 parts of talc, 47-52 parts of otolith, 3-8 parts of borneol, 47-52 parts of gypsum, and 3-8 parts of mirabilite;

[0007] As a further preferred embodiment of this technical solution, the following raw materials are included in parts by weight: 50 parts of Phellodendron bark, 50 parts of rhubarb, 50 parts of Coptis chinensis, 50 parts of white powder, 50 parts of calamine, 50 parts of talc, 50 parts of otolith, 5 parts of borneol, 50 parts of gypsum, and 5 parts of mirabilite.

[0008] As a further preferred embodiment of this technical solution, the following steps are included:

[0009] S1: Clean the Phellodendron bark, rhubarb, Coptis chinensis, and white peony root, removing impurities and non-medicinal parts, and wash them thoroughly. At the same time, remove mud and sand impurities from calamine, talc, otolith, and gypsum, wash and dry them. Also, store borneol and Glauber's salt separately in a cool, dry place to avoid moisture and volatilization.

[0010] S2: Chop or coarsely grind the Phellodendron bark, rhubarb, Coptis chinensis, and white powder. Calcinate or water-levigate the mineral medicines such as calamine, talc, otolith, and calcite to improve purity and fineness. Grind borneol and calcined ...

[0011] S3: The mixed coarse powder is pulverized to a fineness of 120 mesh or higher by an ultra-fine pulverizing device to improve the transdermal absorption rate of the drug and to fully mix the ultra-fine pulverized drug powder.

[0012] S4: Using the equal-increment method, add the fine borneol powder to the mixed powder in batches, and operate in a sealed manner to prevent volatilization. Add the fine Glauber's salt powder to the above mixture. At the same time, sieve and mix repeatedly 3-4 times to ensure that each component is evenly distributed.

[0013] S5: Conduct tests for appearance, particle size, moisture content, microbial limits, and content determination;

[0014] S6: After passing inspection, the contents shall be packaged into light-proof, sealed containers according to specifications, and the net content of each bag / bottle shall meet the standard.

[0015] S7: The quality authorized person reviews all production and inspection records and issues a release order after confirming that they meet the standards;

[0016] As a further preferred embodiment of this technical solution: the calcination temperature in S2 is 400-600℃, the calcination time is 1-2 hours, the amount of water added during water levigation is 3-5 times the weight of the powder, after stirring and settling, the upper suspension is taken, and after precipitation and drying, an extremely fine powder is obtained.

[0017] As a further preferred embodiment of this technical solution: the ultrafine pulverization in S3 is carried out by air jet milling or vibration milling, the pulverization temperature is -10℃ to 10℃, the particle size of the pulverized medicine powder is D90≤15μm, and the specific surface area is ≥1.5m² / g;

[0018] As a further preferred embodiment of this technical solution, the specific operation steps of the equal incremental method in S4 are as follows:

[0019] S41: Place the borneol powder and an equal amount of mixed medicine powder in a mixer and mix for 5-10 minutes;

[0020] S42: Add an equal amount of mixed powder to the mixture and continue mixing for 5-10 minutes;

[0021] S43: Repeat the above steps until all the borneol has been added;

[0022] S44: Add the fine powder of Glauber's salt in 2-3 batches, mixing for 5-10 minutes each time. Finally, pass it through a 120-mesh sieve 3-4 times. The total mixing time should not be less than 30 minutes. The relative humidity of the mixing environment should be controlled below 45%.

[0023] Compared with the prior art, the beneficial effects of the present invention are:

[0024] 1. In this invention, the main ingredients are heat-clearing, detoxifying, and dampness-drying herbs such as Phellodendron bark, rhubarb, Coptis chinensis, alum, calamine, talc, fish brain stone, and gypsum, which are used to clear heat, detoxify, dry dampness, and astringe sores. Borneol and Glauber's salt are added to enhance the effects of reducing swelling, relieving pain, and promoting transdermal absorption. The synergistic effect of these herbs is to clear heat, detoxify, reduce inflammation, relieve pain, promote tissue regeneration, and astringe sores. It is particularly suitable for symptoms such as postherpetic neuralgia and burning and stinging pain of the skin. It is highly targeted and has significant curative effect.

[0025] 2. In this invention, by optimizing the processing and preparation techniques, such as calcination or water-milling of mineral drugs, coarse pulverization of plant drugs, low-temperature grinding of borneol and Glauber's salt, and overall ultra-fine pulverization to D90 ≤ 15μm, the specific surface area and transdermal absorption rate of the drug are significantly improved. At the same time, the equal-incremental mixing method is used to ensure uniform and stable composition. Clinical observation of 60 patients showed that after applying this product externally twice a day for 14 days, the pain VAS score decreased significantly, sleep improved, and burning pain was relieved rapidly. Attached Figure Description

[0026] Figure 1 This is a flowchart of a traditional Chinese medicine formula for treating sequelae of shingles according to the present invention. Detailed Implementation

[0027] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0028] Example 1:

[0029] Please see Figure 1 As shown, the present invention provides a technical solution: a traditional Chinese medicine formula for treating sequelae of shingles, comprising the following raw materials in parts by weight: 47-52 parts of Phellodendron bark, 47-52 parts of rhubarb, 47-52 parts of Coptis chinensis, 47-52 parts of white powder, 47-52 parts of calamine, 47-52 parts of talc, 47-52 parts of otolith, 3-8 parts of borneol, 47-52 parts of gypsum, and 3-8 parts of mirabilite;

[0030] Further: Includes the following raw materials by weight: 50 parts of Phellodendron bark, 50 parts of rhubarb, 50 parts of Coptis chinensis, 50 parts of white powder, 50 parts of calamine, 50 parts of talc, 50 parts of otolith, 5 parts of borneol, 50 parts of gypsum, and 5 parts of mirabilite.

[0031] Example 2:

[0032] A traditional Chinese medicine formula for treating sequelae of shingles includes the following raw materials in parts by weight: 47-52 parts of Phellodendron bark, 47-52 parts of rhubarb, 47-52 parts of Coptis chinensis, 47-52 parts of white powder, 47-52 parts of calamine, 47-52 parts of talc, 47-52 parts of otolith, 3-8 parts of borneol, 47-52 parts of gypsum, and 3-8 parts of mirabilite;

[0033] Further: Includes the following raw materials by weight: 48 parts of Phellodendron bark, 47 parts of rhubarb, 48 parts of Coptis chinensis, 49 parts of white powder, 49 parts of calamine, 47 parts of talc, 47 parts of otolith, 4 parts of borneol, 47 parts of gypsum, and 4 parts of mirabilite.

[0034] Example 3:

[0035] A traditional Chinese medicine formula for treating sequelae of shingles includes the following raw materials in parts by weight: 47-52 parts of Phellodendron bark, 47-52 parts of rhubarb, 47-52 parts of Coptis chinensis, 47-52 parts of white powder, 47-52 parts of calamine, 47-52 parts of talc, 47-52 parts of otolith, 3-8 parts of borneol, 47-52 parts of gypsum, and 3-8 parts of mirabilite;

[0036] Further: Includes the following raw materials by weight: 49 parts of Phellodendron bark, 52 parts of rhubarb, 52 parts of Coptis chinensis, 48 ​​parts of white powder, 48 parts of calamine, 52 parts of talc, 52 parts of otolith, 6 parts of borneol, 51 parts of gypsum, and 6 parts of mirabilite.

[0037] The formula experiment table is as follows:

[0038]

[0039] Clinical observation experiment:

[0040] Subjects: 60 patients with postherpetic neuralgia, with a disease duration of 1–6 months;

[0041] Grouping: The patients were randomly divided into three groups, and each group used the powder prepared in Examples 1, 2, and 3 respectively. The powder was applied externally to the affected area twice a day for 14 days.

[0042] Evaluation indicators: pain VAS score, improvement in sleep quality, time to relief of burning / tingling sensation in the skin, and incidence of adverse reactions;

[0043] Experimental conclusion:

[0044] Clinical observations show that Example 1 has the fastest onset of action, Example 3 is more effective for intractable burning pain, and Example 2 is more suitable for the elderly and those with weak constitutions.

[0045] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine formula for treating sequelae of shingles, characterized in that, The ingredients include the following raw materials by weight: 47-52 parts of Phellodendron bark, 47-52 parts of rhubarb, 47-52 parts of Coptis chinensis, 47-52 parts of white powder, 47-52 parts of calamine, 47-52 parts of talc, 47-52 parts of otolith, 3-8 parts of borneol, 47-52 parts of gypsum, and 3-8 parts of mirabilite.

2. The traditional Chinese medicine formula for treating sequelae of shingles according to claim 1, characterized in that: The ingredients include the following raw materials by weight: 50 parts of Phellodendron bark, 50 parts of rhubarb, 50 parts of Coptis chinensis, 50 parts of white powder, 50 parts of calamine, 50 parts of talc, 50 parts of otolith, 5 parts of borneol, 50 parts of gypsum, and 5 parts of mirabilite.

3. The traditional Chinese medicine formula for treating sequelae of shingles according to claim 2, characterized in that: Includes the following steps: S1: Clean the Phellodendron bark, rhubarb, Coptis chinensis, and white peony root, removing impurities and non-medicinal parts, and wash them thoroughly. At the same time, remove mud and sand impurities from calamine, talc, otolith, and gypsum, wash and dry them. Also, store borneol and Glauber's salt separately in a cool, dry place to avoid moisture and volatilization. S2: Chop or coarsely grind the Phellodendron bark, rhubarb, Coptis chinensis, and white powder. Calcinate or water-levigate the mineral medicines such as calamine, talc, otolith, and calcite to improve purity and fineness. Grind borneol and calcined ... S3: The mixed coarse powder is pulverized to a fineness of 120 mesh or higher by an ultra-fine pulverizing device to improve the transdermal absorption rate of the drug and to fully mix the ultra-fine pulverized drug powder. S4: Using the equal-increment method, add the fine borneol powder to the mixed powder in batches, and operate in a sealed manner to prevent volatilization. Add the fine Glauber's salt powder to the above mixture. At the same time, sieve and mix repeatedly 3-4 times to ensure that each component is evenly distributed. S5: Conduct tests for appearance, particle size, moisture content, microbial limits, and content determination; S6: After passing inspection, the contents shall be packaged into light-proof, sealed containers according to specifications, and the net content of each bag / bottle shall meet the standard. S7: The quality authorized person reviews all production and inspection records, and issues a release order after confirming that they meet the standards.

4. The traditional Chinese medicine formula for treating sequelae of shingles according to claim 3, characterized in that: The calcination temperature in S2 is 400-600℃, the calcination time is 1-2 hours, and the amount of water added during water levigation is 3-5 times the weight of the powder. After stirring and settling, the upper suspension is taken, and after precipitation and drying, an extremely fine powder is obtained.

5. A traditional Chinese medicine formula for treating sequelae of shingles according to claim 4, characterized in that: The ultrafine grinding in S3 is carried out by air jet milling or vibration milling, with a grinding temperature of -10℃ to 10℃. The particle size of the pulverized medicine powder is D90≤15μm and the specific surface area is ≥1.5m² / g.

6. The traditional Chinese medicine formula for treating sequelae of shingles according to claim 5, characterized in that: The specific steps of the equal incremental method in S4 are as follows: S41: Place the borneol powder and an equal amount of mixed medicine powder in a mixer and mix for 5-10 minutes; S42: Add an equal amount of mixed powder to the mixture and continue mixing for 5-10 minutes; S43: Repeat the above steps until all the borneol has been added; S44: Add the fine powder of Glauber's salt in 2-3 batches, mixing for 5-10 minutes each time. Finally, pass it through a 120-mesh sieve 3-4 times. The total mixing time should not be less than 30 minutes. The relative humidity of the mixing environment should be controlled below 45%.

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