Processing system

Abstract

The present invention provides a treatment system for treating blood and / or body cavity fluid, the treatment system comprising: a filter; a pressurizing unit including a pump and a valve; a flow path connection part; a zero flow path that connects the drain outlet of the filter and the valve; a first flow path that connects the valve and the flow path connection part; a second flow path that connects the flow path connection part and a first connection port for first pressure measurement; a third flow path that connects the flow path connection part and the liquid discharge part; an inspection unit that inspects the connection between the second flow path and the first connection port; a first pressure measurement unit that measures the pressure in the flow path of a second flow path connected to the first connection port; and a control unit that controls the pressurizing unit, the control unit controls the pressurizing unit such that the valve is opened after the liquid filled in the zero flow path is pressurized in a state in which the valve is closed, and the inspection unit performs a connection inspection on the basis of the flow path internal pressure of the second flow path pressurized by opening the valve measured by the first pressure measurement unit.

Description

Technical Field

[0001] The present invention relates to a treatment system for treating blood and / or body cavity fluid. Background Art

[0002] As a treatment method for ascites, which is one of the body cavity fluids, there is a method called Cell-free and Concentrated Ascites Reinfusion Therapy. In this method, ascites is removed from the patient, the ascites is concentrated after pathogenic substances such as bacteria and cancer cells are removed from the ascites, and useful components such as albumin are left. The concentrated fluid is then returned to the body.

[0003] In this treatment method, a body cavity fluid treatment system is generally used (see Patent Document 1).

[0004] Prior art literature

[0005] Patent Literature

[0006] Patent Document 1: Japanese Patent Application Publication No. 2019-13492 Summary of the invention

[0007] Problem that the invention aims to solve

[0008] In the above-mentioned body cavity fluid treatment system and other blood treatment systems, the tubes that form the flow paths of each liquid, the bags for storing each liquid, the concentrators, and the filters must be replaced each time the treatment is performed. There are many parts and installation locations connected to the main body of the treatment system, and the replacement operation is complicated. In particular, when there is a poor connection between the flow path and the pressure measuring unit, the main body of the treatment system cannot correctly monitor the pressure in the tube.

[0009] The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to provide a processing system capable of inspecting the connection of a flow path to a pressure measuring unit.

[0010] Solutions for solving problems

[0011] That is, the present invention is as follows.

[0012] [1] A processing system for processing blood and / or body cavity fluid, wherein the processing system comprises: a filter; a pressurizing unit including a pump and a valve; a flow path connecting unit; a 0th flow path connecting a drainage outlet of the filter and the valve; a 1st flow path connecting the valve and the flow path connecting unit; a 2nd flow path connecting the flow path connecting unit and a 1st connection port for measuring a first pressure; a 3rd flow path connecting the flow path connecting unit and a drainage unit for storing drainage flowing out of the drainage outlet; and a testing unit for performing the 1st pressure measurement. A connection check between a first connection port for pressure measurement and the second flow path; a first pressure measuring unit, which measures the flow path pressure of the second flow path connected to the first connection port for pressure measurement; and a control unit, which controls the pressurizing unit, wherein the control unit controls the pressurizing unit so as to open the valve after pressurizing the liquid filled in the zero flow path in a state where the valve is closed, and the checking unit performs the connection check based on the flow path pressure of the second flow path pressurized by opening the valve, which is measured by the first pressure measuring unit.

[0013] [2] The processing system according to [1], wherein the first pressure measuring unit measures the pressure within the second flow path based on a timing when the valve changes from a closed state to an open state.

[0014] [3] The processing system according to [1] or [2], wherein the drainage section of the closed system is connected to the third flow path.

[0015] [4] A processing system according to any one of [1] to [3], wherein, during the connection check, when the pressure within the second flow path measured by the first pressure measuring unit is greater than a predetermined value, the inspection unit determines that the second flow path is connected to the first connection port for measuring the first pressure.

[0016] [5] The processing system according to any one of [1] to [4], wherein the inspection unit performs the connection inspection based on the flow channel internal pressure of the second flow channel before and after the pressurization measured by the first pressure measuring unit.

[0017] [6] A processing system according to any one of [1] to [5], wherein, in the connection check, when the difference in pressure within the second flow path before and after pressurization measured by the first pressure measuring unit is greater than a predetermined value, the inspection unit determines that the second flow path is connected to the first connection port for measuring the first pressure.

[0018] [7] A processing system according to any one of [1] to [6], wherein, during the connection check, the inspection unit measures the in-path pressure of the second path measured by the first pressure measuring unit multiple times and / or measures the difference in in-path pressure of the second path before and after pressurization measured by the first pressure measuring unit multiple times, and determines that the second path is connected to the first connection port for measuring the first pressure based on the multiple measurement results.

[0019] [8] A processing system according to any one of [1] to [7], wherein, during the connection check, the inspection unit changes the pressurization pressure of the pressurization unit and performs multiple confirmations on whether the second flow path is connected to the first connection port for measuring the first pressure, and during the connection check, the inspection unit determines that the second flow path is connected to the first connection port for measuring the first pressure based on the results of the multiple confirmations.

[0020] [9] The processing system according to any one of [1] to [8], wherein:

[0021] At least one of a flow path cross-sectional area, a flow path length, a flow path wall thickness, and a constituent material is different in at least a portion of the second flow path and the third flow path.

[0022]

[10] The processing system according to any one of [1] to [9], wherein a gas is sealed in a portion of the second flow path.

[0023]

[11] The processing system according to any one of [1] to

[10] , wherein the pressurizing unit includes a second pressure measuring unit that measures the pressurizing pressure.

[0024]

[12] A treatment system according to any one of [1] to

[11] , wherein the treatment system comprises: a concentrator, which is indirectly or directly connected to the filter; a fourth flow path, which discharges the waste liquid removed by the concentrator; a backflow prevention unit, which is arranged in the fourth flow path; and a branch point, which is arranged in the second flow path, and the fourth flow path is connected to the branch point.

[0025]

[13] The processing system according to any one of [1] to

[12] , further comprising an output unit for displaying a result of the connection check.

[0026] Effects of the Invention

[0027] According to the present invention, it is possible to provide a processing system capable of inspecting the connection of a flow path to a pressure measuring unit. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1AThis is a schematic diagram showing one form of the processing system according to the present embodiment.

[0029] Figure 1B This is a diagram showing an example of the hardware configuration of the information processing device according to the present embodiment.

[0030] Figure 1C This is a diagram showing an example of a functional block configuration of the information processing device according to the present embodiment.

[0031] Figure 1D It is a schematic diagram showing another form of the processing system according to the present embodiment.

[0032] Figure 2A It is a schematic diagram showing changes in the flow channel pressure of the 0th flow channel.

[0033] Figure 2B It is a schematic diagram showing changes in the pressure within the second flow path.

[0034] Figure 3A An example of a flowchart of the connection check is shown.

[0035] Figure 3B Another example of a flowchart of the connection check is shown.

[0036] Figure 4A This is a front view showing one form of the processing bag.

[0037] Figure 4B This is a front view showing one form of a processed bag.

[0038] Figure 4C This is a front view showing one form of the liquid discharge unit.

[0039] Figure 4D A schematic diagram showing one form of an ascites collection line.

[0040] Figure 4E A schematic diagram showing one form of the flow channel 14 is shown.

[0041] Figure 4F This is a diagram showing one form of the flow path 45 .

[0042] Figure 4G Yes means Figure 1A A diagram showing an example of the structure of the downstream portion from the 0th flow path.

[0043] Figure 4H Yes means Figure 1D A diagram showing an example of the structure of the downstream portion from the 0th flow path.

[0044] Fig. 4I Yes means Figure 1A A diagram showing an example of the structure of the downstream portion from the 4th flow path.

[0045] Figure 4J Yes means Figure 1D A diagram showing an example of the structure of the downstream portion from the 4th flow path.

[0046] Figure 4K It is a partial enlarged view of the flow circuit of the treatment system.

[0047] Figure 4L It is a partial enlarged view of the flow circuit of the treatment system.

[0048] Description of Reference Numerals

[0049] 1. Processing system; 2. Body fluid processing device; 10. Processing bag; 10a. Hook hole; 10b. Screen; 10c. Pipeline; 10d. End; 10e. Notch; 10f. Connector; 10g. Pipeline; 10h. Connector; 10i. Ascites collection pipeline; 10j. Connector; 10k. Connector; 10l. Regulator; 10m. Chamber; 10n. Port; 11. Filter; 11a. Liquid port; 11b. Liquid port; 11c. Liquid port; 11d. Liquid port; 12. Concentrator; 12a. Liquid port; 12b. Liquid port; 12c. Liquid port; 12d. Liquid port; 13. Processed bag; 13a. Hook hole; 13b. Pipeline; 13c. Pipeline; 13 d, connector; 13e, connector; 13f, port; 13g, port; 14, flow path; 14a, connector; 14b, connector; 14c, plastic needle; 14d, cover; 14e, mark; 14f, mark; 14g, connector; 15, flow path; 16, flow path; 17, the 4th flow path; 17a, connector; 17b, connector; 17c, connector; 17d, mark; 18, flow path; 19a, the 0th flow path; 19aa, connector; 19ab, mark; 19ac, mark; 19ad, branch flow path; 19ae, branch flow path; 19af, connector; 19ag, connector; 19b, the 1st flow path; 19c, the 2nd flow path; 19ca, drip bucket ; 19d, third flow path; 19da, connector; 19e, flow path connection; 19f, branch point; 20, flow path loop; 21, connector; 22, mark; 23, mark; 24, saline bag; 25, flow path; 25a, needle; 25b, connector; 30, filter membrane; 30a, space (inner space of hollow fiber membrane); 30b, space (outer space of hollow fiber membrane); 40, concentration membrane; 40a, space (inner space of hollow fiber membrane); 40b, space (outer space of hollow fiber membrane); 41, valve; 45, flow path; 45a, mark; 45b, drip bucket; 46, connection port; 50, valve; 51, pump; 52, drip bucket; 53, introduction part; 60 , pump; 65, backflow prevention part; 70, valve; 81, valve; 82, drainage part; 82a, hook hole; 82b, pipeline; 82c, pipeline; 82d, connector; 82e, stopcock; 83, second connection port; 84a, first connection port; 84b, connection port; 85, inspection part; 86, control part; 87, first pressure measuring part; 88, second pressure measuring part; 89, output part; 90, pressurizing part; 91, drainage part; 100, information processing device; 111, processor; 112, storage device; 114, input device; 115, output device; 130, storage part; 150, tube; 151, guide panel; 160, locking part; 161, pressing part; 162, groove part. DETAILED DESCRIPTION

[0050] Hereinafter, an embodiment of the present invention (hereinafter referred to as "the present embodiment") will be described in detail with reference to the accompanying drawings as needed, but the present invention is not limited thereto and can be variously modified within the scope of the main purpose thereof. It should be noted that in the accompanying drawings, the same elements are marked with the same reference numerals and repeated descriptions are omitted. In addition, the positional relationship such as up, down, left, and right is based on the positional relationship shown in the drawings unless otherwise specified. Moreover, the dimensional ratios of the drawings are not limited to the ratios shown in the drawings.

[0051] 1. Processing system

[0052] Figure 1A A schematic diagram showing one form of the treatment system of the present embodiment is shown. The treatment system 1 of the present embodiment is a treatment system for treating blood and / or body cavity fluid, and comprises: a filter 11; a pressurizing unit 90; a second connection port 83 connected to a drain unit 82; a first connection port 84a for measuring a first pressure; a flow path connection unit 19e; a 0th flow path 19a connecting the drain outlet of the filter 11 and a valve; a 1st flow path 19b connecting the valve 81 and the flow path connection unit 19e; a 2nd flow path 19c connecting the flow path connection unit 19e; and a first connection port 84a for measuring the first pressure; a third flow path 19d, which connects the flow path connecting portion 19e and the discharge portion 82 and has a second connection port 83; an inspection portion 85, which inspects the connection between the first connection port 84a for measuring the first pressure and the second flow path 19c; a first pressure measuring portion 87, which measures the pressure in the path of the second flow path connected to the first connection port 84a for measuring the first pressure; and a control portion 86, which controls the pressurizing portion 90.

[0053] It may be that the control unit 86 of the processing system 1 controls the pressurizing unit 90 to open the valve 81 after increasing the pressure acting on the liquid filled in the 0th flow path 19a in the state of closing the valve 81, the first pressure measuring unit 87 measures the flow path pressure of the second flow path 19c through the first connecting port 84a, and the inspection unit 85 performs a connection check based on the flow path pressure of the second flow path 19c pressurized by opening the valve 81.

[0054] A processing system for processing blood and / or body cavity fluid must be used by a user such as a medical practitioner by replacing all the flow paths each time it is used. Therefore, the inspection of whether the pressure measuring unit is connected to the flow path depends on the medical practitioner. In contrast, according to this embodiment, the processing system can reliably perform the inspection of the connection of the flow path to the pressure measuring unit without relying on the medical practitioner. In addition, the processing system can reliably perform the inspection of the connection of the flow path to the pressure measuring unit in a relatively short time.

[0055] In addition, the state where a part of the flow path is connected to a drainage bag or the like becomes almost indistinguishable and close to the open end state. In such a case, when a connection check is performed based on the pressure in the flow path increased by flowing liquid into the drainage bag or the like, it may take time for the pressure to increase, so there is a concern that the connection check cannot be performed quickly. In contrast, according to this embodiment, the processing system can reliably perform a check on the connection of the flow path to the pressure measuring unit.

[0056] The following is based on Figure 1A The form of the treatment system 1 of this embodiment will be described in detail. First, the treatment system 1 may include a treatment bag 10 as a storage part for untreated blood and / or body cavity fluid, a filter 11, a concentrator 12, a processed bag 13 as a recovery part for blood and / or body cavity fluid after filtration and concentration, and an information processing device 100. The information processing device 100 may also include various functional parts such as an inspection part 85, a control part 86, a first pressure measurement part 87, and a second pressure measurement part 88.

[0057] Hereinafter, the structure of the processing system 1 will be described by taking the processing of ascites as an example of body cavity fluid, but the processing target of the processing system 1 of this embodiment is not limited to ascites, and the processing system 1 can also be applied to other body cavity fluids and blood.

[0058] The processing bag 10 is, for example, a soft bag that can contain ascites collected from a patient. During the connection test, the processing bag 10 can contain liquid such as physiological saline or water or gas such as air.

[0059] Figure 4A The front view of the treatment bag 10 is shown. The treatment bag 10 is not particularly limited, and can be, for example, a flat, roughly rectangular bag made of soft polyvinyl chloride. In addition, its capacity can be about 3L, and its size can be about 350mm long and about 250mm wide. The treatment bag 10 can have a capacity scale (not shown) for indicating the capacity of the content liquid, and a user identification mark (not shown) indicating the patient whose ascites filled into the treatment bag 10 has been collected. The capacity scale and the user identification mark can be attached to the bag body or directly printed on the bag body, or formed on the bag body by other methods.

[0060] A sealing portion of a certain width is provided on all four sides of the treatment bag 10. A hook hole 10a can be provided on the sealing portion. There can be a plurality of hook holes 10a, for example, they can be provided at the center of the upper side and the corner of the lower side of the sealing portion.

[0061] In addition, a mesh portion 10b may be provided inside the processing bag 10. When the ascites is transferred from the processing bag 10 to the filter 11 via the pipeline 10c, the coagulation of the ascites can be prevented or the coagulated ascites can be prevented from flowing toward the filter 11. This can also prevent the flow path 14 from being clogged.

[0062] The pipeline 10c may be located below the sealing portion, or may extend to the outside and inside of the processing bag 10 respectively to connect the outside and inside of the processing bag 10. In addition to the opening at the end 10d, the portion of the pipeline 10c extending to the inside of the processing bag 10 may also be provided with an opening formed by the notch 10e. The ascites in the processing bag 10 may flow from the notch 10e and the end 10d to the filter 11 via the pipeline 10c. The notch 10e allows the ascites to flow out stably. Therefore, the notch 10e and the opening of the end 10d can be designed to be smaller, thereby preventing the coagulated ascites from flowing out to the filter 11. In addition, the connector 10f connected to the flow path 14 when filtering and concentrating the ascites may also be located in the portion of the pipeline 10c extending to the outside.

[0063] It should be noted that in Figure 4A In order to show the end 10d and the recess 10e, the mesh portion 10b is omitted from the portion, which does not mean that there is no mesh portion 10b around the end 10d and the recess 10e of the pipeline 10c.

[0064] Furthermore, the processing bag 10 may also have a pipeline 10g that connects the outside and the inside of the processing bag 10. The pipeline 10g may also be located below the sealing portion. The connector 10h connected to the ascites collection pipeline when collecting ascites may also be located in the portion of the pipeline 10g that extends to the outside. It should be noted that the connector 10f and the connector 10h are preferably one male type and the other female type to avoid mistaking the connection object.

[0065] Figure 4D FIG. 1 shows a form of an ascites collection pipeline 10i. Figure 4D As shown, the ascites collection line 10i has a connector 10j connected to a puncture needle or the like for collecting ascites from a patient and a connector 10k connected to the line 10g. In addition, the ascites collection line 10i may also include a regulator 10l (Roller Clamp) for regulating the flow rate and a chamber 10m for visually recognizing the flow rate (speed of droplets). The connectors 10j and 10k may also be covered with caps before being connected.

[0066] In addition, the processing bag 10 may have a port 10n for collecting a part of the original ascites or injecting a drug or the like.

[0067] The filter 11 has, for example, a cylindrical shell. The filter 11 has liquid passages 11a and 11b at both ends in the length direction (up and down direction), and two liquid passages 11c and 11d on the side. The filter 11 can, for example, remove specified pathogenic substances such as bacteria and cancer cells and allow specified useful components such as albumin to pass through. It should be noted that during the connection inspection, liquids such as physiological saline and water or gases such as air can be passed through each space in the filter 11. It should be noted that in this specification, the up and down of the processing system 1 is based on the posture during normal use.

[0068] The filter 11 includes a filter membrane 30 that removes predetermined pathogenic substances such as bacteria and cancer cells and allows predetermined useful components such as albumin to pass through. The filter membrane 30 is composed of, for example, a plurality of hollow fiber membranes. The space 30a on the primary side of the filter membrane 30 (the internal space of the hollow fiber membrane) is communicated with the liquid-passing ports 11a and 11b, and the space 30b on the secondary side of the filter membrane 30 (the external space of the hollow fiber membrane) is communicated with the liquid-passing ports 11c and 11d.

[0069] A flow path 45 is connected to the liquid passage 11c of the filter 11. The flow path 45 is connected to the connection port 46. The second pressure measuring part 88 can also be connected to the connection port 46. The second pressure measuring part 88 can be a pressure measuring device such as a pressure sensor. That is, the flow path 45 can also be connected to the pressure sensor via the connection port 46. In addition, the connection port 46 can also be an atmosphere-opening part that can introduce gas into the filter 11 through the flow path 45. The connection of the flow path 45 can be checked by pressurizing the filter 11 with the pump 51 in a state where the valves 41 and 81 are closed and the valve 50 is opened. The connection port 46 can be configured to be switchable between the second pressure measuring part 88 and the atmosphere-opening part. The connector of the flow path 45 connected to the liquid passage 11c can also be covered with a cap in a state before being connected to the vent 11c.

[0070] Figure 4F One form of the flow path 45 is shown. Marks 45a such as colors may be marked on both ends of the flow path 45. Thus, the user can easily confirm the connection object (e.g., the liquid port 11c, the second pressure measuring unit 88) based on the marks 45a. In addition, the flow path 45 may also have a drip funnel 45b.

[0071] The concentrator 12 has, for example, a cylindrical shell. The concentrator 12 has liquid passages 12a and 12b at both ends in the longitudinal direction (up and down direction), and two liquid passages 12c and 12d on the side. The concentrator 12 can also remove water from ascites to concentrate it. It should be noted that during the connection inspection, liquids such as physiological saline and water or gases such as air can be passed through each space in the concentrator 12.

[0072] The concentrator 12 includes, for example, a concentrating membrane 40 for removing water from ascites to perform concentration. The concentrating membrane 40 is composed of, for example, a plurality of hollow fiber membranes. A space 40a on the primary side of the concentrating membrane 40 (the inner space of the hollow fiber membrane) communicates with the liquid passages 12a and 12b, and a space 40b on the secondary side of the concentrating membrane 40 (the outer space of the hollow fiber membrane) communicates with the liquid passages 12c and 12d.

[0073] The processed bag 13 is, for example, a soft bag, and can contain concentrated ascites concentrated by the concentrator 12. The processed bag 13 may be provided at a lower position than the processing bag 10. During the connection inspection, the processed bag 13 may contain liquid such as physiological saline or water or gas such as air after passing through the concentrator 12.

[0074] Figure 4B The front view of the treated bag 13 is shown. The treated bag 13 is not particularly limited, and can be, for example, a flat, roughly rectangular bag made of soft polyvinyl chloride. In addition, its capacity can be about 1L, and its size can be about 290mm long and about 150mm wide. The treated bag 13 can have a capacity scale (not shown) for indicating the capacity of the content liquid, and a user identification mark (not shown) indicating the patient whose ascites is collected in the treated bag 13. The capacity scale and the user identification mark can be attached to the bag body or directly printed on the bag body, or formed on the bag body by other methods.

[0075] A sealing portion of a certain width is provided on all four sides of the processed bag 13. A hook hole 13a can be provided on the sealing portion. There can be a plurality of hook holes 13a, for example, they can be provided at the center of the upper side and the corner of the lower side of the sealing portion.

[0076] The processed bag 13 may also have a pipeline 13b and a pipeline 13c below the sealing portion. The pipeline 13b and the pipeline 13c may also communicate the outside and the inside of the processed bag 10, respectively. The connectors 13d and 13e may also be located at the portions of the pipeline 13b and the pipeline 13c extending to the outside, respectively. The pipeline 13b is connected to the flow path 16 via the connector 13d. In addition, the pipeline 13c is connected to the flow path 18 via the connector 13e. It should be noted that, preferably, one of the connectors 13d and 13e is a male type and the other is a female type to avoid mistaking the connection object.

[0077] In addition, the processed bag 13 may have a port 13f for collecting a portion of the concentrated ascites or injecting a drug, and a port 13g for connecting to a puncture needle when the ascites is intravenously reinfused.

[0078] The flow path 14 connects the treatment bag 10 and the filter 11. The upstream end of the flow path 14 is connected to the treatment bag 10, and the downstream end of the flow path 14 is connected to the liquid port 11a of the filter 11. During the connection inspection, liquids such as physiological saline and water or gases such as air can flow from the treatment bag 10 into the liquid port 11a of the filter 11 through the flow path 14. In addition, during treatment, ascites can flow from the treatment bag 10 into the liquid port 11a of the filter 11 through the flow path 14. The flow path 14 may also be provided with a valve 41 for opening and closing the flow path 14. It should be noted that in this specification, "upstream side" means the direction that becomes the upstream side during normal ascites treatment in which ascites flows in the order of the filter 11 and the concentrator 12, and "downstream side" means the direction that becomes the downstream side during normal ascites treatment.

[0079] Figure 4E A schematic diagram of the flow path 14 is shown. The flow path 14 may include a connector 14a connected to the processing bag 10 and a connector 14b connected to the filter 11. The flow path 14 may include a plastic needle 14c that can be detached from the top of the connector 14a before being connected to the processing bag 10. The flow path 14 can be applied to both a physiological saline bag connected by the plastic needle 14c and a physiological saline bag connected by the connector 14g. It should be noted that the plastic needle 14c may be covered with a cap 14d before being connected. In addition, the connector 14b may also be covered with a cap before being connected.

[0080] For example, the plastic needle 14c can be used to pierce the rubber stopper of the saline bag to perform priming. In this case, the plastic needle 14c can be connected to the saline bag during priming, and the flow path is filled with saline for cleaning. After priming, the plastic needle 14c is removed from the connector 14a, and the connector 14a is connected to the pipeline 10c of the processing bag 10.

[0081] In this embodiment, "priming injection" refers to the following operation: before ascites filtration and concentration, at least a portion of the flow path of the treatment system is filled with physiological saline, and the physiological saline is circulated to at least a portion of the flow path of the treatment system by the drive of a pump or the like and the weight of the physiological saline. "Physiological saline bag" refers to a bag filled with physiological saline for priming injection.

[0082] The flow path 14 may also have a mark 14e for clearly indicating the connection position to the on-off valve (valve 41). This makes it easy to set the on-off valve (valve 41) at an appropriate position of the flow path 14 (between the two marks 14e). In addition, a mark 14f such as a color may be marked on the end side of the flow path 14. Thus, the user can easily confirm the connection object (e.g., the processing bag 10, the filter 11) based on the mark 14f.

[0083] The 0th flow path 19a connects the filter 11 and the valve 81. The end on the upstream side of the 0th flow path 19a is connected to the discharge outlet 11b of the filter 11. In addition, the end on the downstream side of the 0th flow path 19a is connected to the valve 81. During the connection inspection, liquids such as physiological saline and water or gases such as air can flow from the discharge outlet 11b of the filter 11 toward the valve 81 via the 0th flow path 19a. In addition, the liquid or gas supplied to the valve 81 can be pressurized by a pump that can pressurize the liquid or gas filled in the 0th flow path 19a. In addition, during the treatment, the filtered and discarded ascites can flow from the discharge outlet 11b of the filter 11 via the 0th flow path 19a toward the valve 81. The filtered ascites may contain prescribed pathogenic substances such as bacteria and cancer cells.

[0084] The first flow path 19b connects the valve 81 and the flow path connection portion 19e. The upstream end of the first flow path 19b is connected to the valve 81. In addition, the downstream end of the first flow path 19b is connected to the flow path connection portion 19e. During the connection inspection, liquids such as physiological saline and water or gases such as air flow into the first flow path 19b as the valve 81 is opened. In addition, during the membrane cleaning of the filter 11, physiological saline used for membrane cleaning flows from the valve 81 into the first flow path 19b.

[0085] The 0th flow path 19a and the 1st flow path 19b are not particularly limited as long as they are located upstream and downstream of the valve 81, and may be the same pipe or different pipes.

[0086] Figure 4G Show Figure 1A An example of a structure of the downstream portion from the 0th flow path 19a in the form shown. The 0th flow path 19a may have a connector 19aa connected to the filter 11. In addition, the 0th flow path 19a may also have a mark 19ab for clearly indicating the connection portion connected to the on-off valve (valve 81). Thus, it is easy to set the on-off valve (valve 81) at an appropriate position of the 0th flow path 19a (between the two marks 19ab). In addition, a mark 19ac such as color may be marked on the end side of the 0th flow path 19a. Thus, the user can easily confirm its connection object (for example, the filter 11) based on the mark 19ac. The connector 19aa may also be covered with a cap in the state before connection.

[0087] In addition, if Figure 4G As shown, the first flow path 19b may have a branch flow path 19ad and a branch flow path 19ae between the valve 81 and the flow path connecting portion 19e. The branch flow path 19ad may have a connector 19af at the end. In addition, the branch flow path 19ae may have a connector 19ag at the end. It should be noted that, as shown in FIG. Figure 4GAs shown, preferably, one of the connector 19af and the connector 19ag is of a male type and the other is of a female type, and they are connected to each other when filtering and concentrating ascites.

[0088] When starting the refueling and checking the connection, connector 19af and connector 19ag may not be connected to each other, one of connectors 19af and 19ag may be directly or indirectly connected to one of connectors 13d and 13e, and the other of connectors 19af and 19ag may be directly or indirectly connected to the other of connectors 13d and 13e.

[0089] like Figure 4G As shown, the second flow path 19c may be provided with a dripping funnel 19ca. In addition, one end of the second flow path 19c may be connected to a pressure measuring device via the first connection port 84a to measure the internal pressure of the second flow path 19c. In addition, the third flow path 19d may have a connector 19da connected to the discharge portion 82 storing the discharge liquid flowing out of the discharge outlet 11b. The connector 19da is equivalent to an example of the connection port 83.

[0090] Here, the valve 81 and the pump 51 located in the flow path 15 can constitute a pressurizing unit 90. Specifically, when the pump 51 delivers liquid in the direction F1, the liquid is supplied from the liquid passage 11d of the filter 11 to the space 30b on the secondary side, and the liquid is supplied to the space 30a on the primary side through the filter membrane 30, and the liquid flows from the liquid passage 11b into the 0th flow path 19a.

[0091] When the pump 51 delivers the liquid in the direction F1, if the valve 81 is closed, the pressure acting on the liquid filled in the 0th flow path 19a rises. That is, the pump 51 pressurizes the liquid filled in the 0th flow path 19a. And, after the pressure acting on the liquid filled in the 0th flow path 19a rises, the valve 81 is opened, so that the liquid supplied to the 0th flow path 19a flows into the 1st flow path 19b. In this way, the valve 81 and the pump 51 can constitute the pressurizing part 90 of the 1st flow path 19b.

[0092] The above describes the form of the pressurizing section 90 formed by the valve 81 and the pump 51, but the form of the pressurizing section 90 is not limited thereto. The pump constituting the pressurizing section 90 is not limited to the pump 51, and any pump that can pressurize the liquid or gas filled in the 0th flow path 19a is sufficient. For example, the pump constituting the pressurizing section 90 is not limited to the pump 51 provided in the flow path 15, and may be a pump provided in the 0th flow path 19a (not shown).

[0093] It should be noted that the operation of the pressurizing unit 90, that is, the opening and closing control of the valve 81 and the driving control of the pump 51 or other pumps can also be performed by the control unit 86. The control unit 86 can also control the pressurizing pressure of the pressurizing unit 90. The control unit 86 can open the valve 81 when the pressure acting on the liquid filled in the 0th flow path 19a exceeds a threshold value.

[0094] In addition, the processing system 1 may include a pressure measuring unit for measuring the pressurized pressure. The pressurized pressure measuring unit measures the pressure acting on the liquid filled in the 0th flow path 19a. As an example of the pressure measuring unit, the processing system 1 may include a second pressure measuring unit 88 for measuring the pressurized pressure. The second pressure measuring unit 88 measures the pressure acting on the liquid filled in the 0th flow path 19a.

[0095] The second flow path 19c connects the flow path connection part 19e and the first connection port 84a for measuring the first pressure. One end of the second flow path 19c is connected to the flow path connection part 19e. In addition, the other end (connection port 84b) of the second flow path 19c is connected to the first connection port 84a for measuring the first pressure. A second pressure measuring part 88 may also be connected to the connection port 46. The second pressure measuring part 88 is a pressure measuring device such as a pressure sensor. That is, the flow path 45 can be connected to the pressure sensor via the connection port 46. Alternatively, a first pressure measuring device such as a pressure sensor is connected to the first connection port 84a for measuring the first pressure and is closed. In other words, the second flow path 19c may not be a flow path for liquid or gas to pass through, but a flow path that transmits the inflow pressure generated by the liquid or gas from the flow path connection part 19e to the first connection port 84a.

[0096] During the connection inspection, the second flow path 19c only needs to transmit the pressure of the liquid such as physiological saline, water, or gas such as air to flow into the first connection port 84a from the flow path connection portion 19e at a predetermined pressure to the first connection port 84a. In addition, during the treatment, the second flow path 19c can also transmit the inflow pressure from the flow path connection portion 19e to the first connection port 84a.

[0097] Gas may be sealed in a part of the second flow path 19c, or a dripping funnel 19ca may be provided, thereby preventing the liquid from contacting the first pressure measuring device.

[0098] The third flow path 19d connects the flow path connection portion 19e and the second connection port 83 connected to the drain portion 82. The end portion on the upstream side of the third flow path 19d is connected to the flow path connection portion 19e. In addition, the end portion on the downstream side of the third flow path 19d has the second connection port 83 connected to the drain portion 82. During the connection inspection and processing, the second connection port 83 can be connected to the drain portion 82 that contains liquid or gas discharged from the filter 11, for example.

[0099] The drainage part 82 may be a closed system or an open system. From the viewpoint of preventing the drainage from contaminating other parts, it is preferred that the drainage part 82 of the closed system is connected to the second connection port 83. The drainage part 82 may also be, for example, a soft bag capable of containing ascites filtered out by the filter 11. During the connection inspection, liquids such as physiological saline, water, or gases such as air after passing through the filter 11 may be contained in the drainage part 82.

[0100] Figure 4C The front view of the drainage section 82 is shown. The drainage section 82 is not particularly limited, and may be, for example, a flat, roughly rectangular bag made of soft polyvinyl chloride. In addition, its capacity may be about 5L, and its size may be about 390mm long and about 280mm wide. The drainage section 82 may have a capacity scale (not shown) for indicating the capacity of the content liquid, and a user identification mark (not shown) indicating the patient whose ascites filled into the drainage section 82 has been collected. The capacity scale and the user identification mark may be affixed to the bag body or directly printed on the bag body, or formed on the bag body by other methods.

[0101] A sealing portion of a certain width is provided on all four sides of the liquid discharge portion 82. A hook hole 82a can be provided on the sealing portion. There can also be multiple hook holes 82a, for example, one or more can be provided on the upper side of the sealing portion, and one or more can be provided on the lower side.

[0102] The drain portion 82 may also include a pipeline 82b located above the sealing portion and a pipeline 82c located below the sealing portion. The pipeline 82b and the pipeline 82c may also communicate the outside and the inside of the drain portion 82, respectively. The connector 82d connected to the third flow path 19d may be located at the portion of the pipeline 82b extending to the outside. In addition, the stopcock 82e may be located at the portion of the pipeline 82c extending to the outside.

[0103] In addition, a drain portion 91 described later may also be configured similarly to the drain portion 82 .

[0104] The inspection unit 85, the control unit 86, the first pressure measuring unit 87, and the second pressure measuring unit 88 may be functional units of the information processing device 100 included in the processing system 1. The information processing device 100 is not particularly limited, and examples thereof include computers such as tablet computers and personal computers.

[0105] Figure 1B1 is a diagram showing an example of the hardware structure of the information processing device 100. The information processing device 100 has: a processor 111 such as a CPU (Central Processing Unit) and a GPU (Graphical Processing Unit); a storage device 112 such as a memory, an HDD (Hard Disk Drive) and / or an SSD (Solid State Drive); a communication IF (Interface) 113 for wired or wireless communication; an input device 114 for receiving input operations; and an output device 115 for outputting information. The input device 114 is, for example, a keyboard, a touch panel, a mouse and / or a microphone. The output device 115 is, for example, a display, a touch panel and / or a speaker.

[0106] Figure 1C : is a diagram showing an example of a functional block structure of an information processing device 100. The information processing device 100 may include an inspection unit 85, a control unit 86, a first pressure measuring unit 87, a second pressure measuring unit 88, and an output unit 89. The storage unit 130 can be implemented using a storage device 112 provided in the information processing device 100. In addition, the inspection unit 85, the control unit 86, and the output unit 89 can be implemented by executing a program stored in the storage device 112 by the processor 111 of the information processing device 100. In addition, the program can be stored in a storage medium. The storage medium storing the program can also be a non-transitory computer readable medium. The non-transitory storage medium is not particularly limited, and may be, for example, a storage medium such as a USB memory or a CD-ROM.

[0107] In the present embodiment, the connection check can also be performed by the joint action of the inspection unit 85, the first pressure measuring unit 87 and the control unit 86. In addition, during the inspection, the second pressure measuring unit 88 that measures the pressurized pressure of the pressurizing unit 90 can also further work together. Specifically, the control unit 86 of the processing system 1 controls the pressurizing unit 90 so that the valve 81 is opened after the 0th flow path 19a is pressurized by the pump 51 or the like in the state of closing the valve 81, the first pressure measuring unit 87 measures the flow path pressure of the second flow path 19c, and the inspection unit 85 performs the connection check based on the flow path pressure of the second flow path 19c pressurized by opening the valve 81. In addition, at this time, the second pressure measuring unit 88 can also measure the flow path pressure of the 0th flow path 19a after the pressurization of the pressurizing unit 90, and transmit information related to the flow path pressure of the 0th flow path 19a to the control unit 86 and / or the inspection unit 85.

[0108] The inspection unit 85 inspects the connection of the second flow path 19c with respect to the first connection port 84a for measuring the first pressure. In the connection inspection, when the pressure in the flow path of the second flow path 19c measured by the first pressure measuring unit 87 is greater than a predetermined value, the inspection unit 85 determines that the second flow path 19c is connected to the first connection port 84a for measuring the first pressure. When the pressure in the flow path is greater than a predetermined value, it can be said that there is no poor connection and the pressure is transmitted to the second flow path 19c. On the other hand, for example, when the pressure in the flow path of the second flow path 19c measured by the first pressure measuring unit 87 is less than a predetermined value, it can be considered that there is a poor connection somewhere in the flow path. It should be noted that the inspection unit 85 can also inspect whether the flow path 45 is connected to the connection port 46. Specifically, the inspection unit 85 inspects whether the flow path 45 is connected to the connection port 46 based on the pressure measured when the pump 51 is driven to pressurize the flow path 45 in a state where the valves 41 and 81 are closed and the valve 50 is opened. The connection inspection method of the flow path 45 is different from the inspection method of the flow path 19c described later. That is, the inspection unit 85 performs the connection inspection by the connection inspection method corresponding to the connection port.

[0109] In addition, during the connection check, the inspection unit 85 may also perform the connection check based on the pressure in the flow path of the second flow path 19c before and after pressurization measured by the first pressure measuring unit 87. At this time, it may be determined that the second flow path 19c is connected to the first connection port 84a for first pressure measurement when the difference in the pressure in the flow path before and after pressurization is greater than a predetermined value. Here, the pressure in the flow path before and after pressurization may also be referred to as the pressure in the flow path before and after the valve 81 of the pressurizing unit 90 is opened. When there is a change in the pressure in the flow path before and after pressurization, it can be said that the pressure caused by the opening of the valve 81 is transmitted to the second flow path 19c. And, when the amount of change, that is, the difference in the pressure in the flow path before and after pressurization, is greater than a predetermined value, it can be said that there is no poor connection, and the pressure is transmitted to the first pressure measuring unit 87 via the second flow path 19c. On the other hand, for example, when the difference in the pressure in the flow path before and after pressurization is less than a predetermined value, it can be considered that there is a poor connection somewhere in the flow path.

[0110] The control unit 86 controls the pressurizing unit 90. In addition, the control unit 86 can control the operation of each device such as the pump 51, the pump 60, the valve 50, and the valve 70 to perform connection check processing and blood and / or body cavity fluid processing. The control unit 86 can implement each processing by, for example, using the CPU to execute a program stored in the memory.

[0111] Figure 2A FIG. 8 shows a change in the pressure in the flow path of the 0th flow path 19a when the control unit 86 controls the pressurizing unit 90 as follows: the 0th flow path 19a is pressurized by the pump 51 or the like while the valve 81 is closed, and then the valve 81 is opened. Figure 2AAs shown, if the valve 81 is closed and the 0th flow path 19a is pressurized and then opened, the pressure in the 0th flow path 19a decreases with the passage of time from the time when the valve 81 is opened. It should be noted that the pressure in the 0th flow path 19a can also be measured by the second pressure measuring unit 88.

[0112] Figure 2B FIG. 8 is a diagram showing a change in the pressure in the second flow path 19c when the control unit 86 controls the pressurizing unit 90 in the following manner: the pressure acting on the liquid filled in the 0th flow path 19a is increased by the pump 51 or the like while the valve 81 is closed, and the valve 81 is opened when the pressure acting on the liquid filled in the 0th flow path 19a exceeds a threshold value. Figure 2B As shown in FIG. 1 , if the valve 81 is closed and the pressure acting on the liquid filled in the 0th flow path 19a is increased, and then the valve 81 is opened, the pressure in the flow path of the 2nd flow path 19c will temporarily increase as time passes from the time when the valve 81 is opened, but as the pressure from the 0th flow path 19a decreases, the pressure in the flow path of the 2nd flow path 19c decreases thereafter. It should be noted that the pressure in the flow path of the 2nd flow path 19c is measured by the first pressure measuring unit 87, but this is not limited to this, and it can also be measured by other methods.

[0113] like Figure 2A and Figure 2B As shown, by opening after the pressure acting on the liquid filled in the 0th flow path 19a is increased, the pressure in the flow path of the second flow path 19c can be sufficiently changed. In addition, when the inspection unit 85 detects such a change, it can be determined that the second flow path 19c is normally connected to the first connection port 84a. When the first pressure measuring unit 87 fails to detect the pressure change despite the pressurized 0th flow path 19a being opened, it can be determined that the second flow path 19c is not connected to the first connection port 84a or there is a problem in the connection. By using such a processing system to detect the change in the flow path pressure of the second flow path 19c, it is possible to reliably inspect the connection between the second flow path 19c and the first connection port 84a. More specifically, since the first flow path 19b is branched into the second flow path 19c and the third flow path 19d, it becomes a structure in which the second flow path 19c is difficult to be pressurized compared to the case where there is no branch. However, since the pressure acting on the liquid filled in the 0th flow path 19a is increased in the state of closing the valve 81 as described above, the pressure transmitted to the 2nd flow path 19c also becomes high at the moment the valve 81 is opened. Therefore, the connection of the 2nd flow path 19c to the 1st connection port 84a can be reliably checked.

[0114] The first pressure measuring unit 87 measures the pressure in the second flow path 19c connected to the first connection port 84a for measuring the first pressure. At this time, the first pressure measuring unit 87 can measure the pressure in the second flow path 19c based on the moment when the valve changes from a closed state to an open state. For example, the first pressure measuring unit 87 can measure the pressure in the second flow path 19c within a predetermined time from the moment when the valve 81 becomes an open state. In addition, the first pressure measuring unit 87 can also measure the pressure in the second flow path 19c as shown in FIG. Figure 2A , Figure 2B The first pressure measuring unit 87 measures the pressure of the second flow path 19c over time as shown in the figure, and the inspection unit 85 inspects the connection of the second flow path 19c with respect to the first connection port 84a for measuring the first pressure based on the opening time and the difference between the pressure at the opening time and the pressure at the time after a predetermined time from the opening time. The first pressure measuring unit 87 is connected to a drip chamber (not shown) for example, and can measure the pressure of the second flow path 19c. The measurement result of the first pressure measuring unit 87 can be output to the inspection unit 85 and the control unit 86, for example.

[0115] The second pressure measuring unit 88 can also measure the pressure acting on the liquid filled in the 0th flow path 19a after the control unit 86 controls the pressurizing unit 90 to increase the pressure. The second pressure measuring unit 88 is connected to the flow path 45, for example, and can measure the pressure acting on the liquid filled in the 0th flow path 19a. The measurement result of the second pressure measuring unit 88 can be output to the inspection unit 85 and the control unit 86, for example.

[0116] The output unit 89 can display the result of the connection check. When the output device 115 has a display, the output unit 89 can be controlled to display the result of the connection check. In addition, when the output device 115 has a speaker, the output unit 89 can also output the result of the connection check, such as an alarm of a poor connection, by sound.

[0117] The storage unit 130 may have various data used in the connection check, for example, data measured by the first pressure measuring unit 87 and the second pressure measuring unit 88, various predetermined values ​​for determining whether the connection is established, and the like.

[0118] The flow path 15 connects the filter 11 and the concentrator 12. The upstream end of the flow path 15 is connected to the liquid passage 11d of the filter 11, and the downstream end of the flow path 15 is connected to the liquid passage 12a at the upper end of the concentrator 12. That is, the liquid passage 11d of the filter 11 becomes the outlet of the filter 11, and the liquid passage 12a of the concentrator 12 becomes the inlet of the concentrator 12. During the connection inspection, physiological saline can flow from the physiological saline bag 24 to the filter 11 side through the flow path 15 in the direction F1. In addition, during the treatment, the filtered ascites can flow from the filter 11 side to the concentrator 12 side through the flow path 15. The filtered ascites can contain a predetermined useful component such as albumin.

[0119] For example, the flow path 15 may be provided with a valve 50, a pump 51, a dripping funnel 52, and an introduction portion 53 in order from the upstream side to the downstream side. In addition, a valve 25d may be provided between the dripping funnel 52 and the concentrator 12 in the flow path 15. The valve 50 and the valve 25d are configured to open and close the flow path 15.

[0120] The pump 51 can constitute the pump in the pressurizing unit 90. The pump 51 is not particularly limited, and can be, for example, a tube pump that presses the tube of the flow path 15 to pump liquid or gas in predetermined directions F1, F2, or can close the tube when stopped to function as a closing mechanism.

[0121] The introduction portion 53 may be a portion that introduces a gas such as air into the flow path 15 during a connection inspection.

[0122] The flow path 16 connects the concentrator 12 and the treated bag 13. The upstream end of the flow path 16 is connected to the liquid passage 12b at the lower end of the concentrator 12, and the downstream end of the flow path 16 is connected to the treated bag 13. That is, the liquid passage 12b of the concentrator 12 serves as the first outlet of the concentrator 12.

[0123] The flow path 16 may be provided with a pump 60. The pump 60 may be a tube pump that delivers liquid by squeezing the tube of the flow path 16. The pump 60 may also function as a sealing member by closing the tube when stopped.

[0124] The end on the upstream side of the fourth flow path 17 is connected to, for example, the liquid passage ports 12c and 12d of the concentrator 12. That is, the liquid passage ports 12c and 12d of the concentrator 12 serve as the second outlet of the concentrator 12. It should be noted that the end on the upstream side of the fourth flow path 17 may be connected to only one of the liquid passage ports 12c and 12d. The end on the downstream side of the fourth flow path 17 may also be connected to the drainage portion 91 that receives the drainage removed from the ascites by the concentrator 12.

[0125] Fig. 4I Show Figure 1AThe fourth flow path 17 in the embodiment shown is a structural example. The fourth flow path 17 may include connectors 17a and 17b connected to the liquid passages 12c and 12d of the concentrator 12. In addition, a backflow prevention portion 65 may be provided in the fourth flow path 17. The backflow prevention portion 65 can prevent the liquid discharged from the concentrator 12 from flowing back in the fourth flow path 17. In addition, the fourth flow path 17 may include a connector 17c connected to the drain portion 91. The connectors 17a, 17b, and 17c may be covered with a cap before being connected.

[0126] In addition, a mark 17d such as a color may be provided on the end side of the fourth flow channel 17. Thus, the user can easily confirm the connection object (for example, the concentrator 12 or the drain unit 91) based on the mark 17d.

[0127] The drainage part 91 may be a closed system or an open system. From the viewpoint of preventing the drainage from contaminating other parts, the drainage part 91 of a closed system is preferred. The drainage part 91 may be, for example, a soft bag that can contain the liquid discharged during the process of concentrating the ascites using the concentrator 12. During the connection inspection, the drainage part 91 may contain liquids such as physiological saline and water or gases such as air after passing through the concentrator 12.

[0128] The flow path 18 connects the treated bag 13 and the flow path 15. One end of the flow path 18 is connected to the treated bag 13. The other end of the flow path 18 can be connected to a portion of the flow path 15 between the valve 50 and the pump 51. The flow path 18 can also be provided with a valve 70 for opening and closing the flow path 18.

[0129] It should be noted that, for the 0th flow path 19a, the 1st flow path 19b, the 2nd flow path 19c, the 3rd flow path 19d, and the flow paths 14 to 18, for example, a soft tube can be used. For the soft tube, each flow path may be different in at least one of the flow path cross-sectional area, flow path length, flow path wall thickness, and constituent material. Due to this difference, the flow path resistance of each flow path may change. For example, at least one of the flow path cross-sectional area, flow path length, flow path wall thickness, and constituent material may be different in at least a part of the 2nd flow path 19c and the 3rd flow path 19d. Thus, the distribution ratio of the flow rate from the flow path connection portion 19e to the 2nd flow path 19c and the flow rate from the flow path connection portion 19e to the 3rd flow path 19d can be adjusted. Specifically, in order to make the flow path resistance of the 2nd flow path 19c smaller than that of the flow path 19d, for example, the flow path length of the 2nd flow path 19c can be made shorter than the flow path length of the flow path 19d. In addition, the thickness of the flow path wall of the second flow path 19c may be greater than the thickness of the flow path wall of the flow path 19d.

[0130] In addition, based on the above Figure 1A, the filter 11 and the concentrator 12 are respectively provided with the drain portion 82 and the drain portion 91, but the filter 11 and the concentrator 12 may also share a drain portion 82. For example, Figure 1D As shown in FIG. 1 , the second flow path 19 c may have a branch point 19 f and the fourth flow path 17 may be connected to the branch point. In addition, the fourth flow path 17 may have a backflow prevention portion 65 .

[0131] Figure 4H Show Figure 1D This is an example of the structure of the lower portion from the 0th flow channel 19a in the embodiment shown. Figure 4H The embodiment shown in the figure is different from the embodiment shown in the figure in that the second flow path 19c has a branch point 19f. Figure 4G The other structures are the same as in Figure 4G The structures described in are the same as those described in the previous section, and therefore, descriptions of the repeated parts are omitted.

[0132] Figure 4J Show Figure 1D This is a structural example of the fourth flow path 17 in the embodiment shown. Figure 4J The shape shown and Fig. 4I The difference between the illustrated embodiments is that the fourth flow path 17 is connected to the branch point 19f of the second flow path 19c instead of being connected to the drain portion 91.

[0133] exist Figure 4H and Figure 4J In the example shown, the fourth flow path 17 through which the drain of the concentrator passes is connected to the branch point 19f. Thus, the drain from the concentrator 12 can flow to the drain portion 82 via the flow path connection portion 19e. The connection port 84b, which is the end of the second flow path 19c, is open to the air before being connected to the first connection port 84a. The first connection port 84a is connected to a pressure gauge to measure the pressure in the second flow path.

[0134] And, use Figure 4K and Figure 4L 1 is a partial enlarged view of the flow path loop 20 of the processing system 1. Figure 4K The concentrator 12, the processed bag 13, the physiological saline bag 24, etc. are not connected to the flow circuit 20, and the connectors 21 connected to these components are connected to each other. Figure 4L The concentrator 12 , the processed bag 13 , and the like are connected to the flow circuit 20 .

[0135] in addition, Figure 4K 2 is a diagram showing a schematic structure of the flow path circuit 20. Figure 4LThis is a diagram showing a state where the flow path circuit 20 is installed on the guide panel 151. By installing the flow path 20 along the guide panel 151, the user can easily and accurately construct the flow path.

[0136] The flow path constituting the flow path loop 20 may have a connector 21 at each top end. In addition, the flow path constituting the flow path loop 20 may also have a mark 22 for clearly indicating the connection portion connected to the on-off valve (valve). Thus, it is easy to set the on-off valve (valve) at an appropriate position. In addition, the flow path constituting the flow path loop may be marked with a mark 23 such as a color for indicating the connection object connected to each device, filter, concentrator, etc. Thus, the user can easily confirm the connection object based on the mark 23.

[0137] In addition, the physiological saline bag 24 has a type connected with a needle and a type connected with a connector. Figure 4K In the embodiment, the flow path 25 may include both a needle 25a and a connector 25b at the top end so that both types can be connected. Figure 4E The structure shown is the same. A valve 25c may also be provided in the flow path 25.

[0138] The physiological saline bag 24 is connected to the flow path 25, and by driving the pump 51, the physiological saline can be supplied to the filter 11 through the flow paths 25 and 15. In this way, the filter 11 can be cleaned.

[0139] Figure 4L The flow circuit 20 shown has a tube 150 and a panel 151 that holds a portion of the tube 150 .

[0140] The tube 150 of the flow circuit 20 has softness and flexibility, and is made of, for example, transparent polyvinyl chloride.

[0141] The panel 151 is made of a hard resin or the like. The material of the panel 151 includes a resin containing any of ABS, PC (polycarbonate), PVC (polyvinyl chloride), PS (polystyrene), PP (polypropylene), POM (polyacetal), PE (polyethylene), PMMA (polymethyl methacrylate), SAN (styrene-acrylonitrile), and PA (polyamide). The panel 151 is formed into a substantially square thin plate by, for example, injection molding. The panel 151 has, for example, a 500 cm 2 The following plane area, preferably 400cm 2 The following floor area.

[0142] On the panel 151, the tube 150 of the flow path loop 20 is arranged along the panel surface. For example, on the panel 151, parts of the tube 150 such as the flow path 15, the flow path 16, the flow path 18 and the flow path 25 are arranged. The tube 150 protrudes outward from the peripheral portion R of multiple sides of the panel 151. It should be noted that in the present embodiment, the portion within 10 cm from the outer edge of the panel 151 is regarded as the peripheral portion R. The tube 150 protrudes outward from multiple locations of the panel 151, for example, more than 10 locations. The tube 150 protrudes outward from the panel 151 by more than 25 cm, preferably more than 35 cm. When the flow path loop 20 is transferred, the portions of the tube 150 protruding from the panel 151 may be bundled together.

[0143] The tube 150 of the flow path loop 20 is held at multiple locations of the panel 151. For example, the panel 151 is provided with a locking portion 160 in which the tube 150 is inserted from a direction along the panel surface and is locked by the locking portion 160, the locking portion 160 pressing the side surface of the tube 150 located in the front in the insertion direction; a pressing portion 161 pressing the side surface of the tube 150 locked in the locking portion 160 located in the rear in the insertion direction; and a groove portion 162 accommodating and holding the tube 150 locked in the locking portion 160 along the extension direction of the tube 150.

[0144] Since the tubes 150 of the flow circuit 20 protrude from the outer peripheral portion R of the panel 151 in multiple directions to the outside of the panel 151, it is possible to reduce the installation errors of each tube 150 with respect to the body fluid processing device 2. It should be noted that, when the tubes 150 of the flow circuit 20 protrude from the panel 151 in multiple directions to the outside, external force is likely to act on the tubes 150, but in such a case, by pressing the tubes 150 using the locking portion 160, the pressing portion 161 and the groove portion 162, it is possible to prevent the tubes 150 from falling off.

[0145] The tube 150 of the flow circuit 20 protrudes more than 25 cm to the outside from the panel 151, and the proportion of the portion of the tube 150 that is not fixed to the panel 151 becomes larger, and external force is easily applied to the tube 150. In this case, it is more effective to set the locking portion 160, the pressing portion 161 and the groove portion 162 on the outer peripheral portion R1 of the panel 151.

[0146] Since the plane area of ​​panel 151 is 500cm 2Since the panel 151 is small, the amount of material used for the panel 151 can be reduced, the panel 151 can be installed in a small device, and the packaging form can be made smaller. Here, even in the case of the panel 151 with a small plane area and the tube 150 of the flow circuit 20 is easy to fall off due to external force, by pressing the tube 150 using the locking portion 160, the pressing portion 161 and the groove portion 162, the tube 150 can be effectively prevented from falling off from the panel 151 without increasing the portion for holding the tube 150.

[0147] The preferred embodiment of the present invention is described above with reference to the accompanying drawings, but the present invention is not limited to this example. It is obvious that a person skilled in the art can think of various variations or modifications within the scope of the concept described in the claims, and the variations or modifications are of course considered to belong to the protection scope of the present invention.

[0148] 2. Connection check

[0149] Next, the connection check using the change in the pressure in the flow path will be described using a flowchart. Figure 3A This is an example of a flowchart showing a connection check.

[0150] In step S11, the control unit 86 increases the pressure of the liquid filled in the 0th flow path 19a by the pump 51 or the like while the valve 81 is closed. At this time, the second pressure measuring unit 88 may also detect the pressure of the liquid filled in the 0th flow path 19a.

[0151] In step S12, the control unit 86 controls the pressurizing unit 90 to open the valve 81, thereby transmitting pressure to the second flow path 19c. Alternatively, when the pressure acting on the liquid filled in the 0th flow path 19a measured by the second pressure measuring unit 88 exceeds a threshold value, the control unit 86 controls the pressurizing unit 90 to open the valve 81. At this time, the second pressure measuring unit 88 can detect a decrease in the flow path pressure of the 0th flow path 19a.

[0152] In step S13, the inspection unit 85 uses the first pressure measuring unit 87 to measure the change in the pressure in the second flow path 19c from the moment when the valve 81 is opened. Then, in step S14, the inspection unit 85 performs a connection inspection based on the change in the pressure in the second flow path 19c. For example, the inspection unit 85 can detect that the connection is established when the pressure in the flow path of the second flow path 19c increases or decreases by a predetermined value or more, or can detect that the connection is established when the maximum value of the pressure in the flow path of the second flow path 19c is a predetermined value or more.

[0153] Figure 3AAlthough the connection inspection is shown in the case where the pressure in the second flow path 19c is measured once, the pressure in the second flow path 19c may be measured a plurality of times during the connection inspection. Figure 3B 2 shows an example of a flow chart of the connection check in the case where the pressure in the second flow path 19 c is measured a plurality of times.

[0154] For example, during the connection check, the inspection unit 85 may perform multiple measurements of the flow path pressure of the second flow path 19c measured by the first pressure measuring unit 87 based on the pressurization of the 0th flow path 19a by the pressurizing unit 90 and / or perform multiple measurements of the difference in flow path pressure before and after pressurization of the second flow path 19c measured by the first pressure measuring unit 87, and determine based on the multiple measurement results that the second flow path 19c is connected to the first connection port 84a for the first pressure measurement.

[0155] In addition, during the connection check, the inspection unit 85 may change the pressurization pressure of the pressurization unit 90 and perform multiple confirmations on whether the second flow path 19c is connected to the first connection port 84a for measuring the first pressure. During the connection check, the inspection unit 85 determines that the second flow path 19c is connected to the first connection port 84a for measuring the first pressure based on the results of multiple confirmations.

[0156] Steps S21, S22, and S23 can be the same as steps S11, S12, and S13. Figure 3B In the flowchart shown, in step S24, the inspection unit 85 performs a connection inspection based on a change in the flow channel pressure of the second flow channel 19c, and terminates the process when it is determined that the connection is established.

[0157] On the other hand, when the inspection unit 85 determines that the connection is not made in step S24, the inspection unit 85 makes a connection determination based on the pressurization pressure in step S21 in step S25. Specifically, the inspection unit 85 can determine that the connection is not made when the pressurization pressure in step S21 is equal to or greater than a predetermined value. This is because, although the pressurization pressure in step S21 is equal to or greater than a predetermined value, the pressure in the flow path of the second flow path 19c does not change by a predetermined pressure, and thus it can be determined that the connection is not made.

[0158] In addition, when the inspection unit 85 determines that the pressurization pressure in step S21 is less than the predetermined value, the control unit 86 controls the pressurization unit 90 to further increase the pressure in the flow path of the 0th flow path 19a, and repeats steps S21, S22, S23, and S24. In this way, by increasing the pressure in the flow path of the 0th flow path 19a and repeating the connection inspection, there is a tendency to further improve the accuracy of the connection inspection.

[0159] It should be noted that the inspection unit 85 can detect the connection when the pressure in the second flow path 19c increases or decreases above a specified level, or can detect the connection when the maximum value of the pressure in the second flow path 19c is above a specified level.

[0160] By using the processing system as described above, the change in the pressure in the second flow path 19 c is detected, and it is possible to easily check whether the pressure measuring unit is connected.

[0161] Industrial Applicability

[0162] The treatment system of the present invention has industrial applicability as a treatment system for treating blood and / or body cavity fluid.

Claims

1. A processing system for processing blood and / or body cavity fluid, wherein: The processing system has: Filters; a pressurizing section, which includes a pump and a valve; A flow path connection portion; A 0th flow path, which connects the drain outlet of the filter and the valve; a first flow path connecting the valve and the flow path connecting portion; a second flow path connecting the flow path connection portion and a first connection port for measuring the first pressure; a third flow path connecting the flow path connection portion and a discharge portion storing the discharge liquid flowing out of the discharge outlet; an inspection unit that performs a connection inspection between the first connection port for measuring the first pressure and the second flow path; a first pressure measuring unit for measuring the pressure in the second flow path connected to the first connection port for measuring the first pressure; as well as a control unit that controls the pressurizing unit, The control unit controls the pressurizing unit so as to open the valve after pressurizing the liquid filled in the zero flow path in a state where the valve is closed. The inspection unit performs the connection inspection based on the flow channel internal pressure of the second flow channel pressurized by opening the valve, which is measured by the first pressure measuring unit.

2. The processing system according to claim 1, wherein: The first pressure measuring unit measures the flow channel pressure of the second flow channel based on a timing when the valve changes from a closed state to an open state.

3. The processing system according to claim 1, wherein: The third flow path is connected to the liquid discharge portion of the closed system.

4. The processing system according to claim 1, wherein: In the connection check, When the in-channel pressure of the second channel measured by the first pressure measuring unit is equal to or greater than a predetermined value, the inspection unit determines that the second channel is connected to the first connection port for measuring the first pressure.

5. The processing system according to claim 1, wherein: The inspection unit performs the connection inspection based on the flow channel internal pressure of the second flow channel before and after the pressurization measured by the first pressure measuring unit.

6. The processing system according to claim 1, wherein: In the connection check, The inspection unit determines that the second flow path is connected to the first connection port for first pressure measurement when a difference in flow path pressure before and after the pressurization of the second flow path measured by the first pressure measurement unit is equal to or larger than a predetermined value.

7. The processing system according to claim 1, wherein: In the connection check, The inspection unit measures the pressure within the second flow path measured by the first pressure measuring unit multiple times and / or measures the difference in pressure within the second flow path before and after pressurization measured by the first pressure measuring unit multiple times, and determines that the second flow path is connected to the first connection port for measuring the first pressure based on the multiple measurement results.

8. The processing system of claim 1, wherein: During the connection check, The inspection unit changes the pressurizing pressure of the pressurizing unit to check multiple times whether the second flow path is connected to the first connection port for measuring the first pressure. In the connection check, The inspection unit determines, based on the plurality of confirmation results, that the second flow path is connected to the first connection port for measuring the first pressure.

9. The processing system of claim 1, wherein: At least one of a flow path cross-sectional area, a flow path length, a flow path wall thickness, and a constituent material is different in at least a portion of the second flow path and the third flow path.

10. The processing system of claim 1, wherein: Gas is sealed in a portion of the second flow path.

11. The processing system of claim 1, wherein: The pressurizing unit includes a second pressure measuring unit for measuring pressurizing pressure.

12. The processing system of claim 1, wherein: The processing system has: a concentrator connected directly or indirectly to the filter; a fourth flow path for discharging the effluent removed by the concentrator; a backflow prevention unit provided in the fourth flow path; and a branch point provided in the second flow path, The fourth flow path is connected to the branch point.

13. The processing system of claim 1, wherein: The processing system further includes an output unit for displaying a result of the connection check.

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