A traditional Chinese medicine pill for treating stomach diseases and its preparation method

Abstract

The present invention discloses a traditional Chinese medicine pill for treating stomach diseases and its preparation method, which relates to the technical field of traditional Chinese medicine. The active ingredients of the traditional Chinese medicine pill for treating stomach diseases include a traditional Chinese medicine composition; the traditional Chinese medicine composition includes the following components in parts by weight: 25-35 parts of bamboo shavings processed with ginger, 20-30 parts of prepared pinellia, 15-25 parts of equisetum pratense, 8-15 parts of scutellaria baicalensis, 6-10 parts of Corydalis yanhusuo, 5-15 parts of germinated barley, 3-8 parts of glutinous millet, 2-8 parts of zanthoxylum nitidum, 3-5 parts of halloysite, and 2-8 parts of rabdosia serra. The traditional Chinese medicine pill provided by the present invention has a good improvement effect on the gastric mucosal injury, submucosal hemorrhage and congestion caused by bile reflux, and has a good therapeutic effect on the inflammatory injury of the gastric mucosa.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine pill for treating stomach diseases and a preparation method thereof. Background Art

[0002] Bile reflux gastritis (BRG), also known as alkaline reflux gastritis, refers to the condition where duodenal contents such as bile and pancreatic juice flow into the stomach due to reasons such as dysfunction of the pyloric sphincter or gastric pylorus surgery, causing inflammation, erosion, and bleeding of the gastric mucosa, weakening the barrier function of the gastric mucosa, and leading to increased diffusion of H + resulting in chronic lesions of the gastric mucosa, with the main clinical manifestations being recurrent upper abdominal pain, a burning sensation in the stomach, acid reflux, nausea, vomiting, bitter taste and bad breath in the mouth, loss of appetite, etc. If the condition is not controlled in a timely manner, the gastric mucosal damage will worsen, and intestinal metaplasia, atrophy, and even canceration may occur.

[0003] The pathogenesis of bile reflux gastritis is complex and is mainly related to biliary diseases, gastrointestinal hormones, gastric acid secretion, Helicobacter pylori (Hp) infection, diet and lifestyle, mental and psychological factors, etc. Currently, Western medicine mostly adopts symptomatic treatment, and the commonly used drugs include bile acid-neutralizing drugs, gastrointestinal motility-enhancing drugs, acid-suppressing drugs, gastric mucosal protectants, cholagogic drugs, anti-Hp drugs, anti-anxiety and antidepressant drugs, etc. However, the above-mentioned schemes can only improve the symptoms of patients to a certain extent, have a long treatment cycle, are prone to recurrence after drug withdrawal, and have obvious side effects, thus affecting the compliance and efficacy of patients.

[0004] Traditional Chinese medicine has the advantages of definite clinical efficacy, relatively safe medication, flexible service methods, relatively low cost, huge innovation potential, and broad development space. Therefore, it is very necessary to develop traditional Chinese medicine for treating bile reflux gastritis. Summary of the Invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine pill for treating stomach diseases and a preparation method thereof to solve the problems existing in the above-mentioned prior art. This traditional Chinese medicine pill has a good improvement effect on gastric mucosal damage, submucosal hemorrhage, and congestion caused by bile reflux, and has a good therapeutic effect on inflammatory damage of the gastric mucosa.

[0006] To achieve the above purpose, the present invention provides the following scheme:

[0007] The present invention provides a traditional Chinese medicine composition for treating stomach diseases, comprising the following components in parts by weight: 25-35 parts of bamboo shavings processed with fresh ginger, 20-30 parts of pinellia ternata processed with rhizoma zingiberis recens, 15-25 parts of equisetum pratense, 8-15 parts of scutellaria baicalensis, 6-10 parts of Corydalis yanhusuo, 5-15 parts of sprouted barley, 3-8 parts of glutinous millet, 2-8 parts of zanthoxylum nitidum, 3-5 parts of halloysite, and 2-8 parts of herba lysimachiae.

[0008] The gastric disease is bile reflux gastritis.

[0009] Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 30 parts of bamboo shavings processed with fresh ginger, 25 parts of pinellia ternata processed with lime, 20 parts of equisetum pratense, 10 parts of scutellaria baicalensis, 8 parts of Corydalis yanhusuo, 10 parts of sprouted millet, 5 parts of glutinous rice, 5 parts of zanthoxylum nitidum, 5 parts of halloysitum rubrum and 5 parts of rabdosia serra.

[0010] The present invention also provides an application of the above traditional Chinese medicine composition in the preparation of a medicament for treating gastric diseases, wherein the gastric disease is bile reflux gastritis.

[0011] The present invention also provides a traditional Chinese medicine pill for treating gastric diseases, and the active ingredient comprises the above traditional Chinese medicine composition;

[0012] The gastric disease is bile reflux gastritis.

[0013] Furthermore, the traditional Chinese medicine pill for treating gastric diseases further comprises pharmaceutically acceptable excipients.

[0014] Furthermore, the excipients include honey.

[0015] Furthermore, the mass ratio of the traditional Chinese medicine composition to the honey is 2:1.

[0016] The present invention also provides a preparation method of the above traditional Chinese medicine pill for treating gastric diseases, comprising the following steps:

[0017] Weigh and prepare each raw material according to the raw material formula, roll them into fine powder together, mix evenly, and sieve to obtain a mixed medicinal powder;

[0018] Mix the mixed medicinal powder with honey evenly to prepare the traditional Chinese medicine pill for treating gastric diseases.

[0019] Furthermore, the sieving step uses a sieve with 80-100 meshes.

[0020] Furthermore, the mass ratio of the mixed medicinal powder to the honey is 2:1.

[0021] Bamboo shavings are the dried middle layer of the stems of Bambusa tuldoides Munro, Sinocalamus beecheyanus (Munro) McClure var. pubescens P. F. Li or Phyllostachys nigra (Lodd.) Munro var. henonis (Mitf.) Stapf ex Rendle. Processed bamboo shavings with fresh ginger are bamboo shavings that are evenly mixed with fresh ginger juice and then fried until yellow. Its medicinal properties are sweet and slightly cold, and it belongs to the lung and stomach meridians. Clinically, it has the effects of clearing heat and resolving phlegm, and removing vexation and stopping vomiting.

[0022] Processed pinellia ternata is the processed product of pinellia ternata. Its medicinal properties are pungent and warm; it belongs to the spleen, stomach and lung meridians; it has the effect of drying dampness and resolving phlegm.

[0023] Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi; its medicinal properties are bitter and cold; it belongs to the lung, gallbladder, spleen, large intestine and small intestine meridians; it has the functions of clearing heat and drying dampness, and purging fire and detoxifying.

[0024] Equisetum pratense Ehrh. is a medium-sized fern belonging to the genus Equisetum of the family Equisetaceae. It is bitter in taste and has a neutral property. It has the effects of promoting blood circulation, diuresis, expelling worms, reducing blood pressure, and calming and analgesic.

[0025] Rabdosia serra (Maxim.) Hara and Rabdosia lophanthoides (Buch.-Ham.) Hara var. gerardiana (Wall.) Hara are the dried whole herbs of the plant Rabdosia serra (Maxim.) Hara of the family Labiatae. They are bitter in taste and have a cold property. They belong to the liver, gallbladder, and large intestine meridians. They have the effects of clearing heat and detoxifying, promoting diuresis and reducing jaundice, and dispersing stasis and detumescence.

[0026] Rhizoma Corydalis is the dried tuber of the plant Corydalis yanhusuo W. T. Wang of the family Papaveraceae. It is pungent and bitter in taste and has a warm property. It belongs to the liver and spleen meridians. Its main effects are promoting blood circulation, promoting qi movement, and relieving pain.

[0027] Fructus Setariae Germinatus is the processed product of the mature fruit of the plant Setaria italica (L.) Beauv. of the family Gramineae after germination and drying. It is sweet in taste and has a neutral property. It belongs to the spleen and stomach meridians. It has the effects of promoting digestion and regulating the middle energizer, and strengthening the spleen and promoting appetite.

[0028] Glutinous Millet is the sticky seed of the plant Setaria italica (L.) Beauv. or Setaria italica (L.) Beauv. var. germanica (Mill.) Schrad. of the family Gramineae. It is sweet in taste and has a slightly cold property. It belongs to the lung, stomach, and large intestine meridians. It has the effects of dispelling wind and dampness, regulating the stomach and calming the mind, and detoxifying and astringing sores.

[0029] Radix Zanthoxyli Nitidi is the dried root of the plant Zanthoxylum nitidum (Roxb.) DC. of the family Rutaceae. It is bitter and pungent in taste and has a neutral property. It belongs to the liver and stomach meridians. It has the effects of promoting blood circulation to remove stasis, promoting qi movement to relieve pain, expelling wind and dredging collaterals, and detoxifying and detumescence.

[0030] Halloysitum Rubrum is a silicate mineral of the halloysite group of halloysite. Its main effects are astringing the intestine, stopping bleeding, and promoting granulation and healing sores.

[0031] The present invention discloses the following technical effects:

[0032] The present invention has developed a traditional Chinese medicine composition for treating bile reflux gastritis. It uses bamboo shavings processed with ginger, pinellia ternata processed with rhizoma zingiberis recens, and Equisetum pratense Ehrh. as the monarch drugs to clear the gallbladder and stomach, balance the ascending and descending, relieve pain and promote blood circulation; uses scutellaria baicalensis georgi and Rhizoma Corydalis as the ministerial drugs to soothe the liver and gallbladder; uses Fructus Setariae Germinatus and Glutinous Millet as the adjuvant drugs to promote appetite and regulate the middle energizer, and uses Radix Zanthoxyli Nitidi, Halloysitum Rubrum, and Rabdosia serra (Maxim.) Hara as the messenger drugs to clear heat and detoxify, promote diuresis and benefit qi. All the drugs are used in combination with cold and warm properties to achieve the effect of harmonizing the stomach and reducing adverse qi.

[0033] The traditional Chinese medicine composition provided by the present invention has a good improvement effect on gastric mucosal damage, submucosal hemorrhage, and congestion caused by bile reflux, and has a good therapeutic effect on inflammatory damage of the gastric mucosa. Detailed implementation mode

[0034] The various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be construed as a limitation on the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0035] It should be understood that the terms used in the present invention are only for describing particular embodiments and are not intended to limit the present invention. Additionally, for the numerical ranges in the present invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any intermediate value within any stated value or stated range, as well as each smaller range between any other stated value or intermediate value within the stated range, is also included in the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0036] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by a person of ordinary skill in the art to which the present invention pertains. Although the present invention only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0037] Without departing from the scope or spirit of the present invention, various improvements and changes can be made to the specific embodiments of the present invention specification, which are obvious to those skilled in the art. Other embodiments obtained from the present invention specification are also obvious to those skilled in the art. The present invention specification and examples are merely exemplary.

[0038] Regarding the use of "comprising", "including", "having", "containing", etc. herein, they are all open-ended terms, meaning including but not limited to.

[0039] Example 1

[0040] Raw material formula of traditional Chinese medicine composition: 25 g of bamboo shavings processed with ginger, 30 g of prepared pinellia, 15 g of equisetum pratense, 15 g of scutellaria baicalensis, 10 g of Corydalis yanhusuo, 15 g of germinated barley, 8 g of job's tears, 8 g of zanthoxylum nitidum, 3 g of halloysite, and 8 g of rabdosia serra.

[0041] Preparation method of traditional Chinese medicine pills:

[0042] According to the above raw material formula, weigh and mix all the raw materials, roll them into fine powder together, mix evenly, and pass through a 100-mesh sieve to obtain a mixed medicinal powder; mix the mixed medicinal powder with honey in a mass ratio of 2:1 evenly to make traditional Chinese medicine pills of 2 g per pill.

[0043] Example 2

[0044] Raw material formula of traditional Chinese medicine composition: 30 g of bamboo shavings processed with ginger, 25 g of pinellia processed with lime, 20 g of equisetum pratense, 10 g of scutellaria baicalensis, 8 g of Corydalis yanhusuo, 10 g of germinated barley, 5 g of glutinous millet, 5 g of zanthoxylum nitidum, 5 g of halloysite, and 5 g of Rabdosia serra.

[0045] Preparation method of traditional Chinese medicine pills:

[0046] According to the above raw material formula, weigh and mix all the raw materials, roll them into fine powder together, mix evenly, and sieve through a 100-mesh sieve to obtain the mixed medicinal powder; mix the mixed medicinal powder with honey in a mass ratio of 2:1 evenly to make traditional Chinese medicine pills of 2 g per pill.

[0047] Example 3

[0048] Raw material formula of traditional Chinese medicine composition: 35 g of bamboo shavings processed with ginger, 20 g of pinellia processed with lime, 25 g of equisetum pratense, 8 g of scutellaria baicalensis, 6 g of Corydalis yanhusuo, 5 g of germinated barley, 3 g of glutinous millet, 2 g of zanthoxylum nitidum, 5 g of halloysite, and 2 g of Rabdosia serra.

[0049] Preparation method of traditional Chinese medicine pills:

[0050] According to the above raw material formula, weigh and mix all the raw materials, roll them into fine powder together, mix evenly, and sieve through a 100-mesh sieve to obtain the mixed medicinal powder; mix the mixed medicinal powder with honey in a mass ratio of 2:1 evenly to make traditional Chinese medicine pills of 2 g per pill.

[0051] Comparative Example 1

[0052] Same as Example 2, the only difference is that bamboo shavings processed with ginger are replaced with raw bamboo shavings.

[0053] Comparative Example 2

[0054] Same as Example 2, the only difference is that pinellia processed with lime is replaced with raw pinellia.

[0055] Comparative Example 3

[0056] Same as Example 2, the only difference is that pinellia processed with lime is replaced with pinellia processed with ginger.

[0057] Effect Verification Example 1

[0058] 1. Experimental animals

[0059] KM mice, SPF grade, body weight (20 ± 1.5) g, half male and half female.

[0060] 2. Construction of animal model

[0061] Give the mice intragastric administration on an empty stomach with reflux fluid once a day, with a dose of 20 mL / kg each time, and continuously intragastric administration for 45 days to construct bile reflux gastritis model mice.

[0062] Method for preparing reflux fluid: Dissolve 2.5 g of sodium taurocholate, 1.5 g of pancreatin, and 0.25 g of lecithin in 100 mL of normal saline, stir well and mix evenly to obtain the reflux fluid.

[0063] 3. Experimental grouping

[0064] Take 60 mice with bile reflux gastritis model, randomly divide them into 6 groups, with 10 mice in each group. Each group was given intragastric administration according to Table 1 once a day for 30 days. At the same time, healthy KM mice were used as blank control.

[0065] Table 1 Experimental grouping

[0066]

[0067]

[0068] 4. Index detection

[0069] After the last administration, fast for 24 h, take 2 mL of blood from the abdominal aorta, centrifuge to obtain serum, and use ELISA kit to measure the contents of interleukin-8 (IL-8), tumor necrosis factor (TNF-α), and serum gastrin (GAS) in the serum. At the same time, take gastric tissue to detect epinephrine E 2 (PGE 2 ) content.

[0070] 5. Experimental results

[0071] (1) Detection results of serum IL-8, TNF-α, and GAS contents

[0072] The detection results of serum IL-8, TNF-α, and GAS contents in each group are shown in Table 2. Compared with the blank control group, the serum IL-8 and TNF-α in the model group mice were significantly increased (P < 0.01); the serum IL-8 and TNF-α contents in the A1 group mice were significantly lower than those in the model group (P < 0.01); the reduction of serum IL-8 and TNF-α contents in the A2 - A4 group mice was not obvious.

[0073] GAS is an important gastrointestinal hormone secreted by G cells, which can promote the secretory function of the gastrointestinal tract, promote the contraction of the gastric antrum and gastric body, increase the motility of the gastrointestinal tract, and at the same time promote the contraction of the pyloric sphincter, reduce reflux, and play an important role in aspects such as gastric acid secretion and mucosal protection. Compared with the model group, the GAS content in the A1 group was significantly increased (P < 0.01); the increase of GAS content in the A2 - A4 group was not obvious.

[0074] Table 2 Detection results of serum IL-8, TNF-α, and GAS contents in each group

[0075] Group IL-8 content (ng / L) TNF-α (ng / L) GAS (ng / L) Blank control group 71.2±3.64 70.3±6.42 221.0±7.25 Model group <![CDATA[119.4±5.17 ** > <![CDATA[157.8±8.24 ** > <![CDATA[170.4±5.38 ** > A1 <![CDATA[68.1±3.41 ## > <![CDATA[92.4±5.67 ## > <![CDATA[189.2±6.08 ## > A2 <![CDATA[94.5±2.08 # > <![CDATA[123.5±6.27 # > <![CDATA[180.7±5.90 # > A3 <![CDATA[96.7±3.91 # > <![CDATA[118.4±4.91 ## > 178.2±5.93 A4 115.2±4.38 <![CDATA[127.2±8.24 # > 174.2±8.34 Positive control group <![CDATA[95.6±4.29 # > <![CDATA[93.2±6.01 ## > <![CDATA[200.6±4.19 ## >

[0076] Note: Compared with the blank control group, ** P < 0.01; compared with the model group, # P < 0.05, ## P < 0.01.

[0077] (2) Detection results of PGE content in gastric tissue 2 content

[0078] PGE 2 is a physiological protective substance, which has the functions of improving the gastric mucus barrier function, increasing the blood supply of the gastric mucosa, nourishing and protecting epithelial cells, reducing inflammatory reactions, and promoting the self-repair of the gastric mucosa. The detection results of PGE content in gastric tissues of each group are shown in Table 3. Compared with the model group, the PGE content in group A1 was significantly increased (P < 0.01); the increase in PGE content in groups A2 - A4 was not obvious. 2 content 2 content (P < 0.01); the increase in PGE content in groups A2 - A4 was not obvious. 2 content

[0079] Table 3 Detection results of PGE content in gastric tissues of each group 2 content

[0080] Group <![CDATA[PGE 2 Content (ng / L)]]> Blank control group 389.1±15.46 Model group <![CDATA[305.8±9.87 ** > A1 <![CDATA[364.7±8.16 ## > A2 <![CDATA[321.2±13.58 # > A3 308.9±11.22 A4 315.2±18.34 Positive control group <![CDATA[346.3±7.08 # >

[0081] Note: Compared with the blank control group, ** P < 0.01; compared with the model group, # P < 0.05, ## P < 0.01.

[0082] In summary, the present invention uses a mouse model of bile reflux gastritis to verify the therapeutic effect of the traditional Chinese medicine pill prepared by the present invention on bile reflux gastritis. The results show that the traditional Chinese medicine pill prepared by the present invention can significantly increase the PGE content in the tissues of mice with bile reflux gastritis and the GAS content in the serum, and reduce the IL-8 and TNF-α contents in the serum. Processing is an important technique in the process of traditional Chinese medicine pharmaceutical. By processing, the properties and efficacy of medicinal materials can be changed. The traditional Chinese medicine pill prepared by the present invention through the compatibility of special processed products with other medicinal flavors can play a good therapeutic and protective role on the stomach. 2 content

[0083] Effect verification example 2

[0084] 1. Materials and methods

[0085] 1.1 General information

[0086] A total of 80 patients with bile reflux gastritis who were treated in the Affiliated Hospital of Nanjing University of Chinese Medicine from February 2023 to December 2023 were selected as the research objects.

[0087] Inclusion criteria: (1) Meeting the diagnostic criteria of the "Expert Consensus on the Diagnosis and Treatment of Chronic Gastritis in Traditional Chinese Medicine (2017 Edition)". (2) Being clearly diagnosed with reflux gastritis by gastroscopy. (3) Aged between 20 and 65 years old. (4) Not having taken drugs such as gastric mucosal protectants, acid suppressants, and gastric motility drugs recently.

[0088] Exclusion criteria: (1) Not meeting the Western medicine and traditional Chinese medicine diagnostic criteria for bile reflux gastritis; (2) Those with positive Hp; (3) Needing to exclude bile reflux caused by improper gastroscopy operation; (4) Having taken any drugs that affect the research results recently; (5) Having other digestive system diseases, metabolic diseases, tumors, or mental diseases; (6) Being allergic to the drugs related to this study; (7) Women who are pregnant, in the pregnancy preparation period, or in the lactation period; (8) Currently participating in other drug clinical studies. Exclusion criteria: (1) Those with misdiagnosis or mis-inclusion; (2) Patients with poor compliance, not taking drugs according to the requirements or stopping taking drugs midway; (3) Having serious adverse reactions or complications midway; (4) Having to terminate this study due to various irresistible factors during the process.

[0089] 1.2 Efficacy determination

[0090] Comprehensive evaluation was carried out with reference to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines" and the gastroscopy examination results before and after the treatment of patients.

[0091] Cure: All clinical symptoms and signs of the patient completely disappeared, the mucosa was seen to return to normal under gastroscopy, and there was no bile reflux.

[0092] Marked effect: The patient's symptoms improved significantly (the symptoms were significantly reduced or the attack frequency was significantly decreased), the signs were significantly alleviated, the gastroscopy examination showed that the mucosa basically returned to normal, and the bile reflux basically disappeared.

[0093] Effective: The patient's symptoms improved (the symptoms were milder or the attack frequency was decreased), the signs were alleviated, the gastroscopy examination showed that the gastric mucosa improved somewhat, and the bile reflux was reduced.

[0094] Ineffective: Not meeting the above criteria.

[0095] 1.3 Experimental grouping and treatment methods

[0096] 80 patients were randomly and evenly divided into two groups. One group was the treatment group, taking the traditional Chinese medicine pills prepared in Example 2 2.5 g each time, twice a day in the morning and evening, for 4 consecutive weeks; the other group was the control group, taking hydrotalcite and domperidone three times a day, with hydrotalcite 1 g each time and domperidone 10 mg each time.

[0097] 2. Results

[0098] The statistical results of the curative effects of the two experimental groups are shown in Table 4. The results show that the total effective rate of the treatment group is significantly higher than that of the control group. The traditional Chinese medicine pills prepared by the present invention have good improvement effects on the gastric mucosal damage, submucosal hemorrhage and congestion caused by bile reflux, and have good therapeutic effects on the inflammatory damage of the gastric mucosa.

[0099] Half a year after the end of the treatment, all patients were followed up. The recurrence rates of the treatment group and the control group were 7.5% and 36.8% respectively. Thus, it can be seen that the long-term effect of the treatment group is better than that of the control group.

[0100] Table 4 Statistical results of the curative effects of the treatment group and the control group

[0101]

[0102] The embodiments described above are only descriptions of the preferred embodiments of the present invention, and do not limit the scope of the present invention. Without departing from the design spirit of the present invention, various deformations and improvements made by those of ordinary skill in the art to the technical solutions of the present invention shall fall within the protection scope determined by the claims of the present invention.

Claims

1. A Chinese medicine composition for treating gastropathy, characterized in that: The invention is composed of the following components in parts by weight: 25-35 parts of ginger bamboo shavings, 20-30 parts of French pinellia tuber, 15-25 parts of equisetum arvense, 8-15 parts of scutellaria baicalensis, 6-10 parts of corydalis, 5-15 parts of malt sprout, 3-8 parts of millet, 2-8 parts of dahliae, 3-5 parts of red ochre and 2-8 parts of cyperus rotundus. The gastric disease is bile reflux gastritis.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition consists of the following components in parts by weight: 30 parts of ginger bamboo shavings, 25 parts of French pinellia, 20 parts of horsetail, 10 parts of scutellaria, 8 parts of corydalis, 10 parts of malt sprout, 5 parts of sorghum, 5 parts of zelkova, 5 parts of red ochre and 5 parts of rhizoma scutellariae.

3. Use of the Chinese medicine composition according to claim 1 or 2 in preparing a medicine for treating gastric disease, characterized in that: The gastric disease is bile reflux gastritis.

4. A Chinese medicine pill for treating gastric disease, characterized in that: The active ingredient comprises the Chinese medicine composition according to claim 1 or 2; The gastric disease is bile reflux gastritis.

5. The Chinese medicine pill for treating gastric disease according to claim 4, characterized in that: The Chinese medicine pills for treating gastric diseases also include pharmaceutically acceptable excipients.

6. The Chinese medicine pill for treating gastric disease according to claim 5, characterized in that: The auxiliary material includes honey.

7. The Chinese medicine pill for treating gastric disease according to claim 6, characterized in that: The mass ratio of the traditional Chinese medicine composition to the honey is 2:

1.

8. A method for preparing the Chinese medicine pills for treating gastric disease as claimed in claim 4, characterized in that: The following steps are involved: According to the raw material formula, all raw materials are weighed and mixed, rolled into fine powder, mixed evenly, sieved, and mixed powder is obtained; The mixed medicine powder and honey are evenly mixed to prepare the Chinese medicine pills for treating gastric disease.

9. The preparation method according to claim 8, characterized in that: The sieving step uses a 80-100 mesh sieve.

10. The preparation method according to claim 8, characterized in that: The mass ratio of the mixed medicinal powder to the honey is 2:1.

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