Solid beverage for eradicating chloasma and preparation method thereof

Abstract

The invention provides a chloasma eradication solid beverage and a preparation method thereof, the chloasma eradication solid beverage comprises a wild jujube extract, a wild vitis amurensis extract and a wild malus baccata extract, and the extract components comprise pidoxine, resveratrol, procyanidine, catechin, syringic acid, anthocyanin, ferulic acid, gallic acid, vitis amurensis alcohol and chlorogenic acid. The main components of the adopted raw materials are fresh and high-quality wild jujube, wild vitis amurensis and wild malus baccata, and the wild jujube, the wild vitis amurensis and the wild malus baccata can be used for extracting various polyphenol compounds similar to resveratrol and vitamin effective components such as vitamin B6. Through reasonable compatibility and processing, the effects of resisting oxidation, resisting inflammation, improving blood circulation, improving overall health and the like are achieved, the effect of relieving and even eliminating chloasma is achieved by playing a role in the interior of the body, the method does not need skin breaking operation, the recurrence rate of chloasma can be reduced and eradicated after long-term use, the side effect is small, and the effect is definite.

Description

Technical Field

[0001] The invention belongs to the technical field of health beverages, and in particular relates to a chloasma-eliminating solid beverage and a preparation method thereof. Background Art

[0002] Melasma is recognized as the king of spots in the medical skin care industry. Its pathogenesis is complex, mainly including oxidative stress, hormone secretion, negative emotions leading to liver qi stagnation and blood stasis on the face, and poor blood circulation on the face slows down facial metabolism, pigmentation in the basal layer of the epidermis, and ultraviolet radiation stimulates excessive deposition of melanocytes in the skin. At present, domestic and foreign solutions for removing chloasma and lightening spots include: medical beauty projects such as Israeli picosecond laser, oral Chinese medicine, facial masks, long-term skin care in the hospital, etc.

[0003] However, medical beauty projects such as Israel's ultra-picosecond laser, which charges according to the area of ​​the spots, make the overall treatment cost high, and the skin-breaking operation causes damage to the skin, with a long recovery period and a high recurrence rate. Oral Chinese medicine, facial masks, and long-term skin care maintenance are too burdensome and slow to take effect. These solutions are time- and economically costly for consumers. Moreover, chloasma is distributed in deep layers. Currently, there is basically no solution that can completely remove facial chloasma. Even if there are drugs like hydroquinone cream that can remove chloasma by depigmenting the skin melanin, it will produce large side effects. In summary, a new technical solution needs to be developed to improve it. Summary of the invention

[0004] In view of the problems in the above-mentioned prior art, the present invention provides a composition and a solid beverage with the effect of removing chloasma and lightening spots, and a preparation method thereof. Through the reasonable combination and processing of the raw materials, the chloasma can be reduced or even eliminated, thereby achieving the purpose of removing spots. No skin breaking operation is required. Long-term use can reduce or eliminate the recurrence rate of chloasma. It has few side effects, good taste and clear effects.

[0005] The present invention is implemented through the following technical scheme: a solid beverage for eliminating chloasma, characterized in that it includes wild round jujube fruit extract, wild wild grape extract, and wild hawthorn fruit extract, and the components of the extract contain: pyridoxine, resveratrol, proanthocyanidins, catechins, syringic acid, anthocyanidins, ferulic acid, gallic acid, grape alcohol, and chlorogenic acid.

[0006] The present invention also includes a method for preparing a solid beverage for eliminating chloasma, which comprises the following steps in sequence: S1. The production process of wild round jujube powder, wild wild grape powder and wild hawthorn powder: wild round jujube, wild wild grape and wild hawthorn are selected within three days of picking, and the wild round jujube, wild wild grape and wild hawthorn are washed with running water to remove the mud and dirt on the surface of the fruit, rinsed with distilled water, soaked with ethanol solution, and then rinsed with sterilized distilled water, and dried with sterile filter paper, and the wild round jujube, wild wild grape and the wild hawthorn are cut into thin slices, and the slices are introduced into a mortar below room temperature, and liquid nitrogen is poured in, and the slices are ground into powder, and sieved to obtain medium-sized wild round jujube powder, the wild wild grape powder and the wild hawthorn powder; S2. using a heavy percolation extraction method to obtain a crude extract of wild jujube, a crude extract of wild hawthorn, and a crude extract of wild wild grape, wherein a 55% to 75% ethanol solution is added to a percolation cylinder containing wild wild grape powder, a 55% to 80% ethanol solution is added to a percolation cylinder containing wild jujube powder, and a 35% to 60% ethanol solution is added to a percolation cylinder containing wild hawthorn powder; S3. The crude extract of wild round jujube, wild hawthorn, and wild wild grape obtained in step S2 is centrifuged at a high speed, the supernatants are combined, and then filtered through an ultrafiltration membrane, the filtrate is placed in a low-temperature freezer for freezing treatment, and then dehydrated by a vacuum dryer to obtain dried round jujube purified powder, wild hawthorn purified powder, and wild wild grape purified powder; S4. sterilize the powder obtained in step S3 by ionizing radiation, fully mix the sterilized wild jujube purified powder, wild hawthorn purified powder, and wild grape purified powder with a thickener, grind the mixed powder product, dry it in a vacuum dryer to obtain a mixed powder product, sieve the mixed powder product through a sieve to obtain a powder product with uniform coarseness and fineness, and finally package it.

[0007] The raw materials of the solid beverage composition are as follows: 10 to 14 parts of wild round jujube; 8 to 13 parts of wild wild grape; 6 to 9 parts of wild hawthorn; Furthermore, the specific operation of the percolation method in step S2 is: The powder raw materials are evenly placed in three percolation cylinders, each of which is arranged in series. The percolation cylinders are No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder in order. The weight ratio of the powder raw materials in No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder is 4:2:1. The amount of ethanol added to each percolation cylinder is to completely soak the material, and the air in the percolation cylinder is exhausted. Soak for 24 to 48 hours, shake regularly, and flow out at 1 to 3 ml / min per kilogram of material; 1 / 2 of the primary filter liquid A is collected in the No. 1 percolation cylinder and stored in another container, the remaining 1 / 2 of the subsequent filter liquid A is introduced into the No. 2 percolation cylinder, 1 / 2 of the primary filter liquid B is collected and stored in another container, the remaining 1 / 2 of the subsequent filter liquid B is introduced into the No. 3 percolation cylinder, all the primary filter liquid C is collected, the primary filter liquid A, the primary filter liquid B and the primary filter liquid C are mixed to obtain a crude extract, and in this way, a crude extract of wild round jujube, a crude extract of wild hawthorn and a crude extract of wild wild grape are obtained respectively.

[0008] Furthermore, the ultrafiltration membrane is made of a polymer material such as polysulfone, polyethersulfone, polyacrylonitrile, polyvinyl chloride, etc., and its molecular retention capacity is 500 to 20KDa; Furthermore, the thickener is xanthan gum, accounting for 1% of the total mass.

[0009] The invention has the following advantages: the raw materials used in the invention are mainly fresh and high-quality wild jujube, wild wild grape and wild hawthorn, so that the solid beverage with the raw materials as the main ingredients does not need to add too much sweetener, acidulant and spices to help increase appetite, and the wild jujube, wild wild grape and wild hawthorn can be extracted to contain a variety of polyphenol compounds such as resveratrol, and the effects of anti-oxidation, anti-inflammation, improving blood circulation, improving overall health, etc. can be achieved through reasonable compatibility and processing, and the effects of the internal organs of the human body can be exerted to reduce chloasma, and even eliminate and exterminate chloasma. The method does not require skin breaking operation, and long-term use can reduce and eliminate the recurrence rate of chloasma, with small side effects and clear effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 A process flow chart of an embodiment of the present invention; Figure 2 This is a photo of the finished powder of one embodiment of the present invention; Figure 3 This is a facial state diagram (side face) of a patient with chloasma according to an embodiment of the present invention; Figure 4 This is a facial state diagram (front face) of a patient with chloasma according to an embodiment of the present invention; Figure 5 FIG. 4 is a diagram of the facial state after healing according to an embodiment of the present invention. DETAILED DESCRIPTION

[0011] The following further describes the implementation of the present invention in detail with reference to the accompanying drawings and examples. Embodiment 1

[0012] A solid beverage for eliminating chloasma, comprising wild round jujube fruit extract, wild wild grape extract, and wild hawthorn fruit extract, wherein the extract contains: pyridoxine, resveratrol, proanthocyanidins, catechins, syringic acid, anthocyanidins, ferulic acid, gallic acid, grape alcohol, and chlorogenic acid. Figure 1 As shown, the method for preparing the solid beverage comprises the following steps in sequence: (1) The production process of wild jujube powder, wild wild grape powder and wild hawthorn powder is as follows: 12 parts of wild jujubes, 10 parts of wild wild grapes and 8 parts of wild hawthorns picked within three days are selected, and rotten fruits are screened out; the wild jujubes, wild wild grapes and wild hawthorns are washed with running water to remove mud and dirt on the surface of the fruits, rinsed with distilled water twice, soaked with 75% ethanol solution for 30 seconds, and then rinsed with sterile distilled water twice, and dried with sterile filter paper; the wild jujubes, wild wild grapes and wild hawthorns are cut into thin slices, and the slices are introduced into a mortar precooled with -196°C liquid nitrogen, and -196°C liquid nitrogen is poured in small amounts and multiple times. During the grinding process, the liquid nitrogen should be prevented from drying up, and the powder is quickly ground into powder, and sieved to obtain medium-specification wild jujube powder, wild wild grape powder and wild hawthorn powder, wherein the medium-specification powder is powder that can pass through the No. 4 sieve but is mixed with powder that can pass through the No. 5 sieve and does not exceed 60%; (2) Extraction of solid beverage composition: A crude extract of wild jujube, a crude extract of wild hawthorn, and a crude extract of wild grape are obtained by heavy percolation extraction, wherein a 70% ethanol solution is added to a percolation cylinder containing wild grape powder, a 60% ethanol solution is added to a percolation cylinder containing wild jujube powder, and a 50% ethanol solution is added to a percolation cylinder containing wild hawthorn powder. The specific operation is as follows; The powder raw materials are evenly placed in three percolation cylinders, each of which is arranged in series. The percolation cylinders are No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder in order. The weight ratio of the powder raw materials in No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder is 4:2:1. The amount of ethanol added to each percolation cylinder is to completely soak the material, and the air in the percolation cylinder is exhausted. Soak for 36 hours, shake regularly, and flow out at 2 ml / min per kilogram of material; 1 / 2 of the primary filter liquid A is collected in the No. 1 percolation cylinder and stored in another container, the remaining 1 / 2 of the subsequent filter liquid A is introduced into the No. 2 percolation cylinder, 1 / 2 of the primary filter liquid B is collected and stored in another container, the remaining 1 / 2 of the subsequent filter liquid B is introduced into the No. 3 percolation cylinder, all the primary filter liquid C is collected, the primary filter liquid A, the primary filter liquid B and the primary filter liquid C are mixed to obtain a crude extract, and in this way, a crude extract of wild round jujube, a crude extract of wild hawthorn and a crude extract of wild wild grape are obtained respectively.

[0013] (3) Purification of solid beverage composition: The crude extract of wild jujube, wild hawthorn and wild wild grape obtained in step 1 is centrifuged at 4000r / min for 10min, the supernatant is combined, and filtered through an ultrafiltration membrane made of polymer materials such as polysulfone, polyethersulfone, polyacrylonitrile and polyvinyl chloride with a molecular weight cutoff greater than 1500Da. The filtrate is placed in a low-temperature freezer for 2h at a temperature of -50°C, and then dehydrated in a vacuum dryer at a vacuum degree of 60Pa and a drying temperature of 25 degrees for 15min to obtain dried purified wild jujube powder, purified wild hawthorn powder and purified wild wild grape powder; (4) Sterilization: The purified powder of wild jujube, wild hawthorn, and wild wild grape were sterilized by ionizing radiation for 60 minutes; (5) Mixing treatment: fully mix the sterilized wild jujube purified powder, wild hawthorn purified powder, and wild wild grape purified powder with a thickener of 1% xanthan gum; (6) Grinding the mixed powder product, and then drying it in a vacuum dryer at a vacuum degree of 60 Pa, a drying temperature of 25 degrees, and a vacuum time of 15 minutes. The dried powder product is sieved through a 70-mesh sieve to obtain a powder product of uniform coarseness and fineness; (7) Finally, the obtained powder final product is packaged to ensure the airtightness and hygiene of the solid beverage.

[0014] Preferably, in this embodiment or other embodiments, mango powder or milk powder may be added to the solid beverage or its intermediate product to improve the taste of multiple servings (the finished product such as Figure 2 as shown).

[0015] The preparation method of this embodiment was adopted, and the Folin-phenol method was used with gallic acid as the standard control to determine the total polyphenol content of wild round jujube fruit extract, wild wild grape extract, and wild hawthorn fruit extract, respectively. The polyphenol content of the wild round jujube fruit extract was determined to be 1.94 mg / g, the polyphenol content of the wild wild grape extract was measured to be 11.34 mg / g, and the polyphenol content of the wild hawthorn fruit extract was measured to be 4.21 mg / g.

[0016] The chloasma-eliminating solid beverage prepared in this embodiment can retain the effective ingredients of polyphenol compounds such as cucurbitacin and pyridoxine (vitamin B6) in the raw materials to the greatest extent.

[0017] (I) The role of vitamins in the composition: Pyridoxine (vitamin B6) is an important coenzyme component that participates in the normal metabolism of proteins, fats and sugars in the body. It can increase skin elasticity, reduce wrinkles, regulate skin metabolism and inhibit the production of melanin. If the patient has spots, he can take vitamin B6 as prescribed by the doctor, which helps to lighten pigmentation and reduce oil secretion, thereby playing a certain role in removing spots; and the round jujube is the king of vitamin C. The vitamin C in the compound extracted from it has a strong reducing effect, which can reduce the activity of tyrosinase, thereby reducing the synthesis of melanin, thereby achieving the purpose of anti-inflammatory and anti-aging effects, and at the same time can also reduce the damage of inflammation to the skin, which helps to prevent and lighten chloasma; the composition also contains vitamin E, whose side chain directly participates in the redox process of thiol, thereby inhibiting the activity of tyrosinase and reducing the formation of melanin. Vitamin E also has the effect of dilating peripheral blood vessels and improving vascular microcirculation, which helps to promote the delivery of nutrients and the excretion of metabolic waste in the body, and achieves the purpose of removing spots by whitening and lightening freckles. Compared with synthetic vitamins, natural vitamins extracted from wild grapes or wild jujubes have the advantages of good absorption, high utilization rate, safety, no toxic side effects, and longer duration in the body.

[0018] (II) Effects of polyphenol compounds in the composition: Resveratrol, proanthocyanidins, catechins, syringic acid, anthocyanidins, ferulic acid, gallic acid, grape alcohol, chlorogenic acid and other polyphenol compounds can be extracted from wild round jujube, wild wild grape and wild hawthorn. Their synergistic effect can produce the following effects on alleviating or eliminating chloasma: ① Antioxidant effect: Polyphenol compounds such as resveratrol and proanthocyanidins have antioxidant effects and can effectively remove free radicals, thereby helping to protect cells from oxidative damage and reduce oxidative stress in melanocytes, which helps to lighten the color of melasma. Catechins assist the antioxidant and other effects of vitamin C and vitamin E by increasing the survival time of vitamin E and vitamin C in the body. ② Anti-inflammatory effect: Resveratrol and proanthocyanidins can block the positive feedback loop between oxidative stress and pro-inflammatory cytokines, thereby achieving the purpose of anti-inflammatory and anti-aging effects, reducing the damage of inflammation to the skin, and thus helping to treat melasma; ③ Improve blood circulation: Resveratrol can inhibit the formation of platelets and adhesion to the blood vessel wall, inhibit the synthesis of oxygenase, thereby preventing blood clots, and can also regulate the level of cholesterol in the blood and promote metabolism. Proanthocyanidins can also reduce cholesterol and triglycerides in the blood, and maintain blood vessel patency by reducing the risk of vascular obstruction, thereby promoting facial circulation, and have a certain auxiliary effect on the improvement of chloasma; ④ Promote skin health: Resveratrol has the effects of promoting metabolism and beautifying the skin. Among them, phenolic acid compounds such as chlorogenic acid can accelerate wound healing, promote the regeneration and repair of skin cells, promote skin barrier repair, reduce pigmentation and angiogenesis, and inhibit ultraviolet-induced plasmin activity to keep the skin healthy.

[0019] ⑤ Improve overall health: Proanthocyanidins and resveratrol can increase the body's phagocytic rate and enhance antiviral ability, thereby enhancing its own disease resistance. Caffeic acid also exhibits antiviral activity and has an inhibitory effect on certain viruses, which helps prevent and treat viral infections. The improvement of immune ability can improve the overall physical condition and indirectly reduce the appearance and deterioration of melasma.

[0020] (III) The role of minerals in the composition: The composition also contains minerals such as magnesium, potassium, and calcium, which help support the health of the nervous system, assist in regulating the body to cope with stress and anxiety, improve the body's tolerance and adaptability, and reduce the formation and deterioration of melasma caused by hormone disorders; This embodiment uses liquid nitrogen grinding. The temperature of liquid nitrogen is -196°C. It can not only make various tissue components difficult to be destroyed or degraded, but also harden the tissue, increase its brittleness and make it easy to grind. The cells in liquid nitrogen are completely frozen, and grinding can achieve a good cell-breaking effect, grinding the cells into powder, releasing the substances inside for easy extraction.

[0021] The extraction method of this embodiment is scientific: the present invention adds ethanol solutions of different concentrations to wild round jujube powder, wild wild grape powder, and wild hawthorn powder for immersion, and adopts heavy percolation method for extraction. This dynamic leaching method can increase the utilization rate of ethanol solvent and the effective concentration. A concentrated solution of 1g material: 1ml crude extract can be directly obtained without concentration, thereby avoiding thermal decomposition or volatilization loss of effective ingredients.

[0022] The purification and separation effect of this embodiment is good: the separation effect is improved by using the composite separation technology of centrifugal separation + ultrafiltration membrane. Among them, the ultrafiltration membrane made of polymer materials such as polysulfone, polyethersulfone, polyacrylonitrile, polyvinyl chloride, etc. with a molecular weight cutoff greater than 1500Da is used for filtration, so that the ultrafiltration membrane can efficiently separate the target substance from the mixed solution in the concentration polarization re-separation process, improve the purity and quality of the product, and can effectively remove pollutants such as organic matter, particulate matter, bacteria, etc. in the solution, thereby improving the quality and safety of the product.

[0023] This embodiment uses 1% of the thickener xanthan gum, which can prevent the water-insoluble substances from sinking to the bottom of the water after the solid beverage is foamed, thereby improving the taste. Embodiment 2

[0024] A method for preparing a solid beverage for eliminating chloasma comprises the following steps in sequence: (1) The production process of wild jujube powder, wild wild grape powder and wild hawthorn powder is as follows: 10 parts of wild jujubes, 8 parts of wild wild grapes and 6 parts of wild hawthorns picked within three days are selected, and impurities and unqualified products are screened out; fresh wild jujubes, wild wild grapes and wild hawthorns are washed with running water to remove mud and dirt on the surface of the fruits, rinsed with distilled water twice, soaked with 75% ethanol solution for 30 seconds, and then rinsed with sterile distilled water twice, and dried with sterile filter paper; the wild jujubes, wild wild grapes and wild hawthorns are cut into thin slices, and the slices are introduced into a mortar pre-cooled with -196°C liquid nitrogen, and -196°C liquid nitrogen is poured in small amounts and multiple times. During the grinding process, the liquid nitrogen should be prevented from drying up, and the powder is quickly ground into powder, and sieved to obtain medium-specification wild jujube powder, wild wild grape powder and wild hawthorn powder, wherein the medium-specification powder is powder that can pass through the No. 4 sieve but is mixed with powder that can pass through the No. 5 sieve and does not exceed 60%; (2) Extraction of solid beverage composition: A crude extract of wild jujube, a crude extract of wild hawthorn, and a crude extract of wild grape were obtained by heavy percolation extraction, wherein a 55% ethanol solution was added to a percolation cylinder containing wild grape powder, a 55% ethanol solution was added to a percolation cylinder containing wild jujube powder, and a 35% ethanol solution was added to a percolation cylinder containing wild hawthorn powder. The specific operation is as follows; The powder raw materials are evenly placed in three percolation cylinders, each of which is arranged in series. The percolation cylinders are No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder in order. The weight ratio of the powder raw materials in No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder is 4:2:1. The amount of ethanol added to each percolation cylinder is to completely immerse the material, and the air in the percolation cylinder is exhausted. Soak for 24 hours, shake regularly, and flow out at 1 ml / min per kilogram of material; The first percolation cylinder collects 1 / 2 of the primary percolate A and stores it in another container, and the remaining 1 / 2 of the secondary percolate A is introduced into the second percolation cylinder, and 1 / 2 of the primary percolate B is collected and stored in another container, and the remaining 1 / 2 of the secondary percolate B is introduced into the third percolation cylinder, and all the primary percolate C is collected, and the primary percolate A, primary percolate B, and primary percolate C are mixed to obtain a crude extract, and in this way, a crude extract of wild round jujube, a crude extract of wild hawthorn, and a crude extract of wild wild grape are obtained respectively; (3) Purification of solid beverage composition: The crude extract of wild jujube, wild hawthorn and wild wild grape obtained in step 1 is centrifuged at 4000r / min for 10min, the supernatant is combined, and filtered through an ultrafiltration membrane made of polymer materials such as polysulfone, polyethersulfone, polyacrylonitrile and polyvinyl chloride with a molecular weight cutoff greater than 1500Da. The filtrate is placed in a low-temperature freezer for 2h at a temperature of -50°C, and then dehydrated in a vacuum dryer at a vacuum degree of 60Pa and a drying temperature of 25 degrees for 15min to obtain dried purified wild jujube powder, purified wild hawthorn powder and purified wild wild grape powder; (4) Sterilization: The purified powder of wild jujube, wild hawthorn, and wild wild grape were sterilized by ionizing radiation for 60 minutes; (5) Mixing treatment: fully mix the sterilized wild jujube purified powder, wild hawthorn purified powder, and wild wild grape purified powder with a thickener of 1% xanthan gum; (6) Grinding the mixed powder product, and then drying it in a vacuum dryer at a vacuum degree of 60 Pa, a drying temperature of 25 degrees, and a vacuum time of 15 minutes. The dried powder product is sieved through a 70-mesh sieve to obtain a powder product of uniform coarseness and fineness; (7) Finally, the obtained powder final product is packaged to ensure the airtightness and hygiene of the solid beverage.

[0025] Compared with Example 1, this embodiment adopts the preparation method of this embodiment, adopts the Folin-phenol method and uses gallic acid as a standard control to respectively determine the total polyphenol contents of wild round jujube fruit extract, wild wild grape extract, and wild hawthorn fruit extract. The polyphenol content of the wild round jujube fruit extract is determined to be 1.14 mg / g, the polyphenol content of the wild wild grape extract is determined to be 6.81 mg / g, and the polyphenol content of the wild hawthorn fruit extract is measured to be 3.74 mg / g. Example

[0026] A method for preparing a solid beverage for eliminating chloasma comprises the following steps in sequence: (1) The production process of wild jujube powder, wild wild grape powder and wild hawthorn powder is as follows: 14 parts of wild jujubes, 13 parts of wild wild grapes and 9 parts of wild hawthorns picked within three days are selected, and impurities and unqualified products are screened out; fresh wild jujubes, wild wild grapes and wild hawthorns are washed with running water to remove mud and dirt on the surface of the fruits, rinsed with distilled water twice, soaked with 75% ethanol solution for 30 seconds, and then rinsed with sterile distilled water twice, and dried with sterile filter paper; the wild jujubes, wild wild grapes and wild hawthorns are cut into thin slices, and the slices are introduced into a mortar pre-cooled with -196°C liquid nitrogen, and -196°C liquid nitrogen is poured in small amounts and multiple times. During the grinding process, the liquid nitrogen should be prevented from drying up, and the powder is quickly ground into powder, and sieved to obtain medium-specification wild jujube powder, wild wild grape powder and wild hawthorn powder, wherein the medium-specification powder is powder that can pass through the No. 4 sieve but is mixed with powder that can pass through the No. 5 sieve and does not exceed 60%; (2) Extraction of solid beverage composition: A crude extract of wild jujube, a crude extract of wild hawthorn, and a crude extract of wild grape are obtained by heavy percolation extraction, wherein a 75% ethanol solution is added to a percolation cylinder containing wild grape powder, an 80% ethanol solution is added to a percolation cylinder containing wild jujube powder, and a 60% ethanol solution is added to a percolation cylinder containing wild hawthorn powder. The specific operation is as follows; The powder raw materials are evenly placed in three percolation cylinders, each of which is arranged in series. The percolation cylinders are No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder in order. The weight ratio of the powder raw materials in No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder is 4:2:1. The amount of ethanol added to each percolation cylinder is to completely soak the material, and the air in the percolation cylinder is exhausted. Soak for 48 hours, shake regularly, and flow out at 3 ml / min per kilogram of material; The first percolation cylinder collects 1 / 2 of the primary filtrate A and stores it in another container, and the remaining 1 / 2 of the secondary filtrate A is introduced into the second percolation cylinder, and 1 / 2 of the primary filtrate B is collected and stored in another container, and the remaining 1 / 2 of the secondary filtrate B is introduced into the third percolation cylinder, and all the primary filtrate C is collected, and the primary filtrate A, primary filtrate B, and primary filtrate C are mixed to obtain a crude extract, and in this way, a crude extract of wild jujube, a crude extract of wild hawthorn, and a crude extract of wild wild grape are obtained respectively. (3) Purification of solid beverage composition: The crude extract of wild jujube, a crude extract of wild hawthorn, and a crude extract of wild wild grape obtained in step 1 are centrifuged at 4000 r / min for 10 min, and the supernatants are combined and filtered through an ultrafiltration membrane made of a polymer material such as polysulfone, polyethersulfone, polyacrylonitrile, and polyvinyl chloride with a molecular weight cutoff greater than 1500 Da. The filtrate was placed in a low-temperature freezer for 2 hours at a temperature of -50°C, and then dehydrated in a vacuum dryer at a vacuum degree of 60Pa and a drying temperature of 25 degrees for 15 minutes to obtain dried wild round jujube purified powder, wild hawthorn purified powder, and wild wild grape purified powder; (4) Sterilization: The purified powder of wild jujube, wild hawthorn, and wild wild grape were sterilized by ionizing radiation for 60 minutes; (5) Mixing treatment: fully mix the sterilized wild jujube purified powder, wild hawthorn purified powder, and wild wild grape purified powder with a thickener of 1% xanthan gum; (6) Grinding the mixed powder product, and then drying it in a vacuum dryer at a vacuum degree of 60 Pa, a drying temperature of 25 degrees, and a vacuum time of 15 minutes. The dried powder product is sieved through a 70-mesh sieve to obtain a powder product of uniform coarseness and fineness; (7) Finally, the obtained powder final product is packaged to ensure the airtightness and hygiene of the solid beverage.

[0027] Compared with Example 1, this embodiment adopts the preparation method of this embodiment, adopts the Folin-phenol method and uses gallic acid as a standard control to respectively determine the total polyphenol contents of wild jujube fruit extract, wild Vitis vinifera extract, and wild Hawthorn fruit extract. The polyphenol content of the wild jujube fruit extract is determined to be 2.78 mg / g, the polyphenol content of the wild Vitis vinifera extract is determined to be 5.84 mg / g, and the polyphenol content of the wild Hawthorn fruit extract is determined to be 2.69 mg / g.

[0028] According to the above embodiment, the following reference table is obtained: Example\Ingredients Jujube polyphenols Vitis vinifera polyphenols Hawthorn polyphenols Total polyphenols Embodiment 1 1.94mg / g 11.34mg / g 4.21mg / g 17.49mg / g Embodiment 2 1.14mg / g 6.81mg / g 3.74mg / g 11.69mg / g Embodiment 3 2.78mg / g 5.84mg / g 2.69mg / g 11.31mg / g The above three embodiments can effectively retain the components of jujube polyphenols, wild grape polyphenols, and hawthorn polyphenols. Among them, the total polyphenol content extracted in Example 1 is the highest, which is suitable for rapid treatment of chloasma; the total polyphenol content extracted in Example 2 is less, but it is suitable for long-term storage and taking; the jujube polyphenol content extracted in Example 3 is the highest, which is suitable for people with specific physiques (such as hot physique).

[0029] The following are practical application cases of the present invention: The first inventor of the present invention, Hou Bo, suffered from chloasma in 2011 (his symptoms are as follows Figure 3-Figure 4 As shown in the figure), after unsuccessful diagnosis and treatment in major hospitals, the patient began to develop a chloasma treatment formula on his own at the end of 2011. After 12 years of development, he successfully developed a solid beverage formula at the end of 2022, and began to take it on his own on January 9, 2023 (its ingredients are according to the solid beverage components in Example 1), taking 21 grams of it every day to brew cold water for drinking. After 15 days of continuous use, his chloasma symptoms began to alleviate. After 75 days of continuous use, starting from April 9, 2023, his chloasma symptoms were eliminated, and there has been no rebound for 1 year and 4 months (his facial condition after recovery is shown in the figure). Figure 5 as shown).

[0030] The above description is only a preferred embodiment of the present invention and does not constitute a formal limitation on the present invention. It should be understood that the techniques, methods and devices known to ordinary technicians in the relevant fields may not be discussed in detail. However, in appropriate cases, the techniques, methods and devices should be regarded as part of the authorization specification and should be included in the protection scope of the present invention within the scope of the features defined in the claims.

Claims

1. A solid beverage for eliminating chloasma, characterized in that: The invention comprises wild round jujube fruit extract, wild mountain grape extract and wild hawthorn fruit extract. The components of the extract include: pyridoxine, resveratrol, proanthocyanidin, catechin, syringic acid, anthocyanidin, ferulic acid, gallic acid, mountain grape alcohol and chlorogenic acid.

2. A method for preparing a solid beverage for eliminating chloasma, characterized in that: The following steps are involved: S1. The production process of wild round jujube powder, wild wild grape powder and wild hawthorn powder: wild round jujube, wild wild grape and wild hawthorn are selected within three days of picking, and the wild round jujube, wild wild grape and wild hawthorn are washed with running water to remove the mud and dirt on the surface of the fruit, rinsed with distilled water, soaked with ethanol solution, and then rinsed with sterilized distilled water, and dried with sterile filter paper, and the wild round jujube, wild wild grape and the wild hawthorn are cut into thin slices, and the slices are introduced into a mortar below room temperature, and liquid nitrogen is poured in, and the slices are ground into powder, and sieved to obtain medium-sized wild round jujube powder, wild wild grape powder and wild hawthorn powder; S2. using a heavy percolation extraction method to obtain a crude extract of wild jujube, a crude extract of wild hawthorn, and a crude extract of wild wild grape, wherein a 55% to 75% ethanol solution is added to a percolation cylinder containing wild wild grape powder, a 55% to 80% ethanol solution is added to a percolation cylinder containing wild jujube powder, and a 35% to 60% ethanol solution is added to a percolation cylinder containing wild hawthorn powder; S3. The crude extract of wild round jujube, wild hawthorn, and wild wild grape obtained in step S2 is centrifuged at a high speed, the supernatants are combined, and then filtered through an ultrafiltration membrane, the filtrate is placed in a low-temperature freezer for freezing treatment, and then dehydrated by a vacuum dryer to obtain dried round jujube purified powder, wild hawthorn purified powder, and wild wild grape purified powder; S4. The purified jujube powder, wild hawthorn powder, and wild grape powder obtained in step S3 are sterilized by ionizing radiation, the sterilized wild jujube powder, wild hawthorn powder, and wild grape powder are fully mixed with a thickener, the mixed powder product is crushed and ground, and dried by a vacuum dryer to obtain a mixed powder product, the mixed powder product is sieved through a sieve to obtain a powder final product with uniform coarseness and fineness, and finally packaged.

3. The method for preparing the chloasma-eliminating solid beverage according to claim 2, characterized in that: The raw materials of the solid beverage composition are: 10 to 14 parts of wild round jujube, 8 to 13 parts of wild wild grape, and 6 to 9 parts of wild hawthorn.

4. The method for preparing the chloasma-eliminating solid beverage according to claim 2, characterized in that: The specific operation of the percolation method in step S2 is: The powder raw materials are evenly placed in three percolation cylinders, each of which is arranged in series. The percolation cylinders are No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder in order. The weight ratio of the powder raw materials in No. 1 percolation cylinder, No. 2 percolation cylinder, and No. 3 percolation cylinder is 4:2:

1. The amount of ethanol added to each percolation cylinder is to completely soak the material, and the air in the percolation cylinder is exhausted. Soak for 24 to 48 hours, shake regularly, and flow out at 1 to 3 ml / min per kilogram of material; 1 / 2 of the primary filter liquid A is collected in the No. 1 percolation cylinder and stored in another container, the remaining 1 / 2 of the subsequent filter liquid A is introduced into the No. 2 percolation cylinder, 1 / 2 of the primary filter liquid B is collected and stored in another container, the remaining 1 / 2 of the subsequent filter liquid B is introduced into the No. 3 percolation cylinder, all the primary filter liquid C is collected, the primary filter liquid A, the primary filter liquid B and the primary filter liquid C are mixed to obtain a crude extract, and in this way, a crude extract of wild round jujube, a crude extract of wild hawthorn and a crude extract of wild wild grape are obtained respectively.

5. The method for preparing the chloasma-eliminating solid beverage according to claim 2, characterized in that: The ultrafiltration membrane is made of high molecular weight materials such as polysulfone, polyethersulfone, polyacrylonitrile, polyvinyl chloride, etc., and can intercept substances with a molecular weight greater than 1500Da.

6. The method for preparing the chloasma-eliminating solid beverage according to claim 2, characterized in that: The thickener is xanthan gum, accounting for 1% of the total mass.

Images