Optimization method of preparation process of salted eucommia ulmoides formula granules

Abstract

The invention provides an optimization method of a preparation process of salted eucommia ulmoides formula granules, which comprises the following steps: step S100, detecting eucommia ulmoides decoction pieces, and selecting the eucommia ulmoides decoction pieces according to preset conditions. And step S200, carrying out a processing test on the salted eucommia ulmoides decoction pieces, preparing the salted eucommia ulmoides decoction pieces, analyzing and recording processing data, and determining the processing technology of the salted eucommia ulmoides decoction pieces according to the processing data. And step S300, performing a preparation test of the salted eucommia ulmoides formula granules, preparing the salted eucommia ulmoides formula granules, analyzing and recording preparation data, and determining the preparation process of the salted eucommia ulmoides formula granules according to the preparation data. According to the optimization method for the preparation process of the salted eucommia ulmoides formula granules, the problem that the quality of the salted eucommia ulmoides granules does not reach the standard can be solved, and the effect of producing the salted eucommia ulmoides granules with the quality reaching the standard is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine formula granules, and in particular to an optimization method for the preparation process of salt eucommia formula granules. Background Art

[0002] Eucommia ulmoides is the dried bark of Eucommia ulmoides, a plant of the Eucommia family. It is sweet and warm in nature. It enters the liver and kidney meridians. It has the functions of nourishing the liver and kidney, strengthening the tendons and bones, and calming the fetus. Salted Eucommia ulmoides is a processed product of Eucommia ulmoides. After being roasted with salt, it can be introduced into the kidney and enhance the kidney-tonifying effect.

[0003] Chinese medicine formula granules effectively avoid the situation that Chinese patent medicines are difficult to add or subtract according to symptoms, are easy to store and carry, and make taking medicine more convenient. At present, the salt eucommia Chinese medicine formula granules mainly use the static decoction extraction method. However, during the decoction process, they are easily degraded due to the influence of the preparation process, resulting in a low transfer rate of the main active ingredients and a content deviation from the technical requirements of the standard decoction, making the quality of the produced salt eucommia granules substandard. Summary of the invention

[0004] In view of the above problems, the present invention is proposed to provide an optimization method for the preparation process of a salt Eucommia formula granule that overcomes the above problems or at least partially solves the above problems, which can solve the problem that the quality of the salt Eucommia granules does not meet the standards and achieve the effect of producing salt Eucommia granules that meet the quality standards.

[0005] Specifically, the present invention provides a method for optimizing the preparation process of salt eucommia formula granules, comprising the following steps: Testing the Eucommia ulmoides decoction pieces, and selecting the Eucommia ulmoides decoction pieces according to preset conditions; Conducting a processing test of salt Eucommia slices, preparing the salt Eucommia slices and analyzing and recording the processing data, and determining the salt processing process of the Eucommia slices according to the processing data; A preparation test of the salt Eucommia ulmoides formula granules is carried out to obtain the salt Eucommia ulmoides formula granules and analyze and record the preparation data, and the preparation process of the salt Eucommia ulmoides formula granules is determined according to the preparation data.

[0006] Optionally, the preparation test includes: Wash the Eucommia ulmoides slices, cut them into strips and dry them; Add salt water to the Eucommia ulmoides slices, stir evenly and then soak; After the Eucommia ulmoides decoction pieces fully absorb the salt water, they are fried to obtain the salt Eucommia ulmoides decoction pieces.

[0007] Optionally, the processing test of the Eucommia ulmoides slices is carried out to prepare the Eucommia ulmoides slices and analyze and record the processing data, and the processing process of the Eucommia ulmoides slices is determined according to the processing data, including: The frying time and frying temperature of the Eucommia ulmoides slices are tested, the pinoresinol diglucoside content, the chlorogenic acid content and the characteristic spectrum of the salt Eucommia ulmoides slices of each group of experiments are analyzed, and the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside is obtained according to the characteristic spectrum; The content of pinoresinol diglucoside, the content of chlorogenic acid and the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside were comprehensively analyzed to determine the processing technology of the salt Eucommia ulmoides decoction pieces.

[0008] Optionally, the processing process of the salt Eucommia slices includes: After washing the Eucommia ulmoides slices, cut them into 5 mm filaments and dry them at 60°C; Add 2% saline to the Eucommia ulmoides slices, stir evenly and then soak for 1 hour; After the Eucommia ulmoides decoction pieces fully absorb the salt water, they are fried at 170° C. for 17 minutes to obtain the salt Eucommia ulmoides decoction pieces.

[0009] Optionally, the preparation test comprises: soaking the Eucommia ulmoides decoction pieces in water and then decocting them to obtain Eucommia ulmoides filtrate; The salt Eucommia ulmoides filtrate is concentrated to obtain a clear paste; Taking the clear paste and spray drying it to obtain dry paste powder; The dry paste powder is taken and dry-pressed into granules to prepare salt eucommia formula granules.

[0010] Optionally, the preparation test of the salt eucommia formula granules is conducted to prepare the salt eucommia formula granules and analyze and record the preparation data, and the preparation process of the salt eucommia formula granules is determined according to the preparation data, including: Conduct single factor and orthogonal tests on soaking time, soaking temperature, decoction time and water addition amount, and analyze and record the test data; Analyze the test data to determine whether the soaking time, the soaking temperature, the boiling time and the amount of water added are significant influencing factors and calculate a comprehensive score; Compare the comprehensive scores, and use the process conditions corresponding to the highest comprehensive score as the optimal preparation process for the salt Eucommia formula granules; According to the optimized process conditions of the salt Eucommia ulmoides formula granules, samples of the salt Eucommia ulmoides formula granules were prepared and analyzed, and the optimization results were verified by comparing with the control samples.

[0011] Optionally, the test data include: pinoresinol diglucoside content transfer rate, paste yield, characteristic spectrum of salt Eucommia ulmoides formula granules, and pinoresinol diglucoside peak area, geniposide acid peak area, and chlorogenic acid peak area are obtained according to the characteristic spectrum; The composite score is: ; Among them, A1 is the transfer rate of pinoresinol diglucoside content, A0 is the maximum pinoresinol diglucoside content transfer rate, a is the first coefficient; B1 is the paste yield rate, B0 is the maximum paste yield rate, b is the second coefficient, f 1 is the first correction factor; C1 is the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside, C0 is the maximum ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside, c is the third coefficient, f 2 is the second correction factor; D1 is the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside, D0 is the maximum ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside, d is the fourth coefficient; f 3 is the third correction factor.

[0012] Optionally, the first coefficient is 0.2; The second coefficient is 0.2; The third coefficient is 0.2; The fourth coefficient is 0.4; When the paste output rate is between 15% and 18%, the first correction factor is 1; otherwise, the first correction factor is 0.5; When the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside is between 10 and 30, the second correction factor is 1; otherwise, the second correction factor is 0.3; When the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside is between 4 and 8, the third correction factor is 1; otherwise, the third correction factor is 0.2.

[0013] Optionally, the decoction time includes a first decoction time, a second decoction time and a third decoction time; The water addition amount includes a first water addition amount, a second water addition amount and a third water addition amount; The preparation process of the salt eucommia ulmoides formula granules comprises: The salt Eucommia slices are soaked in water for 1.5 hours and then decocted three times, the first time being decocted in water 10 times the weight of the salt Eucommia slices for 1.5 hours to obtain a first filtrate; The second time, the mixture was decocted in water 8 times the weight of the Eucommia ulmoides slices for 1 hour to obtain a second filtrate; The third time, the mixture was decocted in water 8 times the weight of the Eucommia ulmoides slices for 1 hour to obtain a third filtrate; The first filtrate, the second filtrate and the third filtrate are combined to obtain a salt eucommia ulmoides filtrate; The salt Eucommia ulmoides filtrate is concentrated to obtain a clear paste with a specific gravity of 1.01; The clear paste is spray-dried under the conditions of an inlet air temperature of 170° C., an outlet air temperature of 91° C., and a liquid inlet frequency of 11 Hz to obtain a dry paste powder; The dry paste powder is taken and dry-pressed into granules to prepare salt eucommia formula granules.

[0014] Optionally, the testing of Eucommia ulmoides decoction pieces and selecting the Eucommia ulmoides decoction pieces according to preset conditions include: Performing characteristic spectrum analysis on the Eucommia ulmoides decoction pieces to obtain the peak area of ​​geniposide, the peak area of ​​pinoresinol diglucoside and the peak area of ​​chlorogenic acid; The Eucommia ulmoides decoction pieces are selected according to the ratio of the peak area of ​​the geniposide to the peak area of ​​the pinoresinol diglucoside and the ratio of the peak area of ​​the chlorogenic acid to the peak area of ​​the pinoresinol diglucoside.

[0015] In an optimization method for the preparation process of salt eucommia formula granules of the present invention, the preparation method of salt eucommia formula granules includes the preparation of salt eucommia decoction pieces and the preparation of salt eucommia formula granules, using eucommia decoction pieces as raw materials, preparing eucommia decoction pieces into salt eucommia decoction pieces, and then extracting the salt eucommia decoction pieces, and preparing the extract into salt eucommia formula granules. During the optimization, the eucommia decoction pieces are first tested, and high-quality eucommia decoction pieces are selected according to the test data. Then, the process of preparing salt eucommia decoction pieces from eucommia decoction pieces is optimized to improve the quality of salt eucommia decoction pieces and the preparation efficiency of salt eucommia decoction pieces. Finally, the extraction process of salt eucommia decoction pieces is optimized to improve the quality of salt eucommia formula granules and the preparation efficiency of salt eucommia formula granules. The optimization method of the preparation process of salt-Eucommia formula granules includes selecting high-quality Eucommia slices, optimizing the processing technology of salt-Eucommia slices and optimizing the preparation process of salt-Eucommia formula granules. The optimization is carried out from multiple preparation steps of salt-Eucommia formula granules. The optimization of the preparation process of salt-Eucommia formula granules is more comprehensive, and the quality of salt-Eucommia formula granules is improved from multiple preparation steps to produce salt-Eucommia granules that meet quality standards.

[0016] Based on the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings, those skilled in the art will become more aware of the above and other objects, advantages and features of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Hereinafter, some specific embodiments of the present invention will be described in detail in an exemplary and non-limiting manner with reference to the accompanying drawings. The same reference numerals in the accompanying drawings indicate the same or similar components or parts. It should be understood by those skilled in the art that these drawings are not necessarily drawn to scale. In the accompanying drawings: Figure 1 is a schematic flow chart of an optimization method for the preparation process of salt Eucommia ulmoides formula granules according to one embodiment of the present invention; Figure 2 is a schematic flow chart of a processing process of Eucommia ulmoides salt slices according to an embodiment of the present invention; Figure 3 is a schematic flow chart of a preparation process of salt Eucommia ulmoides formula granules according to one embodiment of the present invention; Figure 4 is a specific schematic flow chart of an optimization method for the preparation process of salt Eucommia ulmoides formula granules according to one embodiment of the present invention; Figure 5 It is the characteristic spectrum of the reference medicinal material of the salt Eucommia ulmoides formula granules; Figure 6 This is the characteristic spectrum of the salt Eucommia formula granules in Example 4. DETAILED DESCRIPTION

[0018] Refer to the following Figures 1 to 6 To describe an optimization method for the preparation process of a salt Eucommia formula granule according to an embodiment of the present invention. In the description of this embodiment, it should be understood that the terms "first" and "second" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features, that is, include one or more of the features. In the description of the present invention, the meaning of "multiple" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined. When a feature "includes or contains" one or some of the features it covers, unless otherwise specifically described, this indicates that other features are not excluded and other features may be further included.

[0019] In the description of the present embodiment, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0020] Figure 1 is a schematic flow chart of an optimization method for the preparation process of salt Eucommia ulmoides formula granules according to an embodiment of the present invention, such as Figure 1 As shown, and refer to Figures 2 to 6 The embodiment of the present invention provides a method for optimizing the preparation process of salt Eucommia ulmoides formula granules, comprising the following steps: Step S100, testing Eucommia ulmoides slices and selecting Eucommia ulmoides slices according to preset conditions.

[0021] Step S200, conducting a processing test of the salt Eucommia slices, preparing the salt Eucommia slices and analyzing and recording the processing data, and determining the processing technology of the salt Eucommia slices according to the processing data.

[0022] Step S300, conducting a preparation test of the salt Eucommia ulmoides formula granules, preparing the salt Eucommia ulmoides formula granules and analyzing and recording the preparation data, and determining the preparation process of the salt Eucommia ulmoides formula granules according to the preparation data.

[0023] In this embodiment, the preparation method of salt eucommia formula granules includes the preparation of salt eucommia slices and the preparation of salt eucommia formula granules. Eucommia slices are used as raw materials, and the eucommia slices are prepared into salt eucommia slices, and then the salt eucommia slices are extracted, and the extract is prepared into salt eucommia formula granules. During optimization, the eucommia slices are first tested, and high-quality eucommia slices are selected according to the test data. Then, the process of preparing salt eucommia slices from eucommia slices is optimized to improve the quality of salt eucommia slices and the preparation efficiency of salt eucommia slices. Finally, the extraction process of salt eucommia slices is optimized to improve the quality of salt eucommia formula granules and the preparation efficiency of salt eucommia formula granules. The optimization method of the preparation process of salt-Eucommia formula granules includes selecting high-quality Eucommia slices, optimizing the processing technology of salt-Eucommia slices and optimizing the preparation process of salt-Eucommia formula granules. The optimization is carried out from multiple preparation steps of salt-Eucommia formula granules. The optimization of the preparation process of salt-Eucommia formula granules is more comprehensive, and the quality of salt-Eucommia formula granules is improved from multiple preparation steps to produce salt-Eucommia granules that meet quality standards.

[0024] In some embodiments of the present invention, Figure 2 As shown, the preparation test includes: Step S210, washing the Eucommia ulmoides slices, cutting them into strips and drying them.

[0025] Step S220, adding salt water to the Eucommia ulmoides slices, stirring evenly and then soaking.

[0026] Step S230, frying the Eucommia slices after they have fully absorbed the salt water to obtain salted Eucommia slices.

[0027] In this embodiment, when preparing the salt Eucommia slices, the Eucommia slices are first cut into shreds, added with salt water and stirred evenly, and then soaked until the salt water is fully absorbed, and then fried to prepare the salt Eucommia slices. The preparation method of the salt Eucommia slices is simple and easy to operate.

[0028] In some embodiments of the present invention, Figure 4 As shown, step S200, performing a processing test of salt Eucommia ulmoides slices, preparing salt Eucommia ulmoides slices and analyzing and recording processing data, and determining the processing process of salt Eucommia ulmoides slices according to the processing data, including: Step S240, testing the frying time and temperature of the Eucommia ulmoides slices, analyzing the pinoresinol diglucoside content, chlorogenic acid content and characteristic spectrum of the salt Eucommia ulmoides slices of each group of experiments, and obtaining the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside according to the characteristic spectrum.

[0029] Step S250, comprehensively analyzing the content of pinoresinol diglucoside, the content of chlorogenic acid, and the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside, and determining the processing technology of the salt Eucommia ulmoides slices.

[0030] In this embodiment, the frying process of the preparation of salt Eucommia ulmoides is optimized, the preparation test of salt Eucommia ulmoides slices is carried out with frying time and frying temperature as influencing factors, and the content of pinoresinol diglucoside and chlorogenic acid and characteristic spectrum analysis are carried out on the prepared salt Eucommia ulmoides slices. The ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside is obtained according to the characteristic spectrum. The processing test process with a larger ratio of pinoresinol diglucoside content, chlorogenic acid content and the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside is selected as the best processing process of salt Eucommia ulmoides slices. In the production of salt Eucommia formula granules, the processing technology of salt Eucommia formula granules has a great relationship with the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside in the characteristic spectrum. In order to determine the influence of factory processing technology on the characteristic spectrum, different frying temperatures and times were used to investigate the effects on the content of pinoresinol diglucoside, the content of chlorogenic acid and the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside in the characteristic spectrum, thereby providing technical support for the factory processing technology.

[0031] In some embodiments of the present invention, the frying time of Eucommia ulmoides slices is 13 min to 18 min. For example, the frying time of Eucommia ulmoides slices is 13 min, 14 min, 15 min, 16 min, 17 min or 18 min.

[0032] In some embodiments of the present invention, the frying temperature of Eucommia ulmoides slices is 150° C. to 180° C. For example, the frying time of Eucommia ulmoides slices is 150° C., 160° C., 170° C. or 180° C.

[0033] In the present embodiment, as the frying temperature increases, the color of the salt eucommia slices deepens, and the pinoresinol diglucoside content and the chlorogenic acid content are both on a downward trend, but the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside in the characteristic spectrum increases sharply when the temperature reaches above 160°C, and the ratio reaches the upper limit of the specified standard when the temperature reaches 180°C. At the same time, it was found in the process of the experiment that when the amount of salt eucommia processed is large, a stacking effect will occur, that is, after the salt eucommia slices are piled up after processing, the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside in the characteristic spectrum will increase sharply. Therefore, considering that the amount of salt eucommia slices processed in the industrial production process is large, the processing temperature should be controlled to 170°C, and they should be cooled in time to ensure that the quality of the salt eucommia slices is within the standard requirements.

[0034] In some embodiments of the present invention, the Eucommia slices were tested at a frying temperature of 270°C, and the Eucommia slices were completely carbonized, and the peak type of the characteristic spectrum was significantly different from that of the standard spectrum.

[0035] In some embodiments of the present invention, the processing process of the salt Eucommia ulmoides slices includes: Step S211, wash the Eucommia ulmoides slices, cut them into 5 mm filaments, and dry them at 60°C.

[0036] Step S221, add 2% saline to the Eucommia slices, stir evenly and let it soak for 1 hour.

[0037] Step S231, after the Eucommia ulmoides slices fully absorb the salt water, stir-fry at 170°C for 17 minutes to obtain salt Eucommia ulmoides slices.

[0038] In this embodiment, the processing process of salt Eucommia ulmoides was tested, and the results showed that when the frying time was 17 minutes and the frying temperature was 170°C, the content of pinoresinol diglucoside, the content of chlorogenic acid and the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside in the salt Eucommia ulmoides slices were large. Therefore, the processing process under this condition was selected as the optimal process.

[0039] In some embodiments of the present invention, Figure 3 As shown, the preparation test includes: Step S310, soaking the Eucommia ulmoides slices in water and then boiling them to obtain Eucommia ulmoides filtrate.

[0040] Step S320, concentrating the salt Eucommia ulmoides filtrate to obtain a clear paste.

[0041] Step S330, taking the clear paste and spray drying it to obtain dry paste powder.

[0042] Step S340, taking the dry paste powder and dry-pressing it into granules to obtain salt Eucommia ulmoides formula granules.

[0043] In the present embodiment, when preparing the salt eucommia formula granules, the salt eucommia slices are first decocted and extracted, and the salt eucommia filtrate after decoction is concentrated, dried and dry-pressed to obtain the salt eucommia formula granules. After the salt eucommia slices are soaked, water enters the tissue cells through osmosis, the salt eucommia slices become soft, and the cells swell, which is more conducive to the dissolution of the active ingredients in the salt eucommia slices. Moreover, the active ingredients in the salt eucommia slices are easier to be extracted by water in the subsequent decoction process, thereby improving the extraction rate of the active ingredients. The decoction process temperature is high, which can destroy the cell wall, so that the active ingredients wrapped in the cell wall and the cell membrane are released, so that the active ingredients in the salt eucommia slices are dissolved in water faster and more completely, thereby improving the extraction effect of the salt eucommia slices and improving the quality of the salt eucommia formula granules. The preparation method of the salt eucommia formula granules is simple, easy to operate, and convenient for the preparation of the salt eucommia formula granules.

[0044] In some embodiments of the present invention, Figure 4 As shown, step S300, a preparation test of salt eucommia formula granules is conducted to obtain salt eucommia formula granules and analyze and record the preparation data, and a preparation process of salt eucommia formula granules is determined according to the preparation data, including: Step S350, performing single factor test and orthogonal test on the soaking time, soaking temperature, boiling time and water addition amount, and analyzing and recording the test data.

[0045] Step S360, analyzing the test data to determine whether the soaking time, soaking temperature, boiling time and water addition amount are significant influencing factors and calculating a comprehensive score.

[0046] Step S370, comparing the comprehensive scores, and taking the process conditions corresponding to the highest comprehensive score as the optimal preparation process for the salt Eucommia formula granules.

[0047] Step S380, preparing and analyzing the salt Eucommia formula granules sample according to the optimized process conditions of the salt Eucommia formula granules, and verifying the optimization result by comparing with the control sample.

[0048] In this embodiment, the soaking time, soaking temperature, decoction time and water addition are pre-tested to select the appropriate value range of each influencing factor. According to the selected value range, a four-factor three-level orthogonal test is set. The clear paste and salt eucommia formula granules in the test are tested and analyzed, and the comprehensive score is calculated according to the obtained test results, and the preparation process with a higher comprehensive score is selected as the optimal preparation process of the salt eucommia formula granules. The salt eucommia formula granules are prepared using the optimal preparation process and compared with the salt eucommia formula granule control sample to verify the optimization result. The soaking time, soaking temperature, decoction time and water addition of the salt eucommia decoction pieces are optimized to study the optimal preparation method of the salt eucommia formula granules, thereby improving the quality of the salt eucommia formula granules. In addition, optimizing the preparation method of the salt eucommia formula granules can save preparation time, reduce energy consumption, and thereby improve the preparation efficiency of the salt eucommia formula granules.

[0049] In some embodiments of the present invention, the test data include: pinoresinol diglucoside content transfer rate, paste yield, characteristic spectrum of salt Eucommia ulmoides formula granules, and the pinoresinol diglucoside peak area, geniposide acid peak area, and chlorogenic acid peak area are obtained according to the characteristic spectrum.

[0050] The salt eucommia formula granules stipulate the content range of pinoresinol diglucoside, and also stipulate the ratio of the peak area of ​​geniposide acid to the peak area of ​​pinoresinol diglucoside, and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside. The ratio of the peak area of ​​geniposide acid to the peak area of ​​pinoresinol diglucoside, and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside are related to the quality control of medicinal materials and the preparation process. Therefore, the quality of medicinal materials is controlled, and the pinoresinol diglucoside content transfer rate, paste yield, and characteristic spectrum peak ratio are used as comprehensive evaluation indicators to screen out the best preparation process for the salt eucommia formula granules. This ensures that the salt eucommia formula granules meet national quality standards during production.

[0051] In some embodiments of the present invention, an orthogonal test for the preparation of salt Eucommia formula granules is carried out on the basis of the selection of Eucommia decoction pieces and the processing technology of salt Eucommia. After the orthogonal test, the influences on the preparation process of salt Eucommia formula granules from large to small are decoction time, soaking time, soaking temperature, and water addition. Decoction time is a significant influencing factor, which can significantly reduce the ratio of the chlorogenic acid peak area to the pinoresinol diglucoside peak area. Within the test range, the amount of water added has the least effect, and the amount of water added mainly affects the size of the paste yield.

[0052] In some embodiments of the present invention, the comprehensive score is: ; Among them, A1 is the transfer rate of pinoresinol diglucoside content, A0 is the maximum pinoresinol diglucoside content transfer rate, a is the first coefficient; B1 is the paste yield rate, B0 is the maximum paste yield rate,b is the second coefficient, f 1 is the first correction factor. C1 is the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside, C0 is the maximum ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside, c is the third coefficient, f 2 is the second correction factor. D1 is the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside, D0 is the maximum ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside, d is the fourth coefficient, f 3 is the third correction factor.

[0053] In some embodiments of the present invention, the first coefficient is 0.2, the second coefficient is 0.2, the third coefficient is 0.2, and the fourth coefficient is 0.4.

[0054] In some embodiments of the present invention, when the cream yield is between 15% and 18%, the first correction factor is 1. Otherwise, the first correction factor is 0.5. When the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside is between 10 and 30, the second correction factor is 1. Otherwise, the second correction factor is 0.3. When the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside is between 4 and 8, the third correction factor is 1, otherwise, the third correction factor is 0.2.

[0055] In this embodiment, the comprehensive score is corrected according to the values ​​of the cream yield, the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside, and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside. When comparing the qualities of the salt eucommia formula granules under various experimental conditions, the comprehensive score can accurately compare the salt eucommia formula granules under different experimental conditions, thereby making the optimization of the preparation process of the salt eucommia formula granules more accurate, providing a basis for controlling the quality of the salt eucommia formula granules.

[0056] In some embodiments of the present invention, the calculation method of the transfer rate of pinoresinol diglucoside content is:

[0057] Wherein, A1 is the pinoresinol diglucoside content transfer rate. m1 is the pinoresinol diglucoside content in the salt eucommia extract. M1 is the weight of the salt eucommia extract. m0 is the pinoresinol diglucoside content in the salt eucommia slices. M0 is the weight of the salt eucommia slices.

[0058] In some embodiments of the present invention, when determining the content and characteristic spectrum of pinoresinol diglucoside, take salt Eucommia ulmoides formula granules or Eucommia ulmoides slices, grind them and take 0.6g, and put them into a conical flask. Add 50mL of 70% methanol, weigh the weight, heat to reflux for 30min, weigh the weight again after cooling, make up the lost weight with 70% methanol, shake well, filter, take the subsequent filtrate, and obtain the sample to be tested. Take the samples to be tested and inject them into the liquid chromatograph respectively, and measure the content and characteristic spectrum of pinoresinol diglucoside. According to the characteristic spectrum, the peak area of ​​pinoresinol diglucoside, the peak area of ​​geniposide acid and the peak area of ​​chlorogenic acid are obtained.

[0059] In some embodiments of the present invention, the calculation method of the paste yield is:

[0060] Wherein, B1 is the paste yield, M1 is the weight of the salt eucommia extract, N is the dryness ratio of the salt eucommia extract, and M0 is the weight of the salt eucommia slices.

[0061] Among them, the dryness rate of the salt Eucommia ulmoides extract is determined according to the drying method in the moisture determination method in the "Chinese Pharmacopoeia".

[0062] In some embodiments of the present invention, the decoction time includes a first decoction time, a second decoction time and a third decoction time. In some embodiments of the present invention, the amount of water added includes a first amount of water added, a second amount of water added and a third amount of water added.

[0063] In this embodiment, after three decoctions to extract the salt eucommia filtrate, when extracting the active ingredients in the salt eucommia, the concentration difference of the active ingredients inside and outside the cells of the salt eucommia slices is used to diffuse the active ingredients in the cells into the water. As the active ingredients in the water increase, the diffusion rate of the active ingredients decreases. By replacing new water, the diffusion rate of the active ingredients increases, the diffusion rate of the active ingredients is improved, thereby reducing the extraction time of the active ingredients, and then improving the quality of the salt eucommia formula granules.

[0064] In other embodiments of the present invention, when performing decoction extraction, decoction extraction can be performed once, twice, or four times, so that the active ingredients in the salt Eucommia slices can be fully extracted.

[0065] In some embodiments of the present invention, the first decoction time is 0.5h to 1.5h. For example, the first decoction time is 0.5h, 1h or 1.5h.

[0066] The second decoction time is 0.5h to 1h. For example, the second decoction time is 0.5h, 0.6h, 0.7h, 0.8h, 0.9h or 1h.

[0067] The third decoction time is 0.5h to 1h. For example, the third decoction time is 0.5h, 0.6h, 0.7h, 0.8h, 0.9h or 1h.

[0068] In some embodiments of the present invention, the first amount of water added is 8 to 12 times the weight of the salt Eucommia slices. For example, the first amount of water added is 8, 9, 10, 11 or 12 times the weight of the salt Eucommia slices.

[0069] The second amount of water added is 6 to 10 times the weight of the salt Eucommia slices. For example, the second amount of water added is 6, 7, 8, 9 or 10 times the weight of the salt Eucommia slices.

[0070] The third amount of water added is 6 to 10 times the weight of the salt Eucommia slices. For example, the third amount of water added is 6, 7, 8, 9 or 10 times the weight of the salt Eucommia slices.

[0071] In this embodiment, after optimization of the salt Eucommia formula granules, the amount of water added has little effect on the salt Eucommia formula granules. Therefore, under the premise of meeting the quality of the salt Eucommia formula granules, the amount of water added is reduced to save the preparation cost of the salt Eucommia formula granules.

[0072] In some embodiments of the present invention, the soaking time is 0.5 h to 1.5 h. For example, the soaking time is 0.5 h, 1 h or 1.5 h.

[0073] In this embodiment, the salt Eucommia slices are fully soaked in water, and the active ingredients in the medicinal materials are more easily extracted by water during the decoction process. In addition, reasonable soaking can reduce the loss of some ingredients caused by high temperature during the decoction process.

[0074] In some embodiments of the present invention, the soaking temperature is 0° C. to 60° C. For example, the soaking temperature is 0° C., 20° C., 40° C. or 60° C.

[0075] In this embodiment, the amount of dextrin used in the preparation process of the salt Eucommia ulmoides formula granules does not exceed 6% of the weight of the salt Eucommia ulmoides decoction pieces.

[0076] In some embodiments of the present invention, in step S320, the salt Eucommia ulmoides filtrate is concentrated to obtain a clear paste, and the concentration temperature is 50° C. to 85° C. For example, the concentration temperature is 50° C., 60° C., 70° C., 80° C., 85° C. The relative density of the clear paste is 1.01 to 1.03.

[0077] In this embodiment, the clear paste is prepared by decompression concentration, and the salt Eucommia ulmoides filtrate is concentrated in a vacuum environment. No high temperature is required during concentration to prevent the high temperature from affecting the salt Eucommia ulmoides filtrate. The relative density of the clear paste is the ratio of the density of the clear paste to the density of water at 60°C to 70°C. The relative density of the clear paste affects the effect of the spray. If the relative density of the clear paste is too large, it will cause spraying difficulties, thereby affecting the drying of the clear paste.

[0078] Furthermore, when the salt Eucommia ulmoides filtrate is concentrated, the steam pressure does not exceed 0.10 MPa, and the vacuum degree is -0.03 MPa to -0.09 MPa.

[0079] In some embodiments of the present invention, in step S330, the clear paste is spray-dried to obtain a dry paste powder, the air inlet temperature is 140°C to 180°C, for example, the air inlet temperature is 140°C, 150°C, 160°C, 170°C or 180°C. The air outlet temperature is 80°C to 110°C, for example, the air outlet temperature is 80°C, 90°C, 100°C or 110°C. The liquid inlet frequency is 10Hz to 25Hz, for example, the liquid inlet frequency is 10Hz, 13Hz, 15Hz, 18Hz, 20Hz, 23Hz or 25Hz.

[0080] In this embodiment, a spray dryer is used to dry the dry paste powder, so that the clear paste is dried instantly, the drying time of the clear paste is reduced, and the production cost of the salt eucommia formula granules is reduced. In addition, most of the heat in the spray drying process is used to evaporate the water in the clear paste, and the heating time of the clear paste is extremely short, and the quality of the dry paste powder will not be affected by the high temperature.

[0081] In some embodiments of the present invention, in step S340, the dry paste powder is taken and dry-pressed to obtain the salt Eucommia formula granules. The dry pressing granulation method is adopted, the dry paste powder is added into the hopper of the dry pressing granulator, and the dry paste powder is fed into the pressing wheel through the feeding and dry-pressed into tablets, and then the sieve mesh number of the crushing and granulation is 12 mesh.

[0082] The conveying rotation speed is 20 r / min to 200 r / min, for example, the conveying rotation speed is 20 r / min, 50 r / min, 100 r / min, 150 r / min or 200 r / min.

[0083] The pressing wheel speed is 3 r / min to 30 r / min, for example, the pressing wheel speed is 3 r / min, 5 r / min, 10 r / min, 15 r / min, 20 r / min, 25 r / min or 30 r / min.

[0084] The granulation speed is 20 r / min to 200 r / min. For example, the granulation speed is 20 r / min, 50 r / min, 100 r / min, 150 r / min or 200 r / min.

[0085] In some embodiments of the present invention, the preparation process of the formula granules of Eucommia ulmoides salt comprises: Step S311, soaking the salt Eucommia slices in water at room temperature for 1.5 hours and then decocting them three times, the first time decocting them in water 10 times the weight of the salt Eucommia slices for 1.5 hours to obtain the first filtrate, wherein the room temperature is 0°C to 30°C.

[0086] Step S312, decocting the Eucommia ulmoides slices in water 8 times the weight of the Eucommia ulmoides slices for a second time for 1 hour to obtain a second filtrate.

[0087] Step S313, decocting the Eucommia ulmoides slices in water 8 times the weight of the Eucommia ulmoides slices for a third time for 1 hour to obtain a third filtrate.

[0088] Step S314, combining the first filtrate, the second filtrate and the third filtrate to obtain the salt eucommia ulmoides filtrate.

[0089] Step S321, concentrating the salt Eucommia ulmoides filtrate to obtain a clear paste with a specific gravity of 1.01.

[0090] Step S331, taking the clear paste and spray drying it under the conditions of an inlet air temperature of 170°C, an outlet air temperature of 91°C, and a liquid inlet frequency of 11 Hz to obtain a dry paste powder.

[0091] Step S341, taking the dry paste powder and dry-pressing it into granules to obtain salt Eucommia ulmoides formula granules.

[0092] In some embodiments of the present invention, Figure 4 As shown, step S100, testing Eucommia ulmoides decoction pieces, and selecting Eucommia ulmoides decoction pieces according to preset conditions, including: Step S110, performing characteristic spectrum analysis on the Eucommia ulmoides decoction pieces to obtain the peak area of ​​geniposide, the peak area of ​​pinoresinol diglucoside and the peak area of ​​chlorogenic acid.

[0093] Step S120, selecting Eucommia ulmoides decoction pieces according to the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside.

[0094] In this embodiment, when selecting Eucommia ulmoides decoction pieces, characteristic spectrum analysis is performed on the Eucommia ulmoides decoction pieces, and Eucommia ulmoides decoction pieces with appropriate ratios of geniposide peak area to pinoresinol diglucoside peak area and chlorogenic acid peak area to pinoresinol diglucoside peak area are selected as raw materials for salt Eucommia ulmoides formula granules. The quality of the salt Eucommia ulmoides formula granules is controlled by controlling the quality of the Eucommia ulmoides decoction pieces to ensure that the national quality standards are met during the production of the salt Eucommia ulmoides formula granules.

[0095] In some embodiments of the present invention, the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside of the thicker Eucommia pieces are low. According to the national drug standard for salt Eucommia, the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside should be 5.7 to 46.7, and the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside should be 2.4 to 10.0. In combination with the test results, when selecting Eucommia pieces, select Eucommia pieces with a ratio of geniposide to the peak area of ​​pinoresinol diglucoside of 8 to 25 and a ratio of chlorogenic acid to the peak area of ​​pinoresinol diglucoside of 3 to 10, so as to produce salt Eucommia formula granules that meet the national drug standards. Example

[0096] Step S11, washing the Eucommia ulmoides slices, cutting them into 5 mm filaments, and drying them at 60° C.; Step S12, adding 2% saline to the Eucommia ulmoides slices, stirring evenly and then soaking for 1 hour; Step S13, after the Eucommia ulmoides slices fully absorb the salt water, stir-fry at 170° C. for 17 minutes to obtain the salt Eucommia ulmoides slices.

[0097] Step S14, performing content detection and characteristic spectrum analysis on the salt Eucommia ulmoides slices.

[0098] The experiment measured that the surface of the broken silk of the salt Eucommia ulmoides slices after frying was dark brown, the content of pinoresinol diglucoside was 2.51 mg / g, the content of chlorogenic acid was 2.45 mg / g, and the ratio of the peak area of ​​the first characteristic peak in the characteristic spectrum to the peak area of ​​pinoresinol diglucoside was 5.6. Example

[0099] Step S21, soaking the salt Eucommia slices in water at room temperature for 1 hour and then decocting them, decocting them in water 8 times the weight of the salt Eucommia slices for 1.5 hours for the first time to obtain a first filtrate.

[0100] Step S22, decocting the Eucommia ulmoides slices in water 6 times the weight of the Eucommia ulmoides slices for a second time for 1 hour to obtain a second filtrate.

[0101] Step S23, decocting the Eucommia ulmoides slices in water 6 times the weight of the Eucommia ulmoides slices for a third time for 1 hour to obtain a third filtrate.

[0102] Step S24, combining the first filtrate, the second filtrate and the third filtrate to obtain the salt eucommia ulmoides filtrate.

[0103] Step S25, concentrating the salt Eucommia ulmoides filtrate to obtain a clear paste with a specific gravity of 1.01.

[0104] Step S26, taking the clear paste and spray drying it under the conditions of an inlet air temperature of 170° C., an outlet air temperature of 91° C., and a liquid inlet frequency of 11 Hz to obtain a dry paste powder.

[0105] Step S27, taking the dry paste powder and dry-pressing it into granules to obtain salt Eucommia ulmoides formula granules.

[0106] According to the quality standards of salt Eucommia ulmoides formula granules, the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside is 5.7 to 46.7, and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside is 2.4 to 10.0.

[0107] The prepared salt Eucommia formula granules were tested, and the transfer rate of pinoresinol diglucoside content in the salt Eucommia formula granules was 73.6%, the paste yield was 13.1%, the ratio of the peak area of ​​geniposide acid to the peak area of ​​pinoresinol diglucoside in the characteristic spectrum was 13.8, the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside was 5.7, and the comprehensive evaluation was 61.4. According to the measured data, the salt Eucommia formula granules meet the requirements of the national drug standards. Example

[0108] Step S31, soaking the Eucommia ulmoides slices in water at room temperature for 1.5 hours and then decocting them three times, the first time decocting them in water 10 times the weight of the Eucommia ulmoides slices for 1.5 hours to obtain a first filtrate.

[0109] Step S32, decocting the Eucommia ulmoides slices in water 8 times the weight of the Eucommia ulmoides slices for a second time for 1 hour to obtain a second filtrate.

[0110] Step S33, decocting the Eucommia ulmoides slices in water 8 times the weight of the Eucommia ulmoides slices for a third time for 1 hour to obtain a third filtrate.

[0111] The subsequent steps are the same as in Example 2.

[0112] The prepared salt Eucommia formula granules were tested, and the transfer rate of pinoresinol diglucoside content in the salt Eucommia formula granules was 89.7%, the paste yield was 16.7%, the ratio of the peak area of ​​geniposide acid to the peak area of ​​pinoresinol diglucoside in the characteristic spectrum was 15.6, the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside was 5.3, and the comprehensive evaluation was 75.5. According to the measured data, the salt Eucommia formula granules meet the requirements of the national drug standards. Example

[0113] Step S41, soak 30 kg of salt Eucommia slices in water at room temperature for 1.5 hours and then decoct them three times, the first time decocting them in water 10 times the weight of the salt Eucommia slices for 1.5 hours to obtain a first filtrate.

[0114] Step S42, decocting the Eucommia ulmoides slices in water 8 times the weight of the Eucommia ulmoides slices for a second time for 1 hour to obtain a second filtrate.

[0115] Step S43, decocting the Eucommia ulmoides slices in water 8 times the weight of the Eucommia ulmoides slices for a third time for 1 hour to obtain a third filtrate.

[0116] The subsequent steps are the same as in Example 2.

[0117] According to the national drug standards for salt Eucommia ulmoides, the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside should be 0.6 to 15.7, the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside should be 5.7 to 46.7, and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside should be 2.4 to 10.0.

[0118] Figure 5 This is the characteristic spectrum of the reference medicinal materials for the salt Eucommia ulmoides formula granules. Figure 6 is the characteristic spectrum of the salt Eucommia formula granules in this embodiment. Among them, M1, M2 and M3 are the characteristic spectrum results of the detection of multiple batches of salt Eucommia formula granules prepared under the same conditions. Peak 1 is the first characteristic peak, peak 2 is the geniposide peak, peak 3 is the chlorogenic acid peak, and peak 5 is the pinoresinol diglucoside peak. Figure 5 and Figure 6 It can be seen that there is basically no peak at peak 1 in the characteristic spectrum of the Eucommia ulmoides control medicinal material, while there is an obvious peak at peak 1 in the characteristic spectrum of the salt Eucommia ulmoides formula granules prepared according to the selected process.

[0119] The prepared salt Eucommia formula granules were tested, and the water content of the prepared salt Eucommia formula granules was 4%, and each 1g of salt Eucommia formula granules contained 11.6mg of pinoresinol diglucoside, and the extract was 56.4%. In thin layer identification, the salt Eucommia formula granules and the control medicinal materials showed the same color at the corresponding positions. The pinoresinol diglucoside content transfer rate was 91.3%, and the paste yield rate was 17.5%. The ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside was 5.7, the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside was 12.9, and the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside was 6.7. The ratios are all in the middle of the standard range, indicating that the optimized preparation process of salt Eucommia formula granules can continuously and stably produce salt Eucommia formula granules that meet national drug standards, and are suitable for large-scale production.

[0120] At this point, those skilled in the art should recognize that, although multiple exemplary embodiments of the present invention have been shown and described in detail herein, many other variations or modifications that conform to the principles of the present invention can still be directly determined or derived based on the content disclosed in the present invention without departing from the spirit and scope of the present invention. Therefore, the scope of the present invention should be understood and recognized as covering all these other variations or modifications.

Claims

1. A method for optimizing the preparation process of salt Eucommia ulmoides granules, It is characterized in that The following steps are involved: Testing the Eucommia ulmoides decoction pieces, and selecting the Eucommia ulmoides decoction pieces according to preset conditions; Conducting a processing test of the Eucommia ulmoides salt slices, preparing the Eucommia ulmoides salt slices and analyzing and recording the processing data, and determining the processing process of the Eucommia ulmoides salt slices according to the processing data; A preparation test of the salt Eucommia formula granules is carried out to obtain the salt Eucommia formula granules and analyze and record the preparation data, and the preparation process of the salt Eucommia formula granules is determined according to the preparation data.

2. The optimization method according to claim 1, It is characterized in that The preparation test includes: Wash the Eucommia ulmoides slices, cut them into strips and dry them; Add salt water to the Eucommia ulmoides slices, stir evenly and then soak; After the Eucommia ulmoides decoction pieces fully absorb the salt water, they are fried to obtain the salt Eucommia ulmoides decoction pieces.

3. The optimization method according to claim 2, It is characterized in that The method of conducting a processing test of the Eucommia ulmoides decoction pieces, preparing the Eucommia ulmoides decoction pieces and analyzing and recording the processing data, and determining the processing process of the Eucommia ulmoides decoction pieces according to the processing data, comprises: The frying time and frying temperature of the Eucommia ulmoides slices are tested, the pinoresinol diglucoside content, the chlorogenic acid content and the characteristic spectrum of the salt Eucommia ulmoides slices of each group of experiments are analyzed, and the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside is obtained according to the characteristic spectrum; The content of pinoresinol diglucoside, the content of chlorogenic acid and the ratio of the peak area of ​​the first characteristic peak to the peak area of ​​pinoresinol diglucoside were comprehensively analyzed to determine the processing technology of the salt Eucommia ulmoides decoction pieces.

4. The optimization method according to claim 3, It is characterized in that The processing technology of the salt eucommia slices includes: After washing the Eucommia ulmoides slices, cut them into 5 mm filaments and dry them at 60°C; Add 2% saline to the Eucommia ulmoides slices, stir evenly and then soak for 1 hour; After the Eucommia ulmoides decoction pieces fully absorb the salt water, they are fried at 170° C. for 17 minutes to obtain the salt Eucommia ulmoides decoction pieces.

5. The optimization method according to claim 1, It is characterized in that The preparation test includes: soaking the Eucommia ulmoides decoction pieces in water and then decocting them to obtain Eucommia ulmoides filtrate; The salt Eucommia ulmoides filtrate is concentrated to obtain a clear paste; Taking the clear paste and spray drying it to obtain dry paste powder; The dry paste powder is taken and dry-pressed into granules to prepare salt eucommia formula granules.

6. The optimization method according to claim 5, It is characterized in that The preparation test of the salt eucommia formula granules is carried out to obtain the salt eucommia formula granules and analyze and record the preparation data, and the preparation process of the salt eucommia formula granules is determined according to the preparation data, including: Conduct single factor and orthogonal tests on soaking time, soaking temperature, decoction time and water addition amount, and analyze and record the test data; Analyze the test data to determine whether the soaking time, the soaking temperature, the boiling time and the amount of water added are significant influencing factors and calculate a comprehensive score; Compare the comprehensive scores, and use the process conditions corresponding to the highest comprehensive score as the optimal preparation process for the salt Eucommia formula granules; According to the optimized process conditions of the salt Eucommia ulmoides formula granules, samples of the salt Eucommia ulmoides formula granules were prepared and analyzed, and the optimization results were verified by comparing with the control samples.

7. The optimization method according to claim 6, It is characterized in that The test data include: pinoresinol diglucoside content transfer rate, paste yield rate, characteristic spectrum of salt Eucommia ulmoides formula granules, and pinoresinol diglucoside peak area, geniposide acid peak area, and chlorogenic acid peak area are obtained according to the characteristic spectrum; The composite score is: ; Among them, A 1 is the content transfer rate of pinoresinol diglucoside, A 0 is the maximum pinoresinol diglucoside content transfer rate, a is the first coefficient; B 1 is the paste yield, B 0 is the maximum paste yield, b is the second coefficient, f 1 is the first correction factor; C 1 is the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside, C 0 is the maximum ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside, c is the third coefficient, f 2 is the second correction factor; D 1 is the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside, D 0 is the maximum ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside, d is the fourth coefficient; f 3 is the third correction factor.

8. The optimization method according to claim 7, It is characterized in that The first coefficient is 0.2; The second coefficient is 0.2; The third coefficient is 0.2; The fourth coefficient is 0.4; When the paste output rate is between 15% and 18%, the first correction factor is 1; otherwise, the first correction factor is 0.5; When the ratio of the peak area of ​​geniposide to the peak area of ​​pinoresinol diglucoside is between 10 and 30, the second correction factor is 1; otherwise, the second correction factor is 0.3; When the ratio of the peak area of ​​chlorogenic acid to the peak area of ​​pinoresinol diglucoside is between 4 and 8, the third correction factor is 1; otherwise, the third correction factor is 0.

2.

9. The optimization method according to claim 8, It is characterized in that The decoction time includes a first decoction time, a second decoction time and a third decoction time; The water addition amount includes a first water addition amount, a second water addition amount and a third water addition amount; The preparation process of the salt eucommia ulmoides formula granules comprises: The salt Eucommia slices are soaked in water for 1.5 hours and then decocted three times, the first time being decocted in water 10 times the weight of the salt Eucommia slices for 1.5 hours to obtain a first filtrate; The second time, the mixture was decocted in water 8 times the weight of the Eucommia ulmoides slices for 1 hour to obtain a second filtrate; The third time, the mixture was decocted in water 8 times the weight of the Eucommia ulmoides slices for 1 hour to obtain a third filtrate; The first filtrate, the second filtrate and the third filtrate are combined to obtain a salt eucommia ulmoides filtrate; The salt Eucommia ulmoides filtrate is concentrated to obtain a clear paste with a specific gravity of 1.01; The clear paste is spray-dried under the conditions of an inlet air temperature of 170° C., an outlet air temperature of 91° C., and a liquid inlet frequency of 11 Hz to obtain a dry paste powder; The dry paste powder is taken and dry-pressed into granules to prepare salt eucommia formula granules.

10. The optimization method according to claim 1, It is characterized in that The testing of the Eucommia pieces and selecting the Eucommia pieces according to preset conditions include: Performing characteristic spectrum analysis on the Eucommia ulmoides decoction pieces to obtain the peak area of ​​geniposide, the peak area of ​​pinoresinol diglucoside and the peak area of ​​chlorogenic acid; The Eucommia ulmoides decoction pieces are selected according to the ratio of the peak area of ​​the geniposide to the peak area of ​​the pinoresinol diglucoside and the ratio of the peak area of ​​the chlorogenic acid to the peak area of ​​the pinoresinol diglucoside.

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