Traditional Chinese medicine compound preparation for treating androgenetic alopecia and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound preparation for treating androgenetic alopecia and a preparation method thereof. The traditional Chinese medicine compound preparation is prepared from the following raw material medicines: radix salviae miltiorrhizae, radix astragali, semen coicis, radix sophorae flavescentis, bran-fried rhizoma atractylodis, radix angelicae sinensis, liquorice root, salted cortex phellodendri, radix achyranthis bidentatae and rhizoma chuanxiong. The preparation method comprises the following steps: mixing the raw material medicines, soaking in water, decocting with big fire until boiling, continuously decocting with soft fire, and filtering to obtain liquid medicine and medicine residues; continuously decocting the decoction dregs with the big fire until boiling, then continuously decocting with the small fire, and filtering again to obtain secondary liquid medicine; and combining the liquid medicines obtained in two times, concentrating, and refrigerating for later use. Pharmacodynamic tests show that the traditional Chinese medicine compound preparation has a good treatment effect on androgenetic alopecia, and has good market popularization value and potential.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine preparations, in particular to a Chinese medicine compound preparation for treating androgenic alopecia and a preparation method thereof. Background Art

[0002] Androgenetic Alopecia (AGA) is the most common type of hair loss in clinical practice. Male androgenic alopecia usually begins around puberty, with progressive receding hairline, thinning and thinning of the hair on the top of the head, and in severe cases, baldness. Symptoms include scalp seborrheic dermatitis, itching, increased scaling, and folliculitis, which can have a significant negative impact on the patient's personal image, mental health, and quality of life.

[0003] Male androgenic alopecia has the characteristics of genetic correlation, androgen dependence and multi-pathway regulation. At present, the clinical treatment of androgenic alopecia mainly includes drugs, local scalp injections, laser and hair transplantation. Although there are certain effects, the treatment of androgenic alopecia has the characteristics of drug side effects and high recurrence rate after discontinuation of medication. Oral finasteride and topical minoxidil are the current first-line treatments for male androgenic alopecia, and their efficacy is reliable. Finasteride is a type II 5α-reductase inhibitor that can inhibit the conversion of testosterone to dihydrotestosterone and play an anti-androgenic role. Due to its potential side effects such as erectile dysfunction, some patients cannot accept long-term medication. The mechanism of action of minoxidil in the treatment of AGA may be related to its vasodilation and improvement of local blood perfusion of the scalp. Its main adverse reactions include scalp itching, scaling and hirsutism. In addition, scalp injection of platelet-rich plasma, scalp injection of botulinum toxin, low-energy laser and other therapies have also achieved certain efficacy, but their high price limits their promotion and application in clinical practice.

[0004] Therefore, androgenic alopecia has become a research hotspot for disfiguring skin diseases, and it is urgent to explore safe and effective therapeutic drugs and methods. Summary of the invention

[0005] The present invention aims to provide a Chinese medicinal compound preparation for treating androgenic alopecia and a preparation method thereof.

[0006] Specifically, this application provides the following technical solutions:

[0007] A traditional Chinese medicine compound preparation for treating androgenic alopecia, wherein the raw materials are composed of salvia miltiorrhiza, astragalus, coix seed, sophora flavescens, stir-fried atractylodes, angelica, liquorice, phellodendron chinense, achyranthes bidentata and ligusticum chuanxiong.

[0008] Furthermore, the added amount of each component of the raw material medicine is 5 parts of Salvia miltiorrhiza, 6 parts of Astragalus, 4 parts of Coix seeds, 3 parts of Sophora flavescens, 3 parts of Atractylodes macrocephala, 2 parts of Angelica sinensis, 2 parts of Licorice, 3 parts of Phellodendron chinense, 3 parts of Achyranthes bidentata, and 2 parts of Ligusticum chuanxiong.

[0009] The present invention also provides a preparation method of a Chinese medicinal compound preparation for treating androgenic alopecia, which specifically comprises the following steps: mixing raw materials, soaking in water for 20 to 40 minutes, decocting over high heat until boiling, then changing to low heat, and continuing to decoct over low heat for 40 to 60 minutes, filtering to obtain a medicinal liquid and medicinal residues; continuing to decoct the medicinal residues over high heat until boiling, then changing to low heat, and continuing to decoct over low heat for 20 to 40 minutes, filtering again to obtain a secondary medicinal liquid; and combining the medicinal liquids obtained twice and concentrating them.

[0010] Among them, the concentration of the concentrated crude drug is 1.65g / mL.

[0011] In addition to concentrated decoction dosage forms, the raw materials can also be processed, pre-treated and extracted, and then auxiliary materials can be added to make oral liquids, granules, tablets, capsules or honey pills.

[0012] The preparation method of the oral solution is as follows: boil the raw material in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract to a relative density of 1.05±0.02, remove impurities and purify it by high-speed centrifugation, cool and stand for 24 hours, take the supernatant, filter it with pulp cake, concentrate it to a relative density of 1.15-1.20, package it, sterilize it, and then get the oral solution.

[0013] The preparation method of the capsule is as follows: boil the raw material in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add ethanol to granulate, dry, and put it into capsules to obtain capsules.

[0014] The preparation method of the granules is as follows: boil the raw material in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol (volume fraction), heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract to a relative density of 1.05±0.02, remove impurities and purify it by high-speed centrifugation, cool and stand for 24 hours, take the supernatant, filter the pulp cake, concentrate it to a relative density of 1.15-1.20, spray dry, dry granulate, and package it with aluminum-plastic composite film to obtain the granules.

[0015] The tablet preparation method is as follows: boil the raw material in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add starch, granulate it, and press it into tablets.

[0016] The preparation method of honey pills is as follows: boil the raw material medicine in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat reflux extraction 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate it under reduced pressure, vacuum dry the extract, crush it into fine powder, add refined honey, stir the honey and medicine powder in a mass ratio of 1.5:1, and prepare honey pills.

[0017] Compared with the prior art, the Chinese medicinal compound preparation for treating androgenic alopecia and the preparation method thereof of the present invention have at least the following beneficial effects:

[0018] The Chinese medicine compound preparation of the present invention is composed of salvia miltiorrhiza, astragalus, coix seed, sophora flavescens, bran-fried atractylodes, angelica, liquorice, salt phellodendron, cyathula and ligusticum chuanxiong. In the prescription, sophora flavescens clears away heat and dries dampness, coix seed is lightly infiltrating and relieving dampness, and atractylodes lancea dries dampness and removes numbness. The three medicines can remove dampness and are the main medicine; salvia miltiorrhiza cools blood and promotes blood circulation, astragalus invigorates qi and replenishes deficiency, angelica invigorates blood and promotes blood circulation, the four medicines promote qi and promote blood circulation, and ligusticum chuanxiong regulates qi and promotes blood circulation, nourishes hair pores, and promotes hair growth, which are the ministerial medicines; salt phellodendron nourishes yin and reduces fire, and cyathula invigorates liver and kidney, guides medicine to guide dampness downward, which are the adjuvant medicines; liquorice harmonizes various medicines and is the guiding medicine. The whole prescription is compatible, clears away heat and dampness, invigorates qi and promotes blood circulation, and inhibits fat growth, so it is good at treating androgenic alopecia with internal dampness and heat.

[0019] The research found that the Chinese medicine compound preparation for treating androgenic alopecia of the present invention has significant clinical and animal experimental effects in treating androgenic alopecia models. The Chinese medicine compound preparation of the present invention improves androgenic alopecia by clearing away heat and dampness, invigorating qi and activating blood circulation, inhibiting fat growth, improving scalp seborrheic dermatitis, and regulating androgen metabolism.

[0020] The Chinese medicinal compound preparation for treating androgenic alopecia and its preparation method of the present invention will be further described below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 These are clinical photos of the experimental group before and after treatment.

[0022] Figure 2 These are trichoscope photos of the experimental group before and after treatment (upper left and upper right are before treatment, lower left and lower right are after treatment), showing that hair density and scalp erythema improved after treatment. DETAILED DESCRIPTION

[0023] Example 1 Decoction Preparation

[0024] Take 15g of Salvia miltiorrhiza, 18g of Astragalus, 12g of Coix seed, 9g of Sophora flavescens, 9g of Atractylodes lancea with bran, 6g of Angelica sinensis, 6g of Licorice, 9g of Phellodendron chinense, 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong, mix them, soak them in water for 20-40 minutes, boil them over high heat, then switch to low heat, continue boiling over low heat for 40-60 minutes, filter to obtain a medicinal liquid and a medicinal residue; continue to boil the medicinal residue over high heat until boiling, then switch to low heat, continue boiling over low heat for 20-40 minutes, filter again to obtain a secondary medicinal liquid; combine the two obtained medicinal liquids and concentrate them, and the crude drug concentration after concentration is 1.65g / mL.

[0025] Example 2 Oral Liquid Preparation

[0026] Take 15g of Salvia miltiorrhiza, 18g of Astragalus, 12g of Coix seed, 9g of Sophora flavescens, 9g of Atractylodes macrocephala, 6g of Angelica sinensis, 6g of Licorice, 9g of Phellodendron chinense, 9g of Achyranthes bidentata, and 6g of Chuanxiong, boil them in boiling water for 10min, take them out, simmer them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1h, combine the filtrate, recover the ethanol under reduced pressure, and after reduced pressure concentration, vacuum dry the extract (conditions: temperature is 70℃, pressure is 0.08MPa) to a relative density of 1.05±0.02 (temperature is 60℃), high-speed centrifuge to remove impurities and purify, cool and stand for 24h, take the supernatant, filter the pulp cake, concentrate it to a relative density of 1.15-1.20 (temperature is 60℃), package it, and sterilize it.

[0027] Example 3 Capsule Preparation

[0028] Take 15g of Salvia miltiorrhiza, 18g of Astragalus, 12g of Coix seed, 9g of Sophora flavescens, 9g of Atractylodes lancea, 6g of Angelica sinensis, 6g of Licorice, 9g of Phellodendron chinense, 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong, boil them in boiling water for 10min, take them out, simmer them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1h, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature is 60℃, pressure is 0.08MPa), grind it into fine powder, add ethanol to granulate, dry it, and put it into capsules to obtain the product.

[0029] Example 4 Granule Preparation

[0030] Take 15g of Salvia miltiorrhiza, 18g of Astragalus, 12g of Coix seed, 9g of Sophora flavescens, 9g of Atractylodes lancea with bran, 6g of Angelica sinensis, 6g of Licorice, 9g of Phellodendron chinense, 9g of Achyranthes bidentata, and 6g of Chuanxiong, boil them in boiling water for 10min, take them out, simmer them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1h, combine the filtrate, recover the ethanol under reduced pressure, and after reduced pressure concentration, vacuum dry the extract (temperature is 70℃, pressure is 0.08MPa) to a relative density of 1.05±0.02 (temperature is 60℃), high-speed centrifuge to remove impurities and purify, cool and stand for 24h, take the supernatant, filter the pulp cake, concentrate it to a relative density of 1.15-1.20 (temperature is 60℃), spray dry, dry granulate, and package it with aluminum-plastic composite film.

[0031] Example 5 Tablet Preparation

[0032] Take 15g of Salvia miltiorrhiza, 18g of Astragalus, 12g of Coix seed, 9g of Sophora flavescens, 9g of Atractylodes lancea with bran, 6g of Angelica sinensis, 6g of Licorice, 9g of Phellodendron chinense, 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong, boil them in boiling water for 10min, take them out, simmer them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1h, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, dry the extract in vacuum (temperature is 60℃, pressure is 0.08MPa), grind it into fine powder, add starch, granulate it, and press it into tablets.

[0033] Example 6 Honey Pill Preparation

[0034] Take 15g of Danshen, 18g of Astragalus, 12g of Coix Seed, 9g of Sophora flavescens, 9g of Atractylodes lancea, 6g of Angelica sinensis, 6g of Licorice, 9g of Phellodendron chinense, 9g of Achyranthes bidentata, and 6g of Chuanxiong, boil them in boiling water for 10min, take them out, simmer thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1h. Combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature is 60℃, pressure is 0.08MPa), crush into fine powder, add refined honey, stir the honey and the powder in a ratio of 1.5:1, and prepare honey pills.

[0035] In order to verify the activity of the above Chinese herbal compound preparation, the Chinese herbal compound composition in water decoction form prepared in Example 1 was used to act on male patients with androgenic alopecia.

[0036] The diagnostic criteria for male androgenic alopecia refer to the "2023 Chinese Clinical Practice Guidelines: Diagnosis and Treatment of Androgenic Alopecia" (Chinese Medical Association Plastic Surgery Branch Chinese Androgenic Alopecia Diagnosis and Treatment Guidelines Development Working Group, Plastic Surgery National Medical Quality Control Center, Chinese Plastic Surgery Association Hair Medicine Branch, etc. 2023 Chinese Clinical Practice Guidelines: Diagnosis and Treatment of Androgenic Alopecia [J]. Chinese Journal of Plastic Surgery, 2024, 40(1): 1-20.). The clinical manifestations are the receding hairline of the forehead and / or the progressive thinning of the hair on the top of the head, which eventually exposes the scalp, usually accompanied by symptoms of increased scalp oil secretion. Dermoscopy shows that the hair diameter variation rate in the hair loss area is >20%.

[0037] Case selection: (1) Inclusion criteria: male, aged 20-45 years; diagnosed with AGA; Hamilton-Norwood classification meets vertex level III, IV, and V; TCM syndrome meets damp-heat syndrome: scalp seborrheic, erythema, itching, increased scaling, and folliculitis meet at least two items, and have systemic manifestations such as sticky stools, poor appetite, abdominal distension, and limb heaviness; can adhere to medication and follow-up and sign informed consent; no AGA-related treatment within 3 months. (2) Exclusion criteria: combined with other hair diseases; allergic to the trial drugs (minoxidil, finasteride, dehumidification treatment, control) and their components; patients with liver and kidney dysfunction, malignant tumors, and mental disorders; those who have participated in other clinical studies in the past 3 months; any other conditions that the researchers believe are not suitable for participating in the trial. Liver and kidney dysfunction. (3) Dropout criteria: poor compliance, such as failure to take medication regularly or fail to return for follow-up visits for more than 2 weeks; use of other AGA therapies during the intervention period; severe adverse reactions during the intervention period; subjects requesting to withdraw; and subjects deemed unsuitable to continue participating in the study by the investigator.

[0038] Intervention plan: (1) Control group: 1 mg of finasteride tablets (specification: 1 mg; produced by Merk Sharp & Dohme Limited; batch number: National Medicine Standard No. J20150142), taken orally once a day; minoxidil tincture (specification: 5%; produced by Zhejiang Wansheng Pharmaceutical Co., Ltd.; batch number: National Medicine Standard No. H20010714), applied to the hair loss area twice a day. The treatment period is 6 months. (2) Experimental group: 30 mL of the drug in Example 1, taken orally twice a day; the specifications and usage of finasteride tablets and minoxidil tincture are the same as those of the control group. The treatment period is 6 months.

[0039] Baseline conditions: 64 patients who met the above criteria were recruited and randomly divided into the control group and the treatment group by block randomization table and opening envelopes, with 32 cases in each group. The age of the patients in the control group ranged from 23 to 45 years old, with an average age of 33.19±6.06 years old, and the course of androgenic alopecia ranged from 2 to 22 years, with an average course of 8.75±6.47 years. There were 11 cases of Norwood–Hamilton grade III vertex, 10 cases of grade IV, and 11 cases of grade V. The age of the patients in the experimental group ranged from 25 to 45 years old, with an average age of 33.84±5.14 years old, and the course of androgenic alopecia ranged from 2 to 13 years, with an average course of 6.19±3.04 years. There were 11 cases of Norwood–Hamilton grade III vertex, 11 cases of grade IV, and 10 cases of grade V. The baseline conditions of the two groups were comparable. 30 patients in the control group and the experimental group completed the study, with a dropout rate of 6.25%, all of whom were Norwood–Hamilton grade III vertex patients.

[0040] Evaluation plan: Compare the clinical scores of the bald area (thinning hair, seborrheic dermatitis, dandruff and itching), trichoscope indicators (hair number, diameter, and proportion of growing hair), endocrine indicators (uric acid, sex hormone-binding globulin, free testosterone index), and safety indicators (alanine aminotransferase, aspartate aminotransferase, and blood creatinine) before and after treatment.

[0041] The results of the study are as follows:

[0042] (1) Clinical score of baldness area. Figure 1 The clinical photos of the experimental group before and after treatment. After treatment, the total clinical score of the bald area in the control group was significantly improved, the scores of sparse hair and scalp seborrheic dermatitis were significantly reduced, and the scores of itching and dandruff were increased. The scores and significance are shown in Table 1. After treatment, the total clinical score of the bald area in the experimental group was significantly improved, and the scores of each single item were reduced: the scores of sparse hair and seborrheic dermatitis were significantly reduced, and the scores of itching and dandruff were reduced. The scores and significance are shown in Table 2. Before treatment, there was no statistical difference in the clinical scores and total scores of the bald area between the control group and the experimental group (P>0.05), and they were comparable. After treatment, the total score of clinical manifestations in the bald area of ​​the experimental group was significantly better than that of the control group (P=0.005, Z=-2.792), and there was no significant difference in the remaining scores between the two groups.

[0043] Table 1 Comparison of clinical manifestation scores of baldness area in the control group before and after treatment (points, )

[0044]

[0045]

[0046] Table 2 Comparison of clinical manifestation scores of baldness area in the experimental group before and after treatment (points, )

[0047]

[0048] (2) Dermoscopic indicators. Figure 2 The following are the trichoscope photos of the experimental group before and after treatment. It can be seen that the hair density and scalp erythema were improved after treatment. After treatment, the hair diameter of the control group increased significantly, the number of hair increased, and the proportion of hair in the growth period was not significantly different from before. The hair diameter of the experimental group increased significantly, the number of hair increased, and the proportion of hair in the growth period increased significantly from before. The above situation is shown in Table 3 and Table 4. There was no statistical difference in the dermoscopic indicators between the control group and the experimental group before treatment (P>0.05), and they were comparable. After treatment, the hair diameter, hair number, and proportion of hair in the growth period of the experimental group were better than those of the control group, but there was no statistical difference (P>0.05).

[0049] Table 3 Comparison of dermoscopic indicators before and after treatment in the control group

[0050]

[0051] Table 4 Comparison of dermoscopic indicators before and after treatment in the experimental group

[0052]

[0053] (3) Hair appearance indexes. According to the evaluation of the researchers, after treatment, 3 patients in the control group had no significant improvement, 2 patients in the experimental group had no significant improvement, and the remaining patients had different degrees of improvement, as shown in Table 5.

[0054] Table 5 Comparison of hair appearance after treatment (example)

[0055]

[0056] (4) Endocrine indicators. After treatment, uric acid levels in both the control and experimental groups decreased compared with before treatment, with significant differences in the experimental group. After treatment, sex hormone binding globulin decreased in the control group, while free testosterone index increased, with no statistical difference. After treatment, sex hormone binding globulin levels in the experimental group increased significantly, while free testosterone index decreased. The above conditions are shown in Tables 6 and 7.

[0057] Table 6 Comparison of endocrine indicators before and after treatment in the control group

[0058]

[0059]

[0060] Table 6 Comparison of androgen indexes in the experimental group before and after treatment

[0061]

[0062] (5) Safety indicators. No serious adverse reactions were reported in either group during treatment. One patient in the control group complained of nausea after taking finasteride (3.13%), and two patients complained of scalp itching after applying minoxidil tincture (6.25%). One patient in the experimental group complained of abnormal ejaculation after taking finasteride (3.13%), and one patient complained of scalp itching after applying minoxidil tincture (3.13%). The liver and kidney function levels of both groups were within the normal range before and after treatment, and there was no significant difference (P>0.05).

[0063] (6) Early clinical observations show that the Chinese herbal compound preparation prepared by the present invention has significant efficacy in treating androgenic alopecia, has good safety, improves seborrheic dermatitis in patients, reduces blood uric acid levels, and improves androgen metabolism.

[0064] The embodiments described above are merely descriptions of preferred implementation modes of the present invention and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A Chinese medicinal compound preparation for treating androgenic alopecia, characterized in that: The raw materials are composed of salvia miltiorrhiza, astragalus, coix seed, sophora flavescens, stir-fried atractylodes, angelica sinensis, licorice, salt-cured phellodendron, Achyranthes bidentata, and ligusticum chuanxiong.

2. The Chinese medicinal compound preparation for treating androgenic alopecia according to claim 1, characterized in that: The added amount of each component of the raw material medicine is 5 parts of salvia miltiorrhiza, 6 parts of astragalus, 4 parts of coix seed, 3 parts of sophora flavescens, 3 parts of stir-fried atractylodes, 2 parts of angelica, 2 parts of liquorice, 3 parts of salt phellodendron, 3 parts of Achyranthes bidentata, and 2 parts of Chuanxiong.

3. The method for preparing the Chinese medicinal compound preparation for treating androgenic alopecia according to claim 1 or 2, characterized in that: After mixing the raw materials, soak them in water for 20 to 40 minutes, boil over high heat, then switch to low heat, and continue to boil over low heat for 40 to 60 minutes, and filter to obtain the medicinal liquid and medicinal residue; continue to boil the medicinal residue over high heat until it boils, then switch to low heat, and continue to boil over low heat for 20 to 40 minutes, and filter again to obtain the secondary medicinal liquid; the two obtained medicinal liquids are combined and concentrated.

4. The method for preparing the Chinese medicinal compound preparation for treating androgenic alopecia according to claim 3, wherein: The concentration of the concentrated crude drug was 1.65 g / mL.

5. The method for preparing the Chinese medicinal compound preparation for treating androgenic alopecia according to claim 1 or 2, characterized in that: Boil the raw material in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrate, recover the ethanol under reduced pressure, and concentrate the extract under reduced pressure and vacuum dry to a relative density of 1.05±0.02, remove impurities and purify it by high-speed centrifugation, cool and stand for 24 hours, take the supernatant, filter it with pulp cake, concentrate it to a relative density of 1.15-1.20, package it, and sterilize it to obtain the oral solution.

6. The method for preparing the Chinese medicinal compound preparation for treating androgenic alopecia according to claim 1 or 2, characterized in that: Boil the raw material drug in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, grind it into fine powder, add ethanol to granulate, dry, and put it into capsules to obtain capsules.

7. The method for preparing the Chinese medicinal compound preparation for treating androgenic alopecia according to claim 1 or 2, characterized in that: Boil the raw material in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, and concentrate the extract under reduced pressure and vacuum dry to a relative density of 1.05±0.02, remove impurities and purify it by high-speed centrifugation, cool and stand for 24 hours, take the supernatant, filter it with pulp cake, concentrate it to a relative density of 1.15-1.20, spray dry, dry granulate, and package it with aluminum-plastic composite film to obtain granules.

8. The method for preparing the Chinese medicinal compound preparation for treating androgenic alopecia according to claim 1 or 2, characterized in that: Boil the raw material drug in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add starch, granulate, and press into tablets to obtain tablets.

9. The method for preparing the Chinese medicinal compound preparation for treating androgenic alopecia according to claim 1 or 2, characterized in that: Boil the raw material medicine in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate it under reduced pressure, vacuum dry the extract, crush it into fine powder, add refined honey, stir the honey and powder in a mass ratio of 1.5:1, and prepare honey pills.

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