External cold compress liquid for improving ankylosing spondylitis and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to external cold compress liquid for improving ankylosing spondylitis and a preparation method thereof.The external cold compress liquid for improving the ankylosing spondylitis is prepared from 7.23 parts of morinda officinalis, 12.05 parts of ligusticum wallichii, 7.23 parts of radix achyranthis bidentatae, 12.05 parts of angelica sinensis, 12.05 parts of radix angelicae pubescentis, 9.64 parts of galangal, 12.05 parts of cynanchum paniculatum, 9.64 parts of polygonum cuspidatum and 18.07 parts of mistletoe; the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can achieve the effects of dispelling wind and eliminating dampness, warming channels and expelling cold, and strengthening tendons and smoothing governor meridians, has better treatment and relief effects on morning stiffness, night pain, limited activity and lumbocrural pain caused by ankylosing spondylitis, can achieve the effects of locally dispelling cold and eliminating dampness and dispersing yang qi by introducing traditional Chinese medicine ions by adopting an application method, and can achieve the effect of treating the ankylosing spondylitis by matching with sports medical treatment and rehabilitation training. The four limbs are enabled to move, muscles are healthy, tendons and vessels are good, bones are strong, joints are good, qi and blood are circulated, and ossification and fibrosis of tendon ligaments can be prevented or relieved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external cold compress liquid for improving ankylosing spondylitis and a preparation method thereof. Background Art

[0002] Ankylosing spondylitis is a chronic, progressive, inflammatory rheumatic disease that primarily affects the spine and sacroiliac joints, causing stiffness and pain in the spine, and gradually developing spinal ankylosing and deformity, which seriously affects the patient's quality of life. The specific pathogenesis of the disease has not yet been fully elucidated, but genetic, environmental, and immune factors are believed to be important causes of its onset.

[0003] Currently, the treatment of ankylosing spondylitis mainly relies on drugs to control inflammation, physical therapy to relieve pain, and surgery to correct deformities. However, these methods focus on relieving symptoms and are difficult to achieve a cure. In particular, there is a lack of efficient, convenient and low-side effect treatments for the persistent pain and discomfort that patients suffer on a daily basis. Summary of the invention

[0004] In order to overcome the above technical problems, the present invention provides an external cold compress liquid for improving ankylosing spondylitis and a preparation method thereof.

[0005] The present invention adopts the following technical solutions:

[0006] A cold compress for external use for improving ankylosing spondylitis, comprising: 5-10 parts of Morinda officinalis, 8-14 parts of Ligusticum chuanxiong, 5-10 parts of Achyranthes bidentata, 10-18 parts of Angelica sinensis, 8-14 parts of Angelica dahurica, 5-15 parts of Alpinia officinalis, 8-18 parts of Cynanchum wilfordii, 8-12 parts of Polygonum cuspidatum, and 15-20 parts of Mistletoe.

[0007] Preferably, 7.23 parts of Morinda officinalis, 12.05 parts of Ligusticum chuanxiong, 7.23 parts of Achyranthes bidentata, 12.05 parts of Angelica sinensis, 12.05 parts of Angelica dahurica, 9.64 parts of Alpinia officinalis, 12.05 parts of Cynanchum wilfordii, 9.64 parts of Polygonum cuspidatum, and 18.07 parts of Viscum album.

[0008] A method for preparing an external cold compress solution for improving ankylosing spondylitis comprises the following steps:

[0009] S1. Weigh the following pieces according to the formula ratio: 7.23 parts of Morinda officinalis, 12.05 parts of Chuanxiong, 7.23 parts of Achyranthes bidentata, 12.05 parts of Angelica sinensis, 12.05 parts of Angelica dahurica, 9.64 parts of Alpinia officinalis, 12.05 parts of Cynanchum wilfordii, 9.64 parts of Polygonum cuspidatum, and 18.07 parts of Viscum album;

[0010] S2. The above-mentioned pieces were dried, crushed, sieved through a 100-mesh sieve, put into a cotton bag, immersed in a 65% pure grain wine jar, tightly sealed, and unsealed after soaking for 180 days;

[0011] S3. Take the soaking liquid from the wine soaking tank, use an automatic filling machine to put it into medical bottles and store it at room temperature for later use.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] The medicine of the present invention is designed according to the pathogenesis of chronic inflammatory diseases of patients with ankylosing spondylitis, and can dispel wind and dampness, warm the meridians and dispel cold, strengthen the tendons and unblock the Governor Vessel, and has a good therapeutic and alleviating effect on morning stiffness, night pain, limited activity, and waist and leg pain caused by ankylosing spondylitis. The Chinese medicine ions are introduced by a patching method to achieve the effects of local dispelling cold and dampness and distributing yang energy. Combined with physical medicine and rehabilitation training, the limbs can be moved, the muscles can be strengthened, the tendons and veins can be improved, the bones can be strengthened, the joints can be benefited, the qi and blood can be circulated, and the ossification and fibrosis of the tendons and ligaments can be prevented or alleviated. DETAILED DESCRIPTION

[0014] The embodiments of the present invention are described in detail below. Unless otherwise specified, the raw materials and equipment used can be purchased from the market or are commonly used in the art. The methods in the embodiments are conventional methods in the art unless otherwise specified. The embodiments are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0015] A cold compress for external use for improving ankylosing spondylitis, comprising: 7.23 parts of Morinda officinalis, 12.05 parts of Ligusticum chuanxiong, 7.23 parts of Achyranthes bidentata, 12.05 parts of Angelica sinensis, 12.05 parts of Angelica dahurica, 9.64 parts of Alpinia officinalis, 12.05 parts of Cynanchum wilfordii, 9.64 parts of Polygonum cuspidatum, and 18.07 parts of Viscum album.

[0016] The drug toxicity and safety test of the cold compress solution is based on the "Technical Specifications for Safety of Cosmetics" (2015 edition). After multiple inspections, the items tested for the cold compress solution products all meet the requirements of the enterprise standard Q / DQKZ001-2024) "Fugu Shujin Tongluo External Compress Health Care Solution". The content of heavy metals such as lead, arsenic, mercury, and cadmium are all lower than the standard requirements, and the total number of molds, yeasts, heat-resistant Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa are all lower than the standard requirements or not detected.

[0017] Because osthole (7-methoxy-8-isopentenylcoumarin) in the drug invention is relatively exclusive, stable, and has the highest content, the content of osthole (7-methoxy-8-isopentenylcoumarin) is used as the determination standard and high pressure liquid chromatography is used for determination. The Thermo C18 column (250mm×4.6mm, 5μm) is used, the mobile phase is an acetic acid aqueous solution with a methanol volume fraction of 3% (volume ratio of 70:30), the flow rate is 1.0mL / min, and the detection wavelength is 307nm. This content determination method is sensitive, accurate, and reproducible, and can be used for quality control of angelica dahurica.

[0018] A method for preparing an external cold compress solution for improving ankylosing spondylitis comprises the following steps:

[0019] S1. Weigh the following pieces according to the formula ratio: 7.23 parts of Morinda officinalis, 12.05 parts of Chuanxiong, 7.23 parts of Achyranthes bidentata, 12.05 parts of Angelica sinensis, 12.05 parts of Angelica dahurica, 9.64 parts of Alpinia officinalis, 12.05 parts of Cynanchum wilfordii, 9.64 parts of Polygonum cuspidatum, and 18.07 parts of Viscum album;

[0020] S2. The above-mentioned pieces were dried, crushed, sieved through a 100-mesh sieve, put into a cotton bag, immersed in a 65% pure grain wine jar, tightly sealed, and unsealed after soaking for 180 days;

[0021] S3. Take the soaking liquid from the wine soaking tank, use an automatic filling machine to put it into medical bottles and store it at room temperature for later use.

[0022] How to use: Apply according to the painful area or Du channel acupoints, one patch per area, add 2.5 to 3 ml of cold compress solution to each patch, once a day, 5 to 6 hours each time. Continuous application for 30 days is a course of treatment, and generally 3 courses or more are required.

[0023] From 2018 to 2024, 58 patients were observed, including 37 males and 21 females, aged 45 to 78 years old, with a disease course of 2 to more than 10 years. 18 cases were clinically relieved, 29 cases were significantly effective, 9 cases were effective, and 2 cases were ineffective, with an overall effective rate of 97%.

[0024] Patient Zhang, 65 years old, had been ill for 5 years. After 6 courses of application, the pain in the patient's lumbar sacroiliac, cervical spine, and legs was significantly relieved, the pain in the knee joints, toe joints, and finger joints was weakened, and the morning stiffness time was shortened from 1 hour to 10 minutes, which was significantly improved compared with before treatment. The swelling and pain in the peripheral joints disappeared. He can basically take care of himself and has traveled frequently in recent years.

[0025] The patient, Mr. Liu, aged 77, had been ill for 3 years. After 4 courses of treatment, the pain in his finger joints and ankle joints basically disappeared, the stiffness and pain in the lumbar and sacral areas and the pain in the hip joints were significantly alleviated, the limited mobility was significantly improved, and he was gradually able to take care of himself from being bedridden.

[0026] The patient, Mr. Li, was 78 years old and had been ill for 7 years. After 8 courses of treatment, the pain in his wrist and knee joints was significantly relieved, his range of motion was increased, his main symptoms and signs improved, and his rheumatic immune biochemical indicators (erythrocyte sedimentation rate, C-reactive protein, antistreptolysin, etc.) returned to normal.

[0027] The patient, Mr. Cai, aged 62, suffered a knee injury in a car accident and had been suffering from the disease for more than 10 years. After 5 courses of treatment, the CT scan showed that the fluid in the knee joint cavity was absorbed, the pain was suddenly relieved, and he could go up and down the stairs freely.

[0028] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the above embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A cold compress solution for external use for improving ankylosing spondylitis, characterized in that: The components include: 5-10 parts of Morinda officinalis, 8-14 parts of Chuanxiong, 5-10 parts of Achyranthes bidentata, 10-18 parts of Angelica sinensis, 8-14 parts of Angelica dahurica, 5-15 parts of Alpinia officinalis, 8-18 parts of Cynanchum wilfordii, 8-12 parts of Polygonum cuspidatum and 15-20 parts of Viscum album.

2. The cold compress solution for external use for improving ankylosing spondylitis according to claim 1, characterized in that: include: There are 7.23 parts of Morinda officinalis, 12.05 parts of Ligusticum chuanxiong, 7.23 parts of Achyranthes bidentata, 12.05 parts of Angelica sinensis, 12.05 parts of Angelica dahurica, 9.64 parts of Alpinia officinalis, 12.05 parts of Cynanchum wilfordii, 9.64 parts of Polygonum cuspidatum, and 18.07 parts of Viscum album.

3. A method for preparing a cold compress solution for external use for improving ankylosing spondylitis, characterized in that: The following steps are involved: S1. Weigh the following pieces according to the formula ratio: 7.23 parts of Morinda officinalis, 12.05 parts of Chuanxiong, 7.23 parts of Achyranthes bidentata, 12.05 parts of Angelica sinensis, 12.05 parts of Angelica dahurica, 9.64 parts of Alpinia officinalis, 12.05 parts of Cynanchum wilfordii, 9.64 parts of Polygonum cuspidatum, and 18.07 parts of Viscum album; S2. The above-mentioned pieces were dried, crushed, sieved through a 100-mesh sieve, put into a cotton bag, immersed in a 65% pure grain wine jar, tightly sealed, and unsealed after soaking for 180 days; S3. Take the soaking liquid from the wine soaking tank, use an automatic filling machine to put it into medical bottles and store it at room temperature for later use.